ALS2CR12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.96796515
2cilium movement (GO:0003341)9.69699788
3epithelial cilium movement (GO:0003351)9.61495399
4motile cilium assembly (GO:0044458)9.61345486
5piRNA metabolic process (GO:0034587)8.91093778
6cell-cell recognition (GO:0009988)8.89081779
7reproduction (GO:0000003)8.87252915
8binding of sperm to zona pellucida (GO:0007339)8.84747652
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.40490028
10regulation of cilium movement (GO:0003352)8.19455676
11male meiosis (GO:0007140)8.18254363
12acrosome reaction (GO:0007340)7.90721136
13spermatid development (GO:0007286)7.69361471
14ventricular system development (GO:0021591)7.47897928
15single fertilization (GO:0007338)7.16071627
16synaptonemal complex organization (GO:0070193)7.14886658
17synaptonemal complex assembly (GO:0007130)7.02034491
18microtubule severing (GO:0051013)6.56457106
19fertilization (GO:0009566)5.94569453
20sperm capacitation (GO:0048240)5.91062970
21DNA methylation involved in gamete generation (GO:0043046)5.46213332
22behavioral response to nicotine (GO:0035095)5.01724281
23spermatogenesis (GO:0007283)4.98362475
24male gamete generation (GO:0048232)4.96579750
25protein localization to cilium (GO:0061512)4.93692696
26chromosome organization involved in meiosis (GO:0070192)4.89959863
27regulation of microtubule-based movement (GO:0060632)4.74131208
28male meiosis I (GO:0007141)4.73521902
29meiotic nuclear division (GO:0007126)4.60336212
30gamete generation (GO:0007276)4.57379684
31organic cation transport (GO:0015695)4.56267375
32cellular process involved in reproduction in multicellular organism (GO:0022412)4.53828678
33germ cell development (GO:0007281)4.39636572
34protein polyglutamylation (GO:0018095)4.36415539
35negative regulation of inclusion body assembly (GO:0090084)4.31861630
36intraciliary transport (GO:0042073)4.25405871
37cell recognition (GO:0008037)4.15331113
38meiotic cell cycle (GO:0051321)4.13181003
39microtubule depolymerization (GO:0007019)4.10146821
40seminiferous tubule development (GO:0072520)4.08695272
41axoneme assembly (GO:0035082)3.98194183
42L-fucose catabolic process (GO:0042355)3.96979631
43fucose catabolic process (GO:0019317)3.96979631
44L-fucose metabolic process (GO:0042354)3.96979631
45meiosis I (GO:0007127)3.92075232
46regulation of response to osmotic stress (GO:0047484)3.86581509
47GTP biosynthetic process (GO:0006183)3.82155606
48monoubiquitinated protein deubiquitination (GO:0035520)3.77321427
49genitalia morphogenesis (GO:0035112)3.76716493
50retinal cone cell development (GO:0046549)3.67900132
51nucleoside diphosphate phosphorylation (GO:0006165)3.67815244
52dopamine transport (GO:0015872)3.63612929
53cilium organization (GO:0044782)3.62832842
54multicellular organismal reproductive process (GO:0048609)3.59924316
55calcium ion-dependent exocytosis (GO:0017156)3.57753334
56regulation of inclusion body assembly (GO:0090083)3.54270039
57regulation of protein polyubiquitination (GO:1902914)3.53165427
58gene silencing by RNA (GO:0031047)3.52786296
59microtubule-based movement (GO:0007018)3.49465820
60UTP biosynthetic process (GO:0006228)3.48736775
61cilium morphogenesis (GO:0060271)3.46278308
62cilium assembly (GO:0042384)3.45642355
63negative regulation of telomere maintenance (GO:0032205)3.43156202
64spermatid nucleus differentiation (GO:0007289)3.43001995
65C21-steroid hormone biosynthetic process (GO:0006700)3.39354543
66neural tube formation (GO:0001841)3.34254606
67cellular component assembly involved in morphogenesis (GO:0010927)3.32074784
68left/right pattern formation (GO:0060972)3.29218751
69indolalkylamine metabolic process (GO:0006586)3.28856782
70activated T cell proliferation (GO:0050798)3.25531506
71nuclear pore complex assembly (GO:0051292)3.25245933
72progesterone metabolic process (GO:0042448)3.24059074
73tolerance induction (GO:0002507)3.22008984
74UTP metabolic process (GO:0046051)3.20633786
75response to pheromone (GO:0019236)3.18413431
76protein K11-linked deubiquitination (GO:0035871)3.15534587
77left/right axis specification (GO:0070986)3.15130475
78daunorubicin metabolic process (GO:0044597)3.10827583
79polyketide metabolic process (GO:0030638)3.10827583
80doxorubicin metabolic process (GO:0044598)3.10827583
81alditol metabolic process (GO:0019400)3.10250302
82centriole assembly (GO:0098534)3.07144800
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.07020351
84centriole replication (GO:0007099)3.01917701
85protein localization to chromosome, centromeric region (GO:0071459)2.98507999
86regulation of memory T cell differentiation (GO:0043380)2.97195350
87chaperone-mediated protein complex assembly (GO:0051131)2.97169516
88synapsis (GO:0007129)2.96278813
89regulation of centriole replication (GO:0046599)2.95112624
90multicellular organismal development (GO:0007275)2.93288096
91glycerol metabolic process (GO:0006071)2.92270582
92photoreceptor cell maintenance (GO:0045494)2.92001808
93amino-acid betaine transport (GO:0015838)2.85837106
94carnitine transport (GO:0015879)2.85837106
95microtubule bundle formation (GO:0001578)2.85747134
96carnitine transmembrane transport (GO:1902603)2.85365466
97negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.82812139
98meiotic cell cycle process (GO:1903046)2.81431797
99tryptophan catabolic process (GO:0006569)2.80455443
100indole-containing compound catabolic process (GO:0042436)2.80455443
101indolalkylamine catabolic process (GO:0046218)2.80455443
102regulation of germinal center formation (GO:0002634)2.79330830
103lactate metabolic process (GO:0006089)2.78390082
104glycolytic process (GO:0006096)2.77988178
105nonmotile primary cilium assembly (GO:0035058)2.75903984
106establishment of protein localization to Golgi (GO:0072600)2.74447174
107negative regulation of organelle assembly (GO:1902116)2.73418972
108detection of light stimulus involved in visual perception (GO:0050908)2.72343472
109detection of light stimulus involved in sensory perception (GO:0050962)2.72343472
110cornea development in camera-type eye (GO:0061303)2.71609453
111microglial cell activation (GO:0001774)2.71383864
112DNA deamination (GO:0045006)2.70208913
113negative regulation of necroptotic process (GO:0060546)2.69898244
114preassembly of GPI anchor in ER membrane (GO:0016254)2.68639841
115DNA replication-dependent nucleosome organization (GO:0034723)2.66672244
116DNA replication-dependent nucleosome assembly (GO:0006335)2.66672244
117glycerol ether metabolic process (GO:0006662)2.66460394
118rRNA catabolic process (GO:0016075)2.64374859
119tryptophan metabolic process (GO:0006568)2.63326568
120adaptation of signaling pathway (GO:0023058)2.62153002
121neuronal action potential (GO:0019228)2.60302958
122exogenous drug catabolic process (GO:0042738)2.59248040
123guanosine-containing compound biosynthetic process (GO:1901070)2.57969473
124regulation of meiosis I (GO:0060631)2.56394333
125cellular ketone body metabolic process (GO:0046950)2.53433104
126neuronal action potential propagation (GO:0019227)2.52938082
127primary amino compound metabolic process (GO:1901160)2.52033427
128retinal rod cell development (GO:0046548)2.51100840
129regulation of neurotransmitter uptake (GO:0051580)2.50976491
130regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.50585341
131regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.50585341
132protein targeting to Golgi (GO:0000042)2.50457474
133regulation of interleukin-6 biosynthetic process (GO:0045408)2.45366916
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.42895083
135indole-containing compound metabolic process (GO:0042430)2.41891370
136thyroid hormone metabolic process (GO:0042403)2.40765453
137regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.40407064
138negative regulation of interleukin-1 production (GO:0032692)2.40235999
139positive regulation of defense response to virus by host (GO:0002230)2.39840210
140negative regulation of systemic arterial blood pressure (GO:0003085)2.39101841
141negative regulation of mast cell activation (GO:0033004)2.38786324
142kynurenine metabolic process (GO:0070189)2.38234409
143amine catabolic process (GO:0009310)2.36226428
144cellular biogenic amine catabolic process (GO:0042402)2.36226428
145serotonin metabolic process (GO:0042428)2.33399702
146negative regulation of response to food (GO:0032096)2.31676908
147negative regulation of appetite (GO:0032099)2.31676908
148protein localization to Golgi apparatus (GO:0034067)2.31449947
149photoreceptor cell development (GO:0042461)2.30885984
150ketone body metabolic process (GO:1902224)2.30852929
151protein K63-linked deubiquitination (GO:0070536)2.29008569
152regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.28791610
153synaptic transmission, cholinergic (GO:0007271)2.28554656
154regulation of action potential (GO:0098900)2.27268852
155phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.25983389
156embryonic epithelial tube formation (GO:0001838)2.25848365
157nephron epithelium morphogenesis (GO:0072088)2.25165944
158nephron tubule morphogenesis (GO:0072078)2.25165944
159pyrimidine nucleobase catabolic process (GO:0006208)2.24826436
160negative regulation of T cell differentiation in thymus (GO:0033085)2.23881124
161membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.23126885
162regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.23017530
163negative regulation of neurotransmitter transport (GO:0051589)2.22924023
164cAMP catabolic process (GO:0006198)2.22738117
165response to xenobiotic stimulus (GO:0009410)2.22244683
166drug catabolic process (GO:0042737)2.21652952
167negative regulation of cAMP-mediated signaling (GO:0043951)2.21030363
168cilium or flagellum-dependent cell motility (GO:0001539)14.8091915
169fusion of sperm to egg plasma membrane (GO:0007342)13.6314322
170axonemal dynein complex assembly (GO:0070286)11.8147947
171acrosome assembly (GO:0001675)11.5658735
172multicellular organism reproduction (GO:0032504)11.0768059
173cell wall macromolecule metabolic process (GO:0044036)10.5813256
174cell wall macromolecule catabolic process (GO:0016998)10.5813256
175plasma membrane fusion (GO:0045026)10.2776366
176sperm motility (GO:0030317)10.1282297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.74492252
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.72119302
3EZH2_22144423_ChIP-Seq_EOC_Human2.79174050
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.79002164
5* FLI1_27457419_Chip-Seq_LIVER_Mouse2.61638993
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39218501
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34167710
8* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.29125890
9GBX2_23144817_ChIP-Seq_PC3_Human2.27895354
10KAP1_22055183_ChIP-Seq_ESCs_Mouse2.23559831
11ELK4_26923725_Chip-Seq_MESODERM_Mouse2.17119331
12KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.09350810
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06947120
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06396363
15* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.7183553
16* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.95907198
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.94044148
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91766714
19ER_23166858_ChIP-Seq_MCF-7_Human1.89733628
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89516755
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.87242263
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.84925713
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84532388
24CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.82025535
25RNF2_27304074_Chip-Seq_NSC_Mouse1.81245958
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81186456
27RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.66091266
28TAF15_26573619_Chip-Seq_HEK293_Human1.65941132
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64845258
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.63668194
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62895230
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62737612
33P300_19829295_ChIP-Seq_ESCs_Human1.61222126
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59338017
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57404774
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55141420
37TAL1_26923725_Chip-Seq_HPCs_Mouse1.54385166
38STAT3_23295773_ChIP-Seq_U87_Human1.51496373
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.49890286
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49324908
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.48207243
42BCAT_22108803_ChIP-Seq_LS180_Human1.47467653
43SMAD4_21799915_ChIP-Seq_A2780_Human1.46843644
44EWS_26573619_Chip-Seq_HEK293_Human1.46256853
45FUS_26573619_Chip-Seq_HEK293_Human1.45378399
46AR_21572438_ChIP-Seq_LNCaP_Human1.45267093
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44504980
48GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44162709
49TCF4_23295773_ChIP-Seq_U87_Human1.44013482
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43556067
51ZNF274_21170338_ChIP-Seq_K562_Hela1.43491517
52GATA3_21867929_ChIP-Seq_CD8_Mouse1.42852876
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.41008216
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39904074
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39428766
56SOX2_22085726_ChIP-Seq_NPCs_Mouse1.38879331
57TP53_22573176_ChIP-Seq_HFKS_Human1.38147709
58FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37495365
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.36350862
60CBP_20019798_ChIP-Seq_JUKART_Human1.36010712
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36010712
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.35658309
63* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.34780220
64REST_21632747_ChIP-Seq_MESCs_Mouse1.34681632
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.31724412
66AR_25329375_ChIP-Seq_VCAP_Human1.31040938
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30807888
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30230964
69VDR_22108803_ChIP-Seq_LS180_Human1.29575147
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28903626
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28569618
72* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26361959
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.26027125
74DROSHA_22980978_ChIP-Seq_HELA_Human1.25920722
75* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25195537
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25039473
77STAT1_17558387_ChIP-Seq_HELA_Human1.24482857
78SOX2_19829295_ChIP-Seq_ESCs_Human1.24468164
79NANOG_19829295_ChIP-Seq_ESCs_Human1.24468164
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24319894
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24221067
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24082686
83LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.23864875
84* ESET_19884257_ChIP-Seq_ESCs_Mouse1.23745065
85* EZH2_27294783_Chip-Seq_NPCs_Mouse1.23583792
86* NFE2_27457419_Chip-Seq_LIVER_Mouse1.23531346
87IRF1_19129219_ChIP-ChIP_H3396_Human1.23370832
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23133827
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22239901
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22239901
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22239901
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20257947
93* SPI1_26923725_Chip-Seq_HPCs_Mouse1.20013489
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19792028
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.19003603
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18955398
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17998413
98RUNX2_22187159_ChIP-Seq_PCA_Human1.17370905
99* OCT4_18555785_Chip-Seq_ESCs_Mouse1.16084585
100TCF4_22108803_ChIP-Seq_LS180_Human1.15591112
101RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15229447
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.15209607
103* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15036849
104ERG_20517297_ChIP-Seq_VCAP_Human1.13784835
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13281826
106GF1_26923725_Chip-Seq_HPCs_Mouse1.13235226
107* P53_22387025_ChIP-Seq_ESCs_Mouse1.12434961
108SMRT_27268052_Chip-Seq_Bcells_Human1.12391403
109YY1_22570637_ChIP-Seq_MALME-3M_Human1.12337465
110* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12298809
111GATA3_21867929_ChIP-Seq_TH1_Mouse1.12028867
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11978148
113GATA3_26560356_Chip-Seq_TH2_Human1.11758411
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11698695
115AR_20517297_ChIP-Seq_VCAP_Human1.11406615
116CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11172332
117* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11051207
118STAT3_18555785_ChIP-Seq_MESCs_Mouse1.10607954
119RUNX_20019798_ChIP-Seq_JUKART_Human1.10484899
120TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09559533
121KDM2B_26808549_Chip-Seq_REH_Human1.09293993
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09250043
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.08622932
124* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.07628504
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07605729
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.06079606
127KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04928775
128CDX2_22108803_ChIP-Seq_LS180_Human1.04773751
129* CRX_20693478_ChIP-Seq_RETINA_Mouse1.04729548
130FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04678857
131FOXA1_25329375_ChIP-Seq_VCAP_Human1.04678857
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04446450
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04221573
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04103464
135HOXB7_26014856_ChIP-Seq_BT474_Human1.03994277
136CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03200087
137* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03002973
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02766656
139* P53_21459846_ChIP-Seq_SAOS-2_Human1.02672316
140* KLF4_18555785_Chip-Seq_ESCs_Mouse1.02531384
141* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01749048
142LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01016480
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99976773
144* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99776205
145* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99717293
146NCOR_22424771_ChIP-Seq_293T_Human0.99477274
147SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99411385
148FOXH1_21741376_ChIP-Seq_EPCs_Human0.99404770
149ETV1_20927104_ChIP-Seq_GIST48_Human0.99337784
150* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98591784
151* P300_18555785_Chip-Seq_ESCs_Mouse0.98194790
152E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97673577
153* CMYC_18555785_Chip-Seq_ESCs_Mouse0.97561810
154RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97298985
155* STAT3_18555785_Chip-Seq_ESCs_Mouse0.94902940
156ELF1_20517297_ChIP-Seq_JURKAT_Human0.94824857
157EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94759573
158NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94643503
159ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94237803
160TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94009172
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94009172
162RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93977646
163RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93520125
164FLI1_21867929_ChIP-Seq_CD8_Mouse0.92685442
165RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92029811
166GF1B_26923725_Chip-Seq_HPCs_Mouse0.91839860
167IGF1R_20145208_ChIP-Seq_DFB_Human0.90913679
168* ZFX_18555785_Chip-Seq_ESCs_Mouse0.90279011
169* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89758900
170AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89240953
171* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88589061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.25212892
2MP0001929_abnormal_gametogenesis4.90182376
3MP0002653_abnormal_ependyma_morphology4.41722733
4MP0008877_abnormal_DNA_methylation4.18272434
5MP0000569_abnormal_digit_pigmentation3.65754970
6MP0003011_delayed_dark_adaptation3.62229931
7MP0002210_abnormal_sex_determination3.46691260
8MP0008057_abnormal_DNA_replication3.08041354
9MP0001145_abnormal_male_reproductive3.01391365
10MP0003787_abnormal_imprinting2.83883087
11MP0002161_abnormal_fertility/fecundity2.81842399
12MP0005623_abnormal_meninges_morphology2.74580176
13MP0005670_abnormal_white_adipose2.59361129
14MP0000653_abnormal_sex_gland2.57557824
15MP0003195_calcinosis2.54845198
16MP0008875_abnormal_xenobiotic_pharmacok2.42475952
17MP0002876_abnormal_thyroid_physiology2.32381358
18MP0004885_abnormal_endolymph2.18851865
19MP0002160_abnormal_reproductive_system2.13773949
20MP0005647_abnormal_sex_gland2.11114225
21MP0005551_abnormal_eye_electrophysiolog2.10089866
22MP0004142_abnormal_muscle_tone2.09661483
23MP0003724_increased_susceptibility_to2.05687853
24MP0005645_abnormal_hypothalamus_physiol2.01567447
25MP0002102_abnormal_ear_morphology2.01142635
26MP0005410_abnormal_fertilization12.8815330
27MP0008004_abnormal_stomach_pH1.94658662
28MP0005174_abnormal_tail_pigmentation1.85329818
29MP0008872_abnormal_physiological_respon1.80540163
30MP0004147_increased_porphyrin_level1.79450887
31MP0002837_dystrophic_cardiac_calcinosis1.78673205
32MP0008058_abnormal_DNA_repair1.74397652
33MP0001968_abnormal_touch/_nociception1.72051088
34MP0009745_abnormal_behavioral_response1.69700963
35MP0002638_abnormal_pupillary_reflex1.68281642
36MP0005646_abnormal_pituitary_gland1.62319567
37MP0001986_abnormal_taste_sensitivity1.62136965
38MP0004264_abnormal_extraembryonic_tissu1.60863578
39MP0002254_reproductive_system_inflammat1.56420032
40MP0002272_abnormal_nervous_system1.53670531
41MP0003656_abnormal_erythrocyte_physiolo1.52637415
42MP0002277_abnormal_respiratory_mucosa1.48359082
43MP0004742_abnormal_vestibular_system1.47191593
44MP0005671_abnormal_response_to1.46336652
45MP0006276_abnormal_autonomic_nervous1.44200521
46MP0003890_abnormal_embryonic-extraembry1.42663872
47MP0001835_abnormal_antigen_presentation1.39968032
48MP0001485_abnormal_pinna_reflex1.38037107
49MP0002909_abnormal_adrenal_gland1.35981073
50MP0002736_abnormal_nociception_after1.34359425
51MP0000372_irregular_coat_pigmentation1.34199504
52MP0000015_abnormal_ear_pigmentation1.32783506
53MP0009046_muscle_twitch1.29270316
54MP0003950_abnormal_plasma_membrane1.27345303
55MP0002928_abnormal_bile_duct1.21836369
56MP0005075_abnormal_melanosome_morpholog1.20455911
57MP0002282_abnormal_trachea_morphology1.20422315
58MP0000685_abnormal_immune_system1.19603220
59MP0010094_abnormal_chromosome_stability1.18300770
60MP0004883_abnormal_blood_vessel1.12498039
61MP0000383_abnormal_hair_follicle1.11310981
62MP0005666_abnormal_adipose_tissue1.09961284
63MP0005310_abnormal_salivary_gland1.09895618
64MP0001501_abnormal_sleep_pattern1.09739043
65MP0004133_heterotaxia1.09734829
66MP0001800_abnormal_humoral_immune1.08909734
67MP0003878_abnormal_ear_physiology1.08808742
68MP0005377_hearing/vestibular/ear_phenot1.08808742
69MP0005389_reproductive_system_phenotype1.08090722
70MP0002229_neurodegeneration1.07023037
71MP0003646_muscle_fatigue1.06513466
72MP0006072_abnormal_retinal_apoptosis1.06325122
73MP0002332_abnormal_exercise_endurance1.06007429
74MP0001970_abnormal_pain_threshold1.05532333
75MP0003880_abnormal_central_pattern1.05522650
76MP0002572_abnormal_emotion/affect_behav1.04474895
77MP0004145_abnormal_muscle_electrophysio1.02976927
78MP0008995_early_reproductive_senescence1.02008934
79MP0002067_abnormal_sensory_capabilities1.01983319
80MP0006035_abnormal_mitochondrial_morpho1.01794994
81MP0001919_abnormal_reproductive_system1.01376199
82MP0000631_abnormal_neuroendocrine_gland1.01320367
83MP0008007_abnormal_cellular_replicative1.00484138
84MP0002064_seizures1.00437882
85MP0005499_abnormal_olfactory_system0.98720221
86MP0005394_taste/olfaction_phenotype0.98720221
87MP0001188_hyperpigmentation0.98633903
88MP0002095_abnormal_skin_pigmentation0.98582251
89MP0002733_abnormal_thermal_nociception0.97649929
90MP0009764_decreased_sensitivity_to0.96167842
91MP0003121_genomic_imprinting0.96047274
92MP0000230_abnormal_systemic_arterial0.91691104
93MP0001486_abnormal_startle_reflex0.91529115
94MP0008789_abnormal_olfactory_epithelium0.91199941
95MP0002148_abnormal_hypersensitivity_rea0.89354302
96MP0000358_abnormal_cell_content/0.88721305
97MP0005084_abnormal_gallbladder_morpholo0.88604468
98MP0005386_behavior/neurological_phenoty0.88389497
99MP0004924_abnormal_behavior0.88389497
100MP0002163_abnormal_gland_morphology0.88233617
101MP0002970_abnormal_white_adipose0.88103327
102MP0003705_abnormal_hypodermis_morpholog0.87849433
103MP0009115_abnormal_fat_cell0.87073520
104MP0002063_abnormal_learning/memory/cond0.86918013
105MP0003635_abnormal_synaptic_transmissio0.86533389
106MP0001905_abnormal_dopamine_level0.86471280
107MP0002735_abnormal_chemical_nociception0.85178967
108MP0004484_altered_response_of0.83899853
109MP0001440_abnormal_grooming_behavior0.82288587
110MP0005387_immune_system_phenotype0.81973780
111MP0001790_abnormal_immune_system0.81973780
112MP0001765_abnormal_ion_homeostasis0.81602013
113MP0003252_abnormal_bile_duct0.81411115
114MP0010386_abnormal_urinary_bladder0.81237205
115MP0002693_abnormal_pancreas_physiology0.80742899
116MP0002557_abnormal_social/conspecific_i0.79848965
117MP0005195_abnormal_posterior_eye0.78161485
118MP0003786_premature_aging0.77987847
119MP0003283_abnormal_digestive_organ0.76040603
120MP0002723_abnormal_immune_serum0.75782968
121MP0004130_abnormal_muscle_cell0.75053888
122MP0006292_abnormal_olfactory_placode0.73922521
123MP0008961_abnormal_basal_metabolism0.73849713
124MP0001984_abnormal_olfaction0.73780429
125MP0001502_abnormal_circadian_rhythm0.72893775
126MP0002796_impaired_skin_barrier0.71218073
127MP0001672_abnormal_embryogenesis/_devel0.66538137
128MP0005380_embryogenesis_phenotype0.66538137
129MP0004858_abnormal_nervous_system0.66457077
130MP0005266_abnormal_metabolism0.66137520
131MP0004043_abnormal_pH_regulation0.65974771
132MP0004957_abnormal_blastocyst_morpholog0.62113477
133MP0002971_abnormal_brown_adipose0.61947262
134MP0003984_embryonic_growth_retardation0.59783245
135MP0006036_abnormal_mitochondrial_physio0.58483972
136MP0002088_abnormal_embryonic_growth/wei0.58326208
137MP0001119_abnormal_female_reproductive0.58250587
138MP0000678_abnormal_parathyroid_gland0.55971365
139MP0000427_abnormal_hair_cycle0.55919974
140MP0004381_abnormal_hair_follicle0.55494391
141MP0004019_abnormal_vitamin_homeostasis0.54666758
142MP0003045_fibrosis0.52102392
143MP0005253_abnormal_eye_physiology0.50076274
144MP0001293_anophthalmia0.49929183
145MP0001727_abnormal_embryo_implantation0.49665984
146MP0002127_abnormal_cardiovascular_syste0.49481363
147MP0002132_abnormal_respiratory_system0.49344819
148MP0005319_abnormal_enzyme/_coenzyme0.49180025
149MP0003699_abnormal_female_reproductive0.48996014
150MP0002084_abnormal_developmental_patter0.48562935
151MP0000313_abnormal_cell_death0.48061629
152MP0003183_abnormal_peptide_metabolism0.47650992
153MP0005391_vision/eye_phenotype0.46956610
154MP0000647_abnormal_sebaceous_gland0.46301441
155MP0002234_abnormal_pharynx_morphology0.46088592
156MP0000432_abnormal_head_morphology0.45800976
157MP0003136_yellow_coat_color0.45727008
158MP0002269_muscular_atrophy0.45438084
159MP0003077_abnormal_cell_cycle0.44140461
160MP0002092_abnormal_eye_morphology0.42944075
161MP0002114_abnormal_axial_skeleton0.42807091
162MP0010368_abnormal_lymphatic_system0.42549858
163MP0001730_embryonic_growth_arrest0.42454794
164MP0002233_abnormal_nose_morphology0.41252981
165MP0002085_abnormal_embryonic_tissue0.40901626
166MP0001324_abnormal_eye_pigmentation0.40890867
167MP0003111_abnormal_nucleus_morphology0.38939072
168MP0010352_gastrointestinal_tract_polyps0.38283253
169MP0001348_abnormal_lacrimal_gland0.37962200
170MP0004134_abnormal_chest_morphology0.37083992
171MP0005375_adipose_tissue_phenotype0.36175510
172MP0004233_abnormal_muscle_weight0.35311959
173MP0006082_CNS_inflammation0.35038583
174MP0005257_abnormal_intraocular_pressure0.34906536
175MP0005636_abnormal_mineral_homeostasis0.33871779
176MP0000609_abnormal_liver_physiology0.30476607
177MP0002116_abnormal_craniofacial_bone0.29582244
178MP0004185_abnormal_adipocyte_glucose0.28857613
179MP0002109_abnormal_limb_morphology0.28382607
180MP0002932_abnormal_joint_morphology0.26952638
181MP0010307_abnormal_tumor_latency0.25604180

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)8.85208883
2Abnormal respiratory epithelium morphology (HP:0012253)8.45725539
3Abnormal respiratory motile cilium morphology (HP:0005938)8.45725539
4Rhinitis (HP:0012384)8.22997252
5Chronic bronchitis (HP:0004469)7.44604662
6Nasal polyposis (HP:0100582)6.88517231
7Abnormality of the nasal mucosa (HP:0000433)5.61905605
8Infertility (HP:0000789)5.55881114
9Male infertility (HP:0003251)4.64699927
10Bronchiectasis (HP:0002110)4.63851791
11Abnormality of the lower motor neuron (HP:0002366)4.31310337
12Bronchitis (HP:0012387)4.15877228
13Congenital stationary night blindness (HP:0007642)3.63336453
14Chronic hepatic failure (HP:0100626)3.58707088
15Recurrent sinusitis (HP:0011108)3.42301198
16Nephronophthisis (HP:0000090)3.24599157
17Medial flaring of the eyebrow (HP:0010747)3.06754444
18Amyotrophic lateral sclerosis (HP:0007354)3.01443279
19Supernumerary spleens (HP:0009799)2.97614661
20Bile duct proliferation (HP:0001408)2.92398090
21Abnormal biliary tract physiology (HP:0012439)2.92398090
22Recurrent otitis media (HP:0000403)2.92063486
23Abnormal rod and cone electroretinograms (HP:0008323)2.86427687
24Tubulointerstitial nephritis (HP:0001970)2.77991130
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.76681687
26Genetic anticipation (HP:0003743)2.75261101
27Molar tooth sign on MRI (HP:0002419)2.69313207
28Abnormality of midbrain morphology (HP:0002418)2.69313207
29Decreased circulating renin level (HP:0003351)2.67650115
30Progressive cerebellar ataxia (HP:0002073)2.65286694
31Attenuation of retinal blood vessels (HP:0007843)2.61767275
32Type II lissencephaly (HP:0007260)2.59014048
33Renal cortical cysts (HP:0000803)2.53792520
34Hyperventilation (HP:0002883)2.52863408
35Gaze-evoked nystagmus (HP:0000640)2.50371012
36Stomatitis (HP:0010280)2.50211520
37Abolished electroretinogram (ERG) (HP:0000550)2.45888693
38Sclerocornea (HP:0000647)2.45179395
39Decreased central vision (HP:0007663)2.42772264
40Postaxial foot polydactyly (HP:0001830)2.39304273
41Abnormality of the renal medulla (HP:0100957)2.39129846
42Upper motor neuron abnormality (HP:0002127)2.37701103
43Congenital primary aphakia (HP:0007707)2.29740333
44Gait imbalance (HP:0002141)2.29059826
45Furrowed tongue (HP:0000221)2.23286001
46Fibular hypoplasia (HP:0003038)2.22732429
47Facial cleft (HP:0002006)2.13640777
48Pancreatic fibrosis (HP:0100732)2.11010591
49Abnormality of dentin (HP:0010299)2.10932106
50Elevated erythrocyte sedimentation rate (HP:0003565)2.10878323
51Constricted visual fields (HP:0001133)2.10689458
52Abnormality of macular pigmentation (HP:0008002)2.10537268
53Congenital hepatic fibrosis (HP:0002612)2.08682258
54Abnormal spermatogenesis (HP:0008669)2.00366145
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7127745
56Absent/shortened dynein arms (HP:0200106)11.2394788
57Dynein arm defect of respiratory motile cilia (HP:0012255)11.2394788
58Abnormal respiratory motile cilium physiology (HP:0012261)10.1934481
59Tubulointerstitial abnormality (HP:0001969)1.98829140
60Aplasia/Hypoplasia of the spleen (HP:0010451)1.97969157
61Nephrogenic diabetes insipidus (HP:0009806)1.96962821
62True hermaphroditism (HP:0010459)1.96938772
63Recurrent bronchitis (HP:0002837)1.96725605
64Gonadotropin excess (HP:0000837)1.95846803
65Abnormality of the dental root (HP:0006486)1.95615518
66Taurodontia (HP:0000679)1.95615518
67Abnormality of permanent molar morphology (HP:0011071)1.95615518
68Stomach cancer (HP:0012126)1.94487035
69Hypothermia (HP:0002045)1.94231331
70Occipital encephalocele (HP:0002085)1.94044092
71Febrile seizures (HP:0002373)1.93164500
72Tubular atrophy (HP:0000092)1.92302709
73Cystic liver disease (HP:0006706)1.92281747
74Oculomotor apraxia (HP:0000657)1.88337651
75Bony spicule pigmentary retinopathy (HP:0007737)1.87223521
76Asplenia (HP:0001746)1.86967168
77Chronic sinusitis (HP:0011109)1.85764773
78Retrobulbar optic neuritis (HP:0100654)1.85241165
79Optic neuritis (HP:0100653)1.85241165
80Absent speech (HP:0001344)1.84242364
81Abnormality of molar (HP:0011077)1.84100613
82Abnormality of molar morphology (HP:0011070)1.84100613
83Polyuria (HP:0000103)1.83776504
84Lissencephaly (HP:0001339)1.83422481
85Impaired proprioception (HP:0010831)1.83151345
86Impulsivity (HP:0100710)1.81861852
87Concave nail (HP:0001598)1.79492768
88Congenital, generalized hypertrichosis (HP:0004540)1.79239490
89Broad-based gait (HP:0002136)1.79062447
90Nephroblastoma (Wilms tumor) (HP:0002667)1.79054188
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79015895
92Abnormality of alanine metabolism (HP:0010916)1.79015895
93Hyperalaninemia (HP:0003348)1.79015895
94Retinitis pigmentosa (HP:0000510)1.77579865
95Pendular nystagmus (HP:0012043)1.77124031
96Poor coordination (HP:0002370)1.74881277
97Large for gestational age (HP:0001520)1.74022229
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73657643
99Abnormality of the dental pulp (HP:0006479)1.73021594
100IgG deficiency (HP:0004315)1.72867475
101Postaxial hand polydactyly (HP:0001162)1.72436858
102Tongue fasciculations (HP:0001308)1.72403416
103Aplasia/Hypoplasia of the tongue (HP:0010295)1.71467382
104Azoospermia (HP:0000027)1.70463751
105Cerebellar dysplasia (HP:0007033)1.70458384
106Pachygyria (HP:0001302)1.69644345
107Bilateral microphthalmos (HP:0007633)1.68521717
108Severe muscular hypotonia (HP:0006829)1.66517160
109Abnormality of the corticospinal tract (HP:0002492)1.65386272
110Embryonal renal neoplasm (HP:0011794)1.65363553
111Agitation (HP:0000713)1.64803278
112Disproportionate short-trunk short stature (HP:0003521)1.64714559
113Oligodactyly (hands) (HP:0001180)1.64684845
114Chronic otitis media (HP:0000389)1.64167789
115Male pseudohermaphroditism (HP:0000037)1.64158115
116Broad distal phalanx of finger (HP:0009836)1.63798640
117Optic disc pallor (HP:0000543)1.63509798
118Absent frontal sinuses (HP:0002688)1.62007958
119Abnormality of renin-angiotensin system (HP:0000847)1.60692014
120Widely spaced teeth (HP:0000687)1.58192277
121Increased corneal curvature (HP:0100692)1.57663915
122Keratoconus (HP:0000563)1.57663915
123Muscle fibrillation (HP:0010546)1.56905186
124Pancreatic cysts (HP:0001737)1.55935025
125Hyperkalemia (HP:0002153)1.55903709
126Spastic tetraparesis (HP:0001285)1.53070802
127Degeneration of the lateral corticospinal tracts (HP:0002314)1.52750539
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.52750539
129Genital tract atresia (HP:0001827)1.50806299
130Stage 5 chronic kidney disease (HP:0003774)1.50725777
131Vaginal atresia (HP:0000148)1.49917725
132Bifid tongue (HP:0010297)1.46637679
133Short thorax (HP:0010306)1.43804934
134Abnormality of the renal cortex (HP:0011035)1.41612242
135Short ribs (HP:0000773)1.40735835
136Broad foot (HP:0001769)1.38650401
13711 pairs of ribs (HP:0000878)1.37170359
138Anencephaly (HP:0002323)1.36809562
139Sloping forehead (HP:0000340)1.36778121
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.35848137
141Aplasia/Hypoplasia of the lens (HP:0008063)1.35287337
142Median cleft lip (HP:0000161)1.34428968
143Aplasia/Hypoplasia of the fibula (HP:0006492)1.33092863
144Atrophy/Degeneration involving motor neurons (HP:0007373)1.26245689
145Short nail (HP:0001799)1.25540718
146Abnormality of the anterior horn cell (HP:0006802)1.25270513
147Degeneration of anterior horn cells (HP:0002398)1.25270513
148Tubulointerstitial fibrosis (HP:0005576)1.25120475
149Short humerus (HP:0005792)1.24099877
150Microglossia (HP:0000171)1.22413873
151Disinhibition (HP:0000734)1.22334717
152Abnormality of the phalanges of the hallux (HP:0010057)1.16553279
153Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.16278936
154Abnormal drinking behavior (HP:0030082)1.14114060
155Polydipsia (HP:0001959)1.14114060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.75991147
2PDK48.75991147
3PDK25.74531234
4FRK4.55369165
5CDK123.34821382
6TAOK33.28963972
7BMPR1B2.96366478
8TXK2.87568210
9TESK12.69369850
10ACVR1B2.43069521
11TLK12.39894875
12GRK12.29816635
13PTK2B2.14037262
14GRK52.10096377
15MAP4K22.03298116
16WNK31.93103651
17PRKD31.89396022
18NUAK11.81423118
19WNK41.80912086
20PNCK1.75550027
21STK391.73829107
22ICK1.69837039
23TRPM71.69537172
24OXSR11.65461326
25PLK21.57740758
26ERN11.55533072
27TYRO31.55376598
28TTK1.52675551
29MAPK131.50919387
30GRK61.49740777
31WNK11.45385801
32DAPK21.40778140
33ZAK1.38099304
34MST41.36192357
35TEC1.34684139
36INSRR1.32012841
37NEK21.31211773
38IKBKE1.26709305
39PAK31.25022195
40ADRBK21.24143922
41MAPK151.21017586
42WEE11.14668157
43SYK1.14482072
44MAP3K41.14282311
45CAMKK21.12004970
46CASK1.05053632
47KIT1.05013972
48SGK21.04297452
49STK100.99491117
50CSF1R0.97390990
51SIK20.95153678
52IKBKB0.94744256
53STK380.93910593
54ERBB20.92890216
55TGFBR10.90300999
56STK110.89974587
57PRKG20.88408044
58CDK190.88212132
59EEF2K0.88008329
60CHEK20.85544337
61MAP2K20.85211036
62STK30.84344074
63MAPKAPK30.78991795
64IRAK40.78665307
65PIK3CG0.77148673
66PHKG10.76915900
67PHKG20.76915900
68MARK30.76741335
69PDK10.76329834
70TGFBR20.75809194
71STK38L0.75045662
72PRKCE0.73479505
73PIM10.70447652
74BRSK20.70241672
75SGK4940.68880517
76SGK2230.68880517
77MAPK70.68444363
78MAP2K70.68314301
79LMTK20.68002503
80CHUK0.67994246
81TNIK0.67477379
82EPHA30.67476685
83BTK0.67206227
84PRKCQ0.64981347
85MAP2K10.64858761
86CDC70.63330045
87GRK70.62256871
88CHEK10.61705555
89NLK0.60302244
90MAP2K60.59942261
91DYRK20.59888924
92LYN0.59765234
93MOS0.59243821
94PRKCI0.56932736
95PLK10.55774953
96DYRK1A0.55759663
97LCK0.54891208
98NTRK20.54443971
99RIPK40.53600234
100FLT30.53188571
101MATK0.52253277
102PRKD20.51487955
103SGK10.51348228
104PKN10.51093869
105LATS10.50623895
106LATS20.49213778
107CAMK10.48737095
108PRKCZ0.48735973
109SGK30.48432848
110DYRK30.47543820
111DYRK1B0.47208013
112RPS6KA50.45484013
113PIK3CA0.44273802
114CAMK2A0.43410450
115MAP3K70.43205960
116PRKG10.41719590
117CDK70.38821710
118PASK0.38695423
119MARK20.38606819
120CAMK1G0.37855521
121PRKCG0.37409735
122AKT30.37373798
123CCNB10.36207984
124PLK40.35991782
125NME10.35802704
126CAMKK10.35612186
127PINK10.34880822
128RPS6KA60.33733270
129NTRK30.33394052
130ATM0.33352668
131CSNK1G20.33280382
132ABL10.32654619
133MAPKAPK50.32190617
134IRAK10.31272686
135NTRK10.30741381
136MTOR0.29307193
137PAK40.29060610
138TESK20.28956397
139CDC42BPA0.28290193
140PAK10.28224919
141ATR0.27393016
142MAP3K100.24933314
143AURKA0.24133231
144PRKAA10.23766207
145ADRBK10.23545661
146CSK0.22436686
147BRSK10.20789376
148PRKACG0.20340926
149MUSK0.19530510
150MAP2K40.17944558
151FGFR30.15720413
152IGF1R0.14972182
153CAMK40.14606968
154EIF2AK20.14427255
155ITK0.10363802
156MST1R0.10094867
157PDPK10.09956446
158TNK20.09660503
159CDK10.09316666
160BMPR20.08644752
161CDK20.08384585
162BRAF0.07422509
163GSK3A0.07110861
164INSR0.07080191
165RIPK10.06863130
166MAPK80.06774972
167RPS6KB10.05562563
168CDK40.04984246
169MAPK10.03743330
170MAPK100.02747060
171PRKACA0.02591411
172CSNK1E0.02302257
173PRKAA20.02127493
174EPHA20.02117727
175RPS6KA30.01852347
176PRKCD0.01713163

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.53207022
2Pyruvate metabolism_Homo sapiens_hsa006203.99526857
3Propanoate metabolism_Homo sapiens_hsa006403.90327221
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.44759572
5Pentose phosphate pathway_Homo sapiens_hsa000302.86242664
6Phototransduction_Homo sapiens_hsa047442.78314187
7Fanconi anemia pathway_Homo sapiens_hsa034602.67675552
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.65712862
9Linoleic acid metabolism_Homo sapiens_hsa005912.57429249
10Fatty acid biosynthesis_Homo sapiens_hsa000612.49637319
11Nitrogen metabolism_Homo sapiens_hsa009102.44771717
12Nicotine addiction_Homo sapiens_hsa050332.30123774
13PPAR signaling pathway_Homo sapiens_hsa033202.25144666
14Basal transcription factors_Homo sapiens_hsa030222.22741889
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10124458
16Fructose and mannose metabolism_Homo sapiens_hsa000512.07404152
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06809896
18Glucagon signaling pathway_Homo sapiens_hsa049222.04052264
19Glycerolipid metabolism_Homo sapiens_hsa005612.01404483
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98407460
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95342982
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.95206190
23Carbon metabolism_Homo sapiens_hsa012001.88202156
24Selenocompound metabolism_Homo sapiens_hsa004501.87313173
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84891955
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.82285430
27Butanoate metabolism_Homo sapiens_hsa006501.80703909
28Huntingtons disease_Homo sapiens_hsa050161.79346685
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75540485
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74778747
31Regulation of autophagy_Homo sapiens_hsa041401.67782565
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66341448
33Oxidative phosphorylation_Homo sapiens_hsa001901.65773141
34Caffeine metabolism_Homo sapiens_hsa002321.61971009
35Arachidonic acid metabolism_Homo sapiens_hsa005901.60536445
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57337732
37Morphine addiction_Homo sapiens_hsa050321.54735068
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52189193
39Olfactory transduction_Homo sapiens_hsa047401.48333116
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.48118509
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.47804396
42Allograft rejection_Homo sapiens_hsa053301.45397769
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42728313
44Type I diabetes mellitus_Homo sapiens_hsa049401.40883805
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.36850414
46Oocyte meiosis_Homo sapiens_hsa041141.35835502
47Asthma_Homo sapiens_hsa053101.35822167
48Primary immunodeficiency_Homo sapiens_hsa053401.34875792
49Dorso-ventral axis formation_Homo sapiens_hsa043201.34792061
50Graft-versus-host disease_Homo sapiens_hsa053321.30676265
51Parkinsons disease_Homo sapiens_hsa050121.30392858
52Ovarian steroidogenesis_Homo sapiens_hsa049131.29132512
53Serotonergic synapse_Homo sapiens_hsa047261.26937435
54Glycerophospholipid metabolism_Homo sapiens_hsa005641.21292018
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20675234
56Fat digestion and absorption_Homo sapiens_hsa049751.13096745
57Biosynthesis of amino acids_Homo sapiens_hsa012301.10269776
58Autoimmune thyroid disease_Homo sapiens_hsa053201.06139348
59Ether lipid metabolism_Homo sapiens_hsa005651.03676527
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03092032
61Chemical carcinogenesis_Homo sapiens_hsa052041.02031930
62RNA transport_Homo sapiens_hsa030131.01313129
63NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01054998
64Hematopoietic cell lineage_Homo sapiens_hsa046400.99628919
65Fatty acid degradation_Homo sapiens_hsa000710.99105530
66Histidine metabolism_Homo sapiens_hsa003400.98343440
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97779443
68GABAergic synapse_Homo sapiens_hsa047270.97739871
69Salivary secretion_Homo sapiens_hsa049700.97700981
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96221909
71Alzheimers disease_Homo sapiens_hsa050100.95836723
72Circadian entrainment_Homo sapiens_hsa047130.94261170
73Fatty acid metabolism_Homo sapiens_hsa012120.93064573
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91944959
75Glutathione metabolism_Homo sapiens_hsa004800.91129052
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90852797
77Glutamatergic synapse_Homo sapiens_hsa047240.88178164
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87815073
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87795823
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.86230926
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84488031
82Renin secretion_Homo sapiens_hsa049240.83692561
83Insulin secretion_Homo sapiens_hsa049110.82988853
84Renin-angiotensin system_Homo sapiens_hsa046140.81920919
85Mineral absorption_Homo sapiens_hsa049780.80040700
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78266681
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78256667
88T cell receptor signaling pathway_Homo sapiens_hsa046600.78238673
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.76814733
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76310034
91mRNA surveillance pathway_Homo sapiens_hsa030150.76041313
92Purine metabolism_Homo sapiens_hsa002300.74484566
93African trypanosomiasis_Homo sapiens_hsa051430.72881697
94Dopaminergic synapse_Homo sapiens_hsa047280.69669645
95Cardiac muscle contraction_Homo sapiens_hsa042600.69001361
96beta-Alanine metabolism_Homo sapiens_hsa004100.68196858
97Inositol phosphate metabolism_Homo sapiens_hsa005620.66657023
98Rheumatoid arthritis_Homo sapiens_hsa053230.66353199
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65048800
100Homologous recombination_Homo sapiens_hsa034400.63553114
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63063556
102Cholinergic synapse_Homo sapiens_hsa047250.62123411
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61916659
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61276312
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60513316
106RNA polymerase_Homo sapiens_hsa030200.57716139
107Protein export_Homo sapiens_hsa030600.57553107
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56588856
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.55611447
110Cocaine addiction_Homo sapiens_hsa050300.55315065
111Metabolic pathways_Homo sapiens_hsa011000.55097846
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54835321
113Long-term depression_Homo sapiens_hsa047300.54565449
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54220009
115Malaria_Homo sapiens_hsa051440.53934021
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53190216
117ABC transporters_Homo sapiens_hsa020100.52194470
118Leishmaniasis_Homo sapiens_hsa051400.51967205
119Circadian rhythm_Homo sapiens_hsa047100.51100329
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51098791
121Antigen processing and presentation_Homo sapiens_hsa046120.51088751
122Oxytocin signaling pathway_Homo sapiens_hsa049210.50995003
123AMPK signaling pathway_Homo sapiens_hsa041520.50963038
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.50960285
125Retinol metabolism_Homo sapiens_hsa008300.48681300
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46816114
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.44945561
128Cell cycle_Homo sapiens_hsa041100.42916878
129Amphetamine addiction_Homo sapiens_hsa050310.42835754
130Galactose metabolism_Homo sapiens_hsa000520.41644510
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40739395
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40587416
133Collecting duct acid secretion_Homo sapiens_hsa049660.37823586
134VEGF signaling pathway_Homo sapiens_hsa043700.37107933
135Calcium signaling pathway_Homo sapiens_hsa040200.36581553
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36517230
137Protein digestion and absorption_Homo sapiens_hsa049740.34425582
138RNA degradation_Homo sapiens_hsa030180.34195870
139Base excision repair_Homo sapiens_hsa034100.29759879
140Pyrimidine metabolism_Homo sapiens_hsa002400.29264633
141Complement and coagulation cascades_Homo sapiens_hsa046100.26652813
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24282697
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23340868
144Tight junction_Homo sapiens_hsa045300.22491688
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22490244
146Legionellosis_Homo sapiens_hsa051340.19102054
147Tryptophan metabolism_Homo sapiens_hsa003800.17940756
148Hedgehog signaling pathway_Homo sapiens_hsa043400.17823610
149p53 signaling pathway_Homo sapiens_hsa041150.17219204
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.16064374
151Long-term potentiation_Homo sapiens_hsa047200.15516007
152Bile secretion_Homo sapiens_hsa049760.14340351
153Taste transduction_Homo sapiens_hsa047420.13153508
154Sulfur metabolism_Homo sapiens_hsa009200.10755432
155Wnt signaling pathway_Homo sapiens_hsa043100.08891791
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08584646
157Nucleotide excision repair_Homo sapiens_hsa034200.07889871
158Vascular smooth muscle contraction_Homo sapiens_hsa042700.07332835
159Peroxisome_Homo sapiens_hsa041460.06435411
160Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.06101486
161Estrogen signaling pathway_Homo sapiens_hsa049150.05925487
162Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.05128026
163cAMP signaling pathway_Homo sapiens_hsa040240.04702137
164Sphingolipid metabolism_Homo sapiens_hsa006000.04037611
165Endocytosis_Homo sapiens_hsa041440.04021517

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