ALYREF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.40968137
2transcription from mitochondrial promoter (GO:0006390)6.68274756
3embryonic process involved in female pregnancy (GO:0060136)6.37662495
4proline metabolic process (GO:0006560)6.11800039
5DNA deamination (GO:0045006)5.86420849
6establishment of apical/basal cell polarity (GO:0035089)5.38906064
7positive regulation of protein homooligomerization (GO:0032464)5.35819046
8mitotic chromosome condensation (GO:0007076)5.28995302
9somatic hypermutation of immunoglobulin genes (GO:0016446)5.16460765
10somatic diversification of immune receptors via somatic mutation (GO:0002566)5.16460765
11regulation of integrin activation (GO:0033623)5.06152950
12DNA strand renaturation (GO:0000733)4.90084248
13nuclear pore complex assembly (GO:0051292)4.79691973
14telomere maintenance via semi-conservative replication (GO:0032201)4.79037496
15* replication fork processing (GO:0031297)4.72720031
16oxidative demethylation (GO:0070989)4.64388712
17establishment of monopolar cell polarity (GO:0061162)4.63810125
18establishment or maintenance of monopolar cell polarity (GO:0061339)4.63810125
19mitochondrial DNA metabolic process (GO:0032042)4.53525559
20formation of translation preinitiation complex (GO:0001731)4.53309111
21mitotic G1 DNA damage checkpoint (GO:0031571)4.49642597
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.38879994
23* maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.38182017
24regulation of protein homooligomerization (GO:0032462)4.34161636
25poly(A)+ mRNA export from nucleus (GO:0016973)4.27118025
26nucleotide-excision repair, DNA gap filling (GO:0006297)4.25925905
27DNA strand elongation involved in DNA replication (GO:0006271)4.18878188
28nuclear pore organization (GO:0006999)4.18305520
29regulation of translational fidelity (GO:0006450)4.17426019
30ribosomal small subunit biogenesis (GO:0042274)4.17079105
31base-excision repair (GO:0006284)4.17024356
32regulation of translational termination (GO:0006449)4.16396472
33dosage compensation (GO:0007549)4.10994654
34heterochromatin organization (GO:0070828)4.09824175
35G1 DNA damage checkpoint (GO:0044783)4.05480060
36DNA double-strand break processing (GO:0000729)4.04124872
37protein localization to chromosome, centromeric region (GO:0071459)4.03607649
38mRNA cleavage (GO:0006379)4.02583627
39telomere maintenance via recombination (GO:0000722)4.01644155
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.99252591
41meiotic chromosome segregation (GO:0045132)3.99029773
42negative regulation of mRNA processing (GO:0050686)3.98392301
43DNA topological change (GO:0006265)3.96862877
44DNA strand elongation (GO:0022616)3.94091404
45mitotic G1/S transition checkpoint (GO:0044819)3.93642417
46regulation of mammary gland epithelial cell proliferation (GO:0033599)3.90897209
47negative regulation of cell cycle arrest (GO:0071157)3.90252748
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.89744769
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.89744769
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.89744769
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.88223802
52regulation of double-strand break repair via homologous recombination (GO:0010569)3.80559574
53kinetochore assembly (GO:0051382)3.73923327
54protein complex localization (GO:0031503)3.73484430
55negative regulation of JAK-STAT cascade (GO:0046426)3.73376152
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.70665382
57negative regulation of RNA splicing (GO:0033119)3.69428774
58non-recombinational repair (GO:0000726)3.69202498
59double-strand break repair via nonhomologous end joining (GO:0006303)3.69202498
60DNA ligation (GO:0006266)3.68791902
61peptidyl-arginine omega-N-methylation (GO:0035247)3.68632252
62DNA integration (GO:0015074)3.64370834
63chromatin assembly (GO:0031497)3.63738657
64nucleobase-containing small molecule interconversion (GO:0015949)3.63631380
65regulation of sister chromatid cohesion (GO:0007063)3.63568788
66embryonic placenta development (GO:0001892)3.63062225
67mitotic recombination (GO:0006312)3.62136384
68pore complex assembly (GO:0046931)3.60845271
69regulation of posttranscriptional gene silencing (GO:0060147)3.58241764
70regulation of gene silencing by miRNA (GO:0060964)3.58241764
71regulation of gene silencing by RNA (GO:0060966)3.58241764
72kinetochore organization (GO:0051383)3.57400187
73maturation of SSU-rRNA (GO:0030490)3.57291513
74regulation of double-strand break repair (GO:2000779)3.55172776
75establishment of integrated proviral latency (GO:0075713)3.53632172
76folic acid-containing compound biosynthetic process (GO:0009396)3.53060221
77mitotic metaphase plate congression (GO:0007080)3.52957317
78regulation of RNA export from nucleus (GO:0046831)3.52502817
79mitotic sister chromatid segregation (GO:0000070)3.52180769
80histone H4-K12 acetylation (GO:0043983)3.49024274
81cellular protein complex localization (GO:0034629)3.48820409
82mitotic sister chromatid cohesion (GO:0007064)3.45604311
83telomere maintenance via telomere lengthening (GO:0010833)3.41372050
84maturation of 5.8S rRNA (GO:0000460)3.41360543
85DNA duplex unwinding (GO:0032508)3.39984137
86pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.37603350
87positive regulation of chromosome segregation (GO:0051984)3.37501128
88protein localization to kinetochore (GO:0034501)3.36564689
89mitochondrial RNA metabolic process (GO:0000959)3.36459996
90positive regulation by host of viral transcription (GO:0043923)3.34799517
91positive regulation of protein oligomerization (GO:0032461)3.34332544
92cellular response to zinc ion (GO:0071294)3.34314536
93DNA replication checkpoint (GO:0000076)3.33233424
94cellular response to ATP (GO:0071318)3.32828518
95chromosome condensation (GO:0030261)3.32718849
96base-excision repair, AP site formation (GO:0006285)3.32480379
97positive regulation of developmental pigmentation (GO:0048087)3.29937735
98ribonucleoprotein complex biogenesis (GO:0022613)3.29081115
99trophectodermal cell differentiation (GO:0001829)3.25883807
100* termination of RNA polymerase II transcription (GO:0006369)3.25773570
101regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25458040
102nuclear envelope disassembly (GO:0051081)3.23941435
103membrane disassembly (GO:0030397)3.23941435
104embryonic camera-type eye development (GO:0031076)3.22498693
105rRNA transcription (GO:0009303)3.19988923
106DNA geometric change (GO:0032392)3.18982653
107negative regulation of mRNA metabolic process (GO:1903312)3.17188449
108regulation of DNA damage checkpoint (GO:2000001)3.15568612
109sister chromatid segregation (GO:0000819)3.11461761
110histone arginine methylation (GO:0034969)3.11166209
111resolution of meiotic recombination intermediates (GO:0000712)3.10629372
112apoptotic process involved in morphogenesis (GO:0060561)3.09986201
113negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.07926504
114nuclear envelope reassembly (GO:0031468)3.07402200
115mitotic nuclear envelope reassembly (GO:0007084)3.07402200
116face development (GO:0060324)3.04408475
117DNA conformation change (GO:0071103)3.04143837
118negative regulation of Ras GTPase activity (GO:0034261)3.03608429
119DNA replication-dependent nucleosome organization (GO:0034723)3.03585362
120RNA stabilization (GO:0043489)3.03391398
121mRNA stabilization (GO:0048255)3.03391398
122ribosome assembly (GO:0042255)3.03192371
123positive regulation of DNA repair (GO:0045739)3.03014094
124glutamine family amino acid biosynthetic process (GO:0009084)2.98175813
125peptidyl-arginine N-methylation (GO:0035246)2.97954411
126peptidyl-arginine methylation (GO:0018216)2.97954411
127chromatin assembly or disassembly (GO:0006333)2.97805836
128convergent extension (GO:0060026)2.97077482
129negative regulation of fatty acid biosynthetic process (GO:0045717)2.95705694
130protein-DNA complex disassembly (GO:0032986)2.95677114
131nucleosome disassembly (GO:0006337)2.95677114
132mitotic nuclear envelope disassembly (GO:0007077)2.93065112
133COPI coating of Golgi vesicle (GO:0048205)2.90923267
134Golgi transport vesicle coating (GO:0048200)2.90923267
135DNA replication initiation (GO:0006270)2.87368386
136regulation of protein oligomerization (GO:0032459)2.83348157
137determination of adult lifespan (GO:0008340)2.82361363
138positive regulation of DNA-dependent DNA replication (GO:2000105)2.81583765
139DNA packaging (GO:0006323)2.80948670
140establishment of viral latency (GO:0019043)2.80078836
141nodal signaling pathway (GO:0038092)2.79688950
142regulation of DNA repair (GO:0006282)2.79666567
143DNA synthesis involved in DNA repair (GO:0000731)2.79410735
144DNA unwinding involved in DNA replication (GO:0006268)2.79144933
145anatomical structure regression (GO:0060033)2.77424499
146pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.76928046
147IMP biosynthetic process (GO:0006188)2.76348611
148folic acid metabolic process (GO:0046655)2.74335897
149ribosome biogenesis (GO:0042254)2.74212396
150rRNA processing (GO:0006364)2.72375939
151nuclear envelope organization (GO:0006998)2.72184765
152DNA replication-dependent nucleosome assembly (GO:0006335)2.71958958
153pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.69116047
154metaphase plate congression (GO:0051310)2.68057560
155positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.67191300
156pentose-phosphate shunt (GO:0006098)2.65122467
157* mRNA splicing, via spliceosome (GO:0000398)2.65093652
158* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.65093652
1593-UTR-mediated mRNA stabilization (GO:0070935)2.64697632
160regulation of chromatin binding (GO:0035561)2.61611323
161establishment of chromosome localization (GO:0051303)2.61294684
162ribosomal large subunit biogenesis (GO:0042273)2.60424318
163regulation of translational elongation (GO:0006448)2.59239032
164* RNA splicing, via transesterification reactions (GO:0000375)2.59126895
165viral transcription (GO:0019083)2.58902875
166mitochondrial fusion (GO:0008053)2.56925575
167protein export from nucleus (GO:0006611)2.55741722
168trophoblast giant cell differentiation (GO:0060707)2.55374844

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.09392157
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.62637072
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.42908260
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.14628971
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90455256
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.87882639
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.87882639
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.87882639
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78577078
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.67097722
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.61994606
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54629312
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40889669
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37424465
15VDR_21846776_ChIP-Seq_THP-1_Human2.23387374
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13457503
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.06513739
18SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.02330340
19KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.01507149
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.93546702
21NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.88920608
22AR_21909140_ChIP-Seq_LNCAP_Human1.86965463
23MYC_22102868_ChIP-Seq_BL_Human1.86599230
24TCF3_18692474_ChIP-Seq_MESCs_Mouse1.83269475
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.82817875
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.81201312
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79613064
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78374070
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76606597
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74082095
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73585847
32CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.70773257
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.70150121
34POU5F1_16518401_ChIP-PET_MESCs_Mouse1.69330365
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68191720
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67734354
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.66439922
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66421306
39NANOG_21062744_ChIP-ChIP_HESCs_Human1.62839396
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61456439
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.60931106
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60495154
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.58128326
44XRN2_22483619_ChIP-Seq_HELA_Human1.57140969
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56180722
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54685327
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.54163973
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.53839597
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52252784
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50222898
51DCP1A_22483619_ChIP-Seq_HELA_Human1.49174154
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48412492
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48239285
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47405184
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45772737
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43781701
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43202898
58HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.42486771
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.42209867
60TTF2_22483619_ChIP-Seq_HELA_Human1.40245183
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38561765
62GABP_19822575_ChIP-Seq_HepG2_Human1.37748924
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37666428
64PU.1_20513432_ChIP-Seq_Bcells_Mouse1.35210304
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35052205
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32433939
67NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30312855
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.29967727
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29112095
70NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.28335707
71KDM5A_27292631_Chip-Seq_BREAST_Human1.28307791
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.27843688
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26986211
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26853900
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26006828
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25079471
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24527673
78CIITA_25753668_ChIP-Seq_RAJI_Human1.23732389
79POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23388306
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22652317
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22498381
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22078691
83VDR_23849224_ChIP-Seq_CD4+_Human1.21953632
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19661453
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19558391
86LXR_22292898_ChIP-Seq_THP-1_Human1.19411204
87SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17439216
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15813211
89SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14597523
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14165949
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.12014291
92GABP_17652178_ChIP-ChIP_JURKAT_Human1.11831610
93TCF7_22412390_ChIP-Seq_EML_Mouse1.10908692
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10147079
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09786849
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08673544
97FOXP3_21729870_ChIP-Seq_TREG_Human1.08485938
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.07752478
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07222995
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07139296
101ATF3_27146783_Chip-Seq_COLON_Human1.07025169
102OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06703365
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.06515200
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06193070
105CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06085017
106NANOG_18692474_ChIP-Seq_MESCs_Mouse1.05960080
107KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05362100
108ZNF263_19887448_ChIP-Seq_K562_Human1.04643197
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04585521
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02518137
111TFEB_21752829_ChIP-Seq_HELA_Human1.02472431
112HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02463159
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02083518
114MAF_26560356_Chip-Seq_TH1_Human1.00947171
115STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00761023
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99918100
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99786209
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99384922
119KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99090313
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98627054
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98388636
122RACK7_27058665_Chip-Seq_MCF-7_Human0.97939712
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97839324
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97051300
125ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96552366
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96236719
127NCOR1_26117541_ChIP-Seq_K562_Human0.95674336
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95662757
129EGR1_19374776_ChIP-ChIP_THP-1_Human0.95356229
130CHD1_26751641_Chip-Seq_LNCaP_Human0.94660364
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94634933
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94109154
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93855309
134KDM2B_26808549_Chip-Seq_DND41_Human0.93497141
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93393402
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91609535
137MAF_26560356_Chip-Seq_TH2_Human0.90393986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.99770087
2MP0009278_abnormal_bone_marrow3.72257815
3MP0010030_abnormal_orbit_morphology3.50840281
4MP0005171_absent_coat_pigmentation3.50164804
5MP0010094_abnormal_chromosome_stability3.43073161
6MP0002877_abnormal_melanocyte_morpholog3.20768262
7MP0004957_abnormal_blastocyst_morpholog2.86227217
8MP0002009_preneoplasia2.79857408
9MP0003111_abnormal_nucleus_morphology2.68598836
10MP0004185_abnormal_adipocyte_glucose2.60150478
11MP0010234_abnormal_vibrissa_follicle2.58501709
12MP0003693_abnormal_embryo_hatching2.49887686
13MP0004233_abnormal_muscle_weight2.33753704
14MP0005451_abnormal_body_composition2.33021171
15MP0003077_abnormal_cell_cycle2.28697500
16MP0003890_abnormal_embryonic-extraembry2.25371930
17MP0000537_abnormal_urethra_morphology2.19731196
18MP0008058_abnormal_DNA_repair2.19540770
19MP0003786_premature_aging2.18348798
20MP0010352_gastrointestinal_tract_polyps2.18344322
21MP0008995_early_reproductive_senescence2.07355406
22MP0008932_abnormal_embryonic_tissue2.04891852
23MP0005397_hematopoietic_system_phenotyp2.03492165
24MP0001545_abnormal_hematopoietic_system2.03492165
25MP0005076_abnormal_cell_differentiation1.90799180
26MP0005623_abnormal_meninges_morphology1.88532885
27MP0005174_abnormal_tail_pigmentation1.86936476
28MP0003283_abnormal_digestive_organ1.86672996
29MP0008877_abnormal_DNA_methylation1.79487195
30MP0003119_abnormal_digestive_system1.77419492
31MP0000490_abnormal_crypts_of1.76583564
32MP0002084_abnormal_developmental_patter1.74091571
33MP0002249_abnormal_larynx_morphology1.73343247
34MP0002086_abnormal_extraembryonic_tissu1.73140281
35MP0002163_abnormal_gland_morphology1.72027212
36MP0001293_anophthalmia1.71509216
37MP0001697_abnormal_embryo_size1.71244324
38MP0004133_heterotaxia1.70432171
39MP0004197_abnormal_fetal_growth/weight/1.68984853
40MP0002085_abnormal_embryonic_tissue1.64927972
41MP0004808_abnormal_hematopoietic_stem1.64331432
42MP0000350_abnormal_cell_proliferation1.63551320
43MP0001346_abnormal_lacrimal_gland1.63218152
44MP0002282_abnormal_trachea_morphology1.58630855
45MP0003567_abnormal_fetal_cardiomyocyte1.58215173
46MP0002653_abnormal_ependyma_morphology1.57764125
47MP0006072_abnormal_retinal_apoptosis1.56637358
48MP0003453_abnormal_keratinocyte_physiol1.52460899
49MP0001672_abnormal_embryogenesis/_devel1.51525353
50MP0005380_embryogenesis_phenotype1.51525353
51MP0001730_embryonic_growth_arrest1.49562600
52MP0000678_abnormal_parathyroid_gland1.46716104
53MP0010307_abnormal_tumor_latency1.43474105
54MP0001849_ear_inflammation1.41074244
55MP0009672_abnormal_birth_weight1.34028748
56MP0000733_abnormal_muscle_development1.33006660
57MP0000015_abnormal_ear_pigmentation1.32956482
58MP0008007_abnormal_cellular_replicative1.30374062
59MP0001348_abnormal_lacrimal_gland1.30072062
60MP0001661_extended_life_span1.28496027
61MP0009053_abnormal_anal_canal1.28183497
62MP0002111_abnormal_tail_morphology1.24518989
63MP0002080_prenatal_lethality1.22078916
64MP0003984_embryonic_growth_retardation1.22024884
65MP0005075_abnormal_melanosome_morpholog1.19345287
66MP0002019_abnormal_tumor_incidence1.19153357
67MP0002088_abnormal_embryonic_growth/wei1.17988609
68MP0000371_diluted_coat_color1.14552397
69MP0003315_abnormal_perineum_morphology1.10329264
70MP0000003_abnormal_adipose_tissue1.09894426
71MP0000470_abnormal_stomach_morphology1.09731954
72MP0003763_abnormal_thymus_physiology1.09465654
73MP0002932_abnormal_joint_morphology1.05362940
74MP0005058_abnormal_lysosome_morphology1.04114496
75MP0000313_abnormal_cell_death1.02630076
76MP0005257_abnormal_intraocular_pressure1.01896573
77MP0003755_abnormal_palate_morphology1.01678942
78MP0000579_abnormal_nail_morphology1.00508258
79MP0003941_abnormal_skin_development1.00231663
80MP0002089_abnormal_postnatal_growth/wei0.99940228
81MP0003136_yellow_coat_color0.98587230
82MP0003828_pulmonary_edema0.96588253
83MP0000428_abnormal_craniofacial_morphol0.95644773
84MP0005666_abnormal_adipose_tissue0.95296573
85MP0001340_abnormal_eyelid_morphology0.94402768
86MP0000858_altered_metastatic_potential0.94355439
87MP0003718_maternal_effect0.94005247
88MP0002396_abnormal_hematopoietic_system0.93482249
89MP0000358_abnormal_cell_content/0.92664303
90MP0003935_abnormal_craniofacial_develop0.92339336
91MP0002075_abnormal_coat/hair_pigmentati0.91778462
92MP0005621_abnormal_cell_physiology0.91559184
93MP0002114_abnormal_axial_skeleton0.91107308
94MP0000762_abnormal_tongue_morphology0.90830327
95MP0003123_paternal_imprinting0.89490929
96MP0001727_abnormal_embryo_implantation0.88649810
97MP0000432_abnormal_head_morphology0.88216493
98MP0001216_abnormal_epidermal_layer0.88204456
99MP0000462_abnormal_digestive_system0.87402862
100MP0004858_abnormal_nervous_system0.86002925
101MP0003221_abnormal_cardiomyocyte_apopto0.85529222
102MP0005375_adipose_tissue_phenotype0.85113472
103MP0003385_abnormal_body_wall0.84868083
104MP0009333_abnormal_splenocyte_physiolog0.84790279
105MP0002796_impaired_skin_barrier0.84729847
106MP0001186_pigmentation_phenotype0.84131127
107MP0003942_abnormal_urinary_system0.83871677
108MP0005384_cellular_phenotype0.83086547
109MP0002116_abnormal_craniofacial_bone0.82770625
110MP0000049_abnormal_middle_ear0.82566525
111MP0005501_abnormal_skin_physiology0.82360774
112MP0001145_abnormal_male_reproductive0.80692610
113MP0005367_renal/urinary_system_phenotyp0.79856554
114MP0000516_abnormal_urinary_system0.79856554
115MP0002697_abnormal_eye_size0.79360754
116MP0001873_stomach_inflammation0.75882778
117MP0002098_abnormal_vibrissa_morphology0.75672070
118MP0001881_abnormal_mammary_gland0.73989774
119MP0003705_abnormal_hypodermis_morpholog0.73812062
120MP0002269_muscular_atrophy0.73482170
121MP0005379_endocrine/exocrine_gland_phen0.71405150
122MP0002060_abnormal_skin_morphology0.71066662
123MP0002405_respiratory_system_inflammati0.70614212
124MP0002210_abnormal_sex_determination0.70595179
125MP0002398_abnormal_bone_marrow0.70503851
126MP0004264_abnormal_extraembryonic_tissu0.69691847
127MP0001915_intracranial_hemorrhage0.68975426
128MP0006035_abnormal_mitochondrial_morpho0.68407760
129MP0000685_abnormal_immune_system0.68271571
130MP0003172_abnormal_lysosome_physiology0.68196857
131MP0002722_abnormal_immune_system0.68051022
132MP0005508_abnormal_skeleton_morphology0.67813422
133MP0002160_abnormal_reproductive_system0.67808295
134MP0000477_abnormal_intestine_morphology0.67676772
135MP0002092_abnormal_eye_morphology0.67555550
136MP0009931_abnormal_skin_appearance0.66574864
137MP0000467_abnormal_esophagus_morphology0.66483228
138MP0003566_abnormal_cell_adhesion0.66294980
139MP0005023_abnormal_wound_healing0.65720779
140MP0009379_abnormal_foot_pigmentation0.65179652
141MP0003937_abnormal_limbs/digits/tail_de0.65077407
142MP0000747_muscle_weakness0.64589292
143MP0000627_abnormal_mammary_gland0.64269969
144MP0000639_abnormal_adrenal_gland0.64227677
145MP0002166_altered_tumor_susceptibility0.63977460
146MP0000689_abnormal_spleen_morphology0.63315016
147MP0002751_abnormal_autonomic_nervous0.62745039
148MP0000703_abnormal_thymus_morphology0.62131767
149MP0003091_abnormal_cell_migration0.61296748
150MP0009250_abnormal_appendicular_skeleto0.61218415
151MP0000759_abnormal_skeletal_muscle0.59887340

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.34997602
2Facial hemangioma (HP:0000329)4.89745821
3Concave nail (HP:0001598)4.65510765
4Rectal fistula (HP:0100590)4.58771960
5Rectovaginal fistula (HP:0000143)4.58771960
6Annular pancreas (HP:0001734)4.14092851
7Intestinal fistula (HP:0100819)4.12971985
8Pustule (HP:0200039)4.12096409
9Poikiloderma (HP:0001029)4.00541199
10Vaginal fistula (HP:0004320)3.92777119
11Increased IgM level (HP:0003496)3.80493814
12Aplasia/hypoplasia of the humerus (HP:0006507)3.74689463
13Short humerus (HP:0005792)3.74590450
14Ulnar bowing (HP:0003031)3.73538485
15Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.68774699
16Hypochromic microcytic anemia (HP:0004840)3.68629851
17Absent radius (HP:0003974)3.66707576
18Progressive muscle weakness (HP:0003323)3.64062366
19Intestinal atresia (HP:0011100)3.56468166
20Abnormal hemoglobin (HP:0011902)3.55356873
21Alopecia of scalp (HP:0002293)3.53106063
22Absent thumb (HP:0009777)3.46066176
23Absent forearm bone (HP:0003953)3.44591183
24Aplasia involving forearm bones (HP:0009822)3.44591183
25Tongue fasciculations (HP:0001308)3.43092919
26Chromsome breakage (HP:0040012)3.35969285
27Turricephaly (HP:0000262)3.32520186
28Hyperacusis (HP:0010780)3.28285189
29Coronal craniosynostosis (HP:0004440)3.28067476
30Selective tooth agenesis (HP:0001592)3.25507907
31Patellar aplasia (HP:0006443)3.24758763
32Orthostatic hypotension (HP:0001278)3.21014280
33Vertebral hypoplasia (HP:0008417)3.17474058
34Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.17474058
35Muscle fibrillation (HP:0010546)3.10509614
36Asymmetry of the thorax (HP:0001555)3.10379635
37Squamous cell carcinoma (HP:0002860)3.09814930
38Basal cell carcinoma (HP:0002671)3.04370430
39Aplasia/Hypoplasia of the patella (HP:0006498)3.01152806
40Volvulus (HP:0002580)2.94971142
41Male infertility (HP:0003251)2.91816549
42Abnormality of male internal genitalia (HP:0000022)2.86391750
43Achilles tendon contracture (HP:0001771)2.85970659
44Broad distal phalanx of finger (HP:0009836)2.85439425
45Abnormality of the labia minora (HP:0012880)2.74999840
46Broad alveolar ridges (HP:0000187)2.73105369
47Premature graying of hair (HP:0002216)2.70549640
48Short chin (HP:0000331)2.67690178
49Alacrima (HP:0000522)2.66740554
50Anteriorly placed anus (HP:0001545)2.66049511
51Congenital hip dislocation (HP:0001374)2.64397480
52Abnormality of the umbilical cord (HP:0010881)2.64187621
53Birth length less than 3rd percentile (HP:0003561)2.60590508
54Abnormality of the aortic arch (HP:0012303)2.59967886
55Abnormality of the fetal cardiovascular system (HP:0010948)2.59937711
56Abnormal umbilical cord blood vessels (HP:0011403)2.59937711
57Single umbilical artery (HP:0001195)2.59937711
58Capillary hemangiomas (HP:0005306)2.54509844
59Hypochromic anemia (HP:0001931)2.52151092
60Insomnia (HP:0100785)2.50920340
61Trismus (HP:0000211)2.49635396
62Microvesicular hepatic steatosis (HP:0001414)2.48160415
63Progressive external ophthalmoplegia (HP:0000590)2.47564021
64Abnormality of the ileum (HP:0001549)2.47116641
65Multiple enchondromatosis (HP:0005701)2.45610631
66Abnormality of the Achilles tendon (HP:0005109)2.45210368
67Hamartoma (HP:0010566)2.44157440
68Abnormal number of incisors (HP:0011064)2.43366647
69Septate vagina (HP:0001153)2.41406906
70Abnormality of cells of the erythroid lineage (HP:0012130)2.39931637
71Deviation of the thumb (HP:0009603)2.39556236
72Proximal placement of thumb (HP:0009623)2.38046094
73Hypoplasia of the radius (HP:0002984)2.36667149
74Abnormality of the astrocytes (HP:0100707)2.36096088
75Astrocytoma (HP:0009592)2.36096088
76Vertebral fusion (HP:0002948)2.34402634
77Pancreatic islet-cell hyperplasia (HP:0004510)2.32465020
78Premature skin wrinkling (HP:0100678)2.32138918
79Acute lymphatic leukemia (HP:0006721)2.31971259
80Gastrointestinal atresia (HP:0002589)2.30350773
81Hypotelorism (HP:0000601)2.28935967
82Albinism (HP:0001022)2.28745398
83Dysautonomia (HP:0002459)2.27996051
84Increased number of teeth (HP:0011069)2.27551936
85Abnormality of the distal phalanges of the toes (HP:0010182)2.27354224
86Short thumb (HP:0009778)2.22762925
87Bifid uvula (HP:0000193)2.22757719
88Rough bone trabeculation (HP:0100670)2.21951286
89Hypotrichosis (HP:0001006)2.21177215
90Long palpebral fissure (HP:0000637)2.20929313
91Ragged-red muscle fibers (HP:0003200)2.20891543
92Deep palmar crease (HP:0006191)2.20196573
93Cutaneous melanoma (HP:0012056)2.19227017
94Abnormal number of erythroid precursors (HP:0012131)2.17136595
95IgA deficiency (HP:0002720)2.16377290
96Unilateral renal agenesis (HP:0000122)2.16094836
97Increased nuchal translucency (HP:0010880)2.15501571
98Short 5th finger (HP:0009237)2.12026435
99Choanal stenosis (HP:0000452)2.11906269
100Breast hypoplasia (HP:0003187)2.10683869
101Diaphragmatic weakness (HP:0009113)2.09309804
102Abnormality of the phalanges of the hallux (HP:0010057)2.08517279
103Neoplasm of the oral cavity (HP:0100649)2.08301315
104Decreased lacrimation (HP:0000633)2.07451850
105Abnormality of the preputium (HP:0100587)2.03010640
106Bowed forearm bones (HP:0003956)2.01907839
107Bowing of the arm (HP:0006488)2.01907839
108Ependymoma (HP:0002888)2.01373163
109Spinal muscular atrophy (HP:0007269)2.00980913
110Overlapping toe (HP:0001845)2.00690406
111Sparse lateral eyebrow (HP:0005338)1.98730503
112Spastic diplegia (HP:0001264)1.97924522
113Rhabdomyosarcoma (HP:0002859)1.94563397
114Large for gestational age (HP:0001520)1.93760313
115Aplasia of the musculature (HP:0100854)1.93576266
116Cerebral aneurysm (HP:0004944)1.91838466
117Atresia of the external auditory canal (HP:0000413)1.90361855
118Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.89901134
119Microretrognathia (HP:0000308)1.87873179
120Joint stiffness (HP:0001387)1.86857085
121Missing ribs (HP:0000921)1.85792642
122Exertional dyspnea (HP:0002875)1.85415805
123Hypoplasia of the ulna (HP:0003022)1.84987052
124Glioma (HP:0009733)1.84509670
12511 pairs of ribs (HP:0000878)1.83194510
126Hemivertebrae (HP:0002937)1.81788540
127Abnormality of reticulocytes (HP:0004312)1.81735619
128High anterior hairline (HP:0009890)1.81092540
129Nephroblastoma (Wilms tumor) (HP:0002667)1.80790713
130Urinary glycosaminoglycan excretion (HP:0003541)1.80372063
131Mucopolysacchariduria (HP:0008155)1.80372063
132Disproportionate tall stature (HP:0001519)1.79860548
133Split hand (HP:0001171)1.79408031
134Horseshoe kidney (HP:0000085)1.77908811
135Muscle fiber atrophy (HP:0100295)1.76068809
136Overriding aorta (HP:0002623)1.75529602
137Carpal synostosis (HP:0009702)1.75326977
138Patellar dislocation (HP:0002999)1.75205008
139Abnormality of the distal phalanx of the thumb (HP:0009617)1.75037422
140Abnormalities of placenta or umbilical cord (HP:0001194)1.74816394
141Abnormality of chromosome segregation (HP:0002916)1.74266930
142Shawl scrotum (HP:0000049)1.74241770
143Popliteal pterygium (HP:0009756)1.74238359
144Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74053921
145Redundant skin (HP:0001582)1.73634487
146Hypergonadotropic hypogonadism (HP:0000815)1.73208861
147Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72662588
148Reticulocytopenia (HP:0001896)1.72259504
149Elfin facies (HP:0004428)1.72209509
150Cafe-au-lait spot (HP:0000957)1.72094169
151Entropion (HP:0000621)1.70052368
152Glossoptosis (HP:0000162)1.69888905
153Duplication of thumb phalanx (HP:0009942)1.69360550
154Cholecystitis (HP:0001082)1.68860326
155Abnormal gallbladder physiology (HP:0012438)1.68860326
156Renal duplication (HP:0000075)1.68681680
157Secondary amenorrhea (HP:0000869)1.68646227
158Abnormal trabecular bone morphology (HP:0100671)1.67974779
159Hyperparathyroidism (HP:0000843)1.67317060
160Truncus arteriosus (HP:0001660)1.67264652
161Multiple lipomas (HP:0001012)1.67204768
162Nonimmune hydrops fetalis (HP:0001790)1.67204278
163Uterine leiomyosarcoma (HP:0002891)1.66214590
164Leiomyosarcoma (HP:0100243)1.66214590
165Elbow flexion contracture (HP:0002987)1.65587325
166Premature rupture of membranes (HP:0001788)1.62695688
167Premature ovarian failure (HP:0008209)1.60577264
168Micronodular cirrhosis (HP:0001413)1.60151636
169Ankyloglossia (HP:0010296)1.59882656
170Rectal prolapse (HP:0002035)1.58556383
171Slender long bone (HP:0003100)1.58434783
172Abnormality of cochlea (HP:0000375)1.57967505
173Myelodysplasia (HP:0002863)1.56925460
174Dysmetric saccades (HP:0000641)1.55287595
175Vertebral compression fractures (HP:0002953)1.54832937
176Hypertensive crisis (HP:0100735)1.54642664
177Meckel diverticulum (HP:0002245)1.54568008
178Distal lower limb amyotrophy (HP:0008944)1.53493579
179Abnormality of oral frenula (HP:0000190)1.53135056
180Syringomyelia (HP:0003396)1.53107712
181Spinal cord lesions (HP:0100561)1.53107712
182Spinal cord compression (HP:0002176)1.52567032
183Ureteral duplication (HP:0000073)1.52410864
184Abnormality of chromosome stability (HP:0003220)1.52373506
185Urethral obstruction (HP:0000796)1.52173063

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.34719902
2DDR24.54448670
3SMG14.32112539
4MAPK154.29047210
5MAP3K63.95350515
6IRAK33.36704392
7MAP3K113.12384220
8MATK2.70280515
9FGR2.64494699
10TYRO32.56944910
11PINK12.44833425
12PIM22.25885533
13CDK72.21932103
14YES12.21233000
15UHMK12.19474675
16VRK22.18064657
17BMX2.12424680
18DAPK12.03671033
19CSK1.99748542
20PRKD21.94528350
21DYRK1B1.86758661
22PDGFRA1.81088808
23PIM11.77353666
24CDC71.76414795
25MAP3K101.70707164
26TLK11.70647187
27CDK61.60450606
28TRPM71.56871694
29SCYL21.55937993
30WEE11.45610067
31TAF11.43804432
32CHEK21.43446723
33SIK11.43323432
34CDK121.41914651
35PLK11.37899311
36ZAK1.35791199
37TSSK61.33216750
38DYRK31.32045483
39EIF2AK11.30800448
40RPS6KC11.30555563
41RPS6KL11.30555563
42NEK21.28601684
43PBK1.28597054
44AKT31.24374433
45RPS6KB21.22696655
46PKN21.21807660
47BUB11.20233274
48RPS6KA61.14322928
49BRAF1.13810667
50LATS21.13115468
51ATR1.05696721
52MAP2K31.04351952
53MAPK110.96705927
54TTN0.94293842
55GSK3A0.92286615
56CDC42BPA0.89384973
57MST1R0.86031532
58AURKB0.83353973
59BRSK10.82251514
60KDR0.79417705
61ILK0.78989660
62IRAK20.78356563
63ARAF0.75562517
64CDK20.75303553
65SRPK10.72672012
66MTOR0.72468805
67RPS6KA10.71876341
68TTK0.71686842
69MKNK20.71065937
70AURKA0.70683867
71HIPK20.70505146
72CDK40.69694841
73BRD40.67062668
74CHEK10.66865415
75EPHA20.66787078
76IRAK40.63374835
77MAP2K20.63218089
78NME20.63210760
79FGFR40.62943688
80ATM0.62630742
81ERBB30.61371624
82CSNK2A10.59808648
83STK30.59230225
84MKNK10.59060759
85MAP3K90.58720224
86CDK90.58577443
87CLK10.58285679
88PRPF4B0.57465593
89TAOK20.57081502
90DAPK30.54820195
91RPS6KA50.54696348
92RPS6KA40.54635352
93LRRK20.54124830
94BRSK20.53488508
95STK40.53393555
96MAP3K140.53196408
97TESK20.53167643
98PLK30.52751243
99NEK10.51886951
100PASK0.51019976
101STK100.50869583
102PTK60.50403624
103MELK0.50103110
104RAF10.48705011
105PRKAA10.48528031
106CSNK2A20.48001101
107ALK0.47627937
108MAP3K80.46948834
109ACVR1B0.46482537
110PHKG20.45444391
111PHKG10.45444391
112CDK10.45236574
113TAOK10.44534587
114PRKCI0.43064347
115RPS6KB10.41747356
116LYN0.40271489
117CDK80.39415688
118MAPK140.39335111
119ERN10.38947727
120STK160.38777811
121MAPK10.38764584
122KSR20.38680575
123DYRK20.38007650
124PLK40.37675750
125VRK10.36637924
126PAK40.36509080
127PAK20.36364258
128EGFR0.35809171
129CAMK1D0.34364460
130EIF2AK20.33606281
131MAPK30.32654436
132NME10.32302280
133MAP3K130.32233293
134MAPKAPK20.31175635
135PAK10.30793122
136MOS0.30532703
137PDGFRB0.29185224
138CDK11A0.28767558
139LATS10.26713815
140TRIB30.22701339
141MAPK100.22301584
142MAPK40.22242488
143PRKDC0.21985220
144CSNK1G10.21836881
145INSR0.21349697
146EEF2K0.21279763
147AKT20.19627361
148GSK3B0.18521822

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.28119985
2DNA replication_Homo sapiens_hsa030304.79340428
3Base excision repair_Homo sapiens_hsa034104.48740157
4Fatty acid biosynthesis_Homo sapiens_hsa000613.32047960
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.96078739
6Nucleotide excision repair_Homo sapiens_hsa034202.85402406
7* Spliceosome_Homo sapiens_hsa030402.73024600
8Homologous recombination_Homo sapiens_hsa034402.71355862
9Fanconi anemia pathway_Homo sapiens_hsa034602.41869693
10* RNA transport_Homo sapiens_hsa030132.41300331
11Ribosome_Homo sapiens_hsa030102.36756752
12Cell cycle_Homo sapiens_hsa041102.21904866
13* mRNA surveillance pathway_Homo sapiens_hsa030151.92879893
14p53 signaling pathway_Homo sapiens_hsa041151.89616571
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75906424
16Pentose phosphate pathway_Homo sapiens_hsa000301.69846347
17One carbon pool by folate_Homo sapiens_hsa006701.68477809
18Notch signaling pathway_Homo sapiens_hsa043301.67657805
19Hippo signaling pathway_Homo sapiens_hsa043901.58007184
20Hedgehog signaling pathway_Homo sapiens_hsa043401.54802283
21Vitamin B6 metabolism_Homo sapiens_hsa007501.45016372
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.43508010
23Systemic lupus erythematosus_Homo sapiens_hsa053221.42059448
24Non-small cell lung cancer_Homo sapiens_hsa052231.40689435
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39845280
26mTOR signaling pathway_Homo sapiens_hsa041501.39077435
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36540494
28Adherens junction_Homo sapiens_hsa045201.35735097
29Sulfur relay system_Homo sapiens_hsa041221.31338817
30TGF-beta signaling pathway_Homo sapiens_hsa043501.27072029
31RNA polymerase_Homo sapiens_hsa030201.24392160
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21308512
33Bladder cancer_Homo sapiens_hsa052191.17643043
34Basal cell carcinoma_Homo sapiens_hsa052171.16122154
35Viral carcinogenesis_Homo sapiens_hsa052031.13520791
36Arginine and proline metabolism_Homo sapiens_hsa003301.11206987
37RNA degradation_Homo sapiens_hsa030181.09807827
38Basal transcription factors_Homo sapiens_hsa030221.08554201
39Biosynthesis of amino acids_Homo sapiens_hsa012301.03748012
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03245800
41MicroRNAs in cancer_Homo sapiens_hsa052061.03143087
42Circadian rhythm_Homo sapiens_hsa047101.00614897
43Pyrimidine metabolism_Homo sapiens_hsa002401.00313525
44Oocyte meiosis_Homo sapiens_hsa041141.00085041
45Proteasome_Homo sapiens_hsa030500.98951053
46Carbon metabolism_Homo sapiens_hsa012000.97390912
47Shigellosis_Homo sapiens_hsa051310.97125274
48Wnt signaling pathway_Homo sapiens_hsa043100.95474055
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93212033
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92068370
51Non-homologous end-joining_Homo sapiens_hsa034500.91126433
52Colorectal cancer_Homo sapiens_hsa052100.90925675
53N-Glycan biosynthesis_Homo sapiens_hsa005100.90908494
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89724420
55Glioma_Homo sapiens_hsa052140.88113779
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.84790172
57Primary immunodeficiency_Homo sapiens_hsa053400.81705930
58Small cell lung cancer_Homo sapiens_hsa052220.81372284
59Prion diseases_Homo sapiens_hsa050200.79199710
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78056528
61Chronic myeloid leukemia_Homo sapiens_hsa052200.76427349
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76002268
63Thyroid cancer_Homo sapiens_hsa052160.75663769
64Lysine degradation_Homo sapiens_hsa003100.73545582
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73418749
66Epstein-Barr virus infection_Homo sapiens_hsa051690.71690584
67Legionellosis_Homo sapiens_hsa051340.70431939
68Folate biosynthesis_Homo sapiens_hsa007900.69280349
69VEGF signaling pathway_Homo sapiens_hsa043700.68301276
70Other glycan degradation_Homo sapiens_hsa005110.67904554
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.67732713
72Viral myocarditis_Homo sapiens_hsa054160.65779787
73HTLV-I infection_Homo sapiens_hsa051660.63908686
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63239631
75Purine metabolism_Homo sapiens_hsa002300.63129239
76Renal cell carcinoma_Homo sapiens_hsa052110.61273157
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59392716
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.59093353
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.58738651
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58479208
81Tight junction_Homo sapiens_hsa045300.57664813
82Acute myeloid leukemia_Homo sapiens_hsa052210.57573672
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57129052
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54916799
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53886443
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53848689
87* Herpes simplex infection_Homo sapiens_hsa051680.53210996
88Fructose and mannose metabolism_Homo sapiens_hsa000510.53075773
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50502155
90Alcoholism_Homo sapiens_hsa050340.49441032
91Influenza A_Homo sapiens_hsa051640.49118464
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47810752
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47610441
94Insulin signaling pathway_Homo sapiens_hsa049100.44699585
95Hepatitis B_Homo sapiens_hsa051610.44370494
96Vibrio cholerae infection_Homo sapiens_hsa051100.42602132
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42352236
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41202990
99Prostate cancer_Homo sapiens_hsa052150.39411400
100Proteoglycans in cancer_Homo sapiens_hsa052050.38671342
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38188031
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38165492
103Pathways in cancer_Homo sapiens_hsa052000.37967646
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36540100
105Glutathione metabolism_Homo sapiens_hsa004800.34863727
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.34391118
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34340035
108Endometrial cancer_Homo sapiens_hsa052130.34214494
109ErbB signaling pathway_Homo sapiens_hsa040120.33287200
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32841579
111Apoptosis_Homo sapiens_hsa042100.30155986
112Measles_Homo sapiens_hsa051620.28951142
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.28898725
114Galactose metabolism_Homo sapiens_hsa000520.27656981
115AMPK signaling pathway_Homo sapiens_hsa041520.26790561
116Dorso-ventral axis formation_Homo sapiens_hsa043200.25978638
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.25262862
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24965770
119Focal adhesion_Homo sapiens_hsa045100.24224946
120Choline metabolism in cancer_Homo sapiens_hsa052310.23784168
121Selenocompound metabolism_Homo sapiens_hsa004500.23475369
122Pancreatic cancer_Homo sapiens_hsa052120.23245072
123HIF-1 signaling pathway_Homo sapiens_hsa040660.23243709
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22742499
125Melanoma_Homo sapiens_hsa052180.21083868
126Gap junction_Homo sapiens_hsa045400.20927674
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20119109
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19567168
129B cell receptor signaling pathway_Homo sapiens_hsa046620.19045710
130Antigen processing and presentation_Homo sapiens_hsa046120.18965942
131MAPK signaling pathway_Homo sapiens_hsa040100.18693207

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