

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 7.53946323 |
| 2 | L-phenylalanine catabolic process (GO:0006559) | 7.53946323 |
| 3 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 7.22658378 |
| 4 | L-phenylalanine metabolic process (GO:0006558) | 7.22658378 |
| 5 | aromatic amino acid family catabolic process (GO:0009074) | 6.75029059 |
| 6 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 6.47662117 |
| 7 | tryptophan catabolic process (GO:0006569) | 6.07978130 |
| 8 | indole-containing compound catabolic process (GO:0042436) | 6.07978130 |
| 9 | indolalkylamine catabolic process (GO:0046218) | 6.07978130 |
| 10 | kynurenine metabolic process (GO:0070189) | 5.97878010 |
| 11 | bile acid biosynthetic process (GO:0006699) | 5.89154509 |
| 12 | negative regulation of fibrinolysis (GO:0051918) | 5.86563694 |
| 13 | regulation of plasminogen activation (GO:0010755) | 5.82001776 |
| 14 | exogenous drug catabolic process (GO:0042738) | 5.78615461 |
| 15 | glyoxylate metabolic process (GO:0046487) | 5.78592280 |
| 16 | epoxygenase P450 pathway (GO:0019373) | 5.78558834 |
| 17 | high-density lipoprotein particle remodeling (GO:0034375) | 5.75889938 |
| 18 | tryptophan metabolic process (GO:0006568) | 5.72804564 |
| 19 | urea cycle (GO:0000050) | 5.69370302 |
| 20 | urea metabolic process (GO:0019627) | 5.69370302 |
| 21 | regulation of fibrinolysis (GO:0051917) | 5.63659419 |
| 22 | alpha-linolenic acid metabolic process (GO:0036109) | 5.50233621 |
| 23 | regulation of protein activation cascade (GO:2000257) | 5.49329680 |
| 24 | protein carboxylation (GO:0018214) | 5.46720895 |
| 25 | peptidyl-glutamic acid carboxylation (GO:0017187) | 5.46720895 |
| 26 | complement activation, alternative pathway (GO:0006957) | 5.43725557 |
| 27 | sulfur amino acid catabolic process (GO:0000098) | 5.32335941 |
| 28 | cysteine metabolic process (GO:0006534) | 5.31176322 |
| 29 | nitrogen cycle metabolic process (GO:0071941) | 5.22907320 |
| 30 | intestinal cholesterol absorption (GO:0030299) | 5.15969381 |
| 31 | regulation of complement activation (GO:0030449) | 5.10678286 |
| 32 | reverse cholesterol transport (GO:0043691) | 5.08318257 |
| 33 | serine family amino acid catabolic process (GO:0009071) | 5.06827119 |
| 34 | regulation of cholesterol esterification (GO:0010872) | 5.06687146 |
| 35 | omega-hydroxylase P450 pathway (GO:0097267) | 5.05683753 |
| 36 | bile acid metabolic process (GO:0008206) | 5.04043791 |
| 37 | plasma lipoprotein particle remodeling (GO:0034369) | 4.94916738 |
| 38 | protein-lipid complex remodeling (GO:0034368) | 4.94916738 |
| 39 | macromolecular complex remodeling (GO:0034367) | 4.94916738 |
| 40 | regulation of triglyceride catabolic process (GO:0010896) | 4.94318560 |
| 41 | aromatic amino acid family metabolic process (GO:0009072) | 4.90994353 |
| 42 | negative regulation of blood coagulation (GO:0030195) | 4.89595774 |
| 43 | negative regulation of hemostasis (GO:1900047) | 4.89595774 |
| 44 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.83653589 |
| 45 | phospholipid efflux (GO:0033700) | 4.77207006 |
| 46 | tyrosine metabolic process (GO:0006570) | 4.76123108 |
| 47 | homocysteine metabolic process (GO:0050667) | 4.72777838 |
| 48 | acylglycerol homeostasis (GO:0055090) | 4.69295720 |
| 49 | triglyceride homeostasis (GO:0070328) | 4.69295720 |
| 50 | negative regulation of sterol transport (GO:0032372) | 4.61851087 |
| 51 | negative regulation of cholesterol transport (GO:0032375) | 4.61851087 |
| 52 | regulation of apoptotic cell clearance (GO:2000425) | 4.60167454 |
| 53 | alpha-amino acid catabolic process (GO:1901606) | 4.59481682 |
| 54 | regulation of humoral immune response (GO:0002920) | 4.59179261 |
| 55 | plasma lipoprotein particle clearance (GO:0034381) | 4.56171482 |
| 56 | positive regulation of blood coagulation (GO:0030194) | 4.55393647 |
| 57 | positive regulation of hemostasis (GO:1900048) | 4.55393647 |
| 58 | amino-acid betaine metabolic process (GO:0006577) | 4.54092549 |
| 59 | lysine metabolic process (GO:0006553) | 4.53819092 |
| 60 | lysine catabolic process (GO:0006554) | 4.53819092 |
| 61 | negative regulation of coagulation (GO:0050819) | 4.48220535 |
| 62 | protein-lipid complex subunit organization (GO:0071825) | 4.46842374 |
| 63 | glycine metabolic process (GO:0006544) | 4.38857562 |
| 64 | negative regulation of wound healing (GO:0061045) | 4.38565557 |
| 65 | cellular ketone body metabolic process (GO:0046950) | 4.38447638 |
| 66 | cholesterol efflux (GO:0033344) | 4.37864113 |
| 67 | bile acid and bile salt transport (GO:0015721) | 4.35678536 |
| 68 | indolalkylamine metabolic process (GO:0006586) | 4.30978491 |
| 69 | imidazole-containing compound metabolic process (GO:0052803) | 4.30785052 |
| 70 | drug metabolic process (GO:0017144) | 4.30783845 |
| 71 | coenzyme catabolic process (GO:0009109) | 4.29558968 |
| 72 | cellular amino acid catabolic process (GO:0009063) | 4.22405504 |
| 73 | glutamate metabolic process (GO:0006536) | 4.22153937 |
| 74 | amine catabolic process (GO:0009310) | 4.21114986 |
| 75 | cellular biogenic amine catabolic process (GO:0042402) | 4.21114986 |
| 76 | plasma lipoprotein particle assembly (GO:0034377) | 4.19517449 |
| 77 | ethanol metabolic process (GO:0006067) | 4.18148745 |
| 78 | phenylpropanoid metabolic process (GO:0009698) | 4.18093013 |
| 79 | positive regulation of coagulation (GO:0050820) | 4.16830283 |
| 80 | serine family amino acid metabolic process (GO:0009069) | 4.15506237 |
| 81 | fibrinolysis (GO:0042730) | 4.15004074 |
| 82 | cellular glucuronidation (GO:0052695) | 4.14938094 |
| 83 | negative regulation of complement activation (GO:0045916) | 4.14515236 |
| 84 | benzene-containing compound metabolic process (GO:0042537) | 4.09249968 |
| 85 | low-density lipoprotein particle remodeling (GO:0034374) | 4.07651190 |
| 86 | cellular modified amino acid catabolic process (GO:0042219) | 4.04759675 |
| 87 | dicarboxylic acid biosynthetic process (GO:0043650) | 4.02419629 |
| 88 | arginine metabolic process (GO:0006525) | 4.02209604 |
| 89 | serine family amino acid biosynthetic process (GO:0009070) | 4.00184627 |
| 90 | blood coagulation, intrinsic pathway (GO:0007597) | 3.99802157 |
| 91 | ethanol oxidation (GO:0006069) | 3.99473432 |
| 92 | aldehyde catabolic process (GO:0046185) | 3.99336184 |
| 93 | oxidative demethylation (GO:0070989) | 3.97740791 |
| 94 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 3.93546277 |
| 95 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.91350451 |
| 96 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.91350451 |
| 97 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 3.87133634 |
| 98 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.84693617 |
| 99 | drug catabolic process (GO:0042737) | 3.82952727 |
| 100 | negative regulation of lipase activity (GO:0060192) | 3.82717899 |
| 101 | phospholipid homeostasis (GO:0055091) | 3.82230448 |
| 102 | complement activation, classical pathway (GO:0006958) | 3.81698086 |
| 103 | positive regulation of lipid catabolic process (GO:0050996) | 3.80482320 |
| 104 | protein activation cascade (GO:0072376) | 3.80052563 |
| 105 | cholesterol homeostasis (GO:0042632) | 3.79989721 |
| 106 | proline metabolic process (GO:0006560) | 3.79437464 |
| 107 | ketone body metabolic process (GO:1902224) | 3.79345915 |
| 108 | complement activation (GO:0006956) | 3.77439082 |
| 109 | plasma lipoprotein particle organization (GO:0071827) | 3.77169234 |
| 110 | protein-lipid complex assembly (GO:0065005) | 3.75996604 |
| 111 | sterol homeostasis (GO:0055092) | 3.73680512 |
| 112 | cytolysis (GO:0019835) | 3.68790562 |
| 113 | carboxylic acid catabolic process (GO:0046395) | 3.68583309 |
| 114 | organic acid catabolic process (GO:0016054) | 3.68583309 |
| 115 | uronic acid metabolic process (GO:0006063) | 3.67995419 |
| 116 | glucuronate metabolic process (GO:0019585) | 3.67995419 |
| 117 | regulation of bile acid biosynthetic process (GO:0070857) | 3.67384175 |
| 118 | acute-phase response (GO:0006953) | 3.66823339 |
| 119 | heme transport (GO:0015886) | 3.62264040 |
| 120 | regulation of cholesterol homeostasis (GO:2000188) | 3.62106591 |
| 121 | lipoprotein metabolic process (GO:0042157) | 3.60713035 |
| 122 | negative regulation of protein activation cascade (GO:2000258) | 3.58886266 |
| 123 | acetyl-CoA metabolic process (GO:0006084) | 3.58879957 |
| 124 | short-chain fatty acid metabolic process (GO:0046459) | 3.58457715 |
| 125 | acute inflammatory response (GO:0002526) | 3.54206945 |
| 126 | regulation of lipoprotein particle clearance (GO:0010984) | 3.49407080 |
| 127 | cholesterol transport (GO:0030301) | 3.45325143 |
| 128 | sterol transport (GO:0015918) | 3.45325143 |
| 129 | polyketide metabolic process (GO:0030638) | 3.40110868 |
| 130 | doxorubicin metabolic process (GO:0044598) | 3.40110868 |
| 131 | daunorubicin metabolic process (GO:0044597) | 3.40110868 |
| 132 | positive regulation of extracellular matrix organization (GO:1903055) | 3.35001151 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 8.36831485 |
| 2 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 7.19316617 |
| 3 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 7.04970992 |
| 4 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 6.49076284 |
| 5 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 5.29417210 |
| 6 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 5.21251493 |
| 7 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.86698619 |
| 8 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 4.08048287 |
| 9 | * NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 4.01959384 |
| 10 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 2.07913738 |
| 11 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.03252212 |
| 12 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 12.0815406 |
| 13 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.97764201 |
| 14 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.62026212 |
| 15 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.60974909 |
| 16 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.54943133 |
| 17 | GATA1_22025678_ChIP-Seq_K562_Human | 1.53608361 |
| 18 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.49326574 |
| 19 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.41454030 |
| 20 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.31161843 |
| 21 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.26536710 |
| 22 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.26282400 |
| 23 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.20430185 |
| 24 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.18239270 |
| 25 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.17874247 |
| 26 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.14808546 |
| 27 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.11214384 |
| 28 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.10845021 |
| 29 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.01484951 |
| 30 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.98829343 |
| 31 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.96736865 |
| 32 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.95455620 |
| 33 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.94176946 |
| 34 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.89841233 |
| 35 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.87418876 |
| 36 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.86095481 |
| 37 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.84086020 |
| 38 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.83271021 |
| 39 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.82262132 |
| 40 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.82004673 |
| 41 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.81594345 |
| 42 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.80238192 |
| 43 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.78331565 |
| 44 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.76932472 |
| 45 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.76554356 |
| 46 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.75937793 |
| 47 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.75571691 |
| 48 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.74574246 |
| 49 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.74458141 |
| 50 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.70965095 |
| 51 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.70763828 |
| 52 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.69806418 |
| 53 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.69341247 |
| 54 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.67832728 |
| 55 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.66785478 |
| 56 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.66462187 |
| 57 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.66181389 |
| 58 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.65142961 |
| 59 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.65082533 |
| 60 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.64868917 |
| 61 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.64435734 |
| 62 | * SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.64246442 |
| 63 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.63488254 |
| 64 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.63488254 |
| 65 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.63293557 |
| 66 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.62432696 |
| 67 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.60235692 |
| 68 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.60112739 |
| 69 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.60108557 |
| 70 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.59924915 |
| 71 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.59754140 |
| 72 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.58304422 |
| 73 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.57759452 |
| 74 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.57264085 |
| 75 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.56928006 |
| 76 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.56651850 |
| 77 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.55830936 |
| 78 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.55503845 |
| 79 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.55409332 |
| 80 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.54462605 |
| 81 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.54064126 |
| 82 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.53717694 |
| 83 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.53411031 |
| 84 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.53406949 |
| 85 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.53236629 |
| 86 | AR_20517297_ChIP-Seq_VCAP_Human | 0.52670233 |
| 87 | SOX11_22085726_ChIP-Seq_ESNs_Mouse | 0.52533152 |
| 88 | * CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.52447359 |
| 89 | * GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.52363646 |
| 90 | * FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.51873735 |
| 91 | * FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.50281961 |
| 92 | * FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.49656229 |
| 93 | * MYC_19915707_ChIP-ChIP_AK7_Human | 0.48770831 |
| 94 | ESRRB_18555785_Chip-Seq_ESCs_Mouse | 0.48686790 |
| 95 | * PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.48502104 |
| 96 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.48456262 |
| 97 | GATA1_19941826_ChIP-Seq_K562_Human | 0.47684585 |
| 98 | CBP_21632823_ChIP-Seq_H3396_Human | 0.47480664 |
| 99 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.47247974 |
| 100 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.47224185 |
| 101 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.46528730 |
| 102 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.46347057 |
| 103 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.46317164 |
| 104 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.46278100 |
| 105 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.46110670 |
| 106 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.44727182 |
| 107 | STAT1_17558387_ChIP-Seq_HELA_Human | 0.44436281 |
| 108 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.43856673 |
| 109 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.43362139 |
| 110 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.43328054 |
| 111 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.43032916 |
| 112 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.42946032 |
| 113 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.42816360 |
| 114 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.42457358 |
| 115 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.42375464 |
| 116 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.42197197 |
| 117 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.42008328 |
| 118 | GATA2_19941826_ChIP-Seq_K562_Human | 0.42007324 |
| 119 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.41925520 |
| 120 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.39960398 |
| 121 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.39251824 |
| 122 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.38376609 |
| 123 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.38087365 |
| 124 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.37557204 |
| 125 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.36118525 |
| 126 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.36091958 |
| 127 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.36052608 |
| 128 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.34819033 |
| 129 | * MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.34527903 |
| 130 | LUZP1_20508642_ChIP-Seq_ESCs_Mouse | 0.33901407 |
| 131 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.33704802 |
| 132 | NCOR_22424771_ChIP-Seq_293T_Human | 0.33640364 |
| 133 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.33386018 |
| 134 | * SPI1_26923725_Chip-Seq_HPCs_Mouse | 0.33226484 |
| 135 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.32730141 |
| 136 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.32695702 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002139_abnormal_hepatobiliary_system | 8.28330408 |
| 2 | MP0005360_urolithiasis | 7.47102535 |
| 3 | MP0005085_abnormal_gallbladder_physiolo | 6.42443956 |
| 4 | MP0005365_abnormal_bile_salt | 6.20670435 |
| 5 | MP0008875_abnormal_xenobiotic_pharmacok | 5.00988951 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 4.23649390 |
| 7 | MP0003252_abnormal_bile_duct | 3.92031739 |
| 8 | MP0010329_abnormal_lipoprotein_level | 3.63197752 |
| 9 | MP0009840_abnormal_foam_cell | 3.37026317 |
| 10 | MP0005083_abnormal_biliary_tract | 3.16298256 |
| 11 | MP0003195_calcinosis | 2.82791029 |
| 12 | MP0005332_abnormal_amino_acid | 2.73205380 |
| 13 | MP0001666_abnormal_nutrient_absorption | 2.63290745 |
| 14 | MP0003191_abnormal_cellular_cholesterol | 2.45803976 |
| 15 | MP0000609_abnormal_liver_physiology | 2.18266692 |
| 16 | MP0004019_abnormal_vitamin_homeostasis | 2.12576934 |
| 17 | MP0002118_abnormal_lipid_homeostasis | 2.10188590 |
| 18 | MP0002138_abnormal_hepatobiliary_system | 2.08247386 |
| 19 | MP0003122_maternal_imprinting | 2.00208961 |
| 20 | MP0003868_abnormal_feces_composition | 1.95629322 |
| 21 | MP0005319_abnormal_enzyme/_coenzyme | 1.81975190 |
| 22 | MP0001764_abnormal_homeostasis | 1.67802695 |
| 23 | MP0009697_abnormal_copulation | 1.63656264 |
| 24 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.55451373 |
| 25 | MP0003011_delayed_dark_adaptation | 1.50009592 |
| 26 | MP0001915_intracranial_hemorrhage | 1.46499640 |
| 27 | MP0000566_synostosis | 1.44633629 |
| 28 | MP0003656_abnormal_erythrocyte_physiolo | 1.33899617 |
| 29 | MP0005451_abnormal_body_composition | 1.33762313 |
| 30 | MP0002089_abnormal_postnatal_growth/wei | 1.28411492 |
| 31 | MP0003186_abnormal_redox_activity | 1.25976300 |
| 32 | MP0009643_abnormal_urine_homeostasis | 1.23745053 |
| 33 | MP0005058_abnormal_lysosome_morphology | 1.23591114 |
| 34 | MP0000598_abnormal_liver_morphology | 1.19831683 |
| 35 | MP0003705_abnormal_hypodermis_morpholog | 1.15062476 |
| 36 | MP0000604_amyloidosis | 1.12758082 |
| 37 | MP0005647_abnormal_sex_gland | 1.10971891 |
| 38 | MP0002254_reproductive_system_inflammat | 1.04466594 |
| 39 | MP0009764_decreased_sensitivity_to | 1.04330524 |
| 40 | MP0009763_increased_sensitivity_to | 1.03126147 |
| 41 | MP0010368_abnormal_lymphatic_system | 1.00780586 |
| 42 | MP0003123_paternal_imprinting | 0.98818065 |
| 43 | MP0005636_abnormal_mineral_homeostasis | 0.95947236 |
| 44 | MP0003172_abnormal_lysosome_physiology | 0.91323585 |
| 45 | MP0008469_abnormal_protein_level | 0.90592207 |
| 46 | MP0005084_abnormal_gallbladder_morpholo | 0.90243098 |
| 47 | MP0009642_abnormal_blood_homeostasis | 0.88280097 |
| 48 | MP0005408_hypopigmentation | 0.87046090 |
| 49 | MP0005220_abnormal_exocrine_pancreas | 0.82803142 |
| 50 | MP0006036_abnormal_mitochondrial_physio | 0.81506891 |
| 51 | MP0005376_homeostasis/metabolism_phenot | 0.80088427 |
| 52 | MP0002078_abnormal_glucose_homeostasis | 0.79645284 |
| 53 | MP0009765_abnormal_xenobiotic_induced | 0.77847958 |
| 54 | MP0005670_abnormal_white_adipose | 0.75035581 |
| 55 | MP0002876_abnormal_thyroid_physiology | 0.73912060 |
| 56 | MP0003879_abnormal_hair_cell | 0.71092007 |
| 57 | MP0002971_abnormal_brown_adipose | 0.70701490 |
| 58 | MP0005334_abnormal_fat_pad | 0.68487358 |
| 59 | MP0009053_abnormal_anal_canal | 0.68332812 |
| 60 | MP0003690_abnormal_glial_cell | 0.67148596 |
| 61 | MP0001661_extended_life_span | 0.66411794 |
| 62 | MP0004130_abnormal_muscle_cell | 0.65714360 |
| 63 | MP0004272_abnormal_basement_membrane | 0.64827357 |
| 64 | MP0005535_abnormal_body_temperature | 0.64658431 |
| 65 | MP0003329_amyloid_beta_deposits | 0.64466728 |
| 66 | MP0005167_abnormal_blood-brain_barrier | 0.63107475 |
| 67 | MP0005266_abnormal_metabolism | 0.63083057 |
| 68 | MP0000639_abnormal_adrenal_gland | 0.62814408 |
| 69 | MP0005187_abnormal_penis_morphology | 0.59654571 |
| 70 | MP0001756_abnormal_urination | 0.58744432 |
| 71 | MP0002282_abnormal_trachea_morphology | 0.57878758 |
| 72 | MP0005464_abnormal_platelet_physiology | 0.57824570 |
| 73 | MP0005448_abnormal_energy_balance | 0.55335922 |
| 74 | MP0006035_abnormal_mitochondrial_morpho | 0.54017542 |
| 75 | MP0002928_abnormal_bile_duct | 0.53769539 |
| 76 | MP0005409_darkened_coat_color | 0.52929946 |
| 77 | MP0005395_other_phenotype | 0.48983791 |
| 78 | MP0003638_abnormal_response/metabolism_ | 0.45666978 |
| 79 | MP0002822_catalepsy | 0.45142849 |
| 80 | MP0008873_increased_physiological_sensi | 0.44994036 |
| 81 | MP0003718_maternal_effect | 0.44945917 |
| 82 | MP0002136_abnormal_kidney_physiology | 0.44735539 |
| 83 | MP0009780_abnormal_chondrocyte_physiolo | 0.43559849 |
| 84 | MP0005023_abnormal_wound_healing | 0.43555060 |
| 85 | MP0005257_abnormal_intraocular_pressure | 0.42950102 |
| 86 | MP0003436_decreased_susceptibility_to | 0.42546469 |
| 87 | MP0008874_decreased_physiological_sensi | 0.41998720 |
| 88 | MP0002249_abnormal_larynx_morphology | 0.41949843 |
| 89 | MP0003724_increased_susceptibility_to | 0.41444998 |
| 90 | MP0003953_abnormal_hormone_level | 0.41376281 |
| 91 | MP0003075_altered_response_to | 0.40814590 |
| 92 | MP0004782_abnormal_surfactant_physiolog | 0.39277939 |
| 93 | MP0002837_dystrophic_cardiac_calcinosis | 0.39071937 |
| 94 | MP0009672_abnormal_birth_weight | 0.38431658 |
| 95 | MP0005166_decreased_susceptibility_to | 0.38199911 |
| 96 | MP0005248_abnormal_Harderian_gland | 0.37230132 |
| 97 | MP0003632_abnormal_nervous_system | 0.36694899 |
| 98 | MP0003567_abnormal_fetal_cardiomyocyte | 0.36070750 |
| 99 | MP0005666_abnormal_adipose_tissue | 0.35869264 |
| 100 | MP0008872_abnormal_physiological_respon | 0.35387216 |
| 101 | MP0000920_abnormal_myelination | 0.34478378 |
| 102 | MP0000579_abnormal_nail_morphology | 0.34103385 |
| 103 | MP0003878_abnormal_ear_physiology | 0.33990364 |
| 104 | MP0005377_hearing/vestibular/ear_phenot | 0.33990364 |
| 105 | MP0009384_cardiac_valve_regurgitation | 0.33981398 |
| 106 | MP0002090_abnormal_vision | 0.33732479 |
| 107 | MP0004381_abnormal_hair_follicle | 0.33601913 |
| 108 | MP0004883_abnormal_blood_vessel | 0.33438351 |
| 109 | MP0002796_impaired_skin_barrier | 0.32688881 |
| 110 | MP0003950_abnormal_plasma_membrane | 0.32589701 |
| 111 | MP0006054_spinal_hemorrhage | 0.32524729 |
| 112 | MP0009115_abnormal_fat_cell | 0.32493810 |
| 113 | MP0003183_abnormal_peptide_metabolism | 0.32313457 |
| 114 | MP0001243_abnormal_dermal_layer | 0.32253986 |
| 115 | MP0000249_abnormal_blood_vessel | 0.32224405 |
| 116 | MP0000003_abnormal_adipose_tissue | 0.31963025 |
| 117 | MP0001324_abnormal_eye_pigmentation | 0.30832128 |
| 118 | MP0003121_genomic_imprinting | 0.30792416 |
| 119 | MP0002168_other_aberrant_phenotype | 0.30369575 |
| 120 | MP0002970_abnormal_white_adipose | 0.30363865 |
| 121 | MP0001845_abnormal_inflammatory_respons | 0.29326273 |
| 122 | MP0000230_abnormal_systemic_arterial | 0.28942056 |
| 123 | MP0001881_abnormal_mammary_gland | 0.28937391 |
| 124 | MP0006082_CNS_inflammation | 0.28663931 |
| 125 | MP0001853_heart_inflammation | 0.27709947 |
| 126 | MP0003566_abnormal_cell_adhesion | 0.27603015 |
| 127 | MP0002909_abnormal_adrenal_gland | 0.27175520 |
| 128 | MP0002933_joint_inflammation | 0.27147064 |
| 129 | MP0005164_abnormal_response_to | 0.27040662 |
| 130 | MP0003943_abnormal_hepatobiliary_system | 0.26423242 |
| 131 | MP0003941_abnormal_skin_development | 0.26332907 |
| 132 | MP0000858_altered_metastatic_potential | 0.25872388 |
| 133 | MP0003115_abnormal_respiratory_system | 0.25861401 |
| 134 | MP0002132_abnormal_respiratory_system | 0.25449117 |
| 135 | MP0004264_abnormal_extraembryonic_tissu | 0.24773877 |
| 136 | MP0001944_abnormal_pancreas_morphology | 0.24746314 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Deep venous thrombosis (HP:0002625) | 7.53412362 |
| 2 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 7.37461013 |
| 3 | Intrahepatic cholestasis (HP:0001406) | 7.26490456 |
| 4 | Prolonged partial thromboplastin time (HP:0003645) | 6.69487133 |
| 5 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 6.64349620 |
| 6 | Hypobetalipoproteinemia (HP:0003563) | 6.44692422 |
| 7 | Xanthomatosis (HP:0000991) | 6.31106886 |
| 8 | Hyperlipoproteinemia (HP:0010980) | 5.52113880 |
| 9 | Complement deficiency (HP:0004431) | 5.49805557 |
| 10 | Joint hemorrhage (HP:0005261) | 4.92789631 |
| 11 | Hypolipoproteinemia (HP:0010981) | 4.86798153 |
| 12 | Abnormality of the common coagulation pathway (HP:0010990) | 4.64561439 |
| 13 | Hyperammonemia (HP:0001987) | 4.55797366 |
| 14 | Epidermoid cyst (HP:0200040) | 4.46403520 |
| 15 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 4.43974899 |
| 16 | Hyperglycinemia (HP:0002154) | 4.33260670 |
| 17 | Hypoalphalipoproteinemia (HP:0003233) | 4.26830417 |
| 18 | Abnormality of methionine metabolism (HP:0010901) | 4.24150716 |
| 19 | Ketosis (HP:0001946) | 4.21551545 |
| 20 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.18652951 |
| 21 | Fat malabsorption (HP:0002630) | 4.13795047 |
| 22 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.08798426 |
| 23 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.06087938 |
| 24 | Abnormality of complement system (HP:0005339) | 4.01926369 |
| 25 | Hypoglycemic coma (HP:0001325) | 3.95755490 |
| 26 | Abnormality of the intrinsic pathway (HP:0010989) | 3.87468099 |
| 27 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.82444304 |
| 28 | Abnormality of glycine metabolism (HP:0010895) | 3.82444304 |
| 29 | Hyperglycinuria (HP:0003108) | 3.81854687 |
| 30 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.80013702 |
| 31 | Conjugated hyperbilirubinemia (HP:0002908) | 3.69166964 |
| 32 | Hypercholesterolemia (HP:0003124) | 3.63356752 |
| 33 | Hyperbilirubinemia (HP:0002904) | 3.38300045 |
| 34 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.32026939 |
| 35 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.27203095 |
| 36 | Spontaneous abortion (HP:0005268) | 3.24295423 |
| 37 | Steatorrhea (HP:0002570) | 3.10433174 |
| 38 | Purpura (HP:0000979) | 3.09798105 |
| 39 | Hypochromic microcytic anemia (HP:0004840) | 3.05457552 |
| 40 | Hepatocellular carcinoma (HP:0001402) | 3.02521819 |
| 41 | Abnormality of nucleobase metabolism (HP:0010932) | 3.02194758 |
| 42 | Abnormality of serum amino acid levels (HP:0003112) | 3.01587417 |
| 43 | Ketoacidosis (HP:0001993) | 3.00421416 |
| 44 | Delayed CNS myelination (HP:0002188) | 2.98578401 |
| 45 | Myocardial infarction (HP:0001658) | 2.91324947 |
| 46 | Systemic lupus erythematosus (HP:0002725) | 2.77733497 |
| 47 | Skin nodule (HP:0200036) | 2.77314472 |
| 48 | Osteomalacia (HP:0002749) | 2.72603382 |
| 49 | Acanthocytosis (HP:0001927) | 2.72081353 |
| 50 | Metabolic acidosis (HP:0001942) | 2.71596072 |
| 51 | Abnormality of purine metabolism (HP:0004352) | 2.63285286 |
| 52 | Hypoglycemic seizures (HP:0002173) | 2.61142389 |
| 53 | Lethargy (HP:0001254) | 2.56567076 |
| 54 | Abnormal gallbladder morphology (HP:0012437) | 2.54377476 |
| 55 | Glomerulonephritis (HP:0000099) | 2.53542505 |
| 56 | Vascular calcification (HP:0004934) | 2.51771504 |
| 57 | Cholecystitis (HP:0001082) | 2.51520433 |
| 58 | Abnormal gallbladder physiology (HP:0012438) | 2.51520433 |
| 59 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.51468844 |
| 60 | Dicarboxylic aciduria (HP:0003215) | 2.51468844 |
| 61 | Arthropathy (HP:0003040) | 2.51019822 |
| 62 | Cholelithiasis (HP:0001081) | 2.47121538 |
| 63 | Gout (HP:0001997) | 2.44496973 |
| 64 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.43694641 |
| 65 | Amyloidosis (HP:0011034) | 2.43659717 |
| 66 | Spastic diplegia (HP:0001264) | 2.41986590 |
| 67 | Mitral stenosis (HP:0001718) | 2.40864627 |
| 68 | Cerebral edema (HP:0002181) | 2.40537002 |
| 69 | Gingival bleeding (HP:0000225) | 2.36412293 |
| 70 | Pulmonary embolism (HP:0002204) | 2.33893093 |
| 71 | Irritability (HP:0000737) | 2.33673050 |
| 72 | Neonatal onset (HP:0003623) | 2.32097379 |
| 73 | Reduced antithrombin III activity (HP:0001976) | 2.30417908 |
| 74 | Abnormality of the Achilles tendon (HP:0005109) | 2.29683107 |
| 75 | Esophageal varix (HP:0002040) | 2.28450371 |
| 76 | Abnormality of carpal bone ossification (HP:0006257) | 2.26515129 |
| 77 | Abnormal tarsal ossification (HP:0008369) | 2.26322535 |
| 78 | Cardiovascular calcification (HP:0011915) | 2.23025529 |
| 79 | Late onset (HP:0003584) | 2.22347041 |
| 80 | Malnutrition (HP:0004395) | 2.19643381 |
| 81 | Menorrhagia (HP:0000132) | 2.18807405 |
| 82 | Thrombophlebitis (HP:0004418) | 2.17792957 |
| 83 | Enlarged kidneys (HP:0000105) | 2.16348100 |
| 84 | Poikilocytosis (HP:0004447) | 2.14642772 |
| 85 | Pancreatitis (HP:0001733) | 2.13821117 |
| 86 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.13534752 |
| 87 | Sensorimotor neuropathy (HP:0007141) | 2.10535563 |
| 88 | Brushfield spots (HP:0001088) | 2.10296512 |
| 89 | Increased serum pyruvate (HP:0003542) | 2.09265299 |
| 90 | Abnormality of the gallbladder (HP:0005264) | 2.05664782 |
| 91 | Vomiting (HP:0002013) | 2.03352699 |
| 92 | Generalized aminoaciduria (HP:0002909) | 2.00794678 |
| 93 | Hemorrhage of the eye (HP:0011885) | 2.00311865 |
| 94 | Opisthotonus (HP:0002179) | 1.98620273 |
| 95 | Abnormality of iron homeostasis (HP:0011031) | 1.98586532 |
| 96 | Facial shape deformation (HP:0011334) | 1.97917040 |
| 97 | Potter facies (HP:0002009) | 1.97917040 |
| 98 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.95197484 |
| 99 | Rickets (HP:0002748) | 1.91677212 |
| 100 | Abnormality of glycolysis (HP:0004366) | 1.88317320 |
| 101 | Abnormal cartilage morphology (HP:0002763) | 1.86088541 |
| 102 | Bifid scrotum (HP:0000048) | 1.85945975 |
| 103 | Hyperglycemia (HP:0003074) | 1.84506369 |
| 104 | Renal cortical cysts (HP:0000803) | 1.81616917 |
| 105 | Hypophosphatemic rickets (HP:0004912) | 1.81595595 |
| 106 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.80935890 |
| 107 | Hydroxyprolinuria (HP:0003080) | 1.79706995 |
| 108 | Abnormality of proline metabolism (HP:0010907) | 1.79706995 |
| 109 | Elevated hepatic transaminases (HP:0002910) | 1.79332698 |
| 110 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.78954631 |
| 111 | Nephritis (HP:0000123) | 1.78497951 |
| 112 | Alkalosis (HP:0001948) | 1.76344773 |
| 113 | Gangrene (HP:0100758) | 1.74391278 |
| 114 | Broad alveolar ridges (HP:0000187) | 1.73602817 |
| 115 | Status epilepticus (HP:0002133) | 1.73111838 |
| 116 | Abnormality of the lumbar spine (HP:0100712) | 1.72546407 |
| 117 | Reticulocytosis (HP:0001923) | 1.72342701 |
| 118 | Hyperphosphaturia (HP:0003109) | 1.71695191 |
| 119 | Epistaxis (HP:0000421) | 1.71539729 |
| 120 | Flat acetabular roof (HP:0003180) | 1.68512025 |
| 121 | Abnormality of urine glucose concentration (HP:0011016) | 1.67103345 |
| 122 | Glycosuria (HP:0003076) | 1.67103345 |
| 123 | Fair hair (HP:0002286) | 1.66598023 |
| 124 | Increased serum ferritin (HP:0003281) | 1.64940642 |
| 125 | Elevated alkaline phosphatase (HP:0003155) | 1.63151163 |
| 126 | Abnormal hand bone ossification (HP:0010660) | 1.62633250 |
| 127 | Vaginal fistula (HP:0004320) | 1.62517184 |
| 128 | Abnormal ossification of hand bones (HP:0005921) | 1.61149162 |
| 129 | Joint swelling (HP:0001386) | 1.59218217 |
| 130 | Abnormal delivery (HP:0001787) | 1.58745810 |
| 131 | Abnormality of alkaline phosphatase activity (HP:0004379) | 1.55764318 |
| 132 | Small epiphyses (HP:0010585) | 1.53573552 |
| 133 | Back pain (HP:0003418) | 1.52816248 |
| 134 | Widely patent fontanelles and sutures (HP:0004492) | 1.52006795 |
| 135 | Abnormality of the nasal septum (HP:0000419) | 1.51243578 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BCKDK | 7.07554606 |
| 2 | FGFR4 | 4.66626259 |
| 3 | SIK1 | 4.46736057 |
| 4 | ERN1 | 4.46008175 |
| 5 | TAOK3 | 3.18952942 |
| 6 | INSRR | 3.07939770 |
| 7 | ERBB4 | 3.01685079 |
| 8 | WNK4 | 2.77998155 |
| 9 | CDK12 | 2.50968848 |
| 10 | MAP2K4 | 2.24397351 |
| 11 | PKN2 | 2.20153518 |
| 12 | MST1R | 2.19288350 |
| 13 | MAPK11 | 1.96233296 |
| 14 | FLT3 | 1.91508336 |
| 15 | TYRO3 | 1.90678176 |
| 16 | FGFR1 | 1.88935866 |
| 17 | PIK3CG | 1.86409889 |
| 18 | TRIB3 | 1.81983450 |
| 19 | PDGFRA | 1.79698219 |
| 20 | TYK2 | 1.70915366 |
| 21 | LATS1 | 1.65613985 |
| 22 | DAPK2 | 1.62489699 |
| 23 | PTK6 | 1.56979675 |
| 24 | NEK9 | 1.48744760 |
| 25 | AKT3 | 1.47596786 |
| 26 | ABL2 | 1.47198054 |
| 27 | FRK | 1.44888515 |
| 28 | EIF2AK1 | 1.32274075 |
| 29 | KDR | 1.31477014 |
| 30 | FGFR2 | 1.30147641 |
| 31 | JAK2 | 1.24455661 |
| 32 | WNK1 | 1.15178661 |
| 33 | MAP3K7 | 1.12904761 |
| 34 | PRKAA2 | 1.09788297 |
| 35 | MAPK15 | 1.09471622 |
| 36 | NTRK3 | 1.09010903 |
| 37 | GRK6 | 1.08482085 |
| 38 | ERBB2 | 1.07981061 |
| 39 | TBK1 | 1.04206367 |
| 40 | MAP3K10 | 1.02787326 |
| 41 | PINK1 | 1.02287367 |
| 42 | MAP2K3 | 1.02127536 |
| 43 | JAK1 | 1.00227677 |
| 44 | EEF2K | 0.99845951 |
| 45 | SIK2 | 0.97504576 |
| 46 | MAPK4 | 0.94877614 |
| 47 | SMG1 | 0.94824757 |
| 48 | MAP3K3 | 0.92507268 |
| 49 | MET | 0.92027515 |
| 50 | MAP3K14 | 0.90038781 |
| 51 | EPHA2 | 0.89982321 |
| 52 | PRKCZ | 0.89121722 |
| 53 | EPHB1 | 0.87327498 |
| 54 | MAP3K11 | 0.86928255 |
| 55 | EPHA3 | 0.84220139 |
| 56 | DDR2 | 0.83299114 |
| 57 | CDK6 | 0.81164716 |
| 58 | STK38L | 0.81036988 |
| 59 | CDK7 | 0.80273135 |
| 60 | DYRK1B | 0.80156271 |
| 61 | MAPKAPK3 | 0.77768106 |
| 62 | PRKACG | 0.77119015 |
| 63 | SGK1 | 0.76508558 |
| 64 | CSNK1E | 0.75920064 |
| 65 | MAPK12 | 0.75019557 |
| 66 | CAMK2G | 0.73687282 |
| 67 | TIE1 | 0.71985470 |
| 68 | RIPK1 | 0.71087431 |
| 69 | CAMK1D | 0.70534596 |
| 70 | CSK | 0.69337056 |
| 71 | GSK3A | 0.69095308 |
| 72 | RPS6KB1 | 0.66396538 |
| 73 | KSR2 | 0.64307973 |
| 74 | PRKAA1 | 0.62762648 |
| 75 | MAP2K6 | 0.62661852 |
| 76 | PTK2 | 0.62535636 |
| 77 | NEK1 | 0.61935423 |
| 78 | BRSK1 | 0.59961836 |
| 79 | CSNK1D | 0.59218904 |
| 80 | IRAK3 | 0.58029211 |
| 81 | BRSK2 | 0.57273260 |
| 82 | TGFBR2 | 0.57047001 |
| 83 | SGK3 | 0.56301627 |
| 84 | FGFR3 | 0.55076474 |
| 85 | MAPK7 | 0.52214045 |
| 86 | IKBKE | 0.51820815 |
| 87 | CSF1R | 0.50650257 |
| 88 | MAP2K1 | 0.50549083 |
| 89 | PRKG1 | 0.48478364 |
| 90 | PDPK1 | 0.48204940 |
| 91 | PRKCQ | 0.48113782 |
| 92 | CSNK2A2 | 0.46300975 |
| 93 | CSNK1G1 | 0.45942860 |
| 94 | CDC42BPA | 0.45733649 |
| 95 | SRC | 0.45223233 |
| 96 | TAOK2 | 0.44670636 |
| 97 | GRK1 | 0.44283783 |
| 98 | MAP3K5 | 0.43603032 |
| 99 | RPS6KA3 | 0.43400702 |
| 100 | IGF1R | 0.43173504 |
| 101 | CDK4 | 0.42710944 |
| 102 | FGR | 0.41406192 |
| 103 | BCR | 0.40729143 |
| 104 | RET | 0.40122629 |
| 105 | CSNK2A1 | 0.39824436 |
| 106 | PRKCG | 0.39237100 |
| 107 | MTOR | 0.39186395 |
| 108 | MAP3K13 | 0.39106516 |
| 109 | CDK8 | 0.38841894 |
| 110 | SCYL2 | 0.38821064 |
| 111 | SGK2 | 0.38323793 |
| 112 | EPHA4 | 0.37451314 |
| 113 | PKN1 | 0.37197478 |
| 114 | PBK | 0.36470202 |
| 115 | ICK | 0.35631081 |
| 116 | EGFR | 0.35063036 |
| 117 | PRKACA | 0.34484299 |
| 118 | PRKCB | 0.33844262 |
| 119 | MAP3K6 | 0.33395679 |
| 120 | MAP3K1 | 0.32725958 |
| 121 | MAP2K2 | 0.32296848 |
| 122 | CAMK4 | 0.31732827 |
| 123 | LMTK2 | 0.29312394 |
| 124 | PDK2 | 0.29247977 |
| 125 | SGK494 | 0.28399599 |
| 126 | SGK223 | 0.28399599 |
| 127 | PDK1 | 0.28330539 |
| 128 | STK39 | 0.28278680 |
| 129 | MAPK3 | 0.26512558 |
| 130 | PAK3 | 0.26351008 |
| 131 | PRKACB | 0.26245032 |
| 132 | CDK9 | 0.25763084 |
| 133 | PRKCA | 0.25401681 |
| 134 | CSNK1G2 | 0.24706686 |
| 135 | MATK | 0.24483248 |
| 136 | CSNK1G3 | 0.23111161 |
| 137 | IRAK1 | 0.21940622 |
| 138 | CAMK1G | 0.21002160 |
| 139 | BMX | 0.20781318 |
| 140 | LATS2 | 0.20694814 |
| 141 | ABL1 | 0.19963703 |
| 142 | MAP3K2 | 0.19600006 |
| 143 | PIK3CA | 0.19483616 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.51830647 |
| 2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.67025716 |
| 3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.41703873 |
| 4 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.32170030 |
| 5 | Arginine biosynthesis_Homo sapiens_hsa00220 | 3.10762796 |
| 6 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.88732099 |
| 7 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.67029173 |
| 8 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.64039761 |
| 9 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.62655114 |
| 10 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.56432011 |
| 11 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.47152737 |
| 12 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.35620421 |
| 13 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.20866026 |
| 14 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.12908759 |
| 15 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.11920550 |
| 16 | Peroxisome_Homo sapiens_hsa04146 | 2.05229280 |
| 17 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.94127512 |
| 18 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.90867685 |
| 19 | Histidine metabolism_Homo sapiens_hsa00340 | 1.90045795 |
| 20 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.89215598 |
| 21 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.86459873 |
| 22 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.85256748 |
| 23 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.81805128 |
| 24 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.78420842 |
| 25 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.74195266 |
| 26 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.73235936 |
| 27 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.68863442 |
| 28 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.67951828 |
| 29 | Retinol metabolism_Homo sapiens_hsa00830 | 1.66306684 |
| 30 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.60890050 |
| 31 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.60489246 |
| 32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.58091805 |
| 33 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.55994271 |
| 34 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.52035508 |
| 35 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.49555557 |
| 36 | Bile secretion_Homo sapiens_hsa04976 | 1.46768433 |
| 37 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.43245218 |
| 38 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.36570114 |
| 39 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.35422184 |
| 40 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.33073171 |
| 41 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.31503004 |
| 42 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.27988117 |
| 43 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.24203616 |
| 44 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.23628190 |
| 45 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.23399208 |
| 46 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.22376396 |
| 47 | ABC transporters_Homo sapiens_hsa02010 | 1.20021378 |
| 48 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.16737790 |
| 49 | Carbon metabolism_Homo sapiens_hsa01200 | 1.13554190 |
| 50 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.01738004 |
| 51 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.01671914 |
| 52 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.00135599 |
| 53 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.98266282 |
| 54 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.96480320 |
| 55 | Sulfur relay system_Homo sapiens_hsa04122 | 0.95656546 |
| 56 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.87680017 |
| 57 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.87068565 |
| 58 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.80988326 |
| 59 | Lysine degradation_Homo sapiens_hsa00310 | 0.80503007 |
| 60 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.77946333 |
| 61 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.71420033 |
| 62 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.68718588 |
| 63 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.67325507 |
| 64 | Other glycan degradation_Homo sapiens_hsa00511 | 0.66047076 |
| 65 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.60750781 |
| 66 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.51651499 |
| 67 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.48228591 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.45680965 |
| 69 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.45649596 |
| 70 | Pertussis_Homo sapiens_hsa05133 | 0.41903163 |
| 71 | Prion diseases_Homo sapiens_hsa05020 | 0.39266403 |
| 72 | Galactose metabolism_Homo sapiens_hsa00052 | 0.27356660 |
| 73 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.25944927 |
| 74 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.25736252 |
| 75 | Insulin resistance_Homo sapiens_hsa04931 | 0.22821886 |
| 76 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.21815285 |
| 77 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.21639292 |
| 78 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.20814380 |
| 79 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.20747519 |
| 80 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.15427155 |
| 81 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.09982155 |
| 82 | Mineral absorption_Homo sapiens_hsa04978 | 0.08755793 |
| 83 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.01350649 |
| 84 | Ether lipid metabolism_Homo sapiens_hsa00565 | -0.2456288 |
| 85 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | -0.2413391 |
| 86 | Amoebiasis_Homo sapiens_hsa05146 | -0.2372805 |
| 87 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | -0.2252904 |
| 88 | Bladder cancer_Homo sapiens_hsa05219 | -0.2217780 |
| 89 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | -0.2078558 |
| 90 | Circadian rhythm_Homo sapiens_hsa04710 | -0.2044002 |
| 91 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.1901288 |
| 92 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.1855193 |
| 93 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | -0.1839951 |
| 94 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | -0.1747072 |
| 95 | Hepatitis C_Homo sapiens_hsa05160 | -0.1703233 |
| 96 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.1564055 |
| 97 | Regulation of autophagy_Homo sapiens_hsa04140 | -0.1494136 |
| 98 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | -0.1489970 |
| 99 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | -0.1462508 |
| 100 | African trypanosomiasis_Homo sapiens_hsa05143 | -0.1370934 |
| 101 | ECM-receptor interaction_Homo sapiens_hsa04512 | -0.1131114 |
| 102 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | -0.1056195 |
| 103 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.1002867 |
| 104 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.0934986 |
| 105 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.0843854 |
| 106 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.0497230 |
| 107 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.0456520 |
| 108 | Sphingolipid metabolism_Homo sapiens_hsa00600 | -0.0034371 |

