ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	platelet dense granule organization (GO:0060155)	5.29613565
2	ketone body metabolic process (GO:1902224)	4.26416955
3	cellular ketone body metabolic process (GO:0046950)	4.16099627
4	respiratory chain complex IV assembly (GO:0008535)	4.09651582
5	cytochrome complex assembly (GO:0017004)	4.04001183
6	inositol phosphate catabolic process (GO:0071545)	3.98424636
7	cullin deneddylation (GO:0010388)	3.97971993
8	proteasome assembly (GO:0043248)	3.84745930
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.83926132
10	DNA deamination (GO:0045006)	3.83416664
11	protein complex biogenesis (GO:0070271)	3.78523450
12	positive regulation of growth hormone secretion (GO:0060124)	3.75706053
13	prenylation (GO:0097354)	3.72941255
14	protein prenylation (GO:0018342)	3.72941255
15	response to pheromone (GO:0019236)	3.68478020
16	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.65714158
17	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.57769474
18	inositol phosphate dephosphorylation (GO:0046855)	3.57769474
19	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.52132181
20	rRNA methylation (GO:0031167)	3.43556898
21	replication fork processing (GO:0031297)	3.39420311
22	mitochondrial respiratory chain complex assembly (GO:0033108)	3.38499917
23	positive regulation of steroid hormone secretion (GO:2000833)	3.36272192
24	protein deneddylation (GO:0000338)	3.35147461
25	polyol catabolic process (GO:0046174)	3.28974747
26	protein K6-linked ubiquitination (GO:0085020)	3.21958544
27	adult feeding behavior (GO:0008343)	3.21862756
28	intraciliary transport (GO:0042073)	3.19618977
29	S-adenosylmethionine metabolic process (GO:0046500)	3.18536845
30	rRNA modification (GO:0000154)	3.11346809
31	endocrine hormone secretion (GO:0060986)	3.07345548
32	lactate metabolic process (GO:0006089)	3.07014916
33	anterograde synaptic vesicle transport (GO:0048490)	3.03642692
34	signal peptide processing (GO:0006465)	3.03249763
35	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.01297322
36	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.01297322
37	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.01297322
38	regulation of coenzyme metabolic process (GO:0051196)	2.96687184
39	regulation of cofactor metabolic process (GO:0051193)	2.96687184
40	protein polyglutamylation (GO:0018095)	2.96666298
41	branched-chain amino acid catabolic process (GO:0009083)	2.95858626
42	endosome to pigment granule transport (GO:0043485)	2.92356116
43	endosome to melanosome transport (GO:0035646)	2.92356116
44	regulation of growth hormone secretion (GO:0060123)	2.87284383
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.86438089
46	NADH dehydrogenase complex assembly (GO:0010257)	2.86438089
47	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.86438089
48	preassembly of GPI anchor in ER membrane (GO:0016254)	2.86009172
49	regulation of sulfur metabolic process (GO:0042762)	2.84907042
50	regulation of glucokinase activity (GO:0033131)	2.83861898
51	regulation of hexokinase activity (GO:1903299)	2.83861898
52	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.83507941
53	microtubule severing (GO:0051013)	2.82798900
54	adenosine metabolic process (GO:0046085)	2.77720257
55	glycosphingolipid biosynthetic process (GO:0006688)	2.76344469
56	axoneme assembly (GO:0035082)	2.76284039
57	protein-cofactor linkage (GO:0018065)	2.71368415
58	vascular smooth muscle contraction (GO:0014829)	2.70638154
59	regulation of glucocorticoid secretion (GO:2000849)	2.68022692
60	C-terminal protein amino acid modification (GO:0018410)	2.67982798
61	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.66991772
62	histone H2A acetylation (GO:0043968)	2.66991579
63	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.66906706
64	growth hormone secretion (GO:0030252)	2.66436823
65	C-terminal protein lipidation (GO:0006501)	2.64479093
66	DNA integration (GO:0015074)	2.62966781
67	regulation of cilium movement (GO:0003352)	2.56715153
68	ribonucleoprotein complex disassembly (GO:0032988)	2.56291610
69	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.55569533
70	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.55131212
71	cytidine metabolic process (GO:0046087)	2.54431194
72	cytidine catabolic process (GO:0006216)	2.54431194
73	cytidine deamination (GO:0009972)	2.54431194
74	mannosylation (GO:0097502)	2.53706060
75	positive regulation of glycolytic process (GO:0045821)	2.52728520
76	negative regulation of neurological system process (GO:0031645)	2.51989974
77	intra-Golgi vesicle-mediated transport (GO:0006891)	2.51307013
78	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.51118357
79	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.49813113
80	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.49331767
81	fucose catabolic process (GO:0019317)	2.48240413
82	L-fucose metabolic process (GO:0042354)	2.48240413
83	L-fucose catabolic process (GO:0042355)	2.48240413
84	regulation of acrosome reaction (GO:0060046)	2.47004354
85	double-strand break repair via homologous recombination (GO:0000724)	2.46426289
86	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.45929969
87	positive regulation of insulin secretion (GO:0032024)	2.45792437
88	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.45576329
89	recombinational repair (GO:0000725)	2.44747579
90	cell wall macromolecule catabolic process (GO:0016998)	2.44495679
91	atrial cardiac muscle cell action potential (GO:0086014)	2.43855832
92	proline transport (GO:0015824)	2.42680657
93	amino-acid betaine metabolic process (GO:0006577)	2.42207682
94	negative regulation of heart rate (GO:0010459)	2.37849921
95	keratinocyte development (GO:0003334)	2.37070996
96	positive regulation of mitochondrial fission (GO:0090141)	2.36621780
97	cilium morphogenesis (GO:0060271)	2.36216616
98	negative regulation of execution phase of apoptosis (GO:1900118)	2.36150082
99	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.35354096
100	isotype switching (GO:0045190)	2.35354096

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.12270977
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.01687812
3	VDR_22108803_ChIP-Seq_LS180_Human	2.98361246
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.95644326
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.69083441
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.66001083
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.51970225
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.43307166
9	FUS_26573619_Chip-Seq_HEK293_Human	2.35089091
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.30286263
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.24584413
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21816454
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.18907187
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11244708
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.09752998
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.08847878
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.08432901
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.06312978
19	EWS_26573619_Chip-Seq_HEK293_Human	2.06302939
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.98621584
21	P300_19829295_ChIP-Seq_ESCs_Human	1.94155986
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.93022879
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.91037364
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.90381888
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.73345523
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.73129675
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.70930752
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.69991073
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.68698471
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.68293076
31	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.67634340
32	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.63370613
33	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.60745528
34	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.58954800
35	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.56801837
36	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.52722937
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.52582606
38	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.52510983
39	STAT3_23295773_ChIP-Seq_U87_Human	1.52384717
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.51133189
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49927873
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49874356
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.44244111
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.43710891
45	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.42828640
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42686380
47	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.40486022
48	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.40374724
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.40102115
50	AR_25329375_ChIP-Seq_VCAP_Human	1.39685394
51	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.39175019
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.37313284
53	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36716351
54	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.36593554
55	TCF4_23295773_ChIP-Seq_U87_Human	1.35370903
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.34789239
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34789239
58	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.34427216
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34272226
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34272226
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.33523793
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31027748
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.30883820
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30208373
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.25074559
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.22670932
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21189125
68	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.21152356
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20063696
70	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.20054537
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.20014294
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.17386786
73	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.15579058
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14969301
75	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.14569418
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.14104409
77	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13523497
78	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13317874
79	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.12811130
80	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.11245286
81	MYC_18940864_ChIP-ChIP_HL60_Human	1.10311375
82	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.10232393
83	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09822339
84	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09448173
85	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.09225733
86	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09113312
87	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.08345866
88	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08002982
89	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.07923298
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06713792
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06438102
92	P300_18555785_Chip-Seq_ESCs_Mouse	1.05500510
93	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.03172162
94	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.02889804
95	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02759385
96	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.02624988
97	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02393203
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02393203
99	FOXP3_21729870_ChIP-Seq_TREG_Human	1.01908095
100	AR_20517297_ChIP-Seq_VCAP_Human	1.01284854

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.39769019
2	MP0000372_irregular_coat_pigmentation	3.69904136
3	MP0002837_dystrophic_cardiac_calcinosis	3.54966603
4	MP0003195_calcinosis	3.08423934
5	MP0006072_abnormal_retinal_apoptosis	2.53561018
6	MP0005253_abnormal_eye_physiology	2.50232706
7	MP0005075_abnormal_melanosome_morpholog	2.33091419
8	MP0008058_abnormal_DNA_repair	2.23708828
9	MP0001984_abnormal_olfaction	2.23402389
10	MP0003122_maternal_imprinting	2.21954281
11	MP0000015_abnormal_ear_pigmentation	2.18085898
12	MP0002876_abnormal_thyroid_physiology	2.15774608
13	MP0008877_abnormal_DNA_methylation	2.10422355
14	MP0005551_abnormal_eye_electrophysiolog	2.01114880
15	MP0005174_abnormal_tail_pigmentation	1.99086688
16	MP0003950_abnormal_plasma_membrane	1.96558696
17	MP0003787_abnormal_imprinting	1.92529243
18	MP0005171_absent_coat_pigmentation	1.90665478
19	MP0006036_abnormal_mitochondrial_physio	1.81439285
20	MP0009780_abnormal_chondrocyte_physiolo	1.79421039
21	MP0002095_abnormal_skin_pigmentation	1.78910257
22	MP0002254_reproductive_system_inflammat	1.78104103
23	MP0004215_abnormal_myocardial_fiber	1.76425652
24	MP0005645_abnormal_hypothalamus_physiol	1.76119684
25	MP0004142_abnormal_muscle_tone	1.70396637
26	MP0003646_muscle_fatigue	1.64830832
27	MP0006035_abnormal_mitochondrial_morpho	1.64276868
28	MP0005408_hypopigmentation	1.58748252
29	MP0009046_muscle_twitch	1.54225100
30	MP0000569_abnormal_digit_pigmentation	1.52576177
31	MP0005187_abnormal_penis_morphology	1.47947023
32	MP0002090_abnormal_vision	1.43637590
33	MP0004043_abnormal_pH_regulation	1.42802190
34	MP0004885_abnormal_endolymph	1.39971643
35	MP0005379_endocrine/exocrine_gland_phen	1.39534067
36	MP0002163_abnormal_gland_morphology	1.39407914
37	MP0008872_abnormal_physiological_respon	1.38214356
38	MP0004145_abnormal_muscle_electrophysio	1.37778161
39	MP0009745_abnormal_behavioral_response	1.36200582
40	MP0002272_abnormal_nervous_system	1.34545391
41	MP0000427_abnormal_hair_cycle	1.33912333
42	MP0009697_abnormal_copulation	1.32396943
43	MP0001324_abnormal_eye_pigmentation	1.31171813
44	MP0003121_genomic_imprinting	1.31106302
45	MP0005248_abnormal_Harderian_gland	1.28790934
46	MP0001764_abnormal_homeostasis	1.26691223
47	MP0001986_abnormal_taste_sensitivity	1.25592139
48	MP0010094_abnormal_chromosome_stability	1.21963473
49	MP0002909_abnormal_adrenal_gland	1.21530174
50	MP0004134_abnormal_chest_morphology	1.21079095
51	MP0003136_yellow_coat_color	1.19489553
52	MP0008775_abnormal_heart_ventricle	1.19221988
53	MP0002638_abnormal_pupillary_reflex	1.19063113
54	MP0000371_diluted_coat_color	1.18393986
55	MP0003137_abnormal_impulse_conducting	1.18259246
56	MP0002693_abnormal_pancreas_physiology	1.18016949
57	MP0010386_abnormal_urinary_bladder	1.16168572
58	MP0002736_abnormal_nociception_after	1.14544075
59	MP0005646_abnormal_pituitary_gland	1.11406935
60	MP0001486_abnormal_startle_reflex	1.09174811
61	MP0003806_abnormal_nucleotide_metabolis	1.08853653
62	MP0004147_increased_porphyrin_level	1.08564858
63	MP0000516_abnormal_urinary_system	1.07996121
64	MP0005367_renal/urinary_system_phenotyp	1.07996121
65	MP0002938_white_spotting	1.05896962
66	MP0001968_abnormal_touch/_nociception	1.03856415
67	MP0002229_neurodegeneration	1.03347063
68	MP0001944_abnormal_pancreas_morphology	1.00376006
69	MP0001905_abnormal_dopamine_level	0.99754168
70	MP0005636_abnormal_mineral_homeostasis	0.98232136
71	MP0000749_muscle_degeneration	0.97690640
72	MP0000358_abnormal_cell_content/	0.94709532
73	MP0005332_abnormal_amino_acid	0.94067902
74	MP0002138_abnormal_hepatobiliary_system	0.93254987
75	MP0005084_abnormal_gallbladder_morpholo	0.91636831
76	MP0004924_abnormal_behavior	0.90540328
77	MP0005386_behavior/neurological_phenoty	0.90540328
78	MP0003718_maternal_effect	0.90495349
79	MP0001529_abnormal_vocalization	0.89337109
80	MP0002751_abnormal_autonomic_nervous	0.86849701
81	MP0003186_abnormal_redox_activity	0.84397296
82	MP0003172_abnormal_lysosome_physiology	0.83967752
83	MP0001501_abnormal_sleep_pattern	0.83880287
84	MP0004484_altered_response_of	0.83663920
85	MP0004270_analgesia	0.82335464
86	MP0001756_abnormal_urination	0.81874770
87	MP0002734_abnormal_mechanical_nocicepti	0.81673390
88	MP0003786_premature_aging	0.81528614
89	MP0004084_abnormal_cardiac_muscle	0.81508610
90	MP0005220_abnormal_exocrine_pancreas	0.79116740
91	MP0002078_abnormal_glucose_homeostasis	0.77917710
92	MP0004085_abnormal_heartbeat	0.76727417
93	MP0002067_abnormal_sensory_capabilities	0.76059611
94	MP0004381_abnormal_hair_follicle	0.75835573
95	MP0001970_abnormal_pain_threshold	0.74926379
96	MP0003880_abnormal_central_pattern	0.74894547
97	MP0008875_abnormal_xenobiotic_pharmacok	0.73575555
98	MP0005195_abnormal_posterior_eye	0.73535769
99	MP0002064_seizures	0.73178707
100	MP0003045_fibrosis	0.72523642

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intestinal atresia (HP:0011100)	4.25305350
2	Acute necrotizing encephalopathy (HP:0006965)	3.55491101
3	Progressive macrocephaly (HP:0004481)	3.51797803
4	Renal cortical cysts (HP:0000803)	3.37922335
5	Abnormality of midbrain morphology (HP:0002418)	3.21959091
6	Molar tooth sign on MRI (HP:0002419)	3.21959091
7	Mitochondrial inheritance (HP:0001427)	3.18887481
8	Increased CSF lactate (HP:0002490)	3.15870447
9	Acute encephalopathy (HP:0006846)	3.12586927
10	Abnormality of the renal cortex (HP:0011035)	3.07582607
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.06644439
12	Hypoglycemic coma (HP:0001325)	3.05443937
13	Hepatic necrosis (HP:0002605)	3.03646449
14	Albinism (HP:0001022)	3.00534604
15	Hepatocellular necrosis (HP:0001404)	2.99207336
16	Hypothermia (HP:0002045)	2.93687375
17	Ketoacidosis (HP:0001993)	2.77311817
18	Pancreatic cysts (HP:0001737)	2.73480123
19	Medial flaring of the eyebrow (HP:0010747)	2.73450614
20	Abnormality of the labia minora (HP:0012880)	2.70005968
21	Nephronophthisis (HP:0000090)	2.69328413
22	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.66076721
23	Hypoplasia of the fovea (HP:0007750)	2.66076721
24	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.66024842
25	3-Methylglutaconic aciduria (HP:0003535)	2.59354692
26	Congenital stationary night blindness (HP:0007642)	2.58293665
27	Methylmalonic acidemia (HP:0002912)	2.57887546
28	Hyperinsulinemic hypoglycemia (HP:0000825)	2.56547019
29	Gaze-evoked nystagmus (HP:0000640)	2.52603257
30	Abnormality of the renal medulla (HP:0100957)	2.51381910
31	Abnormality of vitamin B metabolism (HP:0004340)	2.50775188
32	Hemiparesis (HP:0001269)	2.50683105
33	Hyperventilation (HP:0002883)	2.50039572
34	Progressive inability to walk (HP:0002505)	2.43020615
35	Oligodactyly (hands) (HP:0001180)	2.39477956
36	Short tibia (HP:0005736)	2.39359936
37	Hypoglycemic seizures (HP:0002173)	2.39075567
38	Pancreatic fibrosis (HP:0100732)	2.35059895
39	Respiratory failure (HP:0002878)	2.32248768
40	Neoplasm of the adrenal cortex (HP:0100641)	2.32108510
41	Large for gestational age (HP:0001520)	2.31745568
42	Gastrointestinal atresia (HP:0002589)	2.23617353
43	Cerebral edema (HP:0002181)	2.20624701
44	True hermaphroditism (HP:0010459)	2.18899374
45	Abnormality of the fovea (HP:0000493)	2.17677523
46	Thyroiditis (HP:0100646)	2.15663153
47	Tongue fasciculations (HP:0001308)	2.12678368
48	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.12620800
49	Tubulointerstitial nephritis (HP:0001970)	2.11376129
50	Abnormality of methionine metabolism (HP:0010901)	2.09282372
51	Gait imbalance (HP:0002141)	2.04314008
52	Congenital primary aphakia (HP:0007707)	2.02782725
53	Disproportionate short-trunk short stature (HP:0003521)	2.02255657
54	Optic disc pallor (HP:0000543)	1.98688342
55	Congenital hepatic fibrosis (HP:0002612)	1.97696554
56	Fair hair (HP:0002286)	1.97679303
57	Polyphagia (HP:0002591)	1.97625760
58	Febrile seizures (HP:0002373)	1.96248846
59	Hyperglycemia (HP:0003074)	1.95568656
60	Metaphyseal dysplasia (HP:0100255)	1.94430745
61	Nephrogenic diabetes insipidus (HP:0009806)	1.94005755
62	Lactic acidosis (HP:0003128)	1.93095335
63	Increased hepatocellular lipid droplets (HP:0006565)	1.92544565
64	Broad-based gait (HP:0002136)	1.92391399
65	Generalized hypopigmentation (HP:0007513)	1.90184857
66	Cutaneous melanoma (HP:0012056)	1.88924672
67	Methylmalonic aciduria (HP:0012120)	1.87841808
68	Hypoplastic iliac wings (HP:0002866)	1.87705291
69	CNS demyelination (HP:0007305)	1.87298343
70	Attenuation of retinal blood vessels (HP:0007843)	1.86512687
71	Aqueductal stenosis (HP:0002410)	1.85480970
72	Inability to walk (HP:0002540)	1.84928149
73	Neoplasm of the adrenal gland (HP:0100631)	1.84610121
74	Hypoproteinemia (HP:0003075)	1.83973790
75	Type 2 muscle fiber atrophy (HP:0003554)	1.83504263
76	Increased serum lactate (HP:0002151)	1.83144552
77	Median cleft lip (HP:0000161)	1.82363776
78	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.80783949
79	Abnormal protein N-linked glycosylation (HP:0012347)	1.80783949
80	Abnormal protein glycosylation (HP:0012346)	1.80783949
81	Abnormal glycosylation (HP:0012345)	1.80783949
82	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.79707537
83	Calf muscle hypertrophy (HP:0008981)	1.79560949
84	Pancreatic islet-cell hyperplasia (HP:0004510)	1.78919859
85	Lipid accumulation in hepatocytes (HP:0006561)	1.78159469
86	Ketosis (HP:0001946)	1.77416150
87	Lethargy (HP:0001254)	1.76477406
88	Enlarged penis (HP:0000040)	1.76477079
89	Abnormality of the metopic suture (HP:0005556)	1.76023453
90	Opisthotonus (HP:0002179)	1.75891272
91	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.75410356
92	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.75159470
93	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.75159470
94	Delayed gross motor development (HP:0002194)	1.74380179
95	Thyroid carcinoma (HP:0002890)	1.73965280
96	Aplasia/Hypoplasia of the macula (HP:0008059)	1.71609911
97	Postaxial hand polydactyly (HP:0001162)	1.70068379
98	Hypokinesia (HP:0002375)	1.69461867
99	Abnormality of urine glucose concentration (HP:0011016)	1.68816846
100	Glycosuria (HP:0003076)	1.68816846

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.54057750
2	MAP4K2	3.78733368
3	MST4	2.73584069
4	MUSK	2.38913870
5	WNK3	2.36808116
6	MAP3K12	2.27840785
7	MAP3K4	2.25403814
8	STK38L	2.10119320
9	PLK2	2.03544336
10	NUAK1	2.03198040
11	EIF2AK3	1.93568524
12	EIF2AK1	1.92796911
13	PHKG2	1.86816332
14	PHKG1	1.86816332
15	GRK1	1.81700940
16	MKNK2	1.71472840
17	PAK3	1.69657282
18	TRIM28	1.62998533
19	BMPR1B	1.61913189
20	CASK	1.54343899
21	STK39	1.53890761
22	BMPR2	1.51263489
23	ERBB3	1.45770896
24	DAPK2	1.45196606
25	PLK3	1.44177965
26	PDK2	1.43184432
27	FGFR2	1.42765242
28	TAOK3	1.39877849
29	WNK4	1.36608110
30	MKNK1	1.32152591
31	BRSK2	1.29309212
32	INSRR	1.28638053
33	MAP2K7	1.27341895
34	ADRBK2	1.25035366
35	MAPK13	1.24609317
36	MARK1	1.24139592
37	DYRK2	1.22445405
38	ACVR1B	1.18518084
39	WEE1	1.14252987
40	STK16	1.14227767
41	OBSCN	1.13776623
42	TSSK6	1.12470502
43	TAF1	1.12013927
44	CSNK1G2	1.07516554
45	PRKCE	1.07005556
46	FER	1.03662789
47	ZAK	1.02934965
48	OXSR1	1.02157429
49	PINK1	1.01896899
50	CLK1	1.00239967
51	CSNK1G1	0.99777754
52	TNIK	0.99152789
53	CSNK1A1L	0.95819344
54	CSNK1G3	0.93528902
55	STK24	0.93468384
56	NEK1	0.89760620
57	BRD4	0.89187538
58	CCNB1	0.86837555
59	PNCK	0.84048896
60	STK3	0.81770525
61	BCR	0.77964456
62	MAPKAPK5	0.76616597
63	VRK2	0.73822623
64	DAPK1	0.72831383
65	MYLK	0.72634905
66	MINK1	0.70111590
67	PLK1	0.66079058
68	NTRK3	0.65135208
69	SIK3	0.63609349
70	PRKCG	0.59578049
71	TEC	0.56251807
72	VRK1	0.54567575
73	FLT3	0.53015458
74	PRKCI	0.48855185
75	BUB1	0.47962896
76	CAMKK2	0.47270770
77	PTK2B	0.46808607
78	PIK3CG	0.45986251
79	AKT3	0.45591193
80	GRK5	0.42901606
81	CAMK2A	0.42289170
82	EIF2AK2	0.40694103
83	CAMK2D	0.38592812
84	MAP2K4	0.37989610
85	ROCK1	0.37746664
86	CDK8	0.36829531
87	PLK4	0.34664954
88	FGFR3	0.32146260
89	CSNK1A1	0.31748129
90	PBK	0.31653227
91	ILK	0.30977126
92	CDK3	0.30781617
93	PRKACA	0.29330530
94	ATM	0.27556187
95	RPS6KA5	0.26576300
96	BCKDK	0.26100727
97	TGFBR1	0.25306511
98	NLK	0.25125582
99	BRSK1	0.24434318
100	ATR	0.22650027

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.76196061
2	Protein export_Homo sapiens_hsa03060	3.68282499
3	Butanoate metabolism_Homo sapiens_hsa00650	2.90838548
4	Proteasome_Homo sapiens_hsa03050	2.76360614
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.64689577
6	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.63853702
7	Propanoate metabolism_Homo sapiens_hsa00640	2.59413275
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.52585377
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.42258612
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.27004869
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.19328552
12	Non-homologous end-joining_Homo sapiens_hsa03450	1.86643618
13	Parkinsons disease_Homo sapiens_hsa05012	1.80717320
14	Homologous recombination_Homo sapiens_hsa03440	1.78133088
15	Sulfur metabolism_Homo sapiens_hsa00920	1.76026528
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.74938479
17	RNA degradation_Homo sapiens_hsa03018	1.74243480
18	Basal transcription factors_Homo sapiens_hsa03022	1.69912052
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.65588729
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.48657944
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.43718133
22	Phototransduction_Homo sapiens_hsa04744	1.37439486
23	Fatty acid elongation_Homo sapiens_hsa00062	1.37017465
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34171908
25	Fatty acid degradation_Homo sapiens_hsa00071	1.33207306
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.32268626
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.31376359
28	beta-Alanine metabolism_Homo sapiens_hsa00410	1.30307961
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.27149365
30	Folate biosynthesis_Homo sapiens_hsa00790	1.22773910
31	RNA polymerase_Homo sapiens_hsa03020	1.19648918
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.18972391
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.15940386
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.14144646
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.13438580
36	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.11149365
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.09809880
38	Peroxisome_Homo sapiens_hsa04146	1.09064310
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.08998260
40	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.07487178
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.03613018
42	Mismatch repair_Homo sapiens_hsa03430	1.02881213
43	Huntingtons disease_Homo sapiens_hsa05016	1.01796038
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.00574091
45	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.00357794
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99670120
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98187997
48	Alzheimers disease_Homo sapiens_hsa05010	0.95599460
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.92450560
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.91947190
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.87192529
52	Caffeine metabolism_Homo sapiens_hsa00232	0.87163550
53	Nicotine addiction_Homo sapiens_hsa05033	0.86941667
54	Purine metabolism_Homo sapiens_hsa00230	0.85460713
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.84862849
56	GABAergic synapse_Homo sapiens_hsa04727	0.84665250
57	Regulation of autophagy_Homo sapiens_hsa04140	0.81209223
58	Metabolic pathways_Homo sapiens_hsa01100	0.80857702
59	Insulin secretion_Homo sapiens_hsa04911	0.80470681
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80090648
61	Glutathione metabolism_Homo sapiens_hsa00480	0.79782980
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77857361
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.77153690
64	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.76579183
65	RNA transport_Homo sapiens_hsa03013	0.74676595
66	ABC transporters_Homo sapiens_hsa02010	0.71561593
67	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.71452066
68	Type I diabetes mellitus_Homo sapiens_hsa04940	0.69620474
69	One carbon pool by folate_Homo sapiens_hsa00670	0.67954936
70	Oocyte meiosis_Homo sapiens_hsa04114	0.65722355
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.64519298
72	Olfactory transduction_Homo sapiens_hsa04740	0.63429076
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.62461120
74	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.62236327
75	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.62178935
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.61721282
77	Circadian rhythm_Homo sapiens_hsa04710	0.60126442
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56703338
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56460196
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55158761
81	Serotonergic synapse_Homo sapiens_hsa04726	0.52029302
82	Taste transduction_Homo sapiens_hsa04742	0.52021384
83	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.49924421
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.48331584
85	Circadian entrainment_Homo sapiens_hsa04713	0.46507405
86	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.44210740
87	Retinol metabolism_Homo sapiens_hsa00830	0.43715175
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43000499
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41360453
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.39996477
91	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.39772070
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.39364896
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.37731940
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36595799
95	Histidine metabolism_Homo sapiens_hsa00340	0.35108215
96	Morphine addiction_Homo sapiens_hsa05032	0.34916324
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34785997
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.33751567
99	Glutamatergic synapse_Homo sapiens_hsa04724	0.33587298
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.31547543

AMD1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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