AMIGO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)7.21369317
2cell-substrate junction assembly (GO:0007044)5.70406226
3endodermal cell differentiation (GO:0035987)5.58006855
4desmosome organization (GO:0002934)5.46920459
5mesodermal cell differentiation (GO:0048333)5.27013088
6synaptic vesicle maturation (GO:0016188)5.26085303
7cellular response to vitamin D (GO:0071305)5.15190257
8phenol-containing compound catabolic process (GO:0019336)5.06731554
9doxorubicin metabolic process (GO:0044598)4.77391321
10daunorubicin metabolic process (GO:0044597)4.77391321
11polyketide metabolic process (GO:0030638)4.77391321
12regulation of transforming growth factor beta2 production (GO:0032909)4.62340873
13hormone catabolic process (GO:0042447)4.60757814
14dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.58158455
15substrate-dependent cell migration (GO:0006929)4.55465820
16response to dietary excess (GO:0002021)4.48098680
17cellular response to vitamin (GO:0071295)4.44258476
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.40004133
19proline transport (GO:0015824)4.39196540
20COPI coating of Golgi vesicle (GO:0048205)4.29455746
21Golgi transport vesicle coating (GO:0048200)4.29455746
22skin morphogenesis (GO:0043589)4.22012245
23negative regulation of chondrocyte differentiation (GO:0032331)4.08259187
24protein localization to endosome (GO:0036010)4.08049866
25regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.06986040
26positive regulation of histone deacetylation (GO:0031065)3.97514200
27negative regulation of keratinocyte proliferation (GO:0010839)3.92177801
28regulation of glucose import in response to insulin stimulus (GO:2001273)3.88667613
29regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.71902395
30pyrimidine nucleoside salvage (GO:0043097)3.70173811
31pyrimidine-containing compound salvage (GO:0008655)3.70173811
32positive regulation of protein deacetylation (GO:0090312)3.68430897
33protein hydroxylation (GO:0018126)3.67409177
34response to pheromone (GO:0019236)3.66956792
35peptidyl-proline hydroxylation (GO:0019511)3.66622000
36epithelial cell-cell adhesion (GO:0090136)3.58967295
37neuromuscular process controlling posture (GO:0050884)3.58597306
38macroautophagy (GO:0016236)3.57284951
39hypotonic response (GO:0006971)3.56448001
40regulation of short-term neuronal synaptic plasticity (GO:0048172)3.55639352
41collagen fibril organization (GO:0030199)3.54984345
42membrane raft organization (GO:0031579)3.52937203
43wound healing, spreading of cells (GO:0044319)3.52331709
44regulation of apoptotic process involved in morphogenesis (GO:1902337)3.50417527
45wound healing, spreading of epidermal cells (GO:0035313)3.47709577
46regulation of synaptic vesicle exocytosis (GO:2000300)3.44760220
47positive regulation of endothelial cell apoptotic process (GO:2000353)3.43995075
48mitochondrial DNA replication (GO:0006264)3.43411782
49membrane protein ectodomain proteolysis (GO:0006509)3.38183140
50toxin metabolic process (GO:0009404)3.37183766
51regulation of transforming growth factor beta1 production (GO:0032908)3.32857207
52positive regulation of blood vessel endothelial cell migration (GO:0043536)3.32613469
53bundle of His cell to Purkinje myocyte communication (GO:0086069)3.32466042
54calcium-mediated signaling using intracellular calcium source (GO:0035584)3.29676457
55striatum development (GO:0021756)3.29615011
56somite rostral/caudal axis specification (GO:0032525)3.27142831
57heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.26780064
58protein targeting to Golgi (GO:0000042)3.23803760
59cell migration involved in sprouting angiogenesis (GO:0002042)3.23181224
60nerve growth factor signaling pathway (GO:0038180)3.20447880
61regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.18949463
62regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.18597426
63type B pancreatic cell proliferation (GO:0044342)3.18523655
64renal filtration (GO:0097205)3.18180936
65negative regulation of anoikis (GO:2000811)3.15393209
66regulation of cardioblast differentiation (GO:0051890)3.13580406
67focal adhesion assembly (GO:0048041)3.10265259
68cell-substrate adherens junction assembly (GO:0007045)3.10265259
69adherens junction assembly (GO:0034333)3.10224003
70positive regulation of osteoblast proliferation (GO:0033690)3.10029526
71neurotransmitter secretion (GO:0007269)3.08999611
72actin filament depolymerization (GO:0030042)3.08204224
73positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.07944917
74coenzyme catabolic process (GO:0009109)3.07680691
75activation of protein kinase A activity (GO:0034199)3.07405077
76negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.07386309
77mammary gland development (GO:0030879)3.06918963
78regulation of synaptic vesicle transport (GO:1902803)3.06826719
79sequestering of extracellular ligand from receptor (GO:0035581)3.06592041
80neural crest cell development (GO:0014032)3.06152503
81regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.04995995
82insulin secretion (GO:0030073)3.04960009
83melanosome transport (GO:0032402)3.03383741
84positive regulation of insulin secretion (GO:0032024)3.03329991
85maintenance of protein location in nucleus (GO:0051457)3.02421882
86stress granule assembly (GO:0034063)3.02085988
87stress fiber assembly (GO:0043149)3.01508802
88maintenance of protein localization in organelle (GO:0072595)2.99463077
89chondrocyte proliferation (GO:0035988)2.95665142
90cell junction assembly (GO:0034329)2.95318170
91maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.95024868
92collagen metabolic process (GO:0032963)2.94637792
93glutamate secretion (GO:0014047)2.94098882
94muscle cell migration (GO:0014812)2.93599354
95negative regulation of cartilage development (GO:0061037)2.93143731
96keratinocyte proliferation (GO:0043616)2.92426404
97positive regulation of hair follicle development (GO:0051798)2.92218972
98positive regulation of hair cycle (GO:0042635)2.92218972
99negative regulation of bone resorption (GO:0045779)2.91506654
100extracellular matrix disassembly (GO:0022617)2.90299535
101negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.89400605
102regulation of microtubule-based movement (GO:0060632)2.89071650
103synaptic vesicle exocytosis (GO:0016079)2.88327238
104negative regulation of stem cell proliferation (GO:2000647)2.87408208
105pyrimidine ribonucleoside catabolic process (GO:0046133)2.87143897
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86629598
107adaptation of signaling pathway (GO:0023058)2.86576529
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86407575
109neurotransmitter transport (GO:0006836)2.86394170
110chondrocyte development (GO:0002063)2.86268845
111surfactant homeostasis (GO:0043129)2.86164773
112glomerular basement membrane development (GO:0032836)2.85722649
113cytidine metabolic process (GO:0046087)2.83591061
114cytidine catabolic process (GO:0006216)2.83591061
115cytidine deamination (GO:0009972)2.83591061
116plasma membrane repair (GO:0001778)2.83314362
117collagen catabolic process (GO:0030574)2.82991033
118cellular modified amino acid catabolic process (GO:0042219)2.82971029
119pigment granule transport (GO:0051904)2.82774394
120endothelial cell morphogenesis (GO:0001886)2.82469579
121establishment of protein localization to Golgi (GO:0072600)2.82115170
122activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.81460570
123regulation of insulin secretion (GO:0050796)2.80715207
124glandular epithelial cell development (GO:0002068)2.80463861
125aminoglycoside antibiotic metabolic process (GO:0030647)2.80241080
126multicellular organismal macromolecule metabolic process (GO:0044259)2.80117729
127regulation of calcium ion-dependent exocytosis (GO:0017158)2.79786614
128negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.79638381
129establishment of melanosome localization (GO:0032401)2.79280658
130peptide hormone processing (GO:0016486)2.78287395
131negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.76915147
132primitive streak formation (GO:0090009)2.76699793
133cell junction organization (GO:0034330)2.76584201
134protein localization to cell surface (GO:0034394)2.75907153
135retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.75438156
136endocrine pancreas development (GO:0031018)2.74308409
137muscle organ morphogenesis (GO:0048644)2.73548969
138regulation of Golgi to plasma membrane protein transport (GO:0042996)2.72521066
139locomotory exploration behavior (GO:0035641)2.72305846
140cytoskeletal anchoring at plasma membrane (GO:0007016)2.72115596
141mitochondrial DNA metabolic process (GO:0032042)2.71838133
142cholesterol catabolic process (GO:0006707)2.71128550
143sterol catabolic process (GO:0016127)2.71128550
144positive regulation of peptide hormone secretion (GO:0090277)2.70926886
145wound healing (GO:0042060)2.70849211
146regulation of type B pancreatic cell apoptotic process (GO:2000674)2.70530205
147quinone metabolic process (GO:1901661)2.70452758
148substrate adhesion-dependent cell spreading (GO:0034446)2.68694231
149positive regulation of vesicle fusion (GO:0031340)2.67887392
150pathway-restricted SMAD protein phosphorylation (GO:0060389)2.67723434
151cerebellar Purkinje cell layer development (GO:0021680)2.67303111
152regulation of MHC class I biosynthetic process (GO:0045343)2.66326014
153regulation of transforming growth factor beta production (GO:0071634)2.66306524
154retina vasculature morphogenesis in camera-type eye (GO:0061299)2.66091071
155positive regulation of peptide secretion (GO:0002793)2.65337297
156multicellular organismal metabolic process (GO:0044236)2.63747708
157positive regulation of nuclease activity (GO:0032075)2.63175789
158retinal rod cell development (GO:0046548)2.62938259
159blood vessel endothelial cell migration (GO:0043534)2.62403729
160regulation of hippo signaling (GO:0035330)2.62377251
161regulation of anoikis (GO:2000209)2.62084765
162mammary gland epithelial cell proliferation (GO:0033598)2.61483450
163establishment of pigment granule localization (GO:0051905)2.60703694
164positive regulation of epithelial cell migration (GO:0010634)2.60140789
165apoptotic cell clearance (GO:0043277)2.59942302
166planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59664087
167response to vitamin D (GO:0033280)2.59072984
168serotonin metabolic process (GO:0042428)2.58873649
169regulation of peptide hormone secretion (GO:0090276)2.58758568
170regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.56267979
171regulation of peptide secretion (GO:0002791)2.55563076
172histone H4-K12 acetylation (GO:0043983)2.54835850
173melanosome localization (GO:0032400)2.54825069
174extracellular matrix organization (GO:0030198)2.54447667
175protein maturation by protein folding (GO:0022417)2.54361619
176extracellular fibril organization (GO:0043206)2.54348192
177positive regulation of astrocyte differentiation (GO:0048711)2.53967195
178extracellular structure organization (GO:0043062)2.53835790
179extracellular matrix assembly (GO:0085029)2.53628251
180positive regulation of endothelial cell migration (GO:0010595)2.53170010
181protein retention in ER lumen (GO:0006621)2.51962180
182regulation of neuron projection regeneration (GO:0070570)2.51615691
183regulation of axon regeneration (GO:0048679)2.51615691
184peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.50756741
185retrograde transport, vesicle recycling within Golgi (GO:0000301)2.50545658
186GDP-mannose metabolic process (GO:0019673)2.50228813
187negative regulation of protein oligomerization (GO:0032460)2.50134654
188COPII vesicle coating (GO:0048208)2.46976073
189regulation of neurotransmitter levels (GO:0001505)2.46804115
190exocrine pancreas development (GO:0031017)2.46370840
191cellular response to glucagon stimulus (GO:0071377)2.45473053
192hemidesmosome assembly (GO:0031581)10.3956929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.33352071
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.67049860
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.92309966
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.92309966
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.92309966
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.86459104
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.14802526
8SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.09833599
9SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.09833599
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96408581
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.95422388
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.45499177
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.42149799
14CLOCK_20551151_ChIP-Seq_293T_Human2.39263839
15CJUN_26792858_Chip-Seq_BT549_Human2.37936614
16REST_21632747_ChIP-Seq_MESCs_Mouse2.37649431
17IGF1R_20145208_ChIP-Seq_DFB_Human2.34910898
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.33308194
19* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.28951970
20* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.27212589
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.25513554
22PPAR_26484153_Chip-Seq_NCI-H1993_Human2.23756456
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.21517499
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20506628
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16939744
26GATA1_22025678_ChIP-Seq_K562_Human2.14046080
27* BRD4_25478319_ChIP-Seq_HGPS_Human2.12841522
28ESR1_21235772_ChIP-Seq_MCF-7_Human2.07118004
29ZNF263_19887448_ChIP-Seq_K562_Human2.00700956
30EZH2_22144423_ChIP-Seq_EOC_Human2.00684464
31TP63_17297297_ChIP-ChIP_HaCaT_Human10.4709056
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99350215
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96704501
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96235564
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93584693
36SOX9_24532713_ChIP-Seq_HFSC_Mouse1.91092822
37* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89117882
38* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.85871942
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85377338
40* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85213669
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82984880
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.81502464
43* UBF1/2_26484160_Chip-Seq_HMECs_Human1.80442228
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.80089051
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.79486394
46* ELK3_25401928_ChIP-Seq_HUVEC_Human1.78032010
47* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.76509302
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.72515361
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.70791797
50JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70627418
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.67981570
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.67538132
53* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65960919
54ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.63654728
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62928894
56* ATF3_27146783_Chip-Seq_COLON_Human1.62060045
57* KDM2B_26808549_Chip-Seq_K562_Human1.61799539
58* TP53_18474530_ChIP-ChIP_U2OS_Human1.61366739
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61047845
60RXR_22158963_ChIP-Seq_LIVER_Mouse1.60967539
61AR_21909140_ChIP-Seq_LNCAP_Human1.59275637
62SOX2_20726797_ChIP-Seq_SW620_Human1.59272386
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.57895454
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57588881
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56676946
66TP53_22127205_ChIP-Seq_IMR90_Human1.56547249
67* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55853120
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55836372
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55800781
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55365180
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54696306
72* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.51996748
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49152143
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.49024037
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46792623
76* FOXO3_23340844_ChIP-Seq_DLD1_Human1.46228514
77* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.44917842
78* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.44624404
79MYC_22102868_ChIP-Seq_BL_Human1.44136144
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44010983
81FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.43819932
82RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42723699
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42723699
84LXR_22158963_ChIP-Seq_LIVER_Mouse1.40918013
85* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40051952
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39150137
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38280456
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37590766
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35838589
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.34757177
91FOXM1_23109430_ChIP-Seq_U2OS_Human1.31543938
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.31402741
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30926324
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30926324
95* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30618126
96LXR_22292898_ChIP-Seq_THP-1_Human1.30162735
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.30137729
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.28406698
99* SMC4_20622854_ChIP-Seq_HELA_Human1.28097275
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26049039
101EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25235387
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24921436
103* RACK7_27058665_Chip-Seq_MCF-7_Human1.24181750
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23887950
105RING1B_27294783_Chip-Seq_NPCs_Mouse1.23474528
106* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21344920
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21149527
108RNF2_27304074_Chip-Seq_ESCs_Mouse1.20893783
109PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17310494
110IRF1_19129219_ChIP-ChIP_H3396_Human1.15447977
111SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14860054
112SCL_19346495_ChIP-Seq_HPC-7_Human1.14448320
113MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14193534
114* TP63_23658742_ChIP-Seq_EP156T_Human1.14000299
115E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13629584
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13454426
117DROSHA_22980978_ChIP-Seq_HELA_Human1.12870035
118* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12823607
119TET1_21490601_ChIP-Seq_MESCs_Mouse1.12384818
120JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12012567
121NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11266883
122TP53_16413492_ChIP-PET_HCT116_Human1.11244728
123ERG_21242973_ChIP-ChIP_JURKAT_Human1.10325904
124SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09528716
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08143791
126PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07972956
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07879713
128NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07718408
129CREB1_26743006_Chip-Seq_LNCaP_Human1.06460382
130TCF7_22412390_ChIP-Seq_EML_Mouse1.06253227
131AHR_22903824_ChIP-Seq_MCF-7_Human1.06176211
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05929194
133* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05861594
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05705279
135* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05616811
136AR_19668381_ChIP-Seq_PC3_Human1.05446107
137SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05039720
138TBX20_22080862_ChIP-Seq_HEART_Mouse1.04977190
139TBX20_22328084_ChIP-Seq_HEART_Mouse1.04977190
140SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04845536
141ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04766383
142EZH2_27304074_Chip-Seq_ESCs_Mouse1.03737018
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03526056
144DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02983532
145KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02834397
146NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01700472
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01478702
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99879169
149SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99423199
150EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98595979
151RING1B_27294783_Chip-Seq_ESCs_Mouse0.98392907
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98045231
153TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97673167
154KDM2B_26808549_Chip-Seq_DND41_Human0.97361250
155FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.97250082
156CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96633008
157ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96568766
158WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96531417
159TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96373798
160CDX2_20551321_ChIP-Seq_CACO-2_Human0.95466831
161NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94960431
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.93655655
163SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93388194
164TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93275717
165NCOR1_26117541_ChIP-Seq_K562_Human0.93249509
166CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92779049
167KLF5_25053715_ChIP-Seq_YYC3_Human0.92486821
168TP53_23651856_ChIP-Seq_MEFs_Mouse0.91964876
169EOMES_21245162_ChIP-Seq_HESCs_Human0.90949324
170ESR2_21235772_ChIP-Seq_MCF-7_Human0.90680235
171ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90011385
172ELF1_20517297_ChIP-Seq_JURKAT_Human0.89797963
173BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89343099
174PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88964615
175SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88876285
176Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88421397
177NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88414548
178SOX2_21211035_ChIP-Seq_LN229_Gbm0.88392887
179TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87596641
180NANOG_16518401_ChIP-PET_MESCs_Mouse0.86877964
181* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86114652
182GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85058552
183RUNX1_27514584_Chip-Seq_MCF-7_Human0.84529778
184CTCF_27219007_Chip-Seq_Bcells_Human0.84376111
185ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83992112
186ELK1_22589737_ChIP-Seq_MCF10A_Human0.80049096
187NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78490717
188PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77026662
189SA1_22415368_ChIP-Seq_MEFs_Mouse0.74193136
190* GATA3_24758297_ChIP-Seq_MCF-7_Human0.72678601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting5.09471782
2MP0008438_abnormal_cutaneous_collagen5.05138854
3MP0003566_abnormal_cell_adhesion4.46039258
4MP0004272_abnormal_basement_membrane4.14674572
5MP0002909_abnormal_adrenal_gland4.02334620
6MP0003705_abnormal_hypodermis_morpholog3.75629484
7MP0000579_abnormal_nail_morphology3.68097137
8MP0005275_abnormal_skin_tensile3.37531940
9MP0005623_abnormal_meninges_morphology3.25563445
10MP0004264_abnormal_extraembryonic_tissu3.24583967
11MP0003011_delayed_dark_adaptation3.16478925
12MP0004043_abnormal_pH_regulation2.80668330
13MP0003787_abnormal_imprinting2.74873749
14MP0002254_reproductive_system_inflammat2.74156997
15MP0003283_abnormal_digestive_organ2.74037335
16MP0008961_abnormal_basal_metabolism2.69926842
17MP0003121_genomic_imprinting2.69522078
18MP0000537_abnormal_urethra_morphology2.60922287
19MP0000762_abnormal_tongue_morphology2.54610470
20MP0003183_abnormal_peptide_metabolism2.52074804
21MP0002060_abnormal_skin_morphology2.48560589
22MP0005023_abnormal_wound_healing2.43864032
23MP0005645_abnormal_hypothalamus_physiol2.43595852
24MP0006292_abnormal_olfactory_placode2.34331844
25MP0003091_abnormal_cell_migration2.33406586
26MP0001958_emphysema2.30260992
27MP0002877_abnormal_melanocyte_morpholog2.28369515
28MP0006276_abnormal_autonomic_nervous2.26978821
29MP0000013_abnormal_adipose_tissue2.19184504
30MP0002139_abnormal_hepatobiliary_system2.17991195
31MP0009053_abnormal_anal_canal2.16891467
32MP0006072_abnormal_retinal_apoptosis2.13588170
33MP0003279_aneurysm2.11083318
34MP0001849_ear_inflammation2.08487370
35MP0010352_gastrointestinal_tract_polyps2.06074708
36MP0003941_abnormal_skin_development2.04608158
37MP0001944_abnormal_pancreas_morphology1.92422663
38MP0004858_abnormal_nervous_system1.90005781
39MP0010386_abnormal_urinary_bladder1.89663132
40MP0009384_cardiac_valve_regurgitation1.80828807
41MP0000467_abnormal_esophagus_morphology1.78963535
42MP0005248_abnormal_Harderian_gland1.75478653
43MP0005253_abnormal_eye_physiology1.75260413
44MP0001501_abnormal_sleep_pattern1.75222388
45MP0005551_abnormal_eye_electrophysiolog1.72951991
46MP0003950_abnormal_plasma_membrane1.72275670
47MP0004270_analgesia1.71932468
48MP0002693_abnormal_pancreas_physiology1.71767456
49MP0005535_abnormal_body_temperature1.71083906
50MP0006035_abnormal_mitochondrial_morpho1.70829796
51MP0005646_abnormal_pituitary_gland1.70598017
52MP0003890_abnormal_embryonic-extraembry1.68001811
53MP0003635_abnormal_synaptic_transmissio1.67420676
54MP0003453_abnormal_keratinocyte_physiol1.63544286
55MP0003123_paternal_imprinting1.63055557
56MP0009780_abnormal_chondrocyte_physiolo1.58412638
57MP0005499_abnormal_olfactory_system1.56246069
58MP0005394_taste/olfaction_phenotype1.56246069
59MP0002078_abnormal_glucose_homeostasis1.54414701
60MP0002733_abnormal_thermal_nociception1.54169128
61MP0006054_spinal_hemorrhage1.51455297
62MP0005379_endocrine/exocrine_gland_phen1.50918042
63MP0005409_darkened_coat_color1.49981969
64MP0000767_abnormal_smooth_muscle1.48729332
65MP0002638_abnormal_pupillary_reflex1.48306341
66MP0010368_abnormal_lymphatic_system1.46580273
67MP0001216_abnormal_epidermal_layer1.41807697
68MP0005501_abnormal_skin_physiology1.39967533
69MP0008875_abnormal_xenobiotic_pharmacok1.39890904
70MP0002796_impaired_skin_barrier1.38159050
71MP0010678_abnormal_skin_adnexa1.37669823
72MP0002572_abnormal_emotion/affect_behav1.37391215
73MP0001879_abnormal_lymphatic_vessel1.36416273
74MP0004859_abnormal_synaptic_plasticity1.36011247
75MP0000383_abnormal_hair_follicle1.35859689
76MP0005076_abnormal_cell_differentiation1.34323384
77MP0000733_abnormal_muscle_development1.32957274
78MP0002896_abnormal_bone_mineralization1.31142433
79MP0000534_abnormal_ureter_morphology1.30181567
80MP0005365_abnormal_bile_salt1.28738575
81MP0005167_abnormal_blood-brain_barrier1.25320995
82MP0002272_abnormal_nervous_system1.23686534
83MP0001243_abnormal_dermal_layer1.23469038
84MP0010771_integument_phenotype1.23180312
85MP0005197_abnormal_uvea_morphology1.21473853
86MP0002064_seizures1.20231117
87MP0003172_abnormal_lysosome_physiology1.19998665
88MP0002090_abnormal_vision1.19006294
89MP0009046_muscle_twitch1.18789717
90MP0000678_abnormal_parathyroid_gland1.18063888
91MP0003195_calcinosis1.17971128
92MP0002332_abnormal_exercise_endurance1.16962558
93MP0000627_abnormal_mammary_gland1.16509564
94MP0002734_abnormal_mechanical_nocicepti1.16075683
95MP0003300_gastrointestinal_ulcer1.14894881
96MP0002063_abnormal_learning/memory/cond1.14768084
97MP0003252_abnormal_bile_duct1.14729160
98MP0003191_abnormal_cellular_cholesterol1.13323857
99MP0005257_abnormal_intraocular_pressure1.12850462
100MP0001348_abnormal_lacrimal_gland1.10691845
101MP0003755_abnormal_palate_morphology1.09770237
102MP0001299_abnormal_eye_distance/1.09374973
103MP0001502_abnormal_circadian_rhythm1.09300281
104MP0005508_abnormal_skeleton_morphology1.09290105
105MP0003868_abnormal_feces_composition1.07868126
106MP0005503_abnormal_tendon_morphology1.07440821
107MP0000955_abnormal_spinal_cord1.07293299
108MP0002970_abnormal_white_adipose1.06392493
109MP0005193_abnormal_anterior_eye1.05944694
110MP0000858_altered_metastatic_potential1.05402825
111MP0001542_abnormal_bone_strength1.03403118
112MP0002234_abnormal_pharynx_morphology1.03327848
113MP0002837_dystrophic_cardiac_calcinosis1.03049252
114MP0008260_abnormal_autophagy1.02669553
115MP0003315_abnormal_perineum_morphology1.02449098
116MP0009745_abnormal_behavioral_response1.01947764
117MP0005164_abnormal_response_to1.00426427
118MP0000639_abnormal_adrenal_gland1.00229424
119MP0002229_neurodegeneration1.00166430
120MP0009250_abnormal_appendicular_skeleto1.00083131
121MP0000462_abnormal_digestive_system0.99860951
122MP0010234_abnormal_vibrissa_follicle0.99196522
123MP0003633_abnormal_nervous_system0.98383890
124MP0003953_abnormal_hormone_level0.97598325
125MP0005423_abnormal_somatic_nervous0.95925419
126MP0003448_altered_tumor_morphology0.93953615
127MP0000631_abnormal_neuroendocrine_gland0.93150804
128MP0000003_abnormal_adipose_tissue0.92547878
129MP0005085_abnormal_gallbladder_physiolo0.92030519
130MP0001970_abnormal_pain_threshold0.91242110
131MP0003385_abnormal_body_wall0.91192904
132MP0004233_abnormal_muscle_weight0.91133297
133MP0004085_abnormal_heartbeat0.90866561
134MP0000750_abnormal_muscle_regeneration0.89631249
135MP0001968_abnormal_touch/_nociception0.89599314
136MP0006036_abnormal_mitochondrial_physio0.89299416
137MP0002282_abnormal_trachea_morphology0.88235651
138MP0002971_abnormal_brown_adipose0.88089224
139MP0002098_abnormal_vibrissa_morphology0.87145460
140MP0005621_abnormal_cell_physiology0.86120312
141MP0002184_abnormal_innervation0.85341309
142MP0010030_abnormal_orbit_morphology0.85261457
143MP0003959_abnormal_lean_body0.84203207
144MP0002928_abnormal_bile_duct0.83524775
145MP0000538_abnormal_urinary_bladder0.82432238
146MP0001661_extended_life_span0.81573801
147MP0004084_abnormal_cardiac_muscle0.81162971
148MP0005165_increased_susceptibility_to0.81008710
149MP0006138_congestive_heart_failure0.80220528
150MP0004134_abnormal_chest_morphology0.80210379
151MP0002557_abnormal_social/conspecific_i0.80072168
152MP0004885_abnormal_endolymph0.80021336
153MP0002177_abnormal_outer_ear0.78748007
154MP0003329_amyloid_beta_deposits0.77462889
155MP0001340_abnormal_eyelid_morphology0.77343216
156MP0001915_intracranial_hemorrhage0.77142490
157MP0005075_abnormal_melanosome_morpholog0.77083130
158MP0003935_abnormal_craniofacial_develop0.76656903
159MP0005452_abnormal_adipose_tissue0.76300602
160MP0003942_abnormal_urinary_system0.75895449
161MP0000428_abnormal_craniofacial_morphol0.75466585
162MP0001486_abnormal_startle_reflex0.75466341
163MP0004947_skin_inflammation0.74883178
164MP0002295_abnormal_pulmonary_circulatio0.74690255
165MP0002697_abnormal_eye_size0.74446887
166MP0004142_abnormal_muscle_tone0.74059121
167MP0000163_abnormal_cartilage_morphology0.74016818
168MP0000432_abnormal_head_morphology0.72765962
169MP0001614_abnormal_blood_vessel0.72713079
170MP0002067_abnormal_sensory_capabilities0.72189485
171MP0003937_abnormal_limbs/digits/tail_de0.72007389
172MP0002069_abnormal_eating/drinking_beha0.71998628
173MP0003880_abnormal_central_pattern0.71664469
174MP0005386_behavior/neurological_phenoty0.71592349
175MP0004924_abnormal_behavior0.71592349
176MP0005220_abnormal_exocrine_pancreas0.71528445
177MP0000377_abnormal_hair_follicle0.71270559
178MP0002127_abnormal_cardiovascular_syste0.71241497
179MP0001851_eye_inflammation0.70235398
180MP0002925_abnormal_cardiovascular_devel0.69801233
181MP0010329_abnormal_lipoprotein_level0.69740015
182MP0008932_abnormal_embryonic_tissue0.69085470
183MP0001881_abnormal_mammary_gland0.68628636
184MP0000230_abnormal_systemic_arterial0.67965950
185MP0001324_abnormal_eye_pigmentation0.67702984
186MP0005595_abnormal_vascular_smooth0.67656104
187MP0005448_abnormal_energy_balance0.67592168

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)6.87745940
2Premature rupture of membranes (HP:0001788)5.92417368
3Hyperinsulinemic hypoglycemia (HP:0000825)5.71053909
4Ragged-red muscle fibers (HP:0003200)5.19333059
5Milia (HP:0001056)5.06283991
6Protrusio acetabuli (HP:0003179)4.87099091
7Hypochromic microcytic anemia (HP:0004840)4.58281621
8Arterial tortuosity (HP:0005116)4.50294700
9Onycholysis (HP:0001806)4.47857384
10Progressive inability to walk (HP:0002505)4.45852231
11Fragile skin (HP:0001030)4.40808811
12Aortic dissection (HP:0002647)4.40804363
13Hepatoblastoma (HP:0002884)4.26305522
14Vascular tortuosity (HP:0004948)4.25542993
15Facial diplegia (HP:0001349)4.22645557
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.11501035
17Hypoglycemic seizures (HP:0002173)4.02810709
18Febrile seizures (HP:0002373)3.89786636
19Fragile nails (HP:0001808)3.89398469
20Failure to thrive in infancy (HP:0001531)3.75693427
21Abnormality of calcium-phosphate metabolism (HP:0100530)3.42257613
22Abnormality of the lower motor neuron (HP:0002366)3.38079050
23Bilateral microphthalmos (HP:0007633)3.33272517
24Plantar hyperkeratosis (HP:0007556)3.32340302
25Symptomatic seizures (HP:0011145)3.28156271
26Abnormal pancreas size (HP:0012094)3.25621704
27Ulnar bowing (HP:0003031)3.23060375
28Congenital stationary night blindness (HP:0007642)3.21362638
29Limb hypertonia (HP:0002509)3.13631745
30Nail dystrophy (HP:0008404)3.12808775
31Ketoacidosis (HP:0001993)3.09808652
32Thick nail (HP:0001805)3.09070595
33Aortic aneurysm (HP:0004942)3.08407391
34Abnormality of aromatic amino acid family metabolism (HP:0004338)3.08148012
35Multiple enchondromatosis (HP:0005701)3.06723421
36Osteolytic defects of the hand bones (HP:0009699)3.04072869
37Osteolytic defects of the phalanges of the hand (HP:0009771)3.04072869
38Selective tooth agenesis (HP:0001592)3.03811806
39Abnormality of the intrinsic pathway (HP:0010989)3.02236260
40Macroorchidism (HP:0000053)3.01414801
41Spondylolisthesis (HP:0003302)3.00371379
42Hypoglycemic coma (HP:0001325)2.98952868
43Abnormality of the heme biosynthetic pathway (HP:0010472)2.98819629
44Short nail (HP:0001799)2.97357846
45Wormian bones (HP:0002645)2.97078387
46Hypoplasia of the fovea (HP:0007750)2.96346921
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.96346921
48Cervical subluxation (HP:0003308)2.92835396
49Abnormality of oral frenula (HP:0000190)2.91916020
50Open mouth (HP:0000194)2.88317707
51Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.88246459
52Abnormality of endocrine pancreas physiology (HP:0012093)2.83920987
53Abnormality of the pancreatic islet cells (HP:0006476)2.83920987
54Inability to walk (HP:0002540)2.82804243
55Epileptic encephalopathy (HP:0200134)2.82276321
56Gout (HP:0001997)2.80722292
57Pterygium (HP:0001059)2.80484912
58Ankle contracture (HP:0006466)2.79716905
59Visual hallucinations (HP:0002367)2.79713062
60Bladder diverticulum (HP:0000015)2.79197378
61Skin nodule (HP:0200036)2.74918835
62Broad face (HP:0000283)2.72665749
63Pancreatic islet-cell hyperplasia (HP:0004510)2.71707039
64Vertebral compression fractures (HP:0002953)2.70940099
65Absent frontal sinuses (HP:0002688)2.67678644
66Mitral stenosis (HP:0001718)2.65065766
67Alopecia of scalp (HP:0002293)2.63658311
68Vertebral arch anomaly (HP:0008438)2.60538525
69Agitation (HP:0000713)2.58999006
70Atonic seizures (HP:0010819)2.58909536
71Hyperglycemia (HP:0003074)2.58596497
72Abnormality of the fovea (HP:0000493)2.56685423
73Ankyloglossia (HP:0010296)2.55022552
74Abnormality of nail color (HP:0100643)2.53554339
75Neoplasm of the heart (HP:0100544)2.46570243
76Ridged nail (HP:0001807)2.45680225
77Abnormality of dentin (HP:0010299)2.45501028
78Retinal atrophy (HP:0001105)2.44171025
79Blue sclerae (HP:0000592)2.43768094
80Natal tooth (HP:0000695)2.43145462
81Bowed forearm bones (HP:0003956)2.42073505
82Bowing of the arm (HP:0006488)2.42073505
83Osteomalacia (HP:0002749)2.40811365
84Increased mean platelet volume (HP:0011877)2.40462196
85Tetraplegia (HP:0002445)2.40112018
86Scotoma (HP:0000575)2.38949010
87Peritonitis (HP:0002586)2.37552843
88Aortic regurgitation (HP:0001659)2.37142579
89Soft skin (HP:0000977)2.36589936
90Shallow orbits (HP:0000586)2.34979159
91Irritability (HP:0000737)2.34709425
92Mitral valve prolapse (HP:0001634)2.34688416
93Status epilepticus (HP:0002133)2.34533886
94Hypoplasia of dental enamel (HP:0006297)2.34182592
95Cardiovascular calcification (HP:0011915)2.32114728
96Right ventricular cardiomyopathy (HP:0011663)2.31721533
97Central scotoma (HP:0000603)2.29755117
98Tibial bowing (HP:0002982)2.29587154
99Late onset (HP:0003584)2.25652745
100Menstrual irregularities (HP:0000858)2.25068700
101Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.21922317
102Dilatation of the ascending aorta (HP:0005111)2.21154604
103Hemiparesis (HP:0001269)2.19900533
104Papilledema (HP:0001085)2.18168231
105Abnormal ossification of hand bones (HP:0005921)2.17943099
106Abnormality of carpal bone ossification (HP:0006257)2.17413201
107Tachypnea (HP:0002789)2.17169402
108Absence seizures (HP:0002121)2.16904992
109Focal segmental glomerulosclerosis (HP:0000097)2.15685444
110Depression (HP:0000716)2.14036988
111Cerebral aneurysm (HP:0004944)2.13026919
112Generalized tonic-clonic seizures (HP:0002069)2.11723703
113Resting tremor (HP:0002322)2.10500648
114Radial bowing (HP:0002986)2.10475827
115Mitral regurgitation (HP:0001653)2.10055506
116Pendular nystagmus (HP:0012043)2.09861801
117Back pain (HP:0003418)2.08637152
118Horizontal nystagmus (HP:0000666)2.08429775
119Generalized hypotonia (HP:0001290)2.07834209
120Impaired pain sensation (HP:0007328)2.07262187
121Abnormality of pain sensation (HP:0010832)2.07262187
122Dialeptic seizures (HP:0011146)2.06585912
123Hypercortisolism (HP:0001578)2.06128746
124Abnormal platelet volume (HP:0011876)2.05421378
125Flat acetabular roof (HP:0003180)2.04839181
126Testicular atrophy (HP:0000029)2.03233768
127Dyschromatopsia (HP:0007641)2.02547593
128Ketosis (HP:0001946)2.02427085
129Pheochromocytoma (HP:0002666)2.01936903
130Genu recurvatum (HP:0002816)2.01504336
131Aplasia/Hypoplasia of the macula (HP:0008059)2.01398828
132Hand muscle atrophy (HP:0009130)2.01340241
133Volvulus (HP:0002580)2.00255249
134Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99212111
135Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99212111
136Generalized amyotrophy (HP:0003700)1.97757760
137Follicular hyperkeratosis (HP:0007502)1.96990740
138Palmoplantar hyperkeratosis (HP:0000972)1.96959697
139Tented upper lip vermilion (HP:0010804)1.95205352
140Neonatal short-limb short stature (HP:0008921)1.95125787
141Abnormal cartilage morphology (HP:0002763)1.94672748
142Spinal rigidity (HP:0003306)1.94393993
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92315109
144Broad metatarsal (HP:0001783)1.92305977
145Abnormality of the acetabulum (HP:0003170)1.91311696
146Aplasia/Hypoplasia affecting the retina (HP:0008061)1.88742523
147Insulin-resistant diabetes mellitus (HP:0000831)1.88542451
148Hyperparathyroidism (HP:0000843)1.88317419
149Trismus (HP:0000211)1.87213748
150Wrist flexion contracture (HP:0001239)1.85471019
151Hyperventilation (HP:0002883)1.84999208
152Bifid tongue (HP:0010297)1.84894535
153Vascular calcification (HP:0004934)1.84347707
154Palmar hyperkeratosis (HP:0010765)1.84049650
155Villous atrophy (HP:0011473)1.82298993
156Abnormality of small intestinal villus morphology (HP:0011472)1.82298993
157Abnormality of the distal phalanx of the thumb (HP:0009617)1.82269137
158Abnormal rod and cone electroretinograms (HP:0008323)1.81871957
159Cortical visual impairment (HP:0100704)1.81865671
160Adrenal overactivity (HP:0002717)1.81824307
161Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.81331108
162Vertebral hypoplasia (HP:0008417)1.81331108
163Focal seizures (HP:0007359)1.81239921
164Aortic valve stenosis (HP:0001650)1.81190059
165Abnormal blistering of the skin (HP:0008066)1.80960691
166Hyperacusis (HP:0010780)1.80566061
167Hypothermia (HP:0002045)1.80128580
168Decreased circulating renin level (HP:0003351)1.80040642
169Progressive muscle weakness (HP:0003323)1.79917168
170Elbow flexion contracture (HP:0002987)1.79488662
171Annular pancreas (HP:0001734)1.78914435
172Hydroureter (HP:0000072)1.77102404
173Delayed gross motor development (HP:0002194)1.76505539
174Abnormal delivery (HP:0001787)1.76024613
175Amyotrophic lateral sclerosis (HP:0007354)1.75568937
176Coxa vara (HP:0002812)1.75340978
177Bony spicule pigmentary retinopathy (HP:0007737)1.75253182
178Supranuclear gaze palsy (HP:0000605)1.74984281
179Abnormality of the distal phalanges of the toes (HP:0010182)1.74744885
180Abnormality of the umbilical cord (HP:0010881)1.74606864
181Rhizomelia (HP:0008905)1.73452619
182Difficulty climbing stairs (HP:0003551)1.72737585
183EMG: neuropathic changes (HP:0003445)1.72605836
184Type II diabetes mellitus (HP:0005978)1.72139938
185Deviation of the thumb (HP:0009603)1.71233287
186Abnormal pupillary function (HP:0007686)1.70266177
187Joint laxity (HP:0001388)1.70158010
188Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.70153496
189Dysautonomia (HP:0002459)1.69255949
190Interstitial pulmonary disease (HP:0006530)1.67465244
191Abnormality of the frontal sinuses (HP:0002687)1.67449035
192Glomerulosclerosis (HP:0000096)1.66797726
193Short humerus (HP:0005792)1.65996249
194Fused cervical vertebrae (HP:0002949)1.64486639
195Hoarse voice (HP:0001609)1.64010015
196Advanced eruption of teeth (HP:0006288)1.63998948
197Distal upper limb amyotrophy (HP:0007149)1.62808513
198Upper limb amyotrophy (HP:0009129)1.62808513
199Mesomelia (HP:0003027)1.60344229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.37911978
2ERN14.00247655
3CDK123.94687727
4GRK53.79997761
5EPHA23.79662987
6TTN3.77523124
7EPHB23.37051752
8MET3.14628739
9NTRK32.91881918
10NTRK12.82413262
11HIPK22.77081472
12GRK62.69657639
13TESK12.65512709
14GRK12.61974373
15MYLK2.51505718
16INSRR2.46414082
17PAK42.45033927
18IRAK32.44588288
19FGFR32.31263673
20LIMK12.29619853
21SIK12.15581654
22LATS22.05252638
23TGFBR22.03828272
24WNK11.95315531
25ADRBK21.83676524
26MAP3K91.82519155
27MAP2K41.80250084
28NME21.76325983
29ERBB41.75189778
30LMTK21.69860729
31PASK1.65198724
32PRKD31.61607740
33PAK21.60367069
34NEK91.58183092
35ARAF1.58067588
36WNK31.56840886
37TRPM71.55036543
38PRKCH1.55030479
39MAPK71.54532060
40GRK71.46510408
41CAMKK21.38060103
42MAPK151.35999368
43CSF1R1.33533568
44UHMK11.31927211
45LATS11.28683083
46PDGFRA1.26473856
47ILK1.25365959
48MATK1.21143920
49TYRO31.21032359
50PIM21.20479488
51PRKG21.20395540
52DYRK1A1.19812836
53TAOK31.18623157
54BMX1.17885675
55SCYL21.15108718
56MARK21.13567646
57AKT31.11797394
58NTRK21.10296308
59DDR21.10003430
60MAP3K121.07426584
61ROCK21.06030760
62ADRBK11.03592589
63MAPKAPK31.03234084
64MELK1.03223345
65STK101.02858062
66EPHB11.02161046
67ALK1.01987078
68FLT31.01782604
69MAP3K11.01263583
70MOS0.99984066
71EIF2AK10.99192436
72SIK20.98817087
73KSR10.97658709
74DYRK1B0.97564569
75PTK20.93369341
76PDGFRB0.93222192
77TIE10.89376568
78CAMKK10.89301805
79PAK30.88778397
80ROCK10.87013865
81CAMK40.84034404
82STK380.83576409
83RIPK10.83007342
84MAP3K70.82852439
85FGFR40.82128901
86MAP3K40.81589953
87WNK40.80255094
88CDC42BPA0.79458527
89PRKD20.77368556
90MAP3K30.72753481
91MAP3K20.72714550
92SIK30.72438036
93PAK60.71610478
94MINK10.70844687
95MAPK120.67401030
96RET0.67048167
97ABL20.67034003
98MUSK0.65814566
99TNK20.64476997
100CDK50.63467637
101TAOK10.62870312
102MAP3K80.62625623
103PRKCG0.62416742
104SGK30.61326188
105DMPK0.61165837
106JAK10.60557548
107JAK20.59436500
108RPS6KA20.59366561
109CAMK2G0.58470876
110CDK80.58264962
111TRIB30.58049787
112CAMK1G0.57916060
113IGF1R0.57872676
114BRSK10.57083693
115DAPK30.56237615
116STK30.56214078
117MAP3K100.55696326
118CAMK2B0.54175180
119PRKACG0.53067167
120EPHA30.52882283
121KSR20.52180452
122PKN20.52028438
123PDK10.51476093
124STK38L0.51221600
125PAK10.50141036
126PBK0.49966033
127LRRK20.49853035
128PRPF4B0.49771396
129BCKDK0.47950087
130CSK0.47881647
131ITK0.47731348
132RPS6KB20.47668071
133PIK3CA0.47181501
134PIK3CG0.46169546
135FRK0.46141929
136CLK10.46019851
137BRSK20.45988394
138PRKAA10.45879694
139MAP2K10.44123656
140SMG10.43899665
141MAPKAPK20.43761182
142GSK3A0.43727712
143RPS6KA30.43633439
144PTK2B0.43350340
145MAPK100.43327940
146MARK10.40945870
147STK240.39021321
148TAOK20.39014054
149CAMK10.38888187
150PRKCE0.37436686
151PRKD10.36609547
152PRKACA0.36601532
153NEK10.36147881
154INSR0.36116040
155PTK60.36003315
156CAMK1D0.35947774
157FER0.35518625
158KDR0.34595209
159ICK0.34015492
160MAP3K60.33479369
161AURKA0.33152668
162ERBB30.32619809
163MAP2K60.30926013
164IRAK10.30830632
165CAMK2D0.30743559
166SGK20.30634596
167ZAP700.28868686
168TGFBR10.28609615
169CSNK1G20.28391827
170CDK60.27750704
171AURKB0.27565629
172MTOR0.26898064

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.07581174
2ECM-receptor interaction_Homo sapiens_hsa045124.38474444
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.70316925
4Focal adhesion_Homo sapiens_hsa045103.01876509
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.97034707
6Small cell lung cancer_Homo sapiens_hsa052222.84003815
7Insulin secretion_Homo sapiens_hsa049112.79758225
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.77652027
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.55725807
10GABAergic synapse_Homo sapiens_hsa047272.42222254
11Taste transduction_Homo sapiens_hsa047422.31614308
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30636175
13Adherens junction_Homo sapiens_hsa045202.26138513
14Proteoglycans in cancer_Homo sapiens_hsa052052.17833679
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.15469594
16Amoebiasis_Homo sapiens_hsa051462.09773206
17Synaptic vesicle cycle_Homo sapiens_hsa047212.09385934
18Dilated cardiomyopathy_Homo sapiens_hsa054141.89361091
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.86158257
20Regulation of actin cytoskeleton_Homo sapiens_hsa048101.84996026
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.84428586
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.83481262
23Protein export_Homo sapiens_hsa030601.79818315
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78075516
25Tryptophan metabolism_Homo sapiens_hsa003801.75084879
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72687358
27Hippo signaling pathway_Homo sapiens_hsa043901.70317474
28Nitrogen metabolism_Homo sapiens_hsa009101.67182911
29Serotonergic synapse_Homo sapiens_hsa047261.65931003
30Cocaine addiction_Homo sapiens_hsa050301.64317247
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.62748202
32Bladder cancer_Homo sapiens_hsa052191.61055641
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.60196042
34Nicotine addiction_Homo sapiens_hsa050331.56382303
35Galactose metabolism_Homo sapiens_hsa000521.55955434
36TGF-beta signaling pathway_Homo sapiens_hsa043501.53598116
37Type II diabetes mellitus_Homo sapiens_hsa049301.50186846
38Selenocompound metabolism_Homo sapiens_hsa004501.49146499
39Shigellosis_Homo sapiens_hsa051311.46856152
40MicroRNAs in cancer_Homo sapiens_hsa052061.42577231
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42452508
42Circadian entrainment_Homo sapiens_hsa047131.40762221
43Chronic myeloid leukemia_Homo sapiens_hsa052201.40729090
44Glutamatergic synapse_Homo sapiens_hsa047241.38587453
45Morphine addiction_Homo sapiens_hsa050321.37832507
46Fructose and mannose metabolism_Homo sapiens_hsa000511.37733859
47Pancreatic cancer_Homo sapiens_hsa052121.36507776
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31304709
49Amphetamine addiction_Homo sapiens_hsa050311.29438897
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28927143
51Dopaminergic synapse_Homo sapiens_hsa047281.28120117
52Bile secretion_Homo sapiens_hsa049761.25095707
53PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24826754
54p53 signaling pathway_Homo sapiens_hsa041151.24246684
55Long-term potentiation_Homo sapiens_hsa047201.22853362
56Vibrio cholerae infection_Homo sapiens_hsa051101.22817311
57Renal cell carcinoma_Homo sapiens_hsa052111.20153101
58Pathways in cancer_Homo sapiens_hsa052001.18885109
59ABC transporters_Homo sapiens_hsa020101.12033038
60Protein digestion and absorption_Homo sapiens_hsa049741.11946989
61Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11223302
62Sulfur metabolism_Homo sapiens_hsa009201.08258167
63Leukocyte transendothelial migration_Homo sapiens_hsa046701.07102223
64Cholinergic synapse_Homo sapiens_hsa047251.06938199
65Renin secretion_Homo sapiens_hsa049241.05768134
66Pentose phosphate pathway_Homo sapiens_hsa000301.03646509
67Tight junction_Homo sapiens_hsa045301.02677776
68mTOR signaling pathway_Homo sapiens_hsa041501.01418076
69Salivary secretion_Homo sapiens_hsa049701.01324226
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98650601
71Circadian rhythm_Homo sapiens_hsa047100.97884604
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97375997
73ErbB signaling pathway_Homo sapiens_hsa040120.96851548
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.96572926
75Melanoma_Homo sapiens_hsa052180.96089191
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.94158269
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94147872
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93399178
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93094891
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92564637
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92455539
82Malaria_Homo sapiens_hsa051440.92424878
83Steroid biosynthesis_Homo sapiens_hsa001000.91254110
84Endocytosis_Homo sapiens_hsa041440.91103646
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90171448
86Vitamin B6 metabolism_Homo sapiens_hsa007500.89106243
87Toxoplasmosis_Homo sapiens_hsa051450.87883931
88Axon guidance_Homo sapiens_hsa043600.87426597
89Phototransduction_Homo sapiens_hsa047440.87384844
90Olfactory transduction_Homo sapiens_hsa047400.86226391
91Salmonella infection_Homo sapiens_hsa051320.85395851
92Phenylalanine metabolism_Homo sapiens_hsa003600.83552612
93Linoleic acid metabolism_Homo sapiens_hsa005910.83262026
94Thyroid hormone synthesis_Homo sapiens_hsa049180.83107187
95Insulin resistance_Homo sapiens_hsa049310.82860884
96Glucagon signaling pathway_Homo sapiens_hsa049220.80920027
97Glioma_Homo sapiens_hsa052140.80367401
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79638059
99Butanoate metabolism_Homo sapiens_hsa006500.79637374
100Inositol phosphate metabolism_Homo sapiens_hsa005620.79327910
101Type I diabetes mellitus_Homo sapiens_hsa049400.79128270
102Basal cell carcinoma_Homo sapiens_hsa052170.76032647
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75702525
104Notch signaling pathway_Homo sapiens_hsa043300.74948506
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.74324885
106Hedgehog signaling pathway_Homo sapiens_hsa043400.73475561
107Ovarian steroidogenesis_Homo sapiens_hsa049130.73459894
108cAMP signaling pathway_Homo sapiens_hsa040240.73386272
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.72867984
110Starch and sucrose metabolism_Homo sapiens_hsa005000.72692175
111Prion diseases_Homo sapiens_hsa050200.72246795
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.72097304
113Long-term depression_Homo sapiens_hsa047300.72038813
114Tyrosine metabolism_Homo sapiens_hsa003500.71816636
115Prostate cancer_Homo sapiens_hsa052150.71670372
116TNF signaling pathway_Homo sapiens_hsa046680.70841398
117GnRH signaling pathway_Homo sapiens_hsa049120.69067341
118Apoptosis_Homo sapiens_hsa042100.68617847
119Dorso-ventral axis formation_Homo sapiens_hsa043200.68345240
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.67861482
121Arginine biosynthesis_Homo sapiens_hsa002200.67122962
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66777843
123Estrogen signaling pathway_Homo sapiens_hsa049150.66045454
124Gastric acid secretion_Homo sapiens_hsa049710.65457570
125Rap1 signaling pathway_Homo sapiens_hsa040150.64107559
126Oxytocin signaling pathway_Homo sapiens_hsa049210.63809264
127Prolactin signaling pathway_Homo sapiens_hsa049170.63046619
128Pancreatic secretion_Homo sapiens_hsa049720.62793756
129Endometrial cancer_Homo sapiens_hsa052130.62767927
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60930178
131Choline metabolism in cancer_Homo sapiens_hsa052310.60486684
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59955681
133Viral carcinogenesis_Homo sapiens_hsa052030.59660672
134Calcium signaling pathway_Homo sapiens_hsa040200.59635277
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58989692
136VEGF signaling pathway_Homo sapiens_hsa043700.56334655
137Thyroid cancer_Homo sapiens_hsa052160.55455154
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.55318712
139Sphingolipid metabolism_Homo sapiens_hsa006000.54735070
140Platelet activation_Homo sapiens_hsa046110.54515005
141Folate biosynthesis_Homo sapiens_hsa007900.53053171
142HIF-1 signaling pathway_Homo sapiens_hsa040660.52023363
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.52016971
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51897821
145Wnt signaling pathway_Homo sapiens_hsa043100.51468719
146Collecting duct acid secretion_Homo sapiens_hsa049660.50723724
147Non-small cell lung cancer_Homo sapiens_hsa052230.50679263
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50337748
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50278818
150Complement and coagulation cascades_Homo sapiens_hsa046100.49318516
151AMPK signaling pathway_Homo sapiens_hsa041520.49158337
152Insulin signaling pathway_Homo sapiens_hsa049100.48530685
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47975081
154Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47620195
155Gap junction_Homo sapiens_hsa045400.45680512
156Hepatitis B_Homo sapiens_hsa051610.44929050
157Colorectal cancer_Homo sapiens_hsa052100.44760253
158Hepatitis C_Homo sapiens_hsa051600.44598154
159HTLV-I infection_Homo sapiens_hsa051660.44214966
160Melanogenesis_Homo sapiens_hsa049160.43005762
161Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42285256
162N-Glycan biosynthesis_Homo sapiens_hsa005100.40675474
163Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37277209
164Other glycan degradation_Homo sapiens_hsa005110.36777159
165Lysosome_Homo sapiens_hsa041420.36616531
166Central carbon metabolism in cancer_Homo sapiens_hsa052300.36565222
167Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35878930
168Cell cycle_Homo sapiens_hsa041100.31821562
169Phagosome_Homo sapiens_hsa041450.29394162
170FoxO signaling pathway_Homo sapiens_hsa040680.29222588
171Acute myeloid leukemia_Homo sapiens_hsa052210.26216982
172MAPK signaling pathway_Homo sapiens_hsa040100.24680884
173Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24637753
174Glutathione metabolism_Homo sapiens_hsa004800.23872058

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