AMD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1IMP biosynthetic process (GO:0006188)5.70749228
2IMP metabolic process (GO:0046040)5.42194570
3nucleobase biosynthetic process (GO:0046112)5.35995362
4purine nucleobase biosynthetic process (GO:0009113)5.24692249
5DNA unwinding involved in DNA replication (GO:0006268)4.60120801
6mitotic metaphase plate congression (GO:0007080)4.58739642
7nuclear pore organization (GO:0006999)4.57226358
8protein localization to kinetochore (GO:0034501)4.54851866
9regulation of translational termination (GO:0006449)4.50014377
10ribosome assembly (GO:0042255)4.38925806
11DNA replication initiation (GO:0006270)4.31577728
12nuclear pore complex assembly (GO:0051292)4.29904677
13folic acid-containing compound biosynthetic process (GO:0009396)4.18048221
14mitotic nuclear envelope disassembly (GO:0007077)4.17877474
15regulation of histone H3-K9 methylation (GO:0051570)4.13902108
16ribosome biogenesis (GO:0042254)4.04444653
17nuclear envelope disassembly (GO:0051081)4.01827171
18membrane disassembly (GO:0030397)4.01827171
19regulation of spindle organization (GO:0090224)3.96992989
20mitotic chromosome condensation (GO:0007076)3.92049307
21DNA strand elongation involved in DNA replication (GO:0006271)3.91729138
22metaphase plate congression (GO:0051310)3.83112524
23protein localization to chromosome, centromeric region (GO:0071459)3.78394920
24DNA strand elongation (GO:0022616)3.72383900
25DNA replication checkpoint (GO:0000076)3.69890763
26monoubiquitinated protein deubiquitination (GO:0035520)3.68214950
27CENP-A containing nucleosome assembly (GO:0034080)3.64872974
28DNA replication-dependent nucleosome assembly (GO:0006335)3.60142294
29DNA replication-dependent nucleosome organization (GO:0034723)3.60142294
30formation of translation preinitiation complex (GO:0001731)3.60124847
31chromatin remodeling at centromere (GO:0031055)3.58059894
32histone-serine phosphorylation (GO:0035404)3.57873673
33folic acid metabolic process (GO:0046655)3.50268423
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.47471348
35DNA replication-independent nucleosome organization (GO:0034724)3.42802581
36DNA replication-independent nucleosome assembly (GO:0006336)3.42802581
37positive regulation of histone H3-K4 methylation (GO:0051571)3.40266655
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39755555
39regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.32245803
40protein complex localization (GO:0031503)3.29112207
41establishment of chromosome localization (GO:0051303)3.29110293
42mitotic G2/M transition checkpoint (GO:0044818)3.28635055
43nuclear envelope organization (GO:0006998)3.27243015
44telomere maintenance via semi-conservative replication (GO:0032201)3.27067715
45establishment of integrated proviral latency (GO:0075713)3.26218405
46negative regulation of DNA repair (GO:0045738)3.25720424
47histone exchange (GO:0043486)3.25021836
48regulation of centrosome cycle (GO:0046605)3.24369757
49double-strand break repair via nonhomologous end joining (GO:0006303)3.22542604
50non-recombinational repair (GO:0000726)3.22542604
51regulation of helicase activity (GO:0051095)3.21630137
52attachment of spindle microtubules to kinetochore (GO:0008608)3.20464134
53nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.19482109
54regulation of mitotic spindle organization (GO:0060236)3.18032834
55definitive hemopoiesis (GO:0060216)3.16978679
56regulation of mitotic sister chromatid separation (GO:0010965)3.16438435
57regulation of mitotic sister chromatid segregation (GO:0033047)3.16438435
58regulation of sister chromatid segregation (GO:0033045)3.16438435
59rRNA methylation (GO:0031167)3.15175706
60regulation of centriole replication (GO:0046599)3.12356655
61negative regulation of histone methylation (GO:0031061)3.11259407
62DNA duplex unwinding (GO:0032508)3.10507845
63sister chromatid segregation (GO:0000819)3.09548881
64DNA geometric change (GO:0032392)3.09421220
65mitotic sister chromatid segregation (GO:0000070)3.09281134
66pore complex assembly (GO:0046931)3.08629481
67rRNA modification (GO:0000154)3.07395466
68mitotic G1 DNA damage checkpoint (GO:0031571)3.04807018
69cellular protein complex localization (GO:0034629)3.04647420
70regulation of RNA export from nucleus (GO:0046831)3.03168521
71mitotic sister chromatid cohesion (GO:0007064)3.02234793
72positive regulation of chromosome segregation (GO:0051984)3.01479761
73positive regulation of mitotic sister chromatid separation (GO:1901970)3.01102563
74positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.01102563
75positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.01102563
76ribonucleoprotein complex biogenesis (GO:0022613)3.00382968
77COPI coating of Golgi vesicle (GO:0048205)2.99949460
78Golgi transport vesicle coating (GO:0048200)2.99949460
79negative regulation of fibroblast apoptotic process (GO:2000270)2.99452671
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.96055660
81spindle checkpoint (GO:0031577)2.95358993
82sister chromatid cohesion (GO:0007062)2.94981590
83peptidyl-lysine dimethylation (GO:0018027)2.93499593
84mitochondrial RNA metabolic process (GO:0000959)2.92145182
85mitotic recombination (GO:0006312)2.91716293
86telomere maintenance via recombination (GO:0000722)2.90174062
87negative regulation of mRNA processing (GO:0050686)2.89610677
88negative regulation of mRNA metabolic process (GO:1903312)2.88557565
89regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88262790
90DNA synthesis involved in DNA repair (GO:0000731)2.86942038
91transcription from mitochondrial promoter (GO:0006390)2.85781482
92DNA topological change (GO:0006265)2.84700540
93histone mRNA metabolic process (GO:0008334)2.84196728
94regulation of chromosome segregation (GO:0051983)2.83796376
95protein K6-linked ubiquitination (GO:0085020)2.83346504
96response to X-ray (GO:0010165)2.82404049
97RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82112887
98spliceosomal snRNP assembly (GO:0000387)2.79612227
99mitotic spindle checkpoint (GO:0071174)2.79595242
100regulation of DNA methylation (GO:0044030)2.79057736
101chromatin assembly or disassembly (GO:0006333)2.78933464
102rRNA processing (GO:0006364)2.77838405
103mitotic G2 DNA damage checkpoint (GO:0007095)2.77703160
104regulation of DNA endoreduplication (GO:0032875)2.77409788
105pre-miRNA processing (GO:0031054)2.77073660
106pseudouridine synthesis (GO:0001522)2.77070830
107histone H2A monoubiquitination (GO:0035518)2.77043685
108protein localization to chromosome (GO:0034502)2.76924980
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76847930
110negative regulation of sister chromatid segregation (GO:0033046)2.76847930
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.76847930
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76847930
113L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.76559880
114maturation of SSU-rRNA (GO:0030490)2.76154111
115negative regulation of chromosome segregation (GO:0051985)2.75242046
116tRNA aminoacylation for protein translation (GO:0006418)2.74354413
117spindle assembly checkpoint (GO:0071173)2.74316967
118G1 DNA damage checkpoint (GO:0044783)2.74299084
119mitotic spindle assembly checkpoint (GO:0007094)2.74290905
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69384928
121rRNA metabolic process (GO:0016072)2.68358522
122tRNA aminoacylation (GO:0043039)2.67787588
123amino acid activation (GO:0043038)2.67787588
124negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67498150
125regulation of translational fidelity (GO:0006450)2.66916337
126cell cycle G1/S phase transition (GO:0044843)2.65350073
127G1/S transition of mitotic cell cycle (GO:0000082)2.65350073
128somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64746664
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.64746664
130histone phosphorylation (GO:0016572)2.64627686
131telomere maintenance via telomere lengthening (GO:0010833)2.62622848
132viral mRNA export from host cell nucleus (GO:0046784)2.62513927
133mRNA transport (GO:0051028)2.61090598
134kinetochore organization (GO:0051383)2.60729230
135regulation of mitotic metaphase/anaphase transition (GO:0030071)2.60434804
136GMP metabolic process (GO:0046037)2.59199549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.89013383
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.53774146
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.21373826
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83086874
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.77402113
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.11516034
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06444593
8* AR_21909140_ChIP-Seq_LNCAP_Human3.01929120
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98297812
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92487662
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87335180
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.82556287
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.74588748
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67125636
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.61317145
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.53509229
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.51546430
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50187531
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44904039
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.34128813
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28469153
22MYCN_18555785_ChIP-Seq_MESCs_Mouse2.26023937
23* XRN2_22483619_ChIP-Seq_HELA_Human2.22796728
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.18467094
25* VDR_23849224_ChIP-Seq_CD4+_Human2.11193328
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10194348
27NOTCH1_21737748_ChIP-Seq_TLL_Human2.07376979
28ZFX_18555785_ChIP-Seq_MESCs_Mouse2.06187794
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05790946
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98159008
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94843503
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94843503
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94843503
34DCP1A_22483619_ChIP-Seq_HELA_Human1.94226065
35GABP_19822575_ChIP-Seq_HepG2_Human1.92234080
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91200205
37ZNF263_19887448_ChIP-Seq_K562_Human1.89520955
38* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87299828
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83941473
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75339927
41KDM5A_27292631_Chip-Seq_BREAST_Human1.73258853
42FOXP3_21729870_ChIP-Seq_TREG_Human1.68744484
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65202434
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65064527
45* TTF2_22483619_ChIP-Seq_HELA_Human1.64145743
46ELK1_19687146_ChIP-ChIP_HELA_Human1.61951210
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60156187
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56489993
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54841937
50CIITA_25753668_ChIP-Seq_RAJI_Human1.54010468
51MYC_22102868_ChIP-Seq_BL_Human1.53394196
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53267124
53GATA1_22025678_ChIP-Seq_K562_Human1.51362151
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49572313
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49012091
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47967353
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47541424
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46475217
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31743388
60EWS_26573619_Chip-Seq_HEK293_Human1.31372786
61* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28830787
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27708876
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27604397
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.26407870
65* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26377270
66TFEB_21752829_ChIP-Seq_HELA_Human1.25952791
67SCL_19346495_ChIP-Seq_HPC-7_Human1.25194290
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22143828
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21669810
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20473576
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17324295
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15608445
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15336092
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.14680972
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14070223
76* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13867914
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13806810
78CHD1_26751641_Chip-Seq_LNCaP_Human1.13486473
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11975290
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11047704
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09665596
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08592047
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05933094
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04825887
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04144814
86* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02361984
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99907790
88SRF_21415370_ChIP-Seq_HL-1_Mouse0.99217798
89SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98813297
90FUS_26573619_Chip-Seq_HEK293_Human0.97103598
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95874693
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94159899
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.93698818
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.91629945
95MYC_18940864_ChIP-ChIP_HL60_Human0.91345622
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91123832
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90842251
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.89690449
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88951797
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88339998
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87120649
102TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86986577
103* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85512294
104EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84740159
105ATF3_27146783_Chip-Seq_COLON_Human0.83003697
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81153807
107* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80962812
108NANOG_16153702_ChIP-ChIP_HESCs_Human0.80920238
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.79481596
110IRF1_19129219_ChIP-ChIP_H3396_Human0.79186286
111SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79124927
112ELF5_23300383_ChIP-Seq_T47D_Human0.78746003
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78437979
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78215069
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.75890137
116TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75455046
117NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.75444767
118PKCTHETA_26484144_Chip-Seq_BREAST_Human0.74702154
119MYB_26560356_Chip-Seq_TH1_Human0.74442777
120FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.74259823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.12612237
2MP0004957_abnormal_blastocyst_morpholog4.22755801
3MP0010094_abnormal_chromosome_stability3.97530937
4MP0003111_abnormal_nucleus_morphology3.79294490
5MP0002009_preneoplasia3.33421068
6MP0003123_paternal_imprinting3.29954893
7MP0003077_abnormal_cell_cycle3.29795618
8MP0008057_abnormal_DNA_replication3.05987562
9MP0008007_abnormal_cellular_replicative2.80922986
10MP0004145_abnormal_muscle_electrophysio2.63964569
11* MP0001730_embryonic_growth_arrest2.47478772
12MP0000350_abnormal_cell_proliferation2.30376068
13MP0008058_abnormal_DNA_repair2.20748197
14MP0000747_muscle_weakness2.10964511
15MP0003941_abnormal_skin_development2.09482599
16MP0010352_gastrointestinal_tract_polyps2.08903831
17MP0010307_abnormal_tumor_latency2.08110065
18MP0004147_increased_porphyrin_level2.07048882
19MP0009697_abnormal_copulation2.05664863
20MP0004233_abnormal_muscle_weight2.02152001
21MP0010234_abnormal_vibrissa_follicle2.01342063
22MP0002396_abnormal_hematopoietic_system2.00598158
23MP0002166_altered_tumor_susceptibility1.94945117
24MP0000749_muscle_degeneration1.94392073
25MP0008932_abnormal_embryonic_tissue1.88963397
26MP0002006_tumorigenesis1.87801119
27MP0001697_abnormal_embryo_size1.82272449
28MP0003646_muscle_fatigue1.82084460
29MP0002269_muscular_atrophy1.78439509
30MP0001672_abnormal_embryogenesis/_devel1.73166372
31MP0005380_embryogenesis_phenotype1.73166372
32MP0000537_abnormal_urethra_morphology1.70069810
33MP0004036_abnormal_muscle_relaxation1.67365533
34* MP0002080_prenatal_lethality1.61209660
35MP0000751_myopathy1.61101121
36MP0003984_embryonic_growth_retardation1.60114855
37MP0002088_abnormal_embryonic_growth/wei1.54993236
38MP0000750_abnormal_muscle_regeneration1.54715719
39MP0002084_abnormal_developmental_patter1.50885925
40MP0008877_abnormal_DNA_methylation1.50206634
41MP0002085_abnormal_embryonic_tissue1.49689646
42MP0003221_abnormal_cardiomyocyte_apopto1.47345263
43MP0003656_abnormal_erythrocyte_physiolo1.44868250
44MP0004084_abnormal_cardiac_muscle1.43976756
45MP0002106_abnormal_muscle_physiology1.42560425
46MP0004197_abnormal_fetal_growth/weight/1.42273931
47MP0001485_abnormal_pinna_reflex1.41150889
48MP0005647_abnormal_sex_gland1.40864533
49MP0002086_abnormal_extraembryonic_tissu1.34328023
50MP0003950_abnormal_plasma_membrane1.32750853
51MP0003786_premature_aging1.32229827
52MP0006054_spinal_hemorrhage1.30024098
53MP0009672_abnormal_birth_weight1.29801253
54MP0005464_abnormal_platelet_physiology1.29371328
55MP0002877_abnormal_melanocyte_morpholog1.26648312
56MP0003315_abnormal_perineum_morphology1.23130047
57MP0006036_abnormal_mitochondrial_physio1.19984287
58MP0000759_abnormal_skeletal_muscle1.17886221
59MP0004087_abnormal_muscle_fiber1.17797426
60MP0003806_abnormal_nucleotide_metabolis1.16997362
61MP0002796_impaired_skin_barrier1.16776285
62MP0003567_abnormal_fetal_cardiomyocyte1.16214178
63MP0005369_muscle_phenotype1.14993304
64MP0004043_abnormal_pH_regulation1.13665971
65MP0005076_abnormal_cell_differentiation1.13479601
66MP0004264_abnormal_extraembryonic_tissu1.12335196
67MP0000313_abnormal_cell_death1.12070501
68MP0000733_abnormal_muscle_development1.12020223
69MP0004215_abnormal_myocardial_fiber1.10899733
70MP0003705_abnormal_hypodermis_morpholog1.09554580
71MP0000490_abnormal_crypts_of1.08740017
72MP0003718_maternal_effect1.07496102
73MP0004808_abnormal_hematopoietic_stem1.02228968
74MP0005395_other_phenotype1.01943275
75MP0002019_abnormal_tumor_incidence0.97342740
76MP0005620_abnormal_muscle_contractility0.97068514
77MP0003121_genomic_imprinting0.96814299
78MP0003699_abnormal_female_reproductive0.93324163
79MP0000358_abnormal_cell_content/0.92719897
80MP0003937_abnormal_limbs/digits/tail_de0.91475593
81MP0006072_abnormal_retinal_apoptosis0.91276687
82MP0001145_abnormal_male_reproductive0.90190169
83MP0003890_abnormal_embryonic-extraembry0.88819171
84MP0002398_abnormal_bone_marrow0.88455509
85MP0000627_abnormal_mammary_gland0.87121846
86MP0009703_decreased_birth_body0.86978128
87MP0005330_cardiomyopathy0.86569709
88MP0002210_abnormal_sex_determination0.85566769
89MP0005384_cellular_phenotype0.85144344
90MP0000653_abnormal_sex_gland0.84502269
91MP0005666_abnormal_adipose_tissue0.84318833
92MP0005187_abnormal_penis_morphology0.82912719
93MP0001293_anophthalmia0.82868927
94MP0000703_abnormal_thymus_morphology0.82821568
95MP0006035_abnormal_mitochondrial_morpho0.82613283
96MP0000428_abnormal_craniofacial_morphol0.82580038
97MP0001188_hyperpigmentation0.82035582
98MP0005501_abnormal_skin_physiology0.81725299
99MP0005621_abnormal_cell_physiology0.81236632
100MP0005220_abnormal_exocrine_pancreas0.81099514
101MP0001929_abnormal_gametogenesis0.78490449
102MP0004185_abnormal_adipocyte_glucose0.77494853
103MP0010678_abnormal_skin_adnexa0.76157828
104MP0002160_abnormal_reproductive_system0.75158665
105MP0008961_abnormal_basal_metabolism0.74485155
106MP0002653_abnormal_ependyma_morphology0.71679336
107MP0001881_abnormal_mammary_gland0.71187110
108MP0008260_abnormal_autophagy0.71107208
109MP0004885_abnormal_endolymph0.70164729
110MP0002837_dystrophic_cardiac_calcinosis0.67937469
111MP0002111_abnormal_tail_morphology0.67549943
112MP0010030_abnormal_orbit_morphology0.66953034
113MP0005310_abnormal_salivary_gland0.66917158
114MP0000689_abnormal_spleen_morphology0.66797105
115MP0005389_reproductive_system_phenotype0.66136945
116MP0002722_abnormal_immune_system0.66030405
117MP0005266_abnormal_metabolism0.64713039
118MP0001849_ear_inflammation0.62634768
119MP0001119_abnormal_female_reproductive0.60846201
120MP0002161_abnormal_fertility/fecundity0.60305327
121MP0001853_heart_inflammation0.59967042
122MP0005397_hematopoietic_system_phenotyp0.59952584
123MP0001545_abnormal_hematopoietic_system0.59952584
124MP0000465_gastrointestinal_hemorrhage0.59310282
125MP0004484_altered_response_of0.59274960
126MP0003698_abnormal_male_reproductive0.59062100
127MP0006292_abnormal_olfactory_placode0.58333706
128MP0001191_abnormal_skin_condition0.58233825
129MP0003763_abnormal_thymus_physiology0.57387710
130MP0000266_abnormal_heart_morphology0.57008301
131MP0001299_abnormal_eye_distance/0.56865882
132MP0003119_abnormal_digestive_system0.55904304
133MP0002429_abnormal_blood_cell0.54338366
134MP0000598_abnormal_liver_morphology0.53321937
135MP0003943_abnormal_hepatobiliary_system0.52578414
136MP0010630_abnormal_cardiac_muscle0.51904483

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.43673965
2Exercise-induced muscle cramps (HP:0003710)4.32055536
3Chromsome breakage (HP:0040012)4.25260774
4Birth length less than 3rd percentile (HP:0003561)3.95793377
5Shoulder girdle muscle weakness (HP:0003547)3.90711657
6Pelvic girdle muscle weakness (HP:0003749)3.82433140
7Acute myeloid leukemia (HP:0004808)3.76140533
8Muscle fiber inclusion bodies (HP:0100299)3.59485896
9Abnormality of the calcaneus (HP:0008364)3.58086985
10Ulnar deviation of the wrist (HP:0003049)3.50399381
11Calcaneovalgus deformity (HP:0001848)3.49797006
12Reduced antithrombin III activity (HP:0001976)3.48493289
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.42752017
14Abnormality of the musculature of the pelvis (HP:0001469)3.40319493
15Abnormality of the hip-girdle musculature (HP:0001445)3.40319493
16Deformed tarsal bones (HP:0008119)3.29946112
17Nephroblastoma (Wilms tumor) (HP:0002667)3.24513794
18Dyschromatopsia (HP:0007641)3.24419907
19Rimmed vacuoles (HP:0003805)3.18452668
20Myelodysplasia (HP:0002863)3.18063305
21Embryonal renal neoplasm (HP:0011794)3.17296761
22Carpal bone hypoplasia (HP:0001498)3.16999133
23Multiple enchondromatosis (HP:0005701)3.16741332
24Cerebral hypomyelination (HP:0006808)3.13561784
25Nemaline bodies (HP:0003798)3.13088653
26Abnormality of chromosome stability (HP:0003220)3.12345364
27Distal arthrogryposis (HP:0005684)3.10300719
28Volvulus (HP:0002580)3.06590328
29Progressive muscle weakness (HP:0003323)2.94474869
30Abnormality of the preputium (HP:0100587)2.89806167
31Exercise-induced myalgia (HP:0003738)2.89058277
32Rhabdomyosarcoma (HP:0002859)2.88025318
33Central scotoma (HP:0000603)2.87138996
34Prostate neoplasm (HP:0100787)2.87005098
35Breast hypoplasia (HP:0003187)2.85270903
36Muscle fiber splitting (HP:0003555)2.81804089
37Capillary hemangiomas (HP:0005306)2.81272845
38Degeneration of anterior horn cells (HP:0002398)2.77185621
39Abnormality of the anterior horn cell (HP:0006802)2.77185621
40Abnormality of cochlea (HP:0000375)2.70504943
41Acute lymphatic leukemia (HP:0006721)2.69730720
42Meckel diverticulum (HP:0002245)2.64745514
43Papillary thyroid carcinoma (HP:0002895)2.62688688
44Colon cancer (HP:0003003)2.61776471
45Rhabdomyolysis (HP:0003201)2.61429890
46Gonadotropin excess (HP:0000837)2.59751491
47Ependymoma (HP:0002888)2.55162868
48Abnormality of methionine metabolism (HP:0010901)2.52263380
49Limb-girdle muscle weakness (HP:0003325)2.49028676
50Myopathic facies (HP:0002058)2.48193869
51Abnormality of the ileum (HP:0001549)2.48121141
52CNS hypomyelination (HP:0003429)2.47027986
53Abnormality of alanine metabolism (HP:0010916)2.46766985
54Hyperalaninemia (HP:0003348)2.46766985
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46766985
56Biliary tract neoplasm (HP:0100574)2.43867726
57Postnatal microcephaly (HP:0005484)2.42286462
58Small intestinal stenosis (HP:0012848)2.40650965
59Duodenal stenosis (HP:0100867)2.40650965
60Abnormality of the labia minora (HP:0012880)2.38570168
61Oral leukoplakia (HP:0002745)2.38090723
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.36809853
63Deviation of the thumb (HP:0009603)2.36111146
64Progressive external ophthalmoplegia (HP:0000590)2.36072150
65Abnormal spermatogenesis (HP:0008669)2.35567981
66Microvesicular hepatic steatosis (HP:0001414)2.35230873
67Irregular epiphyses (HP:0010582)2.34858450
68Myoglobinuria (HP:0002913)2.33005807
69Pancreatic islet-cell hyperplasia (HP:0004510)2.31601640
7011 pairs of ribs (HP:0000878)2.31355475
71Absent radius (HP:0003974)2.31255660
72Abnormality of the proximal phalanges of the hand (HP:0009834)2.30920803
73Aplastic anemia (HP:0001915)2.28980740
74Proximal placement of thumb (HP:0009623)2.27705812
75Azoospermia (HP:0000027)2.27425716
76Rough bone trabeculation (HP:0100670)2.25510244
77Difficulty climbing stairs (HP:0003551)2.23510163
78Neoplasm of the pancreas (HP:0002894)2.22542259
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.21746335
80Muscle hypertrophy of the lower extremities (HP:0008968)2.19855110
81Aplasia/Hypoplasia of the sternum (HP:0006714)2.19181381
82Short middle phalanx of the 5th finger (HP:0004220)2.19067932
83Abnormality of homocysteine metabolism (HP:0010919)2.18478132
84Homocystinuria (HP:0002156)2.18478132
85Abnormality of the pons (HP:0007361)2.18248192
86Dysmetric saccades (HP:0000641)2.17692607
87Abnormal lung lobation (HP:0002101)2.15898979
88Abnormality of the intrinsic pathway (HP:0010989)2.15567899
89Limb-girdle muscle atrophy (HP:0003797)2.14078838
90Abnormality of secondary sexual hair (HP:0009888)2.13798746
91Abnormality of the axillary hair (HP:0100134)2.13798746
92Sparse lateral eyebrow (HP:0005338)2.13759328
93Type 1 muscle fiber predominance (HP:0003803)2.13699019
94Amaurosis fugax (HP:0100576)2.13289596
95Selective tooth agenesis (HP:0001592)2.12592242
96Round ear (HP:0100830)2.11571674
97Hypoplasia of the pons (HP:0012110)2.10794705
98Abnormal number of erythroid precursors (HP:0012131)2.10589048
99Missing ribs (HP:0000921)2.09601690
100Malignant gastrointestinal tract tumors (HP:0006749)2.09018350
101Gastrointestinal carcinoma (HP:0002672)2.09018350
102Abnormality of the prostate (HP:0008775)2.06853808
103Absent forearm bone (HP:0003953)2.06264178
104Aplasia involving forearm bones (HP:0009822)2.06264178
105Neoplasm of the colon (HP:0100273)2.06049596
106Fibular aplasia (HP:0002990)2.05767723
107Increased nuchal translucency (HP:0010880)2.05384512
108Abnormality of cells of the erythroid lineage (HP:0012130)2.04822780
109Cafe-au-lait spot (HP:0000957)2.00887869
110Clitoromegaly (HP:0000057)1.96704686
111Spastic diplegia (HP:0001264)1.96652524
112Uterine neoplasm (HP:0010784)1.96235707
113Aplasia/Hypoplasia of the patella (HP:0006498)1.95224988
114Abnormality of the duodenum (HP:0002246)1.94884612
115Increased connective tissue (HP:0009025)1.94408501
116Clubbing of toes (HP:0100760)1.93742444
117Agnosia (HP:0010524)1.93350907
118Hypoglycemic coma (HP:0001325)1.93244787
119Ectopic kidney (HP:0000086)1.92524303
120Embryonal neoplasm (HP:0002898)1.92294535
121Cutaneous melanoma (HP:0012056)1.91478728
122Resting tremor (HP:0002322)1.91136798
123Deep philtrum (HP:0002002)1.91018083
124Autoimmune hemolytic anemia (HP:0001890)1.90427953
125Protruding tongue (HP:0010808)1.90282714
126Thyroid carcinoma (HP:0002890)1.89928461
127Abnormal biliary tract morphology (HP:0012440)1.88750597
128Sensory axonal neuropathy (HP:0003390)1.88495606
129Glossoptosis (HP:0000162)1.88330824
130Choanal atresia (HP:0000453)1.87983877
131Facial hemangioma (HP:0000329)1.86788832
132Calf muscle hypertrophy (HP:0008981)1.86273344
133Abnormal auditory evoked potentials (HP:0006958)1.86193726
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85998616
135Abnormal protein N-linked glycosylation (HP:0012347)1.85998616
136Abnormal protein glycosylation (HP:0012346)1.85998616
137Abnormal glycosylation (HP:0012345)1.85998616
138Scotoma (HP:0000575)1.85996190
139Neoplasm of the rectum (HP:0100743)1.85572396
140Anal stenosis (HP:0002025)1.84045579
141Absent phalangeal crease (HP:0006109)1.82959961
142Medulloblastoma (HP:0002885)1.82625651
143Areflexia of lower limbs (HP:0002522)1.80986534
144Syringomyelia (HP:0003396)1.80863735
145Spinal cord lesions (HP:0100561)1.80863735
146Entropion (HP:0000621)1.79855956
147Stenosis of the external auditory canal (HP:0000402)1.79621751
148Glioma (HP:0009733)1.79543302
149Leiomyosarcoma (HP:0100243)1.79361114
150Uterine leiomyosarcoma (HP:0002891)1.79361114
151Ankyloglossia (HP:0010296)1.79211269
152Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78292131
153Neoplasm of the small intestine (HP:0100833)1.78034411
154Morphological abnormality of the inner ear (HP:0011390)1.77727769
155Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77432812
156Megaloblastic anemia (HP:0001889)1.76915359
157Difficulty running (HP:0009046)1.76374717
158Increased density of long bones (HP:0006392)1.75470724
159Patellar aplasia (HP:0006443)1.74590364
160Posterior subcapsular cataract (HP:0007787)1.74317257
161Basal cell carcinoma (HP:0002671)1.72144416
162EMG: myopathic abnormalities (HP:0003458)1.71874536
163Gout (HP:0001997)1.70211184
164Achilles tendon contracture (HP:0001771)1.69585357
165Ovarian neoplasm (HP:0100615)1.68398776
166Unsteady gait (HP:0002317)1.68208619
167Microretrognathia (HP:0000308)1.68028371
168Broad distal phalanx of finger (HP:0009836)1.67736643
169Impulsivity (HP:0100710)1.67260031
170Abnormality of the shoulder girdle musculature (HP:0001435)1.65944742
171Slender long bone (HP:0003100)1.65350893
172Congenital stationary night blindness (HP:0007642)1.65024480
173Abnormality of subcutaneous fat tissue (HP:0001001)1.64552255
174Muscle stiffness (HP:0003552)1.60136057
175Subaortic stenosis (HP:0001682)1.60065532
176Abnormality of the left ventricular outflow tract (HP:0011103)1.60065532
177Neck muscle weakness (HP:0000467)1.59866633
178Short palpebral fissure (HP:0012745)1.58317716
179Metaphyseal cupping (HP:0003021)1.56933787
180Abnormality of the astrocytes (HP:0100707)1.56607431
181Astrocytoma (HP:0009592)1.56607431
182Long clavicles (HP:0000890)1.56600026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.70593431
2CDC73.70349681
3BUB13.47265011
4NEK13.46630373
5PBK2.97943950
6BRSK22.54985686
7SCYL22.54102959
8TSSK62.48230833
9TAF12.46231779
10NEK22.41287066
11CDK122.32364802
12EIF2AK12.22691550
13CAMK1D2.20350981
14LATS12.17465018
15PLK42.09369894
16TTN2.08489175
17NME12.00505346
18MKNK11.99846150
19SRPK11.97851835
20TTK1.97840489
21EEF2K1.96321674
22PLK31.88946056
23CAMK1G1.76509559
24PASK1.68747099
25BRSK11.66988943
26RPS6KB21.61492663
27CCNB11.54737548
28NUAK11.49654224
29PKN21.46614350
30PLK11.46259995
31MAP2K31.45264847
32PDK41.45208447
33PDK31.45208447
34FLT31.44603310
35TEC1.42666893
36MAP3K81.42612073
37OBSCN1.39965833
38EIF2AK31.39893450
39MKNK21.36297273
40ACVR1B1.34958424
41AURKB1.29391856
42SMG11.28355638
43TESK21.23667091
44EPHA21.21495564
45MAP3K131.18564720
46AKT31.11966614
47RPS6KA41.08628217
48CHEK11.08597049
49STK38L1.08148032
50EIF2AK21.07960498
51STK31.05911364
52MAP3K31.04542389
53ATR1.02905600
54STK390.97700488
55KSR20.96544752
56CHEK20.95848440
57TRIB30.95254556
58CDK40.94595456
59ALK0.94561663
60RAF10.91415900
61CDK90.91253045
62VRK10.90909206
63BCKDK0.88078818
64OXSR10.87290015
65PDK20.86305045
66MELK0.86151492
67AURKA0.84838764
68CDK190.82826883
69STK40.82349030
70NME20.81560791
71DYRK30.81513295
72PNCK0.75087705
73CDK70.74100357
74PIM10.73140129
75TRIM280.72967127
76TNK20.72175469
77CDK20.69174829
78PHKG20.68801900
79PHKG10.68801900
80MAPKAPK30.67478756
81TNIK0.67302224
82ATM0.66709735
83NEK60.66608129
84STK100.65769235
85ERBB30.65042599
86LATS20.64231899
87INSRR0.64022728
88NEK90.63923079
89TAOK30.63409847
90PRKD30.62727776
91ERBB40.62418038
92PAK40.61198374
93FRK0.60257991
94VRK20.59212254
95IRAK20.58612853
96WNK10.58185601
97MAP3K90.57540263
98CDK30.53208426
99BRAF0.52280212
100ZAK0.52071239
101DAPK10.51885099
102MAP3K140.51664173
103TGFBR10.50575009
104CDK10.50345169
105PLK20.49413267
106BMPR20.49284695
107LRRK20.48487598
108YES10.47042630
109BMPR1B0.46326922
110CSNK2A20.45263686
111CDK60.43634991
112KSR10.42065318
113PAK20.41628739
114CSNK1E0.40636587
115PRPF4B0.40587880
116PRKDC0.39123368
117LMTK20.38932983
118STK160.36541256
119PINK10.36324733
120PAK10.35904949
121TAOK10.35551905
122MAP3K20.35206265
123MAPK100.35005576
124AKT20.34940709
125BRD40.32813138
126PRKCI0.32543570
127MAP3K50.31481509
128MAP3K40.31418511
129MST40.30604280
130NLK0.30430473
131RPS6KB10.30382256
132FGFR10.28421744
133STK240.28407636
134IRAK10.27192102
135CSNK1G10.27147563
136CSNK1A1L0.26650809
137CSNK2A10.26477097

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.17718248
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.12056536
3RNA transport_Homo sapiens_hsa030133.45659402
4Mismatch repair_Homo sapiens_hsa034303.38771762
5RNA polymerase_Homo sapiens_hsa030203.13197380
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.94326939
7Spliceosome_Homo sapiens_hsa030402.83980361
8Cell cycle_Homo sapiens_hsa041102.80813927
9Nucleotide excision repair_Homo sapiens_hsa034202.47367084
10Base excision repair_Homo sapiens_hsa034102.32383648
11One carbon pool by folate_Homo sapiens_hsa006702.29939364
12Vitamin B6 metabolism_Homo sapiens_hsa007502.26846869
13Homologous recombination_Homo sapiens_hsa034401.95349277
14RNA degradation_Homo sapiens_hsa030181.95264369
15Proteasome_Homo sapiens_hsa030501.91820323
16mRNA surveillance pathway_Homo sapiens_hsa030151.90073978
17Pyrimidine metabolism_Homo sapiens_hsa002401.86236417
18Oocyte meiosis_Homo sapiens_hsa041141.82739381
19Non-homologous end-joining_Homo sapiens_hsa034501.76740867
20Basal transcription factors_Homo sapiens_hsa030221.73283170
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72306065
22Biosynthesis of amino acids_Homo sapiens_hsa012301.65619639
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54687387
24Purine metabolism_Homo sapiens_hsa002301.52001073
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46753992
26Thyroid cancer_Homo sapiens_hsa052161.36852068
27Ribosome_Homo sapiens_hsa030101.33930169
28Protein export_Homo sapiens_hsa030601.32498903
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25251330
30Fatty acid biosynthesis_Homo sapiens_hsa000611.24585141
31Propanoate metabolism_Homo sapiens_hsa006401.19963740
32Pentose phosphate pathway_Homo sapiens_hsa000301.19864344
33Fanconi anemia pathway_Homo sapiens_hsa034601.19467838
34p53 signaling pathway_Homo sapiens_hsa041151.18966007
35* Cysteine and methionine metabolism_Homo sapiens_hsa002701.18425563
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14195234
37Carbon metabolism_Homo sapiens_hsa012001.02676764
38mTOR signaling pathway_Homo sapiens_hsa041500.95627118
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94278707
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93285169
41Circadian rhythm_Homo sapiens_hsa047100.91183755
42Viral carcinogenesis_Homo sapiens_hsa052030.89681634
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89625967
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89493991
45Systemic lupus erythematosus_Homo sapiens_hsa053220.88521783
46Selenocompound metabolism_Homo sapiens_hsa004500.87529418
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86911281
48N-Glycan biosynthesis_Homo sapiens_hsa005100.83264999
49Epstein-Barr virus infection_Homo sapiens_hsa051690.77917278
50Fatty acid elongation_Homo sapiens_hsa000620.77649496
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.77377258
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75273542
53Lysine degradation_Homo sapiens_hsa003100.72961349
54Folate biosynthesis_Homo sapiens_hsa007900.72645553
55Vitamin digestion and absorption_Homo sapiens_hsa049770.72390797
56Phototransduction_Homo sapiens_hsa047440.72320582
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71936346
58Steroid biosynthesis_Homo sapiens_hsa001000.67915702
59Legionellosis_Homo sapiens_hsa051340.67622582
60Alcoholism_Homo sapiens_hsa050340.66851143
61Fructose and mannose metabolism_Homo sapiens_hsa000510.66046152
62Hippo signaling pathway_Homo sapiens_hsa043900.65315878
63Long-term potentiation_Homo sapiens_hsa047200.62924973
64Tight junction_Homo sapiens_hsa045300.61735253
65Platelet activation_Homo sapiens_hsa046110.61425600
66TGF-beta signaling pathway_Homo sapiens_hsa043500.57152475
67Adherens junction_Homo sapiens_hsa045200.56349379
68MicroRNAs in cancer_Homo sapiens_hsa052060.54288050
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52674706
70Acute myeloid leukemia_Homo sapiens_hsa052210.51180499
71Fatty acid metabolism_Homo sapiens_hsa012120.50426507
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.50000412
73HTLV-I infection_Homo sapiens_hsa051660.49856075
74Small cell lung cancer_Homo sapiens_hsa052220.49493522
75HIF-1 signaling pathway_Homo sapiens_hsa040660.49045298
76Insulin signaling pathway_Homo sapiens_hsa049100.48249453
77Pancreatic cancer_Homo sapiens_hsa052120.47127311
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45986974
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44989876
80Non-small cell lung cancer_Homo sapiens_hsa052230.44617532
81Pancreatic secretion_Homo sapiens_hsa049720.43978712
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42517230
83Glucagon signaling pathway_Homo sapiens_hsa049220.42442251
84Galactose metabolism_Homo sapiens_hsa000520.42061964
85Bladder cancer_Homo sapiens_hsa052190.40544946
86AMPK signaling pathway_Homo sapiens_hsa041520.40459113
87Hepatitis B_Homo sapiens_hsa051610.39947277
88FoxO signaling pathway_Homo sapiens_hsa040680.37216447
89Regulation of autophagy_Homo sapiens_hsa041400.36479461
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35605246
91Oxytocin signaling pathway_Homo sapiens_hsa049210.34919746
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32786815
93Inositol phosphate metabolism_Homo sapiens_hsa005620.31549039
94Apoptosis_Homo sapiens_hsa042100.31398582
95Chronic myeloid leukemia_Homo sapiens_hsa052200.31168327
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31022037
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30355891
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28570489
99Antigen processing and presentation_Homo sapiens_hsa046120.28249015
100Renin-angiotensin system_Homo sapiens_hsa046140.28202840
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27721461
102B cell receptor signaling pathway_Homo sapiens_hsa046620.27321977
103Glioma_Homo sapiens_hsa052140.26539317
104Herpes simplex infection_Homo sapiens_hsa051680.26504854
105Prostate cancer_Homo sapiens_hsa052150.25646232
106Colorectal cancer_Homo sapiens_hsa052100.25611062
107Measles_Homo sapiens_hsa051620.25578446
108Ovarian steroidogenesis_Homo sapiens_hsa049130.25345573
109Endometrial cancer_Homo sapiens_hsa052130.25105689
110Dilated cardiomyopathy_Homo sapiens_hsa054140.24727542
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24626882
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23483698
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23304209
114Amphetamine addiction_Homo sapiens_hsa050310.22869870
115Gap junction_Homo sapiens_hsa045400.22672778
116Thyroid hormone synthesis_Homo sapiens_hsa049180.22601716
117Melanoma_Homo sapiens_hsa052180.22056614
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22020726
119Renal cell carcinoma_Homo sapiens_hsa052110.21491922
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21361262
121Pyruvate metabolism_Homo sapiens_hsa006200.19689037
122Wnt signaling pathway_Homo sapiens_hsa043100.19684735
123Proteoglycans in cancer_Homo sapiens_hsa052050.17479159
124Long-term depression_Homo sapiens_hsa047300.17394582
125Insulin resistance_Homo sapiens_hsa049310.17232786
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15262436
127Estrogen signaling pathway_Homo sapiens_hsa049150.14857488
128Glutathione metabolism_Homo sapiens_hsa004800.14673033
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.14034283
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13771172
131Shigellosis_Homo sapiens_hsa051310.13642380
132Dopaminergic synapse_Homo sapiens_hsa047280.12573465

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