AMFR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.14587054
2negative regulation of cell killing (GO:0031342)8.14587054
3cellular response to interleukin-15 (GO:0071350)6.96083616
4regulation of memory T cell differentiation (GO:0043380)6.48166946
5negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)6.33501750
6response to interleukin-15 (GO:0070672)5.61771710
7negative regulation of DNA-templated transcription, elongation (GO:0032785)5.57108205
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.50803487
9L-phenylalanine catabolic process (GO:0006559)5.50803487
10regulation of T cell mediated cytotoxicity (GO:0001914)5.35622076
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.25327169
12L-phenylalanine metabolic process (GO:0006558)5.25327169
13tolerance induction (GO:0002507)5.07287455
14alpha-linolenic acid metabolic process (GO:0036109)5.06764336
15positive regulation of T cell mediated cytotoxicity (GO:0001916)4.98156803
16positive regulation of defense response to virus by host (GO:0002230)4.95747856
17regulation of germinal center formation (GO:0002634)4.94397798
18sleep (GO:0030431)4.89505966
19aromatic amino acid family catabolic process (GO:0009074)4.79911807
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.73553737
21regulation of leukocyte mediated cytotoxicity (GO:0001910)4.53474663
22positive regulation of T-helper 1 type immune response (GO:0002827)4.45218598
23bile acid biosynthetic process (GO:0006699)4.41312087
24urea metabolic process (GO:0019627)4.40129941
25urea cycle (GO:0000050)4.40129941
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.39926323
27negative regulation of fibrinolysis (GO:0051918)4.39874521
28kynurenine metabolic process (GO:0070189)4.38797123
29positive regulation of T cell differentiation in thymus (GO:0033089)4.36940112
30glyoxylate metabolic process (GO:0046487)4.34838244
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.34242173
32cysteine metabolic process (GO:0006534)4.32960977
33lysine catabolic process (GO:0006554)4.29389210
34lysine metabolic process (GO:0006553)4.29389210
35regulation of activation of Janus kinase activity (GO:0010533)4.29157352
36sulfur amino acid catabolic process (GO:0000098)4.29132806
37protein carboxylation (GO:0018214)4.29128123
38peptidyl-glutamic acid carboxylation (GO:0017187)4.29128123
39negative T cell selection (GO:0043383)4.26710509
40regulation of cell killing (GO:0031341)4.19714515
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.18172125
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.16186895
43indole-containing compound catabolic process (GO:0042436)4.15824358
44indolalkylamine catabolic process (GO:0046218)4.15824358
45tryptophan catabolic process (GO:0006569)4.15824358
46complement activation, alternative pathway (GO:0006957)4.13925006
47positive regulation of osteoclast differentiation (GO:0045672)4.12689048
48negative thymic T cell selection (GO:0045060)4.11564885
49regulation of gamma-delta T cell differentiation (GO:0045586)4.08307661
50positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.08097531
51high-density lipoprotein particle remodeling (GO:0034375)4.07631462
52regulation of T-helper 1 type immune response (GO:0002825)4.04419070
53regulation of fibrinolysis (GO:0051917)4.03488434
54regulation of protein activation cascade (GO:2000257)4.00480999
55nitrogen cycle metabolic process (GO:0071941)3.98474577
56regulation of cholesterol homeostasis (GO:2000188)3.96650714
57tryptophan metabolic process (GO:0006568)3.93912312
58negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.93579706
59dicarboxylic acid biosynthetic process (GO:0043650)3.88133908
60dendritic cell chemotaxis (GO:0002407)3.84759682
61reverse cholesterol transport (GO:0043691)3.84195600
62positive regulation of T cell mediated immunity (GO:0002711)3.82106930
63regulation of complement activation (GO:0030449)3.77003270
64regulation of defense response to virus by host (GO:0050691)3.76467363
65glutamate metabolic process (GO:0006536)3.75647333
66bile acid metabolic process (GO:0008206)3.75055843
67regulation of triglyceride catabolic process (GO:0010896)3.74305698
68mast cell activation (GO:0045576)3.73623206
69lymph node development (GO:0048535)3.71781849
70response to gravity (GO:0009629)3.69710676
71homocysteine metabolic process (GO:0050667)3.68961958
72plasma lipoprotein particle clearance (GO:0034381)3.65892074
73positive regulation of cell killing (GO:0031343)3.64588609
74T-helper cell differentiation (GO:0042093)3.64062362
75CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.64062362
76cellular modified amino acid catabolic process (GO:0042219)3.63822764
77triglyceride homeostasis (GO:0070328)3.63274363
78acylglycerol homeostasis (GO:0055090)3.63274363
79histone H2A monoubiquitination (GO:0035518)3.63011932
80amino-acid betaine metabolic process (GO:0006577)3.62086194
81positive regulation of T cell cytokine production (GO:0002726)3.61660615
82regulation of T cell mediated immunity (GO:0002709)3.61615000
83cellular ketone body metabolic process (GO:0046950)3.61017183
84negative regulation of T cell mediated immunity (GO:0002710)3.59610772
85positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.59463080
86peptidyl-threonine dephosphorylation (GO:0035970)3.58390492
87tyrosine metabolic process (GO:0006570)3.54467125
88plasma lipoprotein particle remodeling (GO:0034369)3.54450145
89protein-lipid complex remodeling (GO:0034368)3.54450145
90macromolecular complex remodeling (GO:0034367)3.54450145
91positive regulation of fatty acid beta-oxidation (GO:0032000)3.49089515
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.47862600
93endoderm formation (GO:0001706)3.47449720
94negative regulation of sterol transport (GO:0032372)3.46628393
95negative regulation of cholesterol transport (GO:0032375)3.46628393
96interferon-gamma production (GO:0032609)3.42727320
97positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.42676621
98negative regulation of lymphocyte mediated immunity (GO:0002707)3.42659584
99tumor necrosis factor-mediated signaling pathway (GO:0033209)3.41972175
100alpha-amino acid catabolic process (GO:1901606)3.41949910
101serine family amino acid catabolic process (GO:0009071)3.41099078
102regulation of cholesterol esterification (GO:0010872)3.40507926
103mitotic cell cycle arrest (GO:0071850)3.40169396
104regulation of natural killer cell mediated immunity (GO:0002715)3.39710683
105regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.39710683
106regulation of B cell receptor signaling pathway (GO:0050855)3.38607408
107coenzyme catabolic process (GO:0009109)3.37480919
108response to muramyl dipeptide (GO:0032495)3.37127214
109aromatic amino acid family metabolic process (GO:0009072)3.37112170
110phospholipid efflux (GO:0033700)3.36083836
111rRNA catabolic process (GO:0016075)3.34881803
112aspartate family amino acid catabolic process (GO:0009068)3.33237103
113positive regulation of lipid catabolic process (GO:0050996)3.32519721
1142-oxoglutarate metabolic process (GO:0006103)3.31792280
115phospholipid homeostasis (GO:0055091)3.30038700
116ethanol oxidation (GO:0006069)3.29055224
117cellular defense response (GO:0006968)3.28821168
118short-chain fatty acid metabolic process (GO:0046459)3.28685571
119regulation of immunoglobulin secretion (GO:0051023)3.28660733
120mast cell degranulation (GO:0043303)3.28323417
121mast cell activation involved in immune response (GO:0002279)3.28323417
122regulation of gamma-delta T cell activation (GO:0046643)3.28173238
123cholesterol efflux (GO:0033344)3.27222364
124alpha-beta T cell differentiation involved in immune response (GO:0002293)3.24733747
125alpha-beta T cell activation involved in immune response (GO:0002287)3.24733747
126T cell differentiation involved in immune response (GO:0002292)3.24733747
127cellular amino acid catabolic process (GO:0009063)3.24483758
128negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.23399164
129regulation of fatty acid beta-oxidation (GO:0031998)3.22632735
130regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.19387636
131ketone body metabolic process (GO:1902224)3.18614529
132positive regulation of cell fate commitment (GO:0010455)3.16416171
133acetyl-CoA metabolic process (GO:0006084)3.15355475
134positive regulation of lipoprotein lipase activity (GO:0051006)3.15275168
135positive regulation of triglyceride lipase activity (GO:0061365)3.15275168
136regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.14480910
137positive regulation of natural killer cell mediated immunity (GO:0002717)3.14181076
138negative regulation of bone resorption (GO:0045779)3.13159598
139plasma lipoprotein particle assembly (GO:0034377)3.12258987
140fibrinolysis (GO:0042730)3.12184495
141negative regulation of leukocyte mediated immunity (GO:0002704)3.11603611
142cellular glucuronidation (GO:0052695)3.10852006
143fatty acid beta-oxidation (GO:0006635)3.10649967
144cytidine deamination (GO:0009972)3.10004836
145cytidine metabolic process (GO:0046087)3.10004836
146cytidine catabolic process (GO:0006216)3.10004836
147negative regulation of lipid storage (GO:0010888)3.09424975
148positive regulation of fatty acid biosynthetic process (GO:0045723)3.08196767
149bile acid and bile salt transport (GO:0015721)3.08185012
150regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.07615749
151protein-lipid complex assembly (GO:0065005)3.07467467
152fatty acid oxidation (GO:0019395)3.07135896
153positive regulation of triglyceride metabolic process (GO:0090208)3.06397820
154positive regulation of interleukin-17 production (GO:0032740)3.05087145
155regulation of natural killer cell activation (GO:0032814)3.04976899
156benzene-containing compound metabolic process (GO:0042537)3.04964061
157DNA deamination (GO:0045006)3.03204481
158lipid oxidation (GO:0034440)3.02664202
159negative regulation of lipase activity (GO:0060192)3.01614430
160dendritic cell migration (GO:0036336)2.99417728
161germ cell migration (GO:0008354)2.99034323
162drug catabolic process (GO:0042737)2.98760160
163monocarboxylic acid catabolic process (GO:0072329)2.98643424
164regulation of regulatory T cell differentiation (GO:0045589)2.98415268
165drug transmembrane transport (GO:0006855)2.98207268
166regulation of plasminogen activation (GO:0010755)2.97485803
167positive regulation of fatty acid oxidation (GO:0046321)2.97293764
168positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.96861559
169fatty acid catabolic process (GO:0009062)2.96444752
170cholesterol homeostasis (GO:0042632)2.95792187
171valine metabolic process (GO:0006573)2.95556177
172somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.95470866
173isotype switching (GO:0045190)2.95470866
174somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.95470866
175antigen processing and presentation of endogenous antigen (GO:0019883)2.95115662
176sterol homeostasis (GO:0055092)2.94058758
177positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93423237
178positive thymic T cell selection (GO:0045059)2.92941247
179negative regulation of innate immune response (GO:0045824)2.91347333
180organic acid catabolic process (GO:0016054)2.91253349
181carboxylic acid catabolic process (GO:0046395)2.91253349
182antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90124236
183positive regulation of prostaglandin secretion (GO:0032308)2.89051505
184regulation of cholesterol biosynthetic process (GO:0045540)2.89041490
185lipoprotein metabolic process (GO:0042157)2.87356448
186negative regulation of meiotic cell cycle (GO:0051447)2.87230209
187indolalkylamine metabolic process (GO:0006586)2.86855602
188carnitine metabolic process (GO:0009437)2.86336751
189complement activation, classical pathway (GO:0006958)2.86153215
190regulation of T cell receptor signaling pathway (GO:0050856)2.85300212
191alpha-beta T cell differentiation (GO:0046632)2.84884158
192regulation of interleukin-12 biosynthetic process (GO:0045075)2.84615756
193regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.84426486
194complement activation (GO:0006956)2.81928827
195regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.81813548
196epoxygenase P450 pathway (GO:0019373)2.81761481
197regulation of cholesterol metabolic process (GO:0090181)2.81759767
198positive regulation of cholesterol efflux (GO:0010875)2.81713225
199positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.81632440
200positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.80496516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.64371920
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.11993569
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.59956738
4RXR_22158963_ChIP-Seq_LIVER_Mouse5.47464706
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.84442811
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.71777227
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.56119329
8RUNX_20019798_ChIP-Seq_JUKART_Human3.97365037
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.94610003
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.39970213
11* FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.39398763
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.10970029
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.75590778
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.59564820
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.29391209
16* MYB_26560356_Chip-Seq_TH2_Human2.28943209
17CLOCK_20551151_ChIP-Seq_293T_Human2.27169065
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.23649802
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.20432347
20* GATA3_26560356_Chip-Seq_TH2_Human2.14538118
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09007776
22IRF1_19129219_ChIP-ChIP_H3396_Human2.08166219
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06525626
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.04505908
25* GATA3_27048872_Chip-Seq_THYMUS_Human1.99374533
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96172043
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95051272
28GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.89021070
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83545857
30SCL_19346495_ChIP-Seq_HPC-7_Human1.78868533
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77007884
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.70988643
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66670481
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61239566
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58711938
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.56668297
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54078182
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50045843
39MYB_26560356_Chip-Seq_TH1_Human1.49862963
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49232505
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48771129
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47357736
43UTX_26944678_Chip-Seq_JUKART_Human1.44601895
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44249756
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.44174215
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.43416957
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40656685
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.37800935
49GATA1_22025678_ChIP-Seq_K562_Human1.36229284
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33924423
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32296477
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28876802
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28441170
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.27661113
55TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22585581
56RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22487037
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.21615201
58MAF_26560356_Chip-Seq_TH1_Human1.20792335
59ZNF263_19887448_ChIP-Seq_K562_Human1.20181557
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19202421
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18241861
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18241861
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17181613
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14717643
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13438483
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12957215
67BCL6_27268052_Chip-Seq_Bcells_Human1.12944834
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.12708183
69VDR_22108803_ChIP-Seq_LS180_Human1.10595390
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09508659
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08873118
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08190982
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07976579
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07352487
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06631377
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.06476325
77LXR_22292898_ChIP-Seq_THP-1_Human1.06257312
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.05669136
79P300_27268052_Chip-Seq_Bcells_Human1.05319208
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05121839
81GATA1_19941826_ChIP-Seq_K562_Human1.04954524
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04089150
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03403490
84* HNF4A_19822575_ChIP-Seq_HepG2_Human1.02969837
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02616527
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01994353
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99797250
88EP300_21415370_ChIP-Seq_HL-1_Mouse0.99601786
89TBX20_22328084_ChIP-Seq_HEART_Mouse0.99478759
90TBX20_22080862_ChIP-Seq_HEART_Mouse0.99478759
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98630014
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97214152
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96226859
94MAF_26560356_Chip-Seq_TH2_Human0.95549675
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95262764
96HOXB7_26014856_ChIP-Seq_BT474_Human0.94916203
97KDM2B_26808549_Chip-Seq_K562_Human0.94767857
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.94206018
99GATA3_26560356_Chip-Seq_TH1_Human0.94080173
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93328917
101ESR1_21235772_ChIP-Seq_MCF-7_Human0.92190449
102EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91048086
103ZNF274_21170338_ChIP-Seq_K562_Hela0.90955553
104KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90858413
105SMRT_27268052_Chip-Seq_Bcells_Human0.90768699
106TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.90412169
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90308849
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89238878
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89079281
110TAF2_19829295_ChIP-Seq_ESCs_Human0.88610242
111* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88369291
112ER_23166858_ChIP-Seq_MCF-7_Human0.88360755
113* GATA2_19941826_ChIP-Seq_K562_Human0.88162570
114* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87584146
115* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.87315632
116ELF1_20517297_ChIP-Seq_JURKAT_Human0.87176324
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86836328
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86747670
119PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86424932
120* STAT1_20625510_ChIP-Seq_HELA_Human0.85799790
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85695048
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84508725
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84416833
124PRDM14_20953172_ChIP-Seq_ESCs_Human0.84007228
125FOXH1_21741376_ChIP-Seq_ESCs_Human0.83982258
126TP53_22573176_ChIP-Seq_HFKS_Human0.83942372
127TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83621554
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83573518
129AR_20517297_ChIP-Seq_VCAP_Human0.83393252
130BCOR_27268052_Chip-Seq_Bcells_Human0.83382942
131* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83235972
132GATA3_21878914_ChIP-Seq_MCF-7_Human0.81998973
133* SPI1_20517297_ChIP-Seq_HL60_Human0.81785517
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81666166
135DROSHA_22980978_ChIP-Seq_HELA_Human0.81568845
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81017217
137FOXA1_25329375_ChIP-Seq_VCAP_Human0.80613855
138FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80613855
139RACK7_27058665_Chip-Seq_MCF-7_Human0.80397534
140PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80292694
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80060485
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80004092
143* GATA2_21666600_ChIP-Seq_HMVEC_Human0.79891996
144RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79639111
145FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78850475
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.77417705
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76609638
148* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.76130344
149* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.76050501
150SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75963157
151GATA4_25053715_ChIP-Seq_YYC3_Human0.75683971
152WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75438109
153DNAJC2_21179169_ChIP-ChIP_NT2_Human0.75365907
154CREB1_26743006_Chip-Seq_LNCaP_Human0.74414912
155IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.73668259
156KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73573894
157GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73474059
158NFIB_24661679_ChIP-Seq_LUNG_Mouse0.73416980
159EGR1_19032775_ChIP-ChIP_M12_Human0.73252473
160BCAT_22108803_ChIP-Seq_LS180_Human0.72950540
161NR3C1_23031785_ChIP-Seq_PC12_Mouse0.72773598
162RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72500285
163ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72494514
164KDM2B_26808549_Chip-Seq_DND41_Human0.72120180
165* CJUN_26792858_Chip-Seq_BT549_Human0.71564813
166ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71127154
167SOX2_20726797_ChIP-Seq_SW620_Human0.71033804
168KDM2B_26808549_Chip-Seq_JURKAT_Human0.69443885
169PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69347025
170RXR_22108803_ChIP-Seq_LS180_Human0.68654554
171KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.68530411
172RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.68488214
173* TP63_23658742_ChIP-Seq_EP156T_Human0.68188562
174CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.67089393
175SMAD4_21741376_ChIP-Seq_HESCs_Human0.67009567
176GATA1_19941827_ChIP-Seq_MEL_Mouse0.66790460
177VDR_24787735_ChIP-Seq_THP-1_Human0.66547987
178AHR_22903824_ChIP-Seq_MCF-7_Human0.66461156
179ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.66370907
180SOX9_24532713_ChIP-Seq_HFSC_Mouse0.66315626
181FOXA1_25552417_ChIP-Seq_VCAP_Human0.66034069
182TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.65037630
183PIAS1_25552417_ChIP-Seq_VCAP_Human0.64156177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.55349366
2MP0005360_urolithiasis6.04654210
3MP0005365_abnormal_bile_salt5.14371905
4MP0005085_abnormal_gallbladder_physiolo4.83715838
5MP0003724_increased_susceptibility_to4.62542899
6MP0005671_abnormal_response_to4.35669299
7MP0008875_abnormal_xenobiotic_pharmacok3.91555820
8MP0003252_abnormal_bile_duct3.43436940
9MP0003436_decreased_susceptibility_to3.28657923
10MP0003763_abnormal_thymus_physiology3.18903180
11MP0010329_abnormal_lipoprotein_level3.16681570
12MP0005000_abnormal_immune_tolerance3.01966168
13MP0000685_abnormal_immune_system3.00955100
14MP0009840_abnormal_foam_cell2.89138189
15MP0003191_abnormal_cellular_cholesterol2.83293251
16MP0002876_abnormal_thyroid_physiology2.63335772
17MP0000465_gastrointestinal_hemorrhage2.61918804
18MP0003195_calcinosis2.60468245
19MP0005083_abnormal_biliary_tract2.60301339
20MP0001835_abnormal_antigen_presentation2.48580492
21MP0003806_abnormal_nucleotide_metabolis2.44587363
22MP0004147_increased_porphyrin_level2.42178809
23MP0004885_abnormal_endolymph2.37218287
24MP0005332_abnormal_amino_acid2.35253292
25MP0001800_abnormal_humoral_immune2.34389935
26MP0001533_abnormal_skeleton_physiology2.33931394
27MP0004947_skin_inflammation2.31594941
28MP0002723_abnormal_immune_serum2.30407010
29MP0003705_abnormal_hypodermis_morpholog2.27329083
30MP0009785_altered_susceptibility_to2.27120378
31MP0001666_abnormal_nutrient_absorption2.24318055
32MP0002148_abnormal_hypersensitivity_rea2.20321285
33MP0003866_abnormal_defecation2.02817919
34MP0006072_abnormal_retinal_apoptosis2.01322616
35MP0005075_abnormal_melanosome_morpholog1.98955294
36MP0002118_abnormal_lipid_homeostasis1.98804990
37MP0001819_abnormal_immune_cell1.98756192
38MP0002452_abnormal_antigen_presenting1.94947360
39MP0003878_abnormal_ear_physiology1.93568318
40MP0005377_hearing/vestibular/ear_phenot1.93568318
41MP0002420_abnormal_adaptive_immunity1.92392710
42MP0000609_abnormal_liver_physiology1.92164724
43MP0001501_abnormal_sleep_pattern1.91546009
44MP0002009_preneoplasia1.84705106
45MP0002933_joint_inflammation1.84026877
46MP0005387_immune_system_phenotype1.75051290
47MP0001790_abnormal_immune_system1.75051290
48MP0003329_amyloid_beta_deposits1.72884237
49MP0005025_abnormal_response_to1.72023788
50MP0000604_amyloidosis1.69627795
51MP0002138_abnormal_hepatobiliary_system1.68852749
52MP0002419_abnormal_innate_immunity1.67804569
53MP0004130_abnormal_muscle_cell1.59812605
54MP0002405_respiratory_system_inflammati1.59393700
55MP0003868_abnormal_feces_composition1.58520844
56MP0005319_abnormal_enzyme/_coenzyme1.55194965
57MP0003300_gastrointestinal_ulcer1.52642918
58MP0004019_abnormal_vitamin_homeostasis1.48328685
59MP0005584_abnormal_enzyme/coenzyme_acti1.47542227
60MP0010155_abnormal_intestine_physiology1.47332977
61MP0002166_altered_tumor_susceptibility1.47163534
62MP0003879_abnormal_hair_cell1.45589540
63MP0001845_abnormal_inflammatory_respons1.44767871
64MP0002837_dystrophic_cardiac_calcinosis1.43692197
65MP0002398_abnormal_bone_marrow1.42171133
66MP0000689_abnormal_spleen_morphology1.38466917
67MP0000716_abnormal_immune_system1.38439205
68MP0003828_pulmonary_edema1.36710116
69MP0001348_abnormal_lacrimal_gland1.36441928
70MP0002722_abnormal_immune_system1.33589103
71MP0001919_abnormal_reproductive_system1.31134809
72MP0009643_abnormal_urine_homeostasis1.30889735
73MP0008438_abnormal_cutaneous_collagen1.29698751
74MP0002102_abnormal_ear_morphology1.28865312
75MP0000703_abnormal_thymus_morphology1.28498621
76MP0003690_abnormal_glial_cell1.26975476
77MP0009780_abnormal_chondrocyte_physiolo1.20767860
78MP0010234_abnormal_vibrissa_follicle1.20766603
79MP0002998_abnormal_bone_remodeling1.17630786
80MP0005390_skeleton_phenotype1.17567412
81MP0003656_abnormal_erythrocyte_physiolo1.14551943
82MP0005058_abnormal_lysosome_morphology1.11499011
83MP0003638_abnormal_response/metabolism_1.07286294
84MP0009384_cardiac_valve_regurgitation1.07031677
85MP0001986_abnormal_taste_sensitivity1.06481043
86MP0004145_abnormal_muscle_electrophysio1.04950864
87MP0005666_abnormal_adipose_tissue1.03761141
88MP0003303_peritoneal_inflammation1.03264236
89MP0003075_altered_response_to1.02654865
90MP0002006_tumorigenesis1.02605236
91MP0002429_abnormal_blood_cell1.01157592
92MP0004381_abnormal_hair_follicle0.99993062
93MP0008877_abnormal_DNA_methylation0.99813992
94MP0005167_abnormal_blood-brain_barrier0.99746828
95MP0002078_abnormal_glucose_homeostasis0.98859275
96MP0005670_abnormal_white_adipose0.98729093
97MP0008872_abnormal_physiological_respon0.98479927
98MP0008775_abnormal_heart_ventricle0.97478202
99MP0002971_abnormal_brown_adipose0.97332454
100MP0005174_abnormal_tail_pigmentation0.96582780
101MP0000598_abnormal_liver_morphology0.95945126
102MP0002909_abnormal_adrenal_gland0.95684701
103MP0005310_abnormal_salivary_gland0.95068228
104MP0010368_abnormal_lymphatic_system0.94867559
105MP0005646_abnormal_pituitary_gland0.94453084
106MP0005647_abnormal_sex_gland0.92671115
107MP0005253_abnormal_eye_physiology0.89118798
108MP0004185_abnormal_adipocyte_glucose0.88633244
109MP0005451_abnormal_body_composition0.87345545
110MP0003646_muscle_fatigue0.86784596
111MP0009333_abnormal_splenocyte_physiolog0.86041562
112MP0005464_abnormal_platelet_physiology0.84919129
113MP0003011_delayed_dark_adaptation0.84895799
114MP0005535_abnormal_body_temperature0.84824808
115MP0008961_abnormal_basal_metabolism0.84374583
116MP0005636_abnormal_mineral_homeostasis0.83558904
117MP0004043_abnormal_pH_regulation0.82905898
118MP0005551_abnormal_eye_electrophysiolog0.82250224
119MP0009764_decreased_sensitivity_to0.81579232
120MP0005334_abnormal_fat_pad0.80372140
121MP0001764_abnormal_homeostasis0.80190014
122MP0001853_heart_inflammation0.79187597
123MP0003795_abnormal_bone_structure0.79113109
124MP0001851_eye_inflammation0.78311849
125MP0009642_abnormal_blood_homeostasis0.76747017
126MP0005408_hypopigmentation0.75827399
127MP0001756_abnormal_urination0.75535813
128MP0001542_abnormal_bone_strength0.74505073
129MP0002254_reproductive_system_inflammat0.74108909
130MP0009763_increased_sensitivity_to0.73846395
131MP0005248_abnormal_Harderian_gland0.73360655
132MP0002168_other_aberrant_phenotype0.73133268
133MP0000383_abnormal_hair_follicle0.73041713
134MP0005375_adipose_tissue_phenotype0.72986106
135MP0001243_abnormal_dermal_layer0.72253486
136MP0001502_abnormal_circadian_rhythm0.71253427
137MP0005220_abnormal_exocrine_pancreas0.70878438
138MP0005389_reproductive_system_phenotype0.70673452
139MP0001765_abnormal_ion_homeostasis0.69996934
140MP0002090_abnormal_vision0.69924196
141MP0004858_abnormal_nervous_system0.68392816
142MP0005166_decreased_susceptibility_to0.67729140
143MP0008469_abnormal_protein_level0.67365216
144MP0006082_CNS_inflammation0.66193678
145MP0000747_muscle_weakness0.64976603
146MP0000013_abnormal_adipose_tissue0.64287689
147MP0001873_stomach_inflammation0.64096472
148MP0009053_abnormal_anal_canal0.62253710
149MP0005448_abnormal_energy_balance0.61774916
150MP0000639_abnormal_adrenal_gland0.60910820
151MP0003633_abnormal_nervous_system0.60555409
152MP0002295_abnormal_pulmonary_circulatio0.60361148
153MP0003045_fibrosis0.60275220
154MP0004087_abnormal_muscle_fiber0.59352426
155MP0002877_abnormal_melanocyte_morpholog0.59089993
156MP0002896_abnormal_bone_mineralization0.58883227
157MP0000751_myopathy0.57097536
158MP0003172_abnormal_lysosome_physiology0.56551263
159MP0008874_decreased_physiological_sensi0.56488447
160MP0005275_abnormal_skin_tensile0.55858181
161MP0005330_cardiomyopathy0.54053551
162MP0001958_emphysema0.53915664
163MP0002269_muscular_atrophy0.53291068
164MP0002136_abnormal_kidney_physiology0.53102773
165MP0000230_abnormal_systemic_arterial0.51524607
166MP0001944_abnormal_pancreas_morphology0.50946526
167MP0003953_abnormal_hormone_level0.49617172
168MP0002928_abnormal_bile_duct0.49559217
169MP0004036_abnormal_muscle_relaxation0.48612942
170MP0000249_abnormal_blood_vessel0.48162693
171MP0003186_abnormal_redox_activity0.47947925
172MP0001661_extended_life_span0.46404540
173MP0000003_abnormal_adipose_tissue0.46205881
174MP0003566_abnormal_cell_adhesion0.45481631
175MP0000920_abnormal_myelination0.44399721

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)7.38402536
2Deep venous thrombosis (HP:0002625)6.21406543
3Retrobulbar optic neuritis (HP:0100654)5.41616018
4Optic neuritis (HP:0100653)5.41616018
5Xanthomatosis (HP:0000991)5.23730022
6Severe combined immunodeficiency (HP:0004430)5.19247797
7Intrahepatic cholestasis (HP:0001406)5.17185569
8Abnormality of aromatic amino acid family metabolism (HP:0004338)5.13005325
9Myositis (HP:0100614)5.01072194
10T lymphocytopenia (HP:0005403)4.97679905
11Orchitis (HP:0100796)4.85722460
12Abnormality of T cell number (HP:0011839)4.73106034
13Abnormality of monocarboxylic acid metabolism (HP:0010996)4.65021397
14Abnormality of eosinophils (HP:0001879)4.62553018
15Complement deficiency (HP:0004431)4.57291372
16Prostate neoplasm (HP:0100787)4.26941895
17Conical tooth (HP:0000698)4.24891184
18Hyperlipoproteinemia (HP:0010980)4.20452108
19Stomach cancer (HP:0012126)4.11946099
20Hypobetalipoproteinemia (HP:0003563)4.04977124
21Prolonged partial thromboplastin time (HP:0003645)4.04948243
22Combined immunodeficiency (HP:0005387)3.99815012
23Ketosis (HP:0001946)3.94268170
24Thyroiditis (HP:0100646)3.93325915
25Abnormality of the common coagulation pathway (HP:0010990)3.82130174
26Renal cortical cysts (HP:0000803)3.80548217
27Persistence of primary teeth (HP:0006335)3.78233101
28Abnormality of T cells (HP:0002843)3.73790491
29Hypoglycemic coma (HP:0001325)3.68362914
30Hypoalphalipoproteinemia (HP:0003233)3.65991769
31Hyperammonemia (HP:0001987)3.60484450
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.60414485
33Keratoconjunctivitis (HP:0001096)3.59844032
34Hypolipoproteinemia (HP:0010981)3.57141648
35Epidermoid cyst (HP:0200040)3.52664188
36Ketoacidosis (HP:0001993)3.44771680
37Stomatitis (HP:0010280)3.44122241
38Keratoconjunctivitis sicca (HP:0001097)3.33496509
39Abnormality of complement system (HP:0005339)3.33346154
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.26497106
41Joint hemorrhage (HP:0005261)3.18448416
42Abnormality of the intrinsic pathway (HP:0010989)3.15875537
43Abnormality of glycine metabolism (HP:0010895)3.09261824
44Abnormality of serine family amino acid metabolism (HP:0010894)3.09261824
45Pulmonary infiltrates (HP:0002113)3.08968558
46Myocardial infarction (HP:0001658)3.07221836
47Hyperglycinemia (HP:0002154)3.02941005
48Abnormality of T cell physiology (HP:0011840)3.00114136
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.97737169
50Hyperglycinuria (HP:0003108)2.97177351
51Elevated erythrocyte sedimentation rate (HP:0003565)2.95361327
52Eosinophilia (HP:0001880)2.89892315
53Abnormality of the renal cortex (HP:0011035)2.88601709
54Skin nodule (HP:0200036)2.85198787
55Brittle hair (HP:0002299)2.83635732
56Fat malabsorption (HP:0002630)2.83597862
57Eczematoid dermatitis (HP:0000976)2.80441032
58Leukocytosis (HP:0001974)2.76145994
59Pustule (HP:0200039)2.75880536
60Pulmonary fibrosis (HP:0002206)2.75112521
61Hypercholesterolemia (HP:0003124)2.73152761
62Abnormality of fatty-acid metabolism (HP:0004359)2.72348877
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.71124090
64Type II lissencephaly (HP:0007260)2.69339974
65Abnormality of the prostate (HP:0008775)2.67873763
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.64799032
67Hepatocellular carcinoma (HP:0001402)2.62381322
68Anhidrosis (HP:0000970)2.61225517
69Joint swelling (HP:0001386)2.61121445
70Hypoglycemic seizures (HP:0002173)2.59019564
71Clumsiness (HP:0002312)2.58363791
72Granulocytopenia (HP:0001913)2.53145011
73Gout (HP:0001997)2.52828546
74Mitral stenosis (HP:0001718)2.52046340
75Hyperinsulinemic hypoglycemia (HP:0000825)2.51912131
76Systemic lupus erythematosus (HP:0002725)2.46800600
77Abnormality of methionine metabolism (HP:0010901)2.45258555
78Recurrent bronchitis (HP:0002837)2.44364735
79Abnormality of purine metabolism (HP:0004352)2.41814157
80Encephalitis (HP:0002383)2.37851442
81Arterial thrombosis (HP:0004420)2.37677389
82Hyperbilirubinemia (HP:0002904)2.34824915
83Amyloidosis (HP:0011034)2.33960079
84Congenital stationary night blindness (HP:0007642)2.30225037
85Vasculitis (HP:0002633)2.29161266
86Facial diplegia (HP:0001349)2.25553819
87Asplenia (HP:0001746)2.25086014
88Conjugated hyperbilirubinemia (HP:0002908)2.24904623
89Hemoptysis (HP:0002105)2.24140906
90Abnormality of the proximal phalanges of the hand (HP:0009834)2.23280086
91Keratitis (HP:0000491)2.22384326
92Cholelithiasis (HP:0001081)2.21227320
93Delayed CNS myelination (HP:0002188)2.20925320
94Abnormal gallbladder morphology (HP:0012437)2.20774175
95Abnormality of the Achilles tendon (HP:0005109)2.20010216
96Hydroxyprolinuria (HP:0003080)2.16515896
97Abnormality of proline metabolism (HP:0010907)2.16515896
98Sensorimotor neuropathy (HP:0007141)2.15203748
99Spastic diplegia (HP:0001264)2.14758013
100Growth hormone excess (HP:0000845)2.14707842
101Gangrene (HP:0100758)2.14625447
102Abnormality of nucleobase metabolism (HP:0010932)2.13353011
103Metabolic alkalosis (HP:0200114)2.12533385
104Aplasia/Hypoplasia of the spleen (HP:0010451)2.11888899
105Spontaneous abortion (HP:0005268)2.11255775
106Cholecystitis (HP:0001082)2.10908160
107Abnormal gallbladder physiology (HP:0012438)2.10908160
108Glomerulonephritis (HP:0000099)2.10481298
109Vascular calcification (HP:0004934)2.10165696
110Abnormal delayed hypersensitivity skin test (HP:0002963)2.10002836
111Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.09522906
112Esophageal varix (HP:0002040)2.08906597
113Hyperglycemia (HP:0003074)2.07200727
114Adactyly (HP:0009776)2.06670064
115Late onset (HP:0003584)2.06125936
116Neonatal onset (HP:0003623)2.05441905
117Glomerulopathy (HP:0100820)2.04891725
118Cardiovascular calcification (HP:0011915)2.04831774
119Vertigo (HP:0002321)2.02886172
120Abnormality of dental color (HP:0011073)2.00332855
121Myoglobinuria (HP:0002913)1.99743283
122Acanthocytosis (HP:0001927)1.98839578
123Neoplasm of head and neck (HP:0012288)1.98327896
124Esophageal neoplasm (HP:0100751)1.98327896
125Metabolic acidosis (HP:0001942)1.98280530
126Back pain (HP:0003418)1.98137075
127Premature loss of primary teeth (HP:0006323)1.97743368
128Hypoplasia of the uterus (HP:0000013)1.95208301
129Anorexia (HP:0002039)1.94698588
130Chronic diarrhea (HP:0002028)1.93593542
131Recurrent gram-negative bacterial infections (HP:0005420)1.93293173
132Abnormality of the renal collecting system (HP:0004742)1.92081957
133Hypoplasia of the pons (HP:0012110)1.91411768
134Cerebral inclusion bodies (HP:0100314)1.90320677
135Recurrent fungal infections (HP:0002841)1.89336129
136Duplicated collecting system (HP:0000081)1.88759190
137Turricephaly (HP:0000262)1.88192683
138Pulmonary embolism (HP:0002204)1.87947601
139Steatorrhea (HP:0002570)1.87889775
140Lymphangioma (HP:0100764)1.87330847
141Neurofibrillary tangles (HP:0002185)1.86865295
142Abnormality of serum amino acid levels (HP:0003112)1.86326493
143Abnormality of B cell number (HP:0010975)1.85796613
144Chronic mucocutaneous candidiasis (HP:0002728)1.85761205
145Recurrent cutaneous fungal infections (HP:0011370)1.85761205
146Peritonitis (HP:0002586)1.85265984
147Abnormality of the endocardium (HP:0004306)1.84938402
148Nephritis (HP:0000123)1.83892936
149Increased IgM level (HP:0003496)1.83574160
150Global brain atrophy (HP:0002283)1.82961854
151Abnormality of the pleura (HP:0002103)1.81731562
152Enlarged kidneys (HP:0000105)1.79494415
153Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78938854
154Dicarboxylic aciduria (HP:0003215)1.78938854
155Bundle branch block (HP:0011710)1.78886159
156Decreased subcutaneous fat (HP:0001002)1.78810101
157Short tibia (HP:0005736)1.78409826
158Polycythemia (HP:0001901)1.78234113
159Polyneuropathy (HP:0001271)1.77786953
160Gastrointestinal stroma tumor (HP:0100723)1.76710332
161Abnormal cartilage morphology (HP:0002763)1.76651742
162Hypotrichosis (HP:0001006)1.75822482
163Abolished electroretinogram (ERG) (HP:0000550)1.75187881
164Abnormality of the pons (HP:0007361)1.74815764
165Hemorrhage of the eye (HP:0011885)1.74683266
166Abnormality of the pericardium (HP:0001697)1.74077280
167Tongue fasciculations (HP:0001308)1.72384382
168Stroke (HP:0001297)1.72215266
169Abnormality of the gallbladder (HP:0005264)1.72142587
170Malnutrition (HP:0004395)1.71909905
171Increased density of long bones (HP:0006392)1.71605621
172Irritability (HP:0000737)1.71393570
173Menorrhagia (HP:0000132)1.70626535
174Protuberant abdomen (HP:0001538)1.68537552
175Arthralgia (HP:0002829)1.68003241
176IgA deficiency (HP:0002720)1.67884364
177Aplasia/hypoplasia of the uterus (HP:0008684)1.66735248
178Alkalosis (HP:0001948)1.66244784
179Status epilepticus (HP:0002133)1.65762456
180Hypokalemic alkalosis (HP:0001949)1.65621071
181Achilles tendon contracture (HP:0001771)1.65582712
182Gastrointestinal infarctions (HP:0005244)1.64996886
183B lymphocytopenia (HP:0010976)1.63869746
184Progressive microcephaly (HP:0000253)1.62633927
185Hyperuricemia (HP:0002149)1.62364367
186Increased purine levels (HP:0004368)1.62364367
187Exercise-induced myalgia (HP:0003738)1.61674253
188Mediastinal lymphadenopathy (HP:0100721)1.61149263
189Abnormality of transition element cation homeostasis (HP:0011030)1.61074823
190Pancreatitis (HP:0001733)1.60868058
191Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.60652381
192Reticulocytosis (HP:0001923)1.60328484
193Urinary glycosaminoglycan excretion (HP:0003541)1.60189224
194Mucopolysacchariduria (HP:0008155)1.60189224
195Gingival bleeding (HP:0000225)1.59360239
196Nephronophthisis (HP:0000090)1.59183384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.24469782
2MAP2K24.40969621
3TRIB34.16794147
4MAP3K144.04709470
5TLK13.30563349
6PKN23.13402683
7SIK13.09501634
8ERN13.02444445
9BCKDK2.73785663
10FGFR42.47621842
11RIPK12.22176752
12IKBKB2.17180119
13INSRR2.16176631
14TESK22.10374334
15PTK62.07836555
16TAOK32.03559249
17ZAK2.00105923
18IKBKE1.91284024
19TTN1.90097191
20EPHB11.88431877
21MAP4K11.76847232
22FES1.65231332
23ADRBK21.63768711
24LATS11.56020385
25FRK1.51941283
26PDGFRA1.49005826
27KSR21.40569347
28MUSK1.40103743
29MAP2K41.39253795
30KIT1.37149557
31KDR1.35944001
32RET1.34198548
33FGFR21.33325430
34EPHA31.31603524
35SIK21.29596911
36DAPK21.29136238
37PRKD31.29136091
38MATK1.27274978
39MAP3K21.27253411
40GRK71.25470276
41ZAP701.25311132
42PRKCH1.24452483
43MST1R1.20663464
44MAP4K21.19261036
45NTRK11.19029217
46CHUK1.18693808
47JAK11.18543954
48ERBB41.13330923
49SYK1.11374905
50GRK11.09099944
51CAMK1D1.08645056
52CAMK1G1.05735849
53NUAK11.04919386
54PTK21.04793143
55MAPK71.04725648
56EIF2AK21.04162623
57JAK21.03815769
58CAMKK11.03489015
59JAK31.02620034
60MAP3K71.02459555
61NEK91.00703777
62CSF1R0.98965463
63MAP3K100.98350467
64BMPR20.97175566
65LCK0.94891236
66LMTK20.93116753
67TGFBR20.92586391
68FGFR30.92125018
69BMX0.91927858
70SGK30.91281042
71PAK30.90632206
72PIM10.90343093
73FER0.89177409
74ITK0.87584372
75LRRK20.87358448
76PDPK10.84746232
77PHKG20.82789251
78PHKG10.82789251
79MAPKAPK30.82782540
80RPS6KA20.81610525
81TYRO30.80310753
82FLT30.79555876
83ACVR1B0.79164085
84OBSCN0.78767133
85PDK30.77732189
86PDK40.77732189
87PAK60.77458685
88WNK40.77211938
89MET0.76336037
90TYK20.76150122
91DMPK0.75302086
92MAP3K10.74633611
93PIK3CA0.73406670
94HCK0.73175385
95MAPK110.72959434
96PRKAA20.72405365
97CDK80.71637938
98DDR20.71191236
99LYN0.71107428
100PRKD10.69962316
101PDK10.69713446
102IGF1R0.69705284
103SGK2230.68148029
104SGK4940.68148029
105TBK10.68023902
106PIK3CG0.67781571
107ERBB20.67381714
108MAP2K10.65711974
109MAP3K90.65595203
110GSK3A0.65211648
111BTK0.65060413
112CSK0.64873168
113EEF2K0.63351280
114PDGFRB0.63248974
115SCYL20.63166130
116TAOK10.62992661
117STK380.62133120
118PTK2B0.60867484
119MOS0.60602558
120PINK10.60028622
121TRPM70.58023996
122EPHA40.57817473
123PRKAA10.56161019
124DYRK1B0.55780949
125ROCK10.54759488
126PRKCZ0.54166883
127GRK60.53358326
128MAP3K40.53090640
129MAP3K30.53011056
130RIPK40.52477807
131MAP3K130.52091758
132ARAF0.51606807
133SGK20.51288960
134MAP2K30.51217103
135LIMK10.51009685
136STK110.50634579
137IRAK10.50459388
138RPS6KA60.50152485
139MAPKAPK20.49970998
140PRKACG0.49927729
141MAPK120.49431434
142ICK0.49028719
143MARK30.47437441
144MTOR0.47110235
145GRK50.46730403
146CDK60.42788443
147WNK10.41933429
148RPS6KL10.41108416
149RPS6KC10.41108416
150EGFR0.40904640
151MAPK40.40111702
152ABL20.40025006
153PRKCQ0.39483845
154MAP2K60.35443464
155MAPK30.35310327
156ABL10.34685187
157INSR0.32703670
158TNK20.32298061
159STK100.31678915
160RAF10.30242971
161RPS6KA10.30201195
162IRAK40.29248409
163CAMKK20.28844597
164ADRBK10.28089533
165TEC0.26534958
166NEK60.26016837
167MST40.24900254
168RPS6KA50.24545439
169TIE10.24362929
170PRKCD0.23605537
171FYN0.23189966

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.22571988
2Primary immunodeficiency_Homo sapiens_hsa053403.84262911
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.70128239
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17454944
5Arginine biosynthesis_Homo sapiens_hsa002202.89451977
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.85302020
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.80299324
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.75910727
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.69065441
10Fatty acid degradation_Homo sapiens_hsa000712.51977702
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.49874768
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47901296
13Complement and coagulation cascades_Homo sapiens_hsa046102.36900012
14Tryptophan metabolism_Homo sapiens_hsa003802.29679119
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22749094
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.22290480
17Graft-versus-host disease_Homo sapiens_hsa053322.18861546
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.17084675
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16087694
20T cell receptor signaling pathway_Homo sapiens_hsa046602.04608377
21Butanoate metabolism_Homo sapiens_hsa006502.04085848
22PPAR signaling pathway_Homo sapiens_hsa033202.02598164
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.98191431
24Fatty acid metabolism_Homo sapiens_hsa012121.97873971
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94115005
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91005341
27Propanoate metabolism_Homo sapiens_hsa006401.88973729
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86580289
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86408269
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79807518
31Bile secretion_Homo sapiens_hsa049761.74014245
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71789170
33Caffeine metabolism_Homo sapiens_hsa002321.65059637
34Peroxisome_Homo sapiens_hsa041461.63399458
35B cell receptor signaling pathway_Homo sapiens_hsa046621.58948586
36TNF signaling pathway_Homo sapiens_hsa046681.57847332
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57389759
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56359792
39Antigen processing and presentation_Homo sapiens_hsa046121.56279341
40Linoleic acid metabolism_Homo sapiens_hsa005911.56239333
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.55054476
42Staphylococcus aureus infection_Homo sapiens_hsa051501.54317566
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48900060
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47162447
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41901198
46beta-Alanine metabolism_Homo sapiens_hsa004101.40666458
47Allograft rejection_Homo sapiens_hsa053301.38249364
48Chemical carcinogenesis_Homo sapiens_hsa052041.35183183
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34901954
50Histidine metabolism_Homo sapiens_hsa003401.32988340
51Autoimmune thyroid disease_Homo sapiens_hsa053201.32589640
52Sulfur metabolism_Homo sapiens_hsa009201.31124606
53Hematopoietic cell lineage_Homo sapiens_hsa046401.29708226
54Circadian rhythm_Homo sapiens_hsa047101.29318136
55Osteoclast differentiation_Homo sapiens_hsa043801.28327887
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.27540777
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24952594
58Arachidonic acid metabolism_Homo sapiens_hsa005901.24520966
59Starch and sucrose metabolism_Homo sapiens_hsa005001.23980151
60Pyruvate metabolism_Homo sapiens_hsa006201.19038171
61Selenocompound metabolism_Homo sapiens_hsa004501.13691966
62ABC transporters_Homo sapiens_hsa020101.11883258
63Phenylalanine metabolism_Homo sapiens_hsa003601.11377247
64Measles_Homo sapiens_hsa051621.09593655
65Fat digestion and absorption_Homo sapiens_hsa049751.07925590
66Phototransduction_Homo sapiens_hsa047441.07751425
67Retinol metabolism_Homo sapiens_hsa008301.06516399
68Leishmaniasis_Homo sapiens_hsa051401.04479750
69Fatty acid elongation_Homo sapiens_hsa000621.03508465
70Carbon metabolism_Homo sapiens_hsa012001.01482461
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99563744
72Malaria_Homo sapiens_hsa051440.96706119
73Tyrosine metabolism_Homo sapiens_hsa003500.95437510
74Herpes simplex infection_Homo sapiens_hsa051680.94715000
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.92780315
76Fatty acid biosynthesis_Homo sapiens_hsa000610.92449887
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92322106
78Biosynthesis of amino acids_Homo sapiens_hsa012300.92259751
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.91723585
80Morphine addiction_Homo sapiens_hsa050320.87028338
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86338426
82Lysine degradation_Homo sapiens_hsa003100.85765015
83Rheumatoid arthritis_Homo sapiens_hsa053230.82978869
84Apoptosis_Homo sapiens_hsa042100.82081636
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80492796
86Insulin resistance_Homo sapiens_hsa049310.77515970
87Type I diabetes mellitus_Homo sapiens_hsa049400.77208815
88Glycerolipid metabolism_Homo sapiens_hsa005610.76751506
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.74805803
90Chemokine signaling pathway_Homo sapiens_hsa040620.71886950
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.69406203
92Acute myeloid leukemia_Homo sapiens_hsa052210.68852089
93Steroid biosynthesis_Homo sapiens_hsa001000.67405815
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66666501
95Shigellosis_Homo sapiens_hsa051310.65904765
96Asthma_Homo sapiens_hsa053100.65572346
97Prion diseases_Homo sapiens_hsa050200.65135236
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65134051
99Arginine and proline metabolism_Homo sapiens_hsa003300.62556971
100Renin secretion_Homo sapiens_hsa049240.62020815
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59851714
102Nicotine addiction_Homo sapiens_hsa050330.58095267
103Gastric acid secretion_Homo sapiens_hsa049710.57605839
104Vitamin digestion and absorption_Homo sapiens_hsa049770.56141450
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.55815309
106Pertussis_Homo sapiens_hsa051330.54782779
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53136963
108Hepatitis C_Homo sapiens_hsa051600.52747379
109Toxoplasmosis_Homo sapiens_hsa051450.51051904
110Prolactin signaling pathway_Homo sapiens_hsa049170.49908783
111Ether lipid metabolism_Homo sapiens_hsa005650.48968501
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48947250
113Salivary secretion_Homo sapiens_hsa049700.48682849
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48506453
115Glucagon signaling pathway_Homo sapiens_hsa049220.45502566
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45049428
117Folate biosynthesis_Homo sapiens_hsa007900.44139178
118Taste transduction_Homo sapiens_hsa047420.43759598
119Sulfur relay system_Homo sapiens_hsa041220.42028742
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.40318379
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40227357
122AMPK signaling pathway_Homo sapiens_hsa041520.39723590
123African trypanosomiasis_Homo sapiens_hsa051430.37999778
124Renin-angiotensin system_Homo sapiens_hsa046140.37860392
125Legionellosis_Homo sapiens_hsa051340.37156184
126Serotonergic synapse_Homo sapiens_hsa047260.36940692
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36620697
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36013813
129Type II diabetes mellitus_Homo sapiens_hsa049300.33602977
130Oxytocin signaling pathway_Homo sapiens_hsa049210.33400996
131Insulin signaling pathway_Homo sapiens_hsa049100.33101630
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32707829
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32379890
134Amphetamine addiction_Homo sapiens_hsa050310.32367792
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31868813
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31422810
137Olfactory transduction_Homo sapiens_hsa047400.31362986
138Circadian entrainment_Homo sapiens_hsa047130.31348444
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31331252
140MAPK signaling pathway_Homo sapiens_hsa040100.31143435
141Vitamin B6 metabolism_Homo sapiens_hsa007500.30770909
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.29123005
143Amoebiasis_Homo sapiens_hsa051460.26682165
144Thyroid hormone synthesis_Homo sapiens_hsa049180.26464192
145Calcium signaling pathway_Homo sapiens_hsa040200.25562267
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.23965601
147Pentose phosphate pathway_Homo sapiens_hsa000300.23941401
148Endocytosis_Homo sapiens_hsa041440.23461863
149Ovarian steroidogenesis_Homo sapiens_hsa049130.23137790
150Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22579564
151Glutathione metabolism_Homo sapiens_hsa004800.22447726
152Dorso-ventral axis formation_Homo sapiens_hsa043200.21095253
153Lysosome_Homo sapiens_hsa041420.20602582
154* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19439449
155Central carbon metabolism in cancer_Homo sapiens_hsa052300.17922226
156Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17500352
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17273402
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.16057526
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14534410
160Focal adhesion_Homo sapiens_hsa045100.14079310
161Galactose metabolism_Homo sapiens_hsa000520.13899044
162Protein digestion and absorption_Homo sapiens_hsa049740.13414860
163Insulin secretion_Homo sapiens_hsa049110.10266118
164Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.10141535
165Metabolic pathways_Homo sapiens_hsa011000.09885648
166Dilated cardiomyopathy_Homo sapiens_hsa054140.09389707
167Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08197719
168ECM-receptor interaction_Homo sapiens_hsa045120.07829818
169Bladder cancer_Homo sapiens_hsa052190.07646020

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