AMMECR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The exact function of this gene is not known, however, submicroscopic deletion of the X chromosome including this gene, COL4A5, and FACL4 genes, result in a contiguous gene deletion syndrome, the AMME complex (Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)4.31166176
2establishment of integrated proviral latency (GO:0075713)4.07319984
3regulation of centriole replication (GO:0046599)3.85004038
4histone exchange (GO:0043486)3.83473617
5purine nucleobase biosynthetic process (GO:0009113)3.82755050
6DNA replication-dependent nucleosome assembly (GO:0006335)3.75338851
7DNA replication-dependent nucleosome organization (GO:0034723)3.75338851
8regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.72698104
9protoporphyrinogen IX biosynthetic process (GO:0006782)3.64372192
10IMP biosynthetic process (GO:0006188)3.63117053
11negative regulation of chromosome segregation (GO:0051985)3.59947581
12negative regulation of mitotic sister chromatid separation (GO:2000816)3.56489404
13negative regulation of sister chromatid segregation (GO:0033046)3.56489404
14negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.56489404
15negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.56489404
16negative regulation of mitotic sister chromatid segregation (GO:0033048)3.56489404
17spindle checkpoint (GO:0031577)3.53443974
18nucleobase biosynthetic process (GO:0046112)3.53276825
19ribosome assembly (GO:0042255)3.49717500
20establishment of chromosome localization (GO:0051303)3.48692675
21regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.46313281
22regulation of mitotic metaphase/anaphase transition (GO:0030071)3.46313281
23mitotic spindle checkpoint (GO:0071174)3.45865265
24nuclear pore organization (GO:0006999)3.40537736
25regulation of chromosome segregation (GO:0051983)3.39418284
26nuclear pore complex assembly (GO:0051292)3.36388422
27double-strand break repair via nonhomologous end joining (GO:0006303)3.35866928
28non-recombinational repair (GO:0000726)3.35866928
29mitotic spindle assembly checkpoint (GO:0007094)3.35764930
30spindle assembly checkpoint (GO:0071173)3.34382602
31DNA ligation (GO:0006266)3.33668163
32regulation of mitotic sister chromatid separation (GO:0010965)3.32258652
33regulation of mitotic sister chromatid segregation (GO:0033047)3.32258652
34regulation of sister chromatid segregation (GO:0033045)3.32258652
35porphyrin-containing compound biosynthetic process (GO:0006779)3.30618987
36somatic hypermutation of immunoglobulin genes (GO:0016446)3.30297719
37somatic diversification of immune receptors via somatic mutation (GO:0002566)3.30297719
38folic acid-containing compound biosynthetic process (GO:0009396)3.28358276
39pre-miRNA processing (GO:0031054)3.23196626
40chromatin assembly or disassembly (GO:0006333)3.22968319
41ATP-dependent chromatin remodeling (GO:0043044)3.22426368
42protein complex localization (GO:0031503)3.21781526
43kinetochore organization (GO:0051383)3.18103038
44chromosome segregation (GO:0007059)3.16928648
45ribosomal small subunit assembly (GO:0000028)3.15397116
46proteasome assembly (GO:0043248)3.12999132
47IMP metabolic process (GO:0046040)3.12401823
48regulation of centrosome cycle (GO:0046605)3.11555608
49regulation of translational fidelity (GO:0006450)3.11197836
50desmosome organization (GO:0002934)3.05612666
51cellular protein complex localization (GO:0034629)3.03980739
52tetrapyrrole biosynthetic process (GO:0033014)2.97946911
53erythrocyte maturation (GO:0043249)2.96092183
54meiotic chromosome segregation (GO:0045132)2.94482958
55DNA strand renaturation (GO:0000733)2.92806762
56nuclear envelope organization (GO:0006998)2.91936971
57RNA-dependent DNA replication (GO:0006278)2.90102608
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.90000521
59DNA conformation change (GO:0071103)2.89998772
60regulation of centrosome duplication (GO:0010824)2.87066041
61establishment of viral latency (GO:0019043)2.85461134
62DNA unwinding involved in DNA replication (GO:0006268)2.79820219
63mitotic sister chromatid cohesion (GO:0007064)2.77173373
64protein localization to kinetochore (GO:0034501)2.77018499
65viral transcription (GO:0019083)2.73547415
66translational termination (GO:0006415)2.68157178
67kinetochore assembly (GO:0051382)2.61812900
68telomere maintenance via semi-conservative replication (GO:0032201)2.61387145
69maturation of SSU-rRNA (GO:0030490)2.57688081
70telomere maintenance via recombination (GO:0000722)2.56205540
71mitotic recombination (GO:0006312)2.55506785
72pore complex assembly (GO:0046931)2.54699105
73replication fork processing (GO:0031297)2.52556377
74definitive hemopoiesis (GO:0060216)2.52216937
75mitotic nuclear envelope disassembly (GO:0007077)2.51765464
76mitotic G2/M transition checkpoint (GO:0044818)2.48463548
77ribosomal small subunit biogenesis (GO:0042274)2.46600566
783-UTR-mediated mRNA stabilization (GO:0070935)2.44705539
79protein localization to chromosome, centromeric region (GO:0071459)2.44490146
80DNA replication checkpoint (GO:0000076)2.42135093
81DNA strand elongation involved in DNA replication (GO:0006271)2.38622698
82CENP-A containing nucleosome assembly (GO:0034080)2.36571265
83maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.35304333
84ribosomal large subunit biogenesis (GO:0042273)2.35197209
85chromatin remodeling at centromere (GO:0031055)2.34635892
86DNA replication initiation (GO:0006270)2.34500913
87hippo signaling (GO:0035329)2.34019425
88negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.33764315
89regulation of double-strand break repair (GO:2000779)2.33276286
90embryonic process involved in female pregnancy (GO:0060136)2.32720167
91mitotic chromosome condensation (GO:0007076)2.31532518
92nuclear envelope disassembly (GO:0051081)2.30760472
93membrane disassembly (GO:0030397)2.30760472
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.29605408
95formation of translation preinitiation complex (GO:0001731)2.29517482
96bone trabecula formation (GO:0060346)2.29443158
97DNA topological change (GO:0006265)2.29040158
98regulation of DNA endoreduplication (GO:0032875)2.27576380
99wound healing, spreading of epidermal cells (GO:0035313)2.26968650
100DNA strand elongation (GO:0022616)2.26032777
101regulation of nuclear cell cycle DNA replication (GO:0033262)2.25491534
102nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.25214805
103positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.24398093
104positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.24398093
105positive regulation of mitotic sister chromatid separation (GO:1901970)2.24398093
106cellular response to ionizing radiation (GO:0071479)2.23079175
107negative regulation of DNA repair (GO:0045738)2.22947216
108sister chromatid segregation (GO:0000819)2.22774136
109SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.21359900
110positive regulation of DNA-dependent DNA replication (GO:2000105)2.19985037
111mitotic metaphase plate congression (GO:0007080)2.19970456
112mitotic G2 DNA damage checkpoint (GO:0007095)2.19305959
113regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.18353025
114translational elongation (GO:0006414)2.16480234
115translational initiation (GO:0006413)2.16174785
116paraxial mesoderm development (GO:0048339)2.14931687
117keratinocyte proliferation (GO:0043616)2.14458145
118DNA replication-independent nucleosome organization (GO:0034724)2.14017898
119DNA replication-independent nucleosome assembly (GO:0006336)2.14017898
120regulation of histone H3-K9 methylation (GO:0051570)2.13677670
121regulation of helicase activity (GO:0051095)2.13469655
122neural crest cell development (GO:0014032)2.13353249
123protein targeting to ER (GO:0045047)2.13152397
124cotranslational protein targeting to membrane (GO:0006613)2.11274553
125viral life cycle (GO:0019058)2.10933676
126positive regulation of chromosome segregation (GO:0051984)2.10803539
127DNA duplex unwinding (GO:0032508)2.09670070
128attachment of spindle microtubules to kinetochore (GO:0008608)2.09408707
129germ cell migration (GO:0008354)2.08662291
130mitotic sister chromatid segregation (GO:0000070)2.08166288
131response to X-ray (GO:0010165)2.07871483
132dosage compensation (GO:0007549)2.07745046
133regulation of double-strand break repair via homologous recombination (GO:0010569)2.07613295
134telomere maintenance via telomere lengthening (GO:0010833)2.07549897
135negative regulation by host of viral transcription (GO:0043922)2.07545433
136DNA geometric change (GO:0032392)2.07283611
137regulation of RIG-I signaling pathway (GO:0039535)2.06427223
138telomere maintenance (GO:0000723)2.05127592
139regulation of interleukin-8 secretion (GO:2000482)2.04951678
140metaphase plate congression (GO:0051310)2.04778117
141establishment of protein localization to endoplasmic reticulum (GO:0072599)2.03275815
142heterochromatin organization (GO:0070828)2.02499366
143negative regulation of DNA-dependent DNA replication (GO:2000104)2.01015176
144antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.00898489
145telomere organization (GO:0032200)2.00615996
146cellular protein complex disassembly (GO:0043624)2.00328719
147mRNA stabilization (GO:0048255)1.99933742
148RNA stabilization (GO:0043489)1.99933742
149activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO1.99860443
150positive regulation of interleukin-8 secretion (GO:2000484)1.98968572
151nucleotide-excision repair, DNA gap filling (GO:0006297)1.97851421
152mesodermal cell differentiation (GO:0048333)1.96756894
153regulation of mitotic spindle checkpoint (GO:1903504)1.95775229
154regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)1.95775229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.59312767
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.89517619
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.97465027
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.68683000
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.32605878
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.21897234
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00162605
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.86163864
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.74769275
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.70505571
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46380078
12GATA1_22025678_ChIP-Seq_K562_Human2.30685904
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16438154
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.13929805
15ELK1_19687146_ChIP-ChIP_HELA_Human2.08894564
16AR_21909140_ChIP-Seq_LNCAP_Human2.03755349
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.03057435
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95238519
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.92128498
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.84946777
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84553384
22MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82641196
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79430509
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78990969
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78283019
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77898747
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71531007
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68965346
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68632363
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.64554491
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60725568
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.60204158
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59107200
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58482487
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.49681993
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.48150437
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46847441
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46847441
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45664736
40NANOG_16153702_ChIP-ChIP_HESCs_Human1.45451163
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44953260
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43549311
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41679177
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41352909
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37902857
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36180399
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35139304
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34950105
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34507568
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32441623
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31954196
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31691362
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30805783
54VDR_23849224_ChIP-Seq_CD4+_Human1.29437780
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28947805
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.27275242
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27183565
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27017103
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26888487
60XRN2_22483619_ChIP-Seq_HELA_Human1.26082223
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25869978
62GABP_19822575_ChIP-Seq_HepG2_Human1.24945345
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23824091
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22147663
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20929209
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20670229
67MYB_26560356_Chip-Seq_TH2_Human1.17339873
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16805239
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16285791
70KDM5A_27292631_Chip-Seq_BREAST_Human1.16249548
71SPI1_23547873_ChIP-Seq_NB4_Human1.15521943
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.15494635
73MYC_22102868_ChIP-Seq_BL_Human1.15431457
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.15245470
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14766812
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.14638518
77EWS_26573619_Chip-Seq_HEK293_Human1.13877897
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13671762
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13671762
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13671762
81TTF2_22483619_ChIP-Seq_HELA_Human1.13118426
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13034114
83DCP1A_22483619_ChIP-Seq_HELA_Human1.12584326
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12125533
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10885812
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09490838
87MYC_18940864_ChIP-ChIP_HL60_Human1.08956286
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07654495
89* SOX17_20123909_ChIP-Seq_XEN_Mouse1.07520465
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07204895
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07093954
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06361894
93FOXP3_21729870_ChIP-Seq_TREG_Human1.06151733
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.04584409
95* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03732237
96MYB_26560356_Chip-Seq_TH1_Human1.03373069
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01610570
98BRD4_25478319_ChIP-Seq_HGPS_Human1.01482851
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01407988
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01273031
101TFEB_21752829_ChIP-Seq_HELA_Human1.00272281
102FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98668586
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96660593
104NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95580507
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94987452
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92626369
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91330532
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91304798
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88669797
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88442719
111WT1_19549856_ChIP-ChIP_CCG9911_Human0.88312560
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87876656
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87613457
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87411121
115ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87238978
116UBF1/2_26484160_Chip-Seq_HMECs_Human0.87203638
117NANOG_21062744_ChIP-ChIP_HESCs_Human0.87192972
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86774715
119PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86570398
120ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86407016
121E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86048882
122FUS_26573619_Chip-Seq_HEK293_Human0.86030578
123SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85732959
124SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84422874
125YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84280130
126SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83681377
127NANOG_18555785_ChIP-Seq_MESCs_Mouse0.83271983
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83265582
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82954460
130IRF8_27001747_Chip-Seq_BMDM_Mouse0.82427026
131BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81759167
132VDR_21846776_ChIP-Seq_THP-1_Human0.81230777
133ELK1_22589737_ChIP-Seq_MCF10A_Human0.80828538
134CHD1_26751641_Chip-Seq_LNCaP_Human0.80658441
135CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79898102
136CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79772190
137MAF_26560356_Chip-Seq_TH1_Human0.79217424
138GATA4_21415370_ChIP-Seq_HL-1_Mouse0.78957946
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77863872
140SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.75284796
141NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73705922
142HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72727513
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.71984316
144CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71321158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.25340147
2MP0003890_abnormal_embryonic-extraembry2.83551935
3MP0003941_abnormal_skin_development2.65506526
4MP0009697_abnormal_copulation2.60149516
5MP0003656_abnormal_erythrocyte_physiolo2.52072116
6MP0005275_abnormal_skin_tensile2.48772601
7MP0008057_abnormal_DNA_replication2.28844130
8MP0008438_abnormal_cutaneous_collagen2.12524016
9MP0006054_spinal_hemorrhage2.06930919
10MP0001730_embryonic_growth_arrest2.04593551
11MP0002009_preneoplasia2.04234248
12MP0010094_abnormal_chromosome_stability2.02954810
13MP0010352_gastrointestinal_tract_polyps1.89542348
14MP0003718_maternal_effect1.84489573
15MP0003705_abnormal_hypodermis_morpholog1.77415867
16MP0003077_abnormal_cell_cycle1.71160100
17MP0005503_abnormal_tendon_morphology1.69020197
18MP0010030_abnormal_orbit_morphology1.67206981
19MP0004957_abnormal_blastocyst_morpholog1.66374548
20MP0003111_abnormal_nucleus_morphology1.64002557
21MP0002084_abnormal_developmental_patter1.56566274
22MP0002098_abnormal_vibrissa_morphology1.55820009
23MP0009053_abnormal_anal_canal1.55424976
24MP0003693_abnormal_embryo_hatching1.55367737
25MP0002080_prenatal_lethality1.54426059
26MP0008007_abnormal_cellular_replicative1.53120200
27MP0005083_abnormal_biliary_tract1.52012430
28MP0003279_aneurysm1.47966883
29MP0003566_abnormal_cell_adhesion1.46250435
30MP0002085_abnormal_embryonic_tissue1.45936138
31MP0009672_abnormal_birth_weight1.43919432
32MP0003567_abnormal_fetal_cardiomyocyte1.43698752
33MP0002396_abnormal_hematopoietic_system1.41703528
34MP0005076_abnormal_cell_differentiation1.41453027
35MP0002877_abnormal_melanocyte_morpholog1.41320705
36MP0004808_abnormal_hematopoietic_stem1.39342665
37MP0002060_abnormal_skin_morphology1.38652874
38MP0010234_abnormal_vibrissa_follicle1.38622106
39MP0002796_impaired_skin_barrier1.38055434
40MP0000490_abnormal_crypts_of1.33882633
41MP0000383_abnormal_hair_follicle1.32932371
42MP0005501_abnormal_skin_physiology1.29499191
43MP0002006_tumorigenesis1.27737900
44MP0001346_abnormal_lacrimal_gland1.27010067
45MP0004264_abnormal_extraembryonic_tissu1.24864519
46MP0002166_altered_tumor_susceptibility1.23054101
47MP0003453_abnormal_keratinocyte_physiol1.22611642
48MP0002938_white_spotting1.22595776
49MP0003123_paternal_imprinting1.22267335
50MP0008932_abnormal_embryonic_tissue1.21302753
51MP0000350_abnormal_cell_proliferation1.21123581
52MP0005623_abnormal_meninges_morphology1.19743612
53MP0001243_abnormal_dermal_layer1.19436658
54MP0010307_abnormal_tumor_latency1.18653359
55MP0000313_abnormal_cell_death1.17656743
56MP0000579_abnormal_nail_morphology1.16486981
57MP0001545_abnormal_hematopoietic_system1.16012786
58MP0005397_hematopoietic_system_phenotyp1.16012786
59MP0009703_decreased_birth_body1.14745920
60MP0008058_abnormal_DNA_repair1.13450484
61MP0001216_abnormal_epidermal_layer1.11533676
62MP0005023_abnormal_wound_healing1.10884632
63MP0000516_abnormal_urinary_system1.10039096
64MP0005367_renal/urinary_system_phenotyp1.10039096
65MP0002132_abnormal_respiratory_system1.10010521
66MP0004272_abnormal_basement_membrane1.08800584
67MP0001293_anophthalmia1.05823770
68MP0008877_abnormal_DNA_methylation1.05406399
69MP0009250_abnormal_appendicular_skeleto1.04284018
70MP0005508_abnormal_skeleton_morphology1.03400001
71MP0002148_abnormal_hypersensitivity_rea1.03091051
72MP0000377_abnormal_hair_follicle1.02746268
73MP0001835_abnormal_antigen_presentation1.02615183
74MP0004197_abnormal_fetal_growth/weight/1.02331014
75MP0000647_abnormal_sebaceous_gland1.01708742
76MP0003950_abnormal_plasma_membrane1.01233015
77MP0000858_altered_metastatic_potential0.99839695
78MP0000733_abnormal_muscle_development0.99821075
79MP0008995_early_reproductive_senescence0.99011424
80MP0001286_abnormal_eye_development0.98310954
81MP0003755_abnormal_palate_morphology0.97274454
82MP0002163_abnormal_gland_morphology0.96642970
83MP0003984_embryonic_growth_retardation0.95730428
84MP0002088_abnormal_embryonic_growth/wei0.95418518
85MP0001672_abnormal_embryogenesis/_devel0.95020592
86MP0005380_embryogenesis_phenotype0.95020592
87MP0003385_abnormal_body_wall0.94978541
88MP0000432_abnormal_head_morphology0.94954418
89MP0004381_abnormal_hair_follicle0.94499963
90MP0000427_abnormal_hair_cycle0.94312669
91MP0000767_abnormal_smooth_muscle0.93910903
92MP0003186_abnormal_redox_activity0.93803563
93MP0001915_intracranial_hemorrhage0.93595677
94MP0004947_skin_inflammation0.93388921
95MP0009278_abnormal_bone_marrow0.93336617
96MP0000537_abnormal_urethra_morphology0.92394220
97MP0003448_altered_tumor_morphology0.91912991
98MP0002111_abnormal_tail_morphology0.91830290
99MP0002254_reproductive_system_inflammat0.91609682
100MP0000428_abnormal_craniofacial_morphol0.91399741
101MP0005075_abnormal_melanosome_morpholog0.91203452
102MP0004185_abnormal_adipocyte_glucose0.90939772
103MP0003786_premature_aging0.90432101
104MP0000762_abnormal_tongue_morphology0.90288173
105MP0003121_genomic_imprinting0.90135024
106MP0003763_abnormal_thymus_physiology0.89436189
107MP0000358_abnormal_cell_content/0.89163989
108MP0000566_synostosis0.88874356
109MP0002282_abnormal_trachea_morphology0.88657997
110MP0001661_extended_life_span0.88630517
111MP0001188_hyperpigmentation0.87193069
112MP0002086_abnormal_extraembryonic_tissu0.86932535
113MP0003828_pulmonary_edema0.86922599
114MP0006035_abnormal_mitochondrial_morpho0.86626821
115MP0009333_abnormal_splenocyte_physiolog0.86144722
116MP0010678_abnormal_skin_adnexa0.85881071
117MP0005451_abnormal_body_composition0.83837184
118MP0005621_abnormal_cell_physiology0.83658730
119MP0002019_abnormal_tumor_incidence0.83604172
120MP0004233_abnormal_muscle_weight0.83300816
121MP0005384_cellular_phenotype0.81641514
122MP0003937_abnormal_limbs/digits/tail_de0.81536114
123MP0003221_abnormal_cardiomyocyte_apopto0.81274826
124MP0001697_abnormal_embryo_size0.80886826
125MP0010771_integument_phenotype0.80384047
126MP0000049_abnormal_middle_ear0.80061431
127MP0009931_abnormal_skin_appearance0.79892756
128MP0003436_decreased_susceptibility_to0.79702946
129MP0009785_altered_susceptibility_to0.79279437
130MP0003942_abnormal_urinary_system0.79230978
131MP0000627_abnormal_mammary_gland0.78929610
132MP0002210_abnormal_sex_determination0.78665648
133MP0005408_hypopigmentation0.78304780
134MP0002697_abnormal_eye_size0.77554588
135MP0002177_abnormal_outer_ear0.77188883
136MP0001881_abnormal_mammary_gland0.76678813
137MP0001191_abnormal_skin_condition0.75083722
138MP0003119_abnormal_digestive_system0.71542715
139MP0000372_irregular_coat_pigmentation0.69784550
140MP0001529_abnormal_vocalization0.69701089
141MP0001145_abnormal_male_reproductive0.69539849
142MP0001929_abnormal_gametogenesis0.68558430
143MP0003943_abnormal_hepatobiliary_system0.65213001
144MP0001119_abnormal_female_reproductive0.64907713
145MP0003935_abnormal_craniofacial_develop0.64241734

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)3.51632180
2Birth length less than 3rd percentile (HP:0003561)3.27480069
3Aplasia/Hypoplasia of the uvula (HP:0010293)3.03810577
4Syringomyelia (HP:0003396)3.01333023
5Spinal cord lesions (HP:0100561)3.01333023
6Duodenal stenosis (HP:0100867)2.89636433
7Small intestinal stenosis (HP:0012848)2.89636433
8Abnormal lung lobation (HP:0002101)2.83950726
9Lip pit (HP:0100267)2.81411104
10Reticulocytosis (HP:0001923)2.75019260
11Abnormality of the parietal bone (HP:0002696)2.72899246
12Short 4th metacarpal (HP:0010044)2.66753018
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66753018
14Acanthocytosis (HP:0001927)2.63281090
15Volvulus (HP:0002580)2.62689035
16Reticulocytopenia (HP:0001896)2.59750224
17Protrusio acetabuli (HP:0003179)2.56502420
18Short middle phalanx of the 5th finger (HP:0004220)2.56017710
19Selective tooth agenesis (HP:0001592)2.53952589
20Rhabdomyosarcoma (HP:0002859)2.52300390
21Abnormality of the nasal septum (HP:0000419)2.48267218
22Abnormality of the fetal cardiovascular system (HP:0010948)2.46056411
23Abnormal umbilical cord blood vessels (HP:0011403)2.46056411
24Single umbilical artery (HP:0001195)2.46056411
25Medulloblastoma (HP:0002885)2.43284544
26Abnormality of the duodenum (HP:0002246)2.41613534
27Ependymoma (HP:0002888)2.40535135
28Woolly hair (HP:0002224)2.39582757
29Increased nuchal translucency (HP:0010880)2.36181912
30Aplasia cutis congenita (HP:0001057)2.31537257
31Absent radius (HP:0003974)2.29537601
32Chromsome breakage (HP:0040012)2.29429795
33Abnormality of reticulocytes (HP:0004312)2.27283212
34Neoplasm of the small intestine (HP:0100833)2.26799152
35Biliary tract neoplasm (HP:0100574)2.24480362
36Curly hair (HP:0002212)2.24203110
37Hypoplastic pelvis (HP:0008839)2.22145074
38Premature rupture of membranes (HP:0001788)2.20700508
39Natal tooth (HP:0000695)2.18229242
40Abnormality of the umbilical cord (HP:0010881)2.18188088
41Cortical dysplasia (HP:0002539)2.18117650
42Abnormal number of incisors (HP:0011064)2.17271681
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17105707
44Deep philtrum (HP:0002002)2.15751710
45Cholecystitis (HP:0001082)2.09188114
46Abnormal gallbladder physiology (HP:0012438)2.09188114
47Absent forearm bone (HP:0003953)2.09089642
48Aplasia involving forearm bones (HP:0009822)2.09089642
49Neoplasm of the colon (HP:0100273)2.08159983
50Ectopic kidney (HP:0000086)2.06424420
51Cafe-au-lait spot (HP:0000957)2.06257630
52Abnormality of the carotid arteries (HP:0005344)2.05779219
53Glioma (HP:0009733)2.05605724
54Osteolytic defects of the hand bones (HP:0009699)2.04414289
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.04414289
56Abnormal number of erythroid precursors (HP:0012131)2.04404422
57Onycholysis (HP:0001806)2.03001301
58Hypoplastic labia majora (HP:0000059)2.02452918
59Oral leukoplakia (HP:0002745)2.00074934
60Uterine neoplasm (HP:0010784)1.99849728
61Abnormality of nail color (HP:0100643)1.98956278
62Midline defect of the nose (HP:0004122)1.97766592
63Abnormality of cells of the erythroid lineage (HP:0012130)1.97610403
64Neoplasm of the rectum (HP:0100743)1.96851947
65Abnormality of methionine metabolism (HP:0010901)1.96336046
66Abnormality of the astrocytes (HP:0100707)1.92941690
67Astrocytoma (HP:0009592)1.92941690
68Abnormality of homocysteine metabolism (HP:0010919)1.92262658
69Homocystinuria (HP:0002156)1.92262658
70Abnormality of the labia minora (HP:0012880)1.91783538
71Mesomelia (HP:0003027)1.91717865
72Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91599388
73Choanal atresia (HP:0000453)1.90923608
74Sparse scalp hair (HP:0002209)1.90755206
75Supernumerary ribs (HP:0005815)1.90702158
76Hyperbilirubinemia (HP:0002904)1.88291128
77Hypotrichosis (HP:0001006)1.87442293
78Angiofibromas (HP:0010615)1.87200559
79Adenoma sebaceum (HP:0009720)1.87200559
80Clubbing of toes (HP:0100760)1.87040802
81Absent frontal sinuses (HP:0002688)1.86838557
82Supernumerary bones of the axial skeleton (HP:0009144)1.85434672
83Cholelithiasis (HP:0001081)1.85318284
84Fragile skin (HP:0001030)1.85126053
85Deviation of the thumb (HP:0009603)1.84989008
86Sloping forehead (HP:0000340)1.84703104
87Gastrointestinal carcinoma (HP:0002672)1.84637756
88Malignant gastrointestinal tract tumors (HP:0006749)1.84637756
89Abnormal gallbladder morphology (HP:0012437)1.84439583
90Abnormalities of placenta or umbilical cord (HP:0001194)1.83077282
91Abnormality of the distal phalanx of the thumb (HP:0009617)1.82649027
92Mediastinal lymphadenopathy (HP:0100721)1.82406859
93Rectal prolapse (HP:0002035)1.82081902
94Breast carcinoma (HP:0003002)1.81685498
95Right ventricular cardiomyopathy (HP:0011663)1.81347480
96Acute myeloid leukemia (HP:0004808)1.80887644
97Abnormality of the labia majora (HP:0012881)1.79805086
98Ovarian neoplasm (HP:0100615)1.79598595
99White forelock (HP:0002211)1.77460741
100Long eyelashes (HP:0000527)1.77010794
101Autoamputation (HP:0001218)1.76958889
102Septate vagina (HP:0001153)1.75960400
10311 pairs of ribs (HP:0000878)1.75713841
104Embryonal neoplasm (HP:0002898)1.75542998
105Pili torti (HP:0003777)1.74831530
106Breast hypoplasia (HP:0003187)1.74598529
107Atrophic scars (HP:0001075)1.74349082
108Abnormality of chromosome stability (HP:0003220)1.74313222
109Multiple enchondromatosis (HP:0005701)1.74107497
110Breech presentation (HP:0001623)1.73940712
111Neoplasm of the pancreas (HP:0002894)1.73855593
112Abnormality of the 4th metacarpal (HP:0010012)1.73232929
113Rib fusion (HP:0000902)1.72832734
114Papillary thyroid carcinoma (HP:0002895)1.72262824
115Congenital, generalized hypertrichosis (HP:0004540)1.72032366
116Abnormality of the incisor (HP:0000676)1.71859564
117Paralysis (HP:0003470)1.71775172
118Overlapping toe (HP:0001845)1.71398250
119Osteomalacia (HP:0002749)1.70855434
120Cystic hygroma (HP:0000476)1.69440678
121Ankyloglossia (HP:0010296)1.69145466
122High anterior hairline (HP:0009890)1.68859990
123Abnormality of the heme biosynthetic pathway (HP:0010472)1.67815751
124Soft skin (HP:0000977)1.67783333
125Duplicated collecting system (HP:0000081)1.67205311
126Ureteral duplication (HP:0000073)1.67180997
127Subacute progressive viral hepatitis (HP:0006572)1.67137087
128Shallow orbits (HP:0000586)1.66944365
129Triphalangeal thumb (HP:0001199)1.66383696
130Horseshoe kidney (HP:0000085)1.65743476
131Pallor (HP:0000980)1.65535293
132Down-sloping shoulders (HP:0200021)1.65017600
133Hypoplastic female external genitalia (HP:0012815)1.64723435
134Proximal placement of thumb (HP:0009623)1.64236543
135Arteriovenous malformation (HP:0100026)1.63086426
136Abnormality of the fingertips (HP:0001211)1.62975547
137Missing ribs (HP:0000921)1.62958630
138Vertebral compression fractures (HP:0002953)1.62873096
139Postnatal microcephaly (HP:0005484)1.62499491
140Abnormality of the frontal sinuses (HP:0002687)1.62216237
141* Increased number of teeth (HP:0011069)1.61676303
142Nephroblastoma (Wilms tumor) (HP:0002667)1.60238471
143Abnormality of the phalanges of the hallux (HP:0010057)1.60061675
144Distal lower limb muscle weakness (HP:0009053)1.60038983
145Asymmetry of the thorax (HP:0001555)1.59855348
146Aplastic anemia (HP:0001915)1.58473057
147Patchy hypopigmentation of hair (HP:0011365)1.57246583
148Increased density of long bones (HP:0006392)1.56612848
149Hypochromic anemia (HP:0001931)1.55427179
150Abnormality of the ileum (HP:0001549)1.54802201
151Abnormality of the preputium (HP:0100587)1.53044933
152Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.51885052
153Short 5th finger (HP:0009237)1.51394097
154Intestinal fistula (HP:0100819)1.51354612
155Popliteal pterygium (HP:0009756)1.51196598
156Rectal fistula (HP:0100590)1.51033961
157Rectovaginal fistula (HP:0000143)1.51033961
158Meckel diverticulum (HP:0002245)1.50817122
159Prostate neoplasm (HP:0100787)1.50546306
160Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.50434461
161Erythema (HP:0010783)1.50399579
162Myositis (HP:0100614)1.49112138
163Dislocated radial head (HP:0003083)1.48810354
164Embryonal renal neoplasm (HP:0011794)1.48543818
165Milia (HP:0001056)1.48061253
166Sparse lateral eyebrow (HP:0005338)1.47857206
167Colon cancer (HP:0003003)1.47356341
168Ankle contracture (HP:0006466)1.44541129
169Trigonocephaly (HP:0000243)1.44104228
170Recurrent abscess formation (HP:0002722)1.43790721
171Atresia of the external auditory canal (HP:0000413)1.43492352
172Type 1 muscle fiber predominance (HP:0003803)1.43373820
173IgA deficiency (HP:0002720)1.43318779
174Cutaneous melanoma (HP:0012056)1.43089109
175Broad toe (HP:0001837)1.42403659
176Trismus (HP:0000211)1.42011491
177Broad palm (HP:0001169)1.41755775
178Myelodysplasia (HP:0002863)1.41556975
179Large earlobe (HP:0009748)1.40977870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.44710383
2STK33.12937922
3NEK12.73558020
4CDC72.68504434
5TSSK62.66908674
6STK242.65019889
7TRIM282.61878849
8PIM22.44645405
9CDK122.36690848
10MKNK12.35425590
11PBK2.28767436
12TRPM72.25601838
13MKNK22.12901884
14MAP3K142.10749983
15TAF12.04684916
16SCYL21.97678455
17ERBB31.96355278
18STK101.96291386
19ZAK1.91571291
20LATS11.86859317
21NUAK11.80151359
22NME21.78200507
23STK41.77798631
24EIF2AK11.65993991
25VRK21.63894453
26PIM11.60578314
27EIF2AK21.60439944
28SRPK11.56303428
29MAP3K101.55350098
30TTK1.54195253
31NEK91.52429107
32RPS6KA41.50316129
33CDK61.48452894
34RPS6KB21.36168554
35BRD41.34993968
36BRSK21.34315505
37PLK41.34028915
38CDK71.31463919
39WNK31.26142567
40WEE11.24191890
41CDK41.22711894
42CHUK1.22263328
43IKBKB1.20792731
44TLK11.19271828
45ATR1.18796619
46AURKB1.16444024
47SMG11.10270214
48ERBB41.06370377
49ACVR1B1.05757961
50BRSK11.04283566
51NEK21.03572325
52TBK11.03355769
53PNCK1.03051147
54IRAK41.02167763
55STK160.99183030
56EPHB20.98428721
57PLK10.95967513
58JAK30.94175677
59TTN0.92275066
60YES10.91922280
61PAK40.89412072
62TEC0.89114194
63LRRK20.86575665
64ATM0.85465144
65MATK0.85119249
66VRK10.82706569
67CDK80.81746937
68PLK30.81398435
69CLK10.81109765
70TNIK0.81025107
71MST40.77537968
72FRK0.77421501
73DMPK0.77242363
74DDR20.76198865
75BMX0.75894291
76PLK20.75672986
77CHEK10.73560842
78TXK0.72852577
79MST1R0.72762677
80RAF10.72213924
81CHEK20.71357657
82PTK60.71213039
83MET0.70514761
84PASK0.69303006
85TGFBR10.69058121
86DYRK30.68884705
87FGFR10.66360239
88MAPKAPK20.64629248
89MAP2K30.64467014
90CAMK1G0.64321724
91KSR10.64251268
92SIK30.62678444
93EIF2AK30.62021314
94STK38L0.60366332
95MAP3K80.59764906
96MAP3K30.59046392
97CDK10.58320974
98IRAK30.56380040
99MAP3K50.56304262
100NME10.56023532
101MAP3K60.56021097
102PAK20.55108834
103RPS6KA50.55072615
104TGFBR20.54284032
105ALK0.53256277
106BCR0.52696792
107RPS6KC10.52383547
108RPS6KL10.52383547
109MAP3K110.50717896
110MAPKAPK30.50296206
111LATS20.49060728
112PKN20.48882541
113NLK0.48790495
114CDK20.48598992
115TYK20.48468269
116RPS6KA60.47413319
117CAMK1D0.46323956
118OBSCN0.46316224
119FGFR30.46182668
120MELK0.46060236
121MAP3K120.45846383
122CSNK2A10.44909126
123EEF2K0.44180589
124AURKA0.43830644
125CSK0.43371718
126RPS6KB10.42991511
127BMPR1B0.42136147
128BTK0.40386683
129BRAF0.38940943
130CSNK2A20.38648239
131EPHA20.38075237
132CCNB10.32992684
133PRKDC0.32421533
134CSNK1E0.31671324
135AKT20.31353241
136CDK90.30852578
137PRKD30.27240310
138FLT30.26325278
139CDK30.22490722

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.88979644
2Ribosome_Homo sapiens_hsa030102.40823077
3Mismatch repair_Homo sapiens_hsa034302.35549720
4Homologous recombination_Homo sapiens_hsa034402.15980772
5Cell cycle_Homo sapiens_hsa041102.11230529
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02145696
7Base excision repair_Homo sapiens_hsa034102.00458881
8Steroid biosynthesis_Homo sapiens_hsa001001.87115350
9Spliceosome_Homo sapiens_hsa030401.81105761
10Nucleotide excision repair_Homo sapiens_hsa034201.80421647
11p53 signaling pathway_Homo sapiens_hsa041151.77284974
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70457790
13Fanconi anemia pathway_Homo sapiens_hsa034601.68479679
14RNA transport_Homo sapiens_hsa030131.65869390
15Cysteine and methionine metabolism_Homo sapiens_hsa002701.63991262
16Graft-versus-host disease_Homo sapiens_hsa053321.61332504
17One carbon pool by folate_Homo sapiens_hsa006701.60784853
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58784148
19Herpes simplex infection_Homo sapiens_hsa051681.58238861
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56183238
21Viral myocarditis_Homo sapiens_hsa054161.53889644
22Small cell lung cancer_Homo sapiens_hsa052221.50567662
23Protein export_Homo sapiens_hsa030601.49440154
24Allograft rejection_Homo sapiens_hsa053301.48983797
25Non-homologous end-joining_Homo sapiens_hsa034501.46428418
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.41913462
27Leishmaniasis_Homo sapiens_hsa051401.39583772
28RNA degradation_Homo sapiens_hsa030181.39151781
29RNA polymerase_Homo sapiens_hsa030201.39056650
30Proteasome_Homo sapiens_hsa030501.37409314
31MicroRNAs in cancer_Homo sapiens_hsa052061.34795905
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33890926
33Pyruvate metabolism_Homo sapiens_hsa006201.33315199
34Adherens junction_Homo sapiens_hsa045201.30092139
35Measles_Homo sapiens_hsa051621.29280612
36Selenocompound metabolism_Homo sapiens_hsa004501.29265905
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28699895
38Legionellosis_Homo sapiens_hsa051341.26873967
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.26577271
40Basal transcription factors_Homo sapiens_hsa030221.22585631
41Malaria_Homo sapiens_hsa051441.19260512
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17457003
43TGF-beta signaling pathway_Homo sapiens_hsa043501.17417804
44Oocyte meiosis_Homo sapiens_hsa041141.16613747
45mRNA surveillance pathway_Homo sapiens_hsa030151.16344864
46Autoimmune thyroid disease_Homo sapiens_hsa053201.15352276
47Viral carcinogenesis_Homo sapiens_hsa052031.15117163
48Toxoplasmosis_Homo sapiens_hsa051451.14544046
49Hematopoietic cell lineage_Homo sapiens_hsa046401.11925608
50ECM-receptor interaction_Homo sapiens_hsa045121.11789649
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11319313
52Basal cell carcinoma_Homo sapiens_hsa052171.10678164
53Biosynthesis of amino acids_Homo sapiens_hsa012301.10665336
54Antigen processing and presentation_Homo sapiens_hsa046121.10605326
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07627065
56Vitamin B6 metabolism_Homo sapiens_hsa007501.05878089
57Systemic lupus erythematosus_Homo sapiens_hsa053221.05421460
58Apoptosis_Homo sapiens_hsa042101.05332846
59HTLV-I infection_Homo sapiens_hsa051661.05067557
60Epstein-Barr virus infection_Homo sapiens_hsa051691.04950740
61Pyrimidine metabolism_Homo sapiens_hsa002401.04677622
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04584988
63Hippo signaling pathway_Homo sapiens_hsa043901.04526021
64Hepatitis B_Homo sapiens_hsa051611.00698042
65TNF signaling pathway_Homo sapiens_hsa046681.00214757
66Propanoate metabolism_Homo sapiens_hsa006400.97362092
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97156659
68Influenza A_Homo sapiens_hsa051640.95987911
69Chronic myeloid leukemia_Homo sapiens_hsa052200.95985083
70Proteoglycans in cancer_Homo sapiens_hsa052050.92905384
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92635710
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92381641
73Carbon metabolism_Homo sapiens_hsa012000.92329027
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90389699
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90211833
76Fatty acid elongation_Homo sapiens_hsa000620.90117142
77Shigellosis_Homo sapiens_hsa051310.89960370
78Purine metabolism_Homo sapiens_hsa002300.89778366
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88831462
80Thyroid cancer_Homo sapiens_hsa052160.87554399
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86109183
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.86109150
83Asthma_Homo sapiens_hsa053100.85857063
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.85362248
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82761028
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.81319491
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80866400
88Pathways in cancer_Homo sapiens_hsa052000.80865375
89Primary immunodeficiency_Homo sapiens_hsa053400.79802452
90Focal adhesion_Homo sapiens_hsa045100.78294938
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77884080
92Glutathione metabolism_Homo sapiens_hsa004800.77539074
93Prostate cancer_Homo sapiens_hsa052150.77209579
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76528744
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74542726
96Notch signaling pathway_Homo sapiens_hsa043300.73732597
97N-Glycan biosynthesis_Homo sapiens_hsa005100.73021919
98Acute myeloid leukemia_Homo sapiens_hsa052210.72861187
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71916797
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70404940
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69006658
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68306894
103Arachidonic acid metabolism_Homo sapiens_hsa005900.68079692
104Bladder cancer_Homo sapiens_hsa052190.67128089
105Salmonella infection_Homo sapiens_hsa051320.67003971
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66574195
107Pertussis_Homo sapiens_hsa051330.66479731
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64980330
109Alcoholism_Homo sapiens_hsa050340.64189818
110Melanoma_Homo sapiens_hsa052180.63512966
111Tuberculosis_Homo sapiens_hsa051520.62310354
112Amoebiasis_Homo sapiens_hsa051460.61906745
113Hedgehog signaling pathway_Homo sapiens_hsa043400.61850193
114Colorectal cancer_Homo sapiens_hsa052100.60611672
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58165621
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58043072
117Osteoclast differentiation_Homo sapiens_hsa043800.57498786
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55683748
119Pancreatic cancer_Homo sapiens_hsa052120.55311628
120HIF-1 signaling pathway_Homo sapiens_hsa040660.54172761
121Phototransduction_Homo sapiens_hsa047440.53937738
122Wnt signaling pathway_Homo sapiens_hsa043100.53659534
123Dilated cardiomyopathy_Homo sapiens_hsa054140.52134943
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52096111
125Platelet activation_Homo sapiens_hsa046110.51723811
126Lysine degradation_Homo sapiens_hsa003100.51072892
127FoxO signaling pathway_Homo sapiens_hsa040680.50927785
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50395150
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49260303
130Folate biosynthesis_Homo sapiens_hsa007900.44818207
131Fatty acid metabolism_Homo sapiens_hsa012120.42747862
132Non-small cell lung cancer_Homo sapiens_hsa052230.41677144
133Huntingtons disease_Homo sapiens_hsa050160.38309897
134Endometrial cancer_Homo sapiens_hsa052130.38271440
135Metabolic pathways_Homo sapiens_hsa011000.38080946
136Pentose phosphate pathway_Homo sapiens_hsa000300.34440336
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34381478
138Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32044153
139Tight junction_Homo sapiens_hsa045300.30813509
140Sulfur metabolism_Homo sapiens_hsa009200.30753047
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28811212
142Vitamin digestion and absorption_Homo sapiens_hsa049770.26507905
143Renal cell carcinoma_Homo sapiens_hsa052110.23848059
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22754785
145Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21078058
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20342890
147Galactose metabolism_Homo sapiens_hsa000520.17418552
148Glioma_Homo sapiens_hsa052140.17327353
149Inositol phosphate metabolism_Homo sapiens_hsa005620.12921909

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