ALX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)8.04820545
2regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.92358364
3mesenchymal-epithelial cell signaling (GO:0060638)6.81727933
4bone trabecula formation (GO:0060346)5.79137933
5craniofacial suture morphogenesis (GO:0097094)5.68537781
6collagen fibril organization (GO:0030199)5.49053651
7regulation of non-canonical Wnt signaling pathway (GO:2000050)5.41972988
8regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.39372926
9cell proliferation involved in metanephros development (GO:0072203)5.32028440
10cell proliferation involved in kidney development (GO:0072111)5.09511627
11skeletal muscle organ development (GO:0060538)5.02512482
12mesenchymal cell proliferation (GO:0010463)4.95755420
13prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.95600241
14regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.69940638
15planar cell polarity pathway involved in neural tube closure (GO:0090179)4.68909747
16radial glial cell differentiation (GO:0060019)4.65283728
17embryonic camera-type eye development (GO:0031076)4.62516435
18cranial suture morphogenesis (GO:0060363)4.59902111
19sequestering of extracellular ligand from receptor (GO:0035581)4.50939922
20mesenchymal cell differentiation (GO:0048762)4.44528771
21regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.40795333
22collagen catabolic process (GO:0030574)4.25835893
23glomerular basement membrane development (GO:0032836)4.20128810
24negative regulation of DNA repair (GO:0045738)4.13151598
25limb bud formation (GO:0060174)4.12602041
26middle ear morphogenesis (GO:0042474)4.08341070
27mesonephros development (GO:0001823)4.06744399
28collagen metabolic process (GO:0032963)4.06178786
29embryonic skeletal joint morphogenesis (GO:0060272)4.01975821
30somite development (GO:0061053)4.00070583
31eyelid development in camera-type eye (GO:0061029)3.98249287
32otic vesicle formation (GO:0030916)3.96897702
33convergent extension (GO:0060026)3.95638078
34embryonic body morphogenesis (GO:0010172)3.94795750
35negative regulation of osteoblast proliferation (GO:0033689)3.94333316
36regulation of keratinocyte proliferation (GO:0010837)3.93310273
37head development (GO:0060322)3.92293064
38hippo signaling (GO:0035329)3.89579342
39multicellular organismal catabolic process (GO:0044243)3.86833143
40camera-type eye morphogenesis (GO:0048593)3.83565634
41multicellular organismal macromolecule metabolic process (GO:0044259)3.82919667
42negative regulation of catenin import into nucleus (GO:0035414)3.78291706
43cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.77801679
44mesenchymal cell differentiation involved in kidney development (GO:0072161)3.74164727
45mesenchymal cell differentiation involved in renal system development (GO:2001012)3.74164727
46eye morphogenesis (GO:0048592)3.71959335
47branching involved in salivary gland morphogenesis (GO:0060445)3.70390638
48heart morphogenesis (GO:0003007)3.69086570
49G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.68677771
50branching involved in labyrinthine layer morphogenesis (GO:0060670)3.68065285
51muscle cell fate commitment (GO:0042693)3.66639859
52regulation of heart morphogenesis (GO:2000826)3.65299490
53embryonic cranial skeleton morphogenesis (GO:0048701)3.63871850
54body morphogenesis (GO:0010171)3.63126987
55multicellular organismal metabolic process (GO:0044236)3.60008606
56branching involved in prostate gland morphogenesis (GO:0060442)3.57065164
57dorsal/ventral neural tube patterning (GO:0021904)3.56162567
58* embryonic skeletal system morphogenesis (GO:0048704)3.55805204
59negative regulation of chondrocyte differentiation (GO:0032331)3.48586259
60digestive tract morphogenesis (GO:0048546)3.47746888
61extracellular regulation of signal transduction (GO:1900115)3.46202115
62extracellular negative regulation of signal transduction (GO:1900116)3.46202115
63cell differentiation involved in kidney development (GO:0061005)3.43670453
64regulation of smoothened signaling pathway (GO:0008589)3.42820010
65branch elongation of an epithelium (GO:0060602)3.42433168
66keratinocyte proliferation (GO:0043616)3.42414584
67negative regulation of stem cell proliferation (GO:2000647)3.41390818
68notochord development (GO:0030903)3.40304728
69artery smooth muscle contraction (GO:0014824)3.38371848
70cochlea morphogenesis (GO:0090103)3.36626777
71epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.36246847
72endocardial cushion morphogenesis (GO:0003203)3.34448470
73respiratory system process (GO:0003016)3.33813520
74outer ear morphogenesis (GO:0042473)3.33206292
75diaphragm development (GO:0060539)3.30463603
76* embryonic appendage morphogenesis (GO:0035113)3.28457350
77* embryonic limb morphogenesis (GO:0030326)3.28457350
78Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.27536316
79dosage compensation (GO:0007549)3.25626954
80* hindlimb morphogenesis (GO:0035137)3.25592077
81trophoblast giant cell differentiation (GO:0060707)3.23646194
82proximal/distal pattern formation (GO:0009954)3.22960223
83* forelimb morphogenesis (GO:0035136)3.21880346
84cartilage morphogenesis (GO:0060536)3.20962455
85axis elongation (GO:0003401)3.19807479
86mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.18965347
87regulation of establishment of planar polarity (GO:0090175)3.16569865
88* embryonic organ morphogenesis (GO:0048562)3.15490397
89negative regulation of smoothened signaling pathway (GO:0045879)3.14807880
90organ growth (GO:0035265)3.14492090
91prostate gland epithelium morphogenesis (GO:0060740)3.14393717
92genitalia morphogenesis (GO:0035112)3.14179945
93kidney morphogenesis (GO:0060993)3.13494316
94* skeletal system morphogenesis (GO:0048705)3.10253471
95axon extension involved in axon guidance (GO:0048846)3.10227665
96neuron projection extension involved in neuron projection guidance (GO:1902284)3.10227665
97embryonic digestive tract morphogenesis (GO:0048557)3.09743026
98positive regulation of smoothened signaling pathway (GO:0045880)3.09160207
99regulation of pigment cell differentiation (GO:0050932)3.09028206
100* appendage morphogenesis (GO:0035107)3.06455872
101* limb morphogenesis (GO:0035108)3.06455872
102regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.01235106
103pharyngeal system development (GO:0060037)2.98783532
104regulation of morphogenesis of a branching structure (GO:0060688)2.98060255
105response to pheromone (GO:0019236)2.97841166
106tonic smooth muscle contraction (GO:0014820)2.96196985
107positive regulation of transcription regulatory region DNA binding (GO:2000679)2.94834480
108negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.93597613
109mesenchyme morphogenesis (GO:0072132)2.92616070
110negative chemotaxis (GO:0050919)2.92552794
111cardiac muscle cell proliferation (GO:0060038)2.92450566
112cellular response to cholesterol (GO:0071397)2.91909099
113* embryonic forelimb morphogenesis (GO:0035115)2.91203395
114cell migration involved in heart development (GO:0060973)2.90932881
115peripheral nervous system neuron development (GO:0048935)2.90027571
116hair follicle morphogenesis (GO:0031069)2.90004724
117lung epithelium development (GO:0060428)2.89940373
118* embryonic hindlimb morphogenesis (GO:0035116)2.89199097
119cell aggregation (GO:0098743)2.89036135
120cartilage condensation (GO:0001502)2.89036135
121regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88911155
122protein heterotrimerization (GO:0070208)2.88691829
123glial cell migration (GO:0008347)2.88335186
124DNA replication checkpoint (GO:0000076)2.88097499
125metanephric mesenchyme development (GO:0072075)2.86520329
126paraxial mesoderm development (GO:0048339)2.86100665
127organ induction (GO:0001759)2.85697833
128lymph vessel development (GO:0001945)2.85611402
129lung-associated mesenchyme development (GO:0060484)2.85200579
130regulation of mesenchymal cell proliferation (GO:0010464)2.84179318
131chondrocyte differentiation (GO:0002062)2.82525278
132neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.81462994
133extracellular matrix disassembly (GO:0022617)2.81407813
134muscle cell proliferation (GO:0033002)2.80361406
135somatic stem cell division (GO:0048103)2.79993779
136negative regulation of keratinocyte proliferation (GO:0010839)2.79773367
137establishment of mitotic spindle localization (GO:0040001)2.79050816
138negative regulation of axon extension involved in axon guidance (GO:0048843)2.78720702
139non-canonical Wnt signaling pathway (GO:0035567)2.78473027
140negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.78177071
141negative regulation of cartilage development (GO:0061037)2.74991376
142positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.74598776
143chondrocyte development (GO:0002063)2.74395719
144kidney mesenchyme development (GO:0072074)2.73937426
145regulation of chondrocyte differentiation (GO:0032330)2.72588176
146embryonic skeletal system development (GO:0048706)2.72354098
147dermatan sulfate biosynthetic process (GO:0030208)2.72264673
148positive regulation of mesenchymal cell proliferation (GO:0002053)2.72213169
149dorsal/ventral axis specification (GO:0009950)2.71838696
150negative regulation of embryonic development (GO:0045992)2.71403238
151establishment of tissue polarity (GO:0007164)2.70456467
152establishment of planar polarity (GO:0001736)2.70456467
153bone morphogenesis (GO:0060349)2.69800556
154specification of organ identity (GO:0010092)2.69220087
155osteoblast development (GO:0002076)2.68786566
156cell surface receptor signaling pathway involved in heart development (GO:0061311)2.68703619
157striated muscle cell proliferation (GO:0014855)2.66139360
158myoblast migration (GO:0051451)2.65447837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.44868129
2E2F7_22180533_ChIP-Seq_HELA_Human4.21126634
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.19202835
4GBX2_23144817_ChIP-Seq_PC3_Human3.57503321
5EZH2_22144423_ChIP-Seq_EOC_Human3.46472243
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.28731273
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.24501081
8* EED_16625203_ChIP-ChIP_MESCs_Mouse2.96365515
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.90495858
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.60083624
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59410937
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57658853
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.49468831
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35748991
15* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32556533
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30183818
17* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29866425
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29569846
19* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29314576
20* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29314576
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.27870222
22* TP63_19390658_ChIP-ChIP_HaCaT_Human2.25502772
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.23745075
24* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.22547286
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22029436
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.20581783
27* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19008510
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15698947
29* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11801283
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10863553
31* CBX2_27304074_Chip-Seq_ESCs_Mouse2.08965524
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07372525
33* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06193405
34ERG_21242973_ChIP-ChIP_JURKAT_Human2.05412603
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.00937468
36* RNF2_27304074_Chip-Seq_ESCs_Mouse1.99533933
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95923378
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.94960188
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94100474
40P300_19829295_ChIP-Seq_ESCs_Human1.88214164
41* LXR_22292898_ChIP-Seq_THP-1_Human1.82661063
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77785944
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75924452
44* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.74336535
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.73455077
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72416194
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72347197
48* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71786384
49* KDM2B_26808549_Chip-Seq_K562_Human1.69495594
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68822532
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68750924
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68062502
53FUS_26573619_Chip-Seq_HEK293_Human1.66103365
54SMAD4_21799915_ChIP-Seq_A2780_Human1.62849497
55TAF15_26573619_Chip-Seq_HEK293_Human1.60833999
56* EZH2_27294783_Chip-Seq_ESCs_Mouse1.59608930
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58292687
58* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58277775
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.56953032
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55100030
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55100030
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55100030
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54534188
64* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54424679
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51881042
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51783084
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49289536
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.48888727
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48103733
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48103733
71MYC_18555785_ChIP-Seq_MESCs_Mouse1.47582083
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46924648
73XRN2_22483619_ChIP-Seq_HELA_Human1.46452104
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45356933
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.45294536
76* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44413221
77TP53_18474530_ChIP-ChIP_U2OS_Human1.44282398
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43572142
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43317156
80* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42957986
81VDR_22108803_ChIP-Seq_LS180_Human1.40868381
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40802367
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40101989
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.38844367
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38549122
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38150206
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.38079896
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36250355
89* AR_21572438_ChIP-Seq_LNCaP_Human1.36156889
90* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35025029
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32764377
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32712468
93STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.31533156
94ER_23166858_ChIP-Seq_MCF-7_Human1.31532516
95EWS_26573619_Chip-Seq_HEK293_Human1.31220171
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.31056553
97* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30090171
98MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.29858207
99IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29817221
100MYC_22102868_ChIP-Seq_BL_Human1.29377129
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.29143922
102* NANOG_18555785_Chip-Seq_ESCs_Mouse1.28520315
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28329843
104MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28199946
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27961818
106CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27956555
107KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26700090
108* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26474723
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26333703
110AHR_22903824_ChIP-Seq_MCF-7_Human1.25977908
111* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25901250
112* RNF2_27304074_Chip-Seq_NSC_Mouse1.25769518
113* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24746692
114STAT3_23295773_ChIP-Seq_U87_Human1.23874835
115* RING1B_27294783_Chip-Seq_NPCs_Mouse1.22916903
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22650240
117P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22495458
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21849604
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20984544
120SMC1_22415368_ChIP-Seq_MEFs_Mouse1.20976244
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20572999
122SMC3_22415368_ChIP-Seq_MEFs_Mouse1.20309855
123* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20160906
124KDM2B_26808549_Chip-Seq_DND41_Human1.19904905
125* TP53_20018659_ChIP-ChIP_R1E_Mouse1.19461155
126FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17924061
127SA1_22415368_ChIP-Seq_MEFs_Mouse1.17738866
128ISL1_27105846_Chip-Seq_CPCs_Mouse1.17545198
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17424171
130SA1_27219007_Chip-Seq_ERYTHROID_Human1.16987548
131RUNX2_22187159_ChIP-Seq_PCA_Human1.16041394
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15809438
133SALL1_21062744_ChIP-ChIP_HESCs_Human1.15752347
134TRIM28_21343339_ChIP-Seq_HEK293_Human1.15694400
135* VDR_21846776_ChIP-Seq_THP-1_Human1.15391059
136SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14476150
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14283005
138E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14057742
139IGF1R_20145208_ChIP-Seq_DFB_Human1.13845861
140* DROSHA_22980978_ChIP-Seq_HELA_Human1.13721467
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13580320
142CTCF_27219007_Chip-Seq_Bcells_Human1.12813389
143* RING1B_27294783_Chip-Seq_ESCs_Mouse1.12612610
144TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11531072
145* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11435570
146TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11110896
147E2F1_21310950_ChIP-Seq_MCF-7_Human1.11083690
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10787202
149* E2F1_18555785_Chip-Seq_ESCs_Mouse1.10738116
150PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10133863
151SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07997207
152RACK7_27058665_Chip-Seq_MCF-7_Human1.07514131
153POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06596537
154YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06589979
155CREB1_26743006_Chip-Seq_LNCaP_Human1.06325380
156THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05389861
157CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04800838
158* TCF4_23295773_ChIP-Seq_U87_Human1.04598926
159AR_25329375_ChIP-Seq_VCAP_Human1.03901870
160TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03772548
161CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03082104
162RXR_22108803_ChIP-Seq_LS180_Human1.02656563
163EP300_21415370_ChIP-Seq_HL-1_Mouse1.02502274
164TP53_16413492_ChIP-PET_HCT116_Human1.00750573
165ZNF263_19887448_ChIP-Seq_K562_Human1.00749412
166BCAT_22108803_ChIP-Seq_LS180_Human1.00743420
167SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00525552
168MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99586597
169KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98689110

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.51076065
2MP0002938_white_spotting4.18830497
3MP0005503_abnormal_tendon_morphology4.11843117
4* MP0009250_abnormal_appendicular_skeleto3.08146214
5MP0010030_abnormal_orbit_morphology3.03526241
6MP0003705_abnormal_hypodermis_morpholog2.93248126
7MP0005257_abnormal_intraocular_pressure2.89903584
8MP0005248_abnormal_Harderian_gland2.79567128
9MP0001299_abnormal_eye_distance/2.65185601
10MP0002102_abnormal_ear_morphology2.54964018
11MP0005187_abnormal_penis_morphology2.54561808
12MP0005377_hearing/vestibular/ear_phenot2.34761753
13MP0003878_abnormal_ear_physiology2.34761753
14* MP0003385_abnormal_body_wall2.30236503
15MP0001293_anophthalmia2.20692008
16MP0000049_abnormal_middle_ear2.20335387
17MP0002282_abnormal_trachea_morphology2.13801796
18MP0002249_abnormal_larynx_morphology2.12299557
19MP0004272_abnormal_basement_membrane2.09984992
20MP0000428_abnormal_craniofacial_morphol2.07316076
21MP0005171_absent_coat_pigmentation2.07118470
22MP0000537_abnormal_urethra_morphology2.04398204
23MP0003942_abnormal_urinary_system2.02555799
24MP0003938_abnormal_ear_development2.01555078
25MP0003122_maternal_imprinting2.00554094
26MP0004134_abnormal_chest_morphology1.98017824
27MP0003937_abnormal_limbs/digits/tail_de1.95837532
28MP0003755_abnormal_palate_morphology1.95443540
29MP0006292_abnormal_olfactory_placode1.86060584
30* MP0002116_abnormal_craniofacial_bone1.85370689
31MP0000762_abnormal_tongue_morphology1.83699946
32MP0005367_renal/urinary_system_phenotyp1.82300006
33MP0000516_abnormal_urinary_system1.82300006
34MP0002233_abnormal_nose_morphology1.80672412
35MP0005508_abnormal_skeleton_morphology1.78414220
36MP0003935_abnormal_craniofacial_develop1.78231945
37MP0008438_abnormal_cutaneous_collagen1.73957967
38MP0003136_yellow_coat_color1.70441351
39MP0002108_abnormal_muscle_morphology1.69704467
40MP0000579_abnormal_nail_morphology1.68706377
41MP0003941_abnormal_skin_development1.66991605
42MP0004858_abnormal_nervous_system1.66514745
43MP0002932_abnormal_joint_morphology1.64158301
44MP0001346_abnormal_lacrimal_gland1.61046827
45MP0009053_abnormal_anal_canal1.59819178
46* MP0002109_abnormal_limb_morphology1.51523035
47MP0000163_abnormal_cartilage_morphology1.51254803
48MP0002060_abnormal_skin_morphology1.45533872
49MP0000462_abnormal_digestive_system1.45250573
50MP0002177_abnormal_outer_ear1.44852096
51MP0000534_abnormal_ureter_morphology1.44766009
52MP0001661_extended_life_span1.44679587
53* MP0000432_abnormal_head_morphology1.42396443
54MP0002115_abnormal_skeleton_extremities1.41294525
55MP0001348_abnormal_lacrimal_gland1.36177825
56MP0003787_abnormal_imprinting1.30606250
57MP0001188_hyperpigmentation1.26315382
58MP0009780_abnormal_chondrocyte_physiolo1.23980552
59MP0003121_genomic_imprinting1.23479398
60MP0006276_abnormal_autonomic_nervous1.20404146
61MP0000427_abnormal_hair_cycle1.19432947
62MP0001849_ear_inflammation1.18990323
63MP0003111_abnormal_nucleus_morphology1.17692943
64MP0005275_abnormal_skin_tensile1.16555227
65MP0001340_abnormal_eyelid_morphology1.15887556
66MP0002114_abnormal_axial_skeleton1.13858756
67MP0005409_darkened_coat_color1.13598339
68MP0002896_abnormal_bone_mineralization1.13318425
69MP0000631_abnormal_neuroendocrine_gland1.12462786
70MP0002098_abnormal_vibrissa_morphology1.11872667
71MP0002113_abnormal_skeleton_development1.11280238
72MP0000647_abnormal_sebaceous_gland1.10169926
73MP0000778_abnormal_nervous_system1.06791198
74MP0004885_abnormal_endolymph1.06615331
75MP0005075_abnormal_melanosome_morpholog1.04015866
76MP0003119_abnormal_digestive_system1.01630578
77MP0002085_abnormal_embryonic_tissue0.99063820
78MP0002277_abnormal_respiratory_mucosa0.95788809
79MP0001177_atelectasis0.95762754
80MP0002009_preneoplasia0.95189874
81MP0000613_abnormal_salivary_gland0.94623996
82MP0002092_abnormal_eye_morphology0.93623744
83MP0001958_emphysema0.91753132
84MP0002111_abnormal_tail_morphology0.88697420
85MP0005076_abnormal_cell_differentiation0.88636105
86MP0003115_abnormal_respiratory_system0.87739619
87MP0000026_abnormal_inner_ear0.87650459
88MP0005645_abnormal_hypothalamus_physiol0.87625483
89MP0004381_abnormal_hair_follicle0.87301935
90MP0009278_abnormal_bone_marrow0.85858695
91MP0010368_abnormal_lymphatic_system0.84668689
92MP0005646_abnormal_pituitary_gland0.84083704
93MP0000759_abnormal_skeletal_muscle0.83896239
94MP0000383_abnormal_hair_follicle0.82574521
95MP0008789_abnormal_olfactory_epithelium0.81749926
96MP0002084_abnormal_developmental_patter0.81731866
97MP0005390_skeleton_phenotype0.81163053
98* MP0002081_perinatal_lethality0.80680311
99MP0001486_abnormal_startle_reflex0.80156339
100MP0000733_abnormal_muscle_development0.80125890
101MP0001286_abnormal_eye_development0.80105663
102MP0002184_abnormal_innervation0.79806565
103MP0009703_decreased_birth_body0.78167689
104MP0005193_abnormal_anterior_eye0.77953618
105MP0001984_abnormal_olfaction0.77795019
106MP0002751_abnormal_autonomic_nervous0.77380991
107MP0000372_irregular_coat_pigmentation0.77308331
108MP0005623_abnormal_meninges_morphology0.77179642
109MP0002132_abnormal_respiratory_system0.76942102
110MP0002295_abnormal_pulmonary_circulatio0.75745802
111MP0008932_abnormal_embryonic_tissue0.75528579
112MP0000003_abnormal_adipose_tissue0.75286142
113MP0003861_abnormal_nervous_system0.73362930
114MP0002998_abnormal_bone_remodeling0.73119266
115MP0005369_muscle_phenotype0.73054294
116MP0004133_heterotaxia0.72563025
117MP0001243_abnormal_dermal_layer0.72486953
118MP0002697_abnormal_eye_size0.71601509
119MP0003279_aneurysm0.71190693
120MP0000767_abnormal_smooth_muscle0.71149736
121MP0003880_abnormal_central_pattern0.70481525
122MP0004197_abnormal_fetal_growth/weight/0.69611371
123MP0005595_abnormal_vascular_smooth0.69605289
124MP0002557_abnormal_social/conspecific_i0.69175339
125MP0002089_abnormal_postnatal_growth/wei0.69160357
126MP0003077_abnormal_cell_cycle0.69151500
127MP0003950_abnormal_plasma_membrane0.68559689
128MP0000639_abnormal_adrenal_gland0.68106502
129MP0003936_abnormal_reproductive_system0.68037804
130MP0003283_abnormal_digestive_organ0.67113552
131MP0010094_abnormal_chromosome_stability0.67052102
132MP0000751_myopathy0.64801799
133MP0008057_abnormal_DNA_replication0.64610429
134MP0003693_abnormal_embryo_hatching0.64255435
135MP0001270_distended_abdomen0.64179405
136MP0000013_abnormal_adipose_tissue0.59637565
137MP0001943_abnormal_respiration0.58443292
138MP0002396_abnormal_hematopoietic_system0.57985972
139MP0000467_abnormal_esophagus_morphology0.57706817
140MP0008770_decreased_survivor_rate0.56797847
141MP0001672_abnormal_embryogenesis/_devel0.56727484
142MP0005380_embryogenesis_phenotype0.56727484

Predicted human phenotypes

RankGene SetZ-score
1Calcaneovalgus deformity (HP:0001848)5.33954776
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.20264542
3Short 4th metacarpal (HP:0010044)5.20264542
4Premature rupture of membranes (HP:0001788)5.12444275
5* Abnormality of the parietal bone (HP:0002696)5.02816618
6Deformed tarsal bones (HP:0008119)4.73258301
7Abnormality of the calcaneus (HP:0008364)4.39380264
8* Midline defect of the nose (HP:0004122)4.35537535
9Trigonocephaly (HP:0000243)4.29003756
10Nasolacrimal duct obstruction (HP:0000579)4.16595176
11White forelock (HP:0002211)3.73104626
12Abnormality of the nasolacrimal system (HP:0000614)3.63419562
13Abnormality of the 4th metacarpal (HP:0010012)3.58910342
14Abnormality of the nasal septum (HP:0000419)3.55339334
15Genu recurvatum (HP:0002816)3.50091076
16Shallow orbits (HP:0000586)3.49481895
17Abnormality of the lacrimal duct (HP:0011481)3.46651028
18Bladder diverticulum (HP:0000015)3.42808855
19Neonatal short-limb short stature (HP:0008921)3.40096390
20Abnormality of the diencephalon (HP:0010662)3.38207429
21Patchy hypopigmentation of hair (HP:0011365)3.36597845
22Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.33514125
23Soft skin (HP:0000977)3.31905150
24Atrophic scars (HP:0001075)3.28272869
25Coronal craniosynostosis (HP:0004440)3.25632042
26Abnormality of the aortic arch (HP:0012303)3.24410767
27Broad metatarsal (HP:0001783)3.23569660
28Aplasia involving bones of the extremities (HP:0009825)3.23134201
29Aplasia involving bones of the upper limbs (HP:0009823)3.23134201
30Aplasia of the phalanges of the hand (HP:0009802)3.23134201
31Fragile skin (HP:0001030)3.15023814
32Abnormality of incisor morphology (HP:0011063)3.12061646
33Anteriorly placed anus (HP:0001545)3.07048857
34Alacrima (HP:0000522)3.06500778
35Abnormality of the incisor (HP:0000676)3.05409941
36Supernumerary ribs (HP:0005815)3.04905378
37Partial duplication of the phalanx of hand (HP:0009999)3.02644214
38Aortic dissection (HP:0002647)2.94815869
39Peritonitis (HP:0002586)2.94637651
40Supernumerary bones of the axial skeleton (HP:0009144)2.86945220
41Abnormal number of incisors (HP:0011064)2.85589813
42Vitreoretinal degeneration (HP:0000655)2.82283895
43Microglossia (HP:0000171)2.81860464
44Ulnar bowing (HP:0003031)2.81029689
45Mitral valve prolapse (HP:0001634)2.78609817
46Synostosis involving the elbow (HP:0003938)2.77442250
47Humeroradial synostosis (HP:0003041)2.77442250
48Abnormality of the distal phalanx of the thumb (HP:0009617)2.76837381
49Deviation of the hallux (HP:0010051)2.72210323
50Bell-shaped thorax (HP:0001591)2.69127503
51Lymphangioma (HP:0100764)2.68709030
52Concave nail (HP:0001598)2.67789474
53Neoplasm of the heart (HP:0100544)2.65391031
54Abnormality of dentin (HP:0010299)2.65384048
55Decreased lacrimation (HP:0000633)2.64809871
56Biconcave vertebral bodies (HP:0004586)2.62940723
57Abnormality of the labia minora (HP:0012880)2.61041036
58Increased number of teeth (HP:0011069)2.60670814
59Hallux valgus (HP:0001822)2.60652728
60Short middle phalanx of the 5th finger (HP:0004220)2.57906666
61Broad toe (HP:0001837)2.57414376
62Abnormality of the ischium (HP:0003174)2.56740843
63Anophthalmia (HP:0000528)2.55148391
64Turricephaly (HP:0000262)2.53509059
65Toxemia of pregnancy (HP:0100603)2.48715928
66Metaphyseal cupping (HP:0003021)2.46506938
67Mesomelia (HP:0003027)2.46337921
68Broad long bones (HP:0005622)2.45263651
69Conical tooth (HP:0000698)2.44240522
70Bowel diverticulosis (HP:0005222)2.43171544
71Broad palm (HP:0001169)2.42051484
72Partial duplication of thumb phalanx (HP:0009944)2.40633795
73Broad hallux (HP:0010055)2.38827126
74Narrow palate (HP:0000189)2.34917867
75Hyperextensible skin (HP:0000974)2.33758800
76Abnormality of the phalanges of the 2nd finger (HP:0009541)2.32957162
77Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31918032
78Down-sloping shoulders (HP:0200021)2.31883820
79Broad phalanx (HP:0006009)2.30529554
80Blue sclerae (HP:0000592)2.29794079
81Thin ribs (HP:0000883)2.28577451
82Delayed epiphyseal ossification (HP:0002663)2.26832634
83Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25723197
84Cutaneous finger syndactyly (HP:0010554)2.24930459
85Short phalanx of the thumb (HP:0009660)2.22440308
86Cervical subluxation (HP:0003308)2.21514530
87Hypoplasia of the maxilla (HP:0000327)2.19377482
88Short 5th finger (HP:0009237)2.19269375
89Cupped ribs (HP:0000887)2.15631386
90Broad phalanges of the hand (HP:0009768)2.15191843
91Hypoplastic labia majora (HP:0000059)2.13640639
92Aplasia/Hypoplasia of the clavicles (HP:0006710)2.13554318
93Broad finger (HP:0001500)2.12863901
94Follicular hyperkeratosis (HP:0007502)2.11230600
95Large earlobe (HP:0009748)2.09636100
96Infantile muscular hypotonia (HP:0008947)2.09400777
97Abnormality of the radial head (HP:0003995)2.08988951
98Ectopia lentis (HP:0001083)2.08763273
99Osteoarthritis (HP:0002758)2.07806814
100High anterior hairline (HP:0009890)2.07568749
101Long nose (HP:0003189)2.07529388
102Breech presentation (HP:0001623)2.07329422
103Recurrent corneal erosions (HP:0000495)2.06928965
104Broad face (HP:0000283)2.06739935
105Flat capital femoral epiphysis (HP:0003370)2.05317774
106Broad distal phalanx of finger (HP:0009836)2.05277917
107Broad thumb (HP:0011304)2.05185138
108Short clavicles (HP:0000894)2.03251926
109Joint laxity (HP:0001388)2.03213609
110Sparse lateral eyebrow (HP:0005338)2.03188428
111Abnormality of the middle phalanges of the hand (HP:0009833)2.02355518
112Abnormality of the antihelix (HP:0009738)1.99495845
113Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.94248007
114Cutaneous syndactyly (HP:0012725)1.93792173
115Absent eyebrow (HP:0002223)1.93589883
116Flat cornea (HP:0007720)1.92145671
117Preaxial foot polydactyly (HP:0001841)1.91650535
118Abnormality of the labia majora (HP:0012881)1.91359284
119Rectovaginal fistula (HP:0000143)1.90582091
120Rectal fistula (HP:0100590)1.90582091
121Septo-optic dysplasia (HP:0100842)1.90526521
122Abnormal delivery (HP:0001787)1.90136792
123Mild short stature (HP:0003502)1.89711968
124Atresia of the external auditory canal (HP:0000413)1.88433850
125Chorioretinal atrophy (HP:0000533)1.88134224
126Abnormality of the distal phalanges of the toes (HP:0010182)1.87537935
127Neoplasm of the oral cavity (HP:0100649)1.87532755
128Irregular epiphyses (HP:0010582)1.86368957
129Hypoplastic ischia (HP:0003175)1.86226852
130Inguinal hernia (HP:0000023)1.85781356
131Breast hypoplasia (HP:0003187)1.85264515
132Mixed hearing impairment (HP:0000410)1.85045026
133Syringomyelia (HP:0003396)1.85037444
134Spinal cord lesions (HP:0100561)1.85037444
135Venous insufficiency (HP:0005293)1.84199148
136Short metatarsal (HP:0010743)1.83448308
137Shawl scrotum (HP:0000049)1.83406897
138Intestinal fistula (HP:0100819)1.82997007
139Mitral regurgitation (HP:0001653)1.82732983
140Bilateral microphthalmos (HP:0007633)1.82395364
141Annular pancreas (HP:0001734)1.82161221
142Wide anterior fontanel (HP:0000260)1.82092895
143Hyperacusis (HP:0010780)1.80460751
144Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.80432622
145Thin bony cortex (HP:0002753)1.79884707
146Blue irides (HP:0000635)1.79570916
147Short palpebral fissure (HP:0012745)1.78970948
148Cupped ear (HP:0000378)1.78672351
149Congenital sensorineural hearing impairment (HP:0008527)1.78344055
150Thoracolumbar scoliosis (HP:0002944)1.78242022
151Duplication of thumb phalanx (HP:0009942)1.78182655
152Tracheomalacia (HP:0002779)1.77950511
153Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.76870932
154Omphalocele (HP:0001539)1.76373566
155Hypotelorism (HP:0000601)1.75628481
156Depressed nasal tip (HP:0000437)1.75098267
157Ectopic anus (HP:0004397)1.74692670
158Abnormality of the phalanges of the hallux (HP:0010057)1.73098673
159Medulloblastoma (HP:0002885)1.72894325
160Morphological abnormality of the middle ear (HP:0008609)1.72558029
161Protrusio acetabuli (HP:0003179)1.71618154
162Hepatoblastoma (HP:0002884)1.71144093
163* Telecanthus (HP:0000506)1.70832154
164Renal duplication (HP:0000075)1.70511472
165Narrow nasal bridge (HP:0000446)1.69252305
166Protruding ear (HP:0000411)1.68219514
167Heterochromia iridis (HP:0001100)1.67708327
168Aqueductal stenosis (HP:0002410)1.67237238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.88173360
2CASK4.70854311
3EEF2K4.66793661
4LATS13.53022725
5TRIB33.39778725
6FGFR23.38601889
7TAOK33.25422901
8DDR22.91207085
9SIK32.83968409
10SIK12.62703794
11RIPK12.53687785
12EPHB22.49997871
13MKNK22.47895352
14ICK2.25561203
15SMG12.20399662
16CAMK1G2.09295214
17INSRR2.00351291
18NUAK11.92251075
19AKT31.87629807
20MKNK11.87376546
21PRKD31.76948483
22PRPF4B1.76536843
23CAMK1D1.69322544
24RPS6KC11.68315840
25RPS6KL11.68315840
26STK38L1.67519253
27TTK1.67049365
28PIK3CA1.65199390
29MTOR1.64365112
30TNIK1.59057224
31PDGFRA1.56404509
32SIK21.55597421
33MAPK131.55075174
34RPS6KA61.54583962
35NLK1.49171001
36EPHA31.45547871
37NTRK31.42740911
38CDK31.39577179
39EPHA41.35278529
40CDK41.34519600
41FGFR11.34212328
42TYRO31.33361014
43BMPR1B1.32909755
44CDK81.25207922
45CDC71.20903109
46ZAK1.20867082
47EIF2AK21.18320773
48STK31.15349621
49NEK21.14873388
50BRD41.08787461
51BUB11.04433073
52NTRK11.03347122
53FER1.02584413
54YES11.01331081
55CSNK1A1L0.99456783
56MARK20.99419098
57SGK20.99080623
58MAP2K70.98748712
59DMPK0.97757190
60RPS6KA20.95482917
61CDK120.92662863
62TAOK20.91841246
63CHEK10.91819297
64STK40.91060457
65PRKCE0.90988459
66TGFBR20.90453458
67LATS20.90048999
68PDGFRB0.89154755
69PLK20.88805973
70TTN0.88536174
71MAPK70.88532502
72NTRK20.86911427
73FGFR40.86468208
74CAMK40.85924605
75PNCK0.85027209
76ERBB30.84409775
77ATR0.80057567
78PAK60.76968314
79CDK20.76289578
80PAK20.76180983
81IRAK10.74234108
82PKN10.71599852
83CDK90.71461130
84CDK10.71052822
85WNK10.69598775
86DYRK20.69423606
87AKT20.68219568
88MAPK150.68091760
89STK160.67881293
90DAPK10.67844967
91GRK70.67408525
92SGK2230.65984430
93SGK4940.65984430
94PKN20.64852024
95TNK20.63764503
96PRKD20.62650743
97AURKA0.62007910
98IRAK20.61593711
99ERBB20.60484579
100CDK11A0.59035776
101SGK30.58503567
102CAMK10.58053715
103MAPK110.57238111
104ADRBK20.57108445
105TXK0.57016159
106CLK10.56639163
107SRPK10.56349061
108PRKAA20.56065154
109CDC42BPA0.55017960
110CHUK0.54840029
111MAPKAPK50.54124505
112BMX0.52013408
113RPS6KB20.51767891
114DYRK1B0.50800716
115PLK10.50769204
116MOS0.50724554
117CSNK1G10.50403649
118CDK150.49559977
119DAPK20.49318881
120CHEK20.47870807
121ADRBK10.47787787
122RET0.45998721
123PLK30.45658204
124DYRK1A0.45146387
125NEK60.44721294
126ATM0.44125541
127ALK0.43018300
128VRK10.42980482
129PASK0.42861076
130BRSK10.42409268
131PTK20.41319583
132GRK10.41081503
133MAP3K80.40423573
134CDK180.40075348
135CDK70.39908048
136CSNK1E0.38769667
137MELK0.38525019
138CDK140.38396840
139MAP2K20.38068823
140MAPK80.38053408
141PRKG10.37757082
142MAPK140.37744025
143MARK30.36655893
144NEK90.36277881
145PRKCH0.35844522
146ROCK10.35730114
147AURKB0.35282418
148MAPK90.35068174
149SGK10.34978584
150PRKDC0.34840484
151GSK3B0.34633298
152BLK0.34573723
153MAPK10.34269031
154WNK30.34023561
155MAPK100.33985351
156CSNK1A10.33660326
157IGF1R0.31830926
158MAP3K40.31741102
159AKT10.31147514
160MAP3K70.30750525
161PRKAA10.30571319
162MAPK30.29491352
163PTK60.28519549

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.87095807
2Hedgehog signaling pathway_Homo sapiens_hsa043404.26540691
3DNA replication_Homo sapiens_hsa030302.62198623
4Wnt signaling pathway_Homo sapiens_hsa043102.54867341
5Nicotine addiction_Homo sapiens_hsa050332.31729554
6Melanoma_Homo sapiens_hsa052182.22860517
7Axon guidance_Homo sapiens_hsa043602.21839290
8ECM-receptor interaction_Homo sapiens_hsa045122.09668637
9Sulfur relay system_Homo sapiens_hsa041221.92937914
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.89017827
11Base excision repair_Homo sapiens_hsa034101.84793920
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79284451
13TGF-beta signaling pathway_Homo sapiens_hsa043501.78616145
14Hippo signaling pathway_Homo sapiens_hsa043901.77964024
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76748232
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.74260069
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74113623
18Cell cycle_Homo sapiens_hsa041101.71115497
19Spliceosome_Homo sapiens_hsa030401.51041720
20Melanogenesis_Homo sapiens_hsa049161.50675958
21Prostate cancer_Homo sapiens_hsa052151.49558960
22Taste transduction_Homo sapiens_hsa047421.48924259
23Pathways in cancer_Homo sapiens_hsa052001.48348357
24Morphine addiction_Homo sapiens_hsa050321.45874803
25Protein digestion and absorption_Homo sapiens_hsa049741.40916304
26Non-small cell lung cancer_Homo sapiens_hsa052231.38245374
27Mismatch repair_Homo sapiens_hsa034301.37616111
28cAMP signaling pathway_Homo sapiens_hsa040241.36891103
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36806290
30Adherens junction_Homo sapiens_hsa045201.35835328
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34659875
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31737443
33Dilated cardiomyopathy_Homo sapiens_hsa054141.30860642
34Nucleotide excision repair_Homo sapiens_hsa034201.30716297
35Circadian entrainment_Homo sapiens_hsa047131.25576664
36Lysine degradation_Homo sapiens_hsa003101.25297646
37Homologous recombination_Homo sapiens_hsa034401.22626811
38Renin secretion_Homo sapiens_hsa049241.21944326
39Glutamatergic synapse_Homo sapiens_hsa047241.21048095
40Bladder cancer_Homo sapiens_hsa052191.20007147
41mRNA surveillance pathway_Homo sapiens_hsa030151.18385672
42Thyroid cancer_Homo sapiens_hsa052161.17953223
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15318668
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12618863
45Serotonergic synapse_Homo sapiens_hsa047261.12497800
46RNA transport_Homo sapiens_hsa030131.10670140
47Pancreatic cancer_Homo sapiens_hsa052121.09279921
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.09214038
49Focal adhesion_Homo sapiens_hsa045101.07452461
50Proteoglycans in cancer_Homo sapiens_hsa052051.07249980
51Calcium signaling pathway_Homo sapiens_hsa040201.06499358
52Ovarian steroidogenesis_Homo sapiens_hsa049131.05918646
53Rap1 signaling pathway_Homo sapiens_hsa040151.04881982
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04211693
55MicroRNAs in cancer_Homo sapiens_hsa052061.03272808
56Ras signaling pathway_Homo sapiens_hsa040141.03006646
57Cocaine addiction_Homo sapiens_hsa050301.02065603
58GABAergic synapse_Homo sapiens_hsa047271.00709311
59Acute myeloid leukemia_Homo sapiens_hsa052210.99935544
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98208736
61Colorectal cancer_Homo sapiens_hsa052100.97673424
62Phototransduction_Homo sapiens_hsa047440.96275791
63Amphetamine addiction_Homo sapiens_hsa050310.94863404
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.92567843
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92190348
66MAPK signaling pathway_Homo sapiens_hsa040100.89345237
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89134152
68AMPK signaling pathway_Homo sapiens_hsa041520.88455011
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88409965
70Notch signaling pathway_Homo sapiens_hsa043300.87117018
71One carbon pool by folate_Homo sapiens_hsa006700.87068688
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86916885
73mTOR signaling pathway_Homo sapiens_hsa041500.85939518
74ErbB signaling pathway_Homo sapiens_hsa040120.85886769
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85037541
76Type II diabetes mellitus_Homo sapiens_hsa049300.83719211
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83612647
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83358085
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81949108
80Insulin secretion_Homo sapiens_hsa049110.81852954
81Cholinergic synapse_Homo sapiens_hsa047250.81614354
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78319898
83Amoebiasis_Homo sapiens_hsa051460.77512976
84Fanconi anemia pathway_Homo sapiens_hsa034600.76788216
85Oxytocin signaling pathway_Homo sapiens_hsa049210.76645721
86Olfactory transduction_Homo sapiens_hsa047400.76563356
87Circadian rhythm_Homo sapiens_hsa047100.76465891
88Renal cell carcinoma_Homo sapiens_hsa052110.74712377
89Long-term depression_Homo sapiens_hsa047300.73687898
90Small cell lung cancer_Homo sapiens_hsa052220.70303529
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.69914797
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.69668398
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.67775513
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66400614
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66230284
96Retinol metabolism_Homo sapiens_hsa008300.65267355
97Vitamin digestion and absorption_Homo sapiens_hsa049770.62352067
98Salivary secretion_Homo sapiens_hsa049700.61260920
99Glioma_Homo sapiens_hsa052140.61023819
100Fructose and mannose metabolism_Homo sapiens_hsa000510.59599547
101HTLV-I infection_Homo sapiens_hsa051660.59595068
102Endometrial cancer_Homo sapiens_hsa052130.58924878
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57207919
104Dopaminergic synapse_Homo sapiens_hsa047280.56973814
105VEGF signaling pathway_Homo sapiens_hsa043700.56333205
106Inositol phosphate metabolism_Homo sapiens_hsa005620.55145585
107African trypanosomiasis_Homo sapiens_hsa051430.54188999
108Choline metabolism in cancer_Homo sapiens_hsa052310.52111245
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51962497
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50483025
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50065860
112Chronic myeloid leukemia_Homo sapiens_hsa052200.49471100
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49419254
114Ribosome_Homo sapiens_hsa030100.48930875
115Gap junction_Homo sapiens_hsa045400.47308939
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46119448
117N-Glycan biosynthesis_Homo sapiens_hsa005100.46002184
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45715351
119Insulin signaling pathway_Homo sapiens_hsa049100.45079502
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43364925
121Basal transcription factors_Homo sapiens_hsa030220.41949586
122Pyrimidine metabolism_Homo sapiens_hsa002400.41785181
123Long-term potentiation_Homo sapiens_hsa047200.41468680
124Hepatitis B_Homo sapiens_hsa051610.40772648
125Non-homologous end-joining_Homo sapiens_hsa034500.40552785
126Autoimmune thyroid disease_Homo sapiens_hsa053200.40193489
127Prolactin signaling pathway_Homo sapiens_hsa049170.40051262
128GnRH signaling pathway_Homo sapiens_hsa049120.39992455
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39835070
130Estrogen signaling pathway_Homo sapiens_hsa049150.39615015
131FoxO signaling pathway_Homo sapiens_hsa040680.39184156
132Pentose phosphate pathway_Homo sapiens_hsa000300.38782741
133Biosynthesis of amino acids_Homo sapiens_hsa012300.38233214
134Ether lipid metabolism_Homo sapiens_hsa005650.38019073
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36622274
136Rheumatoid arthritis_Homo sapiens_hsa053230.36385092
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35953939
138Oocyte meiosis_Homo sapiens_hsa041140.35750996
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35748476
140Sphingolipid metabolism_Homo sapiens_hsa006000.35514148
141Dorso-ventral axis formation_Homo sapiens_hsa043200.34507015
142p53 signaling pathway_Homo sapiens_hsa041150.34285196
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.33477284
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.33277701
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33244621
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.32788785
147Malaria_Homo sapiens_hsa051440.31935641

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