

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 9.66260278 |
| 2 | negative regulation of cAMP-mediated signaling (GO:0043951) | 8.79239796 |
| 3 | opioid receptor signaling pathway (GO:0038003) | 8.60918482 |
| 4 | behavioral response to ethanol (GO:0048149) | 7.56260024 |
| 5 | regulation of protein glycosylation (GO:0060049) | 6.60605047 |
| 6 | adult feeding behavior (GO:0008343) | 6.51494157 |
| 7 | regulation of translational termination (GO:0006449) | 6.46571731 |
| 8 | negative regulation of calcium ion-dependent exocytosis (GO:0045955) | 6.39371337 |
| 9 | ether lipid metabolic process (GO:0046485) | 6.37809766 |
| 10 | regulation of acrosome reaction (GO:0060046) | 6.18025753 |
| 11 | relaxation of smooth muscle (GO:0044557) | 5.83982221 |
| 12 | protein-chromophore linkage (GO:0018298) | 5.62004714 |
| 13 | positive regulation of cAMP-mediated signaling (GO:0043950) | 5.39924110 |
| 14 | notochord development (GO:0030903) | 5.08010196 |
| 15 | multicellular organismal reproductive behavior (GO:0033057) | 5.07044072 |
| 16 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 5.05298393 |
| 17 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 4.98970642 |
| 18 | piRNA metabolic process (GO:0034587) | 4.80854653 |
| 19 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.79848114 |
| 20 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.79848114 |
| 21 | glomerular visceral epithelial cell development (GO:0072015) | 4.70838805 |
| 22 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 4.40628583 |
| 23 | transmission of nerve impulse (GO:0019226) | 4.28211465 |
| 24 | sphingosine metabolic process (GO:0006670) | 4.15386975 |
| 25 | N-terminal protein amino acid acetylation (GO:0006474) | 4.14260026 |
| 26 | glomerular epithelial cell development (GO:0072310) | 4.09909453 |
| 27 | meiotic chromosome segregation (GO:0045132) | 4.08526365 |
| 28 | thrombin receptor signaling pathway (GO:0070493) | 4.07523233 |
| 29 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.05481734 |
| 30 | ncRNA catabolic process (GO:0034661) | 4.02350871 |
| 31 | negative regulation of adenylate cyclase activity (GO:0007194) | 4.01391471 |
| 32 | proline biosynthetic process (GO:0006561) | 3.96831164 |
| 33 | cellular response to ammonium ion (GO:0071242) | 3.84272851 |
| 34 | negative regulation of myotube differentiation (GO:0010832) | 3.84008720 |
| 35 | negative regulation of cyclase activity (GO:0031280) | 3.80914525 |
| 36 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.72615786 |
| 37 | diol metabolic process (GO:0034311) | 3.67915594 |
| 38 | regulation of rhodopsin mediated signaling pathway (GO:0022400) | 3.67189102 |
| 39 | negative regulation of lyase activity (GO:0051350) | 3.63853655 |
| 40 | sphingoid metabolic process (GO:0046519) | 3.62336272 |
| 41 | glomerular basement membrane development (GO:0032836) | 3.56699179 |
| 42 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.49669117 |
| 43 | regulation of memory T cell differentiation (GO:0043380) | 3.45985199 |
| 44 | glycerol ether metabolic process (GO:0006662) | 3.42268098 |
| 45 | nephron tubule formation (GO:0072079) | 3.42047878 |
| 46 | mRNA cleavage (GO:0006379) | 3.40966546 |
| 47 | indolalkylamine metabolic process (GO:0006586) | 3.32811560 |
| 48 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 3.30988179 |
| 49 | rhodopsin mediated signaling pathway (GO:0016056) | 3.29353640 |
| 50 | detection of chemical stimulus involved in sensory perception of smell (GO:0050911) | 3.28351116 |
| 51 | multi-organism reproductive behavior (GO:0044705) | 3.23653033 |
| 52 | coenzyme catabolic process (GO:0009109) | 3.20518608 |
| 53 | reproductive behavior (GO:0019098) | 3.18701919 |
| 54 | cellular response to alkaloid (GO:0071312) | 3.18134893 |
| 55 | ether metabolic process (GO:0018904) | 3.14403620 |
| 56 | regulation of ER to Golgi vesicle-mediated transport (GO:0060628) | 3.13101984 |
| 57 | drug catabolic process (GO:0042737) | 3.12657185 |
| 58 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.11152225 |
| 59 | regulation of cAMP-mediated signaling (GO:0043949) | 3.11127513 |
| 60 | regulation of transcription initiation from RNA polymerase II promoter (GO:0060260) | 3.09794012 |
| 61 | microtubule severing (GO:0051013) | 3.09646522 |
| 62 | negative regulation of glycoprotein biosynthetic process (GO:0010561) | 3.07175009 |
| 63 | dopamine receptor signaling pathway (GO:0007212) | 3.02042358 |
| 64 | proline metabolic process (GO:0006560) | 2.98586486 |
| 65 | cornea development in camera-type eye (GO:0061303) | 2.96621265 |
| 66 | regulation of T cell receptor signaling pathway (GO:0050856) | 2.90887856 |
| 67 | lung epithelial cell differentiation (GO:0060487) | 2.88411177 |
| 68 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.86340558 |
| 69 | cell-cell junction maintenance (GO:0045217) | 2.86229992 |
| 70 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.85221260 |
| 71 | urate metabolic process (GO:0046415) | 2.82055439 |
| 72 | dopamine transport (GO:0015872) | 2.81196964 |
| 73 | UMP biosynthetic process (GO:0006222) | 2.80694173 |
| 74 | pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174) | 2.80694173 |
| 75 | UMP metabolic process (GO:0046049) | 2.80694173 |
| 76 | pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173) | 2.80694173 |
| 77 | negative regulation of cAMP biosynthetic process (GO:0030818) | 2.76894084 |
| 78 | tachykinin receptor signaling pathway (GO:0007217) | 2.75715797 |
| 79 | vitamin catabolic process (GO:0009111) | 2.74192656 |
| 80 | fat-soluble vitamin catabolic process (GO:0042363) | 2.74192656 |
| 81 | DNA strand renaturation (GO:0000733) | 2.73827301 |
| 82 | lung cell differentiation (GO:0060479) | 2.72735037 |
| 83 | long term synaptic depression (GO:0060292) | 2.72149797 |
| 84 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.69385108 |
| 85 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.68705855 |
| 86 | detection of chemical stimulus involved in sensory perception (GO:0050907) | 2.67720215 |
| 87 | viral entry into host cell (GO:0046718) | 2.66644770 |
| 88 | positive regulation of interleukin-17 production (GO:0032740) | 2.65642135 |
| 89 | negative regulation of cyclic nucleotide biosynthetic process (GO:0030803) | 2.65426918 |
| 90 | negative regulation of smooth muscle contraction (GO:0045986) | 2.64081574 |
| 91 | regulation of DNA-templated transcription, initiation (GO:2000142) | 2.62379794 |
| 92 | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc | 2.61533884 |
| 93 | positive regulation of cGMP biosynthetic process (GO:0030828) | 2.56187994 |
| 94 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.56072654 |
| 95 | regulation of cell migration involved in sprouting angiogenesis (GO:0090049) | 2.55602839 |
| 96 | neuronal action potential (GO:0019228) | 2.49936678 |
| 97 | positive regulation of cardiac muscle cell differentiation (GO:2000727) | 2.49299074 |
| 98 | regulation of female receptivity (GO:0045924) | 12.6459261 |
| 99 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 11.7657260 |
| 100 | female mating behavior (GO:0060180) | 11.0654830 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 4.36020964 |
| 2 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 4.09151534 |
| 3 | VDR_22108803_ChIP-Seq_LS180_Human | 3.22451863 |
| 4 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.11858114 |
| 5 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.00401647 |
| 6 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 2.89005074 |
| 7 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.89005074 |
| 8 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.78136271 |
| 9 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.53506638 |
| 10 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.42160547 |
| 11 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.28766187 |
| 12 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.25747221 |
| 13 | RXR_22108803_ChIP-Seq_LS180_Human | 2.14731914 |
| 14 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.05567861 |
| 15 | SOX2_19829295_ChIP-Seq_ESCs_Human | 2.02621375 |
| 16 | NANOG_19829295_ChIP-Seq_ESCs_Human | 2.02621375 |
| 17 | FUS_26573619_Chip-Seq_HEK293_Human | 1.99363421 |
| 18 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.91634300 |
| 19 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.83857216 |
| 20 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.82996779 |
| 21 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.77625019 |
| 22 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.76080159 |
| 23 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.74884703 |
| 24 | TCF4_23295773_ChIP-Seq_U87_Human | 1.72392621 |
| 25 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.71499779 |
| 26 | P300_19829295_ChIP-Seq_ESCs_Human | 1.68471873 |
| 27 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.65141040 |
| 28 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.64868572 |
| 29 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.64634585 |
| 30 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.61914267 |
| 31 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.60144381 |
| 32 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.57228585 |
| 33 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.56151084 |
| 34 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.56151084 |
| 35 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.53087909 |
| 36 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.53050621 |
| 37 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.47740724 |
| 38 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.47271268 |
| 39 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.44959929 |
| 40 | STAT3_23295773_ChIP-Seq_U87_Human | 1.42556571 |
| 41 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.41944078 |
| 42 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.41414137 |
| 43 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.39175227 |
| 44 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.34571062 |
| 45 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.33899413 |
| 46 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.31185817 |
| 47 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.30473264 |
| 48 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.29504010 |
| 49 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.28999905 |
| 50 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.26536389 |
| 51 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.26167954 |
| 52 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.25934634 |
| 53 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.25181694 |
| 54 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.24762786 |
| 55 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.22567432 |
| 56 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.22418688 |
| 57 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.20871553 |
| 58 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.20756533 |
| 59 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.20711794 |
| 60 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.20310536 |
| 61 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.20266462 |
| 62 | EWS_26573619_Chip-Seq_HEK293_Human | 1.20112913 |
| 63 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.19374653 |
| 64 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 1.18996608 |
| 65 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.17733822 |
| 66 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.15101096 |
| 67 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.13368566 |
| 68 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.13172346 |
| 69 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.12936116 |
| 70 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.11326348 |
| 71 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 1.10783519 |
| 72 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.10659515 |
| 73 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.10594285 |
| 74 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.10163733 |
| 75 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.09943208 |
| 76 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.09706423 |
| 77 | CEBPB_22108803_ChIP-Seq_LS180_Human | 1.08207844 |
| 78 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.08075738 |
| 79 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.07981026 |
| 80 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.07980723 |
| 81 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.07970853 |
| 82 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.07336133 |
| 83 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.07081345 |
| 84 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.06210938 |
| 85 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.05780511 |
| 86 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.04828968 |
| 87 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.04369530 |
| 88 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.03852413 |
| 89 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.03373324 |
| 90 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.03116289 |
| 91 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.02927250 |
| 92 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.02852807 |
| 93 | AR_20517297_ChIP-Seq_VCAP_Human | 1.00199626 |
| 94 | GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.99379137 |
| 95 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.99377876 |
| 96 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.98245592 |
| 97 | SOX9_26525672_Chip-Seq_Limbbuds_Mouse | 0.96222515 |
| 98 | CBP_21632823_ChIP-Seq_H3396_Human | 0.95730488 |
| 99 | KDM2B_26808549_Chip-Seq_REH_Human | 0.95680849 |
| 100 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.95672198 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009780_abnormal_chondrocyte_physiolo | 9.15813996 |
| 2 | MP0003136_yellow_coat_color | 5.41694476 |
| 3 | MP0002876_abnormal_thyroid_physiology | 5.16544774 |
| 4 | MP0009278_abnormal_bone_marrow | 4.54968445 |
| 5 | MP0002163_abnormal_gland_morphology | 4.24553335 |
| 6 | MP0005360_urolithiasis | 3.32625187 |
| 7 | MP0001968_abnormal_touch/_nociception | 3.02746366 |
| 8 | MP0000372_irregular_coat_pigmentation | 2.92236530 |
| 9 | MP0003879_abnormal_hair_cell | 2.88535259 |
| 10 | MP0005379_endocrine/exocrine_gland_phen | 2.67405150 |
| 11 | MP0000681_abnormal_thyroid_gland | 2.66476717 |
| 12 | MP0005503_abnormal_tendon_morphology | 2.51586965 |
| 13 | MP0002132_abnormal_respiratory_system | 2.23103713 |
| 14 | MP0006054_spinal_hemorrhage | 2.01855423 |
| 15 | MP0001348_abnormal_lacrimal_gland | 1.96944032 |
| 16 | MP0005551_abnormal_eye_electrophysiolog | 1.87975861 |
| 17 | MP0006035_abnormal_mitochondrial_morpho | 1.77277546 |
| 18 | MP0001501_abnormal_sleep_pattern | 1.76836366 |
| 19 | MP0003880_abnormal_central_pattern | 1.73695500 |
| 20 | MP0008775_abnormal_heart_ventricle | 1.69419875 |
| 21 | MP0001346_abnormal_lacrimal_gland | 1.67949149 |
| 22 | MP0000678_abnormal_parathyroid_gland | 1.62656318 |
| 23 | MP0005397_hematopoietic_system_phenotyp | 1.60172275 |
| 24 | MP0001545_abnormal_hematopoietic_system | 1.60172275 |
| 25 | MP0003045_fibrosis | 1.57229019 |
| 26 | MP0005646_abnormal_pituitary_gland | 1.53915616 |
| 27 | MP0006276_abnormal_autonomic_nervous | 1.53375553 |
| 28 | MP0003638_abnormal_response/metabolism_ | 1.53370392 |
| 29 | MP0004885_abnormal_endolymph | 1.51118683 |
| 30 | MP0003941_abnormal_skin_development | 1.48934498 |
| 31 | MP0009764_decreased_sensitivity_to | 1.42347476 |
| 32 | MP0004381_abnormal_hair_follicle | 1.41345185 |
| 33 | MP0001664_abnormal_digestion | 1.39374275 |
| 34 | MP0004130_abnormal_muscle_cell | 1.38618582 |
| 35 | MP0008057_abnormal_DNA_replication | 1.37224595 |
| 36 | MP0004782_abnormal_surfactant_physiolog | 1.31698140 |
| 37 | MP0009333_abnormal_splenocyte_physiolog | 1.27924194 |
| 38 | MP0002249_abnormal_larynx_morphology | 1.27469394 |
| 39 | MP0003938_abnormal_ear_development | 1.24635102 |
| 40 | MP0000049_abnormal_middle_ear | 1.14128819 |
| 41 | MP0005187_abnormal_penis_morphology | 1.13621569 |
| 42 | MP0005310_abnormal_salivary_gland | 1.13421434 |
| 43 | MP0009765_abnormal_xenobiotic_induced | 1.13366345 |
| 44 | MP0000230_abnormal_systemic_arterial | 1.11204560 |
| 45 | MP0003633_abnormal_nervous_system | 1.06053685 |
| 46 | MP0006072_abnormal_retinal_apoptosis | 1.03619228 |
| 47 | MP0003567_abnormal_fetal_cardiomyocyte | 1.03486509 |
| 48 | MP0003646_muscle_fatigue | 1.03359495 |
| 49 | MP0000569_abnormal_digit_pigmentation | 0.96569152 |
| 50 | MP0008875_abnormal_xenobiotic_pharmacok | 0.93373750 |
| 51 | MP0001485_abnormal_pinna_reflex | 0.91335018 |
| 52 | MP0005645_abnormal_hypothalamus_physiol | 0.91240167 |
| 53 | MP0008877_abnormal_DNA_methylation | 0.90949739 |
| 54 | MP0008872_abnormal_physiological_respon | 0.89074403 |
| 55 | MP0002909_abnormal_adrenal_gland | 0.88154412 |
| 56 | MP0009745_abnormal_behavioral_response | 0.87419786 |
| 57 | MP0000685_abnormal_immune_system | 0.86455225 |
| 58 | MP0001486_abnormal_startle_reflex | 0.85212356 |
| 59 | MP0001270_distended_abdomen | 0.84442217 |
| 60 | MP0009046_muscle_twitch | 0.84029810 |
| 61 | MP0002733_abnormal_thermal_nociception | 0.81969974 |
| 62 | MP0005670_abnormal_white_adipose | 0.79196275 |
| 63 | MP0000383_abnormal_hair_follicle | 0.79167953 |
| 64 | MP0003195_calcinosis | 0.77123557 |
| 65 | MP0001963_abnormal_hearing_physiology | 0.75743002 |
| 66 | MP0002272_abnormal_nervous_system | 0.73314358 |
| 67 | MP0002168_other_aberrant_phenotype | 0.70493386 |
| 68 | MP0002148_abnormal_hypersensitivity_rea | 0.70131792 |
| 69 | MP0004147_increased_porphyrin_level | 0.68845647 |
| 70 | MP0002693_abnormal_pancreas_physiology | 0.67974362 |
| 71 | MP0003718_maternal_effect | 0.65514470 |
| 72 | MP0004085_abnormal_heartbeat | 0.65138023 |
| 73 | MP0001851_eye_inflammation | 0.63440680 |
| 74 | MP0005410_abnormal_fertilization | 0.62752272 |
| 75 | MP0005253_abnormal_eye_physiology | 0.61903146 |
| 76 | MP0000647_abnormal_sebaceous_gland | 0.61386424 |
| 77 | MP0003959_abnormal_lean_body | 0.61229981 |
| 78 | MP0003183_abnormal_peptide_metabolism | 0.60724693 |
| 79 | MP0010678_abnormal_skin_adnexa | 0.59563200 |
| 80 | MP0009672_abnormal_birth_weight | 0.59323455 |
| 81 | MP0003631_nervous_system_phenotype | 0.59223599 |
| 82 | MP0003937_abnormal_limbs/digits/tail_de | 0.58471007 |
| 83 | MP0001970_abnormal_pain_threshold | 0.57333938 |
| 84 | MP0001881_abnormal_mammary_gland | 0.57194109 |
| 85 | MP0005395_other_phenotype | 0.55828985 |
| 86 | MP0001756_abnormal_urination | 0.54951299 |
| 87 | MP0002736_abnormal_nociception_after | 0.52997416 |
| 88 | MP0002971_abnormal_brown_adipose | 0.51651727 |
| 89 | MP0006036_abnormal_mitochondrial_physio | 0.49535251 |
| 90 | MP0002557_abnormal_social/conspecific_i | 0.46579139 |
| 91 | MP0010030_abnormal_orbit_morphology | 0.46468208 |
| 92 | MP0004742_abnormal_vestibular_system | 0.45927483 |
| 93 | MP0005334_abnormal_fat_pad | 0.45551635 |
| 94 | MP0009384_cardiac_valve_regurgitation | 0.45012950 |
| 95 | MP0002572_abnormal_emotion/affect_behav | 0.43532014 |
| 96 | MP0005167_abnormal_blood-brain_barrier | 0.43438239 |
| 97 | MP0002998_abnormal_bone_remodeling | 0.43018540 |
| 98 | MP0002653_abnormal_ependyma_morphology | 0.42949560 |
| 99 | MP0002229_neurodegeneration | 0.41790338 |
| 100 | MP0005195_abnormal_posterior_eye | 0.41516863 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Volvulus (HP:0002580) | 5.79653828 |
| 2 | Intestinal atresia (HP:0011100) | 5.55977616 |
| 3 | Pancreatic islet-cell hyperplasia (HP:0004510) | 5.23780420 |
| 4 | Mesangial abnormality (HP:0001966) | 5.04268852 |
| 5 | Abnormality of the aortic arch (HP:0012303) | 4.63891476 |
| 6 | Oligodontia (HP:0000677) | 4.60771577 |
| 7 | Broad alveolar ridges (HP:0000187) | 4.57147444 |
| 8 | Large for gestational age (HP:0001520) | 4.41520431 |
| 9 | Type II lissencephaly (HP:0007260) | 4.36408910 |
| 10 | Severe visual impairment (HP:0001141) | 4.13629380 |
| 11 | Thickened helices (HP:0000391) | 4.03749969 |
| 12 | Concave nail (HP:0001598) | 3.84615820 |
| 13 | Tubular atrophy (HP:0000092) | 3.71346830 |
| 14 | Congenital stationary night blindness (HP:0007642) | 3.69186179 |
| 15 | Gaze-evoked nystagmus (HP:0000640) | 3.68362875 |
| 16 | Abnormality of the ileum (HP:0001549) | 3.64869250 |
| 17 | Hypoproteinemia (HP:0003075) | 3.63034880 |
| 18 | Abnormality of endocrine pancreas physiology (HP:0012093) | 3.55117179 |
| 19 | Abnormality of the pancreatic islet cells (HP:0006476) | 3.55117179 |
| 20 | Congenital ichthyosiform erythroderma (HP:0007431) | 3.44453927 |
| 21 | Cerebellar dysplasia (HP:0007033) | 3.38641353 |
| 22 | Neonatal respiratory distress (HP:0002643) | 3.15974112 |
| 23 | Autoimmune hemolytic anemia (HP:0001890) | 3.13960233 |
| 24 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.13103812 |
| 25 | Gastrointestinal atresia (HP:0002589) | 3.08469150 |
| 26 | Keratoconjunctivitis sicca (HP:0001097) | 2.93246435 |
| 27 | Conical tooth (HP:0000698) | 2.92785205 |
| 28 | Keratoconjunctivitis (HP:0001096) | 2.89217370 |
| 29 | Premature skin wrinkling (HP:0100678) | 2.88244086 |
| 30 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.83676550 |
| 31 | Focal motor seizures (HP:0011153) | 2.76284886 |
| 32 | Increased connective tissue (HP:0009025) | 2.73898397 |
| 33 | Poor head control (HP:0002421) | 2.71666986 |
| 34 | Embryonal renal neoplasm (HP:0011794) | 2.71652994 |
| 35 | Optic nerve hypoplasia (HP:0000609) | 2.70927157 |
| 36 | Attenuation of retinal blood vessels (HP:0007843) | 2.69211084 |
| 37 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.69176736 |
| 38 | Abnormality of macular pigmentation (HP:0008002) | 2.68479226 |
| 39 | Lissencephaly (HP:0001339) | 2.66896792 |
| 40 | Agitation (HP:0000713) | 2.60253329 |
| 41 | Focal seizures (HP:0007359) | 2.53434683 |
| 42 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.42464229 |
| 43 | Hyperthyroidism (HP:0000836) | 2.40714902 |
| 44 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.40619766 |
| 45 | Hypoplasia of the fovea (HP:0007750) | 2.40619766 |
| 46 | Poor speech (HP:0002465) | 2.39554214 |
| 47 | Chromsome breakage (HP:0040012) | 2.38827301 |
| 48 | True hermaphroditism (HP:0010459) | 2.38294096 |
| 49 | Abnormality of the vitreous humor (HP:0004327) | 2.34198237 |
| 50 | Soft skin (HP:0000977) | 2.32286522 |
| 51 | Short chin (HP:0000331) | 2.30026497 |
| 52 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.29883220 |
| 53 | 11 pairs of ribs (HP:0000878) | 2.25732318 |
| 54 | Pigmentary retinal degeneration (HP:0001146) | 2.25577086 |
| 55 | Central scotoma (HP:0000603) | 2.24871486 |
| 56 | Autoimmune thrombocytopenia (HP:0001973) | 2.21761314 |
| 57 | Large eyes (HP:0001090) | 2.21032682 |
| 58 | Absent eyebrow (HP:0002223) | 2.18642026 |
| 59 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.17869425 |
| 60 | Hypoplasia of the brainstem (HP:0002365) | 2.17869425 |
| 61 | Myositis (HP:0100614) | 2.17135883 |
| 62 | Muscular dystrophy (HP:0003560) | 2.14560772 |
| 63 | Hemiparesis (HP:0001269) | 2.14265021 |
| 64 | Goiter (HP:0000853) | 2.13100116 |
| 65 | Anhidrosis (HP:0000970) | 2.13090404 |
| 66 | Bile duct proliferation (HP:0001408) | 2.11785142 |
| 67 | Abnormal biliary tract physiology (HP:0012439) | 2.11785142 |
| 68 | Orchitis (HP:0100796) | 2.09105063 |
| 69 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.08328010 |
| 70 | Progressive inability to walk (HP:0002505) | 2.04575725 |
| 71 | Decreased central vision (HP:0007663) | 2.04259750 |
| 72 | Abnormality of the alveolar ridges (HP:0006477) | 2.03236454 |
| 73 | Broad-based gait (HP:0002136) | 2.01497873 |
| 74 | Tented upper lip vermilion (HP:0010804) | 2.01115523 |
| 75 | Keratitis (HP:0000491) | 2.00728877 |
| 76 | Thyroid-stimulating hormone excess (HP:0002925) | 10.0480555 |
| 77 | Non-midline cleft lip (HP:0100335) | 1.96218251 |
| 78 | Scotoma (HP:0000575) | 1.95527724 |
| 79 | Type I diabetes mellitus (HP:0100651) | 1.95193067 |
| 80 | Hypoplasia of the pons (HP:0012110) | 1.91942861 |
| 81 | Retinal dysplasia (HP:0007973) | 1.91428938 |
| 82 | Cone-rod dystrophy (HP:0000548) | 1.90075954 |
| 83 | 3-Methylglutaconic aciduria (HP:0003535) | 1.88464236 |
| 84 | Gastrointestinal dysmotility (HP:0002579) | 1.88281634 |
| 85 | Aplasia/Hypoplasia affecting the fundus (HP:0008057) | 1.86834995 |
| 86 | Nonprogressive disorder (HP:0003680) | 1.86789960 |
| 87 | Abnormality of the fovea (HP:0000493) | 1.83850949 |
| 88 | Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318) | 1.82784925 |
| 89 | Severe Myopia (HP:0011003) | 1.82701800 |
| 90 | Hypoplastic nipples (HP:0002557) | 1.82200722 |
| 91 | Long nose (HP:0003189) | 1.80831204 |
| 92 | Increased IgM level (HP:0003496) | 1.77666226 |
| 93 | Abnormal pupillary function (HP:0007686) | 1.77219337 |
| 94 | Pancreatic cysts (HP:0001737) | 1.77065192 |
| 95 | Hyperpituitarism (HP:0010514) | 1.76395654 |
| 96 | Impulsivity (HP:0100710) | 1.75680222 |
| 97 | Pendular nystagmus (HP:0012043) | 1.73015770 |
| 98 | Brittle hair (HP:0002299) | 1.71671771 |
| 99 | Hypoplastic iliac wings (HP:0002866) | 1.70253650 |
| 100 | Hydroxyprolinuria (HP:0003080) | 1.70099677 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ADRBK2 | 8.83940433 |
| 2 | FRK | 6.04358656 |
| 3 | BUB1 | 3.34420383 |
| 4 | PINK1 | 3.31646090 |
| 5 | IRAK3 | 3.09820852 |
| 6 | PNCK | 3.09564026 |
| 7 | TRIM28 | 3.08017199 |
| 8 | BCR | 2.85876006 |
| 9 | ERN1 | 2.76525911 |
| 10 | MAP3K10 | 2.25121583 |
| 11 | ADRBK1 | 2.10448553 |
| 12 | WEE1 | 1.83550196 |
| 13 | CDK12 | 1.74251199 |
| 14 | TAF1 | 1.69435885 |
| 15 | PRKCG | 1.57210405 |
| 16 | MST4 | 1.40100229 |
| 17 | PLK2 | 1.37462619 |
| 18 | GRK1 | 1.37431551 |
| 19 | ERBB2 | 1.35843179 |
| 20 | KIT | 1.28903981 |
| 21 | STK3 | 1.27949081 |
| 22 | PRKCE | 1.22129602 |
| 23 | VRK2 | 1.14625703 |
| 24 | CLK1 | 1.13947674 |
| 25 | ACVR1B | 1.11203251 |
| 26 | IRAK1 | 0.93143269 |
| 27 | DYRK3 | 0.90769328 |
| 28 | NEK1 | 0.90505650 |
| 29 | CDK19 | 0.88735339 |
| 30 | MKNK2 | 0.87249920 |
| 31 | EIF2AK2 | 0.85765412 |
| 32 | TYRO3 | 0.82348784 |
| 33 | BMPR1B | 0.81853371 |
| 34 | TGFBR1 | 0.77961817 |
| 35 | OXSR1 | 0.73839605 |
| 36 | CAMK2A | 0.69560746 |
| 37 | PLK4 | 0.69435134 |
| 38 | CAMK1G | 0.68696377 |
| 39 | TEC | 0.66797945 |
| 40 | MAPK11 | 0.66551827 |
| 41 | MKNK1 | 0.63616263 |
| 42 | AURKB | 0.60914853 |
| 43 | NUAK1 | 0.59674001 |
| 44 | DYRK1A | 0.59548315 |
| 45 | NEK2 | 0.58719172 |
| 46 | WNK3 | 0.54599343 |
| 47 | BRSK1 | 0.53990959 |
| 48 | PRKCI | 0.51515975 |
| 49 | CSNK1A1 | 0.50989069 |
| 50 | MET | 0.50698590 |
| 51 | DAPK2 | 0.49699458 |
| 52 | NEK9 | 0.48910951 |
| 53 | PRKCB | 0.46605654 |
| 54 | MAP2K7 | 0.45195844 |
| 55 | RIPK1 | 0.43971425 |
| 56 | EPHA2 | 0.42933624 |
| 57 | CSNK2A2 | 0.41887571 |
| 58 | MAPKAPK5 | 0.41270111 |
| 59 | FGFR1 | 0.40761190 |
| 60 | INSRR | 0.39316576 |
| 61 | TXK | 0.39196391 |
| 62 | STK38 | 0.38991597 |
| 63 | ATM | 0.38764387 |
| 64 | GRK5 | 0.35858590 |
| 65 | PLK1 | 0.34943088 |
| 66 | CSNK2A1 | 0.33583223 |
| 67 | DYRK2 | 0.33511906 |
| 68 | STK10 | 0.33145633 |
| 69 | PTK2B | 0.32720498 |
| 70 | MAPK1 | 0.32425169 |
| 71 | STK39 | 0.31425132 |
| 72 | AKT1 | 0.31115407 |
| 73 | CAMK1 | 0.30984768 |
| 74 | MAP4K2 | 0.30046283 |
| 75 | CDK15 | 0.29796828 |
| 76 | CSNK1G3 | 0.29794826 |
| 77 | CDK11A | 0.29595152 |
| 78 | ATR | 0.29315525 |
| 79 | PAK3 | 0.28567973 |
| 80 | CDK18 | 0.27613190 |
| 81 | ROCK1 | 0.27081612 |
| 82 | CAMK2D | 0.26993099 |
| 83 | ABL1 | 0.26709798 |
| 84 | AKT2 | 0.26463726 |
| 85 | RPS6KA3 | 0.26134259 |
| 86 | CSNK1E | 0.26083982 |
| 87 | PRKCA | 0.26081131 |
| 88 | MELK | 0.26077785 |
| 89 | CSNK1A1L | 0.25958384 |
| 90 | PRKACG | 0.25229717 |
| 91 | TRPM7 | 0.24832489 |
| 92 | CDK5 | 0.24571511 |
| 93 | GSK3B | 0.24462076 |
| 94 | CDK2 | 0.24055228 |
| 95 | NTRK2 | 0.23891220 |
| 96 | CHUK | 0.23761663 |
| 97 | SGK1 | 0.23451198 |
| 98 | PRKDC | 0.22805501 |
| 99 | CDK1 | 0.22651087 |
| 100 | MAPK8 | 0.21871990 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Tryptophan metabolism_Homo sapiens_hsa00380 | 3.32684904 |
| 2 | Olfactory transduction_Homo sapiens_hsa04740 | 3.13730544 |
| 3 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 3.07857960 |
| 4 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 2.61414082 |
| 5 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 2.59953771 |
| 6 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 2.59093584 |
| 7 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 2.45743800 |
| 8 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.38620243 |
| 9 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 2.36674188 |
| 10 | Phototransduction_Homo sapiens_hsa04744 | 2.32251727 |
| 11 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.28146550 |
| 12 | Morphine addiction_Homo sapiens_hsa05032 | 2.17115605 |
| 13 | Basal transcription factors_Homo sapiens_hsa03022 | 1.96452912 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 1.92988368 |
| 15 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.90770025 |
| 16 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.87257042 |
| 17 | Nicotine addiction_Homo sapiens_hsa05033 | 1.81140571 |
| 18 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.75997750 |
| 19 | Salivary secretion_Homo sapiens_hsa04970 | 1.72873266 |
| 20 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.71549295 |
| 21 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.64624297 |
| 22 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.63692616 |
| 23 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.50469060 |
| 24 | ABC transporters_Homo sapiens_hsa02010 | 1.39125318 |
| 25 | Circadian entrainment_Homo sapiens_hsa04713 | 1.38826928 |
| 26 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.38272738 |
| 27 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.32328020 |
| 28 | Taste transduction_Homo sapiens_hsa04742 | 1.24303833 |
| 29 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.23024004 |
| 30 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.21400741 |
| 31 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.21111075 |
| 32 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.18181384 |
| 33 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.18133273 |
| 34 | Sulfur relay system_Homo sapiens_hsa04122 | 1.16448388 |
| 35 | Retinol metabolism_Homo sapiens_hsa00830 | 1.16189546 |
| 36 | Allograft rejection_Homo sapiens_hsa05330 | 1.15350007 |
| 37 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.15091950 |
| 38 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.14058087 |
| 39 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.11796861 |
| 40 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.11401319 |
| 41 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.06990654 |
| 42 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.04976931 |
| 43 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.04478191 |
| 44 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.03517468 |
| 45 | Mineral absorption_Homo sapiens_hsa04978 | 1.00321699 |
| 46 | Renin secretion_Homo sapiens_hsa04924 | 0.99271773 |
| 47 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.98791730 |
| 48 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.94948188 |
| 49 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.93772420 |
| 50 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.93008447 |
| 51 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.89370749 |
| 52 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.89275863 |
| 53 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.87286031 |
| 54 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.86345227 |
| 55 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.83654086 |
| 56 | GABAergic synapse_Homo sapiens_hsa04727 | 0.83376348 |
| 57 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.81379363 |
| 58 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.80573683 |
| 59 | Asthma_Homo sapiens_hsa05310 | 0.80527651 |
| 60 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.78615905 |
| 61 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.77805439 |
| 62 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.77449813 |
| 63 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.76738317 |
| 64 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.75513346 |
| 65 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.74159087 |
| 66 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.73895106 |
| 67 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.73149924 |
| 68 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.73117652 |
| 69 | Purine metabolism_Homo sapiens_hsa00230 | 0.71209723 |
| 70 | Histidine metabolism_Homo sapiens_hsa00340 | 0.65127872 |
| 71 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.63641595 |
| 72 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.63541139 |
| 73 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.63242633 |
| 74 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.62867367 |
| 75 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.62769569 |
| 76 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.60125937 |
| 77 | Long-term depression_Homo sapiens_hsa04730 | 0.59057165 |
| 78 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.58170293 |
| 79 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.56343449 |
| 80 | Metabolic pathways_Homo sapiens_hsa01100 | 0.55081457 |
| 81 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.54002557 |
| 82 | RNA polymerase_Homo sapiens_hsa03020 | 0.53979722 |
| 83 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.52442491 |
| 84 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.50037788 |
| 85 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.49423837 |
| 86 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.49363913 |
| 87 | RNA degradation_Homo sapiens_hsa03018 | 0.46508974 |
| 88 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.46445955 |
| 89 | Lysine degradation_Homo sapiens_hsa00310 | 0.44358437 |
| 90 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.41687327 |
| 91 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.40482449 |
| 92 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.39181246 |
| 93 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.36153205 |
| 94 | Legionellosis_Homo sapiens_hsa05134 | 0.36130109 |
| 95 | Insulin secretion_Homo sapiens_hsa04911 | 0.35003054 |
| 96 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.34785657 |
| 97 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.34212283 |
| 98 | DNA replication_Homo sapiens_hsa03030 | 0.31161867 |
| 99 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.30266704 |
| 100 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.28184375 |

