AMD1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)9.66260278
2negative regulation of cAMP-mediated signaling (GO:0043951)8.79239796
3opioid receptor signaling pathway (GO:0038003)8.60918482
4behavioral response to ethanol (GO:0048149)7.56260024
5regulation of protein glycosylation (GO:0060049)6.60605047
6adult feeding behavior (GO:0008343)6.51494157
7regulation of translational termination (GO:0006449)6.46571731
8negative regulation of calcium ion-dependent exocytosis (GO:0045955)6.39371337
9ether lipid metabolic process (GO:0046485)6.37809766
10regulation of acrosome reaction (GO:0060046)6.18025753
11relaxation of smooth muscle (GO:0044557)5.83982221
12protein-chromophore linkage (GO:0018298)5.62004714
13positive regulation of cAMP-mediated signaling (GO:0043950)5.39924110
14notochord development (GO:0030903)5.08010196
15multicellular organismal reproductive behavior (GO:0033057)5.07044072
16negative regulation of T cell receptor signaling pathway (GO:0050860)5.05298393
17negative regulation of nitric oxide biosynthetic process (GO:0045019)4.98970642
18piRNA metabolic process (GO:0034587)4.80854653
19DNA replication-dependent nucleosome organization (GO:0034723)4.79848114
20DNA replication-dependent nucleosome assembly (GO:0006335)4.79848114
21glomerular visceral epithelial cell development (GO:0072015)4.70838805
22negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.40628583
23transmission of nerve impulse (GO:0019226)4.28211465
24sphingosine metabolic process (GO:0006670)4.15386975
25N-terminal protein amino acid acetylation (GO:0006474)4.14260026
26glomerular epithelial cell development (GO:0072310)4.09909453
27meiotic chromosome segregation (GO:0045132)4.08526365
28thrombin receptor signaling pathway (GO:0070493)4.07523233
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.05481734
30ncRNA catabolic process (GO:0034661)4.02350871
31negative regulation of adenylate cyclase activity (GO:0007194)4.01391471
32proline biosynthetic process (GO:0006561)3.96831164
33cellular response to ammonium ion (GO:0071242)3.84272851
34negative regulation of myotube differentiation (GO:0010832)3.84008720
35negative regulation of cyclase activity (GO:0031280)3.80914525
36regulation of glutamate receptor signaling pathway (GO:1900449)3.72615786
37diol metabolic process (GO:0034311)3.67915594
38regulation of rhodopsin mediated signaling pathway (GO:0022400)3.67189102
39negative regulation of lyase activity (GO:0051350)3.63853655
40sphingoid metabolic process (GO:0046519)3.62336272
41glomerular basement membrane development (GO:0032836)3.56699179
42positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.49669117
43regulation of memory T cell differentiation (GO:0043380)3.45985199
44glycerol ether metabolic process (GO:0006662)3.42268098
45nephron tubule formation (GO:0072079)3.42047878
46mRNA cleavage (GO:0006379)3.40966546
47indolalkylamine metabolic process (GO:0006586)3.32811560
48phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.30988179
49rhodopsin mediated signaling pathway (GO:0016056)3.29353640
50detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.28351116
51multi-organism reproductive behavior (GO:0044705)3.23653033
52coenzyme catabolic process (GO:0009109)3.20518608
53reproductive behavior (GO:0019098)3.18701919
54cellular response to alkaloid (GO:0071312)3.18134893
55ether metabolic process (GO:0018904)3.14403620
56regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.13101984
57drug catabolic process (GO:0042737)3.12657185
58regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.11152225
59regulation of cAMP-mediated signaling (GO:0043949)3.11127513
60regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)3.09794012
61microtubule severing (GO:0051013)3.09646522
62negative regulation of glycoprotein biosynthetic process (GO:0010561)3.07175009
63dopamine receptor signaling pathway (GO:0007212)3.02042358
64proline metabolic process (GO:0006560)2.98586486
65cornea development in camera-type eye (GO:0061303)2.96621265
66regulation of T cell receptor signaling pathway (GO:0050856)2.90887856
67lung epithelial cell differentiation (GO:0060487)2.88411177
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86340558
69cell-cell junction maintenance (GO:0045217)2.86229992
70attachment of spindle microtubules to kinetochore (GO:0008608)2.85221260
71urate metabolic process (GO:0046415)2.82055439
72dopamine transport (GO:0015872)2.81196964
73UMP biosynthetic process (GO:0006222)2.80694173
74pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.80694173
75UMP metabolic process (GO:0046049)2.80694173
76pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.80694173
77negative regulation of cAMP biosynthetic process (GO:0030818)2.76894084
78tachykinin receptor signaling pathway (GO:0007217)2.75715797
79vitamin catabolic process (GO:0009111)2.74192656
80fat-soluble vitamin catabolic process (GO:0042363)2.74192656
81DNA strand renaturation (GO:0000733)2.73827301
82lung cell differentiation (GO:0060479)2.72735037
83long term synaptic depression (GO:0060292)2.72149797
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69385108
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68705855
86detection of chemical stimulus involved in sensory perception (GO:0050907)2.67720215
87viral entry into host cell (GO:0046718)2.66644770
88positive regulation of interleukin-17 production (GO:0032740)2.65642135
89negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.65426918
90negative regulation of smooth muscle contraction (GO:0045986)2.64081574
91regulation of DNA-templated transcription, initiation (GO:2000142)2.62379794
92positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.61533884
93positive regulation of cGMP biosynthetic process (GO:0030828)2.56187994
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.56072654
95regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.55602839
96neuronal action potential (GO:0019228)2.49936678
97positive regulation of cardiac muscle cell differentiation (GO:2000727)2.49299074
98regulation of female receptivity (GO:0045924)12.6459261
99negative regulation of cytosolic calcium ion concentration (GO:0051481)11.7657260
100female mating behavior (GO:0060180)11.0654830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.36020964
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.09151534
3VDR_22108803_ChIP-Seq_LS180_Human3.22451863
4EZH2_22144423_ChIP-Seq_EOC_Human3.11858114
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00401647
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.89005074
7TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.89005074
8GBX2_23144817_ChIP-Seq_PC3_Human2.78136271
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53506638
10TAF15_26573619_Chip-Seq_HEK293_Human2.42160547
11ZNF274_21170338_ChIP-Seq_K562_Hela2.28766187
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25747221
13RXR_22108803_ChIP-Seq_LS180_Human2.14731914
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05567861
15SOX2_19829295_ChIP-Seq_ESCs_Human2.02621375
16NANOG_19829295_ChIP-Seq_ESCs_Human2.02621375
17FUS_26573619_Chip-Seq_HEK293_Human1.99363421
18EGR1_23403033_ChIP-Seq_LIVER_Mouse1.91634300
19TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.83857216
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.82996779
21BCAT_22108803_ChIP-Seq_LS180_Human1.77625019
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76080159
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74884703
24TCF4_23295773_ChIP-Seq_U87_Human1.72392621
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71499779
26P300_19829295_ChIP-Seq_ESCs_Human1.68471873
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65141040
28E2F7_22180533_ChIP-Seq_HELA_Human1.64868572
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64634585
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61914267
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.60144381
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.57228585
33CBP_20019798_ChIP-Seq_JUKART_Human1.56151084
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56151084
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53087909
36PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.53050621
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47740724
38DROSHA_22980978_ChIP-Seq_HELA_Human1.47271268
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44959929
40STAT3_23295773_ChIP-Seq_U87_Human1.42556571
41CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41944078
42EGR1_19032775_ChIP-ChIP_M12_Human1.41414137
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39175227
44TP53_22573176_ChIP-Seq_HFKS_Human1.34571062
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33899413
46IGF1R_20145208_ChIP-Seq_DFB_Human1.31185817
47LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30473264
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.29504010
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28999905
50ER_23166858_ChIP-Seq_MCF-7_Human1.26536389
51TCF4_22108803_ChIP-Seq_LS180_Human1.26167954
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25934634
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.25181694
54FLI1_21867929_ChIP-Seq_TH2_Mouse1.24762786
55PRDM14_20953172_ChIP-Seq_ESCs_Human1.22567432
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.22418688
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20871553
58HTT_18923047_ChIP-ChIP_STHdh_Human1.20756533
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.20711794
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20310536
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.20266462
62EWS_26573619_Chip-Seq_HEK293_Human1.20112913
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19374653
64GATA3_21867929_ChIP-Seq_TH1_Mouse1.18996608
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17733822
66TP53_18474530_ChIP-ChIP_U2OS_Human1.15101096
67SMAD4_21799915_ChIP-Seq_A2780_Human1.13368566
68CDX2_22108803_ChIP-Seq_LS180_Human1.13172346
69TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12936116
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11326348
71FOXH1_21741376_ChIP-Seq_ESCs_Human1.10783519
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10659515
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10594285
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10163733
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09943208
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09706423
77CEBPB_22108803_ChIP-Seq_LS180_Human1.08207844
78TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.08075738
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.07981026
80NANOG_20526341_ChIP-Seq_ESCs_Human1.07980723
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07970853
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07336133
83HOXB7_26014856_ChIP-Seq_BT474_Human1.07081345
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06210938
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05780511
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04828968
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04369530
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.03852413
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03373324
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03116289
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02927250
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.02852807
93AR_20517297_ChIP-Seq_VCAP_Human1.00199626
94GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.99379137
95AR_21909140_ChIP-Seq_LNCAP_Human0.99377876
96SOX2_21211035_ChIP-Seq_LN229_Gbm0.98245592
97SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96222515
98CBP_21632823_ChIP-Seq_H3396_Human0.95730488
99KDM2B_26808549_Chip-Seq_REH_Human0.95680849
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95672198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo9.15813996
2MP0003136_yellow_coat_color5.41694476
3MP0002876_abnormal_thyroid_physiology5.16544774
4MP0009278_abnormal_bone_marrow4.54968445
5MP0002163_abnormal_gland_morphology4.24553335
6MP0005360_urolithiasis3.32625187
7MP0001968_abnormal_touch/_nociception3.02746366
8MP0000372_irregular_coat_pigmentation2.92236530
9MP0003879_abnormal_hair_cell2.88535259
10MP0005379_endocrine/exocrine_gland_phen2.67405150
11MP0000681_abnormal_thyroid_gland2.66476717
12MP0005503_abnormal_tendon_morphology2.51586965
13MP0002132_abnormal_respiratory_system2.23103713
14MP0006054_spinal_hemorrhage2.01855423
15MP0001348_abnormal_lacrimal_gland1.96944032
16MP0005551_abnormal_eye_electrophysiolog1.87975861
17MP0006035_abnormal_mitochondrial_morpho1.77277546
18MP0001501_abnormal_sleep_pattern1.76836366
19MP0003880_abnormal_central_pattern1.73695500
20MP0008775_abnormal_heart_ventricle1.69419875
21MP0001346_abnormal_lacrimal_gland1.67949149
22MP0000678_abnormal_parathyroid_gland1.62656318
23MP0005397_hematopoietic_system_phenotyp1.60172275
24MP0001545_abnormal_hematopoietic_system1.60172275
25MP0003045_fibrosis1.57229019
26MP0005646_abnormal_pituitary_gland1.53915616
27MP0006276_abnormal_autonomic_nervous1.53375553
28MP0003638_abnormal_response/metabolism_1.53370392
29MP0004885_abnormal_endolymph1.51118683
30MP0003941_abnormal_skin_development1.48934498
31MP0009764_decreased_sensitivity_to1.42347476
32MP0004381_abnormal_hair_follicle1.41345185
33MP0001664_abnormal_digestion1.39374275
34MP0004130_abnormal_muscle_cell1.38618582
35MP0008057_abnormal_DNA_replication1.37224595
36MP0004782_abnormal_surfactant_physiolog1.31698140
37MP0009333_abnormal_splenocyte_physiolog1.27924194
38MP0002249_abnormal_larynx_morphology1.27469394
39MP0003938_abnormal_ear_development1.24635102
40MP0000049_abnormal_middle_ear1.14128819
41MP0005187_abnormal_penis_morphology1.13621569
42MP0005310_abnormal_salivary_gland1.13421434
43MP0009765_abnormal_xenobiotic_induced1.13366345
44MP0000230_abnormal_systemic_arterial1.11204560
45MP0003633_abnormal_nervous_system1.06053685
46MP0006072_abnormal_retinal_apoptosis1.03619228
47MP0003567_abnormal_fetal_cardiomyocyte1.03486509
48MP0003646_muscle_fatigue1.03359495
49MP0000569_abnormal_digit_pigmentation0.96569152
50MP0008875_abnormal_xenobiotic_pharmacok0.93373750
51MP0001485_abnormal_pinna_reflex0.91335018
52MP0005645_abnormal_hypothalamus_physiol0.91240167
53MP0008877_abnormal_DNA_methylation0.90949739
54MP0008872_abnormal_physiological_respon0.89074403
55MP0002909_abnormal_adrenal_gland0.88154412
56MP0009745_abnormal_behavioral_response0.87419786
57MP0000685_abnormal_immune_system0.86455225
58MP0001486_abnormal_startle_reflex0.85212356
59MP0001270_distended_abdomen0.84442217
60MP0009046_muscle_twitch0.84029810
61MP0002733_abnormal_thermal_nociception0.81969974
62MP0005670_abnormal_white_adipose0.79196275
63MP0000383_abnormal_hair_follicle0.79167953
64MP0003195_calcinosis0.77123557
65MP0001963_abnormal_hearing_physiology0.75743002
66MP0002272_abnormal_nervous_system0.73314358
67MP0002168_other_aberrant_phenotype0.70493386
68MP0002148_abnormal_hypersensitivity_rea0.70131792
69MP0004147_increased_porphyrin_level0.68845647
70MP0002693_abnormal_pancreas_physiology0.67974362
71MP0003718_maternal_effect0.65514470
72MP0004085_abnormal_heartbeat0.65138023
73MP0001851_eye_inflammation0.63440680
74MP0005410_abnormal_fertilization0.62752272
75MP0005253_abnormal_eye_physiology0.61903146
76MP0000647_abnormal_sebaceous_gland0.61386424
77MP0003959_abnormal_lean_body0.61229981
78MP0003183_abnormal_peptide_metabolism0.60724693
79MP0010678_abnormal_skin_adnexa0.59563200
80MP0009672_abnormal_birth_weight0.59323455
81MP0003631_nervous_system_phenotype0.59223599
82MP0003937_abnormal_limbs/digits/tail_de0.58471007
83MP0001970_abnormal_pain_threshold0.57333938
84MP0001881_abnormal_mammary_gland0.57194109
85MP0005395_other_phenotype0.55828985
86MP0001756_abnormal_urination0.54951299
87MP0002736_abnormal_nociception_after0.52997416
88MP0002971_abnormal_brown_adipose0.51651727
89MP0006036_abnormal_mitochondrial_physio0.49535251
90MP0002557_abnormal_social/conspecific_i0.46579139
91MP0010030_abnormal_orbit_morphology0.46468208
92MP0004742_abnormal_vestibular_system0.45927483
93MP0005334_abnormal_fat_pad0.45551635
94MP0009384_cardiac_valve_regurgitation0.45012950
95MP0002572_abnormal_emotion/affect_behav0.43532014
96MP0005167_abnormal_blood-brain_barrier0.43438239
97MP0002998_abnormal_bone_remodeling0.43018540
98MP0002653_abnormal_ependyma_morphology0.42949560
99MP0002229_neurodegeneration0.41790338
100MP0005195_abnormal_posterior_eye0.41516863

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)5.79653828
2Intestinal atresia (HP:0011100)5.55977616
3Pancreatic islet-cell hyperplasia (HP:0004510)5.23780420
4Mesangial abnormality (HP:0001966)5.04268852
5Abnormality of the aortic arch (HP:0012303)4.63891476
6Oligodontia (HP:0000677)4.60771577
7Broad alveolar ridges (HP:0000187)4.57147444
8Large for gestational age (HP:0001520)4.41520431
9Type II lissencephaly (HP:0007260)4.36408910
10Severe visual impairment (HP:0001141)4.13629380
11Thickened helices (HP:0000391)4.03749969
12Concave nail (HP:0001598)3.84615820
13Tubular atrophy (HP:0000092)3.71346830
14Congenital stationary night blindness (HP:0007642)3.69186179
15Gaze-evoked nystagmus (HP:0000640)3.68362875
16Abnormality of the ileum (HP:0001549)3.64869250
17Hypoproteinemia (HP:0003075)3.63034880
18Abnormality of endocrine pancreas physiology (HP:0012093)3.55117179
19Abnormality of the pancreatic islet cells (HP:0006476)3.55117179
20Congenital ichthyosiform erythroderma (HP:0007431)3.44453927
21Cerebellar dysplasia (HP:0007033)3.38641353
22Neonatal respiratory distress (HP:0002643)3.15974112
23Autoimmune hemolytic anemia (HP:0001890)3.13960233
24Abnormal rod and cone electroretinograms (HP:0008323)3.13103812
25Gastrointestinal atresia (HP:0002589)3.08469150
26Keratoconjunctivitis sicca (HP:0001097)2.93246435
27Conical tooth (HP:0000698)2.92785205
28Keratoconjunctivitis (HP:0001096)2.89217370
29Premature skin wrinkling (HP:0100678)2.88244086
30Nephroblastoma (Wilms tumor) (HP:0002667)2.83676550
31Focal motor seizures (HP:0011153)2.76284886
32Increased connective tissue (HP:0009025)2.73898397
33Poor head control (HP:0002421)2.71666986
34Embryonal renal neoplasm (HP:0011794)2.71652994
35Optic nerve hypoplasia (HP:0000609)2.70927157
36Attenuation of retinal blood vessels (HP:0007843)2.69211084
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69176736
38Abnormality of macular pigmentation (HP:0008002)2.68479226
39Lissencephaly (HP:0001339)2.66896792
40Agitation (HP:0000713)2.60253329
41Focal seizures (HP:0007359)2.53434683
42Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.42464229
43Hyperthyroidism (HP:0000836)2.40714902
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.40619766
45Hypoplasia of the fovea (HP:0007750)2.40619766
46Poor speech (HP:0002465)2.39554214
47Chromsome breakage (HP:0040012)2.38827301
48True hermaphroditism (HP:0010459)2.38294096
49Abnormality of the vitreous humor (HP:0004327)2.34198237
50Soft skin (HP:0000977)2.32286522
51Short chin (HP:0000331)2.30026497
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29883220
5311 pairs of ribs (HP:0000878)2.25732318
54Pigmentary retinal degeneration (HP:0001146)2.25577086
55Central scotoma (HP:0000603)2.24871486
56Autoimmune thrombocytopenia (HP:0001973)2.21761314
57Large eyes (HP:0001090)2.21032682
58Absent eyebrow (HP:0002223)2.18642026
59Aplasia/Hypoplasia of the brainstem (HP:0007362)2.17869425
60Hypoplasia of the brainstem (HP:0002365)2.17869425
61Myositis (HP:0100614)2.17135883
62Muscular dystrophy (HP:0003560)2.14560772
63Hemiparesis (HP:0001269)2.14265021
64Goiter (HP:0000853)2.13100116
65Anhidrosis (HP:0000970)2.13090404
66Bile duct proliferation (HP:0001408)2.11785142
67Abnormal biliary tract physiology (HP:0012439)2.11785142
68Orchitis (HP:0100796)2.09105063
69Bony spicule pigmentary retinopathy (HP:0007737)2.08328010
70Progressive inability to walk (HP:0002505)2.04575725
71Decreased central vision (HP:0007663)2.04259750
72Abnormality of the alveolar ridges (HP:0006477)2.03236454
73Broad-based gait (HP:0002136)2.01497873
74Tented upper lip vermilion (HP:0010804)2.01115523
75Keratitis (HP:0000491)2.00728877
76Thyroid-stimulating hormone excess (HP:0002925)10.0480555
77Non-midline cleft lip (HP:0100335)1.96218251
78Scotoma (HP:0000575)1.95527724
79Type I diabetes mellitus (HP:0100651)1.95193067
80Hypoplasia of the pons (HP:0012110)1.91942861
81Retinal dysplasia (HP:0007973)1.91428938
82Cone-rod dystrophy (HP:0000548)1.90075954
833-Methylglutaconic aciduria (HP:0003535)1.88464236
84Gastrointestinal dysmotility (HP:0002579)1.88281634
85Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.86834995
86Nonprogressive disorder (HP:0003680)1.86789960
87Abnormality of the fovea (HP:0000493)1.83850949
88Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.82784925
89Severe Myopia (HP:0011003)1.82701800
90Hypoplastic nipples (HP:0002557)1.82200722
91Long nose (HP:0003189)1.80831204
92Increased IgM level (HP:0003496)1.77666226
93Abnormal pupillary function (HP:0007686)1.77219337
94Pancreatic cysts (HP:0001737)1.77065192
95Hyperpituitarism (HP:0010514)1.76395654
96Impulsivity (HP:0100710)1.75680222
97Pendular nystagmus (HP:0012043)1.73015770
98Brittle hair (HP:0002299)1.71671771
99Hypoplastic iliac wings (HP:0002866)1.70253650
100Hydroxyprolinuria (HP:0003080)1.70099677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK28.83940433
2FRK6.04358656
3BUB13.34420383
4PINK13.31646090
5IRAK33.09820852
6PNCK3.09564026
7TRIM283.08017199
8BCR2.85876006
9ERN12.76525911
10MAP3K102.25121583
11ADRBK12.10448553
12WEE11.83550196
13CDK121.74251199
14TAF11.69435885
15PRKCG1.57210405
16MST41.40100229
17PLK21.37462619
18GRK11.37431551
19ERBB21.35843179
20KIT1.28903981
21STK31.27949081
22PRKCE1.22129602
23VRK21.14625703
24CLK11.13947674
25ACVR1B1.11203251
26IRAK10.93143269
27DYRK30.90769328
28NEK10.90505650
29CDK190.88735339
30MKNK20.87249920
31EIF2AK20.85765412
32TYRO30.82348784
33BMPR1B0.81853371
34TGFBR10.77961817
35OXSR10.73839605
36CAMK2A0.69560746
37PLK40.69435134
38CAMK1G0.68696377
39TEC0.66797945
40MAPK110.66551827
41MKNK10.63616263
42AURKB0.60914853
43NUAK10.59674001
44DYRK1A0.59548315
45NEK20.58719172
46WNK30.54599343
47BRSK10.53990959
48PRKCI0.51515975
49CSNK1A10.50989069
50MET0.50698590
51DAPK20.49699458
52NEK90.48910951
53PRKCB0.46605654
54MAP2K70.45195844
55RIPK10.43971425
56EPHA20.42933624
57CSNK2A20.41887571
58MAPKAPK50.41270111
59FGFR10.40761190
60INSRR0.39316576
61TXK0.39196391
62STK380.38991597
63ATM0.38764387
64GRK50.35858590
65PLK10.34943088
66CSNK2A10.33583223
67DYRK20.33511906
68STK100.33145633
69PTK2B0.32720498
70MAPK10.32425169
71STK390.31425132
72AKT10.31115407
73CAMK10.30984768
74MAP4K20.30046283
75CDK150.29796828
76CSNK1G30.29794826
77CDK11A0.29595152
78ATR0.29315525
79PAK30.28567973
80CDK180.27613190
81ROCK10.27081612
82CAMK2D0.26993099
83ABL10.26709798
84AKT20.26463726
85RPS6KA30.26134259
86CSNK1E0.26083982
87PRKCA0.26081131
88MELK0.26077785
89CSNK1A1L0.25958384
90PRKACG0.25229717
91TRPM70.24832489
92CDK50.24571511
93GSK3B0.24462076
94CDK20.24055228
95NTRK20.23891220
96CHUK0.23761663
97SGK10.23451198
98PRKDC0.22805501
99CDK10.22651087
100MAPK80.21871990

Predicted pathways (KEGG)

RankGene SetZ-score
1Tryptophan metabolism_Homo sapiens_hsa003803.32684904
2Olfactory transduction_Homo sapiens_hsa047403.13730544
3Neuroactive ligand-receptor interaction_Homo sapiens_hsa040803.07857960
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.61414082
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.59953771
6Pentose phosphate pathway_Homo sapiens_hsa000302.59093584
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.45743800
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.38620243
9Dorso-ventral axis formation_Homo sapiens_hsa043202.36674188
10Phototransduction_Homo sapiens_hsa047442.32251727
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.28146550
12Morphine addiction_Homo sapiens_hsa050322.17115605
13Basal transcription factors_Homo sapiens_hsa030221.96452912
14Homologous recombination_Homo sapiens_hsa034401.92988368
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90770025
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87257042
17Nicotine addiction_Homo sapiens_hsa050331.81140571
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75997750
19Salivary secretion_Homo sapiens_hsa049701.72873266
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71549295
21Fanconi anemia pathway_Homo sapiens_hsa034601.64624297
22Caffeine metabolism_Homo sapiens_hsa002321.63692616
23Butanoate metabolism_Homo sapiens_hsa006501.50469060
24ABC transporters_Homo sapiens_hsa020101.39125318
25Circadian entrainment_Homo sapiens_hsa047131.38826928
26Arginine and proline metabolism_Homo sapiens_hsa003301.38272738
27Glycerolipid metabolism_Homo sapiens_hsa005611.32328020
28Taste transduction_Homo sapiens_hsa047421.24303833
29Graft-versus-host disease_Homo sapiens_hsa053321.23024004
30Chemical carcinogenesis_Homo sapiens_hsa052041.21400741
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21111075
32Calcium signaling pathway_Homo sapiens_hsa040201.18181384
33Linoleic acid metabolism_Homo sapiens_hsa005911.18133273
34Sulfur relay system_Homo sapiens_hsa041221.16448388
35Retinol metabolism_Homo sapiens_hsa008301.16189546
36Allograft rejection_Homo sapiens_hsa053301.15350007
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15091950
38Arachidonic acid metabolism_Homo sapiens_hsa005901.14058087
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.11796861
40One carbon pool by folate_Homo sapiens_hsa006701.11401319
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06990654
42African trypanosomiasis_Homo sapiens_hsa051431.04976931
43Autoimmune thyroid disease_Homo sapiens_hsa053201.04478191
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03517468
45Mineral absorption_Homo sapiens_hsa049781.00321699
46Renin secretion_Homo sapiens_hsa049240.99271773
47Fatty acid degradation_Homo sapiens_hsa000710.98791730
48Non-homologous end-joining_Homo sapiens_hsa034500.94948188
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93772420
50Ovarian steroidogenesis_Homo sapiens_hsa049130.93008447
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.89370749
52Complement and coagulation cascades_Homo sapiens_hsa046100.89275863
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.87286031
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86345227
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.83654086
56GABAergic synapse_Homo sapiens_hsa047270.83376348
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81379363
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80573683
59Asthma_Homo sapiens_hsa053100.80527651
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.78615905
61Starch and sucrose metabolism_Homo sapiens_hsa005000.77805439
62Sphingolipid metabolism_Homo sapiens_hsa006000.77449813
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76738317
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75513346
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74159087
66Type I diabetes mellitus_Homo sapiens_hsa049400.73895106
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73149924
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73117652
69Purine metabolism_Homo sapiens_hsa002300.71209723
70Histidine metabolism_Homo sapiens_hsa003400.65127872
71Nitrogen metabolism_Homo sapiens_hsa009100.63641595
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63541139
73Glutathione metabolism_Homo sapiens_hsa004800.63242633
74Fatty acid biosynthesis_Homo sapiens_hsa000610.62867367
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62769569
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.60125937
77Long-term depression_Homo sapiens_hsa047300.59057165
78Pyrimidine metabolism_Homo sapiens_hsa002400.58170293
79Biosynthesis of amino acids_Homo sapiens_hsa012300.56343449
80Metabolic pathways_Homo sapiens_hsa011000.55081457
81Arginine biosynthesis_Homo sapiens_hsa002200.54002557
82RNA polymerase_Homo sapiens_hsa030200.53979722
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52442491
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.50037788
85Glutamatergic synapse_Homo sapiens_hsa047240.49423837
86Serotonergic synapse_Homo sapiens_hsa047260.49363913
87RNA degradation_Homo sapiens_hsa030180.46508974
88Hedgehog signaling pathway_Homo sapiens_hsa043400.46445955
89Lysine degradation_Homo sapiens_hsa003100.44358437
90cAMP signaling pathway_Homo sapiens_hsa040240.41687327
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.40482449
92ECM-receptor interaction_Homo sapiens_hsa045120.39181246
93Oxytocin signaling pathway_Homo sapiens_hsa049210.36153205
94Legionellosis_Homo sapiens_hsa051340.36130109
95Insulin secretion_Homo sapiens_hsa049110.35003054
96Ether lipid metabolism_Homo sapiens_hsa005650.34785657
97Basal cell carcinoma_Homo sapiens_hsa052170.34212283
98DNA replication_Homo sapiens_hsa030300.31161867
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30266704
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28184375

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