ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.08555659
2	response to pheromone (GO:0019236)	4.38742715
3	platelet dense granule organization (GO:0060155)	3.91683677
4	DNA deamination (GO:0045006)	3.90699692
5	L-fucose catabolic process (GO:0042355)	3.88911619
6	fucose catabolic process (GO:0019317)	3.88911619
7	L-fucose metabolic process (GO:0042354)	3.88911619
8	indolalkylamine metabolic process (GO:0006586)	3.72009136
9	protein complex biogenesis (GO:0070271)	3.70152058
10	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.65419169
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.65316187
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.65316187
13	NADH dehydrogenase complex assembly (GO:0010257)	3.65316187
14	tryptophan catabolic process (GO:0006569)	3.53774953
15	indole-containing compound catabolic process (GO:0042436)	3.53774953
16	indolalkylamine catabolic process (GO:0046218)	3.53774953
17	mitochondrial respiratory chain complex assembly (GO:0033108)	3.40774813
18	detection of light stimulus involved in visual perception (GO:0050908)	3.39525979
19	detection of light stimulus involved in sensory perception (GO:0050962)	3.39525979
20	tryptophan metabolic process (GO:0006568)	3.37383143
21	respiratory chain complex IV assembly (GO:0008535)	3.35780117
22	piRNA metabolic process (GO:0034587)	3.32165487
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.30606578
24	mannosylation (GO:0097502)	3.23622022
25	kynurenine metabolic process (GO:0070189)	3.22647930
26	protein polyglutamylation (GO:0018095)	3.20323610
27	cellular ketone body metabolic process (GO:0046950)	3.16687829
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.14511564
29	neural tube formation (GO:0001841)	3.13792698
30	dopamine transport (GO:0015872)	3.00312796
31	negative regulation of telomere maintenance (GO:0032205)	3.00236785
32	cytochrome complex assembly (GO:0017004)	2.99795446
33	epithelial cilium movement (GO:0003351)	2.98817548
34	amine catabolic process (GO:0009310)	2.93804782
35	cellular biogenic amine catabolic process (GO:0042402)	2.93804782
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.92348066
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.92348066
38	axoneme assembly (GO:0035082)	2.91783513
39	protein-cofactor linkage (GO:0018065)	2.91404931
40	ketone body metabolic process (GO:1902224)	2.90759259
41	somite development (GO:0061053)	2.87088543
42	preassembly of GPI anchor in ER membrane (GO:0016254)	2.86386498
43	indole-containing compound metabolic process (GO:0042430)	2.84470749
44	regulation of cilium movement (GO:0003352)	2.80270055
45	sulfation (GO:0051923)	2.78551158
46	photoreceptor cell development (GO:0042461)	2.78000922
47	DNA double-strand break processing (GO:0000729)	2.77973795
48	protein localization to cilium (GO:0061512)	2.77709252
49	ubiquinone biosynthetic process (GO:0006744)	2.77700159
50	pyrimidine nucleobase catabolic process (GO:0006208)	2.71556980
51	regulation of hexokinase activity (GO:1903299)	2.71096615
52	regulation of glucokinase activity (GO:0033131)	2.71096615
53	regulation of transmission of nerve impulse (GO:0051969)	2.71080132
54	protein K11-linked deubiquitination (GO:0035871)	2.70596692
55	positive regulation of prostaglandin secretion (GO:0032308)	2.70494210
56	neuronal action potential (GO:0019228)	2.66890208
57	cornea development in camera-type eye (GO:0061303)	2.64591415
58	regulation of mitotic spindle checkpoint (GO:1903504)	2.64407562
59	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.64407562
60	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.63907040
61	nonmotile primary cilium assembly (GO:0035058)	2.62949826
62	negative regulation of mast cell activation (GO:0033004)	2.61674317
63	DNA methylation involved in gamete generation (GO:0043046)	2.61513781
64	ubiquinone metabolic process (GO:0006743)	2.60762710
65	nephron epithelium morphogenesis (GO:0072088)	2.59236913
66	nephron tubule morphogenesis (GO:0072078)	2.59236913
67	multicellular organism reproduction (GO:0032504)	2.58240823
68	synaptic transmission, cholinergic (GO:0007271)	2.57675210
69	positive regulation of fatty acid transport (GO:2000193)	2.57643928
70	rhodopsin mediated signaling pathway (GO:0016056)	2.57557451
71	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.57341923
72	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.57235127
73	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.56682954
74	behavioral response to ethanol (GO:0048149)	2.56239256
75	cilium morphogenesis (GO:0060271)	2.55078811
76	reflex (GO:0060004)	2.52217490
77	recombinational repair (GO:0000725)	2.50772540
78	centriole replication (GO:0007099)	2.50581384
79	GPI anchor metabolic process (GO:0006505)	2.48572622
80	photoreceptor cell maintenance (GO:0045494)	2.48321059
81	eye photoreceptor cell development (GO:0042462)	2.47310191
82	kidney morphogenesis (GO:0060993)	2.46630376
83	adaptation of signaling pathway (GO:0023058)	2.43609035
84	double-strand break repair via homologous recombination (GO:0000724)	2.43389505
85	retina layer formation (GO:0010842)	2.43229644
86	cilium organization (GO:0044782)	2.42605963
87	reciprocal DNA recombination (GO:0035825)	2.42021624
88	reciprocal meiotic recombination (GO:0007131)	2.42021624
89	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.41634062
90	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.40555379
91	regulation of neurotransmitter uptake (GO:0051580)	2.40052738
92	nucleobase catabolic process (GO:0046113)	2.38998017
93	S-adenosylmethionine metabolic process (GO:0046500)	2.38812762
94	retinal cone cell development (GO:0046549)	2.37536142
95	exocrine pancreas development (GO:0031017)	2.36654766
96	neuron fate determination (GO:0048664)	2.35894049
97	cilium assembly (GO:0042384)	2.34795878
98	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.33623985
99	spinal cord motor neuron differentiation (GO:0021522)	2.33262191
100	limb bud formation (GO:0060174)	2.33003825

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.92756415
2	VDR_22108803_ChIP-Seq_LS180_Human	3.34291483
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.08108516
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.75264965
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.70430208
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52119087
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42046538
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.32669433
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.25755634
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.23757443
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.22632750
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15933430
13	FUS_26573619_Chip-Seq_HEK293_Human	2.06443641
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06337991
15	EWS_26573619_Chip-Seq_HEK293_Human	2.05701775
16	P300_19829295_ChIP-Seq_ESCs_Human	1.98820200
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.98217881
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.90399448
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.85252353
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.84861291
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.82002008
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.80658806
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78496161
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.75713991
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74799457
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.71853170
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.63655135
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.63346071
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.62587910
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.58759525
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56378970
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.54524719
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54086088
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.54086088
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50345919
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.49040464
37	AR_25329375_ChIP-Seq_VCAP_Human	1.43773731
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43065800
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43065800
40	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.40502025
41	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37371155
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36762586
43	STAT3_23295773_ChIP-Seq_U87_Human	1.35886268
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35634023
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35533305
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.34791279
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34370248
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33231072
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33231072
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31918842
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31901326
52	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.31410946
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30203905
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30068441
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30068441
56	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29551894
57	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29014733
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28809101
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.28774906
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27959395
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27720693
62	TCF4_23295773_ChIP-Seq_U87_Human	1.27045965
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26798857
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26623130
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25179146
66	AR_21572438_ChIP-Seq_LNCaP_Human	1.25002846
67	ELK1_19687146_ChIP-ChIP_HELA_Human	1.24750028
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24450545
69	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.23817722
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.21738774
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20578191
72	NCOR_22424771_ChIP-Seq_293T_Human	1.20501858
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19906856
74	VDR_23849224_ChIP-Seq_CD4+_Human	1.19654023
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19034627
76	AR_20517297_ChIP-Seq_VCAP_Human	1.15758836
77	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15025344
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14568338
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13482899
80	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13163558
81	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13131008
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12171057
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11816739
84	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10939344
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10119278
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09293833
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08665620
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07338015
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07105453
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05201770
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04582244
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04421003
93	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01630648
94	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00099164
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99914742
96	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99161325
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.97945084
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.96415729
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95227170
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94058000

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.14763778
2	MP0005646_abnormal_pituitary_gland	2.93245955
3	MP0008877_abnormal_DNA_methylation	2.82538323
4	MP0002102_abnormal_ear_morphology	2.58481128
5	MP0003195_calcinosis	2.55416404
6	MP0005551_abnormal_eye_electrophysiolog	2.55379710
7	MP0003136_yellow_coat_color	2.46629628
8	MP0000372_irregular_coat_pigmentation	2.43317477
9	MP0003880_abnormal_central_pattern	2.26646539
10	MP0001968_abnormal_touch/_nociception	2.14586214
11	MP0006292_abnormal_olfactory_placode	2.13007502
12	MP0006072_abnormal_retinal_apoptosis	2.03195707
13	MP0002653_abnormal_ependyma_morphology	1.99244212
14	MP0003787_abnormal_imprinting	1.97407167
15	MP0002876_abnormal_thyroid_physiology	1.97205504
16	MP0002837_dystrophic_cardiac_calcinosis	1.96239180
17	MP0002638_abnormal_pupillary_reflex	1.91226694
18	MP0008875_abnormal_xenobiotic_pharmacok	1.85964183
19	MP0001986_abnormal_taste_sensitivity	1.85408341
20	MP0005084_abnormal_gallbladder_morpholo	1.84187253
21	MP0002736_abnormal_nociception_after	1.82866393
22	MP0008872_abnormal_physiological_respon	1.81940142
23	MP0009745_abnormal_behavioral_response	1.77883754
24	MP0004885_abnormal_endolymph	1.68864375
25	MP0009046_muscle_twitch	1.67331963
26	MP0005253_abnormal_eye_physiology	1.67121698
27	MP0004142_abnormal_muscle_tone	1.66784584
28	MP0001501_abnormal_sleep_pattern	1.62743743
29	MP0002938_white_spotting	1.58431933
30	MP0002272_abnormal_nervous_system	1.57798175
31	MP0005174_abnormal_tail_pigmentation	1.55793591
32	MP0004147_increased_porphyrin_level	1.54961779
33	MP0004043_abnormal_pH_regulation	1.53372631
34	MP0001984_abnormal_olfaction	1.52812917
35	MP0001486_abnormal_startle_reflex	1.49351551
36	MP0006276_abnormal_autonomic_nervous	1.48619309
37	MP0005645_abnormal_hypothalamus_physiol	1.43445370
38	MP0005075_abnormal_melanosome_morpholog	1.40564801
39	MP0000427_abnormal_hair_cycle	1.38184541
40	MP0002735_abnormal_chemical_nociception	1.37304502
41	MP0002138_abnormal_hepatobiliary_system	1.34782151
42	MP0002234_abnormal_pharynx_morphology	1.32197017
43	MP0000631_abnormal_neuroendocrine_gland	1.32084359
44	MP0003011_delayed_dark_adaptation	1.31222806
45	MP0003646_muscle_fatigue	1.30258162
46	MP0004133_heterotaxia	1.28614287
47	MP0001529_abnormal_vocalization	1.28070538
48	MP0005423_abnormal_somatic_nervous	1.26622046
49	MP0005187_abnormal_penis_morphology	1.25852210
50	MP0002928_abnormal_bile_duct	1.21883807
51	MP0002572_abnormal_emotion/affect_behav	1.19300293
52	MP0002095_abnormal_skin_pigmentation	1.15528344
53	MP0005389_reproductive_system_phenotype	1.14315443
54	MP0001970_abnormal_pain_threshold	1.13299674
55	MP0002557_abnormal_social/conspecific_i	1.12546756
56	MP0003718_maternal_effect	1.10864189
57	MP0008995_early_reproductive_senescence	1.10551667
58	MP0001485_abnormal_pinna_reflex	1.09173923
59	MP0002064_seizures	1.09036935
60	MP0002277_abnormal_respiratory_mucosa	1.05115097
61	MP0005195_abnormal_posterior_eye	1.04633532
62	MP0002733_abnormal_thermal_nociception	1.03454790
63	MP0000778_abnormal_nervous_system	1.03314918
64	MP0004742_abnormal_vestibular_system	1.02613934
65	MP0008058_abnormal_DNA_repair	1.01552740
66	MP0002163_abnormal_gland_morphology	1.01119469
67	MP0001905_abnormal_dopamine_level	1.00160198
68	MP0001919_abnormal_reproductive_system	0.98262590
69	MP0001764_abnormal_homeostasis	0.98127619
70	MP0010386_abnormal_urinary_bladder	0.98065476
71	MP0005410_abnormal_fertilization	0.97458996
72	MP0000015_abnormal_ear_pigmentation	0.97347605
73	MP0002160_abnormal_reproductive_system	0.93632939
74	MP0005171_absent_coat_pigmentation	0.89904457
75	MP0001324_abnormal_eye_pigmentation	0.89680884
76	MP0000230_abnormal_systemic_arterial	0.89309075
77	MP0005386_behavior/neurological_phenoty	0.88964873
78	MP0004924_abnormal_behavior	0.88964873
79	MP0002751_abnormal_autonomic_nervous	0.88859668
80	MP0004145_abnormal_muscle_electrophysio	0.88697555
81	MP0000383_abnormal_hair_follicle	0.88194044
82	MP0002067_abnormal_sensory_capabilities	0.88126138
83	MP0003878_abnormal_ear_physiology	0.87777107
84	MP0005377_hearing/vestibular/ear_phenot	0.87777107
85	MP0000026_abnormal_inner_ear	0.87055268
86	MP0005671_abnormal_response_to	0.86970999
87	MP0005379_endocrine/exocrine_gland_phen	0.85052911
88	MP0003121_genomic_imprinting	0.84541045
89	MP0002693_abnormal_pancreas_physiology	0.83215557
90	MP0002752_abnormal_somatic_nervous	0.82310728
91	MP0002184_abnormal_innervation	0.80848097
92	MP0001963_abnormal_hearing_physiology	0.80144835
93	MP0003635_abnormal_synaptic_transmissio	0.80037372
94	MP0002063_abnormal_learning/memory/cond	0.79850492
95	MP0003698_abnormal_male_reproductive	0.79331570
96	MP0001929_abnormal_gametogenesis	0.78368946
97	MP0000613_abnormal_salivary_gland	0.77732607
98	MP0002229_neurodegeneration	0.77533780
99	MP0003283_abnormal_digestive_organ	0.76865802
100	MP0000647_abnormal_sebaceous_gland	0.75936866

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.45237220
2	Congenital stationary night blindness (HP:0007642)	4.33090003
3	True hermaphroditism (HP:0010459)	4.28569472
4	Pancreatic fibrosis (HP:0100732)	4.15920742
5	Abnormality of midbrain morphology (HP:0002418)	3.98166076
6	Molar tooth sign on MRI (HP:0002419)	3.98166076
7	Nephronophthisis (HP:0000090)	3.72744287
8	Type II lissencephaly (HP:0007260)	3.57392758
9	Abnormality of the renal medulla (HP:0100957)	3.25074150
10	Abnormality of the renal cortex (HP:0011035)	3.10957184
11	Medial flaring of the eyebrow (HP:0010747)	3.02001783
12	Attenuation of retinal blood vessels (HP:0007843)	2.92675924
13	Chronic hepatic failure (HP:0100626)	2.82656980
14	Abnormal rod and cone electroretinograms (HP:0008323)	2.82473527
15	Cystic liver disease (HP:0006706)	2.80261919
16	Optic nerve hypoplasia (HP:0000609)	2.69904699
17	Pendular nystagmus (HP:0012043)	2.67872012
18	Hyperventilation (HP:0002883)	2.67125669
19	Abolished electroretinogram (ERG) (HP:0000550)	2.64871755
20	Mitochondrial inheritance (HP:0001427)	2.55533498
21	Sclerocornea (HP:0000647)	2.53375660
22	Renal cortical cysts (HP:0000803)	2.52199792
23	Tubular atrophy (HP:0000092)	2.51953554
24	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.49754951
25	Decreased central vision (HP:0007663)	2.49353971
26	Lissencephaly (HP:0001339)	2.47871100
27	Acute necrotizing encephalopathy (HP:0006965)	2.47522264
28	Increased CSF lactate (HP:0002490)	2.45018718
29	Increased corneal curvature (HP:0100692)	2.44917782
30	Keratoconus (HP:0000563)	2.44917782
31	Stomach cancer (HP:0012126)	2.42963076
32	Polydipsia (HP:0001959)	2.42294804
33	Abnormal drinking behavior (HP:0030082)	2.42294804
34	Absent/shortened dynein arms (HP:0200106)	2.42128916
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.42128916
36	Gait imbalance (HP:0002141)	2.38274882
37	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36691654
38	Congenital primary aphakia (HP:0007707)	2.32281095
39	Cerebellar dysplasia (HP:0007033)	2.29944091
40	Progressive macrocephaly (HP:0004481)	2.25135396
41	Nephrogenic diabetes insipidus (HP:0009806)	2.23909176
42	Hypothermia (HP:0002045)	2.21972674
43	Anencephaly (HP:0002323)	2.20900517
44	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20355547
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.18858323
46	Abnormality of alanine metabolism (HP:0010916)	2.18858323
47	Hyperalaninemia (HP:0003348)	2.18858323
48	Congenital hepatic fibrosis (HP:0002612)	2.17972290
49	Stomatitis (HP:0010280)	2.16480275
50	Large for gestational age (HP:0001520)	2.14179992
51	Abnormality of the labia minora (HP:0012880)	2.13564182
52	Acute encephalopathy (HP:0006846)	2.12742694
53	Male pseudohermaphroditism (HP:0000037)	2.12525480
54	Inability to walk (HP:0002540)	2.11633090
55	3-Methylglutaconic aciduria (HP:0003535)	2.10868788
56	Furrowed tongue (HP:0000221)	2.10512586
57	Lipid accumulation in hepatocytes (HP:0006561)	2.09911646
58	Decreased circulating renin level (HP:0003351)	2.09095992
59	Abnormal mitochondria in muscle tissue (HP:0008316)	2.07858756
60	Abnormality of the pons (HP:0007361)	2.06777405
61	Optic disc pallor (HP:0000543)	2.06278116
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.05441636
63	Pachygyria (HP:0001302)	2.00876599
64	Hepatocellular necrosis (HP:0001404)	2.00171756
65	Broad-based gait (HP:0002136)	1.99554091
66	Abnormality of B cell number (HP:0010975)	1.99266145
67	Abnormal biliary tract physiology (HP:0012439)	1.98934571
68	Bile duct proliferation (HP:0001408)	1.98934571
69	Increased hepatocellular lipid droplets (HP:0006565)	1.98164940
70	Polyuria (HP:0000103)	1.97653943
71	Congenital, generalized hypertrichosis (HP:0004540)	1.96986470
72	Postaxial foot polydactyly (HP:0001830)	1.95484140
73	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.94951695
74	Hypoplasia of the fovea (HP:0007750)	1.94951695
75	Gaze-evoked nystagmus (HP:0000640)	1.94582980
76	Hypoplasia of the pons (HP:0012110)	1.93099864
77	Progressive cerebellar ataxia (HP:0002073)	1.91603368
78	Hepatic necrosis (HP:0002605)	1.91479748
79	Limb dystonia (HP:0002451)	1.89853077
80	Focal motor seizures (HP:0011153)	1.89012046
81	Genital tract atresia (HP:0001827)	1.86355488
82	Retinal dysplasia (HP:0007973)	1.85806629
83	Abnormal respiratory motile cilium morphology (HP:0005938)	1.85686794
84	Abnormal respiratory epithelium morphology (HP:0012253)	1.85686794
85	Methylmalonic acidemia (HP:0002912)	1.84023077
86	Thyroiditis (HP:0100646)	1.83985480
87	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.83790430
88	Postaxial hand polydactyly (HP:0001162)	1.81419506
89	Vaginal atresia (HP:0000148)	1.80974665
90	Concave nail (HP:0001598)	1.79547323
91	Albinism (HP:0001022)	1.79541964
92	Methylmalonic aciduria (HP:0012120)	1.78420537
93	Bilateral microphthalmos (HP:0007633)	1.75776178
94	Chorioretinal atrophy (HP:0000533)	1.73703609
95	Severe visual impairment (HP:0001141)	1.73504483
96	Bony spicule pigmentary retinopathy (HP:0007737)	1.73162642
97	Progressive inability to walk (HP:0002505)	1.72953964
98	IgG deficiency (HP:0004315)	1.71058858
99	Hemiparesis (HP:0001269)	1.69805692
100	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.68776792

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.69416935
2	MAP4K2	3.24245190
3	ADRBK2	3.20989156
4	NUAK1	2.67608433
5	TAOK3	2.61705287
6	WNK3	2.55920139
7	ZAK	2.52292143
8	BMPR1B	2.39439744
9	GRK1	2.22259526
10	CASK	2.07240486
11	PINK1	2.03604081
12	TLK1	2.00402497
13	INSRR	1.99745304
14	MAPK13	1.94326800
15	TXK	1.93381684
16	WNK4	1.86989955
17	TNIK	1.86277840
18	ACVR1B	1.72833766
19	BCKDK	1.56284471
20	MAP3K4	1.40730618
21	PNCK	1.38072890
22	VRK1	1.36069397
23	DYRK2	1.22616930
24	TRIM28	1.22311936
25	OXSR1	1.20737192
26	DAPK2	1.19878988
27	PAK3	1.14097452
28	MARK1	1.13623282
29	MST4	1.10051956
30	ADRBK1	1.05396371
31	MAPK15	1.03733380
32	MKNK2	1.02990065
33	STK39	0.96519120
34	IKBKB	0.96488613
35	EIF2AK3	0.96429958
36	PLK2	0.90644581
37	IRAK1	0.90550900
38	PRKCE	0.90469797
39	NME1	0.88739411
40	VRK2	0.87963025
41	TGFBR1	0.86339120
42	MUSK	0.86332712
43	FGFR2	0.85421616
44	KIT	0.85201168
45	PRKCG	0.85078558
46	CSNK1G2	0.84259793
47	CAMKK2	0.84052372
48	CSNK1G1	0.81575561
49	TEC	0.79371325
50	ERBB3	0.77892020
51	CSNK1G3	0.77815783
52	PLK4	0.77076111
53	PHKG1	0.75153889
54	PHKG2	0.75153889
55	PLK3	0.71927747
56	EPHA4	0.71535874
57	MAP2K7	0.67575905
58	MAPKAPK3	0.67558521
59	WEE1	0.66092722
60	MAP2K2	0.64988076
61	NLK	0.61983708
62	ITK	0.61418790
63	BCR	0.61397654
64	PRKCQ	0.61346094
65	RPS6KA5	0.60343503
66	TIE1	0.57772517
67	PKN1	0.57659650
68	PTK2B	0.57601690
69	CDK8	0.56267239
70	CSNK1A1L	0.55849757
71	NTRK2	0.55393941
72	GRK7	0.54091709
73	NTRK3	0.52618194
74	MKNK1	0.52469943
75	BRSK2	0.51774996
76	MAPKAPK5	0.51560067
77	STK38L	0.50808921
78	IKBKE	0.50397574
79	PRKACA	0.49558034
80	TNK2	0.49097112
81	CAMK2A	0.46718781
82	STK3	0.45578458
83	CCNB1	0.45186375
84	CAMK1	0.44748110
85	PIK3CA	0.43954134
86	CHUK	0.43584412
87	EIF2AK2	0.43541516
88	FLT3	0.43237187
89	CSNK1A1	0.42407813
90	MAP2K6	0.42325142
91	PRKCI	0.40789655
92	MINK1	0.40632966
93	EPHA3	0.40328055
94	STK11	0.39784607
95	SYK	0.38597547
96	LYN	0.37056994
97	BMPR2	0.36605539
98	PDK2	0.36449735
99	PRKCZ	0.35424656
100	PIK3CG	0.34980375

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.89788893
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.52571821
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.43463640
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.37285489
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.34149192
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.30586900
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.24971580
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.24378836
9	Protein export_Homo sapiens_hsa03060	2.22841607
10	Butanoate metabolism_Homo sapiens_hsa00650	2.20681214
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.08647545
12	Parkinsons disease_Homo sapiens_hsa05012	2.04404459
13	Homologous recombination_Homo sapiens_hsa03440	1.97385389
14	RNA polymerase_Homo sapiens_hsa03020	1.96028472
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.84322733
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.77676271
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.76877417
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.70578948
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.69965068
20	Nicotine addiction_Homo sapiens_hsa05033	1.67923385
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.67901513
22	Caffeine metabolism_Homo sapiens_hsa00232	1.65608833
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.65540161
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.63940688
25	Propanoate metabolism_Homo sapiens_hsa00640	1.62839544
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.57804026
27	Proteasome_Homo sapiens_hsa03050	1.54547763
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.53483609
29	Basal transcription factors_Homo sapiens_hsa03022	1.52887236
30	RNA degradation_Homo sapiens_hsa03018	1.33784120
31	Asthma_Homo sapiens_hsa05310	1.30206778
32	Peroxisome_Homo sapiens_hsa04146	1.29795690
33	Huntingtons disease_Homo sapiens_hsa05016	1.26036364
34	Taste transduction_Homo sapiens_hsa04742	1.25268407
35	Alzheimers disease_Homo sapiens_hsa05010	1.24041859
36	Olfactory transduction_Homo sapiens_hsa04740	1.20805647
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.18682374
38	One carbon pool by folate_Homo sapiens_hsa00670	1.18170670
39	Primary immunodeficiency_Homo sapiens_hsa05340	1.17847216
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.13938243
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.11150085
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.10947617
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.10310704
44	Regulation of autophagy_Homo sapiens_hsa04140	1.09762894
45	Morphine addiction_Homo sapiens_hsa05032	1.09671593
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07670635
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.07610307
48	Type I diabetes mellitus_Homo sapiens_hsa04940	1.04743072
49	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.03060584
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00533810
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97028292
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.91443278
53	Retinol metabolism_Homo sapiens_hsa00830	0.87049163
54	Serotonergic synapse_Homo sapiens_hsa04726	0.86736577
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.86002146
56	Allograft rejection_Homo sapiens_hsa05330	0.85817807
57	Purine metabolism_Homo sapiens_hsa00230	0.85400369
58	Sulfur metabolism_Homo sapiens_hsa00920	0.84972598
59	GABAergic synapse_Homo sapiens_hsa04727	0.81028847
60	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.80782077
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80502952
62	Graft-versus-host disease_Homo sapiens_hsa05332	0.79441421
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75028207
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74547624
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.74432368
66	Circadian entrainment_Homo sapiens_hsa04713	0.73971269
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73637389
68	Insulin secretion_Homo sapiens_hsa04911	0.73137089
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69929206
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.68652921
71	ABC transporters_Homo sapiens_hsa02010	0.67169089
72	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.64297784
73	Metabolic pathways_Homo sapiens_hsa01100	0.63410385
74	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62978952
75	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.62258866
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61189173
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59814161
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.58658804
79	Salivary secretion_Homo sapiens_hsa04970	0.58113201
80	Steroid biosynthesis_Homo sapiens_hsa00100	0.57131622
81	Fatty acid elongation_Homo sapiens_hsa00062	0.56664583
82	Rheumatoid arthritis_Homo sapiens_hsa05323	0.55989274
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55695332
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.54770002
85	Glutamatergic synapse_Homo sapiens_hsa04724	0.52669044
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52350199
87	Nucleotide excision repair_Homo sapiens_hsa03420	0.52155073
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52097817
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.51776402
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.48618272
91	Fatty acid degradation_Homo sapiens_hsa00071	0.43925740
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43694425
93	Mineral absorption_Homo sapiens_hsa04978	0.41985148
94	Ribosome_Homo sapiens_hsa03010	0.39239789
95	Dopaminergic synapse_Homo sapiens_hsa04728	0.39052756
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36286760
97	Histidine metabolism_Homo sapiens_hsa00340	0.36024867
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33651018
99	Circadian rhythm_Homo sapiens_hsa04710	0.33424204
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.32725831

AMD1P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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