ALX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1substrate-dependent cell migration (GO:0006929)6.88156033
2cell migration involved in heart development (GO:0060973)5.23995511
3regulation of glucose import in response to insulin stimulus (GO:2001273)5.22401540
4head development (GO:0060322)5.17119429
5paraxial mesoderm development (GO:0048339)5.13989753
6chondrocyte proliferation (GO:0035988)5.13484540
7induction of positive chemotaxis (GO:0050930)5.02077592
8negative regulation of glucose import (GO:0046325)5.01951192
9endocardial cushion morphogenesis (GO:0003203)4.97931037
10notochord development (GO:0030903)4.89100627
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.67356489
12epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.61924918
13cellular protein complex localization (GO:0034629)4.49004920
14protein complex localization (GO:0031503)4.41726051
15planar cell polarity pathway involved in neural tube closure (GO:0090179)4.39517564
16histone H3-K36 demethylation (GO:0070544)4.31865949
17mesenchyme morphogenesis (GO:0072132)4.30919322
18bone trabecula formation (GO:0060346)4.27641236
19positive regulation of neuroblast proliferation (GO:0002052)4.22863094
20outer ear morphogenesis (GO:0042473)4.19351837
21regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.10537473
22adherens junction assembly (GO:0034333)4.09824888
23interkinetic nuclear migration (GO:0022027)4.06540378
24aorta morphogenesis (GO:0035909)4.06303192
25negative regulation of erythrocyte differentiation (GO:0045647)4.00776694
26cell surface receptor signaling pathway involved in heart development (GO:0061311)3.99386910
27focal adhesion assembly (GO:0048041)3.98452721
28cell-substrate adherens junction assembly (GO:0007045)3.98452721
29regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.94499154
30negative regulation of DNA repair (GO:0045738)3.93152812
31mesenchymal cell proliferation (GO:0010463)3.90450435
32craniofacial suture morphogenesis (GO:0097094)3.85112218
33lateral sprouting from an epithelium (GO:0060601)3.84349230
34cell proliferation involved in metanephros development (GO:0072203)3.82887510
353-UTR-mediated mRNA stabilization (GO:0070935)3.82252427
36establishment of planar polarity (GO:0001736)3.82023474
37establishment of tissue polarity (GO:0007164)3.82023474
38cellular response to leptin stimulus (GO:0044320)3.78920867
39Notch signaling involved in heart development (GO:0061314)3.78332812
40kidney mesenchyme development (GO:0072074)3.77313447
41regulation of NFAT protein import into nucleus (GO:0051532)3.75245732
42cranial suture morphogenesis (GO:0060363)3.74234764
43cardiac epithelial to mesenchymal transition (GO:0060317)3.73387362
44apoptotic process involved in morphogenesis (GO:0060561)3.72816327
45proximal/distal pattern formation (GO:0009954)3.71915332
46negative regulation of embryonic development (GO:0045992)3.71330907
47positive regulation of protein autophosphorylation (GO:0031954)3.71264103
48barbed-end actin filament capping (GO:0051016)3.69104490
49regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.68897941
50regulation of cellular senescence (GO:2000772)3.61837080
51mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.60417463
52negative regulation of glucose transport (GO:0010829)3.56232554
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.54793462
54* embryonic forelimb morphogenesis (GO:0035115)3.54330677
55negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.54188171
56mitotic chromosome condensation (GO:0007076)3.53312476
57regulation of heart morphogenesis (GO:2000826)3.52107623
58embryonic process involved in female pregnancy (GO:0060136)3.48187510
59negative regulation of cell fate specification (GO:0009996)3.47267832
60negative regulation of catenin import into nucleus (GO:0035414)3.47019905
61Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.46971020
62protein retention in ER lumen (GO:0006621)3.45895057
63positive regulation of blood vessel endothelial cell migration (GO:0043536)3.43239897
64* embryonic hindlimb morphogenesis (GO:0035116)3.42541166
65G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.41626286
66vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.40443762
67short-term memory (GO:0007614)3.39696224
68hippo signaling (GO:0035329)3.39479150
69epithelial to mesenchymal transition (GO:0001837)3.38187931
70maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.36730672
71middle ear morphogenesis (GO:0042474)3.35508160
72tooth mineralization (GO:0034505)3.34618163
73positive regulation of transcription regulatory region DNA binding (GO:2000679)3.34548064
74cartilage morphogenesis (GO:0060536)3.33395759
75regulation of establishment of planar polarity (GO:0090175)3.33354728
76* hindlimb morphogenesis (GO:0035137)3.32091959
77metanephric mesenchyme development (GO:0072075)3.31501963
78cardiac right ventricle morphogenesis (GO:0003215)3.24919479
79* embryonic appendage morphogenesis (GO:0035113)3.23571651
80* embryonic limb morphogenesis (GO:0030326)3.23571651
81* forelimb morphogenesis (GO:0035136)3.21627135
82cell proliferation involved in kidney development (GO:0072111)3.21550291
83negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.21058342
84cochlea morphogenesis (GO:0090103)3.20440110
85embryonic skeletal joint morphogenesis (GO:0060272)3.17698951
86positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.15620028
87embryonic cranial skeleton morphogenesis (GO:0048701)3.14852094
88pre-miRNA processing (GO:0031054)3.13761862
89regulation of ARF GTPase activity (GO:0032312)3.12698613
90mesenchymal cell development (GO:0014031)3.11868823
91mRNA cleavage (GO:0006379)3.09081033
92positive regulation of cartilage development (GO:0061036)3.07465127
93cell-substrate junction assembly (GO:0007044)3.06653028
94peptidyl-lysine dimethylation (GO:0018027)3.06478303
95polarized epithelial cell differentiation (GO:0030859)3.05733363
96collagen fibril organization (GO:0030199)3.05514690
97maternal placenta development (GO:0001893)3.05129821
98regulation of neuroblast proliferation (GO:1902692)3.04331841
99* limb morphogenesis (GO:0035108)3.04133755
100* appendage morphogenesis (GO:0035107)3.04133755
101negative regulation of homotypic cell-cell adhesion (GO:0034111)3.03285610
102non-canonical Wnt signaling pathway (GO:0035567)3.03220200
103basement membrane organization (GO:0071711)3.01607046
104cellular response to interleukin-6 (GO:0071354)3.00780953
105response to leptin (GO:0044321)2.98188411
106heterochromatin organization (GO:0070828)2.96891357
107negative regulation of inclusion body assembly (GO:0090084)2.96574510
108mesenchymal-epithelial cell signaling (GO:0060638)2.95834960
109outflow tract morphogenesis (GO:0003151)2.95006372
110negative regulation of chondrocyte differentiation (GO:0032331)2.92934057
111positive regulation of positive chemotaxis (GO:0050927)2.92375721
112nuclear pore complex assembly (GO:0051292)2.92228327
113mRNA transcription from RNA polymerase II promoter (GO:0042789)2.90690419
114negative regulation of defense response to virus (GO:0050687)2.89568129
115regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.89429576
116mannose metabolic process (GO:0006013)2.85509599
117artery morphogenesis (GO:0048844)2.83865200
118mesenchyme development (GO:0060485)2.82907187
119regulation of transcription regulatory region DNA binding (GO:2000677)2.82863588
120regulation of cell aging (GO:0090342)2.81772875
121dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.81691384
122positive regulation of epithelial to mesenchymal transition (GO:0010718)2.81656425
123positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.81486666
124cellular response to epidermal growth factor stimulus (GO:0071364)2.79966628
125negative regulation of necroptotic process (GO:0060546)2.79253133
126embryonic eye morphogenesis (GO:0048048)2.79234694
127neuron projection extension involved in neuron projection guidance (GO:1902284)2.79103545
128axon extension involved in axon guidance (GO:0048846)2.79103545
129morphogenesis of embryonic epithelium (GO:0016331)2.78963993
130neuronal stem cell maintenance (GO:0097150)2.77511586
131cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.77467288
132positive regulation of smoothened signaling pathway (GO:0045880)2.76530613
133regulation of positive chemotaxis (GO:0050926)2.76405733
134midgut development (GO:0007494)2.75910630
135eyelid development in camera-type eye (GO:0061029)2.75273550
136regulation of oxidative stress-induced neuron death (GO:1903203)2.72303612
137positive regulation of catecholamine secretion (GO:0033605)2.69765320
138Golgi transport vesicle coating (GO:0048200)2.69125621
139COPI coating of Golgi vesicle (GO:0048205)2.69125621
140mRNA stabilization (GO:0048255)2.68805327
141RNA stabilization (GO:0043489)2.68805327
142cortical actin cytoskeleton organization (GO:0030866)2.66735013
143atrioventricular valve morphogenesis (GO:0003181)2.66149605
144spliceosomal tri-snRNP complex assembly (GO:0000244)2.65072599
145negative regulation of stem cell proliferation (GO:2000647)2.64868865
146regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.64362660
147apoptotic process involved in development (GO:1902742)2.64256986
148TOR signaling (GO:0031929)2.62240424
149positive regulation of protein kinase C signaling (GO:0090037)2.60850128
150lymph vessel development (GO:0001945)2.59657023
151retrograde transport, endosome to Golgi (GO:0042147)2.56910708
152response to laminar fluid shear stress (GO:0034616)2.55679528
153negative regulation of cartilage development (GO:0061037)2.52961939
154mRNA transcription (GO:0009299)2.51161252
155negative regulation of striated muscle cell apoptotic process (GO:0010664)2.48955145
156histone lysine demethylation (GO:0070076)2.48800699
157trophoblast giant cell differentiation (GO:0060707)2.48477946
158patterning of blood vessels (GO:0001569)2.46491966
159negative regulation of cell size (GO:0045792)2.45531259
160protein-DNA complex disassembly (GO:0032986)2.45270271
161nucleosome disassembly (GO:0006337)2.45270271
162cell volume homeostasis (GO:0006884)2.43187824
163embryo implantation (GO:0007566)2.42887371
164regulation of monocyte differentiation (GO:0045655)2.41992947
165hyaluronan catabolic process (GO:0030214)2.40563542
166negative regulation of fatty acid transport (GO:2000192)2.39576951
167embryonic camera-type eye development (GO:0031076)2.39302786
168radial glial cell differentiation (GO:0060019)2.39141146
169cortical cytoskeleton organization (GO:0030865)2.38965996
170protein export from nucleus (GO:0006611)2.37919039
171stress fiber assembly (GO:0043149)2.37689404
172nuclear pore organization (GO:0006999)2.37019844
173regulation of mammary gland epithelial cell proliferation (GO:0033599)2.35483880
174regulation of RNA export from nucleus (GO:0046831)2.33722569
175histone demethylation (GO:0016577)2.33426597
176protein localization to cell surface (GO:0034394)2.31310733
177organ formation (GO:0048645)2.31288584
178cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.30900678
179positive regulation of odontogenesis (GO:0042482)2.27935731
180negative regulation of myoblast differentiation (GO:0045662)2.27812205
181regulation of histone H3-K27 methylation (GO:0061085)2.27714333
182protein localization to endosome (GO:0036010)2.27398813
183regulation of early endosome to late endosome transport (GO:2000641)2.27294454
184UV protection (GO:0009650)2.26495608
185eye morphogenesis (GO:0048592)2.26137303
186response to epidermal growth factor (GO:0070849)2.25834165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.26275745
2TP63_19390658_ChIP-ChIP_HaCaT_Human3.38509727
3WT1_19549856_ChIP-ChIP_CCG9911_Human3.16485986
4* EED_16625203_ChIP-ChIP_MESCs_Mouse2.88998443
5* EZH2_27304074_Chip-Seq_ESCs_Mouse2.82738789
6MYC_22102868_ChIP-Seq_BL_Human2.78048633
7* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.73290245
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.73076372
9VDR_21846776_ChIP-Seq_THP-1_Human2.72055638
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.61197593
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.57655685
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.55829916
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.55829916
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.55829916
15* TP53_20018659_ChIP-ChIP_R1E_Mouse2.54442275
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.50022948
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.47999267
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47346459
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.46746769
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44885807
21* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44885807
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.37317522
23ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.34949545
24CLOCK_20551151_ChIP-Seq_293T_Human2.34287189
25ZFP281_18757296_ChIP-ChIP_E14_Mouse2.34092556
26* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30010541
27LXR_22292898_ChIP-Seq_THP-1_Human2.29996302
28TP63_17297297_ChIP-ChIP_HaCaT_Human2.24404784
29* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16938185
30* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15700986
31RACK7_27058665_Chip-Seq_MCF-7_Human2.14435033
32STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08774141
33* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04980158
34* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04101915
35* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.01821097
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01758266
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.96664701
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92466507
39TCF3_18692474_ChIP-Seq_MEFs_Mouse1.92152816
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89663915
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89033913
42TCF7_22412390_ChIP-Seq_EML_Mouse1.88297051
43* RING1B_27294783_Chip-Seq_NPCs_Mouse1.87986343
44* CBX2_27304074_Chip-Seq_ESCs_Mouse1.81968738
45DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81345120
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.80148398
47* RNF2_27304074_Chip-Seq_ESCs_Mouse1.78349871
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.77865172
49* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76114802
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75779495
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.74726887
52E2F7_22180533_ChIP-Seq_HELA_Human1.73353706
53ZNF263_19887448_ChIP-Seq_K562_Human1.70658396
54* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66688364
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.66374182
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65794365
57* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62775867
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62397439
59FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.59850310
60* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59792191
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58251264
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.57888625
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57542604
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56710846
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.55575790
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.55514603
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55414654
68* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.55072134
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54144433
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52618749
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51823293
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51285558
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50765816
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.50020517
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.49117951
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49029314
77MYC_18555785_ChIP-Seq_MESCs_Mouse1.44180490
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43737241
79CREB1_26743006_Chip-Seq_LNCaP_Human1.42592647
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41691707
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40655496
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40345640
83AR_21909140_ChIP-Seq_LNCAP_Human1.40242371
84ATF3_27146783_Chip-Seq_COLON_Human1.39499121
85MAF_26560356_Chip-Seq_TH2_Human1.38361303
86EZH2_22144423_ChIP-Seq_EOC_Human1.37888059
87* SA1_27219007_Chip-Seq_ERYTHROID_Human1.37512587
88SMC4_20622854_ChIP-Seq_HELA_Human1.37361338
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.36359658
90* MAF_26560356_Chip-Seq_TH1_Human1.36285745
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36064444
92NANOG_16153702_ChIP-ChIP_HESCs_Human1.35359944
93NCOR1_26117541_ChIP-Seq_K562_Human1.35273330
94VDR_24763502_ChIP-Seq_THP-1_Human1.34703602
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34563337
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32986553
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32847495
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32543137
99CDX2_20551321_ChIP-Seq_CACO-2_Human1.32116619
100UTX_26944678_Chip-Seq_JUKART_Human1.31843445
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31017751
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28365171
103MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28255012
104SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.28244308
105KDM2B_26808549_Chip-Seq_JURKAT_Human1.28101721
106E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26661839
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25312173
108* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25174056
109* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25001612
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24404533
111* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23101187
112P68_20966046_ChIP-Seq_HELA_Human1.22136450
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21883598
114ERG_21242973_ChIP-ChIP_JURKAT_Human1.21011001
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20664711
116CHD1_26751641_Chip-Seq_LNCaP_Human1.19393897
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18776569
118KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17398434
119TET1_21451524_ChIP-Seq_MESCs_Mouse1.17352995
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.15983685
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15905783
122BRD4_25478319_ChIP-Seq_HGPS_Human1.15709125
123RUNX1_27514584_Chip-Seq_MCF-7_Human1.15099423
124KDM2B_26808549_Chip-Seq_DND41_Human1.14068907
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13695907
126TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13592153
127* EZH2_27294783_Chip-Seq_ESCs_Mouse1.13396504
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12813472
129TP53_22127205_ChIP-Seq_IMR90_Human1.12552731
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11947257
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11318787
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11288109
133SOX2_16153702_ChIP-ChIP_HESCs_Human1.10914440
134CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10817081
135XRN2_22483619_ChIP-Seq_HELA_Human1.10486363
136KDM2B_26808549_Chip-Seq_K562_Human1.09762178
137ESR2_21235772_ChIP-Seq_MCF-7_Human1.09385911
138RUNX1_22412390_ChIP-Seq_EML_Mouse1.09057591
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08529400
140ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08189367
141IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07659413
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07338826
143HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05531387
144SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04967283
145ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04696223
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04082532
147DCP1A_22483619_ChIP-Seq_HELA_Human1.04002706
148BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03580140
149CTCF_21964334_Chip-Seq_Bcells_Human1.02217864
150FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02046413
151EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02043014
152TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01988137
153RXR_22108803_ChIP-Seq_LS180_Human1.00556625
154CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00161395
155GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00132918
156UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00045483
157OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99965209
158NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99342222
159RARA_24833708_ChIP-Seq_LIVER_Mouse0.98327478
160SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98321076
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98090900
162* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97853882
163NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96822501
164STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93112061
165NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92074615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.77111311
2MP0003705_abnormal_hypodermis_morpholog3.58121771
3MP0008438_abnormal_cutaneous_collagen3.51454812
4MP0009053_abnormal_anal_canal3.50735688
5MP0010030_abnormal_orbit_morphology3.27426732
6MP0003385_abnormal_body_wall3.24731117
7* MP0009250_abnormal_appendicular_skeleto3.23856522
8MP0009384_cardiac_valve_regurgitation2.97849586
9MP0005503_abnormal_tendon_morphology2.94083356
10MP0001879_abnormal_lymphatic_vessel2.93282383
11MP0000537_abnormal_urethra_morphology2.64222504
12MP0005451_abnormal_body_composition2.55704036
13MP0002249_abnormal_larynx_morphology2.51421508
14MP0000049_abnormal_middle_ear2.37798318
15MP0003123_paternal_imprinting2.37233367
16MP0005409_darkened_coat_color2.27669434
17MP0004272_abnormal_basement_membrane2.25608734
18MP0005623_abnormal_meninges_morphology2.21335948
19MP0003937_abnormal_limbs/digits/tail_de2.14588766
20MP0005076_abnormal_cell_differentiation2.01082790
21MP0002009_preneoplasia2.00557175
22MP0003122_maternal_imprinting1.97528574
23MP0003942_abnormal_urinary_system1.95653488
24MP0003279_aneurysm1.89668820
25MP0002102_abnormal_ear_morphology1.88193775
26MP0000428_abnormal_craniofacial_morphol1.84516153
27* MP0003755_abnormal_palate_morphology1.80377512
28* MP0003935_abnormal_craniofacial_develop1.77460425
29MP0005187_abnormal_penis_morphology1.75907053
30MP0003566_abnormal_cell_adhesion1.71345003
31MP0005058_abnormal_lysosome_morphology1.68974826
32MP0005508_abnormal_skeleton_morphology1.68362621
33MP0002282_abnormal_trachea_morphology1.67080077
34MP0005275_abnormal_skin_tensile1.62358891
35* MP0002233_abnormal_nose_morphology1.61675409
36MP0002932_abnormal_joint_morphology1.58139923
37* MP0000432_abnormal_head_morphology1.58044719
38* MP0002116_abnormal_craniofacial_bone1.53651375
39* MP0000163_abnormal_cartilage_morphology1.50748325
40MP0002938_white_spotting1.50333823
41MP0003938_abnormal_ear_development1.49549582
42MP0001849_ear_inflammation1.46411700
43MP0004233_abnormal_muscle_weight1.43752001
44MP0002111_abnormal_tail_morphology1.42047217
45MP0005367_renal/urinary_system_phenotyp1.41346904
46MP0000516_abnormal_urinary_system1.41346904
47MP0002177_abnormal_outer_ear1.39820670
48MP0000678_abnormal_parathyroid_gland1.39562596
49MP0003111_abnormal_nucleus_morphology1.38121803
50MP0009278_abnormal_bone_marrow1.37732026
51MP0003315_abnormal_perineum_morphology1.36571931
52MP0004808_abnormal_hematopoietic_stem1.36399618
53MP0003121_genomic_imprinting1.35926980
54* MP0002109_abnormal_limb_morphology1.34818371
55MP0002877_abnormal_melanocyte_morpholog1.34247644
56* MP0002115_abnormal_skeleton_extremities1.34131259
57MP0000751_myopathy1.33546416
58MP0000749_muscle_degeneration1.33506920
59MP0003077_abnormal_cell_cycle1.33195122
60MP0005408_hypopigmentation1.32987339
61MP0000534_abnormal_ureter_morphology1.32574613
62MP0000759_abnormal_skeletal_muscle1.30304236
63MP0000566_synostosis1.29529801
64MP0010094_abnormal_chromosome_stability1.29150849
65MP0000762_abnormal_tongue_morphology1.27627674
66MP0010352_gastrointestinal_tract_polyps1.27166354
67MP0004858_abnormal_nervous_system1.26666953
68MP0003453_abnormal_keratinocyte_physiol1.24886971
69MP0009840_abnormal_foam_cell1.24618573
70MP0000733_abnormal_muscle_development1.24460913
71MP0002269_muscular_atrophy1.24169915
72MP0003119_abnormal_digestive_system1.23442046
73MP0002086_abnormal_extraembryonic_tissu1.20629629
74MP0008004_abnormal_stomach_pH1.19270400
75MP0010234_abnormal_vibrissa_follicle1.18794623
76MP0002114_abnormal_axial_skeleton1.17786452
77MP0005023_abnormal_wound_healing1.16685228
78MP0001661_extended_life_span1.13796432
79MP0003693_abnormal_embryo_hatching1.13620753
80MP0005248_abnormal_Harderian_gland1.11801735
81MP0002084_abnormal_developmental_patter1.11545976
82MP0002085_abnormal_embryonic_tissue1.10520134
83MP0001293_anophthalmia1.10391388
84* MP0002113_abnormal_skeleton_development1.09806987
85* MP0001299_abnormal_eye_distance/1.09361507
86MP0003283_abnormal_digestive_organ1.09030014
87MP0005257_abnormal_intraocular_pressure1.08207518
88MP0000747_muscle_weakness1.07712443
89MP0010630_abnormal_cardiac_muscle1.05318600
90MP0004134_abnormal_chest_morphology1.04884721
91MP0004197_abnormal_fetal_growth/weight/1.04429148
92MP0004087_abnormal_muscle_fiber1.02010884
93MP0008932_abnormal_embryonic_tissue1.01297570
94MP0000767_abnormal_smooth_muscle1.00576415
95MP0003828_pulmonary_edema1.00381212
96MP0001958_emphysema0.99790633
97MP0002132_abnormal_respiratory_system0.99397429
98MP0002108_abnormal_muscle_morphology0.99134775
99MP0002697_abnormal_eye_size0.98230738
100MP0002080_prenatal_lethality0.97401711
101MP0003890_abnormal_embryonic-extraembry0.97003961
102MP0005621_abnormal_cell_physiology0.94485059
103MP0003941_abnormal_skin_development0.93661592
104MP0002896_abnormal_bone_mineralization0.91895531
105MP0003091_abnormal_cell_migration0.91590677
106MP0003861_abnormal_nervous_system0.91345583
107MP0003567_abnormal_fetal_cardiomyocyte0.90790147
108MP0001348_abnormal_lacrimal_gland0.89879158
109MP0004381_abnormal_hair_follicle0.89647622
110* MP0001340_abnormal_eyelid_morphology0.89449639
111MP0002092_abnormal_eye_morphology0.88537813
112MP0008007_abnormal_cellular_replicative0.88323900
113MP0008260_abnormal_autophagy0.87988253
114MP0002925_abnormal_cardiovascular_devel0.87219754
115MP0002089_abnormal_postnatal_growth/wei0.86042219
116MP0009672_abnormal_birth_weight0.85642716
117MP0005330_cardiomyopathy0.84567520
118MP0005380_embryogenesis_phenotype0.84045880
119MP0001672_abnormal_embryogenesis/_devel0.84045880
120MP0001614_abnormal_blood_vessel0.83359160
121MP0001730_embryonic_growth_arrest0.82615172
122* MP0002081_perinatal_lethality0.82301258
123MP0004185_abnormal_adipocyte_glucose0.81174015
124MP0002160_abnormal_reproductive_system0.80798732
125MP0001697_abnormal_embryo_size0.79930539
126MP0003115_abnormal_respiratory_system0.79771558
127MP0000750_abnormal_muscle_regeneration0.79469791
128MP0004264_abnormal_extraembryonic_tissu0.79075191
129MP0002098_abnormal_vibrissa_morphology0.79019746
130MP0002088_abnormal_embryonic_growth/wei0.78914335
131MP0002396_abnormal_hematopoietic_system0.78091438
132MP0009703_decreased_birth_body0.78037228
133MP0006138_congestive_heart_failure0.77331657
134MP0000462_abnormal_digestive_system0.76815579
135MP0003984_embryonic_growth_retardation0.76216928
136MP0004957_abnormal_blastocyst_morpholog0.75726963
137MP0002254_reproductive_system_inflammat0.75708292
138MP0000350_abnormal_cell_proliferation0.75218187
139MP0009697_abnormal_copulation0.74704662
140MP0002796_impaired_skin_barrier0.74590167
141MP0002128_abnormal_blood_circulation0.74458579
142MP0000003_abnormal_adipose_tissue0.74304846
143MP0001915_intracranial_hemorrhage0.73767179
144MP0002653_abnormal_ependyma_morphology0.73131943
145MP0002127_abnormal_cardiovascular_syste0.72770378
146MP0002295_abnormal_pulmonary_circulatio0.72353567

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.71485412
2Shallow orbits (HP:0000586)4.45395810
3Premature rupture of membranes (HP:0001788)4.12174494
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.79611657
5Short 4th metacarpal (HP:0010044)3.79611657
6Abnormality of the parietal bone (HP:0002696)3.69665747
7Mesomelia (HP:0003027)3.40081334
8Midline defect of the nose (HP:0004122)3.34659235
9Renal duplication (HP:0000075)3.33469040
10Spinal rigidity (HP:0003306)3.30965188
11Hyperacusis (HP:0010780)3.28580015
12Abnormality of the 4th metacarpal (HP:0010012)3.12437588
13Broad metatarsal (HP:0001783)3.11303227
14Coronal craniosynostosis (HP:0004440)3.06839943
15Short middle phalanx of the 5th finger (HP:0004220)2.96028730
16Centrally nucleated skeletal muscle fibers (HP:0003687)2.92027286
17Thoracic kyphosis (HP:0002942)2.88930989
18Concave nail (HP:0001598)2.88523402
19Abnormality of the phalanges of the 2nd finger (HP:0009541)2.87635746
20Ulnar bowing (HP:0003031)2.82818980
21Increased variability in muscle fiber diameter (HP:0003557)2.79974814
22Broad toe (HP:0001837)2.78760474
23Abnormality of the 2nd finger (HP:0004100)2.77479342
24Short 5th finger (HP:0009237)2.75966211
25Hepatoblastoma (HP:0002884)2.69042246
26Abnormality of dentin (HP:0010299)2.69009629
27Biconcave vertebral bodies (HP:0004586)2.64969031
28Soft skin (HP:0000977)2.64467822
29Abnormality of the thoracic spine (HP:0100711)2.61665977
30Cervical subluxation (HP:0003308)2.55001386
31Bladder diverticulum (HP:0000015)2.54739195
32Spinal cord lesions (HP:0100561)2.53239499
33Syringomyelia (HP:0003396)2.53239499
34Camptodactyly of toe (HP:0001836)2.52741871
35Abnormality of the phalanges of the hallux (HP:0010057)2.52721092
36Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.52700844
37Short hallux (HP:0010109)2.50666183
38Deviation of the hallux (HP:0010051)2.50616841
39Stridor (HP:0010307)2.49979043
40Nonimmune hydrops fetalis (HP:0001790)2.49761072
41Genu recurvatum (HP:0002816)2.48146925
42Selective tooth agenesis (HP:0001592)2.47178097
43Preaxial foot polydactyly (HP:0001841)2.47042147
44Partial duplication of the phalanx of hand (HP:0009999)2.45671491
45Asymmetry of the thorax (HP:0001555)2.44537016
46Ankyloglossia (HP:0010296)2.43273606
47Abnormality of skeletal muscle fiber size (HP:0012084)2.39352021
48Shawl scrotum (HP:0000049)2.34418367
49Broad thumb (HP:0011304)2.31268613
50Hallux valgus (HP:0001822)2.26867643
51Thoracolumbar scoliosis (HP:0002944)2.26425930
52Capillary hemangiomas (HP:0005306)2.25850152
53Hand muscle atrophy (HP:0009130)2.25044060
54Elbow flexion contracture (HP:0002987)2.23724986
55Turricephaly (HP:0000262)2.22704903
56Amelogenesis imperfecta (HP:0000705)2.22331457
57Buphthalmos (HP:0000557)2.20856427
58Increased connective tissue (HP:0009025)2.20149833
59Peritonitis (HP:0002586)2.19868225
60Easy fatigability (HP:0003388)2.19605741
61Dilatation of the ascending aorta (HP:0005111)2.18993307
62Aplasia/Hypoplasia of the hallux (HP:0008362)2.18290386
63Microglossia (HP:0000171)2.17409068
64Aortic dissection (HP:0002647)2.17156948
65Aortic aneurysm (HP:0004942)2.16957517
66Long eyelashes (HP:0000527)2.16833557
67Scapular winging (HP:0003691)2.16713444
68Flat cornea (HP:0007720)2.15815831
69Blue sclerae (HP:0000592)2.15554137
70Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.14083602
71Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.13236493
72Hydroureter (HP:0000072)2.13109447
73Wormian bones (HP:0002645)2.13026993
74Exercise-induced myalgia (HP:0003738)2.12297818
75Wide anterior fontanel (HP:0000260)2.10380246
76Insomnia (HP:0100785)2.08998351
77Self-mutilation (HP:0000742)2.07587281
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06330628
79Broad long bones (HP:0005622)2.05976047
80Facial hemangioma (HP:0000329)2.04238324
81Broad hallux (HP:0010055)2.02627330
82Abnormality of the phalanges of the 5th finger (HP:0004213)2.01783932
83Thin ribs (HP:0000883)2.01610167
84Neonatal short-limb short stature (HP:0008921)2.01097137
85Difficulty climbing stairs (HP:0003551)2.01019755
86Broad phalanges of the hand (HP:0009768)2.00124168
87Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.00121019
88Long palpebral fissure (HP:0000637)2.00086904
89Bulbar palsy (HP:0001283)2.00019490
90Broad phalanx (HP:0006009)1.99355828
91Long toe (HP:0010511)1.99299828
92Broad finger (HP:0001500)1.97442310
93Short nail (HP:0001799)1.97102792
94Distal upper limb amyotrophy (HP:0007149)1.96488846
95Upper limb amyotrophy (HP:0009129)1.96488846
96Atelectasis (HP:0100750)1.96433780
97Abnormality of the peritoneum (HP:0002585)1.95703916
98Mitral valve prolapse (HP:0001634)1.95064251
99Atrophic scars (HP:0001075)1.94967336
100Short middle phalanx of finger (HP:0005819)1.93286061
101Generalized amyotrophy (HP:0003700)1.92576130
102Vertebral compression fractures (HP:0002953)1.92076070
103Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.91659944
104Exostoses (HP:0100777)1.91428870
105Vascular tortuosity (HP:0004948)1.90791004
106Abnormality of the fetal cardiovascular system (HP:0010948)1.89488838
107Abnormal umbilical cord blood vessels (HP:0011403)1.89488838
108Single umbilical artery (HP:0001195)1.89488838
109Abnormality of the lumbar spine (HP:0100712)1.89421155
110Bowing of the arm (HP:0006488)1.87135810
111Bowed forearm bones (HP:0003956)1.87135810
112Supernumerary ribs (HP:0005815)1.86834709
113Aplasia cutis congenita (HP:0001057)1.85365878
114Thin bony cortex (HP:0002753)1.85204594
115Pseudobulbar signs (HP:0002200)1.84835262
116Joint contractures involving the joints of the feet (HP:0100492)1.84693467
117Flexion contracture of toe (HP:0005830)1.84693467
118Bowel diverticulosis (HP:0005222)1.84200290
119Resting tremor (HP:0002322)1.82872233
120Abnormality of the distal phalanx of the thumb (HP:0009617)1.81476406
121Delayed cranial suture closure (HP:0000270)1.81349294
122Nuclear cataract (HP:0100018)1.81335879
123Abnormal ossification of hand bones (HP:0005921)1.81179580
124Achilles tendon contracture (HP:0001771)1.79920310
125Abnormality of oral frenula (HP:0000190)1.79346861
126Broad face (HP:0000283)1.78608596
127Arterial tortuosity (HP:0005116)1.78335416
128Abnormality of the middle phalanges of the toes (HP:0010183)1.77141378
129Hypercalcemia (HP:0003072)1.76902299
130Congenital glaucoma (HP:0001087)1.75619381
131Disproportionate tall stature (HP:0001519)1.75283960
132Dislocated radial head (HP:0003083)1.75261311
133Myopathic facies (HP:0002058)1.75201888
134Abnormality of the calcaneus (HP:0008364)1.75012517
135Absent eyebrow (HP:0002223)1.74996218
136Broad distal phalanx of finger (HP:0009836)1.74763060
137Trigonocephaly (HP:0000243)1.74154307
138Patellar dislocation (HP:0002999)1.74139396
139Protruding ear (HP:0000411)1.73720561
140Cerebral aneurysm (HP:0004944)1.73349785
141Joint laxity (HP:0001388)1.73232710
142Deviation of the thumb (HP:0009603)1.72900950
143Bifid tongue (HP:0010297)1.71864731
144Abnormality of the radial head (HP:0003995)1.71556415
145Tongue fasciculations (HP:0001308)1.71094475
146Broad ribs (HP:0000885)1.71052220
147Hyporeflexia of lower limbs (HP:0002600)1.70249209
148Proximal placement of thumb (HP:0009623)1.70142705
149Reduced antithrombin III activity (HP:0001976)1.69619827
150Ankle contracture (HP:0006466)1.68887887
151Sparse lateral eyebrow (HP:0005338)1.68155309
152Aneurysm (HP:0002617)1.64474078
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.63713393
154Osteolytic defects of the hand bones (HP:0009699)1.63713393
155Hypoplasia of the iris (HP:0007676)1.63685169
156Type 1 muscle fiber predominance (HP:0003803)1.60876862
157Natal tooth (HP:0000695)1.58689749
158Reticulocytosis (HP:0001923)1.57653053
159Vertebral arch anomaly (HP:0008438)1.57629842
160Ectopia lentis (HP:0001083)1.54885204
161Fragile skin (HP:0001030)1.53490837
162Colitis (HP:0002583)1.53190981
163Flattened epiphyses (HP:0003071)1.52973904
164Overriding aorta (HP:0002623)1.52950132
165Elfin facies (HP:0004428)1.52795299
166Weak cry (HP:0001612)1.52514338
167Bowel incontinence (HP:0002607)1.49901245
168Abnormality of the Achilles tendon (HP:0005109)1.49150141
169Renovascular hypertension (HP:0100817)1.49129525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS25.50987061
2LATS14.14434344
3EPHB23.74486643
4PDGFRA3.27767604
5DDR23.21236916
6EEF2K2.91882788
7TIE12.66924107
8PRPF4B2.60238100
9SMG12.57113974
10MKNK12.46475695
11MAP3K102.45577052
12CAMK1G2.40266827
13PINK12.40064868
14NME22.20391970
15NTRK32.20084110
16KSR22.15580297
17MARK32.15127446
18CAMK1D2.10086219
19RIPK12.01405990
20CDK122.00382590
21TRIB31.89133981
22MAPK151.77817333
23CAMKK21.76157032
24PAK41.72575281
25STK38L1.71328282
26MAP3K21.66282275
27PAK21.65835058
28KSR11.59196075
29ERBB31.54256173
30SIK11.40020951
31DYRK31.35507819
32BRD41.33425171
33IRAK31.32995403
34NEK91.31986299
35MELK1.31773737
36FGFR41.29945565
37MAP2K31.24416968
38RPS6KA41.24148656
39MKNK21.22622865
40SRPK11.22063783
41PASK1.17552907
42IRAK21.15904275
43CDC71.15494749
44MAP3K11.14961954
45CAMK41.11065642
46TGFBR11.10303336
47MST1R1.10266631
48PKN21.10217990
49MYLK1.07711914
50RAF11.07217791
51MAP3K81.05099723
52PTK21.04852626
53TLK11.04269879
54CDK61.00618881
55CAMKK11.00531190
56WNK11.00368021
57MAP3K130.99388087
58FGR0.98993848
59FGFR10.98842619
60PNCK0.97153711
61LIMK10.94799300
62TTN0.92949436
63PAK30.91236121
64TGFBR20.89932445
65PRKD20.89056355
66MTOR0.87396274
67BMX0.87250290
68GRK10.86067723
69EPHA20.85855523
70RPS6KA20.79858687
71UHMK10.78052299
72CDK30.77873649
73TTK0.77649733
74SGK2230.76534261
75SGK4940.76534261
76BLK0.75503730
77RPS6KL10.74759889
78RPS6KC10.74759889
79PDGFRB0.74256562
80MAP3K30.74038027
81TAOK20.73231721
82EPHB10.71351800
83PTK60.70164739
84ILK0.70124933
85SGK30.69152944
86TESK10.68055059
87ROCK20.67273469
88TAOK10.67233829
89CSNK1E0.66972353
90ZAP700.66437723
91MARK20.66410777
92ERN10.66037511
93TRPM70.65228469
94DYRK1B0.64921249
95FGFR20.63767466
96PDPK10.63581206
97CDK70.63542893
98ERBB20.62812563
99PLK20.61951294
100MAPK110.61884364
101MAP3K70.61545653
102STK380.61004311
103MAPK120.60905628
104STK30.60257515
105TYRO30.58562419
106FER0.58227576
107WEE10.57571885
108CDK140.57393162
109CDK40.55899298
110PAK10.55114743
111PBK0.54272613
112ALK0.53070886
113ADRBK10.53031876
114IRAK40.52989509
115IGF1R0.52575251
116MET0.52331514
117DAPK30.51953049
118MAP2K10.51663083
119NEK20.51473564
120MAP2K70.50409479
121AKT30.49009648
122PLK30.48756451
123NLK0.48140373
124FGFR30.47452621
125KIT0.47360755
126INSR0.46500088
127NTRK10.46307741
128RPS6KB10.46108664
129ABL20.45466106
130RPS6KA60.44789510
131SRC0.44065324
132ROCK10.44053576
133PIM20.42526831
134ICK0.42326179
135HIPK20.41351596
136CDK150.41259242
137SGK20.41146153
138CDK11A0.40852030
139TSSK60.40404795
140RPS6KB20.39937089
141MOS0.39827228
142STK100.39463622
143AKT20.39256400
144CSNK1A1L0.38476460
145RET0.38031803
146CDK80.36148122
147RPS6KA10.36061773
148CDC42BPA0.35518278
149MAP3K60.35506230
150CDK180.35335281
151PRKG20.34522312
152KDR0.33893471
153ARAF0.32297448
154CLK10.32084395
155LRRK20.32026262
156BRAF0.31834160
157PRKD30.31674867
158STK390.29907352
159BTK0.29548494

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.93783685
2Hedgehog signaling pathway_Homo sapiens_hsa043403.20702097
3Hippo signaling pathway_Homo sapiens_hsa043902.57752412
4Focal adhesion_Homo sapiens_hsa045102.48273736
5ECM-receptor interaction_Homo sapiens_hsa045122.29343593
6Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.12674284
7Proteoglycans in cancer_Homo sapiens_hsa052052.10452393
8Wnt signaling pathway_Homo sapiens_hsa043102.06780523
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.05052313
10MicroRNAs in cancer_Homo sapiens_hsa052062.04539693
11Spliceosome_Homo sapiens_hsa030402.03788414
12TGF-beta signaling pathway_Homo sapiens_hsa043501.98456395
13Melanoma_Homo sapiens_hsa052181.88369494
14Axon guidance_Homo sapiens_hsa043601.88156977
15Adherens junction_Homo sapiens_hsa045201.85397065
16Ribosome_Homo sapiens_hsa030101.81500898
17Acute myeloid leukemia_Homo sapiens_hsa052211.81295736
18PI3K-Akt signaling pathway_Homo sapiens_hsa041511.76759321
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.75441735
20Notch signaling pathway_Homo sapiens_hsa043301.72614468
21Rap1 signaling pathway_Homo sapiens_hsa040151.72214300
22Pathways in cancer_Homo sapiens_hsa052001.70704580
23Thyroid cancer_Homo sapiens_hsa052161.70386663
24Melanogenesis_Homo sapiens_hsa049161.70201950
25Bladder cancer_Homo sapiens_hsa052191.69753400
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.67692866
27Prostate cancer_Homo sapiens_hsa052151.65759750
28Other glycan degradation_Homo sapiens_hsa005111.57265251
29Gap junction_Homo sapiens_hsa045401.51688861
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50771425
31Cell cycle_Homo sapiens_hsa041101.47543462
32Ras signaling pathway_Homo sapiens_hsa040141.43601533
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.37765343
34Chronic myeloid leukemia_Homo sapiens_hsa052201.37594034
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34929991
36DNA replication_Homo sapiens_hsa030301.34860920
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.33732177
38Renal cell carcinoma_Homo sapiens_hsa052111.31639259
39Glioma_Homo sapiens_hsa052141.31519406
40Apoptosis_Homo sapiens_hsa042101.30808202
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28423460
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.22918700
43Hepatitis B_Homo sapiens_hsa051611.19321465
44Small cell lung cancer_Homo sapiens_hsa052221.17007724
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16119346
46RNA transport_Homo sapiens_hsa030131.12730681
47Insulin signaling pathway_Homo sapiens_hsa049101.11827526
48Colorectal cancer_Homo sapiens_hsa052101.09646523
49B cell receptor signaling pathway_Homo sapiens_hsa046621.09564348
50Tight junction_Homo sapiens_hsa045301.06947900
51HTLV-I infection_Homo sapiens_hsa051661.06257234
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.05990916
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00742824
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99684806
55Dilated cardiomyopathy_Homo sapiens_hsa054140.97233837
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.96502335
57AMPK signaling pathway_Homo sapiens_hsa041520.95490184
58mTOR signaling pathway_Homo sapiens_hsa041500.95080270
59Circadian entrainment_Homo sapiens_hsa047130.94394166
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92628071
61Lysine degradation_Homo sapiens_hsa003100.91661975
62Choline metabolism in cancer_Homo sapiens_hsa052310.87658845
63FoxO signaling pathway_Homo sapiens_hsa040680.84971925
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84068664
65mRNA surveillance pathway_Homo sapiens_hsa030150.82711315
66Long-term depression_Homo sapiens_hsa047300.82663885
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82023926
68HIF-1 signaling pathway_Homo sapiens_hsa040660.81770043
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81231658
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81076028
71Dorso-ventral axis formation_Homo sapiens_hsa043200.81065103
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.79440236
73Oocyte meiosis_Homo sapiens_hsa041140.77845464
74Cholinergic synapse_Homo sapiens_hsa047250.77205876
75N-Glycan biosynthesis_Homo sapiens_hsa005100.76955747
76Pentose phosphate pathway_Homo sapiens_hsa000300.75953741
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74492344
78Sulfur relay system_Homo sapiens_hsa041220.74043498
79Protein digestion and absorption_Homo sapiens_hsa049740.73543609
80T cell receptor signaling pathway_Homo sapiens_hsa046600.72778458
81Shigellosis_Homo sapiens_hsa051310.72685147
82Glutamatergic synapse_Homo sapiens_hsa047240.72630780
83GnRH signaling pathway_Homo sapiens_hsa049120.72604373
84Fructose and mannose metabolism_Homo sapiens_hsa000510.71956738
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69717067
86Osteoclast differentiation_Homo sapiens_hsa043800.68837951
87Inositol phosphate metabolism_Homo sapiens_hsa005620.68616246
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68132884
89Alcoholism_Homo sapiens_hsa050340.67768856
90Biosynthesis of amino acids_Homo sapiens_hsa012300.66013559
91Measles_Homo sapiens_hsa051620.65287882
92Endometrial cancer_Homo sapiens_hsa052130.65207108
93Prolactin signaling pathway_Homo sapiens_hsa049170.65178896
94Hepatitis C_Homo sapiens_hsa051600.64663565
95Glucagon signaling pathway_Homo sapiens_hsa049220.64496243
96TNF signaling pathway_Homo sapiens_hsa046680.64418158
97Nitrogen metabolism_Homo sapiens_hsa009100.62311994
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62233416
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61399407
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60884707
101Toxoplasmosis_Homo sapiens_hsa051450.60467227
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60160066
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59915774
104Amoebiasis_Homo sapiens_hsa051460.59833680
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59782908
106Herpes simplex infection_Homo sapiens_hsa051680.58994980
107VEGF signaling pathway_Homo sapiens_hsa043700.58994514
108ErbB signaling pathway_Homo sapiens_hsa040120.57366255
109Endocytosis_Homo sapiens_hsa041440.57351018
110Influenza A_Homo sapiens_hsa051640.56884908
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.55768465
112Dopaminergic synapse_Homo sapiens_hsa047280.54831962
113GABAergic synapse_Homo sapiens_hsa047270.54712776
114MAPK signaling pathway_Homo sapiens_hsa040100.54306011
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.53214549
116Platelet activation_Homo sapiens_hsa046110.51958274
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51593599
118Non-small cell lung cancer_Homo sapiens_hsa052230.50796457
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50391197
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50140510
121Estrogen signaling pathway_Homo sapiens_hsa049150.49521630
122Pancreatic cancer_Homo sapiens_hsa052120.48340183
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47702022
124Glutathione metabolism_Homo sapiens_hsa004800.47286388
125Viral myocarditis_Homo sapiens_hsa054160.47236963
126Viral carcinogenesis_Homo sapiens_hsa052030.45559286
127Prion diseases_Homo sapiens_hsa050200.45483001
128Cocaine addiction_Homo sapiens_hsa050300.44532957
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44523298
130p53 signaling pathway_Homo sapiens_hsa041150.44360132
131Malaria_Homo sapiens_hsa051440.43637730
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42556765
133Proteasome_Homo sapiens_hsa030500.41286545
134Oxytocin signaling pathway_Homo sapiens_hsa049210.39818664
135Serotonergic synapse_Homo sapiens_hsa047260.38278136
136RNA degradation_Homo sapiens_hsa030180.33027915
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.32771913

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »