AMER1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.33788708
2nuclear pore organization (GO:0006999)6.06725155
3DNA strand renaturation (GO:0000733)5.63459792
4pore complex assembly (GO:0046931)5.18753064
5kinetochore assembly (GO:0051382)5.17649826
6presynaptic membrane assembly (GO:0097105)4.97879187
7histone H3-K36 demethylation (GO:0070544)4.77223120
8postsynaptic membrane organization (GO:0001941)4.76239862
9positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.70290001
10kinetochore organization (GO:0051383)4.70188422
11cerebral cortex radially oriented cell migration (GO:0021799)4.49402500
12mitotic sister chromatid cohesion (GO:0007064)4.49366156
13regulation of RNA export from nucleus (GO:0046831)4.41333183
14regulation of NFAT protein import into nucleus (GO:0051532)4.40580994
15DNA unwinding involved in DNA replication (GO:0006268)4.30369845
16positive regulation by host of viral transcription (GO:0043923)4.29291201
17presynaptic membrane organization (GO:0097090)4.13721795
18glucosamine-containing compound catabolic process (GO:1901072)4.09882863
19heterochromatin organization (GO:0070828)4.03601936
20limb bud formation (GO:0060174)3.91839330
21lateral sprouting from an epithelium (GO:0060601)3.86913405
22sympathetic nervous system development (GO:0048485)3.84802762
23regulation of gene silencing by RNA (GO:0060966)3.79198735
24regulation of posttranscriptional gene silencing (GO:0060147)3.79198735
25regulation of gene silencing by miRNA (GO:0060964)3.79198735
26cell proliferation in forebrain (GO:0021846)3.76664581
27mitotic chromosome condensation (GO:0007076)3.75309948
28cranial nerve morphogenesis (GO:0021602)3.71653554
29mRNA stabilization (GO:0048255)3.66593758
30RNA stabilization (GO:0043489)3.66593758
31regulation of translational fidelity (GO:0006450)3.65196522
32regulation of nucleobase-containing compound transport (GO:0032239)3.64738568
33DNA duplex unwinding (GO:0032508)3.62369362
34regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.54914627
35head development (GO:0060322)3.54231541
36negative regulation of DNA repair (GO:0045738)3.51953351
37negative regulation of homotypic cell-cell adhesion (GO:0034111)3.51138688
38paraxial mesoderm development (GO:0048339)3.50888967
39mRNA splice site selection (GO:0006376)3.50055061
40positive regulation of histone deacetylation (GO:0031065)3.49786226
41facial nerve structural organization (GO:0021612)3.48251007
42DNA geometric change (GO:0032392)3.45279059
43mesenchymal-epithelial cell signaling (GO:0060638)3.44384744
44kidney morphogenesis (GO:0060993)3.43949968
45negative regulation of histone methylation (GO:0031061)3.42714147
46response to UV-C (GO:0010225)3.32904383
47cellular protein complex localization (GO:0034629)3.31208021
48central nervous system projection neuron axonogenesis (GO:0021952)3.29860950
49histone H3-K4 trimethylation (GO:0080182)3.29139034
50germinal center formation (GO:0002467)3.23737198
51cytoplasmic mRNA processing body assembly (GO:0033962)3.23168772
52regulation of stem cell maintenance (GO:2000036)3.23162072
53pyrimidine nucleobase catabolic process (GO:0006208)3.22140041
54neuron cell-cell adhesion (GO:0007158)3.21546497
55microtubule depolymerization (GO:0007019)3.18701007
56DNA replication initiation (GO:0006270)3.18601905
57spliceosomal tri-snRNP complex assembly (GO:0000244)3.17433839
58embryonic forelimb morphogenesis (GO:0035115)3.16195864
59negative regulation of histone modification (GO:0031057)3.15316781
60protein complex localization (GO:0031503)3.12265454
61protein-DNA complex disassembly (GO:0032986)3.09511244
62nucleosome disassembly (GO:0006337)3.09511244
63negative regulation of histone acetylation (GO:0035067)3.09102788
64* mesenchymal cell differentiation involved in renal system development (GO:2001012)3.09002443
65* mesenchymal cell differentiation involved in kidney development (GO:0072161)3.09002443
66cranial nerve structural organization (GO:0021604)3.08600216
67chromatin assembly (GO:0031497)3.02917672
68protein export from nucleus (GO:0006611)3.02136642
69negative regulation of cell size (GO:0045792)2.99747162
70peptidyl-lysine dimethylation (GO:0018027)2.98972653
71replication fork processing (GO:0031297)2.97947976
72DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.97732309
73forelimb morphogenesis (GO:0035136)2.97290974
74generation of neurons (GO:0048699)2.95201714
75mitotic nuclear envelope disassembly (GO:0007077)2.94972444
76negative regulation of peptidyl-lysine acetylation (GO:2000757)2.93127036
77retina layer formation (GO:0010842)2.91840901
78DNA topological change (GO:0006265)2.91812813
79planar cell polarity pathway involved in neural tube closure (GO:0090179)2.88627589
80cerebral cortex cell migration (GO:0021795)2.88252380
81nuclear envelope disassembly (GO:0051081)2.87965453
82membrane disassembly (GO:0030397)2.87965453
83branching involved in labyrinthine layer morphogenesis (GO:0060670)2.87514142
84cell-substrate adherens junction assembly (GO:0007045)2.87331828
85focal adhesion assembly (GO:0048041)2.87331828
86cell migration in hindbrain (GO:0021535)2.87199312
873-UTR-mediated mRNA stabilization (GO:0070935)2.87137781
88vocalization behavior (GO:0071625)2.86635622
89DNA conformation change (GO:0071103)2.86538239
90negative regulation of chromatin modification (GO:1903309)2.86221964
91positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.85715106
92sister chromatid segregation (GO:0000819)2.83275245
93cardiac ventricle formation (GO:0003211)2.82955689
94embryonic process involved in female pregnancy (GO:0060136)2.82498909
95regulation of DNA damage checkpoint (GO:2000001)2.80508276
96cardiac chamber formation (GO:0003207)2.80505965
97adherens junction assembly (GO:0034333)2.79661287
98rRNA catabolic process (GO:0016075)2.79025498
99regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.78907378
100mesonephros development (GO:0001823)2.78822145
101anatomical structure arrangement (GO:0048532)2.78800179
102regulation of hippo signaling (GO:0035330)2.78505718
103specification of organ identity (GO:0010092)2.78458177
104response to redox state (GO:0051775)2.78342942
105chromatin silencing (GO:0006342)2.77399148
106metanephric mesenchyme development (GO:0072075)2.77228407
107protein localization to chromosome, centromeric region (GO:0071459)2.76044591
108mature B cell differentiation involved in immune response (GO:0002313)2.75815544
109* cell differentiation involved in kidney development (GO:0061005)2.75623061
110regulation of mRNA stability (GO:0043488)2.74285334
111DNA damage response, signal transduction resulting in transcription (GO:0042772)2.74103732
112positive regulation of protein deacetylation (GO:0090312)2.72803724
113female gonad development (GO:0008585)2.72235780
114snRNA transcription (GO:0009301)2.71796772
115negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71578920
116regulation of non-canonical Wnt signaling pathway (GO:2000050)2.71338074
117regulation of histone deacetylation (GO:0031063)2.69976529
118establishment of mitotic spindle orientation (GO:0000132)2.68964677
119central nervous system neuron axonogenesis (GO:0021955)2.68919784
120cartilage morphogenesis (GO:0060536)2.68705212
121righting reflex (GO:0060013)2.66980885
122positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.66410223
123kidney mesenchyme development (GO:0072074)2.66041323
124regulation of DNA endoreduplication (GO:0032875)2.65616668
125regulation of histone H3-K9 methylation (GO:0051570)2.64078778
126cell differentiation involved in metanephros development (GO:0072202)2.63989180
127* mesenchymal cell differentiation (GO:0048762)2.62944247
128negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.62384423
129glucocorticoid receptor signaling pathway (GO:0042921)2.62383888
130interkinetic nuclear migration (GO:0022027)2.60442491
131proximal/distal pattern formation (GO:0009954)2.60245955
132NLS-bearing protein import into nucleus (GO:0006607)2.60152076
133post-anal tail morphogenesis (GO:0036342)2.59935043
134replicative senescence (GO:0090399)2.59827061
135positive regulation of neuroblast proliferation (GO:0002052)2.59290186
136cornea development in camera-type eye (GO:0061303)2.58842332
137regulation of mammary gland epithelial cell proliferation (GO:0033599)2.58064713
138negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.57072061
139neuron recognition (GO:0008038)2.56975194
140histone lysine demethylation (GO:0070076)2.55828872
141regulation of synapse maturation (GO:0090128)2.55651224
142regulation of glucose import in response to insulin stimulus (GO:2001273)2.54998089
143negative regulation of keratinocyte proliferation (GO:0010839)2.54412357
144negative regulation of gene expression, epigenetic (GO:0045814)2.54327651
145dendritic spine morphogenesis (GO:0060997)2.53626729
146regulation of chromatin binding (GO:0035561)2.53437473
147olfactory bulb development (GO:0021772)2.52811837
148regulation of histone H3-K27 methylation (GO:0061085)2.52685383
149regulation of pigment cell differentiation (GO:0050932)2.52418873
150positive regulation of protein homodimerization activity (GO:0090073)2.52306899
151mitotic sister chromatid segregation (GO:0000070)2.51819357
152positive regulation of vascular permeability (GO:0043117)2.50254037
153DNA strand elongation involved in DNA replication (GO:0006271)2.50228803
154regulation of protein deacetylation (GO:0090311)2.49802436
155atrial septum morphogenesis (GO:0060413)2.49777352
156regulation of RNA stability (GO:0043487)2.49754521
157histone phosphorylation (GO:0016572)2.49676395
158regulation of ruffle assembly (GO:1900027)2.49156893
159regulation of mitochondrial translation (GO:0070129)2.47837333
160L-alpha-amino acid transmembrane transport (GO:1902475)2.47453653
161regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.46947275
162axonal fasciculation (GO:0007413)2.46444890
163cGMP-mediated signaling (GO:0019934)2.45916310
164pathway-restricted SMAD protein phosphorylation (GO:0060389)2.45645875
165establishment of mitotic spindle localization (GO:0040001)2.43627195
166trophectodermal cell differentiation (GO:0001829)2.43597100
167cardiac right ventricle morphogenesis (GO:0003215)2.43363676
168pre-miRNA processing (GO:0031054)2.42704553
169DNA strand elongation (GO:0022616)2.42570806
170maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.41516097
171artery development (GO:0060840)2.41140352
172hippo signaling (GO:0035329)2.40706825
173notochord development (GO:0030903)2.40576814
174mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.39861070
175modulation by host of symbiont transcription (GO:0052472)2.39781635
176modulation by host of viral transcription (GO:0043921)2.39781635
177mRNA transport (GO:0051028)2.39759280
178regulation of cAMP-dependent protein kinase activity (GO:2000479)2.39143939
179embryonic limb morphogenesis (GO:0030326)2.38344665
180embryonic appendage morphogenesis (GO:0035113)2.38344665
181developmental induction (GO:0031128)2.37902397
182appendage morphogenesis (GO:0035107)2.37384901
183limb morphogenesis (GO:0035108)2.37384901
184determination of adult lifespan (GO:0008340)2.37195515
185regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.35717502
186hindlimb morphogenesis (GO:0035137)2.34897815
187definitive hemopoiesis (GO:0060216)2.33318898
188cell-cell signaling involved in cell fate commitment (GO:0045168)2.32521663
189regulation of synapse assembly (GO:0051963)2.32399178
190regulation of timing of cell differentiation (GO:0048505)2.31579831
191regulation of development, heterochronic (GO:0040034)2.31024248
192positive regulation of cardiac muscle cell differentiation (GO:2000727)2.30250207
193establishment of spindle orientation (GO:0051294)2.29914705
194regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.29089301
195anterior/posterior pattern specification (GO:0009952)2.28536920
196regulation of helicase activity (GO:0051095)2.27318334
197nucleobase catabolic process (GO:0046113)2.25586562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.39545849
2EZH2_22144423_ChIP-Seq_EOC_Human5.01070880
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.86699578
4MYC_22102868_ChIP-Seq_BL_Human4.60777435
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.38964577
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.33338152
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.20526544
8GBX2_23144817_ChIP-Seq_PC3_Human3.08002102
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.00415946
10TAF15_26573619_Chip-Seq_HEK293_Human2.78674335
11E2F7_22180533_ChIP-Seq_HELA_Human2.75625697
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.61814522
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.60961550
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.53561307
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.44616145
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44560504
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.44455565
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.43025342
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.41995341
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41736722
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.41258869
22AR_21909140_ChIP-Seq_LNCAP_Human2.38140961
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.35328848
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.29951599
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.24600157
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.22973477
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.19449245
28VDR_21846776_ChIP-Seq_THP-1_Human2.19082669
29FUS_26573619_Chip-Seq_HEK293_Human2.16424044
30IGF1R_20145208_ChIP-Seq_DFB_Human2.10735037
31POU5F1_16153702_ChIP-ChIP_HESCs_Human2.09145580
32TCF7_22412390_ChIP-Seq_EML_Mouse2.01838675
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01640587
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01205966
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01001919
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00889827
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99777281
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99777281
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.99199308
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.98901447
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.98888873
42RNF2_27304074_Chip-Seq_NSC_Mouse1.98253276
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96731768
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.95307426
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.92279465
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92067443
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90423985
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89499079
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89499079
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.89458087
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89134711
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.84848393
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.83667064
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83096071
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.82645970
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82634039
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82098375
58EWS_26573619_Chip-Seq_HEK293_Human1.76634015
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72415503
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71836779
61P300_19829295_ChIP-Seq_ESCs_Human1.70646277
62KDM2B_26808549_Chip-Seq_DND41_Human1.70369142
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69807678
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.68965904
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.68669368
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67865391
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65319594
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62856963
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.61749104
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.60993229
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59351620
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.55901023
73ZNF263_19887448_ChIP-Seq_K562_Human1.54674983
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53230871
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51870145
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51848459
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51417275
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50935416
79AR_21572438_ChIP-Seq_LNCaP_Human1.49046301
80KDM2B_26808549_Chip-Seq_K562_Human1.48386735
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.48252222
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46380870
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46077521
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43211391
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43130043
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42603835
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39695095
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38748741
89TP53_18474530_ChIP-ChIP_U2OS_Human1.38262958
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37404706
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.37321823
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37162431
93NANOG_21062744_ChIP-ChIP_HESCs_Human1.36223273
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35788473
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.34805330
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34049157
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33869078
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.33584038
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.33224501
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32510590
101ZNF274_21170338_ChIP-Seq_K562_Hela1.32206971
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28881158
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28580162
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.28429991
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27654923
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27545757
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.26559421
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26389739
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.25720196
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24969315
111CHD1_26751641_Chip-Seq_LNCaP_Human1.24739286
112SMAD4_21799915_ChIP-Seq_A2780_Human1.23372644
113FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22923968
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22519550
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21882806
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21446984
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21444605
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21436721
119VDR_22108803_ChIP-Seq_LS180_Human1.21387367
120CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21044823
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20427182
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20313558
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20095304
124AR_25329375_ChIP-Seq_VCAP_Human1.19629778
125TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19072474
126ISL1_27105846_Chip-Seq_CPCs_Mouse1.18284442
127SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18129331
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15143843
129LXR_22292898_ChIP-Seq_THP-1_Human1.14646935
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14204017
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13947602
132RACK7_27058665_Chip-Seq_MCF-7_Human1.13522318
133MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13097182
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12930444
135E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12768181
136STAT3_23295773_ChIP-Seq_U87_Human1.11747317
137P53_22387025_ChIP-Seq_ESCs_Mouse1.10540008
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09381019
139SOX9_26525672_Chip-Seq_HEART_Mouse1.09184310
140ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09183066
141PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09158450
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08975015
143STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08885089
144KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08617305
145KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08617305
146KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08617305
147POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08594528
148RUNX1_27514584_Chip-Seq_MCF-7_Human1.08134182
149EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08087571
150CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07758334
151CMYC_18555785_Chip-Seq_ESCs_Mouse1.07380743
152ARNT_22903824_ChIP-Seq_MCF-7_Human1.07318873
153TCF4_18268006_ChIP-ChIP_LS174T_Human1.06911904
154PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06810319
155KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06486679
156SOX2_16153702_ChIP-ChIP_HESCs_Human1.06221358
157NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05053925
158KDM5A_27292631_Chip-Seq_BREAST_Human1.04532869
159SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03877467
160SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03718541
161CREB1_26743006_Chip-Seq_LNCaP_Human1.03639620
162EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03635358
163TCF4_23295773_ChIP-Seq_U87_Human1.03497044
164JUN_21703547_ChIP-Seq_K562_Human1.03077613
165CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02895410
166TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02054322
167EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02032012
168NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01887900
169ESR1_20079471_ChIP-ChIP_T-47D_Human1.01832392
170AHR_22903824_ChIP-Seq_MCF-7_Human1.00998899
171SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00804982
172TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00580922
173FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99937985
174POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99800710
175VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98739340
176NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98339062
177POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96731555
178CLOCK_20551151_ChIP-Seq_293T_Human0.94963783
179XRN2_22483619_ChIP-Seq_HELA_Human0.94538540
180RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94293085
181MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92520190
182MAF_26560356_Chip-Seq_TH1_Human0.90293893
183ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90222520
184SMC4_20622854_ChIP-Seq_HELA_Human0.89892239
185GATA1_22025678_ChIP-Seq_K562_Human0.88724189
186MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87562756
187HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85765419
188CIITA_25753668_ChIP-Seq_RAJI_Human0.85412276
189ATF3_27146783_Chip-Seq_COLON_Human0.85338873
190NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85106240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation3.61277705
2MP0006292_abnormal_olfactory_placode3.43792577
3MP0001986_abnormal_taste_sensitivity3.42834020
4MP0002102_abnormal_ear_morphology3.39986527
5MP0003890_abnormal_embryonic-extraembry3.39433563
6MP0005423_abnormal_somatic_nervous3.11347114
7MP0004233_abnormal_muscle_weight3.07406017
8MP0003787_abnormal_imprinting2.97183220
9MP0003693_abnormal_embryo_hatching2.89810529
10MP0003705_abnormal_hypodermis_morpholog2.89362264
11MP0001188_hyperpigmentation2.75069834
12MP0003121_genomic_imprinting2.53617037
13MP0005076_abnormal_cell_differentiation2.46994051
14MP0002009_preneoplasia2.42135197
15MP0003646_muscle_fatigue2.40537728
16MP0002938_white_spotting2.37518811
17MP0009672_abnormal_birth_weight2.34307035
18MP0002249_abnormal_larynx_morphology2.28788441
19MP0003937_abnormal_limbs/digits/tail_de2.26031545
20MP0003122_maternal_imprinting2.21693525
21MP0000733_abnormal_muscle_development2.17846879
22MP0005409_darkened_coat_color2.14143824
23MP0000049_abnormal_middle_ear2.12980533
24MP0004957_abnormal_blastocyst_morpholog2.12335581
25MP0004133_heterotaxia2.10221822
26MP0004084_abnormal_cardiac_muscle2.09111383
27MP0003385_abnormal_body_wall2.08386947
28MP0000778_abnormal_nervous_system2.05103250
29MP0003938_abnormal_ear_development2.00820378
30MP0004185_abnormal_adipocyte_glucose1.96248513
31MP0003941_abnormal_skin_development1.94789070
32MP0009250_abnormal_appendicular_skeleto1.93690244
33MP0001730_embryonic_growth_arrest1.89791494
34MP0009379_abnormal_foot_pigmentation1.87819673
35MP0001661_extended_life_span1.85340180
36MP0003077_abnormal_cell_cycle1.83046188
37MP0000566_synostosis1.81062091
38MP0001672_abnormal_embryogenesis/_devel1.80715672
39MP0005380_embryogenesis_phenotype1.80715672
40MP0010352_gastrointestinal_tract_polyps1.74648494
41MP0003984_embryonic_growth_retardation1.71554743
42MP0003315_abnormal_perineum_morphology1.69278295
43MP0003183_abnormal_peptide_metabolism1.65870140
44MP0002088_abnormal_embryonic_growth/wei1.63808919
45MP0000631_abnormal_neuroendocrine_gland1.62296717
46MP0005451_abnormal_body_composition1.61784881
47MP0002084_abnormal_developmental_patter1.60023987
48MP0004197_abnormal_fetal_growth/weight/1.58472059
49MP0002751_abnormal_autonomic_nervous1.56767268
50MP0002089_abnormal_postnatal_growth/wei1.50580174
51MP0000350_abnormal_cell_proliferation1.50268428
52MP0009703_decreased_birth_body1.48461126
53MP0001697_abnormal_embryo_size1.46950530
54MP0004036_abnormal_muscle_relaxation1.45665707
55MP0010307_abnormal_tumor_latency1.45520742
56MP0002086_abnormal_extraembryonic_tissu1.45255061
57MP0002177_abnormal_outer_ear1.44743436
58MP0002184_abnormal_innervation1.40669471
59MP0005394_taste/olfaction_phenotype1.39805921
60MP0005499_abnormal_olfactory_system1.39805921
61MP0003115_abnormal_respiratory_system1.39111955
62MP0004858_abnormal_nervous_system1.37856667
63MP0003935_abnormal_craniofacial_develop1.33730252
64MP0002080_prenatal_lethality1.33495600
65MP0003755_abnormal_palate_morphology1.33059611
66MP0003136_yellow_coat_color1.32410113
67MP0000751_myopathy1.30689463
68MP0005623_abnormal_meninges_morphology1.29517321
69MP0000537_abnormal_urethra_morphology1.28444188
70MP0002233_abnormal_nose_morphology1.27997832
71MP0003942_abnormal_urinary_system1.27906009
72MP0010630_abnormal_cardiac_muscle1.27365021
73MP0008789_abnormal_olfactory_epithelium1.26644166
74MP0002638_abnormal_pupillary_reflex1.26240344
75MP0001486_abnormal_startle_reflex1.25837059
76MP0000579_abnormal_nail_morphology1.25569114
77MP0002116_abnormal_craniofacial_bone1.24587887
78MP0000750_abnormal_muscle_regeneration1.23965486
79MP0006276_abnormal_autonomic_nervous1.23795869
80MP0001348_abnormal_lacrimal_gland1.23463201
81MP0004808_abnormal_hematopoietic_stem1.22795496
82MP0008995_early_reproductive_senescence1.22550908
83MP0003111_abnormal_nucleus_morphology1.21397009
84MP0000759_abnormal_skeletal_muscle1.21356244
85MP0004087_abnormal_muscle_fiber1.21344411
86MP0000747_muscle_weakness1.21227318
87MP0000432_abnormal_head_morphology1.20416787
88MP0003861_abnormal_nervous_system1.19454563
89MP0003567_abnormal_fetal_cardiomyocyte1.18082826
90MP0008058_abnormal_DNA_repair1.14998209
91MP0005220_abnormal_exocrine_pancreas1.14780131
92MP0010030_abnormal_orbit_morphology1.14563768
93MP0002114_abnormal_axial_skeleton1.11100164
94MP0002109_abnormal_limb_morphology1.09919301
95MP0009053_abnormal_anal_canal1.09588103
96MP0002269_muscular_atrophy1.08024106
97MP0002092_abnormal_eye_morphology1.07182897
98MP0000534_abnormal_ureter_morphology1.07085290
99MP0004264_abnormal_extraembryonic_tissu1.06451541
100MP0003566_abnormal_cell_adhesion1.06224845
101MP0010094_abnormal_chromosome_stability1.03510763
102MP0003123_paternal_imprinting1.02953756
103MP0000762_abnormal_tongue_morphology1.02524542
104MP0000026_abnormal_inner_ear1.01461450
105MP0002160_abnormal_reproductive_system1.00862187
106MP0002932_abnormal_joint_morphology1.00337682
107MP0006072_abnormal_retinal_apoptosis1.00138663
108MP0002557_abnormal_social/conspecific_i0.99401743
109MP0001440_abnormal_grooming_behavior0.99156941
110MP0002697_abnormal_eye_size0.98727981
111MP0001873_stomach_inflammation0.97555764
112MP0001299_abnormal_eye_distance/0.97344505
113MP0002106_abnormal_muscle_physiology0.97208270
114MP0002277_abnormal_respiratory_mucosa0.96766454
115MP0000681_abnormal_thyroid_gland0.96024643
116MP0003119_abnormal_digestive_system0.95533807
117MP0001849_ear_inflammation0.95528908
118MP0002081_perinatal_lethality0.95270740
119MP0005645_abnormal_hypothalamus_physiol0.95268905
120MP0000749_muscle_degeneration0.93406236
121MP0000003_abnormal_adipose_tissue0.93120608
122MP0001984_abnormal_olfaction0.92761660
123MP0001501_abnormal_sleep_pattern0.92370350
124MP0002067_abnormal_sensory_capabilities0.91220655
125MP0004130_abnormal_muscle_cell0.88609344
126MP0008057_abnormal_DNA_replication0.87613407
127MP0004145_abnormal_muscle_electrophysio0.87437766
128MP0001286_abnormal_eye_development0.87264795
129MP0009384_cardiac_valve_regurgitation0.86140381
130MP0002925_abnormal_cardiovascular_devel0.86006467
131MP0001915_intracranial_hemorrhage0.85469306
132MP0001919_abnormal_reproductive_system0.84709755
133MP0002752_abnormal_somatic_nervous0.84689266
134MP0005666_abnormal_adipose_tissue0.84551314
135MP0005248_abnormal_Harderian_gland0.84388916
136MP0001293_anophthalmia0.84129655
137MP0006138_congestive_heart_failure0.83647162
138MP0004742_abnormal_vestibular_system0.83216284
139MP0008877_abnormal_DNA_methylation0.83058182
140MP0005389_reproductive_system_phenotype0.82664852
141MP0002063_abnormal_learning/memory/cond0.80535968
142MP0002734_abnormal_mechanical_nocicepti0.79823931
143MP0001529_abnormal_vocalization0.78491738
144MP0005369_muscle_phenotype0.78154018
145MP0002152_abnormal_brain_morphology0.77435356
146MP0005375_adipose_tissue_phenotype0.76569705
147MP0001340_abnormal_eyelid_morphology0.76316306
148MP0002572_abnormal_emotion/affect_behav0.76182889
149MP0002108_abnormal_muscle_morphology0.76177012
150MP0002396_abnormal_hematopoietic_system0.75680211
151MP0004134_abnormal_chest_morphology0.75265833
152MP0010386_abnormal_urinary_bladder0.74468629
153MP0002282_abnormal_trachea_morphology0.73427417
154MP0000428_abnormal_craniofacial_morphol0.73421812
155MP0000516_abnormal_urinary_system0.73266652
156MP0005367_renal/urinary_system_phenotyp0.73266652
157MP0000266_abnormal_heart_morphology0.72085065
158MP0003828_pulmonary_edema0.72057795
159MP0002735_abnormal_chemical_nociception0.71590818
160MP0000462_abnormal_digestive_system0.70513611
161MP0005257_abnormal_intraocular_pressure0.69520626
162MP0002876_abnormal_thyroid_physiology0.68618309
163MP0005174_abnormal_tail_pigmentation0.68360932
164MP0008932_abnormal_embryonic_tissue0.67947237
165MP0002095_abnormal_skin_pigmentation0.67325612
166MP0002085_abnormal_embryonic_tissue0.67174721
167MP0004270_analgesia0.64860729
168MP0002111_abnormal_tail_morphology0.64074783
169MP0002127_abnormal_cardiovascular_syste0.63884528

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.70668258
2Chromsome breakage (HP:0040012)5.15281196
3Unilateral renal agenesis (HP:0000122)4.40018196
4Thyroid-stimulating hormone excess (HP:0002925)4.23395099
5Nephroblastoma (Wilms tumor) (HP:0002667)4.21566206
6Embryonal renal neoplasm (HP:0011794)4.10490462
7Medulloblastoma (HP:0002885)3.64057810
8Bilateral microphthalmos (HP:0007633)3.62781050
9Aplastic anemia (HP:0001915)3.49856415
10Short tibia (HP:0005736)3.41867171
11Dysmetric saccades (HP:0000641)3.41647473
12Aplasia/Hypoplasia of the tibia (HP:0005772)3.38761020
13Hyperacusis (HP:0010780)3.17178365
14Abnormality of the fingertips (HP:0001211)2.99687756
15Septo-optic dysplasia (HP:0100842)2.97213855
16Embryonal neoplasm (HP:0002898)2.93364591
17Aplasia involving bones of the upper limbs (HP:0009823)2.91846026
18Aplasia of the phalanges of the hand (HP:0009802)2.91846026
19Aplasia involving bones of the extremities (HP:0009825)2.91846026
20* Fibular aplasia (HP:0002990)2.74879053
21Capillary hemangiomas (HP:0005306)2.70131674
22Cutaneous finger syndactyly (HP:0010554)2.68842374
23Meckel diverticulum (HP:0002245)2.65972814
24Aplasia cutis congenita (HP:0001057)2.61398265
25Abnormality of chromosome stability (HP:0003220)2.59947432
26Duplication of thumb phalanx (HP:0009942)2.57032378
27Abnormality of the ileum (HP:0001549)2.52562738
28Supernumerary spleens (HP:0009799)2.47924910
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.47113256
30Tubulointerstitial nephritis (HP:0001970)2.40202258
31Birth length less than 3rd percentile (HP:0003561)2.38907969
32Cutaneous syndactyly (HP:0012725)2.38537587
33Sparse lateral eyebrow (HP:0005338)2.38436839
34Fused cervical vertebrae (HP:0002949)2.37551121
35Aortic aneurysm (HP:0004942)2.36086855
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.35768025
37Short 4th metacarpal (HP:0010044)2.35768025
38Abnormal lung lobation (HP:0002101)2.34448865
39Abnormality of the preputium (HP:0100587)2.30795801
40Chin dimple (HP:0010751)2.28087434
41Subacute progressive viral hepatitis (HP:0006572)2.26364873
42Abnormality of the septum pellucidum (HP:0007375)2.25650639
43Abnormality of the phalanges of the hallux (HP:0010057)2.25506588
44Abnormality of the calcaneus (HP:0008364)2.25404458
45Morphological abnormality of the middle ear (HP:0008609)2.24314844
46Lip pit (HP:0100267)2.22897547
47Hepatoblastoma (HP:0002884)2.22508374
48Midline defect of the nose (HP:0004122)2.19489656
49Long eyelashes (HP:0000527)2.17688787
50Anomalous pulmonary venous return (HP:0010772)2.16813447
51Vertebral arch anomaly (HP:0008438)2.16049136
52Absent septum pellucidum (HP:0001331)2.15990272
53Increased nuchal translucency (HP:0010880)2.15485871
54Leiomyosarcoma (HP:0100243)2.15018274
55Uterine leiomyosarcoma (HP:0002891)2.15018274
56Abnormality of the parietal bone (HP:0002696)2.14933369
57Protruding tongue (HP:0010808)2.14223611
58High anterior hairline (HP:0009890)2.13842038
59Supernumerary ribs (HP:0005815)2.13455745
60Gastrointestinal carcinoma (HP:0002672)2.12976367
61Malignant gastrointestinal tract tumors (HP:0006749)2.12976367
62Renovascular hypertension (HP:0100817)2.12280388
63Abnormal number of incisors (HP:0011064)2.10696457
64Duodenal stenosis (HP:0100867)2.09882179
65Small intestinal stenosis (HP:0012848)2.09882179
66Osteomalacia (HP:0002749)2.09040540
67Abnormality of the pulmonary veins (HP:0011718)2.08818960
68Flat acetabular roof (HP:0003180)2.07859444
69Wrist flexion contracture (HP:0001239)2.06998659
70Diastasis recti (HP:0001540)2.06964746
71Colon cancer (HP:0003003)2.04123209
72Germ cell neoplasia (HP:0100728)2.04068308
73Ependymoma (HP:0002888)2.03724598
74Abnormality of the distal phalanx of the thumb (HP:0009617)2.02952719
75Facial cleft (HP:0002006)2.02517676
76* Anal stenosis (HP:0002025)2.02423557
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02403620
78Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.01119402
79Abnormality of the renal collecting system (HP:0004742)2.01062167
80Triphalangeal thumb (HP:0001199)2.00375572
81Selective tooth agenesis (HP:0001592)2.00321439
82Abnormality of the incisor (HP:0000676)2.00190180
83Heterotopia (HP:0002282)1.98740465
84* Aplasia/Hypoplasia of the fibula (HP:0006492)1.98513809
85Abnormality of the nasolacrimal system (HP:0000614)1.98404589
86Long palpebral fissure (HP:0000637)1.95583560
87Calcaneovalgus deformity (HP:0001848)1.94745078
88Neonatal hypoglycemia (HP:0001998)1.93825470
89Supernumerary bones of the axial skeleton (HP:0009144)1.93468567
90Mixed hearing impairment (HP:0000410)1.92951480
91Clubbing of toes (HP:0100760)1.92821660
92Abnormality of the lacrimal duct (HP:0011481)1.92788236
93Obsessive-compulsive behavior (HP:0000722)1.92589501
94Short thumb (HP:0009778)1.91773728
95Skull defect (HP:0001362)1.91612739
96Increased number of teeth (HP:0011069)1.90775490
97Renal duplication (HP:0000075)1.87898871
98Ankyloglossia (HP:0010296)1.87894770
99Overriding aorta (HP:0002623)1.87757262
100Facial hemangioma (HP:0000329)1.87311334
101Nasolacrimal duct obstruction (HP:0000579)1.87291539
102Trigonocephaly (HP:0000243)1.86960434
103Prominent occiput (HP:0000269)1.86625322
104Disproportionate tall stature (HP:0001519)1.85717314
105Preauricular pit (HP:0004467)1.85487536
106Periauricular skin pits (HP:0100277)1.85487536
107Duplicated collecting system (HP:0000081)1.85480776
108Renal cell carcinoma (HP:0005584)1.85410776
109Elfin facies (HP:0004428)1.84824928
110Nemaline bodies (HP:0003798)1.84656827
111Progressive muscle weakness (HP:0003323)1.82349974
112Broad thumb (HP:0011304)1.80614345
113* Asymmetry of the thorax (HP:0001555)1.80020543
114Atresia of the external auditory canal (HP:0000413)1.80010014
115Hemangiomatosis (HP:0007461)1.79730232
116Sandal gap (HP:0001852)1.78938526
117Ectopic anus (HP:0004397)1.78897429
118Double outlet right ventricle (HP:0001719)1.78795062
119Congenital malformation of the right heart (HP:0011723)1.78795062
120Preaxial foot polydactyly (HP:0001841)1.78238649
121* Abnormality of the thoracic spine (HP:0100711)1.78148524
122Abnormality of DNA repair (HP:0003254)1.78097593
123Abnormality of chromosome segregation (HP:0002916)1.77468273
124Deviation of the thumb (HP:0009603)1.76973128
125Abnormality of the left ventricular outflow tract (HP:0011103)1.76940123
126Subaortic stenosis (HP:0001682)1.76940123
127Choanal stenosis (HP:0000452)1.75266624
128Myelodysplasia (HP:0002863)1.74962292
129Absent eyelashes (HP:0000561)1.74455263
130Muscle fiber inclusion bodies (HP:0100299)1.74261199
131Transitional cell carcinoma of the bladder (HP:0006740)1.74018541
132Exotropia (HP:0000577)1.73614977
133Macroorchidism (HP:0000053)1.73422819
134Preaxial hand polydactyly (HP:0001177)1.72811366
135Multiple enchondromatosis (HP:0005701)1.72524609
136Syringomyelia (HP:0003396)1.72016651
137Spinal cord lesions (HP:0100561)1.72016651
138Insomnia (HP:0100785)1.71871515
139Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.71741645
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.69874543
141Abnormality of the carotid arteries (HP:0005344)1.69785137
142Wide anterior fontanel (HP:0000260)1.69546397
143Proximal placement of thumb (HP:0009623)1.69176386
144Flared iliac wings (HP:0002869)1.69167409
145Smooth philtrum (HP:0000319)1.69015471
146Ulnar bowing (HP:0003031)1.68321719
147Optic nerve hypoplasia (HP:0000609)1.67534632
148Aplasia involving forearm bones (HP:0009822)1.67454278
149Absent forearm bone (HP:0003953)1.67454278
150Arteriovenous malformation (HP:0100026)1.67177493
151Absent radius (HP:0003974)1.66914507
152Abnormality of the duodenum (HP:0002246)1.66798221
153Insidious onset (HP:0003587)1.66693793
154Termporal pattern (HP:0011008)1.66693793
155* Partial agenesis of the corpus callosum (HP:0001338)1.66515889
156Pointed chin (HP:0000307)1.66278037
157Viral hepatitis (HP:0006562)1.66253842
158Overlapping toe (HP:0001845)1.65956069
159Broad face (HP:0000283)1.65671810
160Broad phalanges of the hand (HP:0009768)1.65573277
161Abnormality of the labia minora (HP:0012880)1.65220036
162Shallow orbits (HP:0000586)1.64918166
163Ectopic kidney (HP:0000086)1.64259789
164Renal hypoplasia (HP:0000089)1.64021830
165Volvulus (HP:0002580)1.63800286
166Midface retrusion (HP:0011800)1.63296267
167Abnormality of the nasal septum (HP:0000419)1.62985844
168Turricephaly (HP:0000262)1.62361187
169Atrioventricular canal defect (HP:0006695)1.60717292
170* Advanced eruption of teeth (HP:0006288)1.59855369
171* Broad ribs (HP:0000885)1.59839283
172Cubitus valgus (HP:0002967)1.59635692
173Long clavicles (HP:0000890)1.59341713
174Broad alveolar ridges (HP:0000187)1.59195168
175Visceral angiomatosis (HP:0100761)1.58391243
176Depressed nasal tip (HP:0000437)1.58179229
177Myelomeningocele (HP:0002475)1.56475740
178Deep philtrum (HP:0002002)1.56435223
179Intellectual disability, moderate (HP:0002342)1.55702549
180* Thoracic kyphosis (HP:0002942)1.54776319
181Neuroblastic tumors (HP:0004376)1.54591689
182Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.54591689
183Neuroblastoma (HP:0003006)1.54591689
184Primitive neuroectodermal tumor (HP:0030065)1.54591689
185Amblyopia (HP:0000646)1.54109184
186* Overfolded helix (HP:0000396)1.53489187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.69415780
2SMG14.56614842
3ICK4.49732662
4EEF2K4.49598867
5MKNK24.12192677
6MAP3K103.70550176
7MKNK13.34962551
8TRIB33.28449462
9MARK12.74333955
10CDC72.58439303
11TNIK2.27780183
12CCNB12.21938157
13TAF12.10740336
14SIK22.06964594
15TTN1.96462283
16SRPK11.74393825
17FGFR41.74289662
18BRD41.70244660
19FGFR21.69290276
20LATS11.64358133
21MAPK131.63952173
22MELK1.58962616
23BMPR1B1.55102904
24DYRK21.51410736
25CAMK1G1.51235807
26ERBB31.49758772
27FRK1.49340036
28RPS6KB21.48635776
29HIPK21.43930490
30SGK21.43831660
31MTOR1.40400324
32CDK191.39050661
33PRKG21.37733321
34YES11.33323731
35NUAK11.33199609
36ZAK1.31463372
37DYRK1A1.31082215
38NTRK31.30849596
39EIF2AK21.29737747
40TAOK21.18524751
41PDGFRA1.16790618
42CAMK1D1.15844318
43CDK41.14889301
44DYRK1B1.14589674
45MAP3K91.12486037
46NTRK21.10556412
47CDK31.09020062
48BCR1.08974482
49SCYL21.07884517
50PKN21.07499645
51BLK1.07369524
52CDK71.07077900
53TYRO31.05960532
54MAP3K121.05207614
55STK161.03789297
56ATR1.01784418
57SIK31.00017245
58MAP3K140.96734793
59MINK10.96647484
60OBSCN0.95543232
61EPHB20.94411816
62VRK20.91820332
63PIK3CA0.88942409
64PLK30.87216603
65IRAK20.87112702
66PKN10.86596459
67LATS20.86453632
68UHMK10.86410261
69STK110.85772012
70CDK60.80096882
71CDK120.79457356
72STK240.79437386
73ADRBK10.78720263
74SIK10.77135277
75SGK4940.75842822
76SGK2230.75842822
77PRKAA10.74480860
78PRPF4B0.68793711
79PHKG10.68732175
80PHKG20.68732175
81AKT10.68457858
82AKT30.68406988
83INSRR0.68084180
84ADRBK20.67537811
85PNCK0.67398498
86TLK10.66842994
87FGFR30.66815947
88MAP2K70.66610002
89OXSR10.66231617
90SGK30.65617433
91GSK3A0.64489211
92CDK90.64266686
93WNK40.63948956
94ALK0.63426459
95TNK20.62132219
96GRK70.61262517
97PASK0.60928693
98MAPK110.60898065
99RPS6KA20.60398467
100CHEK10.59799619
101ATM0.59229241
102CDK80.59203987
103MAPKAPK50.58193388
104NEK90.58009406
105TSSK60.57902508
106TTK0.57536937
107EPHA30.57108585
108MATK0.56570367
109NEK20.56328445
110MARK20.55931527
111CDK10.55144725
112GSK3B0.53516701
113MYLK0.52439713
114RIPK10.52394317
115DMPK0.52136625
116RPS6KB10.51842214
117AKT20.50910980
118SGK10.50394654
119PAK20.50183345
120PRKG10.49873215
121IRAK40.48934743
122ERBB20.48640863
123PRKAA20.47964388
124RPS6KC10.46477056
125RPS6KL10.46477056
126FGFR10.46351994
127MAP2K30.46130618
128MAPK90.46090951
129WNK10.45552061
130MAPK140.45410961
131CHEK20.44295710
132VRK10.43973639
133CSNK1E0.43878521
134RPS6KA60.42833690
135PRKDC0.42637363
136MAPK100.40774600
137CDK20.38998109
138CAMK40.38964659
139ROCK10.38503297
140PLK40.38294749
141MAPK80.38070937
142PDGFRB0.37268767
143MAP3K80.37233724
144RET0.37034523
145PRKD30.36773598
146NTRK10.36757933
147IRAK30.36222218
148STK30.36105476
149BRSK20.34828818
150MAPK120.33779817
151RPS6KA10.32511098
152AURKB0.29963227
153PIM10.29886056
154MAP3K70.29787317

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.29569189
2Mismatch repair_Homo sapiens_hsa034302.46578191
3Basal cell carcinoma_Homo sapiens_hsa052172.24185454
4Lysine degradation_Homo sapiens_hsa003102.14343600
5Axon guidance_Homo sapiens_hsa043602.05713438
6Spliceosome_Homo sapiens_hsa030401.92898635
7Thyroid cancer_Homo sapiens_hsa052161.92726947
8Taste transduction_Homo sapiens_hsa047421.91769153
9Wnt signaling pathway_Homo sapiens_hsa043101.87250991
10Nicotine addiction_Homo sapiens_hsa050331.85479777
11Phototransduction_Homo sapiens_hsa047441.73205217
12Hedgehog signaling pathway_Homo sapiens_hsa043401.72520942
13Selenocompound metabolism_Homo sapiens_hsa004501.71220252
14Non-small cell lung cancer_Homo sapiens_hsa052231.68888713
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65104156
16Longevity regulating pathway - mammal_Homo sapiens_hsa042111.54354575
17mRNA surveillance pathway_Homo sapiens_hsa030151.51985683
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50634362
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.49955750
20Melanoma_Homo sapiens_hsa052181.49482507
21Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.48467958
22Cell cycle_Homo sapiens_hsa041101.45557397
23Hippo signaling pathway_Homo sapiens_hsa043901.45409894
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.44077218
25Notch signaling pathway_Homo sapiens_hsa043301.41948917
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.40429286
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.40068340
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38381511
29Serotonergic synapse_Homo sapiens_hsa047261.37359637
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36764162
31RNA degradation_Homo sapiens_hsa030181.34756816
32Bladder cancer_Homo sapiens_hsa052191.34406291
33Homologous recombination_Homo sapiens_hsa034401.32073552
34Long-term depression_Homo sapiens_hsa047301.31983305
35mTOR signaling pathway_Homo sapiens_hsa041501.31488531
36Non-homologous end-joining_Homo sapiens_hsa034501.31444875
37DNA replication_Homo sapiens_hsa030301.31323868
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.30713848
39Glioma_Homo sapiens_hsa052141.30267115
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28986151
41Acute myeloid leukemia_Homo sapiens_hsa052211.28571445
42Colorectal cancer_Homo sapiens_hsa052101.24841059
43Nucleotide excision repair_Homo sapiens_hsa034201.24592502
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24200903
45Insulin signaling pathway_Homo sapiens_hsa049101.23124711
46MicroRNAs in cancer_Homo sapiens_hsa052061.20206787
47Pancreatic cancer_Homo sapiens_hsa052121.19474508
48Melanogenesis_Homo sapiens_hsa049161.16307484
49TGF-beta signaling pathway_Homo sapiens_hsa043501.12612962
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11701370
51Glutamatergic synapse_Homo sapiens_hsa047241.09565043
52Biosynthesis of amino acids_Homo sapiens_hsa012301.05994446
53Pathways in cancer_Homo sapiens_hsa052001.05239169
54VEGF signaling pathway_Homo sapiens_hsa043701.04408422
55B cell receptor signaling pathway_Homo sapiens_hsa046621.04208651
56Viral carcinogenesis_Homo sapiens_hsa052031.01679968
57AMPK signaling pathway_Homo sapiens_hsa041521.01084314
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.98968699
59Type II diabetes mellitus_Homo sapiens_hsa049300.96065793
60Morphine addiction_Homo sapiens_hsa050320.95758264
61Prostate cancer_Homo sapiens_hsa052150.95340050
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95250504
63Pentose phosphate pathway_Homo sapiens_hsa000300.94957588
64RNA polymerase_Homo sapiens_hsa030200.94246543
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91375053
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.90361272
67Ras signaling pathway_Homo sapiens_hsa040140.89814785
68RNA transport_Homo sapiens_hsa030130.89793848
69Glucagon signaling pathway_Homo sapiens_hsa049220.89284416
70Calcium signaling pathway_Homo sapiens_hsa040200.88678822
71Gap junction_Homo sapiens_hsa045400.86870721
72Circadian rhythm_Homo sapiens_hsa047100.86773364
73cAMP signaling pathway_Homo sapiens_hsa040240.86594893
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86562458
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86419611
76Arginine biosynthesis_Homo sapiens_hsa002200.85855925
77Endometrial cancer_Homo sapiens_hsa052130.85677579
78Rap1 signaling pathway_Homo sapiens_hsa040150.84897894
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84823394
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84622482
81Small cell lung cancer_Homo sapiens_hsa052220.84230261
82Cholinergic synapse_Homo sapiens_hsa047250.84133041
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83749041
84One carbon pool by folate_Homo sapiens_hsa006700.83284930
85Estrogen signaling pathway_Homo sapiens_hsa049150.82787280
86Viral myocarditis_Homo sapiens_hsa054160.80897744
87Oxytocin signaling pathway_Homo sapiens_hsa049210.79927861
88Insulin resistance_Homo sapiens_hsa049310.79733848
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79383569
90Basal transcription factors_Homo sapiens_hsa030220.78885811
91Adherens junction_Homo sapiens_hsa045200.78809794
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77461217
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76821294
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76444023
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76212139
96Prolactin signaling pathway_Homo sapiens_hsa049170.75286645
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74446712
98Circadian entrainment_Homo sapiens_hsa047130.74005667
99Hepatitis B_Homo sapiens_hsa051610.73969337
100FoxO signaling pathway_Homo sapiens_hsa040680.72456513
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70652042
102Renin secretion_Homo sapiens_hsa049240.70396963
103Systemic lupus erythematosus_Homo sapiens_hsa053220.70267665
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69550083
105Focal adhesion_Homo sapiens_hsa045100.68421248
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66712984
107Base excision repair_Homo sapiens_hsa034100.66662541
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65951670
109MAPK signaling pathway_Homo sapiens_hsa040100.64562868
110Tight junction_Homo sapiens_hsa045300.63270542
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.63266311
112Cocaine addiction_Homo sapiens_hsa050300.62229171
113Alcoholism_Homo sapiens_hsa050340.60720049
114Ether lipid metabolism_Homo sapiens_hsa005650.60083455
115HTLV-I infection_Homo sapiens_hsa051660.59360904
116Ovarian steroidogenesis_Homo sapiens_hsa049130.59268024
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58739137
118ErbB signaling pathway_Homo sapiens_hsa040120.57985359
119Vitamin B6 metabolism_Homo sapiens_hsa007500.57604706
120Autoimmune thyroid disease_Homo sapiens_hsa053200.56768807
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55939740
122Salivary secretion_Homo sapiens_hsa049700.55890115
123Proteoglycans in cancer_Homo sapiens_hsa052050.55718899
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54663649
125Dilated cardiomyopathy_Homo sapiens_hsa054140.54498739
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.54014678
127Renal cell carcinoma_Homo sapiens_hsa052110.53412407
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53304851
129Platelet activation_Homo sapiens_hsa046110.52837155
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.52246739
131ECM-receptor interaction_Homo sapiens_hsa045120.51225596
132Dopaminergic synapse_Homo sapiens_hsa047280.50110109
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49386084
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.48868550
135Inositol phosphate metabolism_Homo sapiens_hsa005620.48830164
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48219647
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47877052
138GABAergic synapse_Homo sapiens_hsa047270.47299214
139ABC transporters_Homo sapiens_hsa020100.46731553
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46149532
141T cell receptor signaling pathway_Homo sapiens_hsa046600.46137854
142Chronic myeloid leukemia_Homo sapiens_hsa052200.45598377
143p53 signaling pathway_Homo sapiens_hsa041150.42265501
144N-Glycan biosynthesis_Homo sapiens_hsa005100.42122436
145Long-term potentiation_Homo sapiens_hsa047200.41570482
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41150844
147Choline metabolism in cancer_Homo sapiens_hsa052310.40994416
148GnRH signaling pathway_Homo sapiens_hsa049120.40227260

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