AMMECR1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.06537987
2L-phenylalanine catabolic process (GO:0006559)6.06537987
3L-phenylalanine metabolic process (GO:0006558)5.73396057
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.73396057
5aromatic amino acid family catabolic process (GO:0009074)5.52550952
6serine family amino acid catabolic process (GO:0009071)5.47626262
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.45269297
8cysteine metabolic process (GO:0006534)5.35920322
9urea metabolic process (GO:0019627)5.21415917
10urea cycle (GO:0000050)5.21415917
11tryptophan catabolic process (GO:0006569)5.08286949
12indole-containing compound catabolic process (GO:0042436)5.08286949
13indolalkylamine catabolic process (GO:0046218)5.08286949
14alpha-linolenic acid metabolic process (GO:0036109)5.07192109
15peptidyl-glutamic acid carboxylation (GO:0017187)4.93537943
16protein carboxylation (GO:0018214)4.93537943
17kynurenine metabolic process (GO:0070189)4.93449154
18tryptophan metabolic process (GO:0006568)4.92694797
19negative regulation of fibrinolysis (GO:0051918)4.83178331
20bile acid biosynthetic process (GO:0006699)4.76353299
21nitrogen cycle metabolic process (GO:0071941)4.70701475
22glycine metabolic process (GO:0006544)4.66947155
23embryonic process involved in female pregnancy (GO:0060136)4.66907842
24nuclear pore complex assembly (GO:0051292)4.66229831
25glyoxylate metabolic process (GO:0046487)4.65438429
26regulation of fibrinolysis (GO:0051917)4.57090889
27sulfur amino acid catabolic process (GO:0000098)4.55901636
28regulation of triglyceride catabolic process (GO:0010896)4.52312994
29complement activation, alternative pathway (GO:0006957)4.48103761
30regulation of protein activation cascade (GO:2000257)4.42231620
31amino-acid betaine metabolic process (GO:0006577)4.42154811
32hemidesmosome assembly (GO:0031581)4.38384599
33COPI coating of Golgi vesicle (GO:0048205)4.35628770
34Golgi transport vesicle coating (GO:0048200)4.35628770
35high-density lipoprotein particle remodeling (GO:0034375)4.34551939
36serine family amino acid metabolic process (GO:0009069)4.24431377
37homocysteine metabolic process (GO:0050667)4.23988612
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.19842786
39bile acid metabolic process (GO:0008206)4.12640327
40regulation of complement activation (GO:0030449)4.10139667
41aromatic amino acid family metabolic process (GO:0009072)4.04850642
42negative regulation of sterol transport (GO:0032372)4.04297942
43negative regulation of cholesterol transport (GO:0032375)4.04297942
44reverse cholesterol transport (GO:0043691)3.95153538
45triglyceride homeostasis (GO:0070328)3.90023478
46acylglycerol homeostasis (GO:0055090)3.90023478
47mitotic chromosome condensation (GO:0007076)3.86946000
48tyrosine metabolic process (GO:0006570)3.85516535
49plasma lipoprotein particle remodeling (GO:0034369)3.82771185
50protein-lipid complex remodeling (GO:0034368)3.82771185
51macromolecular complex remodeling (GO:0034367)3.82771185
52regulation of RNA export from nucleus (GO:0046831)3.82431558
53alpha-amino acid catabolic process (GO:1901606)3.80443161
54regulation of NFAT protein import into nucleus (GO:0051532)3.78346415
55plasma lipoprotein particle clearance (GO:0034381)3.77750347
56lysine metabolic process (GO:0006553)3.76739881
57lysine catabolic process (GO:0006554)3.76739881
58serine family amino acid biosynthetic process (GO:0009070)3.71442610
59urate metabolic process (GO:0046415)3.70901071
60regulation of cholesterol esterification (GO:0010872)3.70197810
61nuclear pore organization (GO:0006999)3.68373381
62bile acid and bile salt transport (GO:0015721)3.67697141
63cellular ketone body metabolic process (GO:0046950)3.66900134
64positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.62761814
65positive regulation of lipid catabolic process (GO:0050996)3.62597231
66plasma lipoprotein particle assembly (GO:0034377)3.55555533
67cell adhesion mediated by integrin (GO:0033627)3.54986199
68positive regulation of fatty acid beta-oxidation (GO:0032000)3.53427849
69cell-substrate junction assembly (GO:0007044)3.52377524
70cellular glucuronidation (GO:0052695)3.51646422
71phospholipid efflux (GO:0033700)3.51355229
72indolalkylamine metabolic process (GO:0006586)3.50897997
73ethanol oxidation (GO:0006069)3.45356674
74fibrinolysis (GO:0042730)3.42800207
75adherens junction assembly (GO:0034333)3.40000979
76cellular amino acid catabolic process (GO:0009063)3.39677415
77regulation of cholesterol homeostasis (GO:2000188)3.38903852
78arginine metabolic process (GO:0006525)3.37395267
79pore complex assembly (GO:0046931)3.36861268
80cholesterol efflux (GO:0033344)3.34458553
81drug catabolic process (GO:0042737)3.32446553
82glutamate metabolic process (GO:0006536)3.30142961
83regulation of nucleobase-containing compound transport (GO:0032239)3.29505127
84imidazole-containing compound metabolic process (GO:0052803)3.27784933
85cholesterol homeostasis (GO:0042632)3.27487144
86amine catabolic process (GO:0009310)3.27452518
87cellular biogenic amine catabolic process (GO:0042402)3.27452518
88positive regulation of lipoprotein lipase activity (GO:0051006)3.27385723
89positive regulation of triglyceride lipase activity (GO:0061365)3.27385723
90sterol homeostasis (GO:0055092)3.27136106
91skin morphogenesis (GO:0043589)3.26037539
92protein-lipid complex assembly (GO:0065005)3.22755492
93benzene-containing compound metabolic process (GO:0042537)3.20869348
94vitamin transmembrane transport (GO:0035461)3.19450169
953-UTR-mediated mRNA stabilization (GO:0070935)3.18602252
96midgut development (GO:0007494)3.17897273
97pinocytosis (GO:0006907)3.16903111
98linoleic acid metabolic process (GO:0043651)3.14960119
99cellular modified amino acid catabolic process (GO:0042219)3.14743035
100low-density lipoprotein particle remodeling (GO:0034374)3.14639569
101carnitine metabolic process (GO:0009437)3.12973769
102protein localization to endosome (GO:0036010)3.10999487
103coenzyme catabolic process (GO:0009109)3.10084936
104regulation of bile acid biosynthetic process (GO:0070857)3.09759910
105negative regulation of lipase activity (GO:0060192)3.08647412
106lipoprotein metabolic process (GO:0042157)3.08441101
107regulation of plasminogen activation (GO:0010755)3.08132106
108cell-substrate adherens junction assembly (GO:0007045)3.07937089
109focal adhesion assembly (GO:0048041)3.07937089
110phospholipid homeostasis (GO:0055091)3.07605431
111regulation of vitamin D biosynthetic process (GO:0060556)3.07375579
112positive regulation of triglyceride metabolic process (GO:0090208)3.07050258
113response to nitrosative stress (GO:0051409)3.05816925
114ketone body metabolic process (GO:1902224)3.05065520
115plasma lipoprotein particle organization (GO:0071827)3.04650609
116blood coagulation, intrinsic pathway (GO:0007597)3.02893013
117maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.02039416
118uronic acid metabolic process (GO:0006063)3.01098239
119glucuronate metabolic process (GO:0019585)3.01098239
120paraxial mesoderm development (GO:0048339)3.00515155
121very-low-density lipoprotein particle assembly (GO:0034379)2.99164539
122acute-phase response (GO:0006953)2.98110184
123regulation of fatty acid beta-oxidation (GO:0031998)2.97907372
124polarized epithelial cell differentiation (GO:0030859)2.95465906
125spliceosomal tri-snRNP complex assembly (GO:0000244)2.93996924
126positive regulation of keratinocyte differentiation (GO:0045618)2.92781624
127regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.83369386
128regulation of mammary gland epithelial cell proliferation (GO:0033599)2.83326506
129mRNA transcription from RNA polymerase II promoter (GO:0042789)2.83295366
130trophectodermal cell differentiation (GO:0001829)2.82767630
131regulation of chromatin binding (GO:0035561)2.78754275
132low-density lipoprotein particle clearance (GO:0034383)2.78687077
133mRNA stabilization (GO:0048255)2.76317735
134RNA stabilization (GO:0043489)2.76317735
135dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.73311879
136regulation of histone H3-K27 methylation (GO:0061085)2.71824134
137dosage compensation (GO:0007549)2.71426291
138COPII vesicle coating (GO:0048208)2.70709405
139regulation of transcription from RNA polymerase I promoter (GO:0006356)2.70522113
140mRNA transcription (GO:0009299)2.69928794
141mammary gland epithelial cell proliferation (GO:0033598)2.69874351
142regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.67792802
143protein retention in ER lumen (GO:0006621)2.67599311
144endodermal cell differentiation (GO:0035987)2.64665612
145trophoblast giant cell differentiation (GO:0060707)2.64492036
146hippo signaling (GO:0035329)2.62622239
147regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.60236710
148positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59745923
149stress fiber assembly (GO:0043149)2.59037751
150basement membrane organization (GO:0071711)2.58385647
151heterochromatin organization (GO:0070828)2.53206699
152cellular protein complex localization (GO:0034629)2.52377620
153regulation of transforming growth factor beta2 production (GO:0032909)2.51432922
154endoplasmic reticulum unfolded protein response (GO:0030968)2.50496210
155protein export from nucleus (GO:0006611)2.48206910
156planar cell polarity pathway involved in neural tube closure (GO:0090179)2.48193933
157retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47425082
158protein localization to chromosome, centromeric region (GO:0071459)2.46240493
159positive regulation of nuclease activity (GO:0032075)2.44674218
160activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.43387779
161ER-nucleus signaling pathway (GO:0006984)2.43139913
162regulation of early endosome to late endosome transport (GO:2000641)2.41513096
163histone H3-K36 demethylation (GO:0070544)2.40184429
164embryonic heart tube development (GO:0035050)2.39769497
165chromosome condensation (GO:0030261)2.39380640
166positive regulation of blood vessel endothelial cell migration (GO:0043536)2.34815148
167blood vessel endothelial cell migration (GO:0043534)2.33685201
168protein complex localization (GO:0031503)2.33460023
169proline biosynthetic process (GO:0006561)2.33287460
170wound healing, spreading of epidermal cells (GO:0035313)2.31813628
171epithelial cell-cell adhesion (GO:0090136)2.31281822
172cellular response to unfolded protein (GO:0034620)2.30350557
173negative regulation of fatty acid transport (GO:2000192)2.29841570
174negative regulation of erythrocyte differentiation (GO:0045647)2.28873790
175epithelial cell differentiation involved in prostate gland development (GO:0060742)2.28539929
176desmosome organization (GO:0002934)2.28444386
177regulation of vitamin metabolic process (GO:0030656)2.28372648
178regulation of nuclease activity (GO:0032069)2.27713475
179DNA unwinding involved in DNA replication (GO:0006268)2.27566373
180negative regulation of histone methylation (GO:0031061)2.26501536
181nuclear envelope disassembly (GO:0051081)2.24057692
182membrane disassembly (GO:0030397)2.24057692
183hyaluronan catabolic process (GO:0030214)2.23639964
184positive regulation of endothelial cell apoptotic process (GO:2000353)2.21162627
185regulation of DNA damage checkpoint (GO:2000001)2.19896247
186regulation of glucose import in response to insulin stimulus (GO:2001273)2.19561821
187ribosome assembly (GO:0042255)2.19394473
188positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.18554907
189positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.18494371
190regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.18455582
191positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.18079503
192mitotic nuclear envelope disassembly (GO:0007077)2.17540641
193mitotic metaphase plate congression (GO:0007080)2.17016809
194histone lysine demethylation (GO:0070076)2.16436705
195response to laminar fluid shear stress (GO:0034616)2.13949608
196membrane protein ectodomain proteolysis (GO:0006509)2.12883194
197peptidyl-lysine dimethylation (GO:0018027)2.12125445
198branching involved in mammary gland duct morphogenesis (GO:0060444)2.11934180
199hypotonic response (GO:0006971)2.09244721
200vesicle coating (GO:0006901)2.08851713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.94827783
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.13687484
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.10713640
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.53999794
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.53822919
6TP63_17297297_ChIP-ChIP_HaCaT_Human5.20029022
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.18459328
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.78247386
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.64783208
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.52338224
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.17348817
12MYC_22102868_ChIP-Seq_BL_Human2.57241563
13CLOCK_20551151_ChIP-Seq_293T_Human2.38520130
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.25950733
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.19864559
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17549273
17AR_21909140_ChIP-Seq_LNCAP_Human2.11799809
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91251499
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.89239345
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.89058788
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86838779
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86652654
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86292850
24VDR_21846776_ChIP-Seq_THP-1_Human1.84759519
25* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.81503764
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.79856204
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78200543
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76890138
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75895024
30* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72937341
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.71660963
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70226179
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69586683
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68894355
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.64395766
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61953412
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.60184441
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59112310
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57868063
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.56969622
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55631958
42CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50464220
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49779608
44TFEB_21752829_ChIP-Seq_HELA_Human1.49413924
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.47776836
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46744561
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46744561
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46744561
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45266092
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42934537
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42026511
52RACK7_27058665_Chip-Seq_MCF-7_Human1.41605021
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41170669
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40341157
55HNF4A_19822575_ChIP-Seq_HepG2_Human1.38820752
56HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38739427
57KDM2B_26808549_Chip-Seq_DND41_Human1.38236999
58KAP1_22055183_ChIP-Seq_ESCs_Mouse1.38234876
59TP53_22127205_ChIP-Seq_IMR90_Human1.38122589
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.37081564
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37006910
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.30156936
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29503008
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28510967
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27286950
66ZNF263_19887448_ChIP-Seq_K562_Human1.24755228
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24423777
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22163327
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20993320
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20665644
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20233170
72DCP1A_22483619_ChIP-Seq_HELA_Human1.20219034
73EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20181391
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14627192
75GATA4_25053715_ChIP-Seq_YYC3_Human1.13732795
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11939627
77* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11510420
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11184738
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09912255
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09813298
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08611970
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08429334
83XRN2_22483619_ChIP-Seq_HELA_Human1.06868702
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06612168
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05330604
86KDM2B_26808549_Chip-Seq_K562_Human1.04807853
87MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04554344
88* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04506716
89IRF8_22096565_ChIP-ChIP_GC-B_Human1.02842441
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02792145
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01797347
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01070921
93* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99861569
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99821899
95CIITA_25753668_ChIP-Seq_RAJI_Human0.99709793
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99000178
97LXR_22292898_ChIP-Seq_THP-1_Human0.98991785
98VDR_24763502_ChIP-Seq_THP-1_Human0.97983150
99PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96342526
100SALL1_21062744_ChIP-ChIP_HESCs_Human0.96067206
101RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95169791
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92905484
103SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91174169
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90406561
105CHD1_26751641_Chip-Seq_LNCaP_Human0.89946686
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88743293
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87789778
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.87616010
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87331276
110FOXA1_25552417_ChIP-Seq_VCAP_Human0.84757708
111* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84623002
112GATA6_25053715_ChIP-Seq_YYC3_Human0.82583055
113* IRF8_27001747_Chip-Seq_BMDM_Mouse0.82044298
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.81302121
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81193794
116IRF8_21731497_ChIP-ChIP_J774_Mouse0.80129989
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79816234
118BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79119408
119SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78033227
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74170292
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73202320
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.73001912
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.72986623
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72947572
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.72354934
126* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70743232
127KDM5A_27292631_Chip-Seq_BREAST_Human0.69267261
128* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.69073285
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.67268496
130E2F7_22180533_ChIP-Seq_HELA_Human0.66130067
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66054150
132NFIB_24661679_ChIP-Seq_LUNG_Mouse0.64833717
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.64630527
134MYB_26560356_Chip-Seq_TH1_Human0.64022098
135KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.63994694
136SCL_19346495_ChIP-Seq_HPC-7_Human0.63306533
137* UBF1/2_26484160_Chip-Seq_HMECs_Human0.62555288
138ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.62319252
139STAT1_17558387_ChIP-Seq_HELA_Human0.62282659
140NCOR1_26117541_ChIP-Seq_K562_Human0.62265513
141* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.62011091
142ESR2_21235772_ChIP-Seq_MCF-7_Human0.61138180
143CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61007727
144RBPJ_22232070_ChIP-Seq_NCS_Mouse0.60451611
145HTT_18923047_ChIP-ChIP_STHdh_Human0.59632042
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.59556079
147FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.58633873
148RARB_24833708_ChIP-Seq_LIVER_Mouse0.58338915
149SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.57733593
150SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.57733593
151CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.57254886
152RARA_24833708_ChIP-Seq_LIVER_Mouse0.55629259
153NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.55291531
154KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.54831510
155KLF4_18555785_ChIP-Seq_MESCs_Mouse0.54538248
156ATF3_27146783_Chip-Seq_COLON_Human0.54411708
157VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.54047625
158TCF7_22412390_ChIP-Seq_EML_Mouse0.53086153
159BRD4_25478319_ChIP-Seq_HGPS_Human0.53075790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.16703565
2MP0005360_urolithiasis6.30826680
3MP0005365_abnormal_bile_salt5.06635407
4MP0005085_abnormal_gallbladder_physiolo4.71042518
5MP0008875_abnormal_xenobiotic_pharmacok4.02487878
6MP0003252_abnormal_bile_duct3.41672519
7MP0010329_abnormal_lipoprotein_level2.99598921
8MP0003566_abnormal_cell_adhesion2.87904306
9MP0008438_abnormal_cutaneous_collagen2.86490156
10MP0009840_abnormal_foam_cell2.73076406
11MP0002877_abnormal_melanocyte_morpholog2.70479819
12MP0004272_abnormal_basement_membrane2.63998710
13MP0005409_darkened_coat_color2.48343972
14MP0003806_abnormal_nucleotide_metabolis2.17101485
15MP0005257_abnormal_intraocular_pressure2.13499272
16MP0005332_abnormal_amino_acid2.10854093
17MP0001666_abnormal_nutrient_absorption2.06964679
18MP0000609_abnormal_liver_physiology2.01148195
19MP0001849_ear_inflammation1.98077197
20MP0004233_abnormal_muscle_weight1.97513665
21MP0003111_abnormal_nucleus_morphology1.94728753
22MP0002138_abnormal_hepatobiliary_system1.91788844
23MP0003705_abnormal_hypodermis_morpholog1.80861753
24MP0003091_abnormal_cell_migration1.80534154
25MP0003941_abnormal_skin_development1.76926963
26MP0005501_abnormal_skin_physiology1.74676518
27MP0003195_calcinosis1.72493357
28MP0002796_impaired_skin_barrier1.70441507
29MP0004019_abnormal_vitamin_homeostasis1.65644519
30MP0003868_abnormal_feces_composition1.65322612
31MP0003453_abnormal_keratinocyte_physiol1.60653960
32MP0003191_abnormal_cellular_cholesterol1.57900054
33MP0005058_abnormal_lysosome_morphology1.56097162
34MP0005083_abnormal_biliary_tract1.53692400
35MP0002118_abnormal_lipid_homeostasis1.53210018
36MP0001730_embryonic_growth_arrest1.51824230
37MP0003077_abnormal_cell_cycle1.49340822
38MP0008260_abnormal_autophagy1.46761830
39MP0004957_abnormal_blastocyst_morpholog1.40347105
40MP0005319_abnormal_enzyme/_coenzyme1.39148375
41MP0000678_abnormal_parathyroid_gland1.37031464
42MP0010307_abnormal_tumor_latency1.36685764
43MP0000350_abnormal_cell_proliferation1.35890105
44MP0000467_abnormal_esophagus_morphology1.35023378
45MP0005275_abnormal_skin_tensile1.34780850
46MP0005451_abnormal_body_composition1.32068349
47MP0009384_cardiac_valve_regurgitation1.31543947
48MP0009697_abnormal_copulation1.30510613
49MP0005621_abnormal_cell_physiology1.29442636
50MP0009053_abnormal_anal_canal1.29417176
51MP0000537_abnormal_urethra_morphology1.29343072
52MP0005408_hypopigmentation1.26302713
53MP0000598_abnormal_liver_morphology1.25517048
54MP0010094_abnormal_chromosome_stability1.25427389
55MP0008932_abnormal_embryonic_tissue1.25306445
56MP0000733_abnormal_muscle_development1.21307182
57MP0002653_abnormal_ependyma_morphology1.21126590
58MP0003693_abnormal_embryo_hatching1.20869716
59MP0001216_abnormal_epidermal_layer1.19836281
60MP0005623_abnormal_meninges_morphology1.16894383
61MP0001661_extended_life_span1.14814248
62MP0003718_maternal_effect1.12425092
63MP0004782_abnormal_surfactant_physiolog1.10910549
64MP0001879_abnormal_lymphatic_vessel1.10530021
65MP0003011_delayed_dark_adaptation1.09538898
66MP0002080_prenatal_lethality1.09279887
67MP0000003_abnormal_adipose_tissue1.09060077
68MP0001915_intracranial_hemorrhage1.08388336
69MP0000762_abnormal_tongue_morphology1.07238481
70MP0004197_abnormal_fetal_growth/weight/1.06324609
71MP0009764_decreased_sensitivity_to1.03724221
72MP0001697_abnormal_embryo_size1.02940104
73MP0000858_altered_metastatic_potential1.01981187
74MP0002254_reproductive_system_inflammat1.00154242
75MP0000627_abnormal_mammary_gland0.98358225
76MP0002089_abnormal_postnatal_growth/wei0.96843303
77MP0009643_abnormal_urine_homeostasis0.96016884
78MP0002132_abnormal_respiratory_system0.95401714
79MP0005384_cellular_phenotype0.95374015
80MP0002084_abnormal_developmental_patter0.93299363
81MP0005171_absent_coat_pigmentation0.92463372
82MP0003315_abnormal_perineum_morphology0.92351112
83MP0010630_abnormal_cardiac_muscle0.92101331
84MP0002085_abnormal_embryonic_tissue0.91959558
85MP0009763_increased_sensitivity_to0.91292619
86MP0005375_adipose_tissue_phenotype0.90377745
87MP0000490_abnormal_crypts_of0.90169098
88MP0005647_abnormal_sex_gland0.89944590
89MP0010368_abnormal_lymphatic_system0.89623178
90MP0003828_pulmonary_edema0.89250979
91MP0001243_abnormal_dermal_layer0.89045528
92MP0003385_abnormal_body_wall0.88821079
93MP0005220_abnormal_exocrine_pancreas0.88610905
94MP0009278_abnormal_bone_marrow0.88449780
95MP0001545_abnormal_hematopoietic_system0.88437601
96MP0005397_hematopoietic_system_phenotyp0.88437601
97MP0003172_abnormal_lysosome_physiology0.87779194
98MP0003656_abnormal_erythrocyte_physiolo0.87689809
99MP0003567_abnormal_fetal_cardiomyocyte0.86811571
100MP0005395_other_phenotype0.86232316
101MP0010771_integument_phenotype0.85878964
102MP0010352_gastrointestinal_tract_polyps0.85188613
103MP0005670_abnormal_white_adipose0.84449924
104MP0005508_abnormal_skeleton_morphology0.84054774
105MP0005187_abnormal_penis_morphology0.83430325
106MP0004381_abnormal_hair_follicle0.82478698
107MP0004808_abnormal_hematopoietic_stem0.82321468
108MP0002925_abnormal_cardiovascular_devel0.82178899
109MP0005584_abnormal_enzyme/coenzyme_acti0.81417445
110MP0008469_abnormal_protein_level0.78953474
111MP0002928_abnormal_bile_duct0.78870864
112MP0008057_abnormal_DNA_replication0.78715842
113MP0003186_abnormal_redox_activity0.78169157
114MP0004130_abnormal_muscle_cell0.77679714
115MP0005248_abnormal_Harderian_gland0.77113720
116MP0004264_abnormal_extraembryonic_tissu0.76045391
117MP0002896_abnormal_bone_mineralization0.75965778
118MP0000579_abnormal_nail_morphology0.75661427
119MP0005076_abnormal_cell_differentiation0.75102184
120MP0001614_abnormal_blood_vessel0.74474341
121MP0002697_abnormal_eye_size0.74357706
122MP0000313_abnormal_cell_death0.73711629
123MP0003436_decreased_susceptibility_to0.73146074
124MP0003943_abnormal_hepatobiliary_system0.73009407
125MP0002971_abnormal_brown_adipose0.72577943
126MP0003724_increased_susceptibility_to0.71552896
127MP0002092_abnormal_eye_morphology0.70309354
128MP0009672_abnormal_birth_weight0.69552120
129MP0005666_abnormal_adipose_tissue0.68999829
130MP0002282_abnormal_trachea_morphology0.68141697
131MP0003115_abnormal_respiratory_system0.68138069
132MP0001293_anophthalmia0.66061438
133MP0003221_abnormal_cardiomyocyte_apopto0.65634700
134MP0003303_peritoneal_inflammation0.65377178
135MP0002060_abnormal_skin_morphology0.64334684
136MP0009642_abnormal_blood_homeostasis0.64052599
137MP0003300_gastrointestinal_ulcer0.63006650
138MP0004185_abnormal_adipocyte_glucose0.61624733
139MP0005636_abnormal_mineral_homeostasis0.60951045
140MP0005464_abnormal_platelet_physiology0.60355485
141MP0000767_abnormal_smooth_muscle0.59593693
142MP0002136_abnormal_kidney_physiology0.58839505
143MP0001764_abnormal_homeostasis0.58176956
144MP0003699_abnormal_female_reproductive0.57474442
145MP0000462_abnormal_digestive_system0.56966177
146MP0002088_abnormal_embryonic_growth/wei0.55629972
147MP0001881_abnormal_mammary_gland0.55049633
148MP0005334_abnormal_fat_pad0.53802887
149MP0005023_abnormal_wound_healing0.53554660
150MP0001119_abnormal_female_reproductive0.53453096
151MP0010234_abnormal_vibrissa_follicle0.53304953
152MP0002135_abnormal_kidney_morphology0.52645730
153MP0003984_embryonic_growth_retardation0.52434473
154MP0009115_abnormal_fat_cell0.51419268
155MP0001672_abnormal_embryogenesis/_devel0.51400830
156MP0005380_embryogenesis_phenotype0.51400830
157MP0002938_white_spotting0.50142298
158MP0002098_abnormal_vibrissa_morphology0.49488401
159MP0000377_abnormal_hair_follicle0.48333030
160MP0002168_other_aberrant_phenotype0.48272962
161MP0004947_skin_inflammation0.47939957
162MP0008007_abnormal_cellular_replicative0.47931527
163MP0003942_abnormal_urinary_system0.47652993
164MP0002086_abnormal_extraembryonic_tissu0.47063206

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.87585846
2Intrahepatic cholestasis (HP:0001406)6.03854213
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.95057848
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.71719217
5Xanthomatosis (HP:0000991)5.31322289
6Prolonged partial thromboplastin time (HP:0003645)5.13721631
7Hyperlipoproteinemia (HP:0010980)4.77886379
8Hypobetalipoproteinemia (HP:0003563)4.75159177
9Complement deficiency (HP:0004431)4.35296228
10Hyperglycinemia (HP:0002154)4.30627721
11Hyperglycinuria (HP:0003108)4.18610111
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.93158889
13Joint hemorrhage (HP:0005261)3.91638572
14Hyperammonemia (HP:0001987)3.90520366
15Abnormality of the common coagulation pathway (HP:0010990)3.89730394
16Abnormality of glycine metabolism (HP:0010895)3.82727179
17Abnormality of serine family amino acid metabolism (HP:0010894)3.82727179
18Hypolipoproteinemia (HP:0010981)3.79956372
19Hypercholesterolemia (HP:0003124)3.76346592
20Hypoalphalipoproteinemia (HP:0003233)3.65303432
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.65041818
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.54653879
23Premature rupture of membranes (HP:0001788)3.53481789
24Protrusio acetabuli (HP:0003179)3.49383204
25Epidermoid cyst (HP:0200040)3.48567372
26Myocardial infarction (HP:0001658)3.44624000
27Ketosis (HP:0001946)3.33219965
28Syringomyelia (HP:0003396)3.19233281
29Spinal cord lesions (HP:0100561)3.19233281
30Spontaneous abortion (HP:0005268)3.15837088
31Atrophic scars (HP:0001075)3.15626795
32Hypoglycemic coma (HP:0001325)3.14927834
33Fat malabsorption (HP:0002630)3.08264111
34Abnormality of complement system (HP:0005339)3.06645112
35Abnormality of pyrimidine metabolism (HP:0004353)3.03577135
36Abnormality of the intrinsic pathway (HP:0010989)3.01304971
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.99700121
38Gout (HP:0001997)2.89666990
39Thin bony cortex (HP:0002753)2.83891067
40Abnormality of methionine metabolism (HP:0010901)2.79988517
41Hepatocellular carcinoma (HP:0001402)2.77879827
42Abnormality of serum amino acid levels (HP:0003112)2.77638938
43Abnormality of nucleobase metabolism (HP:0010932)2.77635590
44Conjugated hyperbilirubinemia (HP:0002908)2.66125011
45Spinal rigidity (HP:0003306)2.65449343
46Abnormality of purine metabolism (HP:0004352)2.64664818
47Mitral stenosis (HP:0001718)2.57792395
48Peritonitis (HP:0002586)2.57302471
49Esophageal varix (HP:0002040)2.51218720
50Vertebral arch anomaly (HP:0008438)2.48711517
51Deviation of the thumb (HP:0009603)2.47708579
52Hyperacusis (HP:0010780)2.47686568
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.45222180
54Abnormality of fatty-acid metabolism (HP:0004359)2.43184062
55Asymmetry of the thorax (HP:0001555)2.42616245
56Ulnar bowing (HP:0003031)2.41411349
57Gingival bleeding (HP:0000225)2.37790341
58Selective tooth agenesis (HP:0001592)2.36756587
59Recurrent gram-negative bacterial infections (HP:0005420)2.35641005
60Spastic diplegia (HP:0001264)2.29926018
61Systemic lupus erythematosus (HP:0002725)2.29269076
62Vascular calcification (HP:0004934)2.29183894
63Broad face (HP:0000283)2.29157944
64Follicular hyperkeratosis (HP:0007502)2.27850320
65Entropion (HP:0000621)2.24684245
66Vertebral compression fractures (HP:0002953)2.24343988
67Milia (HP:0001056)2.23528928
68Nonimmune hydrops fetalis (HP:0001790)2.22244677
69Hemorrhage of the eye (HP:0011885)2.21272885
70Fragile skin (HP:0001030)2.20340535
71Cardiovascular calcification (HP:0011915)2.20188551
72Back pain (HP:0003418)2.19155192
73Steatorrhea (HP:0002570)2.17781163
74Thrombophlebitis (HP:0004418)2.16029962
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.12559893
76Osteolytic defects of the hand bones (HP:0009699)2.12559893
77Hyperbilirubinemia (HP:0002904)2.12459053
78Proximal placement of thumb (HP:0009623)2.10591624
79Bladder diverticulum (HP:0000015)2.06556058
80Gastrointestinal infarctions (HP:0005244)2.06102110
81Flat acetabular roof (HP:0003180)2.02499489
82Heterotopia (HP:0002282)2.02330709
83Glomerulonephritis (HP:0000099)2.01536825
84Abnormality of the distal phalanx of the thumb (HP:0009617)2.00428098
85Hydroxyprolinuria (HP:0003080)2.00021916
86Abnormality of proline metabolism (HP:0010907)2.00021916
87Pigmentary retinal degeneration (HP:0001146)1.97945380
88Poikiloderma (HP:0001029)1.97209367
89Genu recurvatum (HP:0002816)1.97076409
90Achilles tendon contracture (HP:0001771)1.96963622
91Ketoacidosis (HP:0001993)1.93337563
92Difficulty climbing stairs (HP:0003551)1.91793253
93Coronal craniosynostosis (HP:0004440)1.91463574
94Long palpebral fissure (HP:0000637)1.91366527
95Alopecia of scalp (HP:0002293)1.91068348
96Enlarged kidneys (HP:0000105)1.90821123
97Abnormality of the calcaneus (HP:0008364)1.90039242
98Short nail (HP:0001799)1.89435398
99Mitral valve prolapse (HP:0001634)1.89319765
100Hyperglycemia (HP:0003074)1.88846605
101Abnormal cartilage morphology (HP:0002763)1.88831336
102Distal upper limb amyotrophy (HP:0007149)1.87747924
103Upper limb amyotrophy (HP:0009129)1.87747924
104Elbow flexion contracture (HP:0002987)1.87697162
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87543194
106Deep philtrum (HP:0002002)1.86714172
107Cortical dysplasia (HP:0002539)1.86683973
108Hypochromic microcytic anemia (HP:0004840)1.86266986
109Delayed CNS myelination (HP:0002188)1.86219463
110Progressive muscle weakness (HP:0003323)1.86068139
111Distal lower limb amyotrophy (HP:0008944)1.85921345
112Long toe (HP:0010511)1.85761995
113Acanthocytosis (HP:0001927)1.84867455
114Pseudobulbar signs (HP:0002200)1.84657370
115Abnormality of the Achilles tendon (HP:0005109)1.83661116
116Increased connective tissue (HP:0009025)1.83374238
117Ankyloglossia (HP:0010296)1.83183525
118Shoulder girdle muscle weakness (HP:0003547)1.82645880
119Wormian bones (HP:0002645)1.82200616
120Ankle contracture (HP:0006466)1.81985397
121Pancreatitis (HP:0001733)1.81620226
122Dicarboxylic aciduria (HP:0003215)1.80681901
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80681901
124Sensorimotor neuropathy (HP:0007141)1.80180361
125Dislocated radial head (HP:0003083)1.79969219
126Hyperuricemia (HP:0002149)1.79256501
127Increased purine levels (HP:0004368)1.79256501
128Tibial bowing (HP:0002982)1.78727525
129Abnormality of lateral ventricle (HP:0030047)1.78593345
130Flattened epiphyses (HP:0003071)1.78450385
131Skin nodule (HP:0200036)1.78321566
132Malnutrition (HP:0004395)1.76851493
133Polycythemia (HP:0001901)1.76063663
134Menorrhagia (HP:0000132)1.75375439
135Nephritis (HP:0000123)1.75148770
136Long eyelashes (HP:0000527)1.73889652
137Conjunctival telangiectasia (HP:0000524)1.73630552
138Small epiphyses (HP:0010585)1.73537916
139Cupped ribs (HP:0000887)1.73412320
140Ridged nail (HP:0001807)1.72640317
141Arterial tortuosity (HP:0005116)1.71086246
142Brushfield spots (HP:0001088)1.70964971
143Natal tooth (HP:0000695)1.70160194
144Scapular winging (HP:0003691)1.69869051
145Abnormality of the thoracic spine (HP:0100711)1.69767488
146Pelvic girdle muscle weakness (HP:0003749)1.69556151
147Vascular tortuosity (HP:0004948)1.68929196
148Metabolic acidosis (HP:0001942)1.68745408
149Pulmonary embolism (HP:0002204)1.68516683
150Abnormality of the radial head (HP:0003995)1.67881014
151Neonatal hypoglycemia (HP:0001998)1.67743431
152Abnormality of nail color (HP:0100643)1.67323703
153Abnormality of dentin (HP:0010299)1.67123703
154Mitral regurgitation (HP:0001653)1.65603340
155Abnormality of the fingertips (HP:0001211)1.65007429
156Centrally nucleated skeletal muscle fibers (HP:0003687)1.64788925
157Subacute progressive viral hepatitis (HP:0006572)1.64453759
158Abnormal ossification of hand bones (HP:0005921)1.64387520
159Abnormality of the acetabulum (HP:0003170)1.63817924
160Cervical subluxation (HP:0003308)1.63568927
161Uterine leiomyosarcoma (HP:0002891)1.63362522
162Leiomyosarcoma (HP:0100243)1.63362522
163Pustule (HP:0200039)1.62982421
164Abnormal enzyme/coenzyme activity (HP:0012379)1.62073652
165Stroke (HP:0001297)1.61635936
166Large earlobe (HP:0009748)1.61220813
167Right ventricular cardiomyopathy (HP:0011663)1.61025865
168Thick nail (HP:0001805)1.60791188
169Irritability (HP:0000737)1.60502863
170Fragile nails (HP:0001808)1.59279269
171Abnormality of oral frenula (HP:0000190)1.59147365
172Hammertoe (HP:0001765)1.58624358
173Amyloidosis (HP:0011034)1.56753238
174Overlapping toe (HP:0001845)1.56078755
175Hand muscle atrophy (HP:0009130)1.56064319
176High anterior hairline (HP:0009890)1.56011075
177Azoospermia (HP:0000027)1.55757354
178Abnormality of the distal phalanges of the toes (HP:0010182)1.55442090
179Disproportionate tall stature (HP:0001519)1.55386147
180Lethargy (HP:0001254)1.55281061
181Aortic dissection (HP:0002647)1.53831449
182Cubitus valgus (HP:0002967)1.53557132
183Sparse lateral eyebrow (HP:0005338)1.53285882
184Abnormality of pain sensation (HP:0010832)1.52853184
185Impaired pain sensation (HP:0007328)1.52853184
186Joint laxity (HP:0001388)1.51867759
187Nail dystrophy (HP:0008404)1.51540873
188Hypopigmentation of the fundus (HP:0007894)1.51454879
189Blue sclerae (HP:0000592)1.51090606
190Abnormality of the columella (HP:0009929)1.49896649
191Shallow orbits (HP:0000586)1.49858331
192Generalized amyotrophy (HP:0003700)1.49795364
193Rhizomelia (HP:0008905)1.49761765
194Onycholysis (HP:0001806)1.49675877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.25659994
2STK33.39479429
3SIK13.03955827
4ERN12.59632566
5PDGFRA2.51365101
6EPHA32.50195539
7IRAK32.47834963
8MAP3K62.45077073
9PRPF4B2.36925773
10MAP2K32.23630028
11FGFR42.19948607
12LATS22.15186311
13FRK2.10403427
14TRIB32.06958041
15NME22.06538823
16BRD42.06271511
17BRSK21.99419014
18MAP3K101.99103685
19ERBB41.97419689
20STK101.97288980
21SMG11.88903434
22TAOK31.80976508
23NEK91.79531260
24EPHB21.73270792
25PAK41.71256353
26PTK61.67669661
27TYK21.62243473
28PDK41.60149825
29PDK31.60149825
30STK38L1.55742673
31TAOK11.55551064
32NEK21.54164626
33PKN21.45000513
34EPHA21.42642772
35TTN1.42613919
36KSR21.41425230
37BCKDK1.37116481
38ICK1.34384859
39PTK21.30488131
40MET1.30459700
41CLK11.30313652
42PLK41.27218956
43DDR21.25180247
44FGFR21.22604718
45FGFR31.21154838
46SRPK11.19037825
47CDK61.18590168
48TTK1.16135793
49CDK91.15195586
50STK381.14482237
51MOS1.14320770
52MKNK21.13968688
53CDK41.12332850
54MARK31.12313839
55MAP3K51.11416552
56MAP3K131.11105989
57ERBB21.11001620
58TAOK21.09103527
59SCYL21.08561307
60NUAK11.06531456
61MTOR1.05941822
62TSSK61.04613589
63RPS6KA41.02671187
64STK241.02504980
65PIK3CG1.02113537
66RIPK11.00367366
67SIK30.98719331
68MAP3K30.92390877
69PIM20.92181111
70ARAF0.91332005
71MAP2K40.90693301
72MAP3K140.90303755
73WEE10.89382439
74DYRK30.88594285
75CHUK0.87707679
76PRKAA20.83769497
77PDGFRB0.83519772
78KIT0.76611049
79PBK0.76095873
80IRAK20.75977300
81NTRK10.73027956
82ABL20.72151209
83MKNK10.71376607
84MELK0.71159599
85MAP3K10.70631870
86MAPK110.70527217
87EEF2K0.69457854
88NLK0.69369562
89JAK20.67278633
90PLK10.62858777
91PRKAA10.62804422
92EPHB10.61884017
93PAK20.60641636
94ZAP700.59363242
95TBK10.59157345
96FLT30.58264211
97RAF10.57990443
98JAK10.57129526
99CAMK1D0.57121552
100CHEK10.56673594
101CAMK1G0.54748192
102LMTK20.54360808
103MST1R0.54339509
104CDC42BPA0.54306106
105RET0.54252408
106MAP2K20.53282642
107MAP3K80.53157330
108CSNK1G10.52508186
109STK40.49792128
110BCR0.49223416
111INSRR0.48710637
112BMX0.48113576
113FGFR10.48030099
114CDK70.47445220
115DYRK1B0.46512052
116KSR10.46365564
117GSK3A0.46266054
118CDK120.45510364
119BMPR1B0.45354402
120MAPK40.45083689
121CDK80.44387312
122PDK20.43827584
123MAPK150.43702629
124AURKA0.43487372
125TYRO30.42648762
126BLK0.42346916
127PIM10.41200571
128MARK20.40622119
129IRAK10.39963396
130AKT30.39503465
131AKT20.39191672
132EIF2AK30.38842708
133CHEK20.38813229
134MAP3K70.38638025
135NEK60.38618140
136IKBKB0.38137544
137AURKB0.38090888
138MAPKAPK20.37296575
139CDK20.37132954
140JAK30.37119403
141LRRK20.37019827
142BRSK10.36736136
143PLK30.35691172
144ABL10.34727704
145MAP3K20.32017576
146MAPK10.31934618
147RPS6KA10.30974131
148CDK140.30017120
149RPS6KA20.28716297

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.01158993
2Nitrogen metabolism_Homo sapiens_hsa009103.82886416
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18137851
4Complement and coagulation cascades_Homo sapiens_hsa046102.65641091
5Arginine biosynthesis_Homo sapiens_hsa002202.62702512
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53597819
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52826800
8Fatty acid degradation_Homo sapiens_hsa000712.47736946
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45928812
10Caffeine metabolism_Homo sapiens_hsa002322.41425605
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.40298094
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.35075894
13Vitamin B6 metabolism_Homo sapiens_hsa007502.33438093
14Tryptophan metabolism_Homo sapiens_hsa003802.28564515
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04980658
16Bladder cancer_Homo sapiens_hsa052192.04600027
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98371857
18Thyroid cancer_Homo sapiens_hsa052161.98137511
19PPAR signaling pathway_Homo sapiens_hsa033201.97085023
20Butanoate metabolism_Homo sapiens_hsa006501.93433117
21Staphylococcus aureus infection_Homo sapiens_hsa051501.84646769
22Peroxisome_Homo sapiens_hsa041461.84228396
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.82261006
24ECM-receptor interaction_Homo sapiens_hsa045121.78596974
25Fatty acid metabolism_Homo sapiens_hsa012121.76261602
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73246736
27Propanoate metabolism_Homo sapiens_hsa006401.69648294
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68680052
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.66517147
30Chemical carcinogenesis_Homo sapiens_hsa052041.64170772
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.61350276
32Non-small cell lung cancer_Homo sapiens_hsa052231.59928622
33Retinol metabolism_Homo sapiens_hsa008301.57486246
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56436523
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52175298
36beta-Alanine metabolism_Homo sapiens_hsa004101.49658770
37Focal adhesion_Homo sapiens_hsa045101.48268970
38Histidine metabolism_Homo sapiens_hsa003401.47793336
39Adherens junction_Homo sapiens_hsa045201.46799916
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45675969
41Vitamin digestion and absorption_Homo sapiens_hsa049771.44314044
42Selenocompound metabolism_Homo sapiens_hsa004501.43515947
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39017809
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38613335
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37757683
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36335631
47Lysine degradation_Homo sapiens_hsa003101.35456552
48Proteoglycans in cancer_Homo sapiens_hsa052051.34634820
49Folate biosynthesis_Homo sapiens_hsa007901.32717595
50Notch signaling pathway_Homo sapiens_hsa043301.31209515
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30081742
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.28180787
53Hepatitis B_Homo sapiens_hsa051611.28175691
54Renal cell carcinoma_Homo sapiens_hsa052111.27644578
55Shigellosis_Homo sapiens_hsa051311.24351693
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23723750
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.23195756
58Bile secretion_Homo sapiens_hsa049761.22777297
59ErbB signaling pathway_Homo sapiens_hsa040121.21137454
60mRNA surveillance pathway_Homo sapiens_hsa030151.20035097
61Apoptosis_Homo sapiens_hsa042101.18717657
62VEGF signaling pathway_Homo sapiens_hsa043701.17964679
63Steroid biosynthesis_Homo sapiens_hsa001001.11320069
64Sulfur relay system_Homo sapiens_hsa041221.09677018
65Pyruvate metabolism_Homo sapiens_hsa006201.09188068
66Spliceosome_Homo sapiens_hsa030401.08740234
67RNA transport_Homo sapiens_hsa030131.07222391
68Viral carcinogenesis_Homo sapiens_hsa052031.05284724
69B cell receptor signaling pathway_Homo sapiens_hsa046621.05248728
70Glioma_Homo sapiens_hsa052141.04874373
71mTOR signaling pathway_Homo sapiens_hsa041501.03878376
72Sulfur metabolism_Homo sapiens_hsa009201.03497996
73Biosynthesis of amino acids_Homo sapiens_hsa012301.03210214
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02232884
75Fat digestion and absorption_Homo sapiens_hsa049751.01905788
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01011951
77Starch and sucrose metabolism_Homo sapiens_hsa005000.99316728
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.98221943
79Other glycan degradation_Homo sapiens_hsa005110.98038149
80Phenylalanine metabolism_Homo sapiens_hsa003600.97087342
81Influenza A_Homo sapiens_hsa051640.96979565
82Colorectal cancer_Homo sapiens_hsa052100.96285520
83Insulin signaling pathway_Homo sapiens_hsa049100.93295967
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91355196
85Tyrosine metabolism_Homo sapiens_hsa003500.91351238
86HTLV-I infection_Homo sapiens_hsa051660.89588872
87ABC transporters_Homo sapiens_hsa020100.88032344
88Hippo signaling pathway_Homo sapiens_hsa043900.87205312
89Carbon metabolism_Homo sapiens_hsa012000.86846758
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86578779
91Salmonella infection_Homo sapiens_hsa051320.86553995
92Measles_Homo sapiens_hsa051620.86409611
93Pathways in cancer_Homo sapiens_hsa052000.85749102
94Melanoma_Homo sapiens_hsa052180.85432505
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84295671
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84193454
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.83198038
98DNA replication_Homo sapiens_hsa030300.82149359
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81899636
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80495649
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78969090
102Base excision repair_Homo sapiens_hsa034100.78563724
103Fatty acid biosynthesis_Homo sapiens_hsa000610.77990756
104Choline metabolism in cancer_Homo sapiens_hsa052310.77094373
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.76238277
106Pentose phosphate pathway_Homo sapiens_hsa000300.75865188
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75819870
108Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75460163
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.74475452
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74301487
111N-Glycan biosynthesis_Homo sapiens_hsa005100.73433880
112Fatty acid elongation_Homo sapiens_hsa000620.70348836
113One carbon pool by folate_Homo sapiens_hsa006700.69598516
114HIF-1 signaling pathway_Homo sapiens_hsa040660.68713718
115Arginine and proline metabolism_Homo sapiens_hsa003300.68339360
116Epstein-Barr virus infection_Homo sapiens_hsa051690.67422906
117Glycerolipid metabolism_Homo sapiens_hsa005610.67259684
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67070780
119Non-homologous end-joining_Homo sapiens_hsa034500.64458928
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.63990251
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63549256
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.63325176
123T cell receptor signaling pathway_Homo sapiens_hsa046600.62097443
124Inositol phosphate metabolism_Homo sapiens_hsa005620.61913568
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.61344878
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58840731
127Endocytosis_Homo sapiens_hsa041440.58109060
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58107516
129Malaria_Homo sapiens_hsa051440.57485192
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.57051064
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56790470
132Sphingolipid metabolism_Homo sapiens_hsa006000.55939967
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54813871
134Insulin resistance_Homo sapiens_hsa049310.53364665
135Glutathione metabolism_Homo sapiens_hsa004800.52369196
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49125519
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.46551597
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.41097475
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32898090
140Dorso-ventral axis formation_Homo sapiens_hsa043200.30851236
141Small cell lung cancer_Homo sapiens_hsa052220.29797128
142AMPK signaling pathway_Homo sapiens_hsa041520.28285607
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28172241
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26476105
145Metabolic pathways_Homo sapiens_hsa011000.25280974
146Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25197715
147p53 signaling pathway_Homo sapiens_hsa041150.23532182
148Legionellosis_Homo sapiens_hsa051340.22787989
149MicroRNAs in cancer_Homo sapiens_hsa052060.21960401
150Cell cycle_Homo sapiens_hsa041100.20606768
151Acute myeloid leukemia_Homo sapiens_hsa052210.18969267
152Chronic myeloid leukemia_Homo sapiens_hsa052200.17707252
153FoxO signaling pathway_Homo sapiens_hsa040680.17062767
154Pancreatic cancer_Homo sapiens_hsa052120.16984819
155Linoleic acid metabolism_Homo sapiens_hsa005910.15925375
156Renin-angiotensin system_Homo sapiens_hsa046140.15373545
157Glucagon signaling pathway_Homo sapiens_hsa049220.14775768
158Prostate cancer_Homo sapiens_hsa052150.14086974
159NF-kappa B signaling pathway_Homo sapiens_hsa040640.13200996
160Prolactin signaling pathway_Homo sapiens_hsa049170.12886301
161Toxoplasmosis_Homo sapiens_hsa051450.11547772
162Herpes simplex infection_Homo sapiens_hsa051680.10965029
163Prion diseases_Homo sapiens_hsa050200.10608057
164TNF signaling pathway_Homo sapiens_hsa046680.10290760
165Basal cell carcinoma_Homo sapiens_hsa052170.09222398
166TGF-beta signaling pathway_Homo sapiens_hsa043500.08946982
167Endometrial cancer_Homo sapiens_hsa052130.08867685
168Hepatitis C_Homo sapiens_hsa051600.08676625
169Amoebiasis_Homo sapiens_hsa051460.08562497
170Longevity regulating pathway - mammal_Homo sapiens_hsa042110.08256266
171NOD-like receptor signaling pathway_Homo sapiens_hsa046210.08252278

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