AMACR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.49319156
2L-phenylalanine catabolic process (GO:0006559)7.49319156
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.26310397
4L-phenylalanine metabolic process (GO:0006558)7.26310397
5aromatic amino acid family catabolic process (GO:0009074)6.79641411
6glyoxylate metabolic process (GO:0046487)6.36564900
7indole-containing compound catabolic process (GO:0042436)6.18491437
8indolalkylamine catabolic process (GO:0046218)6.18491437
9tryptophan catabolic process (GO:0006569)6.18491437
10kynurenine metabolic process (GO:0070189)5.89916583
11cysteine metabolic process (GO:0006534)5.85982489
12tryptophan metabolic process (GO:0006568)5.82812220
13* bile acid biosynthetic process (GO:0006699)5.63734664
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.60023045
15epoxygenase P450 pathway (GO:0019373)5.55162211
16lysine catabolic process (GO:0006554)5.45187237
17lysine metabolic process (GO:0006553)5.45187237
18sulfur amino acid catabolic process (GO:0000098)5.38258764
19serine family amino acid catabolic process (GO:0009071)5.34407115
20alpha-linolenic acid metabolic process (GO:0036109)5.31382420
21urea cycle (GO:0000050)5.25923131
22urea metabolic process (GO:0019627)5.25923131
23negative regulation of fibrinolysis (GO:0051918)5.03523214
24homocysteine metabolic process (GO:0050667)5.01951813
25* fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.00595414
26aromatic amino acid family metabolic process (GO:0009072)4.97967428
27protein carboxylation (GO:0018214)4.88983396
28peptidyl-glutamic acid carboxylation (GO:0017187)4.88983396
29amino-acid betaine metabolic process (GO:0006577)4.88518670
30nitrogen cycle metabolic process (GO:0071941)4.86557895
31high-density lipoprotein particle remodeling (GO:0034375)4.86491401
32complement activation, alternative pathway (GO:0006957)4.84303140
33regulation of fibrinolysis (GO:0051917)4.83743391
34regulation of protein activation cascade (GO:2000257)4.82395487
35drug transmembrane transport (GO:0006855)4.79036491
36omega-hydroxylase P450 pathway (GO:0097267)4.76682793
37alpha-amino acid catabolic process (GO:1901606)4.75058513
38* bile acid metabolic process (GO:0008206)4.71435306
39cellular ketone body metabolic process (GO:0046950)4.67400022
40urate metabolic process (GO:0046415)4.64120406
41tyrosine metabolic process (GO:0006570)4.60661881
42regulation of complement activation (GO:0030449)4.52823384
43serine family amino acid metabolic process (GO:0009069)4.52653708
44drug catabolic process (GO:0042737)4.48191642
45phenylpropanoid metabolic process (GO:0009698)4.46837196
46cellular amino acid catabolic process (GO:0009063)4.46303213
47regulation of triglyceride catabolic process (GO:0010896)4.42992380
48cellular modified amino acid catabolic process (GO:0042219)4.41747336
49indolalkylamine metabolic process (GO:0006586)4.40219805
50glycine metabolic process (GO:0006544)4.37238875
51glutamate metabolic process (GO:0006536)4.33810218
52coenzyme catabolic process (GO:0009109)4.30366961
53cellular glucuronidation (GO:0052695)4.28188749
54acylglycerol homeostasis (GO:0055090)4.27948913
55triglyceride homeostasis (GO:0070328)4.27948913
56reverse cholesterol transport (GO:0043691)4.25377926
57serine family amino acid biosynthetic process (GO:0009070)4.24879511
58short-chain fatty acid metabolic process (GO:0046459)4.24286941
59regulation of cholesterol esterification (GO:0010872)4.23928659
60cellular biogenic amine catabolic process (GO:0042402)4.23050193
61amine catabolic process (GO:0009310)4.23050193
62ethanol metabolic process (GO:0006067)4.20995393
63oxidative demethylation (GO:0070989)4.18689386
64plasma lipoprotein particle remodeling (GO:0034369)4.18676436
65protein-lipid complex remodeling (GO:0034368)4.18676436
66macromolecular complex remodeling (GO:0034367)4.18676436
67benzene-containing compound metabolic process (GO:0042537)4.16639799
68negative regulation of cholesterol transport (GO:0032375)4.15053068
69negative regulation of sterol transport (GO:0032372)4.15053068
70imidazole-containing compound metabolic process (GO:0052803)4.14133315
71exogenous drug catabolic process (GO:0042738)4.12041001
72aldehyde catabolic process (GO:0046185)4.09665409
73ketone body metabolic process (GO:1902224)4.05071772
74ethanol oxidation (GO:0006069)4.03912074
75aspartate family amino acid catabolic process (GO:0009068)4.02870991
76bile acid and bile salt transport (GO:0015721)4.01026514
77dicarboxylic acid biosynthetic process (GO:0043650)3.99155608
78acetyl-CoA metabolic process (GO:0006084)3.96422256
79* carboxylic acid catabolic process (GO:0046395)3.95632473
80* organic acid catabolic process (GO:0016054)3.95632473
81phospholipid efflux (GO:0033700)3.93762955
82drug transport (GO:0015893)3.92836564
83glucuronate metabolic process (GO:0019585)3.92539509
84uronic acid metabolic process (GO:0006063)3.92539509
85arginine metabolic process (GO:0006525)3.89314222
86plasma lipoprotein particle clearance (GO:0034381)3.88829254
87biotin metabolic process (GO:0006768)3.86202207
882-oxoglutarate metabolic process (GO:0006103)3.82225767
89* fatty acid beta-oxidation (GO:0006635)3.80159606
90* fatty acid oxidation (GO:0019395)3.74412605
91carnitine metabolic process (GO:0009437)3.72360314
92* monocarboxylic acid catabolic process (GO:0072329)3.70439438
93regulation of plasminogen activation (GO:0010755)3.67813048
94* lipid oxidation (GO:0034440)3.67075166
95regulation of bile acid biosynthetic process (GO:0070857)3.67035715
96blood coagulation, intrinsic pathway (GO:0007597)3.66830836
97regulation of cholesterol homeostasis (GO:2000188)3.62633659
98fibrinolysis (GO:0042730)3.62335145
99cholesterol efflux (GO:0033344)3.61165219
100* fatty acid catabolic process (GO:0009062)3.60403817
101cofactor catabolic process (GO:0051187)3.57621448
102flavonoid metabolic process (GO:0009812)3.55040549
103drug metabolic process (GO:0017144)3.53562360
104pyridine nucleotide biosynthetic process (GO:0019363)3.49997428
105nicotinamide nucleotide biosynthetic process (GO:0019359)3.49997428
106cholesterol homeostasis (GO:0042632)3.49048555
107valine metabolic process (GO:0006573)3.48230651
108NAD biosynthetic process (GO:0009435)3.47399944
109branched-chain amino acid catabolic process (GO:0009083)3.47107967
110very-low-density lipoprotein particle assembly (GO:0034379)3.42691681
111iron ion import (GO:0097286)3.28480452
112S-adenosylmethionine metabolic process (GO:0046500)3.28307696
113amino acid salvage (GO:0043102)3.22627273
114L-methionine salvage (GO:0071267)3.22627273
115L-methionine biosynthetic process (GO:0071265)3.22627273
116alkaloid metabolic process (GO:0009820)3.13937439
117primary alcohol metabolic process (GO:0034308)2.99745536
118phosphate ion transmembrane transport (GO:0035435)2.95191812
119fructose metabolic process (GO:0006000)2.93858109
120xenobiotic metabolic process (GO:0006805)2.92122435
121primary alcohol catabolic process (GO:0034310)2.91386724
122phosphate ion transport (GO:0006817)2.88812072
123branched-chain amino acid metabolic process (GO:0009081)2.85575950
124fat-soluble vitamin biosynthetic process (GO:0042362)2.83559508
125heme transport (GO:0015886)2.82159599
126positive regulation of cellular amine metabolic process (GO:0033240)2.81350290
127negative regulation of protein activation cascade (GO:2000258)2.80923338
128regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.80792118
129negative regulation of lipase activity (GO:0060192)2.80691471
130vitamin biosynthetic process (GO:0009110)2.76551645
131aminoglycoside antibiotic metabolic process (GO:0030647)2.75117158
132protein autoprocessing (GO:0016540)2.74907302
133polyketide metabolic process (GO:0030638)2.74320276
134doxorubicin metabolic process (GO:0044598)2.74320276
135daunorubicin metabolic process (GO:0044597)2.74320276
136cellular aldehyde metabolic process (GO:0006081)2.73308579
137negative regulation of fatty acid metabolic process (GO:0045922)2.72150200
138water-soluble vitamin biosynthetic process (GO:0042364)2.69543783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.28279111
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.14897755
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.66661333
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.34725948
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.27241305
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.03679767
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.80303532
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.95943358
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.89966620
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.16780945
11PIAS1_25552417_ChIP-Seq_VCAP_Human2.83215324
12AR_21909140_ChIP-Seq_LNCAP_Human2.66784377
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39401848
14IGF1R_20145208_ChIP-Seq_DFB_Human2.22749060
15* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18261615
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09534368
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7223924
18HIF1A_21447827_ChIP-Seq_MCF-7_Human1.93995975
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.83805320
20CLOCK_20551151_ChIP-Seq_293T_Human1.72721620
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61321936
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.54652858
23* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52700244
24* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45872944
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42598209
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39914125
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38122009
28GATA1_22025678_ChIP-Seq_K562_Human1.38000475
29* CHD1_26751641_Chip-Seq_LNCaP_Human1.36655528
30HTT_18923047_ChIP-ChIP_STHdh_Human1.27396531
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27299460
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26729496
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22194009
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22179732
35RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19855959
36EOMES_21245162_ChIP-Seq_HESCs_Human1.17300930
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13551588
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11809708
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10419834
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10127083
41IRF1_19129219_ChIP-ChIP_H3396_Human1.04812746
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04660796
43TAF15_26573619_Chip-Seq_HEK293_Human1.03370790
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.01958732
45FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00695212
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00443337
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99143194
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98102074
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93884335
50TRIM28_21343339_ChIP-Seq_HEK293_Human0.93160154
51POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90799158
52CBX2_27304074_Chip-Seq_ESCs_Mouse0.89087216
53GATA4_25053715_ChIP-Seq_YYC3_Human0.88856905
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88742902
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87447495
56AR_21572438_ChIP-Seq_LNCaP_Human0.86998590
57* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86814417
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86420008
59VDR_22108803_ChIP-Seq_LS180_Human0.86156966
60ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86048183
61SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85929792
62ESR1_21235772_ChIP-Seq_MCF-7_Human0.85888737
63AR_25329375_ChIP-Seq_VCAP_Human0.84341303
64AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82200258
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81951267
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79954457
67* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79855376
68ESR2_21235772_ChIP-Seq_MCF-7_Human0.79732309
69BMI1_23680149_ChIP-Seq_NPCS_Mouse0.78165062
70ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77361956
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77176668
72KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77032508
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74671328
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74610151
75SRF_21415370_ChIP-Seq_HL-1_Mouse0.73913729
76RARA_24833708_ChIP-Seq_LIVER_Mouse0.72507871
77ZNF263_19887448_ChIP-Seq_K562_Human0.72320117
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.71434458
79SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71036153
80CDX2_22108803_ChIP-Seq_LS180_Human0.70730221
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.70161670
82TAL1_26923725_Chip-Seq_HPCs_Mouse0.69742932
83SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.69662444
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68916066
85* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68783245
86* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.68418821
87SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67649059
88BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66573253
89* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66027017
90NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.65854203
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65624061
92LXR_22292898_ChIP-Seq_THP-1_Human0.64783797
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.64551287
94RARB_24833708_ChIP-Seq_LIVER_Mouse0.64392884
95IRF8_22096565_ChIP-ChIP_GC-B_Human0.64218819
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.63840572
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62551846
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62347569
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62347569
100CEBPB_22108803_ChIP-Seq_LS180_Human0.61928460
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.60936515
102FOXA1_25329375_ChIP-Seq_VCAP_Human0.60413876
103FOXA1_27270436_Chip-Seq_PROSTATE_Human0.60413876
104AR_20517297_ChIP-Seq_VCAP_Human0.60386617
105EGR1_19032775_ChIP-ChIP_M12_Human0.60380709
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.59595895
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.58590136
108* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57744149
109* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.57735665
110TCF4_18268006_ChIP-ChIP_LS174T_Human0.57286298
111TCF4_22108803_ChIP-Seq_LS180_Human0.56932333
112ZFP57_27257070_Chip-Seq_ESCs_Mouse0.56494682
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56070194
114MYC_19915707_ChIP-ChIP_AK7_Human0.54379532
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.53750765
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.53709984
117ESET_19884257_ChIP-Seq_ESCs_Mouse0.52066545
118CBP_21632823_ChIP-Seq_H3396_Human0.51748371
119* CDX2_20551321_ChIP-Seq_CACO-2_Human0.51569452
120* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51503881
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.50336020
122TAF2_19829295_ChIP-Seq_ESCs_Human0.49905182
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.49666804
124PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49564754
125GATA6_25053715_ChIP-Seq_YYC3_Human0.49537889
126STAT1_17558387_ChIP-Seq_HELA_Human0.48156733
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47607231
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47210019
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.46824442
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45834088
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.45101907
132* P53_21459846_ChIP-Seq_SAOS-2_Human0.44083036
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43138070
134PPAR_26484153_Chip-Seq_NCI-H1993_Human0.43114151
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.42598370
136TET1_21451524_ChIP-Seq_MESCs_Mouse0.40613999
137TBX20_22080862_ChIP-Seq_HEART_Mouse0.40519901
138TBX20_22328084_ChIP-Seq_HEART_Mouse0.40519901
139ERG_20517297_ChIP-Seq_VCAP_Human0.40285653
140CSB_26484114_Chip-Seq_FIBROBLAST_Human0.39810020
141CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.39449413
142FOXH1_21741376_ChIP-Seq_EPCs_Human0.39315269
143GATA3_24758297_ChIP-Seq_MCF-7_Human0.39128689
144RACK7_27058665_Chip-Seq_MCF-7_Human0.39079401
145BCAT_22108803_ChIP-Seq_LS180_Human0.38835592
146GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.38370226
147* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.38139445
148SOX2_20726797_ChIP-Seq_SW620_Human0.37990986
149LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.37892881
150GATA1_19941827_ChIP-Seq_MEL_Mouse0.37606373
151GATA2_19941826_ChIP-Seq_K562_Human0.37325932
152SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.37281240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.18123847
2MP0005360_urolithiasis7.96801981
3* MP0005085_abnormal_gallbladder_physiolo5.96156622
4MP0005365_abnormal_bile_salt5.88234602
5MP0008875_abnormal_xenobiotic_pharmacok4.98720380
6MP0003806_abnormal_nucleotide_metabolis4.33080953
7MP0003252_abnormal_bile_duct3.92285323
8MP0010329_abnormal_lipoprotein_level3.27975463
9MP0005332_abnormal_amino_acid3.27039799
10MP0003195_calcinosis3.10107982
11MP0010234_abnormal_vibrissa_follicle2.93682326
12MP0005083_abnormal_biliary_tract2.82882135
13MP0009840_abnormal_foam_cell2.79460277
14MP0003123_paternal_imprinting2.70590919
15MP0004019_abnormal_vitamin_homeostasis2.63958397
16MP0001666_abnormal_nutrient_absorption2.45162952
17MP0002909_abnormal_adrenal_gland2.44929669
18MP0002138_abnormal_hepatobiliary_system2.32193667
19MP0003191_abnormal_cellular_cholesterol2.10546302
20MP0000609_abnormal_liver_physiology2.03213530
21* MP0002118_abnormal_lipid_homeostasis2.00456212
22* MP0005319_abnormal_enzyme/_coenzyme1.86638885
23MP0001764_abnormal_homeostasis1.77548432
24MP0009643_abnormal_urine_homeostasis1.70381064
25MP0003868_abnormal_feces_composition1.68823862
26MP0005584_abnormal_enzyme/coenzyme_acti1.66637401
27MP0003879_abnormal_hair_cell1.56592822
28MP0003186_abnormal_redox_activity1.51286935
29MP0005451_abnormal_body_composition1.43841263
30MP0004858_abnormal_nervous_system1.38887362
31MP0003011_delayed_dark_adaptation1.36967298
32MP0001188_hyperpigmentation1.33443932
33MP0003283_abnormal_digestive_organ1.33300981
34MP0005636_abnormal_mineral_homeostasis1.30635199
35MP0009697_abnormal_copulation1.30050717
36MP0003315_abnormal_perineum_morphology1.28591899
37MP0002234_abnormal_pharynx_morphology1.22199261
38MP0002090_abnormal_vision1.18244042
39MP0004145_abnormal_muscle_electrophysio1.13040956
40MP0006036_abnormal_mitochondrial_physio1.12640986
41MP0005187_abnormal_penis_morphology1.11361949
42* MP0000598_abnormal_liver_morphology1.10957668
43MP0009780_abnormal_chondrocyte_physiolo1.10630423
44MP0003705_abnormal_hypodermis_morpholog1.09410336
45MP0003656_abnormal_erythrocyte_physiolo1.08440264
46MP0003122_maternal_imprinting1.07260328
47MP0004043_abnormal_pH_regulation1.06134379
48MP0005647_abnormal_sex_gland1.05641721
49MP0005670_abnormal_white_adipose1.04627452
50MP0005084_abnormal_gallbladder_morpholo1.03784390
51MP0005409_darkened_coat_color1.00605627
52MP0009764_decreased_sensitivity_to0.99500594
53MP0001756_abnormal_urination0.96346357
54MP0004270_analgesia0.95868149
55MP0005248_abnormal_Harderian_gland0.92762003
56MP0005646_abnormal_pituitary_gland0.91591166
57MP0002160_abnormal_reproductive_system0.91185768
58MP0002876_abnormal_thyroid_physiology0.91135427
59MP0000537_abnormal_urethra_morphology0.91097321
60MP0010386_abnormal_urinary_bladder0.89300952
61* MP0009642_abnormal_blood_homeostasis0.88497633
62MP0005551_abnormal_eye_electrophysiolog0.86513812
63MP0002938_white_spotting0.83947779
64* MP0009763_increased_sensitivity_to0.83720585
65MP0005645_abnormal_hypothalamus_physiol0.83429674
66* MP0008469_abnormal_protein_level0.82178084
67MP0000604_amyloidosis0.82119213
68MP0002078_abnormal_glucose_homeostasis0.81406496
69MP0005408_hypopigmentation0.81173560
70MP0005376_homeostasis/metabolism_phenot0.80667452
71MP0002136_abnormal_kidney_physiology0.80060584
72MP0010368_abnormal_lymphatic_system0.79520745
73MP0005220_abnormal_exocrine_pancreas0.79233808
74MP0002557_abnormal_social/conspecific_i0.78646487
75MP0005535_abnormal_body_temperature0.77998165
76MP0002837_dystrophic_cardiac_calcinosis0.77470244
77MP0009379_abnormal_foot_pigmentation0.76975882
78MP0002971_abnormal_brown_adipose0.76274093
79MP0006035_abnormal_mitochondrial_morpho0.74109457
80MP0002254_reproductive_system_inflammat0.73128758
81MP0005266_abnormal_metabolism0.71451520
82MP0004130_abnormal_muscle_cell0.71378648
83MP0004233_abnormal_muscle_weight0.70753926
84MP0001661_extended_life_span0.70520106
85MP0001765_abnormal_ion_homeostasis0.67594644
86MP0009765_abnormal_xenobiotic_induced0.66984950
87MP0002166_altered_tumor_susceptibility0.65830708
88MP0005334_abnormal_fat_pad0.65411845
89MP0000003_abnormal_adipose_tissue0.65235559
90MP0002928_abnormal_bile_duct0.64424591
91MP0002653_abnormal_ependyma_morphology0.63374330
92MP0006072_abnormal_retinal_apoptosis0.63214694
93MP0005379_endocrine/exocrine_gland_phen0.62709392
94MP0008789_abnormal_olfactory_epithelium0.62336460
95MP0003121_genomic_imprinting0.62263671
96MP0000516_abnormal_urinary_system0.59908317
97MP0005367_renal/urinary_system_phenotyp0.59908317
98MP0009053_abnormal_anal_canal0.57847249
99MP0005666_abnormal_adipose_tissue0.57119511
100MP0000372_irregular_coat_pigmentation0.55838867
101MP0000013_abnormal_adipose_tissue0.55195156
102MP0001324_abnormal_eye_pigmentation0.53425011
103MP0005395_other_phenotype0.52519185
104MP0005386_behavior/neurological_phenoty0.51691070
105MP0004924_abnormal_behavior0.51691070
106MP0001905_abnormal_dopamine_level0.51479584
107MP0003638_abnormal_response/metabolism_0.51222934
108MP0000230_abnormal_systemic_arterial0.50561897
109MP0000462_abnormal_digestive_system0.49855064
110MP0005058_abnormal_lysosome_morphology0.49606672
111MP0003890_abnormal_embryonic-extraembry0.48932886
112MP0000747_muscle_weakness0.48697497
113MP0003329_amyloid_beta_deposits0.47740900
114MP0003690_abnormal_glial_cell0.47377401
115MP0000639_abnormal_adrenal_gland0.47220349
116MP0005499_abnormal_olfactory_system0.46611674
117MP0005394_taste/olfaction_phenotype0.46611674
118MP0005448_abnormal_energy_balance0.46410183
119MP0003953_abnormal_hormone_level0.45161209
120MP0002168_other_aberrant_phenotype0.43537357
121MP0003718_maternal_effect0.40094545
122MP0008874_decreased_physiological_sensi0.39614914
123MP0009384_cardiac_valve_regurgitation0.39605624
124MP0009672_abnormal_birth_weight0.37477090
125MP0002796_impaired_skin_barrier0.37244125
126MP0003724_increased_susceptibility_to0.36362714
127MP0008873_increased_physiological_sensi0.35887772
128MP0009115_abnormal_fat_cell0.34999158
129MP0002135_abnormal_kidney_morphology0.34448518
130MP0003959_abnormal_lean_body0.33800406
131MP0004782_abnormal_surfactant_physiolog0.33126429
132MP0002269_muscular_atrophy0.32327416
133MP0002822_catalepsy0.31628223
134MP0005166_decreased_susceptibility_to0.31442677
135MP0000538_abnormal_urinary_bladder0.31404599
136MP0002970_abnormal_white_adipose0.30434790
137MP0008872_abnormal_physiological_respon0.30067302
138MP0004147_increased_porphyrin_level0.29271662
139MP0005330_cardiomyopathy0.28122461
140MP0000579_abnormal_nail_morphology0.27832353
141MP0005464_abnormal_platelet_physiology0.27403635
142MP0003075_altered_response_to0.27260844
143MP0001944_abnormal_pancreas_morphology0.24465666
144MP0005595_abnormal_vascular_smooth0.24164421
145MP0004264_abnormal_extraembryonic_tissu0.22691198
146MP0000249_abnormal_blood_vessel0.22607856
147MP0001845_abnormal_inflammatory_respons0.21725116

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.05892092
2* Intrahepatic cholestasis (HP:0001406)6.45568037
3Deep venous thrombosis (HP:0002625)6.41017202
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.06152561
5Xanthomatosis (HP:0000991)5.86843008
6Prolonged partial thromboplastin time (HP:0003645)5.62307816
7Hypobetalipoproteinemia (HP:0003563)5.56658364
8Hyperlipoproteinemia (HP:0010980)4.80058575
9Hyperglycinuria (HP:0003108)4.78266256
10Hyperammonemia (HP:0001987)4.78171207
11Ketosis (HP:0001946)4.75482638
12Complement deficiency (HP:0004431)4.67964237
13Hyperglycinemia (HP:0002154)4.67829564
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.66072568
15Abnormality of serine family amino acid metabolism (HP:0010894)4.52955358
16Abnormality of glycine metabolism (HP:0010895)4.52955358
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.28036665
18Hypolipoproteinemia (HP:0010981)4.23929080
19Joint hemorrhage (HP:0005261)4.23393373
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.20088410
21Hypoglycemic coma (HP:0001325)4.05008811
22Epidermoid cyst (HP:0200040)3.98733922
23Hyperactive renin-angiotensin system (HP:0000841)3.98465598
24Abnormality of methionine metabolism (HP:0010901)3.91341196
25Ketoacidosis (HP:0001993)3.87326138
26Abnormality of the common coagulation pathway (HP:0010990)3.86710173
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.84643213
28Abnormality of fatty-acid metabolism (HP:0004359)3.83456086
29Hypoalphalipoproteinemia (HP:0003233)3.76304223
30Gout (HP:0001997)3.71473957
31Abnormality of pyrimidine metabolism (HP:0004353)3.54857548
32* Fat malabsorption (HP:0002630)3.50806839
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.49637512
34Abnormality of nucleobase metabolism (HP:0010932)3.45845558
35Delayed CNS myelination (HP:0002188)3.41647146
36Abnormality of purine metabolism (HP:0004352)3.41339563
37Abnormality of complement system (HP:0005339)3.37044098
38Abnormality of the intrinsic pathway (HP:0010989)3.34522334
39Conjugated hyperbilirubinemia (HP:0002908)3.30900853
40Abnormality of serum amino acid levels (HP:0003112)3.23356312
41Abnormality of dicarboxylic acid metabolism (HP:0010995)3.12455916
42Dicarboxylic aciduria (HP:0003215)3.12455916
43Hypercholesterolemia (HP:0003124)3.11190724
44Metabolic acidosis (HP:0001942)3.10614185
45Generalized aminoaciduria (HP:0002909)3.02027465
46Decreased circulating renin level (HP:0003351)2.98630083
47Lethargy (HP:0001254)2.98093952
48* Hyperbilirubinemia (HP:0002904)2.96376649
49Hepatocellular carcinoma (HP:0001402)2.95110971
50Proximal tubulopathy (HP:0000114)2.87646922
51Vascular calcification (HP:0004934)2.84612753
52Steatorrhea (HP:0002570)2.83804557
53Cerebral edema (HP:0002181)2.75592241
54Abnormality of renin-angiotensin system (HP:0000847)2.71327747
55Hyperphosphaturia (HP:0003109)2.63258244
56Increased purine levels (HP:0004368)2.58322231
57Hyperuricemia (HP:0002149)2.58322231
58Malnutrition (HP:0004395)2.57396952
59Increased serum pyruvate (HP:0003542)2.54475998
60Skin nodule (HP:0200036)2.54210407
61Cardiovascular calcification (HP:0011915)2.54058899
62Myocardial infarction (HP:0001658)2.52791223
63Abnormal urine phosphate concentration (HP:0012599)2.51574684
64Abnormal tarsal ossification (HP:0008369)2.50199014
65Alkalosis (HP:0001948)2.50055115
66Irritability (HP:0000737)2.48976047
67Spontaneous abortion (HP:0005268)2.47709304
68Abnormality of glycolysis (HP:0004366)2.47003535
69Systemic lupus erythematosus (HP:0002725)2.46971808
70Vomiting (HP:0002013)2.45855599
71Hypoglycemic seizures (HP:0002173)2.45108690
72Hypokalemia (HP:0002900)2.41603215
73Abnormality of urine glucose concentration (HP:0011016)2.41588517
74Glycosuria (HP:0003076)2.41588517
75Spastic diplegia (HP:0001264)2.41482858
76Late onset (HP:0003584)2.40895377
77Osteomalacia (HP:0002749)2.39753689
78Enlarged kidneys (HP:0000105)2.38512564
79Hydroxyprolinuria (HP:0003080)2.33075265
80Abnormality of proline metabolism (HP:0010907)2.33075265
81Hyperaldosteronism (HP:0000859)2.30442387
82Hypochromic microcytic anemia (HP:0004840)2.29861106
83Abnormal gallbladder morphology (HP:0012437)2.25398945
84Rickets (HP:0002748)2.25394084
85Amelogenesis imperfecta (HP:0000705)2.22159605
86Pancreatitis (HP:0001733)2.21810428
87Cholelithiasis (HP:0001081)2.21639121
88Metabolic alkalosis (HP:0200114)2.18138684
89Mitral stenosis (HP:0001718)2.17608911
90* Neonatal onset (HP:0003623)2.14996563
91Abnormal enzyme/coenzyme activity (HP:0012379)2.13100716
92Abnormality of chloride homeostasis (HP:0011422)2.10367977
93Cholecystitis (HP:0001082)2.09554154
94Abnormal gallbladder physiology (HP:0012438)2.09554154
95Acute encephalopathy (HP:0006846)2.07663191
96Abnormality of magnesium homeostasis (HP:0004921)2.06581378
97Reduced antithrombin III activity (HP:0001976)2.05791312
98Hyperinsulinemic hypoglycemia (HP:0000825)2.05037241
99Brushfield spots (HP:0001088)2.04654865
100Flat acetabular roof (HP:0003180)2.04192882
101Opisthotonus (HP:0002179)2.00942949
102Abnormality of potassium homeostasis (HP:0011042)2.00831860
103Acanthocytosis (HP:0001927)1.99769802
104Glomerulonephritis (HP:0000099)1.98269568
105Renal cortical cysts (HP:0000803)1.96159646
106Nausea (HP:0002018)1.95780573
107Abnormal cartilage morphology (HP:0002763)1.95451122
108Hypomagnesemia (HP:0002917)1.93666351
109Esophageal varix (HP:0002040)1.91350698
110Hyperphosphatemia (HP:0002905)1.90686764
111Abnormality of alkaline phosphatase activity (HP:0004379)1.89593898
112Nephrolithiasis (HP:0000787)1.88290455
113Hypophosphatemic rickets (HP:0004912)1.87833424
114Confusion (HP:0001289)1.85574944
115Amyloidosis (HP:0011034)1.84849172
116Renal salt wasting (HP:0000127)1.84565696
117Renal tubular dysfunction (HP:0000124)1.84347569
118Thrombophlebitis (HP:0004418)1.84273382
119Abnormality of vitamin metabolism (HP:0100508)1.84096502
120Rhabdomyolysis (HP:0003201)1.83837819
121Recurrent gram-negative bacterial infections (HP:0005420)1.83585403
122Abnormality of carpal bone ossification (HP:0006257)1.83455145
123Elevated alkaline phosphatase (HP:0003155)1.82975648
124Hypothermia (HP:0002045)1.82895904
125Increased circulating renin level (HP:0000848)1.82779516
126Chronic bronchitis (HP:0004469)1.81385311
127Menorrhagia (HP:0000132)1.80272748
128Abnormality of transition element cation homeostasis (HP:0011030)1.79473008
129Neonatal hypoglycemia (HP:0001998)1.79029619
130Hyperglycemia (HP:0003074)1.77174946
131Myoglobinuria (HP:0002913)1.77080947
132Hypoplasia of the uterus (HP:0000013)1.72409756
133Hyperkalemia (HP:0002153)1.69822824
134* Sensorimotor neuropathy (HP:0007141)1.65937894
135Nephrogenic diabetes insipidus (HP:0009806)1.65236411
136Bifid scrotum (HP:0000048)1.64190570
137Symptomatic seizures (HP:0011145)1.62853121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.87949063
2AKT34.03846370
3FGFR44.02912972
4ERN14.00279048
5STK163.79876834
6SIK13.67477719
7PRKD33.07066137
8INSRR2.78407530
9TAOK12.73797986
10WNK42.53530440
11ERBB42.51885227
12STK38L2.45054983
13TAOK32.23888971
14EPHA22.10908145
15MST1R2.10052475
16FER2.06359918
17PIK3CG2.05748322
18TESK12.04780091
19PKN22.03493097
20CAMK1G1.94920556
21WNK31.93050403
22MAPK111.90617611
23TRIB31.89767258
24FLT31.84833932
25MAP2K41.82962682
26LMTK21.76060101
27BCR1.74304058
28PHKG21.68844134
29PHKG11.68844134
30CASK1.65326882
31PIK3CA1.63635500
32LATS11.44129393
33BRSK21.42808575
34PINK11.42189339
35ERBB31.41612554
36ARAF1.40841732
37OXSR11.40510289
38NEK91.39131591
39ABL21.38345683
40TNK21.36532816
41PTK61.29288303
42PDK41.28845178
43PDK31.28845178
44DYRK31.26939862
45MAP3K71.25891948
46ACVR1B1.24249644
47EEF2K1.23428251
48MAPKAPK31.21467957
49TYK21.20520293
50PRKAA21.19033366
51MAP3K31.18566519
52LIMK11.12696880
53KDR1.11952458
54CSNK1A1L1.09468809
55FRK1.08076944
56MAP2K31.06660128
57GRK61.06302264
58CSNK1G31.06255090
59PRKD21.06192215
60NEK11.06171259
61MAP3K121.05547737
62MAP2K71.04644276
63CAMKK21.03054159
64PIM21.00363844
65NTRK31.00291391
66MAPK150.99334834
67JAK20.98564585
68DAPK20.92341511
69TIE10.91581782
70PRKCI0.90243121
71CSNK1G20.89467439
72EPHA40.88091429
73MAP3K20.87923294
74MET0.86736893
75MAP3K110.84732770
76MAP4K20.83559434
77MAP3K40.82653981
78MAPK40.82622391
79DYRK1B0.80726016
80PRKAA10.80015942
81PRKCZ0.78788857
82TBK10.78319168
83MAPK120.77602964
84GSK3A0.76314082
85EPHB10.74968884
86BRSK10.73498430
87PRKACG0.72624049
88SGK4940.72039503
89SGK2230.72039503
90ERBB20.70392421
91BMPR1B0.69932067
92IRAK30.69245907
93SCYL20.67900952
94PTK20.66836696
95MAP3K140.66706121
96MAP3K100.66217655
97FGFR20.64426715
98TAF10.64128366
99PDK20.63540140
100CAMK2G0.63176891
101JAK10.62753644
102SGK30.61736601
103TGFBR20.58490587
104MINK10.56911939
105MAPK130.55975944
106GRK10.55962269
107MAP2K60.54909615
108SGK20.54886737
109EPHB20.54786398
110PDPK10.53868138
111SRPK10.53248873
112OBSCN0.50617541
113CDK60.50344624
114PBK0.50296323
115CSNK1A10.49752600
116PRKCH0.48739299
117MST40.48183488
118TRIM280.47467818
119VRK20.45979782
120SGK10.45916647
121NUAK10.45796597
122PRKCE0.45490034
123MAPK70.45075228
124MYLK0.43926419
125PAK30.43429118
126AKT20.42890211
127MAPKAPK50.42360842
128EIF2AK10.41916279
129STK390.41036746
130STK380.40779562
131LATS20.40527651
132CSNK1E0.40219693
133MAP2K10.39887295
134DMPK0.39710176
135MAP3K60.38647264
136CSNK1G10.38126134
137CAMK1D0.37156766
138PRKCQ0.37153650
139MAP3K50.36724608
140CAMK2D0.36540824
141CDK40.36459314
142CSK0.35445561
143EPHA30.34412278
144IGF1R0.32030222
145TAOK20.31505853
146IRAK10.31426498
147MTOR0.29838899
148PDK10.29725700
149PRKCG0.29347739
150NME20.28961453
151CAMK40.27103559
152IRAK20.27086446
153ICK0.26630048
154PRKCA0.26284463
155RET0.23406072
156PRKACA0.22234501
157LRRK20.21625082
158CSF1R0.21559502
159RIPK10.21290501
160FGFR30.20621236

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001204.07554321
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40761439
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28448454
4Nitrogen metabolism_Homo sapiens_hsa009103.14865875
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.86283274
6Arginine biosynthesis_Homo sapiens_hsa002202.84604049
7Tryptophan metabolism_Homo sapiens_hsa003802.73489380
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.68311690
9Fatty acid degradation_Homo sapiens_hsa000712.64680338
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56013245
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53866945
12Butanoate metabolism_Homo sapiens_hsa006502.50595365
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40710067
14Complement and coagulation cascades_Homo sapiens_hsa046102.36428443
15Propanoate metabolism_Homo sapiens_hsa006402.27510788
16* Peroxisome_Homo sapiens_hsa041462.21319422
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99083385
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97340058
19Fatty acid metabolism_Homo sapiens_hsa012121.91999332
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83945857
21PPAR signaling pathway_Homo sapiens_hsa033201.82365729
22Histidine metabolism_Homo sapiens_hsa003401.81719712
23beta-Alanine metabolism_Homo sapiens_hsa004101.78384123
24Chemical carcinogenesis_Homo sapiens_hsa052041.77983929
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.77640879
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75499646
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.68171666
28Pyruvate metabolism_Homo sapiens_hsa006201.66757932
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65839161
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63668559
31Retinol metabolism_Homo sapiens_hsa008301.57842136
32Selenocompound metabolism_Homo sapiens_hsa004501.56468481
33Phenylalanine metabolism_Homo sapiens_hsa003601.50587516
34Sulfur metabolism_Homo sapiens_hsa009201.49501300
35Bile secretion_Homo sapiens_hsa049761.48831775
36Caffeine metabolism_Homo sapiens_hsa002321.43990220
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.42487217
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40986590
39Staphylococcus aureus infection_Homo sapiens_hsa051501.35609506
40Starch and sucrose metabolism_Homo sapiens_hsa005001.35252243
41Carbon metabolism_Homo sapiens_hsa012001.33938747
42Tyrosine metabolism_Homo sapiens_hsa003501.33932442
43Fatty acid elongation_Homo sapiens_hsa000621.33153380
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.30221586
45Folate biosynthesis_Homo sapiens_hsa007901.29661443
46Biosynthesis of amino acids_Homo sapiens_hsa012301.25491283
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16068783
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15782584
49Arginine and proline metabolism_Homo sapiens_hsa003301.13133851
50ABC transporters_Homo sapiens_hsa020101.06818947
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.05399413
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05017382
53Steroid biosynthesis_Homo sapiens_hsa001001.04059883
54Fat digestion and absorption_Homo sapiens_hsa049751.02014506
55Vitamin digestion and absorption_Homo sapiens_hsa049770.97961509
56Sulfur relay system_Homo sapiens_hsa041220.93306284
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92796384
58Lysine degradation_Homo sapiens_hsa003100.87516308
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85691974
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85614777
61Glutathione metabolism_Homo sapiens_hsa004800.84528913
62Protein export_Homo sapiens_hsa030600.82719476
63Vitamin B6 metabolism_Homo sapiens_hsa007500.81031559
64One carbon pool by folate_Homo sapiens_hsa006700.71658968
65Glycerolipid metabolism_Homo sapiens_hsa005610.71482416
66Pentose phosphate pathway_Homo sapiens_hsa000300.61033791
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57006687
68* Metabolic pathways_Homo sapiens_hsa011000.52738730
69Fatty acid biosynthesis_Homo sapiens_hsa000610.38723929
70Fructose and mannose metabolism_Homo sapiens_hsa000510.38560988
71Insulin secretion_Homo sapiens_hsa049110.37910618
72Galactose metabolism_Homo sapiens_hsa000520.34402341
73Huntingtons disease_Homo sapiens_hsa050160.31403452
74Vibrio cholerae infection_Homo sapiens_hsa051100.29317011
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29088699
76Sphingolipid metabolism_Homo sapiens_hsa006000.28831199
77N-Glycan biosynthesis_Homo sapiens_hsa005100.27147142
78Circadian rhythm_Homo sapiens_hsa047100.26381552
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25522337
80Prion diseases_Homo sapiens_hsa050200.25006493
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23026947
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22085457
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21608796
84Insulin resistance_Homo sapiens_hsa049310.21191649
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.20665470
86Serotonergic synapse_Homo sapiens_hsa047260.18238662
87Cocaine addiction_Homo sapiens_hsa050300.14250065
88Linoleic acid metabolism_Homo sapiens_hsa005910.13156934
89Tight junction_Homo sapiens_hsa045300.12847072
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11916831
91Glucagon signaling pathway_Homo sapiens_hsa049220.10628374
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.10625267
93Collecting duct acid secretion_Homo sapiens_hsa049660.09909041
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.07378366
95AMPK signaling pathway_Homo sapiens_hsa041520.03189656
96Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2098790
97Alzheimers disease_Homo sapiens_hsa05010-0.2053431
98Other glycan degradation_Homo sapiens_hsa00511-0.1926354
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1913136
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1771833
101Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1673954
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1524373
103Mineral absorption_Homo sapiens_hsa04978-0.1443226
104Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1332669
105Parkinsons disease_Homo sapiens_hsa05012-0.1192458
106Regulation of autophagy_Homo sapiens_hsa04140-0.1157093
107Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1107024
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1081557
109Renin-angiotensin system_Homo sapiens_hsa04614-0.1077283
110Insulin signaling pathway_Homo sapiens_hsa04910-0.1027018
111Protein digestion and absorption_Homo sapiens_hsa04974-0.0993309
112Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0804897
113Oxidative phosphorylation_Homo sapiens_hsa00190-0.0683565
114Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0647603
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0321380

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