ALS2CR11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.97477786
2binding of sperm to zona pellucida (GO:0007339)9.82940512
3cell-cell recognition (GO:0009988)9.61846226
4epithelial cilium movement (GO:0003351)9.44023624
5motile cilium assembly (GO:0044458)9.08739458
6spermatid development (GO:0007286)8.91145033
7reproduction (GO:0000003)8.88601387
8regulation of cilium movement (GO:0003352)8.63333213
9male meiosis (GO:0007140)8.56268503
10cilium movement (GO:0003341)8.16260293
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.03235361
12synaptonemal complex organization (GO:0070193)8.00798197
13synaptonemal complex assembly (GO:0007130)7.79304830
14single fertilization (GO:0007338)7.33144332
15sperm capacitation (GO:0048240)6.44514360
16DNA methylation involved in gamete generation (GO:0043046)6.38116111
17fertilization (GO:0009566)6.30350561
18spermatogenesis (GO:0007283)5.92943091
19male gamete generation (GO:0048232)5.90899743
20ventricular system development (GO:0021591)5.87850548
21male meiosis I (GO:0007141)5.78007635
22negative regulation of inclusion body assembly (GO:0090084)5.77484131
23regulation of acrosome reaction (GO:0060046)5.68237133
24chromosome organization involved in meiosis (GO:0070192)5.52222546
25gamete generation (GO:0007276)5.43685024
26organic cation transport (GO:0015695)5.42034385
27microtubule depolymerization (GO:0007019)5.32210459
28germ cell development (GO:0007281)5.23158171
29meiotic nuclear division (GO:0007126)5.20272411
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.17953784
31regulation of microtubule-based movement (GO:0060632)5.11526813
32microtubule severing (GO:0051013)5.02852690
33seminiferous tubule development (GO:0072520)4.91232437
34regulation of inclusion body assembly (GO:0090083)4.76010093
35meiosis I (GO:0007127)4.66625495
36cell recognition (GO:0008037)4.60606173
37calcium ion-dependent exocytosis (GO:0017156)4.48937823
38meiotic cell cycle (GO:0051321)4.42113606
39protein localization to cilium (GO:0061512)4.38852663
40sister chromatid cohesion (GO:0007062)4.37462633
41multicellular organismal reproductive process (GO:0048609)4.27854690
42positive regulation of meiosis (GO:0045836)4.27432328
43protein polyglutamylation (GO:0018095)4.11082451
44establishment of protein localization to Golgi (GO:0072600)4.07340367
45genitalia morphogenesis (GO:0035112)4.06222341
46retinal cone cell development (GO:0046549)4.06150805
47response to pheromone (GO:0019236)4.02128539
48positive regulation of meiotic cell cycle (GO:0051446)4.01525387
49monoubiquitinated protein deubiquitination (GO:0035520)3.95237230
50left/right pattern formation (GO:0060972)3.94902364
51protein targeting to Golgi (GO:0000042)3.94339092
52gene silencing by RNA (GO:0031047)3.86416688
53chromosome condensation (GO:0030261)3.80763712
54spermatid nucleus differentiation (GO:0007289)3.79026965
55retrograde transport, vesicle recycling within Golgi (GO:0000301)3.67395296
56nuclear pore complex assembly (GO:0051292)3.64971305
57DNA packaging (GO:0006323)3.64381576
58negative regulation of cytosolic calcium ion concentration (GO:0051481)3.62692193
59chaperone-mediated protein complex assembly (GO:0051131)3.60686133
60female gamete generation (GO:0007292)3.54509563
61glycerol ether metabolic process (GO:0006662)3.53335494
62multicellular organismal development (GO:0007275)3.49430660
63regulation of DNA endoreduplication (GO:0032875)3.48030294
64regulation of female gonad development (GO:2000194)3.40488544
65synapsis (GO:0007129)3.40252154
66meiotic cell cycle process (GO:1903046)3.36767027
67intraciliary transport (GO:0042073)3.36324848
68regulation of response to osmotic stress (GO:0047484)3.27872476
69gonadal mesoderm development (GO:0007506)3.27197348
70ether metabolic process (GO:0018904)3.25422953
71mitotic metaphase plate congression (GO:0007080)3.21581298
72negative regulation of organelle assembly (GO:1902116)3.15992437
73microtubule-based movement (GO:0007018)3.11515044
74regulation of meiosis I (GO:0060631)3.11082499
75axoneme assembly (GO:0035082)3.08449523
76DNA double-strand break processing (GO:0000729)3.05898162
77oogenesis (GO:0048477)3.05693988
78regulation of meiosis (GO:0040020)3.03768169
79regulation of spindle checkpoint (GO:0090231)3.02919585
80cilium organization (GO:0044782)2.98648762
81regulation of centriole replication (GO:0046599)2.98003174
82amino-acid betaine transport (GO:0015838)2.96507233
83carnitine transport (GO:0015879)2.96507233
84nucleus organization (GO:0006997)2.96247154
85nuclear pore organization (GO:0006999)2.93282899
86mitotic sister chromatid cohesion (GO:0007064)2.93225084
87nucleoside diphosphate phosphorylation (GO:0006165)2.91883416
88carnitine transmembrane transport (GO:1902603)2.91590684
89glycolytic process (GO:0006096)2.90782833
90protein K11-linked deubiquitination (GO:0035871)2.90347575
91lactate metabolic process (GO:0006089)2.88342967
92phosphatidylethanolamine biosynthetic process (GO:0006646)2.87340508
93metaphase plate congression (GO:0051310)2.86234331
94alditol metabolic process (GO:0019400)2.85599722
95cilium assembly (GO:0042384)2.84766932
96gene silencing (GO:0016458)2.83773571
97pore complex assembly (GO:0046931)2.80693864
98peristalsis (GO:0030432)2.80426000
99polyol catabolic process (GO:0046174)2.80057129
100cellular component assembly involved in morphogenesis (GO:0010927)2.79804586
101regulation of meiotic cell cycle (GO:0051445)2.79212419
102positive regulation of mitotic sister chromatid separation (GO:1901970)2.79121662
103positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.79121662
104positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.79121662
105single strand break repair (GO:0000012)2.78767824
106left/right axis specification (GO:0070986)2.78416198
107phagocytosis, recognition (GO:0006910)2.78338155
108oocyte development (GO:0048599)2.77366841
109regulation of protein polyubiquitination (GO:1902914)2.77117992
110protein localization to chromosome, centromeric region (GO:0071459)2.75884790
111centriole assembly (GO:0098534)2.75772367
112resolution of meiotic recombination intermediates (GO:0000712)2.75399824
113phosphatidylethanolamine metabolic process (GO:0046337)2.75173739
114DNA replication-dependent nucleosome organization (GO:0034723)2.74699970
115DNA replication-dependent nucleosome assembly (GO:0006335)2.74699970
116adult feeding behavior (GO:0008343)2.73212560
117cilium morphogenesis (GO:0060271)2.72541990
118protein K48-linked deubiquitination (GO:0071108)2.71713547
119protein refolding (GO:0042026)2.71299985
120centriole replication (GO:0007099)2.69380325
121microtubule polymerization or depolymerization (GO:0031109)2.68882178
122N-terminal protein amino acid acetylation (GO:0006474)2.67052481
123negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.65336798
124protein localization to Golgi apparatus (GO:0034067)2.64927672
125detection of light stimulus involved in visual perception (GO:0050908)2.60448758
126detection of light stimulus involved in sensory perception (GO:0050962)2.60448758
127coenzyme catabolic process (GO:0009109)2.58943022
128reciprocal DNA recombination (GO:0035825)2.54784166
129reciprocal meiotic recombination (GO:0007131)2.54784166
130cellular ketone body metabolic process (GO:0046950)2.50967458
131negative regulation of Rho protein signal transduction (GO:0035024)2.49516513
132Golgi to endosome transport (GO:0006895)2.48074145
133imidazole-containing compound metabolic process (GO:0052803)2.46926665
134relaxation of smooth muscle (GO:0044557)2.44231666
135fusion of sperm to egg plasma membrane (GO:0007342)13.4989914
136cilium or flagellum-dependent cell motility (GO:0001539)13.4115097
137sperm motility (GO:0030317)11.8969591
138acrosome assembly (GO:0001675)11.1664921
139multicellular organism reproduction (GO:0032504)10.8095966
140sperm-egg recognition (GO:0035036)10.7685483
141cell wall macromolecule catabolic process (GO:0016998)10.4962154
142cell wall macromolecule metabolic process (GO:0044036)10.4962154
143plasma membrane fusion (GO:0045026)10.2403429
144axonemal dynein complex assembly (GO:0070286)10.1107778
145acrosome reaction (GO:0007340)10.0343478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.68823874
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.39405491
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.49492670
4GBX2_23144817_ChIP-Seq_PC3_Human3.33339843
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.29454881
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68748308
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.55942715
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54240046
9FUS_26573619_Chip-Seq_HEK293_Human2.48944909
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46936149
11TAF15_26573619_Chip-Seq_HEK293_Human2.46665426
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41994711
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35809558
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.33690591
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31680563
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29281978
17IGF1R_20145208_ChIP-Seq_DFB_Human2.27879521
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26058850
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.17205663
20* P300_19829295_ChIP-Seq_ESCs_Human2.15497777
21* FLI1_27457419_Chip-Seq_LIVER_Mouse2.15104827
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.10222937
23ELK4_26923725_Chip-Seq_MESODERM_Mouse2.04420258
24VDR_22108803_ChIP-Seq_LS180_Human2.01917866
25* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.2206544
26SMAD4_21799915_ChIP-Seq_A2780_Human1.96006672
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91474764
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.90581874
29STAT3_23295773_ChIP-Seq_U87_Human1.86977889
30* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82164867
31ER_23166858_ChIP-Seq_MCF-7_Human1.82079526
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77915632
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.76612572
34ZNF274_21170338_ChIP-Seq_K562_Hela1.72887639
35CJUN_26792858_Chip-Seq_BT549_Human1.69178765
36* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.66537668
37* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66058488
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65694976
39AR_25329375_ChIP-Seq_VCAP_Human1.64031543
40FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63987484
41* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63443339
42TCF4_23295773_ChIP-Seq_U87_Human1.62879902
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62377580
44TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.57473867
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.57205533
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54871838
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.54582989
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.53824278
49* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.53519951
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52515788
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52428441
52EWS_26573619_Chip-Seq_HEK293_Human1.50564077
53BCAT_22108803_ChIP-Seq_LS180_Human1.48946339
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.47490136
55AR_21572438_ChIP-Seq_LNCaP_Human1.47413591
56MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47126514
57GATA1_22025678_ChIP-Seq_K562_Human1.46611466
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45525569
59GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.45182704
60GATA3_21867929_ChIP-Seq_CD8_Mouse1.45135545
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.44612918
62* SMAD4_21741376_ChIP-Seq_EPCs_Human1.44458770
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.43553859
64* STAT1_17558387_ChIP-Seq_HELA_Human1.41527770
65CDX2_22108803_ChIP-Seq_LS180_Human1.40537733
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40021968
67TP53_18474530_ChIP-ChIP_U2OS_Human1.39583493
68SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.38663320
69RUNX2_22187159_ChIP-Seq_PCA_Human1.38092637
70* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37839988
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.37548562
72SOX2_22085726_ChIP-Seq_NPCs_Mouse1.37190205
73* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34892365
74RNF2_27304074_Chip-Seq_NSC_Mouse1.34247123
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33952091
76* EZH2_27294783_Chip-Seq_NPCs_Mouse1.33294372
77BRD4_25478319_ChIP-Seq_HGPS_Human1.32432374
78TP53_16413492_ChIP-PET_HCT116_Human1.31858594
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31787815
80CBP_20019798_ChIP-Seq_JUKART_Human1.31787815
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31694418
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31693452
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.30179049
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29642611
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28961701
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28183597
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28172445
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27078147
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27018633
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26096391
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.25517677
92FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22976414
93AHR_22903824_ChIP-Seq_MCF-7_Human1.22022034
94LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.20955759
95GATA3_21867929_ChIP-Seq_TH1_Mouse1.20592518
96* NANOG_19829295_ChIP-Seq_ESCs_Human1.19934818
97* SOX2_19829295_ChIP-Seq_ESCs_Human1.19934818
98RUNX1_26923725_Chip-Seq_HPCs_Mouse1.19251504
99* NFE2_27457419_Chip-Seq_LIVER_Mouse1.15939741
100SPI1_26923725_Chip-Seq_HPCs_Mouse1.15718695
101KDM2B_26808549_Chip-Seq_REH_Human1.15293583
102TP63_23658742_ChIP-Seq_EP156T_Human1.14717602
103REST_21632747_ChIP-Seq_MESCs_Mouse1.14607762
104ESET_19884257_ChIP-Seq_ESCs_Mouse1.13736772
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13687008
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13565912
107YY1_22570637_ChIP-Seq_MALME-3M_Human1.13433558
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12287180
109RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11658759
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10633740
111P53_21459846_ChIP-Seq_SAOS-2_Human1.10223889
112SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10220088
113GF1_26923725_Chip-Seq_HPCs_Mouse1.09740127
114TBL1_22424771_ChIP-Seq_293T_Human1.09714342
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09089667
116NFYB_21822215_ChIP-Seq_K562_Human1.08646191
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08644272
118TCF4_22108803_ChIP-Seq_LS180_Human1.08059280
119CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07783636
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07777046
121* E2F1_18555785_Chip-Seq_ESCs_Mouse1.07512479
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07416311
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07416311
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.07213970
125CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06647370
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06392691
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06257267
128* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05523277
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04739846
130STAT3_18555785_ChIP-Seq_MESCs_Mouse1.04431460
131NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04266437
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.03758349
133RXR_22108803_ChIP-Seq_LS180_Human1.02759928
134HTT_18923047_ChIP-ChIP_STHdh_Human1.02486614
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02285970
136RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01446719
137ERG_20517297_ChIP-Seq_VCAP_Human1.01266818
138PHF8_20622853_ChIP-Seq_HELA_Human1.01055976
139* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00897337
140EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00504924
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99924703
142AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99909722
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.98769827
144* STAT3_18555785_Chip-Seq_ESCs_Mouse0.98506198
145* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98485039
146* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97910042
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97713168
148* OCT4_18555785_Chip-Seq_ESCs_Mouse0.95618272
149MYC_27129775_Chip-Seq_CORNEA_Mouse0.94702495
150LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94623585
151SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94169179
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.94022859
153GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93190720
154FLI1_21867929_ChIP-Seq_CD8_Mouse0.90190366
155CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89868738
156RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89345962
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88896046
158* KLF4_18555785_Chip-Seq_ESCs_Mouse0.88283576
159EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87382278
160SOX2_21211035_ChIP-Seq_LN229_Human0.86935923
161* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.86372724
162MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85826497
163NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85649246
164* CRX_20693478_ChIP-Seq_RETINA_Mouse0.85142974
165* NANOG_18555785_Chip-Seq_ESCs_Mouse0.84566259
166E2F1_17053090_ChIP-ChIP_MCF-7_Human0.84450267
167PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83777085
168NANOG_20526341_ChIP-Seq_ESCs_Human0.83624693
169FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83564108
170FOXA1_25329375_ChIP-Seq_VCAP_Human0.83564108
171PHF8_20622854_ChIP-Seq_HELA_Human0.83074748
172* P300_18555785_Chip-Seq_ESCs_Mouse0.81232846
173GF1B_26923725_Chip-Seq_HPCs_Mouse0.80882648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.84864705
2MP0001929_abnormal_gametogenesis5.43342789
3MP0008877_abnormal_DNA_methylation5.11202435
4MP0003718_maternal_effect4.41667689
5MP0002210_abnormal_sex_determination3.77165421
6MP0002653_abnormal_ependyma_morphology3.60328364
7MP0002822_catalepsy3.30477993
8MP0001145_abnormal_male_reproductive3.22974229
9MP0002161_abnormal_fertility/fecundity3.15894167
10MP0000653_abnormal_sex_gland2.73941670
11MP0008004_abnormal_stomach_pH2.59390752
12MP0005171_absent_coat_pigmentation2.51760390
13MP0009780_abnormal_chondrocyte_physiolo2.46971595
14MP0005395_other_phenotype2.41823925
15MP0010368_abnormal_lymphatic_system2.41027890
16MP0008057_abnormal_DNA_replication2.25750533
17MP0003011_delayed_dark_adaptation2.20559150
18MP0005174_abnormal_tail_pigmentation2.12174817
19MP0005623_abnormal_meninges_morphology2.10995109
20MP0005410_abnormal_fertilization14.7719659
21MP0002837_dystrophic_cardiac_calcinosis1.94725559
22MP0002160_abnormal_reproductive_system1.86978235
23MP0005503_abnormal_tendon_morphology1.85025617
24MP0005670_abnormal_white_adipose1.84167058
25MP0003136_yellow_coat_color1.73199707
26MP0004084_abnormal_cardiac_muscle1.69848068
27MP0004036_abnormal_muscle_relaxation1.56933124
28MP0008438_abnormal_cutaneous_collagen1.49085372
29MP0000015_abnormal_ear_pigmentation1.48318058
30MP0008058_abnormal_DNA_repair1.42098002
31MP0000372_irregular_coat_pigmentation1.41398592
32MP0010094_abnormal_chromosome_stability1.35938021
33MP0006054_spinal_hemorrhage1.35614185
34MP0004215_abnormal_myocardial_fiber1.33473237
35MP0002735_abnormal_chemical_nociception1.29100978
36MP0002282_abnormal_trachea_morphology1.18314647
37MP0003879_abnormal_hair_cell1.16927131
38MP0002168_other_aberrant_phenotype1.14299146
39MP0005275_abnormal_skin_tensile1.13666832
40MP0009250_abnormal_appendicular_skeleto1.12395618
41MP0003646_muscle_fatigue1.08741411
42MP0003693_abnormal_embryo_hatching1.08684982
43MP0005647_abnormal_sex_gland1.07486116
44MP0001879_abnormal_lymphatic_vessel1.07141241
45MP0003786_premature_aging1.05476021
46MP0004085_abnormal_heartbeat1.05386193
47MP0004264_abnormal_extraembryonic_tissu1.03740767
48MP0006276_abnormal_autonomic_nervous1.03309975
49MP0004145_abnormal_muscle_electrophysio1.02280142
50MP0002272_abnormal_nervous_system1.02160826
51MP0000749_muscle_degeneration1.01536420
52MP0009046_muscle_twitch1.00720111
53MP0008995_early_reproductive_senescence1.00155900
54MP0000534_abnormal_ureter_morphology0.99268812
55MP0003195_calcinosis0.98811762
56MP0000427_abnormal_hair_cycle0.95438651
57MP0001485_abnormal_pinna_reflex0.94743190
58MP0005389_reproductive_system_phenotype0.93423781
59MP0010386_abnormal_urinary_bladder0.93232970
60MP0004233_abnormal_muscle_weight0.92430107
61MP0003137_abnormal_impulse_conducting0.92051081
62MP0002102_abnormal_ear_morphology0.90726115
63MP0004272_abnormal_basement_membrane0.90091930
64MP0008007_abnormal_cellular_replicative0.90055873
65MP0000751_myopathy0.88240860
66MP0001984_abnormal_olfaction0.88127666
67MP0008775_abnormal_heart_ventricle0.88083645
68MP0001501_abnormal_sleep_pattern0.85571413
69MP0002229_neurodegeneration0.85020604
70MP0001765_abnormal_ion_homeostasis0.84465010
71MP0010678_abnormal_skin_adnexa0.84071711
72MP0003890_abnormal_embryonic-extraembry0.83977261
73MP0001968_abnormal_touch/_nociception0.83016335
74MP0003937_abnormal_limbs/digits/tail_de0.82903932
75MP0005408_hypopigmentation0.82146735
76MP0001958_emphysema0.81858765
77MP0001293_anophthalmia0.81002562
78MP0010234_abnormal_vibrissa_follicle0.80553718
79MP0000516_abnormal_urinary_system0.79825230
80MP0005367_renal/urinary_system_phenotyp0.79825230
81MP0003111_abnormal_nucleus_morphology0.77827902
82MP0002095_abnormal_skin_pigmentation0.75920374
83MP0005423_abnormal_somatic_nervous0.75611863
84MP0003806_abnormal_nucleotide_metabolis0.74727570
85MP0000358_abnormal_cell_content/0.74460010
86MP0001664_abnormal_digestion0.74102022
87MP0003045_fibrosis0.73995717
88MP0002108_abnormal_muscle_morphology0.73352299
89MP0000371_diluted_coat_color0.71484639
90MP0006035_abnormal_mitochondrial_morpho0.71156906
91MP0000383_abnormal_hair_follicle0.69920238
92MP0005620_abnormal_muscle_contractility0.69595219
93MP0003936_abnormal_reproductive_system0.69502169
94MP0004924_abnormal_behavior0.69446115
95MP0005386_behavior/neurological_phenoty0.69446115
96MP0005330_cardiomyopathy0.68798379
97MP0003252_abnormal_bile_duct0.68316592
98MP0003959_abnormal_lean_body0.68254640
99MP0004484_altered_response_of0.67999635
100MP0003385_abnormal_body_wall0.67554325
101MP0001986_abnormal_taste_sensitivity0.67391219
102MP0001299_abnormal_eye_distance/0.66541649
103MP0002254_reproductive_system_inflammat0.66193085
104MP0003880_abnormal_central_pattern0.65576957
105MP0003950_abnormal_plasma_membrane0.62155434
106MP0003077_abnormal_cell_cycle0.61451090
107MP0005075_abnormal_melanosome_morpholog0.61160323
108MP0001672_abnormal_embryogenesis/_devel0.57920772
109MP0005380_embryogenesis_phenotype0.57920772
110MP0005391_vision/eye_phenotype0.57387375
111MP0005253_abnormal_eye_physiology0.57200468
112MP0001730_embryonic_growth_arrest0.56318920
113MP0004957_abnormal_blastocyst_morpholog0.56020682
114MP0008961_abnormal_basal_metabolism0.55574759
115MP0005499_abnormal_olfactory_system0.55424251
116MP0005394_taste/olfaction_phenotype0.55424251
117MP0002092_abnormal_eye_morphology0.53703937
118MP0001324_abnormal_eye_pigmentation0.53378408
119MP0003984_embryonic_growth_retardation0.50693861
120MP0002269_muscular_atrophy0.49943772
121MP0003699_abnormal_female_reproductive0.49438383
122MP0002088_abnormal_embryonic_growth/wei0.49062038
123MP0005377_hearing/vestibular/ear_phenot0.48558081
124MP0003878_abnormal_ear_physiology0.48558081
125MP0000313_abnormal_cell_death0.48543452
126MP0002234_abnormal_pharynx_morphology0.48206450
127MP0001119_abnormal_female_reproductive0.47569139
128MP0002084_abnormal_developmental_patter0.46210031
129MP0003183_abnormal_peptide_metabolism0.45305057
130MP0003115_abnormal_respiratory_system0.45103270
131MP0004043_abnormal_pH_regulation0.44370382
132MP0002928_abnormal_bile_duct0.44070032
133MP0004808_abnormal_hematopoietic_stem0.43507960
134MP0006036_abnormal_mitochondrial_physio0.41286587
135MP0001849_ear_inflammation0.40892769
136MP0001545_abnormal_hematopoietic_system0.39980476
137MP0005397_hematopoietic_system_phenotyp0.39980476
138MP0005551_abnormal_eye_electrophysiolog0.39909716
139MP0010307_abnormal_tumor_latency0.38804962
140MP0009115_abnormal_fat_cell0.37448773
141MP0002970_abnormal_white_adipose0.37391454
142MP0002132_abnormal_respiratory_system0.37218142
143MP0003861_abnormal_nervous_system0.36794516
144MP0002085_abnormal_embryonic_tissue0.36533045
145MP0004133_heterotaxia0.35501019
146MP0005636_abnormal_mineral_homeostasis0.35369083
147MP0005666_abnormal_adipose_tissue0.35196206
148MP0000569_abnormal_digit_pigmentation0.34080426
149MP0001697_abnormal_embryo_size0.33814089
150MP0000432_abnormal_head_morphology0.33765267
151MP0005266_abnormal_metabolism0.30759344
152MP0006292_abnormal_olfactory_placode0.30440552
153MP0005257_abnormal_intraocular_pressure0.30173778
154MP0002114_abnormal_axial_skeleton0.29696308
155MP0004197_abnormal_fetal_growth/weight/0.29049507
156MP0002080_prenatal_lethality0.28627919
157MP0004134_abnormal_chest_morphology0.28114567
158MP0001727_abnormal_embryo_implantation0.27689127
159MP0002332_abnormal_exercise_endurance0.26905772
160MP0004858_abnormal_nervous_system0.26763065
161MP0009278_abnormal_bone_marrow0.26012654
162MP0006082_CNS_inflammation0.25914380
163MP0003121_genomic_imprinting0.25674726
164MP0001348_abnormal_lacrimal_gland0.25394763
165MP0002127_abnormal_cardiovascular_syste0.25149957
166MP0002233_abnormal_nose_morphology0.25149929
167MP0003942_abnormal_urinary_system0.24821823
168MP0000350_abnormal_cell_proliferation0.24564376
169MP0003787_abnormal_imprinting0.24391028
170MP0002086_abnormal_extraembryonic_tissu0.23219694

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.21052843
2Abnormal respiratory epithelium morphology (HP:0012253)8.63173650
3Abnormal respiratory motile cilium morphology (HP:0005938)8.63173650
4Rhinitis (HP:0012384)7.72953478
5Abnormal ciliary motility (HP:0012262)7.46369070
6Chronic bronchitis (HP:0004469)7.24417793
7Nasal polyposis (HP:0100582)6.74629622
8Volvulus (HP:0002580)6.52721454
9Infertility (HP:0000789)6.10071266
10Abnormality of the nasal mucosa (HP:0000433)5.52674587
11Bronchitis (HP:0012387)4.45379904
12Bronchiectasis (HP:0002110)4.43062185
13Severe visual impairment (HP:0001141)4.42254060
14Nephronophthisis (HP:0000090)4.13149239
15Abnormality of the lower motor neuron (HP:0002366)4.08451343
16Truncal obesity (HP:0001956)3.92723924
17Chronic hepatic failure (HP:0100626)3.80444068
18Hypoplastic ischia (HP:0003175)3.53765471
19Male infertility (HP:0003251)3.42144724
20Recurrent sinusitis (HP:0011108)3.29943361
21Abnormality of the ischium (HP:0003174)3.26709802
22Recurrent otitis media (HP:0000403)3.16008570
23Abnormality of the renal medulla (HP:0100957)3.13219417
24Pancreatic cysts (HP:0001737)3.11590624
25Abnormal spermatogenesis (HP:0008669)3.11380165
26Pancreatic fibrosis (HP:0100732)3.10803467
27Chromsome breakage (HP:0040012)3.09640147
28Amyotrophic lateral sclerosis (HP:0007354)2.99268430
29Metaphyseal dysplasia (HP:0100255)2.97724986
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96881849
31Cone-rod dystrophy (HP:0000548)2.85985624
32Horizontal nystagmus (HP:0000666)2.85574402
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.83802472
34Impulsivity (HP:0100710)2.82587310
35Gonadotropin excess (HP:0000837)2.82040820
36Bony spicule pigmentary retinopathy (HP:0007737)2.81744589
37Molar tooth sign on MRI (HP:0002419)2.78633527
38Abnormality of midbrain morphology (HP:0002418)2.78633527
39Gaze-evoked nystagmus (HP:0000640)2.64945394
40Hyperkalemia (HP:0002153)2.64663534
41Attenuation of retinal blood vessels (HP:0007843)2.63870094
42True hermaphroditism (HP:0010459)2.63298921
43Tubulointerstitial nephritis (HP:0001970)2.62194613
44Recurrent bronchitis (HP:0002837)2.59354644
45Ectopic kidney (HP:0000086)2.57315010
46Hypophosphatemic rickets (HP:0004912)2.53390719
47Facial diplegia (HP:0001349)2.51508788
48Medial flaring of the eyebrow (HP:0010747)2.50629094
49Oligodactyly (hands) (HP:0001180)2.47356295
50Congenital sensorineural hearing impairment (HP:0008527)2.45764156
51Upper limb muscle weakness (HP:0003484)2.45150164
52Occipital encephalocele (HP:0002085)2.43520739
53Scotoma (HP:0000575)2.42913083
54Abnormality of the nasal septum (HP:0000419)2.40453405
55Azoospermia (HP:0000027)2.38121914
56Short tibia (HP:0005736)2.34982669
57Striae distensae (HP:0001065)2.34461304
58Tubular atrophy (HP:0000092)2.31730369
59Osteomalacia (HP:0002749)2.28901166
60Abnormality of macular pigmentation (HP:0008002)2.23819565
61Impaired proprioception (HP:0010831)2.21888345
62Male pseudohermaphroditism (HP:0000037)2.21871488
63Aplasia/Hypoplasia of the earlobes (HP:0009906)2.20356406
64Prominent supraorbital ridges (HP:0000336)2.20313492
65Fibular hypoplasia (HP:0003038)2.18429496
66Atrial fibrillation (HP:0005110)2.17989509
67Tubulointerstitial abnormality (HP:0001969)2.17066377
68Upper motor neuron abnormality (HP:0002127)2.13971128
69Blepharitis (HP:0000498)2.11327366
70Supernumerary spleens (HP:0009799)2.10184798
71Hypoplasia of the fovea (HP:0007750)2.09370179
72Aplasia/Hypoplasia of the fovea (HP:0008060)2.09370179
73Postaxial foot polydactyly (HP:0001830)2.07079868
74Follicular hyperkeratosis (HP:0007502)2.03319161
75Spastic tetraparesis (HP:0001285)2.02137223
76Enlarged epiphyses (HP:0010580)2.01328940
77Facial cleft (HP:0002006)2.00899125
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3927378
79Absent/shortened dynein arms (HP:0200106)12.4152080
80Dynein arm defect of respiratory motile cilia (HP:0012255)12.4152080
81Thyroid-stimulating hormone excess (HP:0002925)1.97207243
82Absent frontal sinuses (HP:0002688)1.93176602
83Abnormality of the fovea (HP:0000493)1.92113616
84Central scotoma (HP:0000603)1.92084993
85Anencephaly (HP:0002323)1.91773597
86Hypoalphalipoproteinemia (HP:0003233)1.88676984
87Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87902252
88Glucose intolerance (HP:0000833)1.87425541
89Sclerocornea (HP:0000647)1.86916454
90Hypokinesia (HP:0002375)1.86687179
91Congenital hepatic fibrosis (HP:0002612)1.86311039
92Dyschromatopsia (HP:0007641)1.85395603
93Primary atrial arrhythmia (HP:0001692)1.85254576
94Abnormal rod and cone electroretinograms (HP:0008323)1.85018718
95Increased corneal curvature (HP:0100692)1.78827355
96Keratoconus (HP:0000563)1.78827355
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.78687465
98Oculomotor apraxia (HP:0000657)1.78284053
99Intellectual disability, moderate (HP:0002342)1.78281440
100Bile duct proliferation (HP:0001408)1.76960918
101Abnormal biliary tract physiology (HP:0012439)1.76960918
102Preaxial hand polydactyly (HP:0001177)1.76416406
103Heterotopia (HP:0002282)1.75758331
104Short ribs (HP:0000773)1.74025348
105Nephroblastoma (Wilms tumor) (HP:0002667)1.73041558
106Stage 5 chronic kidney disease (HP:0003774)1.72018805
107Highly arched eyebrow (HP:0002553)1.70190679
108Supraventricular tachycardia (HP:0004755)1.69318174
109Small intestinal stenosis (HP:0012848)1.67592530
110Duodenal stenosis (HP:0100867)1.67592530
111Tubulointerstitial fibrosis (HP:0005576)1.67540248
112Postaxial hand polydactyly (HP:0001162)1.67267537
113Widely spaced teeth (HP:0000687)1.67062966
114Convex nasal ridge (HP:0000444)1.66595218
115Abnormality of the renal collecting system (HP:0004742)1.65751224
116Degeneration of anterior horn cells (HP:0002398)1.65501744
117Abnormality of the anterior horn cell (HP:0006802)1.65501744
118Cardiovascular calcification (HP:0011915)1.63761601
119Abnormality of dentin (HP:0010299)1.62452454
120Abnormality of the dental root (HP:0006486)1.62429283
121Taurodontia (HP:0000679)1.62429283
122Abnormality of permanent molar morphology (HP:0011071)1.62429283
123Supraventricular arrhythmia (HP:0005115)1.61634696
124Ventricular fibrillation (HP:0001663)1.61439073
125Abnormality of the ileum (HP:0001549)1.61082607
126Embryonal renal neoplasm (HP:0011794)1.59649001
127Renal dysplasia (HP:0000110)1.58467040
128Abnormality of the renal cortex (HP:0011035)1.58045183
129Cholecystitis (HP:0001082)1.52701782
130Abnormal gallbladder physiology (HP:0012438)1.52701782
131Congenital primary aphakia (HP:0007707)1.50442552
132Abnormal drinking behavior (HP:0030082)1.50069517
133Polydipsia (HP:0001959)1.50069517
134Microglossia (HP:0000171)1.49478389
135Gait imbalance (HP:0002141)1.49332699
136Abnormality of molar (HP:0011077)1.49255702
137Abnormality of molar morphology (HP:0011070)1.49255702
138Abnormality of the dental pulp (HP:0006479)1.45560600
139Absent epiphyses (HP:0010577)1.44788641
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.44788641
141Short thorax (HP:0010306)1.44270033
142Chronic sinusitis (HP:0011109)1.41200760
143Bilateral microphthalmos (HP:0007633)1.38812301
144Bifid tongue (HP:0010297)1.38290019
145J-shaped sella turcica (HP:0002680)1.38128611
146Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.38114620
147Abnormality of renal excretion (HP:0011036)1.35174387
148Aplasia/Hypoplasia of the fibula (HP:0006492)1.34909813
149Sloping forehead (HP:0000340)1.34869392
150Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.33395803
15111 pairs of ribs (HP:0000878)1.31099023
152Difficulty walking (HP:0002355)1.30955486
153Abnormality of ocular smooth pursuit (HP:0000617)1.30170905
154Bell-shaped thorax (HP:0001591)1.29167430
155Short humerus (HP:0005792)1.28733782
156Cystic liver disease (HP:0006706)1.28358595
157Sensory axonal neuropathy (HP:0003390)1.28035416
158Nephrogenic diabetes insipidus (HP:0009806)1.27759169
159Hemiparesis (HP:0001269)1.27658864
160Median cleft lip (HP:0000161)1.27398769
161Aplasia/Hypoplasia of the lens (HP:0008063)1.26167191
162Abnormality of the phalanges of the hallux (HP:0010057)1.25856935
163Selective tooth agenesis (HP:0001592)1.24728811
164Deformed sella turcica (HP:0002681)1.22996500
165Hypopigmentation of the fundus (HP:0007894)1.22879850
166Atrophy/Degeneration involving motor neurons (HP:0007373)1.22052822
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.19403852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.67329268
2PDK38.67329268
3PDK25.63130570
4MAP3K94.97027994
5TESK14.60911493
6FRK4.53198994
7PRKD33.85203247
8ICK3.35769116
9DDR22.74088844
10PLK22.72685783
11ACVR1B2.69795777
12BRAF2.33388330
13ARAF2.20750919
14CDK122.19793987
15PTK2B2.18147878
16WNK42.14499620
17STK392.05661532
18PNCK2.04337141
19MAP4K21.92033966
20NEK21.89993597
21TAF11.70843966
22NEK91.68888110
23MAP3K131.59815999
24TRIM281.53382736
25TYRO31.52031229
26MET1.46687382
27WNK11.44037281
28STK381.43192187
29MARK11.41423421
30ERBB31.40200604
31PIK3CG1.39512965
32FGFR31.27282984
33TTK1.23750730
34NUAK11.22691064
35EIF2AK31.19086845
36LIMK11.12700552
37DYRK1B1.08877002
38GRK51.08230115
39PRKCI1.06556709
40OXSR10.95891894
41CDC70.94776046
42MST1R0.93397517
43MAP3K20.91708837
44PDK10.90629195
45RAF10.85371131
46STK30.84132909
47CHEK20.81981172
48MAPK150.81796789
49FER0.79650696
50PKN10.79603554
51DYRK30.77924513
52CCNB10.76729819
53ROCK10.76710200
54MKNK10.75184007
55ERN10.72556661
56PASK0.72105785
57INSRR0.72063881
58ZAK0.70912602
59WEE10.69150546
60MAPK130.68329269
61CHEK10.68272599
62GRK60.67769730
63MYLK0.67524424
64PRKCE0.66492984
65GRK10.66124206
66CSF1R0.64799544
67MAP2K60.59833037
68CDK90.57806449
69IRAK10.57378178
70EPHA40.55693352
71PLK30.54996029
72ADRBK20.53340401
73KSR20.52897180
74CASK0.52148321
75TRPM70.51340080
76FGFR10.51161588
77PLK10.50238168
78TESK20.49783925
79LATS10.49338234
80ATR0.49199101
81NTRK30.47040233
82PINK10.47036436
83MARK20.46044423
84STK100.45959491
85MAP3K40.45065033
86LMTK20.44736625
87DMPK0.44018948
88ATM0.43871770
89CAMK2A0.43691388
90BRD40.43559992
91MAP3K30.43516177
92CDK80.42893611
93CAMK1G0.41607997
94STK38L0.41529130
95MELK0.41112457
96PLK40.40656989
97MTOR0.38890962
98TAOK10.38690874
99TGFBR10.37992438
100CSNK1G10.37651593
101PAK10.34289501
102TNIK0.33952231
103PRKG20.31247203
104MAP2K10.31078374
105MAPK70.30787946
106CSNK1G20.29965035
107CSNK1A1L0.29325776
108MAP3K100.28543037
109PDPK10.28320020
110NTRK20.28228311
111TGFBR20.28127704
112PAK40.28051742
113MST40.28002820
114GRK70.27738148
115PAK30.27269619
116MATK0.26517786
117BCR0.25179349
118PRKAA10.23220574
119PRKCG0.23103329
120CDK70.20470832
121BMPR1B0.19724864
122IRAK20.19713137
123EEF2K0.19623577
124BRSK20.18623293
125PAK20.16905501
126CDK20.15634410
127MUSK0.13402147
128CSK0.13282127
129CDK10.12212961
130MOS0.10800098
131GSK3B0.09629913
132RPS6KB10.08845295
133NTRK10.08434546
134CSNK1D0.07526393
135RIPK40.07087363
136CDK150.06553471
137PRKACG0.06425542
138MAP2K40.06145526
139WNK30.05935381
140CSNK2A10.04983121
141CAMKK10.04830813
142CDK40.04712645
143MAPK80.04557819
144PRKACB0.04528026
145AURKA0.04032199
146CDK180.03847159
147RIPK10.03838979
148CDK11A0.03494282
149BRSK10.03412556
150ADRBK10.02528492
151NEK60.02397363
152MAPK100.02157926
153CAMK40.02017075
154MARK30.01816006
155BUB10.01431525
156MAPKAPK50.00749144
157PRKCQ0.00594632
158PRKG10.00560553
159AKT30.00244199
160EGFR0.00100826

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.11629238
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.13826339
3Pyruvate metabolism_Homo sapiens_hsa006203.69401926
4Fatty acid biosynthesis_Homo sapiens_hsa000613.01875180
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.95766653
6Basal transcription factors_Homo sapiens_hsa030222.92985204
7Linoleic acid metabolism_Homo sapiens_hsa005912.89352279
8Propanoate metabolism_Homo sapiens_hsa006402.79512833
9Fanconi anemia pathway_Homo sapiens_hsa034602.64928038
10Selenocompound metabolism_Homo sapiens_hsa004502.53511549
11Glucagon signaling pathway_Homo sapiens_hsa049222.47598553
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45450538
13Olfactory transduction_Homo sapiens_hsa047402.37073757
14Pentose phosphate pathway_Homo sapiens_hsa000302.34601893
15Dorso-ventral axis formation_Homo sapiens_hsa043202.25790465
16Fructose and mannose metabolism_Homo sapiens_hsa000512.19111826
17Non-homologous end-joining_Homo sapiens_hsa034502.15681213
18ECM-receptor interaction_Homo sapiens_hsa045122.14622168
19Oocyte meiosis_Homo sapiens_hsa041141.90136460
20Glycerolipid metabolism_Homo sapiens_hsa005611.88029042
21Folate biosynthesis_Homo sapiens_hsa007901.72799186
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69021523
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.67449775
24mRNA surveillance pathway_Homo sapiens_hsa030151.66007779
25Phototransduction_Homo sapiens_hsa047441.64092640
26RNA transport_Homo sapiens_hsa030131.62704775
27PPAR signaling pathway_Homo sapiens_hsa033201.50965649
28Huntingtons disease_Homo sapiens_hsa050161.48276317
29Circadian rhythm_Homo sapiens_hsa047101.46126207
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.45858652
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44452059
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.40436145
33Nucleotide excision repair_Homo sapiens_hsa034201.38910908
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.38806475
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37958435
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36149105
37Carbon metabolism_Homo sapiens_hsa012001.33766523
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33376636
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33236182
40Ether lipid metabolism_Homo sapiens_hsa005651.31353044
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.30555177
42Sphingolipid metabolism_Homo sapiens_hsa006001.25429510
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25138343
44Butanoate metabolism_Homo sapiens_hsa006501.22267950
45Amphetamine addiction_Homo sapiens_hsa050311.17513908
46Arachidonic acid metabolism_Homo sapiens_hsa005901.15156760
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15097482
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.13517663
49Nicotine addiction_Homo sapiens_hsa050331.11983483
50Regulation of autophagy_Homo sapiens_hsa041401.11856170
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11131843
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10994990
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09909344
54Salivary secretion_Homo sapiens_hsa049701.08847694
55Mismatch repair_Homo sapiens_hsa034301.08012677
56Dilated cardiomyopathy_Homo sapiens_hsa054141.07874301
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06076082
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05656792
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05399629
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04930039
61Renin secretion_Homo sapiens_hsa049241.04536111
62Cardiac muscle contraction_Homo sapiens_hsa042601.03712344
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03228330
64Antigen processing and presentation_Homo sapiens_hsa046120.99385917
65Fat digestion and absorption_Homo sapiens_hsa049750.95419271
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93544556
67TGF-beta signaling pathway_Homo sapiens_hsa043500.91418315
68Purine metabolism_Homo sapiens_hsa002300.91357985
69Focal adhesion_Homo sapiens_hsa045100.90687620
70mTOR signaling pathway_Homo sapiens_hsa041500.89587501
71Biosynthesis of amino acids_Homo sapiens_hsa012300.88109238
72Mineral absorption_Homo sapiens_hsa049780.84016970
73Morphine addiction_Homo sapiens_hsa050320.82153658
74Chemical carcinogenesis_Homo sapiens_hsa052040.80576647
75One carbon pool by folate_Homo sapiens_hsa006700.79764266
76Lysine degradation_Homo sapiens_hsa003100.78283308
77Fatty acid metabolism_Homo sapiens_hsa012120.76795256
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76009246
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.74266424
80Adherens junction_Homo sapiens_hsa045200.72542412
81Homologous recombination_Homo sapiens_hsa034400.71505071
82Long-term potentiation_Homo sapiens_hsa047200.67564657
83Inositol phosphate metabolism_Homo sapiens_hsa005620.67052640
84Hedgehog signaling pathway_Homo sapiens_hsa043400.66521852
85ABC transporters_Homo sapiens_hsa020100.66149769
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65011436
87Fatty acid degradation_Homo sapiens_hsa000710.64273435
88GABAergic synapse_Homo sapiens_hsa047270.64071663
89Glutamatergic synapse_Homo sapiens_hsa047240.62510054
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60955004
91Glutathione metabolism_Homo sapiens_hsa004800.60928269
92RNA degradation_Homo sapiens_hsa030180.60589515
93Serotonergic synapse_Homo sapiens_hsa047260.59831863
94Gap junction_Homo sapiens_hsa045400.59402877
95Circadian entrainment_Homo sapiens_hsa047130.59332541
96Base excision repair_Homo sapiens_hsa034100.58533194
97Tryptophan metabolism_Homo sapiens_hsa003800.58380539
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57145110
99Cell cycle_Homo sapiens_hsa041100.56354604
100Synaptic vesicle cycle_Homo sapiens_hsa047210.56257021
101MicroRNAs in cancer_Homo sapiens_hsa052060.54279015
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53957511
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53481626
104Pancreatic secretion_Homo sapiens_hsa049720.53358482
105Calcium signaling pathway_Homo sapiens_hsa040200.53329819
106Melanoma_Homo sapiens_hsa052180.52338215
107VEGF signaling pathway_Homo sapiens_hsa043700.52289806
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51542211
109RNA polymerase_Homo sapiens_hsa030200.50661617
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50108914
111AMPK signaling pathway_Homo sapiens_hsa041520.49487028
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.47906468
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47505777
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47371349
115Caffeine metabolism_Homo sapiens_hsa002320.46626452
116Nitrogen metabolism_Homo sapiens_hsa009100.45191851
117Renin-angiotensin system_Homo sapiens_hsa046140.45160179
118Gastric acid secretion_Homo sapiens_hsa049710.44082241
119Estrogen signaling pathway_Homo sapiens_hsa049150.43758257
120Long-term depression_Homo sapiens_hsa047300.43426573
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42483617
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42421700
123Fatty acid elongation_Homo sapiens_hsa000620.42407644
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40069516
125Taste transduction_Homo sapiens_hsa047420.39569227
126Legionellosis_Homo sapiens_hsa051340.39481203
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.38392397
128Protein export_Homo sapiens_hsa030600.37363177
129Metabolic pathways_Homo sapiens_hsa011000.37243162
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33718252
131Bile secretion_Homo sapiens_hsa049760.32626848
132Endocytosis_Homo sapiens_hsa041440.32617166
133Protein digestion and absorption_Homo sapiens_hsa049740.29566396
134Pyrimidine metabolism_Homo sapiens_hsa002400.28751879
135Systemic lupus erythematosus_Homo sapiens_hsa053220.27932791
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.26587141
137Collecting duct acid secretion_Homo sapiens_hsa049660.26098302
138Wnt signaling pathway_Homo sapiens_hsa043100.24629368
139N-Glycan biosynthesis_Homo sapiens_hsa005100.24546685
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24190727
141Retinol metabolism_Homo sapiens_hsa008300.21762596
142DNA replication_Homo sapiens_hsa030300.20676865
143Galactose metabolism_Homo sapiens_hsa000520.20538011
144cAMP signaling pathway_Homo sapiens_hsa040240.18878076
145Basal cell carcinoma_Homo sapiens_hsa052170.18784244
146Viral carcinogenesis_Homo sapiens_hsa052030.17716267
147B cell receptor signaling pathway_Homo sapiens_hsa046620.17677793
148Insulin secretion_Homo sapiens_hsa049110.17580244
149Thyroid hormone synthesis_Homo sapiens_hsa049180.17080621
150Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16475167
151Ovarian steroidogenesis_Homo sapiens_hsa049130.11926120
152Spliceosome_Homo sapiens_hsa030400.11191159
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07564101
154T cell receptor signaling pathway_Homo sapiens_hsa046600.07170988

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