AMHR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.89310457
2cellular response to follicle-stimulating hormone stimulus (GO:0071372)7.89115713
3negative regulation of metanephros development (GO:0072217)7.70927609
4poly(A)+ mRNA export from nucleus (GO:0016973)7.01883713
5cellular response to gonadotropin stimulus (GO:0071371)6.99968218
6response to follicle-stimulating hormone (GO:0032354)6.49667346
7transcription from mitochondrial promoter (GO:0006390)6.46672568
8regulation of meiosis I (GO:0060631)6.06219689
9piRNA metabolic process (GO:0034587)5.90217786
10regulation of cardioblast differentiation (GO:0051890)5.82905436
11proline metabolic process (GO:0006560)5.78252793
12embryonic process involved in female pregnancy (GO:0060136)5.76630829
13replication fork processing (GO:0031297)5.75704158
14negative regulation of macrophage differentiation (GO:0045650)5.62975450
15establishment of apical/basal cell polarity (GO:0035089)5.58186924
16mitotic G1 DNA damage checkpoint (GO:0031571)5.50264129
17gonadal mesoderm development (GO:0007506)5.38074858
18regulation of female gonad development (GO:2000194)5.33115428
19response to gonadotropin (GO:0034698)5.30382961
20maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.01287535
21G1 DNA damage checkpoint (GO:0044783)4.99419858
22atrioventricular valve morphogenesis (GO:0003181)4.97824998
23positive regulation of male gonad development (GO:2000020)4.96453364
24synaptonemal complex organization (GO:0070193)4.96096314
25sex determination (GO:0007530)4.95102267
26DNA deamination (GO:0045006)4.93356396
27synaptonemal complex assembly (GO:0007130)4.89018531
28regulation of protein homooligomerization (GO:0032462)4.88919884
29hemoglobin metabolic process (GO:0020027)4.85882134
30establishment of monopolar cell polarity (GO:0061162)4.84341855
31establishment or maintenance of monopolar cell polarity (GO:0061339)4.84341855
32SMAD protein signal transduction (GO:0060395)4.83043490
33mitotic G1/S transition checkpoint (GO:0044819)4.78003457
34positive regulation of protein homooligomerization (GO:0032464)4.73325866
35regulation of integrin activation (GO:0033623)4.54984949
36endocardial cushion development (GO:0003197)4.49167773
37seminiferous tubule development (GO:0072520)4.47364542
38short-chain fatty acid metabolic process (GO:0046459)4.46119091
39muscle cell fate commitment (GO:0042693)4.43134029
40mitochondrial DNA metabolic process (GO:0032042)4.41918975
41fusion of sperm to egg plasma membrane (GO:0007342)4.36696087
42oxidative demethylation (GO:0070989)4.32280119
43histone H4-K12 acetylation (GO:0043983)4.26705410
44male meiosis (GO:0007140)4.25174951
45regulation of RNA export from nucleus (GO:0046831)4.24150728
46regulation of male gonad development (GO:2000018)4.16178101
47somatic hypermutation of immunoglobulin genes (GO:0016446)4.09802292
48somatic diversification of immune receptors via somatic mutation (GO:0002566)4.09802292
49DNA strand renaturation (GO:0000733)4.04814151
50DNA methylation involved in gamete generation (GO:0043046)3.94187230
51cardiac muscle adaptation (GO:0014887)3.94147026
52cardiac muscle hypertrophy in response to stress (GO:0014898)3.94147026
53muscle hypertrophy in response to stress (GO:0003299)3.94147026
54negative regulation of kidney development (GO:0090185)3.93816435
55mesenchymal to epithelial transition (GO:0060231)3.92832896
56diaphragm development (GO:0060539)3.91324835
57meiotic chromosome segregation (GO:0045132)3.91110701
58protoporphyrinogen IX metabolic process (GO:0046501)3.88798253
59protoporphyrinogen IX biosynthetic process (GO:0006782)3.85516978
60spliceosomal tri-snRNP complex assembly (GO:0000244)3.80912040
61cellular response to ATP (GO:0071318)3.79161577
62mRNA cleavage (GO:0006379)3.78954196
63regulation of nucleobase-containing compound transport (GO:0032239)3.77425442
64cardiac right ventricle morphogenesis (GO:0003215)3.76612943
65viral mRNA export from host cell nucleus (GO:0046784)3.76403158
66negative regulation of protein oligomerization (GO:0032460)3.74824798
67negative regulation of JAK-STAT cascade (GO:0046426)3.73808851
68resolution of meiotic recombination intermediates (GO:0000712)3.73439499
69negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.71085187
70positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.69085397
71positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.69085397
72positive regulation of mitotic sister chromatid separation (GO:1901970)3.69085397
73regulation of protein polyubiquitination (GO:1902914)3.68264662
74labyrinthine layer development (GO:0060711)3.65129199
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63305487
76plasma lipoprotein particle assembly (GO:0034377)3.62537150
77regulation of sister chromatid cohesion (GO:0007063)3.60180540
78skeletal muscle organ development (GO:0060538)3.59094570
79regulation of cholesterol esterification (GO:0010872)3.59059968
80male sex determination (GO:0030238)3.57743504
81embryonic foregut morphogenesis (GO:0048617)3.56402880
82response to parathyroid hormone (GO:0071107)3.56191111
83establishment of protein localization to mitochondrial membrane (GO:0090151)3.55982288
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.55833434
85meiotic nuclear division (GO:0007126)3.54210349
86metanephric mesenchyme development (GO:0072075)3.50158754
87phospholipid efflux (GO:0033700)3.48471997
88embryonic placenta development (GO:0001892)3.44910515
89formation of translation preinitiation complex (GO:0001731)3.44623059
90male meiosis I (GO:0007141)3.37816630
91regulation of DNA damage checkpoint (GO:2000001)3.36605073
92negative regulation of Ras GTPase activity (GO:0034261)3.36602892
93atrial septum morphogenesis (GO:0060413)3.33982812
94mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33603227
95progesterone metabolic process (GO:0042448)3.33513725
96oogenesis (GO:0048477)3.26737136
97glomerulus development (GO:0032835)3.25486765
98regulation of translational fidelity (GO:0006450)3.23082556
99embryonic camera-type eye development (GO:0031076)3.21936869
100DNA integration (GO:0015074)3.21143131
101regulation of double-strand break repair (GO:2000779)3.20684797
102base-excision repair (GO:0006284)3.20285925
103protein-lipid complex assembly (GO:0065005)3.20162052
104epithelial cell fate commitment (GO:0072148)3.19987574
105mesonephros development (GO:0001823)3.19812071
106male genitalia development (GO:0030539)3.19452402
107face development (GO:0060324)3.18953184
108proteasome assembly (GO:0043248)3.18536791
109regulation of cilium movement (GO:0003352)3.16731311
110negative regulation of cell cycle arrest (GO:0071157)3.16410772
111oxidative phosphorylation (GO:0006119)3.16341394
112histone H4-K5 acetylation (GO:0043981)3.14832846
113histone H4-K8 acetylation (GO:0043982)3.14832846
114positive regulation of chromosome segregation (GO:0051984)3.14698232
115negative regulation of mRNA processing (GO:0050686)3.13403237
116regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.13261939
117high-density lipoprotein particle remodeling (GO:0034375)3.12815917
118regulation of double-strand break repair via homologous recombination (GO:0010569)3.12797190
119double-strand break repair via nonhomologous end joining (GO:0006303)3.12570545
120non-recombinational repair (GO:0000726)3.12570545
121negative regulation of fatty acid biosynthetic process (GO:0045717)3.12267405
122trophectodermal cell differentiation (GO:0001829)3.10824512
123cardiac muscle hypertrophy (GO:0003300)3.10169720
124epithelial cilium movement (GO:0003351)3.09860216
125dosage compensation (GO:0007549)3.09678526
126ubiquinone metabolic process (GO:0006743)3.09170024
127regulation of mesenchymal cell apoptotic process (GO:2001053)3.08880484
128plasma membrane fusion (GO:0045026)3.08759616
129chromosome organization involved in meiosis (GO:0070192)3.08379950
130termination of RNA polymerase II transcription (GO:0006369)3.07969340
131axonemal dynein complex assembly (GO:0070286)3.07674546
132heme biosynthetic process (GO:0006783)3.06747879
133regulation of gonadotropin secretion (GO:0032276)3.06720037
134mRNA export from nucleus (GO:0006406)3.04082221
135androgen biosynthetic process (GO:0006702)3.04077127
136galactose catabolic process (GO:0019388)3.01957772
137regulation of cell proliferation involved in kidney development (GO:1901722)3.01434515
138parturition (GO:0007567)3.00410638
139negative regulation of meiosis (GO:0045835)2.99507149
140activation of Rac GTPase activity (GO:0032863)2.96561956
141meiotic cell cycle process (GO:1903046)2.95893207
142male gonad development (GO:0008584)2.95569374
143porphyrin-containing compound biosynthetic process (GO:0006779)2.95170730
144creatine metabolic process (GO:0006600)2.94926946
145ketone biosynthetic process (GO:0042181)2.93395106
146lipopolysaccharide biosynthetic process (GO:0009103)2.93235934
147ubiquinone biosynthetic process (GO:0006744)2.92873965
148tricarboxylic acid cycle (GO:0006099)2.91316716
149glutamine family amino acid biosynthetic process (GO:0009084)2.91299258
150striated muscle hypertrophy (GO:0014897)2.91089773
151DNA double-strand break processing (GO:0000729)2.90987388
152positive regulation of heart growth (GO:0060421)2.89654352
153kidney mesenchyme development (GO:0072074)2.89268518
154regulation of protein oligomerization (GO:0032459)2.89009047
155gene silencing by RNA (GO:0031047)2.87688964
156positive regulation by host of viral transcription (GO:0043923)2.86141360
157meiosis I (GO:0007127)2.85955174
158gas transport (GO:0015669)2.85086937
159regulation of cardiac muscle cell contraction (GO:0086004)2.84878646
160biotin metabolic process (GO:0006768)2.84691160
161convergent extension (GO:0060026)2.84637211
162adrenal gland development (GO:0030325)2.83409598
163maturation of 5.8S rRNA (GO:0000460)2.82696391
164valine metabolic process (GO:0006573)2.81857846
165C21-steroid hormone metabolic process (GO:0008207)2.80906124
166regulation of hippo signaling (GO:0035330)2.79680745
167telomere maintenance via semi-conservative replication (GO:0032201)2.77950809
168regulation of mitochondrial translation (GO:0070129)2.77434421
169nodal signaling pathway (GO:0038092)2.77062470
170oxygen transport (GO:0015671)2.72925381
171energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71919118
172ATP synthesis coupled proton transport (GO:0015986)2.71919118
173heme metabolic process (GO:0042168)2.71580968
174glomerular basement membrane development (GO:0032836)2.69828867
175IMP biosynthetic process (GO:0006188)2.69719839
176isoprenoid biosynthetic process (GO:0008299)2.67958684
177negative regulation of lipase activity (GO:0060192)2.67704015
178estrogen biosynthetic process (GO:0006703)2.67488797
179cellular response to BMP stimulus (GO:0071773)2.64218966
180response to BMP (GO:0071772)2.64218966
181erythrocyte maturation (GO:0043249)2.63686063
182tetrapyrrole biosynthetic process (GO:0033014)2.62914926
183glutathione derivative metabolic process (GO:1901685)2.61928481
184glutathione derivative biosynthetic process (GO:1901687)2.61928481
185reverse cholesterol transport (GO:0043691)2.61883106
186cholesterol biosynthetic process (GO:0006695)2.60861647
187regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.59914505
188very-low-density lipoprotein particle assembly (GO:0034379)2.58995980
189regulation of glomerulus development (GO:0090192)2.57833511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.93769255
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.48208635
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.70343548
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.70343548
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.70343548
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.49510490
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.45608438
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.26020884
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.22366573
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.00956194
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.91188310
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74713451
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.63254330
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50412430
15PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.45703721
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.40939122
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.39241190
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.36366399
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.35940790
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32219238
21ZNF263_19887448_ChIP-Seq_K562_Human2.29867039
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.29073868
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.26867977
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.24528069
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.22160429
26FOXP3_21729870_ChIP-Seq_TREG_Human2.08358729
27POU5F1_16518401_ChIP-PET_MESCs_Mouse2.07416649
28KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.07407277
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03737968
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02984768
31* GATA1_19941826_ChIP-Seq_K562_Human2.02816314
32VDR_23849224_ChIP-Seq_CD4+_Human2.02226174
33XRN2_22483619_ChIP-Seq_HELA_Human2.00069302
34SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.99185645
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98228022
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98183156
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95368187
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.92687624
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90385160
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87529114
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86576588
42VDR_21846776_ChIP-Seq_THP-1_Human1.83594679
43NCOR1_26117541_ChIP-Seq_K562_Human1.81926973
44NANOG_21062744_ChIP-ChIP_HESCs_Human1.78587999
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78505354
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.76980766
47E2F7_22180533_ChIP-Seq_HELA_Human1.76466675
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75216772
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75086095
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72734185
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.72522283
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72242629
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71592753
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70589639
55TTF2_22483619_ChIP-Seq_HELA_Human1.68867164
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.68438011
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.67975789
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66228792
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.65529783
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.63857752
61LXR_22292898_ChIP-Seq_THP-1_Human1.63299926
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63212557
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61154137
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59334959
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55396009
66* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48645674
67NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.48250506
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48120099
69ELK1_19687146_ChIP-ChIP_HELA_Human1.47809726
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.47597285
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46776598
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.46739863
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.46728007
74RACK7_27058665_Chip-Seq_MCF-7_Human1.44628307
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44245648
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43744125
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43477221
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.42130286
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.41388547
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38187614
81* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37010162
82KDM2B_26808549_Chip-Seq_DND41_Human1.36695636
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34792645
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34266329
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34193954
86POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34041783
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33892741
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32856154
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32357754
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31309010
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31105568
92KDM5A_27292631_Chip-Seq_BREAST_Human1.30613065
93ETS1_21867929_ChIP-Seq_TH2_Mouse1.28800451
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28652074
95ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28097416
96SOX2_18692474_ChIP-Seq_MESCs_Mouse1.27511194
97ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25724975
98MYC_22102868_ChIP-Seq_BL_Human1.25304243
99RXRA_24833708_ChIP-Seq_LIVER_Mouse1.24001128
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23714253
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23072174
102NANOG_18692474_ChIP-Seq_MESCs_Mouse1.22234631
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21847610
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21812296
105GATA4_21415370_ChIP-Seq_HL-1_Mouse1.20968330
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20480405
107PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.20206043
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20204053
109* RARB_24833708_ChIP-Seq_LIVER_Mouse1.19950681
110EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19860746
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19597389
112MYC_18940864_ChIP-ChIP_HL60_Human1.18486233
113NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18215465
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17500200
115GABP_19822575_ChIP-Seq_HepG2_Human1.17438705
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16399275
117* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16048129
118* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15844836
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15505744
120MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13288787
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12919317
122SPI1_26923725_Chip-Seq_HPCs_Mouse1.12842919
123THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12705444
124ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12671219
125SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12093132
126E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10858903
127ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10320466
128SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.09849928
129EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09210068
130TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09101910
131MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08812834
132RARA_24833708_ChIP-Seq_LIVER_Mouse1.08801033
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08406419
134KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08316019
135TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.08086462
136E2F1_20622854_ChIP-Seq_HELA_Human1.07939152
137P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07481919
138DCP1A_22483619_ChIP-Seq_HELA_Human1.07372234
139PHF8_20622854_ChIP-Seq_HELA_Human1.06671031
140GATA2_19941826_ChIP-Seq_K562_Human1.05523980
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03142193
142* EOMES_21245162_ChIP-Seq_HESCs_Human1.02560507
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02505035
144POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01999373
145YY1_22570637_ChIP-Seq_MALME-3M_Human1.01893477
146* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01526848
147KAP1_27257070_Chip-Seq_ESCs_Mouse1.01443453
148BCOR_27268052_Chip-Seq_Bcells_Human1.01375514
149ETS1_20019798_ChIP-Seq_JURKAT_Human1.00742323
150HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00627702
151TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94468721
152ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93444785
153KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91535607
154CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91115769
155SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91064528
156* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87269707
157E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87250631
158SOX17_20123909_ChIP-Seq_XEN_Mouse0.86926639
159AR_21909140_ChIP-Seq_LNCAP_Human0.85717511
160SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83015177
161SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82456120
162CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82238540
163CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81442242
164* RXR_22158963_ChIP-Seq_LIVER_Mouse0.79742337
165TFEB_21752829_ChIP-Seq_HELA_Human0.79002486
166CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.78528596
167CIITA_25753668_ChIP-Seq_RAJI_Human0.78121594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.71695522
2MP0009278_abnormal_bone_marrow4.39769032
3MP0005171_absent_coat_pigmentation3.75232643
4MP0000537_abnormal_urethra_morphology3.56422524
5MP0003878_abnormal_ear_physiology3.55999547
6MP0005377_hearing/vestibular/ear_phenot3.55999547
7MP0004147_increased_porphyrin_level3.44832729
8MP0000516_abnormal_urinary_system3.33706374
9MP0005367_renal/urinary_system_phenotyp3.33706374
10* MP0008995_early_reproductive_senescence3.08709834
11MP0002009_preneoplasia2.97789762
12MP0004233_abnormal_muscle_weight2.82940501
13MP0009384_cardiac_valve_regurgitation2.80274013
14MP0010094_abnormal_chromosome_stability2.44351602
15MP0002653_abnormal_ependyma_morphology2.40973537
16* MP0003786_premature_aging2.40723174
17MP0010030_abnormal_orbit_morphology2.32165733
18* MP0002210_abnormal_sex_determination2.32152561
19* MP0001929_abnormal_gametogenesis2.25632330
20MP0003186_abnormal_redox_activity2.24399190
21MP0009840_abnormal_foam_cell2.22398698
22* MP0001145_abnormal_male_reproductive2.21532736
23MP0003121_genomic_imprinting2.20884243
24MP0004145_abnormal_muscle_electrophysio2.20059480
25MP0004957_abnormal_blastocyst_morpholog2.11071783
26* MP0008877_abnormal_DNA_methylation2.08768910
27MP0003890_abnormal_embryonic-extraembry2.07354309
28MP0003111_abnormal_nucleus_morphology2.02960600
29MP0005397_hematopoietic_system_phenotyp2.02795181
30MP0001545_abnormal_hematopoietic_system2.02795181
31MP0005076_abnormal_cell_differentiation2.01047076
32MP0003283_abnormal_digestive_organ1.97634456
33MP0003119_abnormal_digestive_system1.97139862
34MP0003806_abnormal_nucleotide_metabolis1.89934356
35* MP0003698_abnormal_male_reproductive1.88667659
36MP0003656_abnormal_erythrocyte_physiolo1.88555046
37* MP0005410_abnormal_fertilization1.86708641
38MP0005647_abnormal_sex_gland1.85771540
39* MP0000653_abnormal_sex_gland1.81102082
40MP0008058_abnormal_DNA_repair1.78394503
41MP0003045_fibrosis1.75184659
42MP0006036_abnormal_mitochondrial_physio1.72331859
43MP0002132_abnormal_respiratory_system1.70398536
44MP0006072_abnormal_retinal_apoptosis1.64071374
45MP0002084_abnormal_developmental_patter1.61092173
46MP0008004_abnormal_stomach_pH1.59399610
47MP0001661_extended_life_span1.56926855
48MP0004197_abnormal_fetal_growth/weight/1.54677424
49MP0001764_abnormal_homeostasis1.53838678
50MP0002139_abnormal_hepatobiliary_system1.51106410
51MP0003077_abnormal_cell_cycle1.50269789
52MP0003221_abnormal_cardiomyocyte_apopto1.49421315
53MP0008932_abnormal_embryonic_tissue1.48594067
54MP0004264_abnormal_extraembryonic_tissu1.48338799
55MP0002282_abnormal_trachea_morphology1.48250856
56MP0003693_abnormal_embryo_hatching1.44834387
57MP0001697_abnormal_embryo_size1.44756695
58MP0006138_congestive_heart_failure1.41751535
59* MP0002086_abnormal_extraembryonic_tissu1.40702496
60MP0002085_abnormal_embryonic_tissue1.39922218
61MP0002127_abnormal_cardiovascular_syste1.39607996
62MP0004133_heterotaxia1.38158634
63MP0003567_abnormal_fetal_cardiomyocyte1.37678296
64MP0001730_embryonic_growth_arrest1.35773094
65* MP0002161_abnormal_fertility/fecundity1.30234490
66MP0001672_abnormal_embryogenesis/_devel1.28762494
67MP0005380_embryogenesis_phenotype1.28762494
68MP0009333_abnormal_splenocyte_physiolog1.27328214
69MP0003718_maternal_effect1.27312752
70MP0002249_abnormal_larynx_morphology1.26913775
71MP0009672_abnormal_birth_weight1.26373446
72MP0001293_anophthalmia1.26068312
73MP0001666_abnormal_nutrient_absorption1.23109329
74MP0004019_abnormal_vitamin_homeostasis1.22382036
75MP0006035_abnormal_mitochondrial_morpho1.20603815
76MP0001986_abnormal_taste_sensitivity1.20539829
77MP0005636_abnormal_mineral_homeostasis1.20092584
78MP0000678_abnormal_parathyroid_gland1.16217057
79MP0000470_abnormal_stomach_morphology1.14006190
80MP0005174_abnormal_tail_pigmentation1.13044909
81MP0010307_abnormal_tumor_latency1.12826297
82MP0003453_abnormal_keratinocyte_physiol1.12258223
83MP0000350_abnormal_cell_proliferation1.10603239
84MP0009703_decreased_birth_body1.06408013
85MP0000372_irregular_coat_pigmentation1.06120000
86* MP0003936_abnormal_reproductive_system1.05495743
87MP0005395_other_phenotype1.04912118
88MP0005085_abnormal_gallbladder_physiolo1.03499522
89MP0005365_abnormal_bile_salt1.03100362
90MP0002638_abnormal_pupillary_reflex1.03069792
91MP0003984_embryonic_growth_retardation1.00249928
92MP0001340_abnormal_eyelid_morphology0.99419291
93MP0000371_diluted_coat_color0.99408647
94MP0009697_abnormal_copulation0.99366868
95* MP0003942_abnormal_urinary_system0.99163977
96MP0003011_delayed_dark_adaptation0.97681456
97MP0002269_muscular_atrophy0.97135948
98MP0005220_abnormal_exocrine_pancreas0.96502015
99MP0002088_abnormal_embryonic_growth/wei0.95762789
100MP0003943_abnormal_hepatobiliary_system0.94699164
101* MP0002080_prenatal_lethality0.94511061
102MP0003195_calcinosis0.93135079
103MP0005623_abnormal_meninges_morphology0.92524898
104MP0002160_abnormal_reproductive_system0.92418731
105MP0005389_reproductive_system_phenotype0.92300365
106MP0005451_abnormal_body_composition0.90462410
107MP0005330_cardiomyopathy0.90015255
108MP0002168_other_aberrant_phenotype0.89883054
109MP0000462_abnormal_digestive_system0.87745532
110MP0010329_abnormal_lipoprotein_level0.87680059
111MP0003879_abnormal_hair_cell0.86542802
112MP0000751_myopathy0.86183637
113MP0003115_abnormal_respiratory_system0.85546423
114MP0003122_maternal_imprinting0.84454516
115MP0010352_gastrointestinal_tract_polyps0.84210789
116MP0002111_abnormal_tail_morphology0.83211814
117MP0003935_abnormal_craniofacial_develop0.83018224
118MP0002938_white_spotting0.82941556
119MP0003315_abnormal_perineum_morphology0.81973778
120* MP0003699_abnormal_female_reproductive0.81452899
121MP0004215_abnormal_myocardial_fiber0.81099173
122MP0000598_abnormal_liver_morphology0.80121761
123MP0005083_abnormal_biliary_tract0.79877116
124MP0000015_abnormal_ear_pigmentation0.78048058
125MP0003646_muscle_fatigue0.76882091
126MP0005332_abnormal_amino_acid0.76246880
127MP0000749_muscle_degeneration0.76079877
128* MP0001119_abnormal_female_reproductive0.75398824
129MP0005058_abnormal_lysosome_morphology0.75100529
130MP0003123_paternal_imprinting0.74869407
131MP0000579_abnormal_nail_morphology0.73852462
132MP0002114_abnormal_axial_skeleton0.73662373
133MP0004085_abnormal_heartbeat0.73633953
134MP0000313_abnormal_cell_death0.73556388
135MP0003828_pulmonary_edema0.73395284
136MP0001919_abnormal_reproductive_system0.72885861
137MP0002796_impaired_skin_barrier0.72626123
138MP0003755_abnormal_palate_morphology0.72001331
139MP0002102_abnormal_ear_morphology0.71388138
140MP0003191_abnormal_cellular_cholesterol0.69435242
141MP0002106_abnormal_muscle_physiology0.69391201
142MP0000432_abnormal_head_morphology0.67627860
143MP0002116_abnormal_craniofacial_bone0.66432959
144MP0000490_abnormal_crypts_of0.65944423
145MP0005391_vision/eye_phenotype0.65013591
146* MP0002019_abnormal_tumor_incidence0.64727389
147MP0010630_abnormal_cardiac_muscle0.62365430
148* MP0000639_abnormal_adrenal_gland0.62239309
149MP0002932_abnormal_joint_morphology0.59802366
150MP0002092_abnormal_eye_morphology0.59789331
151MP0004134_abnormal_chest_morphology0.58297290
152MP0000762_abnormal_tongue_morphology0.58062215

Predicted human phenotypes

RankGene SetZ-score
1Hypoplastic left heart (HP:0004383)6.31877165
2Tongue fasciculations (HP:0001308)5.53112605
3Gonadal dysgenesis (HP:0000133)5.20916697
4Muscle fibrillation (HP:0010546)5.06745610
5Abnormal ventriculo-arterial connection (HP:0011563)4.98802571
6Transposition of the great arteries (HP:0001669)4.98802571
7Abnormal connection of the cardiac segments (HP:0011545)4.98802571
8Hypoplastic heart (HP:0001961)4.96275314
9Gonadotropin excess (HP:0000837)4.64667866
10Facial hemangioma (HP:0000329)4.50838798
11Rib fusion (HP:0000902)4.24069438
12Diaphragmatic weakness (HP:0009113)4.22511903
13Annular pancreas (HP:0001734)4.20213406
14Alopecia of scalp (HP:0002293)4.19451231
15Concave nail (HP:0001598)4.09496455
16Pustule (HP:0200039)4.01390306
17Sex reversal (HP:0012245)3.89081432
18Abnormal sex determination (HP:0012244)3.89081432
19Anomalous pulmonary venous return (HP:0010772)3.87421539
20Preauricular pit (HP:0004467)3.77876286
21Periauricular skin pits (HP:0100277)3.77876286
22Rectovaginal fistula (HP:0000143)3.73797269
23Rectal fistula (HP:0100590)3.73797269
24Abnormality of the heme biosynthetic pathway (HP:0010472)3.67736357
25Abnormality of the lower motor neuron (HP:0002366)3.65742425
26Turricephaly (HP:0000262)3.61942434
27Poikiloderma (HP:0001029)3.61219270
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.59222150
29Abnormality of the pulmonary veins (HP:0011718)3.47199570
30Clumsiness (HP:0002312)3.45051766
31Short humerus (HP:0005792)3.43099253
32Intestinal fistula (HP:0100819)3.42331140
33Female pseudohermaphroditism (HP:0010458)3.38606237
34Aplasia/hypoplasia of the humerus (HP:0006507)3.37939151
35Metaphyseal cupping (HP:0003021)3.37567786
36Truncus arteriosus (HP:0001660)3.31179155
37Ulnar bowing (HP:0003031)3.30785238
38Hyperglycinemia (HP:0002154)3.23936645
39Reticulocytosis (HP:0001923)3.22504927
40Selective tooth agenesis (HP:0001592)3.22339063
41Vaginal fistula (HP:0004320)3.22044592
42Increased IgM level (HP:0003496)3.19769565
43Abnormal respiratory motile cilium morphology (HP:0005938)3.12662906
44Abnormal respiratory epithelium morphology (HP:0012253)3.12662906
45Coronal craniosynostosis (HP:0004440)3.11299145
46Acute encephalopathy (HP:0006846)3.05961357
47Azoospermia (HP:0000027)3.04872764
48Abnormal lung lobation (HP:0002101)3.03385248
49Primary adrenal insufficiency (HP:0008207)3.01327849
50Abnormality of the aortic arch (HP:0012303)2.98613107
51Abnormal gallbladder physiology (HP:0012438)2.95117768
52Cholecystitis (HP:0001082)2.95117768
53* Abnormality of male internal genitalia (HP:0000022)2.95116718
54Degeneration of the lateral corticospinal tracts (HP:0002314)2.93159913
55Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.93159913
56Hypoplasia of the uterus (HP:0000013)2.92440237
57Broad alveolar ridges (HP:0000187)2.86359601
58Testicular neoplasm (HP:0010788)2.81910928
5911 pairs of ribs (HP:0000878)2.79236232
60Absent radius (HP:0003974)2.77875811
61Abnormal spermatogenesis (HP:0008669)2.70302939
62Poikilocytosis (HP:0004447)2.66300852
63Ovarian neoplasm (HP:0100615)2.60769702
64Bulbar palsy (HP:0001283)2.59732530
65Abnormal hemoglobin (HP:0011902)2.59729080
66* Infertility (HP:0000789)2.59444829
67Aplasia involving forearm bones (HP:0009822)2.58718881
68Absent forearm bone (HP:0003953)2.58718881
69Missing ribs (HP:0000921)2.58009543
70Germ cell neoplasia (HP:0100728)2.56597385
71Hypochromic microcytic anemia (HP:0004840)2.56122078
72Orthostatic hypotension (HP:0001278)2.55879367
73Spinal muscular atrophy (HP:0007269)2.55805103
74Cerebral aneurysm (HP:0004944)2.54058275
75Osteomalacia (HP:0002749)2.53661026
76Beaking of vertebral bodies (HP:0004568)2.53393088
77Vertebral hypoplasia (HP:0008417)2.52974597
78Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.52974597
79Hand muscle atrophy (HP:0009130)2.52193999
80Abnormality of reticulocytes (HP:0004312)2.51285080
81* Male infertility (HP:0003251)2.49998856
82Premature ovarian failure (HP:0008209)2.49862620
83Congenital hip dislocation (HP:0001374)2.48987606
84Large for gestational age (HP:0001520)2.48680253
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.47558258
86Absent thumb (HP:0009777)2.47170782
87Anteriorly placed anus (HP:0001545)2.46521787
88Patellar aplasia (HP:0006443)2.46036164
89Increased serum pyruvate (HP:0003542)2.43763115
90Squamous cell carcinoma (HP:0002860)2.43038361
91Stridor (HP:0010307)2.41799307
92Nausea (HP:0002018)2.41116239
93Skin pits (HP:0100276)2.40168493
94Polycythemia (HP:0001901)2.39037062
95True hermaphroditism (HP:0010459)2.38655951
96Nephroblastoma (Wilms tumor) (HP:0002667)2.32921671
97Dysautonomia (HP:0002459)2.32548411
98* Male pseudohermaphroditism (HP:0000037)2.32482244
99Atrophy/Degeneration involving motor neurons (HP:0007373)2.32127054
100Abnormality of glycolysis (HP:0004366)2.31457839
101Hypotelorism (HP:0000601)2.30197606
102Mesangial abnormality (HP:0001966)2.29127533
103Short chin (HP:0000331)2.28815778
104Abnormal pancreas size (HP:0012094)2.28076505
105Aplasia/Hypoplasia of the patella (HP:0006498)2.26999504
106Increased CSF lactate (HP:0002490)2.25283643
107Abnormal mitochondria in muscle tissue (HP:0008316)2.23730412
108Capillary hemangiomas (HP:0005306)2.22920074
109Secondary amenorrhea (HP:0000869)2.22499405
110Acute necrotizing encephalopathy (HP:0006965)2.21512982
111Embryonal renal neoplasm (HP:0011794)2.20741983
112Basal cell carcinoma (HP:0002671)2.20476834
113Intestinal atresia (HP:0011100)2.19291474
114Abnormal tarsal ossification (HP:0008369)2.18575623
115Median cleft lip (HP:0000161)2.18367282
116Abnormality of the vocal cords (HP:0008777)2.15507162
117Tetralogy of Fallot (HP:0001636)2.13980164
118Complete atrioventricular canal defect (HP:0001674)2.12474106
119Gout (HP:0001997)2.12397990
120Spontaneous abortion (HP:0005268)2.08913337
121Pulmonary fibrosis (HP:0002206)2.07793343
122Abnormality of the astrocytes (HP:0100707)2.07642963
123Astrocytoma (HP:0009592)2.07642963
124Alacrima (HP:0000522)2.07423614
125Abnormality of the labia minora (HP:0012880)2.05546928
126Chronic hepatic failure (HP:0100626)2.04867817
127Volvulus (HP:0002580)2.04790790
128Abnormality of methionine metabolism (HP:0010901)2.03677947
129Hamartoma (HP:0010566)2.03134358
130Upper motor neuron abnormality (HP:0002127)2.02849645
131Dry hair (HP:0011359)2.02703370
132Hypoplasia of the radius (HP:0002984)1.99990271
133Aplasia/hypoplasia of the uterus (HP:0008684)1.99315393
134Hypoplastic pelvis (HP:0008839)1.98974438
135Albinism (HP:0001022)1.98808169
136Fasciculations (HP:0002380)1.96997591
137Hypotrichosis (HP:0001006)1.95605913
138Abnormality of the corticospinal tract (HP:0002492)1.95432112
139Hepatic necrosis (HP:0002605)1.94433975
140Narrow nasal bridge (HP:0000446)1.94284167
141Atrioventricular canal defect (HP:0006695)1.93488010
142Acanthocytosis (HP:0001927)1.92620284
143Thin ribs (HP:0000883)1.91648438
144Underdeveloped supraorbital ridges (HP:0009891)1.91081548
145Abnormal gallbladder morphology (HP:0012437)1.90972689
146Cholelithiasis (HP:0001081)1.90806506
147Upper limb amyotrophy (HP:0009129)1.90672768
148Distal upper limb amyotrophy (HP:0007149)1.90672768
149Premature skin wrinkling (HP:0100678)1.90122996
150Hyperthyroidism (HP:0000836)1.89797259
151Abnormality of the anterior horn cell (HP:0006802)1.87953472
152Degeneration of anterior horn cells (HP:0002398)1.87953472
153Impulsivity (HP:0100710)1.87794390
154Mitochondrial inheritance (HP:0001427)1.86375304
155Hepatocellular necrosis (HP:0001404)1.85801349
156Abnormality of serum amino acid levels (HP:0003112)1.84427545
157Vertebral fusion (HP:0002948)1.83846195
158Exercise-induced myalgia (HP:0003738)1.83768069
159Lactic acidosis (HP:0003128)1.83156309
160Heterotopia (HP:0002282)1.81862289
161Proximal placement of thumb (HP:0009623)1.80914792
162Choanal stenosis (HP:0000452)1.80221289
163Short 5th finger (HP:0009237)1.79976091
164Hyperpituitarism (HP:0010514)1.79700519
165Increased serum lactate (HP:0002151)1.79240392
166Urinary glycosaminoglycan excretion (HP:0003541)1.78901314
167Mucopolysacchariduria (HP:0008155)1.78901314
168Renal Fanconi syndrome (HP:0001994)1.78462965
169Cerebral palsy (HP:0100021)1.78343375
170Shoulder girdle muscle weakness (HP:0003547)1.77244858
171Renal cortical cysts (HP:0000803)1.76976302
172Renal salt wasting (HP:0000127)1.75726033
173Aplastic anemia (HP:0001915)1.75688985
174Ileus (HP:0002595)1.75452068
175Abnormality of sulfur amino acid metabolism (HP:0004339)1.74850427
176Rimmed vacuoles (HP:0003805)1.73211059
177Abnormality of alanine metabolism (HP:0010916)1.72941602
178Hyperalaninemia (HP:0003348)1.72941602
179Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72941602
180Hypoalphalipoproteinemia (HP:0003233)1.72656356
181Congenital diaphragmatic hernia (HP:0000776)1.72351745
182Amyotrophic lateral sclerosis (HP:0007354)1.71634020
183Cerebral edema (HP:0002181)1.71059940
184Limb hypertonia (HP:0002509)1.68921037
1853-Methylglutaconic aciduria (HP:0003535)1.68705928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.51182380
2MAPK154.63576557
3TYRO34.37853607
4DDR24.26109162
5EIF2AK33.69809214
6MAP3K63.55627505
7PLK43.22042250
8PBK3.15853026
9PINK12.93608546
10EIF2AK12.92000548
11ACVR1B2.78026841
12MAP3K112.66216625
13CDK122.42538406
14FGR2.30016301
15MATK2.28738266
16CDK72.26456914
17NME12.20110964
18DAPK12.05818477
19BMX1.99619167
20PDGFRA1.98187334
21PRKD21.97101785
22STK41.94523313
23PDK41.80041988
24PDK31.80041988
25DYRK1B1.74601690
26CSK1.73377160
27CDK191.72382379
28STK161.71021353
29LATS21.69934965
30NEK11.68954070
31UHMK11.67374371
32KDR1.61911427
33MST41.60481801
34CLK11.58232451
35AKT31.49840313
36MUSK1.48919041
37OBSCN1.48329577
38YES11.42778980
39NUAK11.40663104
40SRPK11.37253423
41PIM21.33989124
42CDK61.33571977
43NEK21.33423619
44WEE11.31899462
45NME21.24939509
46VRK21.16911925
47PRKD31.14969098
48KSR21.14343040
49PIM11.13366716
50CDC42BPA1.12503907
51CHEK21.12012843
52PLK11.11494717
53TRIB31.10137501
54MAP3K81.09802647
55MTOR1.07500882
56PDK21.06059401
57MKNK11.04565695
58BMPR1B1.03511131
59STK31.01237971
60GSK3A0.99500646
61BMPR20.98136531
62DYRK30.97190470
63MAP3K100.94877749
64PASK0.94772464
65WNK30.94036093
66BCKDK0.93581139
67LATS10.91211951
68RPS6KA50.89107849
69RPS6KL10.88601165
70RPS6KC10.88601165
71PHKG10.88574631
72PHKG20.88574631
73NTRK30.88014688
74MAP3K20.85809316
75MYLK0.81669587
76PLK30.81620335
77ZAK0.81530667
78BUB10.78396123
79RIPK10.77980575
80ATR0.77278879
81TNIK0.77165276
82CDC70.77146434
83TRPM70.76745746
84RPS6KA60.76435331
85NLK0.74649254
86LRRK20.74608290
87CDK40.74420359
88RIPK40.74376367
89SCYL20.70075508
90MAPK110.68825575
91PRKAA10.65828388
92PRKACG0.64587958
93CHEK10.64122646
94BRD40.63996160
95CDK20.61493600
96CCNB10.60702515
97STK38L0.58901998
98PLK20.58466319
99RPS6KA10.57614700
100PIK3CG0.57580939
101TESK20.57388683
102PAK20.57338782
103NEK90.56619820
104MAPKAPK50.56527048
105VRK10.56081912
106INSRR0.54482775
107AKT20.54347254
108BRAF0.53970917
109TSSK60.51571130
110TNK20.50936663
111CSNK1G10.50822661
112ILK0.50254011
113ATM0.50183775
114MAP3K40.49910151
115CDK90.49175546
116MAP4K20.48468984
117PAK40.48296648
118TRIM280.44413751
119PRKACA0.44229736
120EGFR0.43679006
121MAPK10.43620640
122STK380.41909611
123PDGFRB0.41187134
124EPHA20.40148340
125CDK10.39514450
126MAPK30.38722237
127SGK10.38546145
128TTK0.38087354
129CSNK2A10.36673718
130MAP3K120.35661066
131RPS6KB10.34901541
132MAPK140.34012554
133MAPK100.33548990
134PTK20.32750367
135AURKA0.31872316
136AURKB0.31647740
137RPS6KB20.29740853
138PRPF4B0.29482861
139CSNK2A20.29278443
140PAK10.27399332
141ERBB30.27310762
142GSK3B0.26985140
143ALK0.25229968
144RAF10.25120233
145PTK2B0.25004932
146MKNK20.23948334
147WNK40.23780948
148CSNK1A1L0.22757165
149MAP2K20.22354058
150FGFR10.22117194
151TAOK10.21715223
152PRKDC0.21186908
153TAOK20.19455722
154DYRK20.19338343
155PRKAA20.18690790
156CSNK1E0.18197955

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.84358623
2Mismatch repair_Homo sapiens_hsa034303.89398911
3Base excision repair_Homo sapiens_hsa034103.84321753
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.29584116
5DNA replication_Homo sapiens_hsa030303.01516590
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.83093890
7RNA transport_Homo sapiens_hsa030132.80184658
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73561185
9mRNA surveillance pathway_Homo sapiens_hsa030152.71543659
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.63775611
11Propanoate metabolism_Homo sapiens_hsa006402.43936264
12Hedgehog signaling pathway_Homo sapiens_hsa043402.32469426
13Spliceosome_Homo sapiens_hsa030402.20098768
14Nucleotide excision repair_Homo sapiens_hsa034202.16735480
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12528325
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06827534
17Carbon metabolism_Homo sapiens_hsa012002.03615232
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02745956
19Steroid biosynthesis_Homo sapiens_hsa001002.02179436
20Fanconi anemia pathway_Homo sapiens_hsa034602.01776758
21Parkinsons disease_Homo sapiens_hsa050121.97226786
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.96261579
23Fat digestion and absorption_Homo sapiens_hsa049751.96188990
24Oxidative phosphorylation_Homo sapiens_hsa001901.94973306
25Ribosome_Homo sapiens_hsa030101.94925007
26Notch signaling pathway_Homo sapiens_hsa043301.94353189
27Fatty acid metabolism_Homo sapiens_hsa012121.91323263
28Hippo signaling pathway_Homo sapiens_hsa043901.90177176
29mTOR signaling pathway_Homo sapiens_hsa041501.87229015
30Homologous recombination_Homo sapiens_hsa034401.87061993
31Protein export_Homo sapiens_hsa030601.83900400
32Dorso-ventral axis formation_Homo sapiens_hsa043201.81103085
33Cell cycle_Homo sapiens_hsa041101.78562796
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.78412613
35Circadian rhythm_Homo sapiens_hsa047101.70272813
36Oocyte meiosis_Homo sapiens_hsa041141.58672581
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.52926109
38p53 signaling pathway_Homo sapiens_hsa041151.50055233
39Lysine degradation_Homo sapiens_hsa003101.50035662
40Adherens junction_Homo sapiens_hsa045201.44021601
41Arginine and proline metabolism_Homo sapiens_hsa003301.43263108
42Longevity regulating pathway - mammal_Homo sapiens_hsa042111.41704161
43Basal transcription factors_Homo sapiens_hsa030221.41112076
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40533976
45Biosynthesis of amino acids_Homo sapiens_hsa012301.40365605
46Huntingtons disease_Homo sapiens_hsa050161.36062705
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34017594
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32018231
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27008064
50Butanoate metabolism_Homo sapiens_hsa006501.26019139
51Basal cell carcinoma_Homo sapiens_hsa052171.24154963
52Vitamin B6 metabolism_Homo sapiens_hsa007501.22778257
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22694814
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21677855
55Pentose phosphate pathway_Homo sapiens_hsa000301.20083567
56Peroxisome_Homo sapiens_hsa041461.13402803
57RNA polymerase_Homo sapiens_hsa030201.12524686
58Small cell lung cancer_Homo sapiens_hsa052221.11746460
59Wnt signaling pathway_Homo sapiens_hsa043101.11708473
60* TGF-beta signaling pathway_Homo sapiens_hsa043501.08334690
61Alzheimers disease_Homo sapiens_hsa050101.04773989
62Sulfur relay system_Homo sapiens_hsa041221.04299903
63Galactose metabolism_Homo sapiens_hsa000521.03069276
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.00543129
65Vitamin digestion and absorption_Homo sapiens_hsa049771.00451760
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99948693
67Arginine biosynthesis_Homo sapiens_hsa002200.99775780
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99689666
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98909379
70Metabolic pathways_Homo sapiens_hsa011000.97114358
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95211605
72Tight junction_Homo sapiens_hsa045300.92919059
73Non-homologous end-joining_Homo sapiens_hsa034500.91115096
74Mineral absorption_Homo sapiens_hsa049780.90983225
75VEGF signaling pathway_Homo sapiens_hsa043700.90030847
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89023290
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84823182
78Folate biosynthesis_Homo sapiens_hsa007900.84245918
79Chemical carcinogenesis_Homo sapiens_hsa052040.83912765
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81922843
81Purine metabolism_Homo sapiens_hsa002300.79960722
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79630377
83Sulfur metabolism_Homo sapiens_hsa009200.75698646
84Fatty acid degradation_Homo sapiens_hsa000710.73097463
85Fructose and mannose metabolism_Homo sapiens_hsa000510.72545904
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67677469
87Colorectal cancer_Homo sapiens_hsa052100.64632852
88Shigellosis_Homo sapiens_hsa051310.64406024
89N-Glycan biosynthesis_Homo sapiens_hsa005100.63636094
90Cardiac muscle contraction_Homo sapiens_hsa042600.59893448
91AMPK signaling pathway_Homo sapiens_hsa041520.59279446
92MicroRNAs in cancer_Homo sapiens_hsa052060.58734595
93Bladder cancer_Homo sapiens_hsa052190.58662809
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58599159
95Herpes simplex infection_Homo sapiens_hsa051680.57349928
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.57211644
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57153929
98Fatty acid elongation_Homo sapiens_hsa000620.56048658
99Ovarian steroidogenesis_Homo sapiens_hsa049130.56004700
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.55970134
101Viral myocarditis_Homo sapiens_hsa054160.55950604
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.55831740
103Epstein-Barr virus infection_Homo sapiens_hsa051690.54823527
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54142589
105Viral carcinogenesis_Homo sapiens_hsa052030.52570857
106Choline metabolism in cancer_Homo sapiens_hsa052310.51320232
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50682149
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50063192
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.49571679
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49016446
111Glutathione metabolism_Homo sapiens_hsa004800.47969188
112Sphingolipid metabolism_Homo sapiens_hsa006000.47847908
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47667136
114Focal adhesion_Homo sapiens_hsa045100.47314074
115Glycerolipid metabolism_Homo sapiens_hsa005610.46969703
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46759111
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46751389
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.46089577
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45227055
120Selenocompound metabolism_Homo sapiens_hsa004500.44663953
121Insulin signaling pathway_Homo sapiens_hsa049100.44487031
122Proteasome_Homo sapiens_hsa030500.43989194
123ErbB signaling pathway_Homo sapiens_hsa040120.43905354
124RNA degradation_Homo sapiens_hsa030180.43785043
125Pyrimidine metabolism_Homo sapiens_hsa002400.43199241
126Complement and coagulation cascades_Homo sapiens_hsa046100.42948791
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40143767
128Pyruvate metabolism_Homo sapiens_hsa006200.39950785
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39465133
130Retinol metabolism_Homo sapiens_hsa008300.39072342
131One carbon pool by folate_Homo sapiens_hsa006700.38967807
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37544219
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36975888
134HTLV-I infection_Homo sapiens_hsa051660.35995827
135Nitrogen metabolism_Homo sapiens_hsa009100.34665588
136PPAR signaling pathway_Homo sapiens_hsa033200.34354431
137ECM-receptor interaction_Homo sapiens_hsa045120.32528514
138Estrogen signaling pathway_Homo sapiens_hsa049150.31614676
139Ether lipid metabolism_Homo sapiens_hsa005650.31215780
140Chronic myeloid leukemia_Homo sapiens_hsa052200.30816689
141Gap junction_Homo sapiens_hsa045400.30676803
142Pathways in cancer_Homo sapiens_hsa052000.30486155
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30332962
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29615976
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28885155
146Tyrosine metabolism_Homo sapiens_hsa003500.28715684
147Prostate cancer_Homo sapiens_hsa052150.28161092
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26388754
149Proteoglycans in cancer_Homo sapiens_hsa052050.26053589
150Glycosaminoglycan degradation_Homo sapiens_hsa005310.24707442
151Endometrial cancer_Homo sapiens_hsa052130.24653963
152Glucagon signaling pathway_Homo sapiens_hsa049220.24142382
153Legionellosis_Homo sapiens_hsa051340.24128739
154Thyroid cancer_Homo sapiens_hsa052160.23910331
155Acute myeloid leukemia_Homo sapiens_hsa052210.21183867
156Endocytosis_Homo sapiens_hsa041440.21094781
157Linoleic acid metabolism_Homo sapiens_hsa005910.20533794

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