AMIGO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)7.38458094
2negative regulation of dendrite morphogenesis (GO:0050774)6.39167767
3ribosomal small subunit assembly (GO:0000028)6.36153216
4detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.91334231
5detection of temperature stimulus involved in sensory perception (GO:0050961)5.91334231
6base-excision repair, AP site formation (GO:0006285)5.80359380
7detection of temperature stimulus (GO:0016048)5.70430592
8pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.68722155
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.58748245
10purine deoxyribonucleotide catabolic process (GO:0009155)5.54382275
11negative regulation of B cell apoptotic process (GO:0002903)5.35449004
12peripheral nervous system neuron development (GO:0048935)5.30306425
13deoxyribonucleotide catabolic process (GO:0009264)5.28864322
14ncRNA 3-end processing (GO:0043628)5.13343434
15deoxyribose phosphate catabolic process (GO:0046386)4.93804269
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.84287494
17NADH dehydrogenase complex assembly (GO:0010257)4.84287494
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.84287494
19pyrimidine nucleotide catabolic process (GO:0006244)4.82733714
20ubiquinone biosynthetic process (GO:0006744)4.81448890
21seminiferous tubule development (GO:0072520)4.71095860
22pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.68843481
23ubiquinone metabolic process (GO:0006743)4.42033339
24protein complex biogenesis (GO:0070271)4.40062634
25chaperone-mediated protein transport (GO:0072321)4.33642528
26protein maturation by protein folding (GO:0022417)4.33517235
27negative regulation of calcium ion transport into cytosol (GO:0010523)4.32420045
28mitochondrial respiratory chain complex assembly (GO:0033108)4.28181428
29neuronal action potential (GO:0019228)4.27799681
30viral transcription (GO:0019083)4.27544726
31establishment of protein localization to mitochondrial membrane (GO:0090151)4.20289619
322-deoxyribonucleotide metabolic process (GO:0009394)4.08226877
33ribosomal small subunit biogenesis (GO:0042274)4.05042239
34translational termination (GO:0006415)4.03574815
35negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.01440782
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.96362397
37ATP synthesis coupled proton transport (GO:0015986)3.86694768
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86694768
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.86493581
40bundle of His cell to Purkinje myocyte communication (GO:0086069)3.83602594
41deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.83483324
42quinone biosynthetic process (GO:1901663)3.83382923
43rRNA modification (GO:0000154)3.81152528
44sequestering of actin monomers (GO:0042989)3.78780365
45protein polyglutamylation (GO:0018095)3.78073313
46deoxyribose phosphate metabolic process (GO:0019692)3.76827189
47response to misfolded protein (GO:0051788)3.74862759
48cellular response to nicotine (GO:0071316)3.72344378
49plasma membrane repair (GO:0001778)3.67833173
50respiratory electron transport chain (GO:0022904)3.65686602
51regulation of translational termination (GO:0006449)3.64590452
52inner mitochondrial membrane organization (GO:0007007)3.62371205
53Golgi transport vesicle coating (GO:0048200)3.59613041
54COPI coating of Golgi vesicle (GO:0048205)3.59613041
55purine deoxyribonucleotide metabolic process (GO:0009151)3.58975887
56electron transport chain (GO:0022900)3.58594465
57translational elongation (GO:0006414)3.58149650
58purine ribonucleotide transport (GO:0015868)3.58105321
59maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54518140
60GDP-mannose metabolic process (GO:0019673)3.51194680
61negative regulation of dendrite development (GO:2000171)3.50239121
62negative regulation of cell cycle arrest (GO:0071157)3.48786349
63regulation of NFAT protein import into nucleus (GO:0051532)3.46211159
64autophagic vacuole fusion (GO:0000046)3.45038602
65regulation of glucose import in response to insulin stimulus (GO:2001273)3.43966390
66regulation of platelet aggregation (GO:0090330)3.43799759
67respiratory chain complex IV assembly (GO:0008535)3.43716398
68purine nucleotide salvage (GO:0032261)3.43359499
69cell migration in hindbrain (GO:0021535)3.41507211
70adenine nucleotide transport (GO:0051503)3.40674505
71DNA integration (GO:0015074)3.38652788
72membrane depolarization during action potential (GO:0086010)3.38218949
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.37841390
74meiotic chromosome segregation (GO:0045132)3.35928201
75cotranslational protein targeting to membrane (GO:0006613)3.32467583
76deoxyribonucleotide metabolic process (GO:0009262)3.30616266
77maturation of SSU-rRNA (GO:0030490)3.29826765
78intermediate filament organization (GO:0045109)3.28977859
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26375749
80activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.26258203
81L-fucose catabolic process (GO:0042355)3.25927610
82fucose catabolic process (GO:0019317)3.25927610
83L-fucose metabolic process (GO:0042354)3.25927610
84protein targeting to ER (GO:0045047)3.25608671
85negative regulation of bone resorption (GO:0045779)3.23886661
86protein retention in ER lumen (GO:0006621)3.21820587
87oxidative phosphorylation (GO:0006119)3.20864267
88peptidyl-histidine modification (GO:0018202)3.19869034
89membrane budding (GO:0006900)3.19205392
90cytochrome complex assembly (GO:0017004)3.17915187
91potassium ion export (GO:0071435)3.16794567
92protein localization to endoplasmic reticulum (GO:0070972)3.16587944
93ER overload response (GO:0006983)3.16510197
94cellular protein complex disassembly (GO:0043624)3.15325561
95behavioral response to pain (GO:0048266)3.15128981
96pseudouridine synthesis (GO:0001522)3.11552470
97protein-cofactor linkage (GO:0018065)3.11055796
98nucleoside transmembrane transport (GO:1901642)3.08664210
99regulation of Golgi to plasma membrane protein transport (GO:0042996)3.08638140
100positive regulation of nuclease activity (GO:0032075)3.08204650
101regulation of dopamine metabolic process (GO:0042053)3.06706944
102regulation of catecholamine metabolic process (GO:0042069)3.06706944
103nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04483146
104cell communication involved in cardiac conduction (GO:0086065)3.04112027
105adenosine metabolic process (GO:0046085)3.03870195
106activated T cell proliferation (GO:0050798)3.03046714
107negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.03010471
108establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02577950
109DNA damage response, detection of DNA damage (GO:0042769)3.01083431
110purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.00248107
111regulation of penile erection (GO:0060405)2.99678512
112aerobic respiration (GO:0009060)2.98720305
113actin filament capping (GO:0051693)2.98284898
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.97556413
115protein complex disassembly (GO:0043241)2.94113039
116misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.93915589
117nucleoside transport (GO:0015858)2.93139514
118modulation by virus of host process (GO:0019054)2.91246971
119phosphatidylglycerol biosynthetic process (GO:0006655)2.91012424
120exocrine pancreas development (GO:0031017)2.90932865
121response to ATP (GO:0033198)2.89643153
122transcription elongation from RNA polymerase III promoter (GO:0006385)2.87506935
123termination of RNA polymerase III transcription (GO:0006386)2.87506935
124negative regulation of homotypic cell-cell adhesion (GO:0034111)2.86273067
125DNA strand elongation involved in DNA replication (GO:0006271)2.85720576
126response to water (GO:0009415)2.85703583
127regulation of amyloid precursor protein catabolic process (GO:1902991)2.83750283
128base-excision repair (GO:0006284)2.83730254
129viral life cycle (GO:0019058)2.83407979
130intermediate filament cytoskeleton organization (GO:0045104)2.81790893
131intracellular protein transmembrane import (GO:0044743)2.81417195
132retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.81048637
133nucleotide salvage (GO:0043173)2.80106023
134positive regulation of prostaglandin secretion (GO:0032308)2.79217604
135intermediate filament-based process (GO:0045103)2.79076076
136antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77179026
137antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.77179026
138regulation of nuclease activity (GO:0032069)2.77133824
139proline transport (GO:0015824)2.76516794
140negative regulation of actin filament polymerization (GO:0030837)2.75194486
141secondary metabolite biosynthetic process (GO:0044550)2.74126437
142pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.74030489
143regulation of B cell apoptotic process (GO:0002902)2.73650611
144regulation of early endosome to late endosome transport (GO:2000641)2.72291749
145COPII vesicle coating (GO:0048208)2.69498560
146macromolecular complex disassembly (GO:0032984)2.69453172
147UV protection (GO:0009650)2.69362550
148endoplasmic reticulum unfolded protein response (GO:0030968)2.68306244
149DNA strand elongation (GO:0022616)2.66346094
150establishment of protein localization to mitochondrion (GO:0072655)2.65957577
151positive regulation of cardiac muscle hypertrophy (GO:0010613)2.65591681
152positive regulation of muscle hypertrophy (GO:0014742)2.65591681
153deoxyribose phosphate biosynthetic process (GO:0046385)2.64402145
1542-deoxyribonucleotide biosynthetic process (GO:0009265)2.64402145
155negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.64047042
156negative regulation of telomere maintenance (GO:0032205)2.63859278
157transcription from RNA polymerase I promoter (GO:0006360)2.63818534
158ER-nucleus signaling pathway (GO:0006984)2.63692558
159sodium ion transmembrane transport (GO:0035725)2.61708850
160membrane repolarization (GO:0086009)2.60354136
161negative regulation of complement activation (GO:0045916)2.60161335
162neuronal action potential propagation (GO:0019227)2.59959156
163response to pain (GO:0048265)2.59584267
164cellular response to unfolded protein (GO:0034620)2.57838065
165antigen processing and presentation of endogenous antigen (GO:0019883)2.54221365
166negative regulation of bone remodeling (GO:0046851)2.50555126
167cytidine metabolic process (GO:0046087)2.50148217
168cytidine catabolic process (GO:0006216)2.50148217
169cytidine deamination (GO:0009972)2.50148217
170calcium-mediated signaling using intracellular calcium source (GO:0035584)2.48813173
171insulin secretion (GO:0030073)2.45764477
172endoplasmic reticulum organization (GO:0007029)2.45499338
173intestinal epithelial cell development (GO:0060576)2.44775406
174neuron fate specification (GO:0048665)2.43599533
175sodium ion export (GO:0071436)2.43412628
176sensory perception of taste (GO:0050909)2.43218706
177negative regulation of protein polymerization (GO:0032272)2.42276918
178regulation of type B pancreatic cell apoptotic process (GO:2000674)2.42119486
179sequestering of metal ion (GO:0051238)2.41849074
180cellular response to topologically incorrect protein (GO:0035967)2.38983950
181regulation of histone phosphorylation (GO:0033127)2.38212790
182protoporphyrinogen IX metabolic process (GO:0046501)2.36504469
183pyrimidine ribonucleoside catabolic process (GO:0046133)2.36417007
184axon cargo transport (GO:0008088)2.35957440
185regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.33540760
186regulation of relaxation of muscle (GO:1901077)2.32237008
187regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.31763779
188negative regulation of protein activation cascade (GO:2000258)2.29580780
189cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.29539614
190positive regulation of steroid biosynthetic process (GO:0010893)2.29454467
191regulation of sodium ion transmembrane transporter activity (GO:2000649)2.28246923
192enteric nervous system development (GO:0048484)2.27467926
193ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.27216897
194glucose 6-phosphate metabolic process (GO:0051156)2.26686319
195antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.26652368
196neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.25469989
197low-density lipoprotein particle remodeling (GO:0034374)2.25382184
198antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.25002854
199positive thymic T cell selection (GO:0045059)2.24337688
200antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.24167152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.74165100
2GATA1_22025678_ChIP-Seq_K562_Human3.50386484
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.10723659
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01516557
5ZNF263_19887448_ChIP-Seq_K562_Human2.73158248
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71991002
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.71795685
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62572103
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.59320014
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57441607
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55042185
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53767272
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.48162869
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43657471
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.39654717
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.39592790
17XRN2_22483619_ChIP-Seq_HELA_Human2.36009725
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.35764724
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.26584593
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.25380410
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.24417582
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.23224386
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.19939973
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.18247266
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17486926
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07151330
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06501015
28BCL6_27268052_Chip-Seq_Bcells_Human2.05213590
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04648731
30E2F7_22180533_ChIP-Seq_HELA_Human2.00300259
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.96044377
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95453920
33P68_20966046_ChIP-Seq_HELA_Human1.92477697
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.90476230
35VDR_21846776_ChIP-Seq_THP-1_Human1.87069952
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86009854
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85710084
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84645882
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83485401
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83422979
41KDM2B_26808549_Chip-Seq_DND41_Human1.81437862
42GABP_19822575_ChIP-Seq_HepG2_Human1.81434361
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80522479
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80070927
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79594832
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77808223
47GATA1_19941826_ChIP-Seq_K562_Human1.76581926
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.76448119
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.76052399
50* ERG_21242973_ChIP-ChIP_JURKAT_Human1.75936141
51FOXP3_21729870_ChIP-Seq_TREG_Human1.75423108
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74887172
53KDM2B_26808549_Chip-Seq_K562_Human1.74406258
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.72403476
55EGR1_19032775_ChIP-ChIP_M12_Human1.72061341
56SPI1_23127762_ChIP-Seq_K562_Human1.71272103
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70972574
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69777727
59CIITA_25753668_ChIP-Seq_RAJI_Human1.69541796
60VDR_23849224_ChIP-Seq_CD4+_Human1.68121954
61* LXR_22292898_ChIP-Seq_THP-1_Human1.67754811
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.67338857
63BCOR_27268052_Chip-Seq_Bcells_Human1.67114582
64MYC_22102868_ChIP-Seq_BL_Human1.65857534
65GATA2_19941826_ChIP-Seq_K562_Human1.62952153
66FOXP1_21924763_ChIP-Seq_HESCs_Human1.60566598
67E2F1_20622854_ChIP-Seq_HELA_Human1.57624339
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57299325
69RUNX_20019798_ChIP-Seq_JUKART_Human1.56159632
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55493515
71TTF2_22483619_ChIP-Seq_HELA_Human1.55053250
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54880647
73* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.54685367
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54311272
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54294711
76* PHF8_20622854_ChIP-Seq_HELA_Human1.54189330
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53374113
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52833842
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52589812
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50346998
81RXR_22158963_ChIP-Seq_LIVER_Mouse1.49473163
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47602360
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47576551
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47522645
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47144845
86ATF3_27146783_Chip-Seq_COLON_Human1.45733542
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45420441
88YY1_22570637_ChIP-Seq_MALME-3M_Human1.44956862
89* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43861998
90GATA6_25053715_ChIP-Seq_YYC3_Human1.42515275
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42216793
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.42145376
93RACK7_27058665_Chip-Seq_MCF-7_Human1.41686085
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41168772
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40869473
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40038907
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39470436
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39439559
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39395153
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37802213
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.36768683
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36529819
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35141176
104* VDR_24763502_ChIP-Seq_THP-1_Human1.34280704
105CTCF_26484167_Chip-Seq_Bcells_Mouse1.34264920
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33855214
107FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33211575
108SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32745856
109FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32449779
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31781969
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31023028
112MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30706650
113KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.30250318
114CTCF_21964334_Chip-Seq_Bcells_Human1.29410277
115SA1_27219007_Chip-Seq_Bcells_Human1.29383149
116GATA2_21666600_ChIP-Seq_HMVEC_Human1.27387513
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27241306
118DCP1A_22483619_ChIP-Seq_HELA_Human1.27077359
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26424228
120* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26313340
121TCF7_22412390_ChIP-Seq_EML_Mouse1.26150217
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25816964
123SOX2_20726797_ChIP-Seq_SW620_Human1.25186905
124SMC4_20622854_ChIP-Seq_HELA_Human1.24671744
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24559228
126P300_27268052_Chip-Seq_Bcells_Human1.24409436
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23172681
128* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23022568
129RARB_24833708_ChIP-Seq_LIVER_Mouse1.22615049
130FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22600412
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21412366
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20477166
133CTCF_20526341_ChIP-Seq_ESCs_Human1.19466995
134CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19081508
135* MAF_26560356_Chip-Seq_TH1_Human1.18242578
136BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17321155
137MAF_26560356_Chip-Seq_TH2_Human1.16677748
138MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16294327
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15969289
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15847559
141IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14920179
142FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14884301
143SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14760062
144SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14221580
145SPI1_20517297_ChIP-Seq_HL60_Human1.13411760
146SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13173079
147IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13113493
148GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12666218
149ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12430848
150GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11694825
151CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11009445
152LXR_22158963_ChIP-Seq_LIVER_Mouse1.10763440
153CTCF_27219007_Chip-Seq_Bcells_Human1.10139103
154ERA_21632823_ChIP-Seq_H3396_Human1.09988283
155E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09610137
156IRF1_19129219_ChIP-ChIP_H3396_Human1.09027471
157POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08842392
158GATA3_27048872_Chip-Seq_THYMUS_Human1.08604692
159SMAD_19615063_ChIP-ChIP_OVARY_Human1.08410149
160IRF8_27001747_Chip-Seq_BMDM_Mouse1.07641233
161EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07474405
162SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06891897
163PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06614080
164RUNX1_22412390_ChIP-Seq_EML_Mouse1.06219205
165CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05998512
166SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05158593
167* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04994758
168ELF1_20517297_ChIP-Seq_JURKAT_Human1.04264115
169UTX_26944678_Chip-Seq_JUKART_Human1.03863781
170STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02142418
171NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01809224
172PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01477259
173NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99438491
174MYB_26560356_Chip-Seq_TH2_Human0.99057187
175SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98216441
176ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97817739
177RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95851701
178Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95779118
179STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95442206
180CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94856367
181RUNX1_27514584_Chip-Seq_MCF-7_Human0.93365225
182BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93223957
183* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93222841
184RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92680746
185CREB1_26743006_Chip-Seq_LNCaP_Human0.91334437
186VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89136191
187ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88759084
188FOXO3_23340844_ChIP-Seq_DLD1_Human0.87164285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception6.30052162
2MP0002736_abnormal_nociception_after4.78504014
3MP0001968_abnormal_touch/_nociception4.58626795
4MP0004858_abnormal_nervous_system4.45032424
5MP0001986_abnormal_taste_sensitivity4.19937520
6MP0002733_abnormal_thermal_nociception3.27484232
7MP0003656_abnormal_erythrocyte_physiolo3.22942766
8MP0001905_abnormal_dopamine_level3.20720553
9MP0004270_analgesia3.16141376
10MP0005083_abnormal_biliary_tract2.86047283
11MP0001529_abnormal_vocalization2.77068773
12MP0003787_abnormal_imprinting2.72415689
13MP0008875_abnormal_xenobiotic_pharmacok2.71489673
14MP0009379_abnormal_foot_pigmentation2.69376339
15MP0002734_abnormal_mechanical_nocicepti2.61251378
16MP0003693_abnormal_embryo_hatching2.57364916
17MP0006036_abnormal_mitochondrial_physio2.51684442
18MP0006276_abnormal_autonomic_nervous2.48360308
19MP0001970_abnormal_pain_threshold2.44731994
20MP0005423_abnormal_somatic_nervous2.41791364
21MP0005084_abnormal_gallbladder_morpholo2.29293072
22MP0006035_abnormal_mitochondrial_morpho2.22730473
23MP0004147_increased_porphyrin_level2.19678567
24MP0003300_gastrointestinal_ulcer2.18711481
25MP0005377_hearing/vestibular/ear_phenot2.17279820
26MP0003878_abnormal_ear_physiology2.17279820
27MP0010094_abnormal_chromosome_stability2.16525669
28MP0003183_abnormal_peptide_metabolism2.04076067
29MP0009697_abnormal_copulation2.02674997
30MP0006292_abnormal_olfactory_placode1.99173879
31MP0005645_abnormal_hypothalamus_physiol1.88265306
32MP0010030_abnormal_orbit_morphology1.82765200
33MP0003718_maternal_effect1.76214114
34MP0003646_muscle_fatigue1.76047071
35MP0003011_delayed_dark_adaptation1.73976818
36MP0003303_peritoneal_inflammation1.71330189
37MP0008058_abnormal_DNA_repair1.70990075
38MP0008007_abnormal_cellular_replicative1.66183030
39MP0003136_yellow_coat_color1.64139140
40MP0001270_distended_abdomen1.63281818
41MP0001348_abnormal_lacrimal_gland1.61396651
42MP0004742_abnormal_vestibular_system1.60012502
43MP0003315_abnormal_perineum_morphology1.59029145
44MP0003868_abnormal_feces_composition1.56903647
45MP0003436_decreased_susceptibility_to1.56188254
46MP0002254_reproductive_system_inflammat1.55796952
47MP0005171_absent_coat_pigmentation1.53379206
48MP0003283_abnormal_digestive_organ1.51546190
49MP0003121_genomic_imprinting1.47239930
50MP0002139_abnormal_hepatobiliary_system1.46864306
51MP0002837_dystrophic_cardiac_calcinosis1.45480043
52MP0008260_abnormal_autophagy1.44524433
53MP0000751_myopathy1.43742428
54MP0003329_amyloid_beta_deposits1.40977082
55MP0003111_abnormal_nucleus_morphology1.40792719
56MP0003045_fibrosis1.40046331
57MP0003866_abnormal_defecation1.39236618
58MP0002653_abnormal_ependyma_morphology1.38775658
59MP0004142_abnormal_muscle_tone1.38285240
60MP0002877_abnormal_melanocyte_morpholog1.38005310
61MP0002693_abnormal_pancreas_physiology1.37817214
62MP0005174_abnormal_tail_pigmentation1.35285983
63MP0002909_abnormal_adrenal_gland1.33571708
64MP0009780_abnormal_chondrocyte_physiolo1.33308099
65MP0003705_abnormal_hypodermis_morpholog1.31224358
66MP0002751_abnormal_autonomic_nervous1.31197854
67MP0010352_gastrointestinal_tract_polyps1.30794538
68MP0000604_amyloidosis1.29285883
69MP0002160_abnormal_reproductive_system1.28768915
70MP0008995_early_reproductive_senescence1.26494491
71MP0002822_catalepsy1.26492580
72MP0002277_abnormal_respiratory_mucosa1.24609811
73MP0009840_abnormal_foam_cell1.24472421
74MP0008872_abnormal_physiological_respon1.23822200
75MP0003172_abnormal_lysosome_physiology1.23576138
76MP0000749_muscle_degeneration1.14459767
77MP0003186_abnormal_redox_activity1.13579649
78MP0004510_myositis1.13418243
79MP0004947_skin_inflammation1.11854600
80MP0003077_abnormal_cell_cycle1.11040961
81MP0002638_abnormal_pupillary_reflex1.09072684
82MP0004133_heterotaxia1.07208303
83MP0001485_abnormal_pinna_reflex1.06799087
84MP0010307_abnormal_tumor_latency1.06139812
85MP0003122_maternal_imprinting1.06082242
86MP0004145_abnormal_muscle_electrophysio1.05535250
87MP0003191_abnormal_cellular_cholesterol1.04417168
88MP0005000_abnormal_immune_tolerance1.04368633
89MP0005085_abnormal_gallbladder_physiolo1.03189015
90MP0002396_abnormal_hematopoietic_system1.02995745
91MP0000015_abnormal_ear_pigmentation1.02639820
92MP0002928_abnormal_bile_duct1.01225958
93MP0001533_abnormal_skeleton_physiology1.00132759
94MP0005253_abnormal_eye_physiology0.99647982
95MP0001346_abnormal_lacrimal_gland0.99056928
96MP0001944_abnormal_pancreas_morphology0.98450880
97MP0000470_abnormal_stomach_morphology0.97321575
98MP0002210_abnormal_sex_determination0.97214097
99MP0002067_abnormal_sensory_capabilities0.96517525
100MP0008932_abnormal_embryonic_tissue0.96092269
101MP0001666_abnormal_nutrient_absorption0.95847002
102MP0004811_abnormal_neuron_physiology0.95321362
103MP0003137_abnormal_impulse_conducting0.94232220
104MP0000372_irregular_coat_pigmentation0.93070759
105MP0005394_taste/olfaction_phenotype0.92957400
106MP0005499_abnormal_olfactory_system0.92957400
107MP0009278_abnormal_bone_marrow0.91990520
108MP0010386_abnormal_urinary_bladder0.91064170
109MP0008961_abnormal_basal_metabolism0.90245106
110MP0004957_abnormal_blastocyst_morpholog0.90085136
111MP0002166_altered_tumor_susceptibility0.89999931
112MP0000358_abnormal_cell_content/0.89973404
113MP0003786_premature_aging0.89724485
114MP0005360_urolithiasis0.88778629
115MP0000013_abnormal_adipose_tissue0.88743256
116MP0003724_increased_susceptibility_to0.88724255
117MP0002019_abnormal_tumor_incidence0.86361405
118MP0001502_abnormal_circadian_rhythm0.86199292
119MP0005058_abnormal_lysosome_morphology0.86050854
120MP0005464_abnormal_platelet_physiology0.85001784
121MP0002722_abnormal_immune_system0.83563506
122MP0001800_abnormal_humoral_immune0.83193877
123MP0000049_abnormal_middle_ear0.82712155
124MP0003566_abnormal_cell_adhesion0.82373757
125MP0002933_joint_inflammation0.82213690
126MP0005310_abnormal_salivary_gland0.81715246
127MP0005220_abnormal_exocrine_pancreas0.81373546
128MP0010155_abnormal_intestine_physiology0.80932733
129MP0001835_abnormal_antigen_presentation0.80917487
130MP0002184_abnormal_innervation0.80698899
131MP0001299_abnormal_eye_distance/0.80377149
132MP0001845_abnormal_inflammatory_respons0.80320500
133MP0000689_abnormal_spleen_morphology0.80013445
134MP0008789_abnormal_olfactory_epithelium0.79943294
135MP0002078_abnormal_glucose_homeostasis0.79593801
136MP0001873_stomach_inflammation0.79532103
137MP0005451_abnormal_body_composition0.78762738
138MP0001188_hyperpigmentation0.78621900
139MP0002272_abnormal_nervous_system0.77246753
140MP0000750_abnormal_muscle_regeneration0.76373219
141MP0009745_abnormal_behavioral_response0.75802247
142MP0005387_immune_system_phenotype0.74872617
143MP0001790_abnormal_immune_system0.74872617
144MP0008877_abnormal_DNA_methylation0.74704445
145MP0001145_abnormal_male_reproductive0.74518831
146MP0008775_abnormal_heart_ventricle0.74310731
147MP0002398_abnormal_bone_marrow0.73761219
148MP0000609_abnormal_liver_physiology0.72959077
149MP0005076_abnormal_cell_differentiation0.71758948
150MP0001663_abnormal_digestive_system0.71046547
151MP0001929_abnormal_gametogenesis0.70972428
152MP0002723_abnormal_immune_serum0.70495897
153MP0005671_abnormal_response_to0.70098019
154MP0000026_abnormal_inner_ear0.69395589
155MP0009643_abnormal_urine_homeostasis0.69383136
156MP0000538_abnormal_urinary_bladder0.69097808
157MP0001849_ear_inflammation0.68733636
158MP0002249_abnormal_larynx_morphology0.67768694
159MP0000653_abnormal_sex_gland0.67562867
160MP0002557_abnormal_social/conspecific_i0.67356496
161MP0002419_abnormal_innate_immunity0.67275441
162MP0003698_abnormal_male_reproductive0.67178929
163MP0005535_abnormal_body_temperature0.67001643
164MP0002429_abnormal_blood_cell0.66397348
165MP0000685_abnormal_immune_system0.66384711
166MP0005448_abnormal_energy_balance0.64782173
167MP0000955_abnormal_spinal_cord0.63752878
168MP0003638_abnormal_response/metabolism_0.62870524
169MP0003879_abnormal_hair_cell0.62267361
170MP0008770_decreased_survivor_rate0.61596757
171MP0000313_abnormal_cell_death0.61571372
172MP0001765_abnormal_ion_homeostasis0.61427610
173MP0005025_abnormal_response_to0.61260564
174MP0002148_abnormal_hypersensitivity_rea0.60860182
175MP0009333_abnormal_splenocyte_physiolog0.60540047
176MP0000716_abnormal_immune_system0.60308515
177MP0000703_abnormal_thymus_morphology0.60142648
178MP0005397_hematopoietic_system_phenotyp0.59481416
179MP0001545_abnormal_hematopoietic_system0.59481416
180MP0003252_abnormal_bile_duct0.58901613
181MP0002229_neurodegeneration0.58775683
182MP0002118_abnormal_lipid_homeostasis0.58464896
183MP0006082_CNS_inflammation0.57086565
184MP0002006_tumorigenesis0.57069009
185MP0005166_decreased_susceptibility_to0.56404426
186MP0002452_abnormal_antigen_presenting0.56246513

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)6.10902214
2Acute necrotizing encephalopathy (HP:0006965)4.51083786
3Abnormal mitochondria in muscle tissue (HP:0008316)4.31730197
4Dysautonomia (HP:0002459)4.31377755
5Mitochondrial inheritance (HP:0001427)4.25099693
6Abnormal number of erythroid precursors (HP:0012131)4.23401290
7Hepatocellular necrosis (HP:0001404)4.14386489
8Testicular atrophy (HP:0000029)4.10865465
9Thoracolumbar scoliosis (HP:0002944)3.96483687
10Reticulocytopenia (HP:0001896)3.95350468
11Termporal pattern (HP:0011008)3.94355239
12Insidious onset (HP:0003587)3.94355239
13Segmental peripheral demyelination/remyelination (HP:0003481)3.87842737
14Action tremor (HP:0002345)3.77014070
15Abnormality of cells of the erythroid lineage (HP:0012130)3.70467723
16Increased CSF lactate (HP:0002490)3.68914707
17Impaired pain sensation (HP:0007328)3.63816386
18Abnormality of pain sensation (HP:0010832)3.63816386
19Mesangial abnormality (HP:0001966)3.62486466
20Acute encephalopathy (HP:0006846)3.60277449
21Hepatic necrosis (HP:0002605)3.51714009
22Hypercortisolism (HP:0001578)3.48190513
23Increased hepatocellular lipid droplets (HP:0006565)3.45630450
24Pheochromocytoma (HP:0002666)3.33726715
25Renal Fanconi syndrome (HP:0001994)3.29578665
26Progressive macrocephaly (HP:0004481)3.29274718
27Microvesicular hepatic steatosis (HP:0001414)3.27074963
28Aplasia/Hypoplasia of the sacrum (HP:0008517)3.19797353
29Reduced antithrombin III activity (HP:0001976)3.13787388
30Increased intramyocellular lipid droplets (HP:0012240)3.12580626
31Neuroendocrine neoplasm (HP:0100634)3.05530710
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98520121
33Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.96963676
34Lipid accumulation in hepatocytes (HP:0006561)2.94856101
35Distal arthrogryposis (HP:0005684)2.93691100
36Agammaglobulinemia (HP:0004432)2.91933160
37Recurrent gram-negative bacterial infections (HP:0005420)2.90789995
38Myokymia (HP:0002411)2.85656031
39Irregular epiphyses (HP:0010582)2.81421620
40Type I transferrin isoform profile (HP:0003642)2.80596524
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.78174485
42Abnormality of B cell number (HP:0010975)2.76364110
43Foot dorsiflexor weakness (HP:0009027)2.76230519
44Failure to thrive in infancy (HP:0001531)2.75994996
45B lymphocytopenia (HP:0010976)2.73200600
46Increased muscle lipid content (HP:0009058)2.72974915
47Hammertoe (HP:0001765)2.70009420
48Severe combined immunodeficiency (HP:0004430)2.69281076
49Attenuation of retinal blood vessels (HP:0007843)2.67943522
50Dicarboxylic aciduria (HP:0003215)2.66391334
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66391334
52Exertional dyspnea (HP:0002875)2.62874200
53Submucous cleft hard palate (HP:0000176)2.58496586
54Increased serum lactate (HP:0002151)2.57383866
55Hyporeflexia of lower limbs (HP:0002600)2.50248420
56Optic disc pallor (HP:0000543)2.49255386
57Abnormality of the foot musculature (HP:0001436)2.48268789
58Lumbar hyperlordosis (HP:0002938)2.47218651
59Cerebral palsy (HP:0100021)2.47190184
60Increased CSF protein (HP:0002922)2.45742728
61Poikilocytosis (HP:0004447)2.44760365
62Cerebral edema (HP:0002181)2.41164595
63Absent thumb (HP:0009777)2.41082135
64Supranuclear gaze palsy (HP:0000605)2.40453187
65Poikiloderma (HP:0001029)2.39183803
66Reticulocytosis (HP:0001923)2.36546644
67Patellar aplasia (HP:0006443)2.35091493
68Flat acetabular roof (HP:0003180)2.35078821
69Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.32897989
70Exercise intolerance (HP:0003546)2.30427730
71Hypothermia (HP:0002045)2.30334637
72Absent phalangeal crease (HP:0006109)2.28812771
73Ventricular fibrillation (HP:0001663)2.28551368
74Macrocytic anemia (HP:0001972)2.27988931
75Decreased motor nerve conduction velocity (HP:0003431)2.27663154
76Abnormal gallbladder morphology (HP:0012437)2.23118441
77Acanthocytosis (HP:0001927)2.22670279
78Oligomenorrhea (HP:0000876)2.22513101
79Arthropathy (HP:0003040)2.22162973
80Lactic acidosis (HP:0003128)2.22062322
81Aplasia/Hypoplasia of the patella (HP:0006498)2.21551284
82Increased IgM level (HP:0003496)2.21482831
83Cholelithiasis (HP:0001081)2.21011984
84Bundle branch block (HP:0011710)2.20481112
85Distal sensory impairment (HP:0002936)2.19210588
86Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19009629
87Pallor (HP:0000980)2.17727843
88Thyroid carcinoma (HP:0002890)2.17590188
89Acute lymphatic leukemia (HP:0006721)2.16943864
90Dyschromatopsia (HP:0007641)2.16769418
91Respiratory difficulties (HP:0002880)2.16534105
92Congenital stationary night blindness (HP:0007642)2.14587950
93Onion bulb formation (HP:0003383)2.12595660
94Steppage gait (HP:0003376)2.10682701
95Abnormality of the labia minora (HP:0012880)2.10671519
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10521210
97Hand muscle atrophy (HP:0009130)2.10100203
98Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08942436
99Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08942436
100Autoimmune hemolytic anemia (HP:0001890)2.08272178
101Areflexia of lower limbs (HP:0002522)2.08045084
102Maternal diabetes (HP:0009800)2.07965941
103Thoracic kyphosis (HP:0002942)2.07536443
104Abnormality of DNA repair (HP:0003254)2.07215699
105Bradycardia (HP:0001662)2.06816600
106Nasal speech (HP:0001611)2.06749243
107Eczematoid dermatitis (HP:0000976)2.06457271
108Rib fusion (HP:0000902)2.05964997
1093-Methylglutaconic aciduria (HP:0003535)2.05812429
110Abnormality of femoral epiphyses (HP:0006499)2.05637864
111Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.05637864
112Abnormality of the epiphysis of the femoral head (HP:0010574)2.04504171
11311 pairs of ribs (HP:0000878)2.03398344
114Autoimmune thrombocytopenia (HP:0001973)2.03307569
115Increased IgE level (HP:0003212)2.03306138
116Leukocytosis (HP:0001974)2.01725844
117Hypertensive crisis (HP:0100735)2.01666031
118Abnormal tarsal ossification (HP:0008369)2.01568732
119Colon cancer (HP:0003003)2.00154531
120Atonic seizures (HP:0010819)1.99834965
121Abnormal autonomic nervous system physiology (HP:0012332)1.99263189
122Mask-like facies (HP:0000298)1.98736348
123Broad distal phalanx of finger (HP:0009836)1.98706324
124Combined immunodeficiency (HP:0005387)1.97734162
125Aplastic anemia (HP:0001915)1.97265212
126Abnormal foot bone ossification (HP:0010675)1.96643086
127Sparse scalp hair (HP:0002209)1.96506818
128Protuberant abdomen (HP:0001538)1.96254641
129Pendular nystagmus (HP:0012043)1.96036099
130Flattened epiphyses (HP:0003071)1.95603449
131Meckel diverticulum (HP:0002245)1.95406344
132Abnormality of the ileum (HP:0001549)1.95267085
133Axonal loss (HP:0003447)1.95239897
134Interstitial pulmonary disease (HP:0006530)1.95060679
135Abnormality of calcium-phosphate metabolism (HP:0100530)1.94766110
136Bony spicule pigmentary retinopathy (HP:0007737)1.93882721
137Abnormality of the ischium (HP:0003174)1.93475258
138Molar tooth sign on MRI (HP:0002419)1.91649306
139Abnormality of midbrain morphology (HP:0002418)1.91649306
140Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89975953
141Myotonia (HP:0002486)1.89953606
142Distal lower limb muscle weakness (HP:0009053)1.89899150
143Cupped ribs (HP:0000887)1.89882355
144Global brain atrophy (HP:0002283)1.89672692
145Overlapping toe (HP:0001845)1.89459216
146Pancytopenia (HP:0001876)1.88386511
147Urinary glycosaminoglycan excretion (HP:0003541)1.87019303
148Mucopolysacchariduria (HP:0008155)1.87019303
149Muscle fiber atrophy (HP:0100295)1.86878579
150Abnormality of the intervertebral disk (HP:0005108)1.85575384
151Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85375815
152Abnormality of the parathyroid morphology (HP:0011766)1.85300007
153Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85284222
154Abnormality of the femoral head (HP:0003368)1.85170995
155Ragged-red muscle fibers (HP:0003200)1.84819304
156Generalized hyperpigmentation (HP:0007440)1.84414897
157Impaired proprioception (HP:0010831)1.83931618
158Impulsivity (HP:0100710)1.83706650
159Ovoid vertebral bodies (HP:0003300)1.83185331
160Multiple enchondromatosis (HP:0005701)1.81696599
161Hyperparathyroidism (HP:0000843)1.81529059
162Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80892211
163Abnormal protein N-linked glycosylation (HP:0012347)1.80892211
164Abnormal protein glycosylation (HP:0012346)1.80892211
165Abnormal glycosylation (HP:0012345)1.80892211
166Hyperbilirubinemia (HP:0002904)1.80857048
167Disproportionate short-trunk short stature (HP:0003521)1.80648482
168Autoamputation (HP:0001218)1.79664303
169Septo-optic dysplasia (HP:0100842)1.78692868
170Respiratory failure (HP:0002878)1.78486041
171Episodic fever (HP:0001954)1.78463399
172Hyperthyroidism (HP:0000836)1.78040771
173Increased neuronal autofluorescent lipopigment (HP:0002074)1.77186914
174Hyperglycinemia (HP:0002154)1.76909211
175Abnormality of the preputium (HP:0100587)1.76442488
176Aplasia/Hypoplasia of the thymus (HP:0010515)1.75899490
177Aplasia/Hypoplasia of the uvula (HP:0010293)1.75592884
178Panhypogammaglobulinemia (HP:0003139)1.74662314
179Abnormality of polysaccharide metabolism (HP:0011012)1.74304427
180Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74304427
181Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74304427
182Urinary urgency (HP:0000012)1.74122062
183Menstrual irregularities (HP:0000858)1.73736349
184Peripheral demyelination (HP:0011096)1.73165312
185Abnormality of the heme biosynthetic pathway (HP:0010472)1.73130995
186Absent radius (HP:0003974)1.72608484
187Abnormality of the vocal cords (HP:0008777)1.72211430
188Abnormality of the thoracic spine (HP:0100711)1.72115968
189Difficulty climbing stairs (HP:0003551)1.69478826
190Patent foramen ovale (HP:0001655)1.68141379
191Upper limb amyotrophy (HP:0009129)1.67855314
192Distal upper limb amyotrophy (HP:0007149)1.67855314
193Papilloma (HP:0012740)1.67655801
194Verrucae (HP:0200043)1.67655801
195Long toe (HP:0010511)1.66913751
196Late onset (HP:0003584)1.66519411
197Small epiphyses (HP:0010585)1.65372990
198Tetraparesis (HP:0002273)1.63692524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.30324792
2NME23.44169763
3NTRK13.15588607
4LMTK23.15575276
5BCKDK3.12409878
6MAP3K22.99749843
7RIPK42.95521282
8TESK22.77594765
9ERN12.71986306
10MAPKAPK32.48432434
11MAPK152.47078790
12EPHA32.43717835
13KDR2.36849124
14PBK2.27827382
15DYRK22.26858563
16KIT2.08778074
17MINK12.06356991
18MAP3K112.04620531
19KSR22.01631567
20MATK2.01170158
21MAP4K21.98866087
22SIK21.91393598
23RET1.87582016
24SCYL21.85844718
25VRK11.80318339
26STK161.77632644
27MAP4K11.74356721
28TRIB31.74231381
29INSRR1.70230699
30FRK1.68205858
31LIMK11.64419206
32NTRK31.64242620
33FGFR41.62883688
34FLT31.62677658
35FES1.59654590
36WNK31.55280194
37RPS6KA21.54278649
38MAP3K11.54139107
39JAK31.51808480
40CDC71.49657068
41FGFR31.49640330
42MAP2K21.49147298
43MAP3K91.47249553
44MARK31.46353137
45JAK11.46013897
46NUAK11.44987725
47MST1R1.44780605
48ARAF1.35759688
49ZAP701.28627218
50PKN21.27888721
51CAMKK21.23627676
52MAP2K11.23462632
53MAP2K41.22855893
54PNCK1.22336465
55SIK31.20018411
56EPHB11.18792077
57CSF1R1.16854031
58TAOK11.16475555
59TNK21.16064661
60CDC42BPA1.15621931
61MAP3K101.13925081
62ATR1.13328600
63TXK1.11753738
64WNK11.10300062
65GRK51.09458573
66PRKG21.08702248
67PLK41.08397147
68MAPK131.07530928
69TYK21.05568597
70SGK31.05344509
71PRKCH1.02725101
72TLK11.01394910
73MAP3K120.99551049
74TAF10.98388564
75DYRK30.97747608
76DYRK1B0.97366379
77JAK20.97099875
78MUSK0.96811108
79AURKA0.96552758
80SGK20.94493800
81EEF2K0.94160242
82MAP3K140.93545059
83MAP2K30.92654029
84PRKD30.91604391
85HIPK20.90162339
86TAOK20.87884118
87TBK10.86015305
88FER0.85309995
89STK40.85250016
90BLK0.84755115
91PDK20.84382506
92SYK0.84361393
93STK240.80674557
94PTK20.79430153
95CDK120.79407609
96RPS6KA50.78643626
97BMPR1B0.76525936
98CSNK1G30.75488128
99ADRBK10.75152859
100TIE10.74563160
101ABL20.74007988
102TRPM70.73712841
103RPS6KA40.73679398
104SGK4940.73588365
105SGK2230.73588365
106PDK10.73216797
107DAPK10.72542691
108TAOK30.71319179
109CHEK20.70925624
110PHKG10.70386503
111PHKG20.70386503
112TEC0.69665610
113RPS6KB20.68477295
114LRRK20.68366674
115CAMKK10.67595095
116ZAK0.67550537
117SMG10.66751996
118PDGFRA0.66355964
119MAP3K40.65096111
120PDPK10.64937427
121BMX0.63782607
122SIK10.63019933
123PRKD20.62000490
124PIM20.61850087
125OBSCN0.61754204
126SRPK10.60904779
127PTK60.60599724
128MAP3K50.59745453
129IKBKB0.59644723
130NEK90.59559181
131ICK0.58569250
132LATS20.56744652
133TESK10.56290093
134IRAK30.55362576
135PIK3CA0.52324133
136BUB10.51981129
137CDK70.51347499
138AURKB0.48140187
139MET0.47946354
140MAP3K30.47010484
141PLK10.46923561
142BTK0.46290579
143CSNK1G20.46199720
144PRKAA10.46107342
145RIPK10.46062992
146CDK90.45678411
147PDGFRB0.45650166
148TTN0.44337736
149MAPKAPK20.44185817
150PASK0.43390254
151ADRBK20.43290967
152CSNK1A1L0.43104860
153MAPK110.42228960
154MST40.41963851
155ITK0.41907865
156IRAK10.41648261
157PRKCI0.40626330
158LCK0.39931576
159CSNK1G10.39022139
160IRAK40.38648336
161MARK20.38536270
162CDK50.37831319
163UHMK10.37251003
164IKBKE0.37066210
165PRKCQ0.37036970
166CSK0.35671565
167WNK40.35412111
168LYN0.35279006
169RPS6KA60.34988620
170MAP3K70.34896008
171NME10.34689918
172GRK60.34350776
173CSNK2A20.33803512
174CSNK2A10.31241366
175PRKCD0.30603029
176RPS6KA10.30174537
177MAP2K70.29352140
178PKN10.29073624

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.05023283
2Ribosome_Homo sapiens_hsa030103.65189240
3Oxidative phosphorylation_Homo sapiens_hsa001903.60623097
4Parkinsons disease_Homo sapiens_hsa050123.49112464
5Base excision repair_Homo sapiens_hsa034103.44813579
6DNA replication_Homo sapiens_hsa030303.38300447
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.00055991
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.90080773
9Sulfur metabolism_Homo sapiens_hsa009202.82904274
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.56572062
11Proteasome_Homo sapiens_hsa030502.45741956
12Huntingtons disease_Homo sapiens_hsa050162.41280373
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.24391163
14Homologous recombination_Homo sapiens_hsa034402.22671196
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.22619880
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20891604
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.18463755
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.18371954
19Pyrimidine metabolism_Homo sapiens_hsa002402.15411013
20Carbohydrate digestion and absorption_Homo sapiens_hsa049732.13737139
21Alzheimers disease_Homo sapiens_hsa050102.11596550
22Primary immunodeficiency_Homo sapiens_hsa053402.06916261
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.96603318
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95802720
25Non-homologous end-joining_Homo sapiens_hsa034501.92607040
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.87253506
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85127040
28Type II diabetes mellitus_Homo sapiens_hsa049301.84149682
29Insulin secretion_Homo sapiens_hsa049111.83510551
30Fanconi anemia pathway_Homo sapiens_hsa034601.79079208
31Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.77091078
32Thyroid cancer_Homo sapiens_hsa052161.74322133
33Spliceosome_Homo sapiens_hsa030401.70640838
34Prolactin signaling pathway_Homo sapiens_hsa049171.62050621
35Caffeine metabolism_Homo sapiens_hsa002321.59582927
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.59254845
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55326750
38Dorso-ventral axis formation_Homo sapiens_hsa043201.46952645
39Purine metabolism_Homo sapiens_hsa002301.46711984
40Mismatch repair_Homo sapiens_hsa034301.42442350
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42036540
42Cardiac muscle contraction_Homo sapiens_hsa042601.41869549
43Insulin resistance_Homo sapiens_hsa049311.38324633
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38184097
45Synaptic vesicle cycle_Homo sapiens_hsa047211.36689989
46Insulin signaling pathway_Homo sapiens_hsa049101.29875760
47Glutathione metabolism_Homo sapiens_hsa004801.28648310
48Taste transduction_Homo sapiens_hsa047421.26093321
49Pancreatic secretion_Homo sapiens_hsa049721.25285230
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23955136
51Renin-angiotensin system_Homo sapiens_hsa046141.22694234
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20249663
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17611544
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16774580
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14903982
56ABC transporters_Homo sapiens_hsa020101.13356476
57Regulation of autophagy_Homo sapiens_hsa041401.12082580
58Leishmaniasis_Homo sapiens_hsa051401.10571439
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10312593
60One carbon pool by folate_Homo sapiens_hsa006701.10070745
61Central carbon metabolism in cancer_Homo sapiens_hsa052301.09508901
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08758569
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07995703
64mTOR signaling pathway_Homo sapiens_hsa041501.06122230
65Salmonella infection_Homo sapiens_hsa051321.01499964
66Fat digestion and absorption_Homo sapiens_hsa049751.00300468
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99537084
68Bile secretion_Homo sapiens_hsa049760.99428151
69Nucleotide excision repair_Homo sapiens_hsa034200.98120852
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98084626
71Glioma_Homo sapiens_hsa052140.95498912
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94182723
73Peroxisome_Homo sapiens_hsa041460.92745425
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.92710179
75B cell receptor signaling pathway_Homo sapiens_hsa046620.91264980
76Galactose metabolism_Homo sapiens_hsa000520.90764586
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.90122038
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89927849
79Metabolic pathways_Homo sapiens_hsa011000.88285715
80Linoleic acid metabolism_Homo sapiens_hsa005910.88022254
81Thyroid hormone synthesis_Homo sapiens_hsa049180.87856140
82Apoptosis_Homo sapiens_hsa042100.87068795
83Starch and sucrose metabolism_Homo sapiens_hsa005000.86138517
84Tuberculosis_Homo sapiens_hsa051520.85838816
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85333831
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84850797
87VEGF signaling pathway_Homo sapiens_hsa043700.84775617
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.84748716
89Viral myocarditis_Homo sapiens_hsa054160.84608101
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83290511
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83221959
92Phototransduction_Homo sapiens_hsa047440.83179275
93Hepatitis C_Homo sapiens_hsa051600.83167981
94Osteoclast differentiation_Homo sapiens_hsa043800.82533995
95Protein digestion and absorption_Homo sapiens_hsa049740.82375630
96Butanoate metabolism_Homo sapiens_hsa006500.81958892
97Folate biosynthesis_Homo sapiens_hsa007900.80669314
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80144317
99GnRH signaling pathway_Homo sapiens_hsa049120.80111969
100Toxoplasmosis_Homo sapiens_hsa051450.79880242
101Endometrial cancer_Homo sapiens_hsa052130.79833550
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79044608
103Asthma_Homo sapiens_hsa053100.78481365
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77589199
105Systemic lupus erythematosus_Homo sapiens_hsa053220.76081899
106Influenza A_Homo sapiens_hsa051640.74674337
107Sulfur relay system_Homo sapiens_hsa041220.74001068
108Mineral absorption_Homo sapiens_hsa049780.72921014
109Long-term potentiation_Homo sapiens_hsa047200.72369832
110Chronic myeloid leukemia_Homo sapiens_hsa052200.71963589
111Allograft rejection_Homo sapiens_hsa053300.71615587
112Vibrio cholerae infection_Homo sapiens_hsa051100.71531839
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71477092
114Pertussis_Homo sapiens_hsa051330.70971671
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70809112
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69940135
117TNF signaling pathway_Homo sapiens_hsa046680.69780168
118Estrogen signaling pathway_Homo sapiens_hsa049150.69457940
119Lysosome_Homo sapiens_hsa041420.68540010
120RNA transport_Homo sapiens_hsa030130.68380968
121Cholinergic synapse_Homo sapiens_hsa047250.67969829
122Phagosome_Homo sapiens_hsa041450.67575852
123Non-small cell lung cancer_Homo sapiens_hsa052230.67210461
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67081840
125Autoimmune thyroid disease_Homo sapiens_hsa053200.66317574
126Biosynthesis of amino acids_Homo sapiens_hsa012300.64929290
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64588392
128Dopaminergic synapse_Homo sapiens_hsa047280.64585230
129Glucagon signaling pathway_Homo sapiens_hsa049220.63143124
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61986780
131Acute myeloid leukemia_Homo sapiens_hsa052210.61963519
132Selenocompound metabolism_Homo sapiens_hsa004500.61696170
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61091586
134Fructose and mannose metabolism_Homo sapiens_hsa000510.60965479
135Pyruvate metabolism_Homo sapiens_hsa006200.59929425
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59397559
137N-Glycan biosynthesis_Homo sapiens_hsa005100.59254282
138Bladder cancer_Homo sapiens_hsa052190.59247977
139ErbB signaling pathway_Homo sapiens_hsa040120.58737295
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58622990
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58255176
142Endocytosis_Homo sapiens_hsa041440.57324272
143T cell receptor signaling pathway_Homo sapiens_hsa046600.55763086
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55473357
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.55095412
146Arachidonic acid metabolism_Homo sapiens_hsa005900.54216675
147Olfactory transduction_Homo sapiens_hsa047400.53527329
148FoxO signaling pathway_Homo sapiens_hsa040680.53521119
149Salivary secretion_Homo sapiens_hsa049700.53469217
150Hepatitis B_Homo sapiens_hsa051610.53177863
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52841923
152Graft-versus-host disease_Homo sapiens_hsa053320.52657532
153Carbon metabolism_Homo sapiens_hsa012000.52146714
154Hematopoietic cell lineage_Homo sapiens_hsa046400.52128536
155Nicotine addiction_Homo sapiens_hsa050330.52071858
156Cysteine and methionine metabolism_Homo sapiens_hsa002700.51767666
157Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51589046
158AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50882854
159Collecting duct acid secretion_Homo sapiens_hsa049660.50878721
160Cyanoamino acid metabolism_Homo sapiens_hsa004600.49569101
161Tryptophan metabolism_Homo sapiens_hsa003800.49303311
162Prion diseases_Homo sapiens_hsa050200.48243162
163Legionellosis_Homo sapiens_hsa051340.47487962
164Chemokine signaling pathway_Homo sapiens_hsa040620.47486809
165RNA degradation_Homo sapiens_hsa030180.47084293
166Amoebiasis_Homo sapiens_hsa051460.46630147
167Type I diabetes mellitus_Homo sapiens_hsa049400.46320520
168Alcoholism_Homo sapiens_hsa050340.46089936
169Ether lipid metabolism_Homo sapiens_hsa005650.44951264
170Protein export_Homo sapiens_hsa030600.42843348
171Cell cycle_Homo sapiens_hsa041100.42569513
172NF-kappa B signaling pathway_Homo sapiens_hsa040640.42275964
173Rheumatoid arthritis_Homo sapiens_hsa053230.37196426
174Epstein-Barr virus infection_Homo sapiens_hsa051690.36579254
175Chemical carcinogenesis_Homo sapiens_hsa052040.35998196
176Staphylococcus aureus infection_Homo sapiens_hsa051500.33365661
177Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33025443
178Steroid hormone biosynthesis_Homo sapiens_hsa001400.31229841
179Antigen processing and presentation_Homo sapiens_hsa046120.30395418
180Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28398019
181Steroid biosynthesis_Homo sapiens_hsa001000.27959617
182Drug metabolism - other enzymes_Homo sapiens_hsa009830.27859323
183Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25411953
184Basal cell carcinoma_Homo sapiens_hsa052170.24966941
185Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18787885
186Basal transcription factors_Homo sapiens_hsa030220.14827391

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