AMBRA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.07650938
2negative regulation of erythrocyte differentiation (GO:0045647)3.84464992
3regulation of NFAT protein import into nucleus (GO:0051532)3.74048291
4regulation of chromatin binding (GO:0035561)3.54924555
5embryonic process involved in female pregnancy (GO:0060136)3.49394740
6NLS-bearing protein import into nucleus (GO:0006607)3.44626736
7locomotory exploration behavior (GO:0035641)3.44282916
8regulation of ARF protein signal transduction (GO:0032012)3.42948613
9positive regulation of histone deacetylation (GO:0031065)3.41207079
10cytoskeletal anchoring at plasma membrane (GO:0007016)3.37612834
11sodium ion export (GO:0071436)3.32839469
12COPI coating of Golgi vesicle (GO:0048205)3.31158933
13Golgi transport vesicle coating (GO:0048200)3.31158933
14regulation of ARF GTPase activity (GO:0032312)3.18755875
15synaptic vesicle maturation (GO:0016188)3.17313657
16cytoplasmic mRNA processing body assembly (GO:0033962)3.16995315
17regulation of clathrin-mediated endocytosis (GO:2000369)3.08461200
18layer formation in cerebral cortex (GO:0021819)3.07277110
19peptidyl-lysine dimethylation (GO:0018027)3.04099573
20negative regulation of cell size (GO:0045792)3.01663804
21regulation of cholesterol homeostasis (GO:2000188)2.98441906
22protein dealkylation (GO:0008214)2.92142831
23protein demethylation (GO:0006482)2.92142831
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.91799829
25macroautophagy (GO:0016236)2.90705801
26spliceosomal tri-snRNP complex assembly (GO:0000244)2.89943330
27establishment of nucleus localization (GO:0040023)2.89072375
28protein kinase C signaling (GO:0070528)2.87772036
29regulation of short-term neuronal synaptic plasticity (GO:0048172)2.87375676
303-UTR-mediated mRNA stabilization (GO:0070935)2.86850610
31negative regulation of cell killing (GO:0031342)2.86221194
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86221194
33oocyte development (GO:0048599)2.83320514
34regulation of histone H3-K27 methylation (GO:0061085)2.82952654
35apoptotic process involved in morphogenesis (GO:0060561)2.81791885
36stress granule assembly (GO:0034063)2.81248224
37establishment of protein localization to Golgi (GO:0072600)2.79877556
38dicarboxylic acid biosynthetic process (GO:0043650)2.79692904
39nuclear pore organization (GO:0006999)2.79538855
40activation of Rac GTPase activity (GO:0032863)2.77321608
41retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.76185026
42epithelial cell differentiation involved in prostate gland development (GO:0060742)2.74624671
43modulation by symbiont of host cellular process (GO:0044068)2.74128124
44response to laminar fluid shear stress (GO:0034616)2.74119857
45retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73300264
46regulation of early endosome to late endosome transport (GO:2000641)2.72344765
47protein targeting to Golgi (GO:0000042)2.72012767
48cell-substrate junction assembly (GO:0007044)2.71837188
49mRNA stabilization (GO:0048255)2.71705128
50RNA stabilization (GO:0043489)2.71705128
51peptidyl-threonine phosphorylation (GO:0018107)2.69423988
52cellular protein complex localization (GO:0034629)2.69161929
53pore complex assembly (GO:0046931)2.68050791
54negative regulation of histone methylation (GO:0031061)2.67924077
55regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67634436
56cerebellar Purkinje cell differentiation (GO:0021702)2.60470993
57insulin-like growth factor receptor signaling pathway (GO:0048009)2.59084939
58positive regulation of humoral immune response (GO:0002922)2.58068064
59peptidyl-threonine modification (GO:0018210)2.57720569
60signal complex assembly (GO:0007172)2.54140142
61cellular potassium ion homeostasis (GO:0030007)2.53930154
62regulation of fatty acid beta-oxidation (GO:0031998)2.53802138
63regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.53220225
64positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.52887610
65activation of MAPKKK activity (GO:0000185)2.52790082
66positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.52090709
67alanine transport (GO:0032328)2.51351640
68histone H3-K4 methylation (GO:0051568)2.50586813
69negative regulation of myotube differentiation (GO:0010832)2.49603810
70protein targeting to plasma membrane (GO:0072661)2.49567852
71histone H3-K4 trimethylation (GO:0080182)2.48721727
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48085459
73activation of protein kinase A activity (GO:0034199)2.47188718
74histone H3-K9 demethylation (GO:0033169)2.46949740
75positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46934195
76trophectodermal cell differentiation (GO:0001829)2.46494976
77positive regulation of Rap GTPase activity (GO:0032854)2.45449082
78positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.44658605
79protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.44141478
80modulation by virus of host process (GO:0019054)2.43463126
81cell-cell junction maintenance (GO:0045217)2.42535718
82synaptic vesicle docking involved in exocytosis (GO:0016081)2.42486179
83regulation of RNA export from nucleus (GO:0046831)2.42390810
84adherens junction assembly (GO:0034333)2.42335482
85regulation of acrosome reaction (GO:0060046)2.41974263
86mitotic chromosome condensation (GO:0007076)2.41164241
87semaphorin-plexin signaling pathway (GO:0071526)2.40661652
88regulation of nucleobase-containing compound transport (GO:0032239)2.39449656
89regulation of translational termination (GO:0006449)2.39340748
90positive thymic T cell selection (GO:0045059)2.39028121
91protein localization to endosome (GO:0036010)2.38749104
92glucocorticoid receptor signaling pathway (GO:0042921)2.38585597
93corticosteroid receptor signaling pathway (GO:0031958)2.38455414
94nuclear pore complex assembly (GO:0051292)2.38156853
95activation of JUN kinase activity (GO:0007257)2.38104451
96cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.37867058
97regulation of protein polyubiquitination (GO:1902914)2.37389355
98dendrite morphogenesis (GO:0048813)2.37338657
99nerve growth factor signaling pathway (GO:0038180)2.36916892
100epithelial cell-cell adhesion (GO:0090136)2.36306796
101positive regulation of Cdc42 GTPase activity (GO:0043089)2.35311448
102regulation of gamma-delta T cell differentiation (GO:0045586)2.34728290
103histone lysine demethylation (GO:0070076)2.34157719
104negative regulation of viral release from host cell (GO:1902187)2.33872702
105intracellular estrogen receptor signaling pathway (GO:0030520)2.33051308
106neuromuscular process controlling balance (GO:0050885)2.32722070
107glutamate secretion (GO:0014047)2.31980171
108histone H3-K36 demethylation (GO:0070544)2.31474435
109activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.31071688
110proline transport (GO:0015824)2.29968602
111regulation of Rap GTPase activity (GO:0032317)2.29863887
112cellular response to virus (GO:0098586)2.29401218
113cellular response to epidermal growth factor stimulus (GO:0071364)2.29114864
114regulation of female gonad development (GO:2000194)2.28842906
115focal adhesion assembly (GO:0048041)2.27952168
116cell-substrate adherens junction assembly (GO:0007045)2.27952168
117urea cycle (GO:0000050)2.27513269
118branching involved in mammary gland duct morphogenesis (GO:0060444)2.26605079
119citrulline metabolic process (GO:0000052)2.26120236
120embryonic eye morphogenesis (GO:0048048)2.26041337
121positive regulation of synapse maturation (GO:0090129)2.24029722
122embryonic camera-type eye morphogenesis (GO:0048596)2.23286542
123amyloid precursor protein catabolic process (GO:0042987)2.22923827
124positive regulation of nuclease activity (GO:0032075)2.22289546
125positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.21626680
126G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.21493575
127cell communication by electrical coupling (GO:0010644)2.20867976
128regulation of translational fidelity (GO:0006450)2.20774659
129intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.20247530
130receptor catabolic process (GO:0032801)2.19642378
131vesicle coating (GO:0006901)2.19590372
132response to muramyl dipeptide (GO:0032495)2.18904180
133negative regulation of histone modification (GO:0031057)2.18856734
134clathrin coat assembly (GO:0048268)2.18299419
135barbed-end actin filament capping (GO:0051016)2.18245492
136negative regulation of fatty acid transport (GO:2000192)2.18148220
137cortical actin cytoskeleton organization (GO:0030866)2.17819620
138gamma-aminobutyric acid transport (GO:0015812)2.17755007
139amyloid precursor protein metabolic process (GO:0042982)2.17540561
140histone H4 deacetylation (GO:0070933)2.17144326
141positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.17040186
142regulation of histone H3-K9 methylation (GO:0051570)2.16595812
143protein complex localization (GO:0031503)2.16410064
144mannose metabolic process (GO:0006013)2.16203716
145planar cell polarity pathway involved in neural tube closure (GO:0090179)2.16078304
146histone H4-K16 acetylation (GO:0043984)2.15983877
147thymic T cell selection (GO:0045061)2.14971881
148positive regulation of gene expression, epigenetic (GO:0045815)2.14271561
149potassium ion import (GO:0010107)2.13874563
150histone lysine methylation (GO:0034968)2.13179974
151glial cell proliferation (GO:0014009)2.12406535
152negative regulation of potassium ion transmembrane transport (GO:1901380)2.11363844
153mitotic sister chromatid cohesion (GO:0007064)2.10092885
154prepulse inhibition (GO:0060134)2.09379487
155plasma membrane repair (GO:0001778)2.09276511
156histone demethylation (GO:0016577)2.08958425
157positive regulation of fatty acid beta-oxidation (GO:0032000)2.08810091
158regulation of gamma-delta T cell activation (GO:0046643)2.08489135
159negative regulation of sodium ion transport (GO:0010766)2.08282495
160heterochromatin organization (GO:0070828)2.07743197
161cellular sodium ion homeostasis (GO:0006883)2.07604062
162negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.06526166
163regulation of glutamate receptor signaling pathway (GO:1900449)2.06116226
164growth hormone receptor signaling pathway (GO:0060396)2.05936420
165stress fiber assembly (GO:0043149)2.05372609
166positive regulation of glycogen biosynthetic process (GO:0045725)2.04914078
167regulation of p38MAPK cascade (GO:1900744)2.03791974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.61635566
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.99687373
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.89859045
4MYC_22102868_ChIP-Seq_BL_Human2.70133485
5E2F7_22180533_ChIP-Seq_HELA_Human2.61107469
6KDM2B_26808549_Chip-Seq_DND41_Human2.54132510
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.51463265
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.45475035
9* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.38108449
10* TCF7_22412390_ChIP-Seq_EML_Mouse2.24777171
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21076509
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.21021338
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.20867511
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.12070148
15KDM2B_26808549_Chip-Seq_K562_Human2.07861614
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01663346
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.00994503
18DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.98545673
19KDM2B_26808549_Chip-Seq_JURKAT_Human1.98135962
20DROSHA_22980978_ChIP-Seq_HELA_Human1.97957721
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.96778422
22ZFP281_27345836_Chip-Seq_ESCs_Mouse1.93474869
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.91470347
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88061825
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82570485
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67432422
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66633215
28EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65713881
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64740719
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.63345076
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62456030
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61424159
33GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60942360
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54909079
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.54895964
36* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50645717
37LXR_22292898_ChIP-Seq_THP-1_Human1.50405647
38CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50077996
39VDR_24763502_ChIP-Seq_THP-1_Human1.46996546
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43920340
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43830968
42* FOXA2_19822575_ChIP-Seq_HepG2_Human1.43634405
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41578761
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.40791967
45* CREB1_26743006_Chip-Seq_LNCaP_Human1.40376839
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40227427
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37249418
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36977798
49VDR_21846776_ChIP-Seq_THP-1_Human1.35720414
50* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33380813
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32151006
52* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31835523
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.31113899
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30937713
55ZNF263_19887448_ChIP-Seq_K562_Human1.28699827
56* UTX_26944678_Chip-Seq_JUKART_Human1.28649600
57* ELK3_25401928_ChIP-Seq_HUVEC_Human1.26720154
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26269735
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.23323892
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22565578
61* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22211300
62* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22127089
63* RACK7_27058665_Chip-Seq_MCF-7_Human1.20029289
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19727386
65ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19522321
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.19291903
67* SPI1_23127762_ChIP-Seq_K562_Human1.18180429
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18160598
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17853029
70FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17484867
71P68_20966046_ChIP-Seq_HELA_Human1.15661795
72RXR_22158963_ChIP-Seq_LIVER_Mouse1.15412897
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15360892
74* MAF_26560356_Chip-Seq_TH1_Human1.15082325
75RUNX_20019798_ChIP-Seq_JUKART_Human1.14997083
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14670842
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14182263
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14004871
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13943779
80GATA1_19941826_ChIP-Seq_K562_Human1.13720759
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13286243
82ATF3_27146783_Chip-Seq_COLON_Human1.12823675
83TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12530338
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.12481777
85* TP53_22127205_ChIP-Seq_IMR90_Human1.12456186
86* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12088871
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.11832168
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11367198
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10996494
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09422762
91* MAF_26560356_Chip-Seq_TH2_Human1.07445442
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07427282
93* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07267199
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.06480894
95PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06435875
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06322730
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.05702504
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05270428
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04989603
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04407172
101SCL_19346495_ChIP-Seq_HPC-7_Human1.03989727
102AR_19668381_ChIP-Seq_PC3_Human1.03819891
103SMC4_20622854_ChIP-Seq_HELA_Human1.03367722
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03058444
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02659521
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01906420
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01560724
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00579087
109GATA2_19941826_ChIP-Seq_K562_Human1.00532396
110* UBF1/2_26484160_Chip-Seq_HMECs_Human0.99873098
111TET1_21451524_ChIP-Seq_MESCs_Mouse0.99690220
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.99551420
113* TBX20_22328084_ChIP-Seq_HEART_Mouse0.99117454
114* TBX20_22080862_ChIP-Seq_HEART_Mouse0.99117454
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98933727
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98746335
117* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98059913
118CLOCK_20551151_ChIP-Seq_293T_Human0.97804090
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96603631
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96594275
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95340378
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95179155
123AHR_22903824_ChIP-Seq_MCF-7_Human0.94854794
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94814742
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94082752
126* GATA1_19941827_ChIP-Seq_MEL_Mouse0.94002498
127TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93477726
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93218778
129TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92962710
130GATA1_22025678_ChIP-Seq_K562_Human0.91428215
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90909532
132* NCOR1_26117541_ChIP-Seq_K562_Human0.89329091
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.88219151
134TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88078157
135OCT4_19829295_ChIP-Seq_ESCs_Human0.87541458
136RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87424640
137MITF_21258399_ChIP-Seq_MELANOMA_Human0.87363330
138REST_21632747_ChIP-Seq_MESCs_Mouse0.86012544
139FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85189561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.63089726
2MP0004859_abnormal_synaptic_plasticity4.05939379
3MP0008961_abnormal_basal_metabolism3.53921336
4MP0005451_abnormal_body_composition3.50285774
5MP0003705_abnormal_hypodermis_morpholog3.24645986
6MP0005076_abnormal_cell_differentiation3.08368637
7MP0003300_gastrointestinal_ulcer2.74161506
8MP0008260_abnormal_autophagy2.63581665
9MP0005058_abnormal_lysosome_morphology2.29768967
10MP0005409_darkened_coat_color2.29718393
11MP0003453_abnormal_keratinocyte_physiol2.21753693
12MP0009278_abnormal_bone_marrow2.15329137
13MP0009780_abnormal_chondrocyte_physiolo2.14600268
14MP0010352_gastrointestinal_tract_polyps2.11845460
15MP0010234_abnormal_vibrissa_follicle2.09616667
16MP0008057_abnormal_DNA_replication2.08559277
17MP0002822_catalepsy2.03785638
18MP0004858_abnormal_nervous_system1.96505122
19MP0003303_peritoneal_inflammation1.96420620
20MP0004233_abnormal_muscle_weight1.95660650
21MP0003045_fibrosis1.89504388
22MP0004510_myositis1.79214359
23MP0003635_abnormal_synaptic_transmissio1.70644890
24MP0003252_abnormal_bile_duct1.68865451
25MP0004270_analgesia1.62654949
26MP0002909_abnormal_adrenal_gland1.62159281
27MP0003283_abnormal_digestive_organ1.59344617
28MP0005670_abnormal_white_adipose1.58083098
29MP0004130_abnormal_muscle_cell1.57012617
30MP0005360_urolithiasis1.55453589
31MP0002009_preneoplasia1.49884440
32MP0005365_abnormal_bile_salt1.49777799
33MP0003787_abnormal_imprinting1.49372508
34MP0010307_abnormal_tumor_latency1.45193136
35MP0003091_abnormal_cell_migration1.43745429
36MP0003172_abnormal_lysosome_physiology1.41677007
37MP0005257_abnormal_intraocular_pressure1.39356756
38MP0003656_abnormal_erythrocyte_physiolo1.38669396
39* MP0005621_abnormal_cell_physiology1.38193074
40MP0003763_abnormal_thymus_physiology1.37203904
41MP0003111_abnormal_nucleus_morphology1.36944039
42MP0005666_abnormal_adipose_tissue1.34278191
43MP0004185_abnormal_adipocyte_glucose1.33762676
44MP0000733_abnormal_muscle_development1.33658416
45MP0002139_abnormal_hepatobiliary_system1.32343615
46MP0001348_abnormal_lacrimal_gland1.32309826
47MP0003436_decreased_susceptibility_to1.29458505
48MP0005187_abnormal_penis_morphology1.28402938
49MP0002796_impaired_skin_barrier1.26900524
50MP0004381_abnormal_hair_follicle1.26830410
51MP0002063_abnormal_learning/memory/cond1.24844605
52MP0009046_muscle_twitch1.24304227
53MP0005375_adipose_tissue_phenotype1.20870565
54MP0003566_abnormal_cell_adhesion1.20450875
55MP0001849_ear_inflammation1.18346112
56MP0009672_abnormal_birth_weight1.17373067
57MP0009703_decreased_birth_body1.15382969
58MP0004087_abnormal_muscle_fiber1.13547104
59MP0000751_myopathy1.12436869
60MP0002166_altered_tumor_susceptibility1.12117492
61MP0005083_abnormal_biliary_tract1.11586841
62MP0004811_abnormal_neuron_physiology1.10749505
63MP0000003_abnormal_adipose_tissue1.09949472
64MP0008438_abnormal_cutaneous_collagen1.09124079
65MP0010630_abnormal_cardiac_muscle1.08884218
66MP0000604_amyloidosis1.08638241
67MP0004885_abnormal_endolymph1.08312303
68MP0003329_amyloid_beta_deposits1.07674217
69MP0010329_abnormal_lipoprotein_level1.06715360
70MP0008569_lethality_at_weaning1.06346770
71MP0002998_abnormal_bone_remodeling1.05008311
72MP0003123_paternal_imprinting1.02689848
73MP0002269_muscular_atrophy1.00838466
74MP0008770_decreased_survivor_rate1.00649060
75MP0002928_abnormal_bile_duct0.99918948
76* MP0000350_abnormal_cell_proliferation0.99863855
77MP0004947_skin_inflammation0.99683616
78MP0004197_abnormal_fetal_growth/weight/0.98445087
79MP0000371_diluted_coat_color0.95990801
80MP0000609_abnormal_liver_physiology0.95618813
81MP0002086_abnormal_extraembryonic_tissu0.94224479
82MP0003191_abnormal_cellular_cholesterol0.93812311
83MP0009840_abnormal_foam_cell0.93596253
84* MP0005384_cellular_phenotype0.92834513
85MP0002653_abnormal_ependyma_morphology0.92788848
86MP0005501_abnormal_skin_physiology0.92660480
87* MP0002080_prenatal_lethality0.90787693
88MP0002064_seizures0.90732317
89MP0002060_abnormal_skin_morphology0.90293597
90MP0000537_abnormal_urethra_morphology0.88849757
91MP0002254_reproductive_system_inflammat0.88841230
92MP0003115_abnormal_respiratory_system0.86695124
93MP0000428_abnormal_craniofacial_morphol0.86540832
94MP0009115_abnormal_fat_cell0.86466264
95MP0004264_abnormal_extraembryonic_tissu0.86388442
96MP0003984_embryonic_growth_retardation0.85564324
97MP0000767_abnormal_smooth_muscle0.85324927
98MP0002088_abnormal_embryonic_growth/wei0.85224609
99MP0003075_altered_response_to0.84557744
100MP0002084_abnormal_developmental_patter0.84032473
101MP0002098_abnormal_vibrissa_morphology0.83828490
102MP0003633_abnormal_nervous_system0.83185207
103MP0002925_abnormal_cardiovascular_devel0.82710100
104MP0002089_abnormal_postnatal_growth/wei0.82425782
105MP0000858_altered_metastatic_potential0.82172441
106MP0003690_abnormal_glial_cell0.81746335
107MP0005085_abnormal_gallbladder_physiolo0.81452027
108MP0001545_abnormal_hematopoietic_system0.81246944
109MP0005397_hematopoietic_system_phenotyp0.81246944
110MP0003077_abnormal_cell_cycle0.80309504
111MP0003646_muscle_fatigue0.79795204
112MP0003699_abnormal_female_reproductive0.79747569
113MP0001730_embryonic_growth_arrest0.79618130
114MP0000747_muscle_weakness0.79113465
115MP0005380_embryogenesis_phenotype0.79063867
116MP0001672_abnormal_embryogenesis/_devel0.79063867
117MP0003632_abnormal_nervous_system0.78870577
118MP0000759_abnormal_skeletal_muscle0.78593324
119MP0005623_abnormal_meninges_morphology0.77330067
120MP0009745_abnormal_behavioral_response0.77247858
121MP0000015_abnormal_ear_pigmentation0.76852055
122MP0000266_abnormal_heart_morphology0.76823041
123MP0000377_abnormal_hair_follicle0.76602884
124MP0003634_abnormal_glial_cell0.76221145
125MP0009931_abnormal_skin_appearance0.75567890
126MP0001299_abnormal_eye_distance/0.75510910
127MP0003890_abnormal_embryonic-extraembry0.73779433
128* MP0002152_abnormal_brain_morphology0.73034805
129MP0003631_nervous_system_phenotype0.72639865
130MP0009333_abnormal_splenocyte_physiolog0.72636919
131MP0008874_decreased_physiological_sensi0.72353750
132* MP0000955_abnormal_spinal_cord0.71357568
133MP0003828_pulmonary_edema0.70858245
134MP0001697_abnormal_embryo_size0.70840612
135MP0001915_intracranial_hemorrhage0.70760532
136MP0002092_abnormal_eye_morphology0.70636699
137MP0002398_abnormal_bone_marrow0.70345408
138MP0002877_abnormal_melanocyte_morpholog0.70280722
139MP0000678_abnormal_parathyroid_gland0.70225599
140MP0010030_abnormal_orbit_morphology0.69952413
141MP0001661_extended_life_span0.69303850
142MP0001216_abnormal_epidermal_layer0.69195574
143MP0000703_abnormal_thymus_morphology0.68318475
144MP0003183_abnormal_peptide_metabolism0.67823462
145MP0005023_abnormal_wound_healing0.67698136
146MP0002572_abnormal_emotion/affect_behav0.67678947
147MP0004808_abnormal_hematopoietic_stem0.67210408
148MP0010678_abnormal_skin_adnexa0.66556201
149MP0001784_abnormal_fluid_regulation0.65657846
150MP0002396_abnormal_hematopoietic_system0.65098132

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)3.60434543
2Macroorchidism (HP:0000053)3.51762638
3Dysmetric saccades (HP:0000641)3.28736793
4Hyperacusis (HP:0010780)3.24886839
5Abnormality of the fingertips (HP:0001211)3.15629722
6Cerebral aneurysm (HP:0004944)2.96513856
7Heterotopia (HP:0002282)2.89019618
8Flat acetabular roof (HP:0003180)2.75001363
9Broad face (HP:0000283)2.71448562
10Distal upper limb amyotrophy (HP:0007149)2.65070691
11Upper limb amyotrophy (HP:0009129)2.65070691
12Hand muscle atrophy (HP:0009130)2.64778122
13Urethral obstruction (HP:0000796)2.64337755
14Genetic anticipation (HP:0003743)2.62289407
15Astrocytoma (HP:0009592)2.58458096
16Abnormality of the astrocytes (HP:0100707)2.58458096
17Elfin facies (HP:0004428)2.56758580
18Obstructive sleep apnea (HP:0002870)2.45203700
19Pointed chin (HP:0000307)2.38118995
20Turricephaly (HP:0000262)2.35606725
21Urinary bladder sphincter dysfunction (HP:0002839)2.35105012
22Enlarged penis (HP:0000040)2.32837771
23Renovascular hypertension (HP:0100817)2.28178629
24Neoplasm of the heart (HP:0100544)2.26530278
25Sparse lateral eyebrow (HP:0005338)2.25355100
26Pseudobulbar signs (HP:0002200)2.23762543
27Abnormality of the thoracic spine (HP:0100711)2.22894947
28Narrow palate (HP:0000189)2.22465792
29Asymmetry of the thorax (HP:0001555)2.15423809
30Hemiplegia (HP:0002301)2.13381711
31Abnormality of the distal phalanx of the thumb (HP:0009617)2.12253772
32Ependymoma (HP:0002888)2.12118405
33Long palpebral fissure (HP:0000637)2.10489335
34Long eyelashes (HP:0000527)2.08995396
35Germ cell neoplasia (HP:0100728)2.05966081
36Shallow orbits (HP:0000586)2.02189176
37Insomnia (HP:0100785)2.01913620
38Thin bony cortex (HP:0002753)1.99988768
39Focal seizures (HP:0007359)1.98993590
40Postural instability (HP:0002172)1.98216587
41Uterine leiomyosarcoma (HP:0002891)1.97290157
42Leiomyosarcoma (HP:0100243)1.97290157
43Urinary urgency (HP:0000012)1.96657309
44Increased connective tissue (HP:0009025)1.95306322
45Renal cell carcinoma (HP:0005584)1.94778907
46Difficulty running (HP:0009046)1.94715723
47Aneurysm (HP:0002617)1.94088020
48Volvulus (HP:0002580)1.92243757
49Persistence of primary teeth (HP:0006335)1.92029543
50Obsessive-compulsive behavior (HP:0000722)1.91926877
51Advanced eruption of teeth (HP:0006288)1.91303249
52Cerebral inclusion bodies (HP:0100314)1.90203488
53Impaired smooth pursuit (HP:0007772)1.90119326
54Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90097967
55Subacute progressive viral hepatitis (HP:0006572)1.89914325
56Short 4th metacarpal (HP:0010044)1.89571006
57Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89571006
58Bundle branch block (HP:0011710)1.88878174
59Abnormal social behavior (HP:0012433)1.88114185
60Impaired social interactions (HP:0000735)1.88114185
61Amyotrophic lateral sclerosis (HP:0007354)1.85457835
62Abnormality of ocular smooth pursuit (HP:0000617)1.84543191
63Hemorrhage of the eye (HP:0011885)1.84405338
64Distal lower limb amyotrophy (HP:0008944)1.83660866
65Lymphangioma (HP:0100764)1.83453245
66Reticulocytosis (HP:0001923)1.83413678
67Protrusio acetabuli (HP:0003179)1.82970220
68Trigonocephaly (HP:0000243)1.81848630
69Long toe (HP:0010511)1.81804904
70Aqueductal stenosis (HP:0002410)1.81084393
71Glioma (HP:0009733)1.80678730
72Resting tremor (HP:0002322)1.80619362
73Cellulitis (HP:0100658)1.79221604
74Impaired vibration sensation in the lower limbs (HP:0002166)1.78890367
75Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78113084
76Deep palmar crease (HP:0006191)1.77790704
77Mitral valve prolapse (HP:0001634)1.77185022
78Truncal obesity (HP:0001956)1.76677477
79Vertebral arch anomaly (HP:0008438)1.75426242
80Dislocated radial head (HP:0003083)1.75263792
81Gastrointestinal carcinoma (HP:0002672)1.75035603
82Malignant gastrointestinal tract tumors (HP:0006749)1.75035603
83Neurofibrillary tangles (HP:0002185)1.74847360
84Spinal cord lesions (HP:0100561)1.73760927
85Syringomyelia (HP:0003396)1.73760927
86Disproportionate tall stature (HP:0001519)1.73246007
87Renal duplication (HP:0000075)1.72904673
88Action tremor (HP:0002345)1.72621861
89Striae distensae (HP:0001065)1.72264807
90Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.72145064
91Deep venous thrombosis (HP:0002625)1.69999036
92Ankyloglossia (HP:0010296)1.69804899
93Global brain atrophy (HP:0002283)1.69206792
94Micronodular cirrhosis (HP:0001413)1.67487194
95Hypoplastic ischia (HP:0003175)1.67154632
96Prominent nose (HP:0000448)1.67042939
97Bowel incontinence (HP:0002607)1.66958626
98Neuronal loss in central nervous system (HP:0002529)1.66539670
99Lip pit (HP:0100267)1.65919213
100Lower limb amyotrophy (HP:0007210)1.65251416
101Abnormality of the 4th metacarpal (HP:0010012)1.65145742
102Thoracic kyphosis (HP:0002942)1.64414769
103Sandal gap (HP:0001852)1.64300372
104Insidious onset (HP:0003587)1.63498044
105Termporal pattern (HP:0011008)1.63498044
106Transitional cell carcinoma of the bladder (HP:0006740)1.63493958
107Abnormality of the radial head (HP:0003995)1.63045921
108Abnormal ossification of hand bones (HP:0005921)1.62905489
109Frequent falls (HP:0002359)1.62393220
110Bowel diverticulosis (HP:0005222)1.62334592
111Osteolytic defects of the phalanges of the hand (HP:0009771)1.61696662
112Osteolytic defects of the hand bones (HP:0009699)1.61696662
113Cervical subluxation (HP:0003308)1.61646904
114EMG: neuropathic changes (HP:0003445)1.61646365
115Broad thumb (HP:0011304)1.60577200
116Sacral dimple (HP:0000960)1.59826642
117Abnormality of the columella (HP:0009929)1.59804596
118Ulnar bowing (HP:0003031)1.59630932
119Skull defect (HP:0001362)1.59624874
120Supranuclear gaze palsy (HP:0000605)1.59578906
121Loss of speech (HP:0002371)1.59506668
122Natal tooth (HP:0000695)1.59475624
123Viral hepatitis (HP:0006562)1.58972535
124Overriding aorta (HP:0002623)1.58514489
125Tetraplegia (HP:0002445)1.58159414
126Apathy (HP:0000741)1.57720254
127Abnormality of the Achilles tendon (HP:0005109)1.57522576
128Abnormal large intestine physiology (HP:0012700)1.57151199
129Centrally nucleated skeletal muscle fibers (HP:0003687)1.57120889
130Arnold-Chiari malformation (HP:0002308)1.56943324
131Bladder carcinoma (HP:0002862)1.56744102
132Bladder neoplasm (HP:0009725)1.56744102
133Premature skin wrinkling (HP:0100678)1.56610388
134Open mouth (HP:0000194)1.56545491
135Broad palm (HP:0001169)1.56383868
136Increased CSF protein (HP:0002922)1.55636508
137Colitis (HP:0002583)1.54588226
138Metaphyseal cupping (HP:0003021)1.54191737
139Visceral angiomatosis (HP:0100761)1.53954270
140Rectal prolapse (HP:0002035)1.53758790
141Achilles tendon contracture (HP:0001771)1.53569023
142Precocious puberty (HP:0000826)1.53467554
143Cholecystitis (HP:0001082)1.52846795
144Abnormal gallbladder physiology (HP:0012438)1.52846795
145Hemangiomatosis (HP:0007461)1.52778712
146Slow saccadic eye movements (HP:0000514)1.52509866
147Increased nuchal translucency (HP:0010880)1.52313893
148Upper motor neuron abnormality (HP:0002127)1.52202142
149Dysdiadochokinesis (HP:0002075)1.51724998
150Abnormality of the salivary glands (HP:0010286)1.51693536
151Hypopigmentation of the fundus (HP:0007894)1.51415332
152Decreased motor nerve conduction velocity (HP:0003431)1.51406631
153Vertebral compression fractures (HP:0002953)1.51387147
154Broad metatarsal (HP:0001783)1.50803842
155Anal stenosis (HP:0002025)1.50685548
156Genu recurvatum (HP:0002816)1.50358613
157Status epilepticus (HP:0002133)1.49704941
158Visual hallucinations (HP:0002367)1.49502838
159Deep philtrum (HP:0002002)1.49344362
160Papillary thyroid carcinoma (HP:0002895)1.48907007
161Eczematoid dermatitis (HP:0000976)1.47439487
162Hyporeflexia of lower limbs (HP:0002600)1.47298752
163Absent frontal sinuses (HP:0002688)1.47102903
164Mitral regurgitation (HP:0001653)1.47077802
165Overgrowth (HP:0001548)1.46675914
166Truncal ataxia (HP:0002078)1.46278346
167Attention deficit hyperactivity disorder (HP:0007018)1.46036384
168Hypoplasia of the iris (HP:0007676)1.45750206
169Skin tags (HP:0010609)1.45602122
170Annular pancreas (HP:0001734)1.45347802
171Abnormality of oral frenula (HP:0000190)1.45056826
172Fibroma (HP:0010614)1.44748571
173Thick eyebrow (HP:0000574)1.44637523
174High anterior hairline (HP:0009890)1.43614471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.87492271
2CDK123.33874019
3SMG13.29347410
4TRIB32.74061976
5EEF2K2.71792119
6PKN22.63388159
7ICK2.52630245
8MAP3K92.43665985
9CAMK1G2.27591373
10RIPK12.13803496
11CAMK1D2.08831433
12MAP3K101.96371815
13IRAK31.93845937
14TAOK11.85281583
15DAPK21.84315494
16PRKD31.83118590
17SIK21.75780737
18LATS11.65014548
19TYRO31.62078104
20SIK11.57623665
21MAP3K41.55550842
22ALK1.52546667
23PDGFRA1.50526021
24PAK61.40963436
25MTOR1.37972160
26TTN1.34095026
27PTK61.31555643
28KSR21.31100603
29PRKCH1.29700083
30FGFR41.29074449
31BMX1.25893993
32SGK31.25836981
33MAP3K131.23546163
34RET1.22795698
35STK381.22450393
36EPHA41.21795050
37MAP3K111.19509619
38DMPK1.17960038
39ERN11.17154556
40BRD41.15412911
41NTRK21.15093022
42JAK11.13104918
43CAMKK11.12165961
44MARK11.10002195
45MAP4K11.08716663
46TAOK21.08060655
47MAP3K31.07896576
48FGFR31.05682190
49MAP2K31.03630762
50MAP3K71.01591567
51LATS21.00940654
52MARK20.99579126
53NTRK30.99077075
54FGFR20.95291673
55PDGFRB0.94989097
56MAP3K10.92594472
57WNK10.92003269
58MAP3K140.91809562
59CDC42BPA0.90464580
60SCYL20.87148030
61AKT30.83197493
62STK110.82693853
63CDK40.79979643
64RPS6KC10.79610277
65RPS6KL10.79610277
66NEK60.77148880
67KSR10.75563739
68PDK10.72896945
69JAK20.71846247
70CDK90.71430095
71MAP2K40.71423691
72CDK60.71364731
73PRKAA10.71099509
74PTK20.70433100
75CAMK40.70204682
76SGK20.69314098
77GRK60.66684568
78DDR20.64995330
79FGFR10.64665638
80BRAF0.64572732
81CDK70.64515966
82MST1R0.63224988
83NEK20.63219236
84SGK10.62850814
85LMTK20.62772124
86MET0.62512243
87TAOK30.62180409
88ARAF0.61473056
89MAP3K20.61420916
90EPHA20.58678289
91TYK20.58144391
92RPS6KB20.57313745
93PRKD20.56698001
94PNCK0.55605037
95MAPK110.55501184
96RPS6KA60.54854555
97CDK50.54623533
98MAP3K80.54046398
99PDPK10.53873315
100MAPK100.53829667
101IRAK40.53257805
102MAPK80.53135945
103HCK0.53072865
104SGK4940.52751557
105SGK2230.52751557
106PAK40.52398366
107MINK10.52266300
108EPHB10.51771407
109DAPK10.51638105
110ZAP700.51498998
111STK100.51297678
112RPS6KA30.49156185
113DYRK1B0.48685363
114RPS6KA20.48389169
115BLK0.48007518
116HIPK20.47268291
117NTRK10.46915410
118PIM10.46823961
119ITK0.46338541
120MELK0.46055024
121CSF1R0.45389157
122PHKG10.44347949
123PHKG20.44347949
124NEK10.44317346
125MAPK120.44303440
126IRAK20.43597833
127MAP3K60.43371518
128STK40.43150573
129CSNK1D0.42882092
130CHUK0.42825300
131STK30.42552518
132GSK3B0.42359165
133TRPM70.41116873
134CHEK10.40233397
135MAP2K20.40201044
136PAK30.39902395
137JAK30.39512914
138ERBB20.39204977
139RPS6KA10.38519915
140TBK10.37785584

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.46305356
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.96625791
3Type II diabetes mellitus_Homo sapiens_hsa049301.82683465
4Lysine degradation_Homo sapiens_hsa003101.80577495
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79934032
6mTOR signaling pathway_Homo sapiens_hsa041501.78767839
7Other glycan degradation_Homo sapiens_hsa005111.62283341
8Dorso-ventral axis formation_Homo sapiens_hsa043201.61909738
9Thyroid cancer_Homo sapiens_hsa052161.54236372
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48488437
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45586153
12Thyroid hormone signaling pathway_Homo sapiens_hsa049191.39815824
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36388886
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33108383
15Arginine biosynthesis_Homo sapiens_hsa002201.32250087
16Chronic myeloid leukemia_Homo sapiens_hsa052201.30180118
17Insulin resistance_Homo sapiens_hsa049311.27892914
18Bladder cancer_Homo sapiens_hsa052191.27845614
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27138914
20Bile secretion_Homo sapiens_hsa049761.26713704
21Hepatitis B_Homo sapiens_hsa051611.25485490
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24341818
23Glioma_Homo sapiens_hsa052141.23187461
24Long-term potentiation_Homo sapiens_hsa047201.22901433
25Endometrial cancer_Homo sapiens_hsa052131.20250828
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18065685
27Estrogen signaling pathway_Homo sapiens_hsa049151.16286478
28Viral carcinogenesis_Homo sapiens_hsa052031.12699024
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12616536
30Non-small cell lung cancer_Homo sapiens_hsa052231.12443363
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.08347978
32Hepatitis C_Homo sapiens_hsa051601.06906697
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03956230
34Insulin secretion_Homo sapiens_hsa049111.03514328
35Insulin signaling pathway_Homo sapiens_hsa049101.03498049
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02707051
37ErbB signaling pathway_Homo sapiens_hsa040121.01973274
38Olfactory transduction_Homo sapiens_hsa047401.01881315
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00971732
40Apoptosis_Homo sapiens_hsa042100.99930858
41B cell receptor signaling pathway_Homo sapiens_hsa046620.99851090
42Circadian entrainment_Homo sapiens_hsa047130.99613887
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.98561201
44Glucagon signaling pathway_Homo sapiens_hsa049220.97641509
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97557752
46TNF signaling pathway_Homo sapiens_hsa046680.97393490
47Gastric acid secretion_Homo sapiens_hsa049710.95884274
48GnRH signaling pathway_Homo sapiens_hsa049120.94568706
49VEGF signaling pathway_Homo sapiens_hsa043700.93457872
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.92184537
51Influenza A_Homo sapiens_hsa051640.91854520
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91511621
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91467835
54Salivary secretion_Homo sapiens_hsa049700.91433203
55Choline metabolism in cancer_Homo sapiens_hsa052310.89830411
56Colorectal cancer_Homo sapiens_hsa052100.89559264
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.89408087
58AMPK signaling pathway_Homo sapiens_hsa041520.89401199
59Prion diseases_Homo sapiens_hsa050200.89196798
60Adherens junction_Homo sapiens_hsa045200.88875683
61Oxytocin signaling pathway_Homo sapiens_hsa049210.88671005
62Glutamatergic synapse_Homo sapiens_hsa047240.86537011
63Cholinergic synapse_Homo sapiens_hsa047250.86183249
64T cell receptor signaling pathway_Homo sapiens_hsa046600.85712543
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.85633901
66Prolactin signaling pathway_Homo sapiens_hsa049170.85239321
67Synaptic vesicle cycle_Homo sapiens_hsa047210.84861566
68GABAergic synapse_Homo sapiens_hsa047270.84529602
69Fatty acid biosynthesis_Homo sapiens_hsa000610.84516199
70Renal cell carcinoma_Homo sapiens_hsa052110.83515721
71Acute myeloid leukemia_Homo sapiens_hsa052210.83177240
72Proteoglycans in cancer_Homo sapiens_hsa052050.83009637
73Renin secretion_Homo sapiens_hsa049240.82957646
74Pancreatic cancer_Homo sapiens_hsa052120.82825278
75Notch signaling pathway_Homo sapiens_hsa043300.82446155
76Measles_Homo sapiens_hsa051620.81600459
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.81536979
78Inositol phosphate metabolism_Homo sapiens_hsa005620.81153883
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81020405
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.80818070
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80636141
82MicroRNAs in cancer_Homo sapiens_hsa052060.80325524
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80174063
84Morphine addiction_Homo sapiens_hsa050320.80113833
85Dopaminergic synapse_Homo sapiens_hsa047280.79446294
86Amoebiasis_Homo sapiens_hsa051460.78460348
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77699522
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76868487
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76690292
90Amphetamine addiction_Homo sapiens_hsa050310.74744823
91ABC transporters_Homo sapiens_hsa020100.74685836
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73449938
93cAMP signaling pathway_Homo sapiens_hsa040240.73160952
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.72660139
95HTLV-I infection_Homo sapiens_hsa051660.71799718
96Dilated cardiomyopathy_Homo sapiens_hsa054140.71413276
97MAPK signaling pathway_Homo sapiens_hsa040100.71059936
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70484304
99Ovarian steroidogenesis_Homo sapiens_hsa049130.69713929
100Gap junction_Homo sapiens_hsa045400.69586154
101PPAR signaling pathway_Homo sapiens_hsa033200.69089888
102Osteoclast differentiation_Homo sapiens_hsa043800.68159124
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67971455
104Pentose phosphate pathway_Homo sapiens_hsa000300.65149312
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64630762
106Alcoholism_Homo sapiens_hsa050340.64205089
107Viral myocarditis_Homo sapiens_hsa054160.62773527
108Rap1 signaling pathway_Homo sapiens_hsa040150.62510105
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61931016
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61583956
111Endocytosis_Homo sapiens_hsa041440.61391340
112Focal adhesion_Homo sapiens_hsa045100.61096286
113Cocaine addiction_Homo sapiens_hsa050300.60284644
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60129847
115FoxO signaling pathway_Homo sapiens_hsa040680.59930715
116Herpes simplex infection_Homo sapiens_hsa051680.59818213
117HIF-1 signaling pathway_Homo sapiens_hsa040660.59493544
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.59248373
119Shigellosis_Homo sapiens_hsa051310.59188550
120Fructose and mannose metabolism_Homo sapiens_hsa000510.59149942
121Systemic lupus erythematosus_Homo sapiens_hsa053220.58268489
122Pathways in cancer_Homo sapiens_hsa052000.57469114
123Small cell lung cancer_Homo sapiens_hsa052220.57160124
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56605344
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56501930
126Chemokine signaling pathway_Homo sapiens_hsa040620.55557470
127Melanoma_Homo sapiens_hsa052180.55442425
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55082312
129Lysosome_Homo sapiens_hsa041420.55034625
130Toxoplasmosis_Homo sapiens_hsa051450.54654668
131Thyroid hormone synthesis_Homo sapiens_hsa049180.54153248
132Prostate cancer_Homo sapiens_hsa052150.52614892
133Cell cycle_Homo sapiens_hsa041100.51112177
134Melanogenesis_Homo sapiens_hsa049160.51057875
135mRNA surveillance pathway_Homo sapiens_hsa030150.50228867
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48763395
137Platelet activation_Homo sapiens_hsa046110.47416968

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