AMH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1androgen biosynthetic process (GO:0006702)9.91554979
2Leydig cell differentiation (GO:0033327)9.02001794
3regulation of gonadotropin secretion (GO:0032276)8.52862224
4male sex determination (GO:0030238)7.41275619
5regulation of female gonad development (GO:2000194)7.21525014
6positive regulation of protein kinase C signaling (GO:0090037)6.38970467
7adrenal gland development (GO:0030325)5.85163798
8* sex differentiation (GO:0007548)5.68555461
9negative regulation of macrophage differentiation (GO:0045650)5.63352430
10ovulation cycle (GO:0042698)5.53975468
11cellular response to gonadotropin stimulus (GO:0071371)5.51610521
12cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.42137862
13protein heterotrimerization (GO:0070208)5.37474863
14glomerular basement membrane development (GO:0032836)5.32996128
15oocyte development (GO:0048599)5.25037473
16glucocorticoid biosynthetic process (GO:0006704)5.22325544
17male genitalia development (GO:0030539)5.12157910
18hemoglobin metabolic process (GO:0020027)5.08925778
19apoptotic cell clearance (GO:0043277)4.96181045
20androgen metabolic process (GO:0008209)4.95695735
21estrogen biosynthetic process (GO:0006703)4.95357411
22positive regulation of hormone biosynthetic process (GO:0046886)4.79967048
23progesterone metabolic process (GO:0042448)4.72769890
24negative regulation of T cell differentiation in thymus (GO:0033085)4.71848059
25positive regulation of reproductive process (GO:2000243)4.68393089
26embryonic foregut morphogenesis (GO:0048617)4.62943278
27regulation of meiosis I (GO:0060631)4.56342922
28basement membrane organization (GO:0071711)4.50793449
29peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.39807575
30vagina development (GO:0060068)4.21081770
31epithelial cell fate commitment (GO:0072148)4.19620106
32atrioventricular valve morphogenesis (GO:0003181)4.13859984
33melanin biosynthetic process (GO:0042438)4.11600675
34endocardial cushion development (GO:0003197)4.09062038
35regulation of cardioblast differentiation (GO:0051890)4.07259059
36diaphragm development (GO:0060539)4.05805593
37response to follicle-stimulating hormone (GO:0032354)4.04753192
38head development (GO:0060322)3.98414072
39genitalia development (GO:0048806)3.98370715
40* anatomical structure regression (GO:0060033)3.91916719
41response to gonadotropin (GO:0034698)3.91775551
42semaphorin-plexin signaling pathway (GO:0071526)3.87802256
43natural killer cell differentiation (GO:0001779)3.84601570
44UV protection (GO:0009650)3.83067103
45negative regulation of cell size (GO:0045792)3.82956057
46GDP-mannose metabolic process (GO:0019673)3.82442462
47response to insecticide (GO:0017085)3.81951316
48reproductive system development (GO:0061458)3.78047578
49DNA strand renaturation (GO:0000733)3.78010362
50skeletal muscle organ development (GO:0060538)3.74451686
51cellular response to interferon-alpha (GO:0035457)3.69713687
52cell-cell junction maintenance (GO:0045217)3.68870641
53meiotic chromosome segregation (GO:0045132)3.65776052
54melanin metabolic process (GO:0006582)3.64998540
55multicellular organismal aging (GO:0010259)3.64988945
56regulation of hydrogen peroxide metabolic process (GO:0010310)3.63667543
57response to methylmercury (GO:0051597)3.62742873
58maintenance of protein location in nucleus (GO:0051457)3.58627735
59nephron tubule formation (GO:0072079)3.58561952
60seminiferous tubule development (GO:0072520)3.56440750
61growth hormone secretion (GO:0030252)3.51883951
62glomerulus development (GO:0032835)3.51545610
63somite development (GO:0061053)3.48954138
64establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.47115955
65mitochondrion transport along microtubule (GO:0047497)3.47115955
66fusion of sperm to egg plasma membrane (GO:0007342)3.46851686
67cell migration in hindbrain (GO:0021535)3.46432979
68glucocorticoid metabolic process (GO:0008211)3.42292917
69secondary metabolite biosynthetic process (GO:0044550)3.38607417
70astrocyte development (GO:0014002)3.37885209
71cellular response to antibiotic (GO:0071236)3.37504314
72germ cell migration (GO:0008354)3.37112314
73female genitalia development (GO:0030540)3.36726855
74ketone biosynthetic process (GO:0042181)3.35640799
75planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34536767
76cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.34224987
77chondrocyte proliferation (GO:0035988)3.32978882
78regulation of protein kinase C signaling (GO:0090036)3.32390180
79epithelial cell-cell adhesion (GO:0090136)3.31573050
80positive regulation of hormone metabolic process (GO:0032352)3.30121024
81positive regulation of odontogenesis (GO:0042482)3.29797652
82negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.24925653
83hormone biosynthetic process (GO:0042446)3.24652080
84establishment of mitochondrion localization (GO:0051654)3.22480667
85regulation of ARF GTPase activity (GO:0032312)3.22477059
86regulation of steroid hormone biosynthetic process (GO:0090030)3.22310747
87cardiac myofibril assembly (GO:0055003)3.21362779
88positive regulation of synapse maturation (GO:0090129)3.18563714
89positive regulation of macrophage cytokine production (GO:0060907)3.17953371
90glomerular filtration (GO:0003094)3.16533356
91regulation of steroid biosynthetic process (GO:0050810)3.15742907
92male gonad development (GO:0008584)3.11577544
93endothelial cell chemotaxis (GO:0035767)3.10335818
94negative regulation of cell aging (GO:0090344)3.09660829
95histone H4 deacetylation (GO:0070933)3.05136788
96sensory perception of taste (GO:0050909)3.04496141
97stress granule assembly (GO:0034063)3.03000714
98DNA replication checkpoint (GO:0000076)3.01500282
99embryonic eye morphogenesis (GO:0048048)3.00626345
100adenine nucleotide transport (GO:0051503)2.99306470
101cellular response to ATP (GO:0071318)2.98017874
102mannose metabolic process (GO:0006013)2.96485153
103atrial septum morphogenesis (GO:0060413)2.96019151
104estrogen metabolic process (GO:0008210)2.95976949
105snRNA metabolic process (GO:0016073)2.95131560
106regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.94558809
107piRNA metabolic process (GO:0034587)2.92293102
108regulation of nuclear cell cycle DNA replication (GO:0033262)2.90148010
109cranial nerve morphogenesis (GO:0021602)2.88837061
110regulation of mammary gland epithelial cell proliferation (GO:0033599)2.88575019
111dermatan sulfate metabolic process (GO:0030205)2.88155090
112* ovulation cycle process (GO:0022602)2.86152985
113glial cell proliferation (GO:0014009)2.85948490
114C21-steroid hormone metabolic process (GO:0008207)2.84730457
115regulation of synapse structural plasticity (GO:0051823)2.84719636
116positive regulation of meiosis (GO:0045836)2.84468297
117histone H3 deacetylation (GO:0070932)2.81627380
118ovarian follicle development (GO:0001541)2.81464129
119snRNA processing (GO:0016180)2.81061007
120urinary tract smooth muscle contraction (GO:0014848)2.80448426
121cellular response to leptin stimulus (GO:0044320)2.80419651
122positive regulation of smoothened signaling pathway (GO:0045880)2.80249698
123renal filtration (GO:0097205)2.79983980
124convergent extension (GO:0060026)2.78638215
125proximal/distal pattern formation (GO:0009954)2.78062830
126cardiac muscle tissue development (GO:0048738)2.76776026
127negative regulation of catenin import into nucleus (GO:0035414)2.75782262
128ovulation (GO:0030728)2.74698080
129peripheral nervous system axon ensheathment (GO:0032292)2.73952598
130myelination in peripheral nervous system (GO:0022011)2.73952598
131regulation of chromatin binding (GO:0035561)2.72151895
132regulation of protein kinase A signaling (GO:0010738)2.71611637
133cardiac right ventricle morphogenesis (GO:0003215)2.71018487
134benzene-containing compound metabolic process (GO:0042537)2.70898072
135regulation of synapse maturation (GO:0090128)2.70582759
136adhesion of symbiont to host (GO:0044406)2.70562833
137synaptic vesicle docking involved in exocytosis (GO:0016081)2.69620217
138cell junction maintenance (GO:0034331)2.69478697
139midgut development (GO:0007494)2.68834981
140response to leptin (GO:0044321)2.68700991
141protein insertion into membrane (GO:0051205)2.68555854
142mesenchymal to epithelial transition (GO:0060231)2.68061943
143establishment of apical/basal cell polarity (GO:0035089)2.66735042
144negative regulation of meiosis (GO:0045835)2.66625906
145positive regulation of gastrulation (GO:2000543)2.65075291
146protein-DNA complex disassembly (GO:0032986)2.65022452
147nucleosome disassembly (GO:0006337)2.65022452
148collagen catabolic process (GO:0030574)2.64896615
149dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63189866
150response to nitrosative stress (GO:0051409)2.62822008
151receptor guanylyl cyclase signaling pathway (GO:0007168)2.62688869
152adenosine receptor signaling pathway (GO:0001973)2.61607347
153gastrulation with mouth forming second (GO:0001702)2.60516054
154collagen metabolic process (GO:0032963)2.57684568
155positive regulation of meiotic cell cycle (GO:0051446)2.55862765
156positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.55513189
157positive regulation of dendrite morphogenesis (GO:0050775)2.55321600
158metanephric mesenchyme development (GO:0072075)2.55145808
159regulation of hormone biosynthetic process (GO:0046885)2.55008646
160negative regulation of DNA-templated transcription, elongation (GO:0032785)2.52603118
161positive regulation of chondrocyte differentiation (GO:0032332)2.52513147
162response to parathyroid hormone (GO:0071107)2.52242434
163negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.51548312
164embryonic camera-type eye morphogenesis (GO:0048596)2.50368018
165behavioral response to nicotine (GO:0035095)2.48821548
166purine nucleotide transport (GO:0015865)2.48594336
167lymph vessel development (GO:0001945)2.47200710
168nephron tubule morphogenesis (GO:0072078)2.47197643
169nephron epithelium morphogenesis (GO:0072088)2.47197643
170detection of temperature stimulus involved in sensory perception (GO:0050961)2.46002966
171detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.46002966
172heterochromatin organization (GO:0070828)2.44036479
173regulation of skeletal muscle contraction (GO:0014819)2.43601394
174establishment of monopolar cell polarity (GO:0061162)2.42900023
175establishment or maintenance of monopolar cell polarity (GO:0061339)2.42900023
176mRNA cleavage (GO:0006379)2.41819244
177bone development (GO:0060348)2.41744840
178regulation of translational fidelity (GO:0006450)2.39314060
179ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.38921507
180positive regulation of male gonad development (GO:2000020)13.8047916
181regulation of male gonad development (GO:2000018)12.2760585
182* sex determination (GO:0007530)11.0551869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human6.34217482
2IKZF1_21737484_ChIP-ChIP_HCT116_Human4.00889910
3CLOCK_20551151_ChIP-Seq_293T_Human3.21337553
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.19944093
5WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.95873098
6* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.69131370
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.65581371
8ZNF263_19887448_ChIP-Seq_K562_Human2.62852649
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.53153170
10P68_20966046_ChIP-Seq_HELA_Human2.48303120
11KDM2B_26808549_Chip-Seq_DND41_Human2.46886073
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43915593
13KDM2B_26808549_Chip-Seq_K562_Human2.35634542
14TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.33999461
15DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.32532462
16* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17036739
17TCF7_22412390_ChIP-Seq_EML_Mouse2.08092453
18TET1_21451524_ChIP-Seq_MESCs_Mouse2.05556661
19* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.02532703
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.00222922
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98865336
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.94831212
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94408227
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94408227
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94408227
26LXR_22292898_ChIP-Seq_THP-1_Human1.92487720
27XRN2_22483619_ChIP-Seq_HELA_Human1.88679953
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.86773633
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84940096
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83328053
31SMC4_20622854_ChIP-Seq_HELA_Human1.79665923
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.79364108
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78320843
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.76287719
35* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.76161814
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.74575675
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.73094039
38RACK7_27058665_Chip-Seq_MCF-7_Human1.72378243
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72199610
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72199610
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70840915
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.70412405
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.68754597
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.68548782
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.65476188
46* CREB1_26743006_Chip-Seq_LNCaP_Human1.64951526
47* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64734546
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.64399900
49BCL6_27268052_Chip-Seq_Bcells_Human1.63884307
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61908618
51MYC_22102868_ChIP-Seq_BL_Human1.61160127
52PHF8_20622854_ChIP-Seq_HELA_Human1.60837180
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.60147714
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60105122
55* FOXP1_21924763_ChIP-Seq_HESCs_Human1.58670122
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.58579862
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.58491003
58TP53_22127205_ChIP-Seq_IMR90_Human1.58341609
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57763304
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57719383
61EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56414364
62E2F1_20622854_ChIP-Seq_HELA_Human1.55643338
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.54964331
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.54045833
65ISL1_27105846_Chip-Seq_CPCs_Mouse1.52938809
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52091508
67BCOR_27268052_Chip-Seq_Bcells_Human1.50437374
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50218988
69* RARA_24833708_ChIP-Seq_LIVER_Mouse1.47964929
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47591840
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47374594
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.44630733
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44543667
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43022079
75NCOR1_26117541_ChIP-Seq_K562_Human1.39927572
76* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39769641
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.39361408
78* RARB_24833708_ChIP-Seq_LIVER_Mouse1.39204551
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36625258
80MAF_26560356_Chip-Seq_TH2_Human1.35329048
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34970520
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34811386
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33698048
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33592109
85* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32547702
86VDR_21846776_ChIP-Seq_THP-1_Human1.31751642
87TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.31064280
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30299613
89TP53_16413492_ChIP-PET_HCT116_Human1.29784353
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29594914
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28828052
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.28263223
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27511757
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.26802006
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26342253
96TBX20_22328084_ChIP-Seq_HEART_Mouse1.26221442
97TBX20_22080862_ChIP-Seq_HEART_Mouse1.26221442
98MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22948426
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22518456
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21994482
101GABP_19822575_ChIP-Seq_HepG2_Human1.21472251
102STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.20988425
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.20337843
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20288953
105CTCF_21964334_Chip-Seq_Bcells_Human1.19864293
106KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18675691
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18207382
108EZH2_27304074_Chip-Seq_ESCs_Mouse1.18097185
109TP63_19390658_ChIP-ChIP_HaCaT_Human1.17982195
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17910976
111SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16385405
112DROSHA_22980978_ChIP-Seq_HELA_Human1.16353566
113CHD1_26751641_Chip-Seq_LNCaP_Human1.15181173
114E2F7_22180533_ChIP-Seq_HELA_Human1.14468054
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13935204
116* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13825534
117* CTCF_26484167_Chip-Seq_Bcells_Mouse1.13489525
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12707749
119ATF3_27146783_Chip-Seq_COLON_Human1.12395847
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12124833
121JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11916153
122ESR1_21235772_ChIP-Seq_MCF-7_Human1.11486499
123TP63_22573176_ChIP-Seq_HFKS_Human1.11191838
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11032829
125GATA1_19941826_ChIP-Seq_K562_Human1.09672138
126* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09434156
127CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08847257
128JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07178758
129SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06421505
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06014061
131SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05533207
132OCT4_19829295_ChIP-Seq_ESCs_Human1.05400520
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05347244
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05340527
135CTCF_20526341_ChIP-Seq_ESCs_Human1.05318895
136TP53_20018659_ChIP-ChIP_R1E_Mouse1.05182987
137EED_16625203_ChIP-ChIP_MESCs_Mouse1.03823713
138YY1_22570637_ChIP-Seq_MALME-3M_Human1.03750644
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03089926
140CTCF_27219007_Chip-Seq_Bcells_Human1.03013850
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02458355
142IGF1R_20145208_ChIP-Seq_DFB_Human1.02280155
143SA1_27219007_Chip-Seq_Bcells_Human1.01823701
144SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01023598
145TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99799883
146KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99778937
147OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96907892
148EP300_21415370_ChIP-Seq_HL-1_Mouse0.93756148
149RING1B_27294783_Chip-Seq_ESCs_Mouse0.93612127
150NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92759341
151SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91384866
152RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91058868
153SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.90816530
154SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89711836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence8.39612671
2MP0003136_yellow_coat_color4.87485521
3MP0005409_darkened_coat_color3.82628203
4MP0003195_calcinosis3.63383344
5MP0001188_hyperpigmentation3.60245806
6MP0009384_cardiac_valve_regurgitation3.38171306
7MP0005377_hearing/vestibular/ear_phenot3.31641661
8MP0003878_abnormal_ear_physiology3.31641661
9MP0001958_emphysema3.28825773
10MP0005623_abnormal_meninges_morphology3.26992033
11MP0001661_extended_life_span3.25959032
12MP0003315_abnormal_perineum_morphology3.06571365
13MP0008438_abnormal_cutaneous_collagen3.00405650
14MP0004272_abnormal_basement_membrane2.93771086
15MP0008877_abnormal_DNA_methylation2.75113633
16MP0003045_fibrosis2.74370141
17MP0003786_premature_aging2.74168551
18MP0002249_abnormal_larynx_morphology2.69382757
19MP0005423_abnormal_somatic_nervous2.66809237
20MP0000751_myopathy2.45987238
21MP0005174_abnormal_tail_pigmentation2.40684773
22MP0003115_abnormal_respiratory_system2.33133736
23MP0000678_abnormal_parathyroid_gland2.32903738
24MP0000013_abnormal_adipose_tissue2.30744454
25MP0009278_abnormal_bone_marrow2.23471314
26MP0003123_paternal_imprinting2.12029394
27MP0005503_abnormal_tendon_morphology2.08132762
28MP0005647_abnormal_sex_gland2.04768976
29MP0002160_abnormal_reproductive_system1.96938816
30MP0002168_other_aberrant_phenotype1.93394844
31MP0000003_abnormal_adipose_tissue1.92696074
32MP0003705_abnormal_hypodermis_morpholog1.83509358
33MP0003122_maternal_imprinting1.77761175
34MP0000639_abnormal_adrenal_gland1.72535971
35MP0002822_catalepsy1.72372579
36MP0001986_abnormal_taste_sensitivity1.71173404
37MP0001502_abnormal_circadian_rhythm1.70616234
38MP0006054_spinal_hemorrhage1.57661357
39MP0003936_abnormal_reproductive_system1.57544607
40MP0006292_abnormal_olfactory_placode1.53555820
41* MP0002210_abnormal_sex_determination1.52976355
42MP0004381_abnormal_hair_follicle1.51115748
43MP0009379_abnormal_foot_pigmentation1.50358149
44MP0010030_abnormal_orbit_morphology1.46466617
45MP0005076_abnormal_cell_differentiation1.45062224
46MP0000049_abnormal_middle_ear1.42738194
47* MP0001145_abnormal_male_reproductive1.42565472
48MP0005389_reproductive_system_phenotype1.39836962
49MP0003111_abnormal_nucleus_morphology1.39773125
50MP0006138_congestive_heart_failure1.38829797
51MP0001849_ear_inflammation1.36932277
52MP0001968_abnormal_touch/_nociception1.35990074
53MP0003119_abnormal_digestive_system1.34496564
54MP0003879_abnormal_hair_cell1.34295463
55MP0000428_abnormal_craniofacial_morphol1.32561599
56MP0003567_abnormal_fetal_cardiomyocyte1.30425728
57MP0003942_abnormal_urinary_system1.28219171
58MP0003385_abnormal_body_wall1.27037207
59MP0009250_abnormal_appendicular_skeleto1.26056220
60MP0009780_abnormal_chondrocyte_physiolo1.22959896
61MP0004084_abnormal_cardiac_muscle1.22623351
62MP0000653_abnormal_sex_gland1.18056074
63MP0000538_abnormal_urinary_bladder1.17572328
64MP0000462_abnormal_digestive_system1.16375598
65MP0001929_abnormal_gametogenesis1.15583078
66MP0001348_abnormal_lacrimal_gland1.11260682
67MP0000015_abnormal_ear_pigmentation1.11077277
68MP0005248_abnormal_Harderian_gland1.10389130
69MP0004147_increased_porphyrin_level1.10100933
70MP0000778_abnormal_nervous_system1.09257493
71MP0005171_absent_coat_pigmentation1.08720479
72MP0003091_abnormal_cell_migration1.07648395
73MP0001727_abnormal_embryo_implantation1.05265350
74MP0009053_abnormal_anal_canal1.04648124
75MP0003121_genomic_imprinting1.03976710
76MP0003283_abnormal_digestive_organ1.02268465
77MP0004858_abnormal_nervous_system1.01946349
78MP0005058_abnormal_lysosome_morphology1.01618501
79MP0002116_abnormal_craniofacial_bone1.01292928
80MP0003693_abnormal_embryo_hatching0.99201356
81MP0004134_abnormal_chest_morphology0.98514420
82MP0003300_gastrointestinal_ulcer0.98483303
83MP0005083_abnormal_biliary_tract0.96863935
84MP0000534_abnormal_ureter_morphology0.96423200
85MP0000537_abnormal_urethra_morphology0.95697569
86MP0005375_adipose_tissue_phenotype0.95530931
87MP0008875_abnormal_xenobiotic_pharmacok0.93704322
88MP0004233_abnormal_muscle_weight0.93160607
89MP0002114_abnormal_axial_skeleton0.92513495
90MP0000750_abnormal_muscle_regeneration0.91829479
91MP0004197_abnormal_fetal_growth/weight/0.91615376
92MP0000631_abnormal_neuroendocrine_gland0.90766315
93MP0005395_other_phenotype0.90605517
94MP0002234_abnormal_pharynx_morphology0.90119318
95MP0002896_abnormal_bone_mineralization0.89606325
96MP0002751_abnormal_autonomic_nervous0.89075865
97MP0001270_distended_abdomen0.86999764
98MP0003861_abnormal_nervous_system0.86803199
99MP0003941_abnormal_skin_development0.86097433
100MP0002697_abnormal_eye_size0.85144311
101MP0003698_abnormal_male_reproductive0.84832224
102MP0002102_abnormal_ear_morphology0.83045615
103MP0003755_abnormal_palate_morphology0.82593192
104MP0005257_abnormal_intraocular_pressure0.81849569
105MP0004859_abnormal_synaptic_plasticity0.80592212
106MP0004145_abnormal_muscle_electrophysio0.79486308
107MP0005670_abnormal_white_adipose0.79151277
108MP0002108_abnormal_muscle_morphology0.78110708
109MP0002128_abnormal_blood_circulation0.77934887
110MP0005394_taste/olfaction_phenotype0.76882761
111MP0005499_abnormal_olfactory_system0.76882761
112MP0004185_abnormal_adipocyte_glucose0.74964021
113MP0002282_abnormal_trachea_morphology0.73765162
114MP0002127_abnormal_cardiovascular_syste0.73746724
115MP0006276_abnormal_autonomic_nervous0.71847947
116MP0003935_abnormal_craniofacial_develop0.71148890
117MP0001119_abnormal_female_reproductive0.71076393
118MP0000566_synostosis0.70491713
119MP0000026_abnormal_inner_ear0.68504085
120MP0004133_heterotaxia0.68485163
121MP0001299_abnormal_eye_distance/0.68041544
122MP0010094_abnormal_chromosome_stability0.67695768
123MP0000467_abnormal_esophagus_morphology0.67035583
124MP0008789_abnormal_olfactory_epithelium0.66426358
125MP0002932_abnormal_joint_morphology0.65795866
126MP0005666_abnormal_adipose_tissue0.65337223
127MP0004043_abnormal_pH_regulation0.64616781
128MP0004036_abnormal_muscle_relaxation0.64506804
129MP0008932_abnormal_embryonic_tissue0.64319905
130MP0000733_abnormal_muscle_development0.64126197
131MP0001851_eye_inflammation0.63479601
132MP0005408_hypopigmentation0.63476056
133MP0003937_abnormal_limbs/digits/tail_de0.63244822
134MP0002075_abnormal_coat/hair_pigmentati0.62974140
135MP0002177_abnormal_outer_ear0.62856984
136MP0001340_abnormal_eyelid_morphology0.62823671
137MP0000569_abnormal_digit_pigmentation0.62751110
138MP0009672_abnormal_birth_weight0.62352382
139MP0002184_abnormal_innervation0.62273119
140MP0003137_abnormal_impulse_conducting0.62088994
141MP0005508_abnormal_skeleton_morphology0.61639269
142MP0002081_perinatal_lethality0.61518290
143MP0002111_abnormal_tail_morphology0.61314120
144MP0003632_abnormal_nervous_system0.60790784
145MP0000767_abnormal_smooth_muscle0.59786431
146MP0002084_abnormal_developmental_patter0.59276505
147MP0000470_abnormal_stomach_morphology0.56821434
148MP0002139_abnormal_hepatobiliary_system0.56348028
149MP0001919_abnormal_reproductive_system0.55586268
150MP0003279_aneurysm0.54671976
151MP0001730_embryonic_growth_arrest0.54408690
152MP0002115_abnormal_skeleton_extremities0.54069464
153MP0003866_abnormal_defecation0.53280962
154MP0002938_white_spotting0.51365079
155MP0002106_abnormal_muscle_physiology0.51005139
156MP0005275_abnormal_skin_tensile0.50841732
157MP0001440_abnormal_grooming_behavior0.50324578
158MP0002090_abnormal_vision0.49397580
159MP0002092_abnormal_eye_morphology0.49164254
160MP0003221_abnormal_cardiomyocyte_apopto0.48877577
161MP0002233_abnormal_nose_morphology0.48172163
162MP0002089_abnormal_postnatal_growth/wei0.47820811

Predicted human phenotypes

RankGene SetZ-score
1Abnormal sex determination (HP:0012244)7.55638996
2Sex reversal (HP:0012245)7.55638996
3Testicular neoplasm (HP:0010788)7.44823837
4* Male pseudohermaphroditism (HP:0000037)6.34720796
5Ankle contracture (HP:0006466)6.17450695
6Gonadotropin excess (HP:0000837)5.11200018
7Protrusio acetabuli (HP:0003179)4.55282780
8Azoospermia (HP:0000027)4.52235284
9Hypoplasia of the uterus (HP:0000013)4.36070363
10Germ cell neoplasia (HP:0100728)4.32620338
11Ulnar bowing (HP:0003031)4.32004305
12Abnormality of the phalanges of the hallux (HP:0010057)4.24564461
13Rectal prolapse (HP:0002035)4.01992303
14Secondary amenorrhea (HP:0000869)4.00121690
15Testicular atrophy (HP:0000029)3.96947284
16Bladder diverticulum (HP:0000015)3.86801874
17Rib fusion (HP:0000902)3.85878300
18Follicular hyperkeratosis (HP:0007502)3.72559761
19Turricephaly (HP:0000262)3.66232969
20Hypoventilation (HP:0002791)3.33080512
21Hypoplastic left heart (HP:0004383)3.31197117
22Type 1 muscle fiber predominance (HP:0003803)3.28535949
23Abnormal spermatogenesis (HP:0008669)3.21550132
24Premature ovarian failure (HP:0008209)3.19347834
25Aplasia/hypoplasia of the uterus (HP:0008684)3.14653415
26Slender build (HP:0001533)3.09030319
27Abnormality of the distal phalanx of the thumb (HP:0009617)3.08008867
28Facial hemangioma (HP:0000329)3.07472540
29Cerebral aneurysm (HP:0004944)3.00873706
30* Male infertility (HP:0003251)2.97937856
31Intestinal fistula (HP:0100819)2.97376310
32Renal duplication (HP:0000075)2.96754180
33Renovascular hypertension (HP:0100817)2.93466860
34Patellar aplasia (HP:0006443)2.91197850
35Vaginal fistula (HP:0004320)2.90579291
36Primary amenorrhea (HP:0000786)2.90441953
37Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.88577904
38Nausea (HP:0002018)2.83262228
39Increased variability in muscle fiber diameter (HP:0003557)2.81808633
40Mesangial abnormality (HP:0001966)2.81798185
41Broad face (HP:0000283)2.79918293
42Premature rupture of membranes (HP:0001788)2.79400212
43Poikiloderma (HP:0001029)2.79039952
44Rectovaginal fistula (HP:0000143)2.78973234
45Rectal fistula (HP:0100590)2.78973234
46* Abnormality of male internal genitalia (HP:0000022)2.78024959
47Pulmonary fibrosis (HP:0002206)2.78002932
48Abnormality of the 1st metacarpal (HP:0010009)2.70812428
49Aplasia/Hypoplasia of the patella (HP:0006498)2.70795885
50Abnormality of the proximal phalanges of the hand (HP:0009834)2.67712516
51Hyperacusis (HP:0010780)2.63986996
52Annular pancreas (HP:0001734)2.61048089
53Short humerus (HP:0005792)2.56804408
54Broad palm (HP:0001169)2.55670858
55Arachnodactyly (HP:0001166)2.55577057
56Bowing of the arm (HP:0006488)2.55561314
57Bowed forearm bones (HP:0003956)2.55561314
58Short femoral neck (HP:0100864)2.55276626
59Flared iliac wings (HP:0002869)2.52898687
60Cupped ribs (HP:0000887)2.52621112
61Coronal craniosynostosis (HP:0004440)2.52293303
62Biconcave vertebral bodies (HP:0004586)2.48455533
63Hand muscle atrophy (HP:0009130)2.48166027
64Limb-girdle muscle weakness (HP:0003325)2.46537149
65Short 4th metacarpal (HP:0010044)2.45770165
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.45770165
67Lymphangioma (HP:0100764)2.42343071
68Ovarian neoplasm (HP:0100615)2.41695301
69Abnormality of skeletal muscle fiber size (HP:0012084)2.38798412
70J-shaped sella turcica (HP:0002680)2.37772908
71Hypoplastic heart (HP:0001961)2.36371410
72Aplasia/hypoplasia of the humerus (HP:0006507)2.34069032
73Insomnia (HP:0100785)2.31302398
74Myopathic facies (HP:0002058)2.31283534
75Aortic dissection (HP:0002647)2.28976984
76Cervical subluxation (HP:0003308)2.27921224
77Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.26900989
78Joint stiffness (HP:0001387)2.25921869
79Obstructive sleep apnea (HP:0002870)2.24723569
80Mildly elevated creatine phosphokinase (HP:0008180)2.24325481
81Abnormality of the femoral head (HP:0003368)2.23216610
82Abnormality of femoral epiphyses (HP:0006499)2.23143422
83Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.23143422
84Polycystic ovaries (HP:0000147)2.23140712
85Abnormal ventriculo-arterial connection (HP:0011563)2.22668153
86Transposition of the great arteries (HP:0001669)2.22668153
87Abnormal connection of the cardiac segments (HP:0011545)2.22668153
88Selective tooth agenesis (HP:0001592)2.21203974
89Short thumb (HP:0009778)2.20157288
90Slender long bone (HP:0003100)2.19809141
91Metaphyseal cupping (HP:0003021)2.19716564
92Breast hypoplasia (HP:0003187)2.18305242
93Hypoplasia of the radius (HP:0002984)2.18167594
94Abnormality of the 4th metacarpal (HP:0010012)2.17280960
95Abnormality of the aortic arch (HP:0012303)2.17008263
96Distal upper limb amyotrophy (HP:0007149)2.16968908
97Upper limb amyotrophy (HP:0009129)2.16968908
98Abnormality of the 2nd finger (HP:0004100)2.16640679
99Stridor (HP:0010307)2.15578742
100Short phalanx of the thumb (HP:0009660)2.12805881
101Elfin facies (HP:0004428)2.12702530
102Thin ribs (HP:0000883)2.11415798
103Overriding aorta (HP:0002623)2.10637790
104Pulmonary artery stenosis (HP:0004415)2.09865388
105Atelectasis (HP:0100750)2.08554201
106Aplasia/hypoplasia of the femur (HP:0005613)2.07509419
107Broad metatarsal (HP:0001783)2.07071090
108Shallow orbits (HP:0000586)2.06970943
109* Infertility (HP:0000789)2.06765171
110Lumbar hyperlordosis (HP:0002938)2.05706547
111Hypoplasia of the ulna (HP:0003022)2.05667824
112Spinal rigidity (HP:0003306)2.05113126
113Pointed chin (HP:0000307)2.04709682
114Capillary hemangiomas (HP:0005306)2.04587844
115Delayed epiphyseal ossification (HP:0002663)2.04393591
116Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03686745
117Soft skin (HP:0000977)2.03500002
118Squamous cell carcinoma (HP:0002860)2.03002679
119Abnormality of dentin (HP:0010299)2.02751675
120Flat cornea (HP:0007720)2.02751343
121Gynecomastia (HP:0000771)2.02335957
122Female pseudohermaphroditism (HP:0010458)2.00583131
123Absent epiphyses (HP:0010577)2.00116316
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.00116316
125Gonadal dysgenesis (HP:0000133)11.2173286
126Abnormality of the epiphysis of the femoral head (HP:0010574)1.98406908
127Bronchomalacia (HP:0002780)1.97165445
128Thin bony cortex (HP:0002753)1.97153857
129Myotonia (HP:0002486)1.96372883
130Tongue fasciculations (HP:0001308)1.94485180
131Neonatal short-limb short stature (HP:0008921)1.93512007
132Nuclear cataract (HP:0100018)1.92465700
133Ependymoma (HP:0002888)1.91621731
134Abnormality of the middle phalanges of the toes (HP:0010183)1.91556542
135Increased connective tissue (HP:0009025)1.91265583
136Mitral valve prolapse (HP:0001634)1.91250278
137Tibial bowing (HP:0002982)1.91239603
138Broad distal phalanx of finger (HP:0009836)1.90712062
139Abnormality of the lower motor neuron (HP:0002366)1.90636111
140Hypokalemic alkalosis (HP:0001949)1.90617146
141Sprengel anomaly (HP:0000912)1.90353311
142Primary adrenal insufficiency (HP:0008207)1.89917756
143Abnormality of the peritoneum (HP:0002585)1.89441813
144Coxa vara (HP:0002812)1.88437420
145Joint laxity (HP:0001388)1.88301433
146Narrow nasal bridge (HP:0000446)1.87460706
147Relative macrocephaly (HP:0004482)1.87055493
148Wrist flexion contracture (HP:0001239)1.86052918
149Fragile skin (HP:0001030)1.85902452
150Bowel diverticulosis (HP:0005222)1.85369741
151Patent foramen ovale (HP:0001655)1.84033548
152Atrophic scars (HP:0001075)1.82634348
153Muscle fibrillation (HP:0010546)1.82466502
154Optic nerve coloboma (HP:0000588)1.82262968
155Aortic aneurysm (HP:0004942)1.79637328
156Vertebral clefting (HP:0008428)1.78496006
157Facial diplegia (HP:0001349)1.76966852
158High anterior hairline (HP:0009890)1.76234785
159Vitreoretinal degeneration (HP:0000655)1.76075022
160Ankle clonus (HP:0011448)1.75767033
161Wide anterior fontanel (HP:0000260)1.75447808
162Proximal placement of thumb (HP:0009623)1.74679485
163Protruding ear (HP:0000411)1.73861312
164Anteriorly placed anus (HP:0001545)1.73034986
165Neoplasm of the heart (HP:0100544)1.72391724
166Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72352425
167Broad alveolar ridges (HP:0000187)1.72016781
168Mitral regurgitation (HP:0001653)1.69485202
169Blue sclerae (HP:0000592)1.69232411
170Shawl scrotum (HP:0000049)1.68713332
171Retinal dysplasia (HP:0007973)1.68314072
172Broad forehead (HP:0000337)1.67958759
173Midline defect of the nose (HP:0004122)1.67537846
174Birth length less than 3rd percentile (HP:0003561)1.65952704
175Astrocytoma (HP:0009592)1.64297825
176Abnormality of the astrocytes (HP:0100707)1.64297825
177Long eyelashes (HP:0000527)1.64091948
178Aplasia/Hypoplasia of the ulna (HP:0006495)1.64028540
179Short thorax (HP:0010306)1.62962340
180Complete atrioventricular canal defect (HP:0001674)1.60126808

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYRO35.76711996
2TRIB35.14238011
3RIPK13.42794413
4CDK123.34652596
5PDGFRA3.21494320
6LATS12.97883337
7MAPK152.91388988
8CDK72.90822460
9PKN22.74372104
10PTK62.74295949
11PRPF4B2.42278266
12DAPK22.37865134
13ICK2.35953355
14EEF2K2.15018160
15MAP2K62.14492542
16MAP3K102.10351030
17SMG12.03122062
18PRKD31.95954055
19CDK41.82523929
20MAP2K31.79827199
21BRD41.63009666
22LATS21.60272507
23MARK21.59694249
24KDR1.57050094
25TAOK21.55435711
26MAP3K41.53632356
27TTN1.53451574
28MUSK1.52389976
29EPHB21.49537658
30MYLK1.38689187
31MST1R1.37547231
32PAK41.36441955
33RPS6KL11.34447079
34RPS6KC11.34447079
35RPS6KA61.22703968
36WNK31.18495765
37INSRR1.15425157
38PAK21.14642991
39WNK11.10415937
40ERN11.09886782
41PDGFRB1.09159873
42MAP3K61.08412244
43LMTK21.07897994
44CSNK1A1L1.07038598
45PASK1.06212470
46STK31.03833642
47NME10.99423071
48MTOR0.97630633
49CDK90.97601295
50MAP2K20.95719347
51CAMK1D0.94924532
52MAP3K70.94893680
53PTK20.91428758
54DDR20.89252368
55MAP3K110.89194253
56FGFR10.89178919
57SCYL20.86870209
58CDK80.86103429
59EPHA20.85286842
60CDK11A0.85221002
61DAPK30.85017125
62FGFR40.84464237
63TGFBR10.83161084
64BMX0.82965237
65CDK150.81110538
66CDC42BPA0.80590374
67CAMK1G0.79305848
68PRKCI0.79246307
69ATR0.79145018
70CHEK20.78808761
71IRAK30.78806693
72DAPK10.77918217
73TLK10.77842454
74LRRK20.77395480
75EPHB10.77267748
76PTK2B0.76862823
77FER0.74101273
78PAK30.73352809
79WNK40.72801758
80KSR20.72209235
81MAPK120.71917772
82CDK180.71391241
83RET0.70580078
84MET0.69907847
85DMPK0.68558471
86MKNK10.67399887
87NEK20.67375597
88MARK10.66970754
89ILK0.66814812
90DYRK1B0.66334444
91TNK20.66066410
92CAMKK10.65557293
93AURKA0.64619093
94DYRK20.63385855
95MAPK80.61939367
96PDPK10.60853563
97CDK20.58732590
98PRKAA10.57838798
99RPS6KB20.57495354
100IRAK20.54745441
101CDK30.54175551
102RPS6KA10.53624690
103CDC70.53297635
104CDK140.53050097
105LIMK10.52056157
106STK110.51163664
107STK40.49853988
108NME20.49667232
109BRAF0.49064696
110GRK60.48993574
111MAPK10.48863136
112PRKCH0.48709422
113STK160.48206498
114NTRK10.47557656
115MAP3K20.46423911
116STK38L0.45746350
117MAPK110.45575098
118CLK10.45361567
119PAK10.45174696
120PRKD20.44143130
121FGFR20.43937324
122AKT20.43431167
123ALK0.43322694
124NTRK20.41896210
125AKT10.41638903
126MAPK30.41533204
127MINK10.41528125
128PRKD10.39886927
129RPS6KA50.38744690
130ROCK20.38558957
131PAK60.38384507
132ERBB20.37942501
133CSNK1G30.37708170
134ROCK10.37043961
135CSNK1G10.35074786
136SIK20.34933669
137CHUK0.33475682
138SIK10.33161531
139CSNK1G20.33067929
140MKNK20.33013301
141PRKACB0.32742331
142CDK10.32685626
143RPS6KA20.30974355
144GSK3B0.30848268
145NTRK30.30352210
146MAP2K40.29919337
147WEE10.29720981
148MAPK140.29102965
149MAP2K10.29013273
150PRKDC0.27515560
151EGFR0.27179153
152SRC0.26350811
153CHEK10.25613969
154CAMK40.25558913

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001404.85801663
2Sulfur relay system_Homo sapiens_hsa041224.67089778
3Ovarian steroidogenesis_Homo sapiens_hsa049134.29543228
4Hedgehog signaling pathway_Homo sapiens_hsa043403.76999257
5ECM-receptor interaction_Homo sapiens_hsa045123.31514460
6Protein digestion and absorption_Homo sapiens_hsa049742.32194806
7Basal cell carcinoma_Homo sapiens_hsa052172.25092900
8Fatty acid biosynthesis_Homo sapiens_hsa000612.15373997
9Amoebiasis_Homo sapiens_hsa051462.13788215
10Fructose and mannose metabolism_Homo sapiens_hsa000512.06226073
11Focal adhesion_Homo sapiens_hsa045102.04662072
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.99148348
13Fatty acid metabolism_Homo sapiens_hsa012121.97749487
14Small cell lung cancer_Homo sapiens_hsa052221.96208010
15Lysine degradation_Homo sapiens_hsa003101.86021425
16Base excision repair_Homo sapiens_hsa034101.83980783
17Fanconi anemia pathway_Homo sapiens_hsa034601.79863393
18Other glycan degradation_Homo sapiens_hsa005111.78836617
19Axon guidance_Homo sapiens_hsa043601.76607839
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70483499
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62236765
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.61563989
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51184814
24* TGF-beta signaling pathway_Homo sapiens_hsa043501.49674906
25Notch signaling pathway_Homo sapiens_hsa043301.44592410
26Renin secretion_Homo sapiens_hsa049241.44139727
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42389833
28Steroid biosynthesis_Homo sapiens_hsa001001.32417791
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.32038602
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30288972
31Fatty acid degradation_Homo sapiens_hsa000711.30049622
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29855091
33Proteoglycans in cancer_Homo sapiens_hsa052051.29527851
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25209653
35Viral myocarditis_Homo sapiens_hsa054161.23613941
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19900085
37Bladder cancer_Homo sapiens_hsa052191.19064546
38Dorso-ventral axis formation_Homo sapiens_hsa043201.16865028
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16692418
40DNA replication_Homo sapiens_hsa030301.16483099
41Fatty acid elongation_Homo sapiens_hsa000621.15646561
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11167482
43Prolactin signaling pathway_Homo sapiens_hsa049171.09459801
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08568435
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07438686
46* Hippo signaling pathway_Homo sapiens_hsa043901.06760894
47Homologous recombination_Homo sapiens_hsa034401.05776449
48Toxoplasmosis_Homo sapiens_hsa051451.01998020
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.01520606
50Estrogen signaling pathway_Homo sapiens_hsa049151.00020891
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.99122953
52* cAMP signaling pathway_Homo sapiens_hsa040240.98929207
53ABC transporters_Homo sapiens_hsa020100.98521403
54PPAR signaling pathway_Homo sapiens_hsa033200.98043430
55Pathways in cancer_Homo sapiens_hsa052000.95492035
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95255612
57Vitamin digestion and absorption_Homo sapiens_hsa049770.92584624
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88872835
59Melanogenesis_Homo sapiens_hsa049160.88842640
60Insulin resistance_Homo sapiens_hsa049310.87431424
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86440072
62Cell cycle_Homo sapiens_hsa041100.85864333
63Choline metabolism in cancer_Homo sapiens_hsa052310.84075233
64Glioma_Homo sapiens_hsa052140.83687333
65Tight junction_Homo sapiens_hsa045300.82566627
66Insulin signaling pathway_Homo sapiens_hsa049100.82315663
67Nicotine addiction_Homo sapiens_hsa050330.81593089
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81013022
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80538133
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80316633
71Complement and coagulation cascades_Homo sapiens_hsa046100.79898902
72Dilated cardiomyopathy_Homo sapiens_hsa054140.79020371
73Adherens junction_Homo sapiens_hsa045200.78462720
74VEGF signaling pathway_Homo sapiens_hsa043700.77315633
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77221996
76Bile secretion_Homo sapiens_hsa049760.74397745
77Wnt signaling pathway_Homo sapiens_hsa043100.74335233
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.73261605
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.72845258
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.72436888
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71720281
82Gap junction_Homo sapiens_hsa045400.71449657
83mRNA surveillance pathway_Homo sapiens_hsa030150.70679426
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70023494
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69609885
86HTLV-I infection_Homo sapiens_hsa051660.69486095
87Gastric acid secretion_Homo sapiens_hsa049710.69373097
88Chronic myeloid leukemia_Homo sapiens_hsa052200.68301821
89Pyruvate metabolism_Homo sapiens_hsa006200.68055460
90Platelet activation_Homo sapiens_hsa046110.67035499
91Cholinergic synapse_Homo sapiens_hsa047250.66427880
92Taste transduction_Homo sapiens_hsa047420.65991010
93mTOR signaling pathway_Homo sapiens_hsa041500.65915745
94Prostate cancer_Homo sapiens_hsa052150.65732708
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.64918382
96Biosynthesis of amino acids_Homo sapiens_hsa012300.62407420
97Endometrial cancer_Homo sapiens_hsa052130.61522554
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60506737
99Alcoholism_Homo sapiens_hsa050340.58819148
100Colorectal cancer_Homo sapiens_hsa052100.57996419
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.57518723
102Oxytocin signaling pathway_Homo sapiens_hsa049210.57129336
103Inositol phosphate metabolism_Homo sapiens_hsa005620.56203296
104MAPK signaling pathway_Homo sapiens_hsa040100.55854793
105MicroRNAs in cancer_Homo sapiens_hsa052060.55530094
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55371641
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55371146
108Pyrimidine metabolism_Homo sapiens_hsa002400.54232697
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53270284
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52754839
111Non-small cell lung cancer_Homo sapiens_hsa052230.52463873
112RNA transport_Homo sapiens_hsa030130.52341170
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51099169
114Thyroid hormone synthesis_Homo sapiens_hsa049180.50833684
115Rap1 signaling pathway_Homo sapiens_hsa040150.49590936
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48871456
117Glutamatergic synapse_Homo sapiens_hsa047240.48731184
118Non-homologous end-joining_Homo sapiens_hsa034500.47047405
119Nucleotide excision repair_Homo sapiens_hsa034200.47026253
120Oocyte meiosis_Homo sapiens_hsa041140.46593965
121Prion diseases_Homo sapiens_hsa050200.46400531
122Renal cell carcinoma_Homo sapiens_hsa052110.46164676
123Glucagon signaling pathway_Homo sapiens_hsa049220.46043094
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45898627
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45530655
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45328439
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44597388
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43594499
129Sphingolipid metabolism_Homo sapiens_hsa006000.42557501
130Dopaminergic synapse_Homo sapiens_hsa047280.42183961
131GnRH signaling pathway_Homo sapiens_hsa049120.41699612
132Melanoma_Homo sapiens_hsa052180.41573897
133Mineral absorption_Homo sapiens_hsa049780.41189467
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40683377
135Endocytosis_Homo sapiens_hsa041440.39756360
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39629791
137RNA polymerase_Homo sapiens_hsa030200.38250625
138Spliceosome_Homo sapiens_hsa030400.38014570
139AMPK signaling pathway_Homo sapiens_hsa041520.37677268
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36796005
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36793394
142Pancreatic cancer_Homo sapiens_hsa052120.36692041
143Synaptic vesicle cycle_Homo sapiens_hsa047210.36256377
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35987076
145ErbB signaling pathway_Homo sapiens_hsa040120.35896190
146Cocaine addiction_Homo sapiens_hsa050300.35765213
147Basal transcription factors_Homo sapiens_hsa030220.35612628
148Fat digestion and absorption_Homo sapiens_hsa049750.34204091
149Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32469184
150Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31261120

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