AMN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.03519327
2urate metabolic process (GO:0046415)8.74373676
3drug transport (GO:0015893)8.09356549
4aminoglycoside antibiotic metabolic process (GO:0030647)8.07251080
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.90780207
6regulation of guanylate cyclase activity (GO:0031282)7.55755120
7organic cation transport (GO:0015695)7.51157334
8lysine catabolic process (GO:0006554)7.39138967
9lysine metabolic process (GO:0006553)7.39138967
10drug catabolic process (GO:0042737)7.18762598
11phosphate ion transport (GO:0006817)6.92555534
12vitamin D metabolic process (GO:0042359)6.81529224
13epoxygenase P450 pathway (GO:0019373)6.56122444
14cysteine metabolic process (GO:0006534)6.26534262
15modified amino acid transport (GO:0072337)6.23206529
16fat-soluble vitamin biosynthetic process (GO:0042362)6.22826815
17exogenous drug catabolic process (GO:0042738)6.13598028
18glyoxylate metabolic process (GO:0046487)5.85030851
19phosphate ion transmembrane transport (GO:0035435)5.78288028
20nonribosomal peptide biosynthetic process (GO:0019184)5.77549712
21quaternary ammonium group transport (GO:0015697)5.71251345
22renal absorption (GO:0070293)5.49688323
23positive regulation of guanylate cyclase activity (GO:0031284)5.48139874
24response to mercury ion (GO:0046689)5.42472249
25glutathione biosynthetic process (GO:0006750)5.40114240
26lipoprotein transport (GO:0042953)5.38723160
27aspartate family amino acid catabolic process (GO:0009068)5.28189740
28endocrine process (GO:0050886)5.21047884
29regulation of systemic arterial blood pressure by hormone (GO:0001990)5.21047884
30regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.21047884
31* excretion (GO:0007588)5.13752474
32very-low-density lipoprotein particle assembly (GO:0034379)5.09296361
33diacylglycerol metabolic process (GO:0046339)5.00588210
34hormone catabolic process (GO:0042447)4.95078058
35serine family amino acid catabolic process (GO:0009071)4.88668444
36trivalent inorganic anion homeostasis (GO:0072506)4.87307114
37phosphate ion homeostasis (GO:0055062)4.87307114
38serine family amino acid metabolic process (GO:0009069)4.82288932
39proline metabolic process (GO:0006560)4.80282283
40tricarboxylic acid metabolic process (GO:0072350)4.75749584
41regulation of systemic arterial blood pressure (GO:0003073)4.72001033
42regulation of cellular extravasation (GO:0002691)4.70440989
43plasma lipoprotein particle assembly (GO:0034377)4.68238028
44short-chain fatty acid metabolic process (GO:0046459)4.67738160
45NADH metabolic process (GO:0006734)4.64959621
46regulation of cGMP biosynthetic process (GO:0030826)4.63158702
47renal system process involved in regulation of blood volume (GO:0001977)4.58907680
48homocysteine metabolic process (GO:0050667)4.56332852
49fructose metabolic process (GO:0006000)4.55344628
50receptor guanylyl cyclase signaling pathway (GO:0007168)4.54969478
51polyol transport (GO:0015791)4.42359816
52regulation of triglyceride catabolic process (GO:0010896)4.42306105
53positive regulation of pseudopodium assembly (GO:0031274)4.33671941
54peptide biosynthetic process (GO:0043043)4.33652144
55urea cycle (GO:0000050)4.31947514
56* vitamin transport (GO:0051180)4.28615258
57protein-lipid complex assembly (GO:0065005)4.28053165
58L-phenylalanine metabolic process (GO:0006558)4.25149248
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.25149248
60oligosaccharide catabolic process (GO:0009313)4.24633165
61amino-acid betaine transport (GO:0015838)4.24569947
62carnitine transport (GO:0015879)4.24569947
63peptide catabolic process (GO:0043171)4.22145406
64cellular modified amino acid catabolic process (GO:0042219)4.18462537
65urea metabolic process (GO:0019627)4.17960770
66sulfur compound transport (GO:0072348)4.17071607
67intestinal absorption (GO:0050892)4.15977627
68antibacterial humoral response (GO:0019731)4.15699873
69serine family amino acid biosynthetic process (GO:0009070)4.14959288
70adhesion of symbiont to host cell (GO:0044650)4.12863769
71virion attachment to host cell (GO:0019062)4.12863769
72antimicrobial humoral response (GO:0019730)4.08291613
73flavonoid metabolic process (GO:0009812)4.04309007
74vitamin transmembrane transport (GO:0035461)4.03497006
75bile acid and bile salt transport (GO:0015721)4.02312681
76peptide hormone processing (GO:0016486)4.01394013
77metanephric tubule development (GO:0072170)3.97049351
78metanephric nephron tubule development (GO:0072234)3.97049351
79regulation of cholesterol esterification (GO:0010872)3.96057338
80amino-acid betaine metabolic process (GO:0006577)3.93154345
81nitrogen cycle metabolic process (GO:0071941)3.91598526
822-oxoglutarate metabolic process (GO:0006103)3.90660744
83tryptophan catabolic process (GO:0006569)3.90498602
84indole-containing compound catabolic process (GO:0042436)3.90498602
85indolalkylamine catabolic process (GO:0046218)3.90498602
86cellular glucuronidation (GO:0052695)3.90470735
87phospholipid efflux (GO:0033700)3.90189252
88glucuronate metabolic process (GO:0019585)3.89590175
89uronic acid metabolic process (GO:0006063)3.89590175
90regulation of pseudopodium assembly (GO:0031272)3.87809658
91glutamate metabolic process (GO:0006536)3.85473815
92maintenance of gastrointestinal epithelium (GO:0030277)3.84760238
93regulation of cGMP metabolic process (GO:0030823)3.83786104
94glycoside metabolic process (GO:0016137)3.82683668
95aromatic amino acid family catabolic process (GO:0009074)3.81729669
96branched-chain amino acid metabolic process (GO:0009081)3.81026431
97response to phenylpropanoid (GO:0080184)3.78632249
98regulation of vitamin metabolic process (GO:0030656)3.76177410
99fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.74430072
100glutathione derivative metabolic process (GO:1901685)3.70981200
101glutathione derivative biosynthetic process (GO:1901687)3.70981200
102alditol metabolic process (GO:0019400)3.69100769
103erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.68388431
104L-phenylalanine catabolic process (GO:0006559)3.68388431
105toxin transport (GO:1901998)3.68308104
106positive regulation of respiratory burst (GO:0060267)3.67039178
107glutathione metabolic process (GO:0006749)3.65279910
108cGMP-mediated signaling (GO:0019934)3.64790848
109alkaloid metabolic process (GO:0009820)3.63035839
110adhesion of symbiont to host (GO:0044406)3.62751650
111cellular response to nitric oxide (GO:0071732)3.62284712
112positive regulation of lipoprotein lipase activity (GO:0051006)3.61770691
113positive regulation of triglyceride lipase activity (GO:0061365)3.61770691
114metanephric nephron epithelium development (GO:0072243)3.61332344
115tryptophan metabolic process (GO:0006568)3.60753369
116folic acid metabolic process (GO:0046655)3.60404936
117cellular ketone body metabolic process (GO:0046950)3.59505964
118digestion (GO:0007586)3.59304798
119regulation of bile acid biosynthetic process (GO:0070857)3.58958131
120angiotensin maturation (GO:0002003)3.56055811
121fatty acid beta-oxidation (GO:0006635)3.56020793
122renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.53801835
123glycolipid catabolic process (GO:0019377)3.52858546
124glycosphingolipid catabolic process (GO:0046479)3.51345209
125drug metabolic process (GO:0017144)3.50720305
126calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.50693311
127tricarboxylic acid cycle (GO:0006099)3.49818332
128ethanol oxidation (GO:0006069)3.48176897
129mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.46211368
130phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.44236481
131carnitine metabolic process (GO:0009437)3.42500518
132plasma lipoprotein particle organization (GO:0071827)3.37578234
133response to nitric oxide (GO:0071731)3.37336257
134positive regulation of lipid catabolic process (GO:0050996)3.37102781
135response to parathyroid hormone (GO:0071107)3.36774804
136fat-soluble vitamin metabolic process (GO:0006775)3.35820894
137transepithelial transport (GO:0070633)3.35541838
138triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.34760472
139glycerol metabolic process (GO:0006071)3.33901424
140acetyl-CoA metabolic process (GO:0006084)3.33817502
141positive regulation of glycoprotein biosynthetic process (GO:0010560)3.33676020
142fatty acid oxidation (GO:0019395)3.33259320
143protein-lipid complex remodeling (GO:0034368)3.31471093
144macromolecular complex remodeling (GO:0034367)3.31471093
145plasma lipoprotein particle remodeling (GO:0034369)3.31471093
146cellular amino acid catabolic process (GO:0009063)3.31246449
147nucleoside diphosphate biosynthetic process (GO:0009133)3.30659747
148actin filament depolymerization (GO:0030042)3.29817878
149glutamine family amino acid biosynthetic process (GO:0009084)3.28872890
150regulation of cholesterol homeostasis (GO:2000188)3.28857601
151metanephric epithelium development (GO:0072207)3.26854527
152antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.25825813
153lipid oxidation (GO:0034440)3.25019758
154protein-lipid complex subunit organization (GO:0071825)3.23577994
155valine metabolic process (GO:0006573)3.23507916
156high-density lipoprotein particle remodeling (GO:0034375)3.22837615
157sulfur amino acid catabolic process (GO:0000098)3.21555882
158arginine metabolic process (GO:0006525)3.21219186
159sodium ion transport (GO:0006814)3.20469924
160positive regulation of cGMP biosynthetic process (GO:0030828)3.20027362
161dicarboxylic acid metabolic process (GO:0043648)3.19359074
162alpha-amino acid catabolic process (GO:1901606)3.19013526
163cellular response to reactive nitrogen species (GO:1902170)3.18076435
164antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.15702458
165kynurenine metabolic process (GO:0070189)3.14546096
166digestive system process (GO:0022600)3.14197431
167antigen processing and presentation of endogenous antigen (GO:0019883)3.12939496
168folic acid transport (GO:0015884)3.12710779
169vitamin biosynthetic process (GO:0009110)3.12176769
170leukotriene metabolic process (GO:0006691)3.11755895
171ATP synthesis coupled proton transport (GO:0015986)3.11536885
172energy coupled proton transport, down electrochemical gradient (GO:0015985)3.11536885
173cytidine catabolic process (GO:0006216)3.10075763
174cytidine deamination (GO:0009972)3.10075763
175positive regulation of Cdc42 GTPase activity (GO:0043089)3.08491116
176glomerular filtration (GO:0003094)3.06105648
177positive regulation of glycoprotein metabolic process (GO:1903020)3.05953630
178drinking behavior (GO:0042756)3.04489443
179vitamin A metabolic process (GO:0006776)3.03201678
180transcytosis (GO:0045056)3.01191386
181bile acid metabolic process (GO:0008206)3.00486876
182sexual reproduction (GO:0019953)2.98762536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.58745387
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.25191652
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.15286602
4HNF4A_19761587_ChIP-ChIP_CACO-2_Human4.01670571
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.72166177
6CDX2_20551321_ChIP-Seq_CACO-2_Human3.44854959
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.43765175
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.23200885
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.15205989
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.12748121
11AR_21909140_ChIP-Seq_LNCAP_Human2.99348684
12NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.84803625
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.84019598
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.77956323
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.69506429
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.54706784
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.44022911
18GATA4_25053715_ChIP-Seq_YYC3_Human2.25550114
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21881011
20SOX2_27498859_Chip-Seq_STOMACH_Mouse2.15000416
21STAT3_1855785_ChIP-Seq_MESCs_Mouse2.04070837
22GATA6_25053715_ChIP-Seq_YYC3_Human2.03506575
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97043607
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94420101
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.91870095
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.88083493
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.80128253
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.78382707
29PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.76623963
30GATA1_22025678_ChIP-Seq_K562_Human1.74835399
31RACK7_27058665_Chip-Seq_MCF-7_Human1.73081963
32CLOCK_20551151_ChIP-Seq_293T_Human1.71459919
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70198000
34* HNF4A_19822575_ChIP-Seq_HepG2_Human1.60211680
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.59226890
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59183298
37* LXR_22292898_ChIP-Seq_THP-1_Human1.58695812
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51143813
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48157682
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47393701
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.47272791
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46172904
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45373193
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41283681
45VDR_22108803_ChIP-Seq_LS180_Human1.38326194
46ZNF263_19887448_ChIP-Seq_K562_Human1.38083393
47* SA1_27219007_Chip-Seq_Bcells_Human1.36453296
48* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.36254395
49* BCL6_27268052_Chip-Seq_Bcells_Human1.35832029
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.34719442
51* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31485524
52SOX2_18692474_ChIP-Seq_MEFs_Mouse1.31234645
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30878622
54* TET1_21451524_ChIP-Seq_MESCs_Mouse1.30672927
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28976681
56ATF3_27146783_Chip-Seq_COLON_Human1.28339794
57TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.24368941
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24016534
59P68_20966046_ChIP-Seq_HELA_Human1.23441366
60NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22382037
61BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.21922119
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21797053
63VDR_21846776_ChIP-Seq_THP-1_Human1.21517003
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20683803
65* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.18586829
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18263297
67SOX2_20726797_ChIP-Seq_SW620_Human1.17931831
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17369576
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17368860
70AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17202183
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16882414
72OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16757489
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15835417
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15411252
75VDR_24763502_ChIP-Seq_THP-1_Human1.14437190
76KLF5_25053715_ChIP-Seq_YYC3_Human1.13311319
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13229701
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12190808
79CTCF_27219007_Chip-Seq_Bcells_Human1.12081862
80EGR1_19032775_ChIP-ChIP_M12_Human1.07885059
81CREB1_26743006_Chip-Seq_LNCaP_Human1.07372487
82GATA1_19941826_ChIP-Seq_K562_Human1.06664857
83RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04985694
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04921488
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04753330
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.04354987
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.03779084
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03456594
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01548770
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.01493363
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00300565
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00112559
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99616396
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99152035
95* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98829020
96TAF2_19829295_ChIP-Seq_ESCs_Human0.98679664
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98521359
98GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97070118
99TCF4_18268006_ChIP-ChIP_LS174T_Human0.96896203
100E2F1_20622854_ChIP-Seq_HELA_Human0.96152040
101FOXA2_19822575_ChIP-Seq_HepG2_Human0.95849365
102FOXA1_25552417_ChIP-Seq_VCAP_Human0.95837362
103GATA2_19941826_ChIP-Seq_K562_Human0.95732882
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94978616
105NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94351755
106YY1_22570637_ChIP-Seq_MALME-3M_Human0.93226262
107RUNX1_27514584_Chip-Seq_MCF-7_Human0.92611170
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92506726
109* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92070492
110GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92025752
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91613899
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91134628
113CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91092459
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90609280
115DROSHA_22980978_ChIP-Seq_HELA_Human0.90367276
116FOXO3_23340844_ChIP-Seq_DLD1_Human0.89522030
117* SOX2_21211035_ChIP-Seq_LN229_Human0.89487512
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88993902
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88944320
120RARA_24833708_ChIP-Seq_LIVER_Mouse0.88622301
121ETS1_21867929_ChIP-Seq_TH2_Mouse0.88483516
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88050748
123SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87725174
124MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86235697
125* BCOR_27268052_Chip-Seq_Bcells_Human0.85264537
126TP63_22573176_ChIP-Seq_HFKS_Human0.85025283
127SA1_27219007_Chip-Seq_ERYTHROID_Human0.84657748
128SMC4_20622854_ChIP-Seq_HELA_Human0.84250755
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84101387
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83734953
131POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.83587409
132RAC3_21632823_ChIP-Seq_H3396_Human0.82980294
133P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.82775095
134NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82718773
135PHF8_20622854_ChIP-Seq_HELA_Human0.82365619
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82312898
137MYC_19915707_ChIP-ChIP_AK7_Human0.80812246
138CTCF_20526341_ChIP-Seq_ESCs_Human0.78563458
139GATA3_21867929_ChIP-Seq_CD8_Mouse0.77129894
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76682935
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.76585503
142EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76289290
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75972607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.25318467
2MP0004019_abnormal_vitamin_homeostasis5.40029974
3MP0004043_abnormal_pH_regulation5.11781703
4MP0002139_abnormal_hepatobiliary_system4.67079329
5MP0005332_abnormal_amino_acid4.28279509
6MP0009379_abnormal_foot_pigmentation4.00628702
7MP0009643_abnormal_urine_homeostasis3.49451119
8MP0005377_hearing/vestibular/ear_phenot3.39158469
9MP0003878_abnormal_ear_physiology3.39158469
10MP0001765_abnormal_ion_homeostasis3.24644028
11MP0004264_abnormal_extraembryonic_tissu2.97021936
12MP0002138_abnormal_hepatobiliary_system2.93129461
13MP0008875_abnormal_xenobiotic_pharmacok2.92207910
14MP0003195_calcinosis2.70815762
15MP0005636_abnormal_mineral_homeostasis2.69233938
16MP0001756_abnormal_urination2.57417456
17MP0002136_abnormal_kidney_physiology2.54257175
18MP0005085_abnormal_gallbladder_physiolo2.50564637
19MP0001666_abnormal_nutrient_absorption2.49597605
20MP0005365_abnormal_bile_salt2.43918806
21MP0003252_abnormal_bile_duct2.26032286
22MP0005409_darkened_coat_color2.19698061
23MP0005084_abnormal_gallbladder_morpholo2.08777918
24MP0001958_emphysema1.98853280
25MP0010234_abnormal_vibrissa_follicle1.92743521
26MP0000538_abnormal_urinary_bladder1.83534340
27MP0010352_gastrointestinal_tract_polyps1.79835386
28MP0003868_abnormal_feces_composition1.67479457
29MP0005451_abnormal_body_composition1.54150950
30MP0005058_abnormal_lysosome_morphology1.35639727
31MP0010329_abnormal_lipoprotein_level1.34655515
32MP0002876_abnormal_thyroid_physiology1.31815130
33MP0001188_hyperpigmentation1.28369807
34MP0009840_abnormal_foam_cell1.27926334
35MP0005584_abnormal_enzyme/coenzyme_acti1.26980221
36MP0003191_abnormal_cellular_cholesterol1.25542480
37MP0003806_abnormal_nucleotide_metabolis1.23864644
38MP0006036_abnormal_mitochondrial_physio1.19373561
39MP0004885_abnormal_endolymph1.18467189
40MP0003186_abnormal_redox_activity1.16672526
41MP0004782_abnormal_surfactant_physiolog1.15530920
42MP0002089_abnormal_postnatal_growth/wei1.13659408
43MP0005319_abnormal_enzyme/_coenzyme1.11074255
44MP0001764_abnormal_homeostasis1.06355605
45MP0003879_abnormal_hair_cell1.05758716
46MP0002796_impaired_skin_barrier1.05389707
47MP0000537_abnormal_urethra_morphology1.01822479
48MP0008961_abnormal_basal_metabolism1.01736527
49MP0004147_increased_porphyrin_level0.97906933
50MP0005448_abnormal_energy_balance0.95394178
51MP0002971_abnormal_brown_adipose0.94637206
52MP0000230_abnormal_systemic_arterial0.93127363
53MP0002822_catalepsy0.92630524
54MP0001845_abnormal_inflammatory_respons0.92475475
55MP0004272_abnormal_basement_membrane0.91993054
56MP0003315_abnormal_perineum_morphology0.91791586
57MP0005666_abnormal_adipose_tissue0.91266992
58MP0003283_abnormal_digestive_organ0.90996284
59MP0002135_abnormal_kidney_morphology0.89099806
60MP0003123_paternal_imprinting0.88858127
61MP0002118_abnormal_lipid_homeostasis0.88259489
62MP0003718_maternal_effect0.87152669
63MP0003303_peritoneal_inflammation0.86448500
64MP0003436_decreased_susceptibility_to0.85956108
65MP0009785_altered_susceptibility_to0.83117111
66MP0004270_analgesia0.80570177
67MP0000566_synostosis0.80564700
68MP0001663_abnormal_digestive_system0.80497220
69MP0003941_abnormal_skin_development0.78553192
70MP0003638_abnormal_response/metabolism_0.78507573
71MP0005025_abnormal_response_to0.76241206
72MP0009115_abnormal_fat_cell0.75966880
73MP0001664_abnormal_digestion0.75738261
74MP0000462_abnormal_digestive_system0.75695349
75MP0008469_abnormal_protein_level0.75634318
76MP0003724_increased_susceptibility_to0.75077854
77MP0005501_abnormal_skin_physiology0.74651575
78MP0005535_abnormal_body_temperature0.74612706
79MP0009642_abnormal_blood_homeostasis0.72190106
80MP0001501_abnormal_sleep_pattern0.71599970
81MP0005381_digestive/alimentary_phenotyp0.71164527
82MP0001485_abnormal_pinna_reflex0.70729489
83MP0003300_gastrointestinal_ulcer0.69596016
84MP0001835_abnormal_antigen_presentation0.68819632
85MP0006035_abnormal_mitochondrial_morpho0.68302225
86MP0002166_altered_tumor_susceptibility0.67898572
87MP0002896_abnormal_bone_mineralization0.67324266
88MP0000609_abnormal_liver_physiology0.67214534
89MP0005387_immune_system_phenotype0.67092872
90MP0001790_abnormal_immune_system0.67092872
91MP0005395_other_phenotype0.66973660
92MP0000604_amyloidosis0.66227303
93MP0000465_gastrointestinal_hemorrhage0.65444222
94MP0003329_amyloid_beta_deposits0.64906724
95MP0009333_abnormal_splenocyte_physiolog0.64402899
96MP0000477_abnormal_intestine_morphology0.64312316
97MP0000249_abnormal_blood_vessel0.63600679
98MP0008872_abnormal_physiological_respon0.62237695
99MP0003646_muscle_fatigue0.60945045
100MP0004947_skin_inflammation0.60636694
101MP0002098_abnormal_vibrissa_morphology0.58526507
102MP0002928_abnormal_bile_duct0.56455497
103MP0003866_abnormal_defecation0.55876258
104MP0000490_abnormal_crypts_of0.55308006
105MP0009764_decreased_sensitivity_to0.52856144
106MP0005334_abnormal_fat_pad0.52731976
107MP0006082_CNS_inflammation0.52033390
108MP0000678_abnormal_parathyroid_gland0.51728314
109MP0002168_other_aberrant_phenotype0.51463745
110MP0002148_abnormal_hypersensitivity_rea0.50483792
111MP0003221_abnormal_cardiomyocyte_apopto0.49112345
112MP0000013_abnormal_adipose_tissue0.47767285
113MP0008260_abnormal_autophagy0.46918759
114MP0004858_abnormal_nervous_system0.46514845
115MP0005167_abnormal_blood-brain_barrier0.46258466
116MP0003953_abnormal_hormone_level0.45562004
117MP0004484_altered_response_of0.45133755
118MP0009672_abnormal_birth_weight0.44686808
119MP0000598_abnormal_liver_morphology0.42347864
120MP0005165_increased_susceptibility_to0.41211151
121MP0002078_abnormal_glucose_homeostasis0.41153200
122MP0010155_abnormal_intestine_physiology0.40688570
123MP0005670_abnormal_white_adipose0.40507437
124MP0000747_muscle_weakness0.39016033
125MP0002069_abnormal_eating/drinking_beha0.35494188
126MP0003183_abnormal_peptide_metabolism0.34217627
127MP0001661_extended_life_span0.34155554
128MP0003119_abnormal_digestive_system0.34016296
129MP0001873_stomach_inflammation0.33963802
130MP0003705_abnormal_hypodermis_morpholog0.33573040
131MP0001727_abnormal_embryo_implantation0.33042798
132MP0001963_abnormal_hearing_physiology0.32851176
133MP0001849_ear_inflammation0.31462323
134MP0005166_decreased_susceptibility_to0.31339057
135MP0008004_abnormal_stomach_pH0.30179772

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)6.59405709
2Metabolic alkalosis (HP:0200114)6.54649910
3Gout (HP:0001997)6.44747983
4Hypokalemic alkalosis (HP:0001949)6.14187207
5Hyperactive renin-angiotensin system (HP:0000841)6.08448026
6Hypomagnesemia (HP:0002917)5.98881035
7Polyuria (HP:0000103)5.89576414
8Abnormal urine output (HP:0012590)5.75157659
9Proximal tubulopathy (HP:0000114)5.69517543
10Abnormality of glutamine family amino acid metabolism (HP:0010902)5.68910429
11Abnormality of chloride homeostasis (HP:0011422)5.58531356
12Abnormality of renal excretion (HP:0011036)5.45194760
13Abnormality of magnesium homeostasis (HP:0004921)5.40241500
14Hyperglycinuria (HP:0003108)5.35311210
15Hyperuricemia (HP:0002149)4.89848588
16Increased purine levels (HP:0004368)4.89848588
17Chronic diarrhea (HP:0002028)4.85187776
18Systemic lupus erythematosus (HP:0002725)4.80759003
19Hypobetalipoproteinemia (HP:0003563)4.79123606
20Polydipsia (HP:0001959)4.62026578
21Abnormal drinking behavior (HP:0030082)4.62026578
22Abnormality of purine metabolism (HP:0004352)4.37293942
23Abnormality of glycine metabolism (HP:0010895)4.32813111
24Abnormality of serine family amino acid metabolism (HP:0010894)4.32813111
25Alkalosis (HP:0001948)4.25745449
26Abnormality of urine glucose concentration (HP:0011016)4.16739296
27Glycosuria (HP:0003076)4.16739296
28Hypercalciuria (HP:0002150)4.13007698
29Abnormality of renin-angiotensin system (HP:0000847)4.11989705
30Renal salt wasting (HP:0000127)4.10567566
31Tetany (HP:0001281)4.08377021
32Fat malabsorption (HP:0002630)4.07012006
33Hyperaldosteronism (HP:0000859)4.03776462
34Hyperphosphaturia (HP:0003109)3.95832246
35Decreased circulating renin level (HP:0003351)3.76574464
36Generalized aminoaciduria (HP:0002909)3.74633510
37Abnormality of monocarboxylic acid metabolism (HP:0010996)3.68710815
38Abnormality of proline metabolism (HP:0010907)3.63892224
39Hydroxyprolinuria (HP:0003080)3.63892224
40Abnormal urine phosphate concentration (HP:0012599)3.59293895
41Delayed epiphyseal ossification (HP:0002663)3.53083444
42Acanthocytosis (HP:0001927)3.41680106
43Abnormality of nucleobase metabolism (HP:0010932)3.35864245
44Ketoacidosis (HP:0001993)3.34688977
45Malnutrition (HP:0004395)3.33585424
46Hemorrhage of the eye (HP:0011885)3.25280376
47Nephrolithiasis (HP:0000787)3.20724273
48Congenital sensorineural hearing impairment (HP:0008527)3.19815983
49Hypokalemia (HP:0002900)3.13514102
50Abnormality of aspartate family amino acid metabolism (HP:0010899)3.11998631
51Abdominal distention (HP:0003270)3.11846864
52Pigmentary retinal degeneration (HP:0001146)3.10597804
53Renal tubular acidosis (HP:0001947)3.09692364
54Hyperglycinemia (HP:0002154)3.08657936
55Ketosis (HP:0001946)2.86182656
56Widely patent fontanelles and sutures (HP:0004492)2.84853183
57Hypophosphatemia (HP:0002148)2.77811093
58Nephrocalcinosis (HP:0000121)2.72273983
59Complement deficiency (HP:0004431)2.71859036
60Eczematoid dermatitis (HP:0000976)2.69966691
61Abnormality of complement system (HP:0005339)2.68976947
62Hyperparathyroidism (HP:0000843)2.68935349
63Steatorrhea (HP:0002570)2.67423082
64Villous atrophy (HP:0011473)2.65337795
65Abnormality of small intestinal villus morphology (HP:0011472)2.65337795
66Glomerulonephritis (HP:0000099)2.65332438
67Dehydration (HP:0001944)2.63661430
68Posterior subcapsular cataract (HP:0007787)2.58452911
69Abnormality of fatty-acid metabolism (HP:0004359)2.56948157
70Hyperammonemia (HP:0001987)2.56030159
71Hypolipoproteinemia (HP:0010981)2.52690407
72Abnormality of potassium homeostasis (HP:0011042)2.50636268
73* Confusion (HP:0001289)2.48521908
74Vacuolated lymphocytes (HP:0001922)2.46051473
75Delayed CNS myelination (HP:0002188)2.45523579
76Rickets (HP:0002748)2.45289962
77Dicarboxylic aciduria (HP:0003215)2.43995782
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43995782
79Abnormality of sulfur amino acid metabolism (HP:0004339)2.42814675
80Focal segmental glomerulosclerosis (HP:0000097)2.40852198
81Ileus (HP:0002595)2.40560080
82Lethargy (HP:0001254)2.39359456
83Flat acetabular roof (HP:0003180)2.38657344
84* Abnormality of vitamin metabolism (HP:0100508)2.33405674
85Vascular calcification (HP:0004934)2.32943324
86Vomiting (HP:0002013)2.31072080
87Metabolic acidosis (HP:0001942)2.29659513
88Metaphyseal cupping (HP:0003021)2.26914778
89Nephritis (HP:0000123)2.26387387
90Abnormality of sodium homeostasis (HP:0010931)2.25691929
91Thin bony cortex (HP:0002753)2.20941229
92Hyponatremia (HP:0002902)2.20678115
93Abnormality of pyrimidine metabolism (HP:0004353)2.20142017
94Cerebral palsy (HP:0100021)2.19276996
95Hyperphosphatemia (HP:0002905)2.17904769
96Renal tubular dysfunction (HP:0000124)2.17780116
97Nausea (HP:0002018)2.16456026
98Growth hormone excess (HP:0000845)2.15923364
99Abnormality of renal resorption (HP:0011038)2.14690870
100Abnormal tarsal ossification (HP:0008369)2.13815179
101Epidermoid cyst (HP:0200040)2.12918571
102Pancreatitis (HP:0001733)2.12795988
103Methylmalonic aciduria (HP:0012120)2.10316029
104Subcapsular cataract (HP:0000523)2.06418328
105Potter facies (HP:0002009)2.06131154
106Facial shape deformation (HP:0011334)2.06131154
107Right ventricular cardiomyopathy (HP:0011663)2.05170163
108Protuberant abdomen (HP:0001538)2.04119413
109Enlarged kidneys (HP:0000105)2.02864285
110Cardiovascular calcification (HP:0011915)2.01999090
111Pili torti (HP:0003777)2.00883384
112Bicornuate uterus (HP:0000813)1.99772880
113Abnormal enzyme/coenzyme activity (HP:0012379)1.99512654
114Gingivitis (HP:0000230)1.98569583
115Adrenal overactivity (HP:0002717)1.96229505
116Gastrointestinal dysmotility (HP:0002579)1.96205227
117Abnormality of alkaline phosphatase activity (HP:0004379)1.96124747
118Abnormal glucose tolerance (HP:0001952)1.95414850
119Late onset (HP:0003584)1.94172678
120Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93711474
121Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.90391632
122Acute encephalopathy (HP:0006846)1.89681779
123* Abnormality of the vitamin B12 metabolism (HP:0004341)1.89538072
124Irritability (HP:0000737)1.87580131
125Hypoglycemic coma (HP:0001325)1.86742320
126Glomerulosclerosis (HP:0000096)1.84926044
127Metaphyseal irregularity (HP:0003025)1.83626170
128Xanthomatosis (HP:0000991)1.83561543
129Intrahepatic cholestasis (HP:0001406)1.82494654
130Abnormal hair laboratory examination (HP:0003328)1.82412137
131Abnormality of serum amino acid levels (HP:0003112)1.81270550
132Abnormality of the costochondral junction (HP:0000919)1.79320499
133Multiple lipomas (HP:0001012)1.78784687
134Wide cranial sutures (HP:0010537)1.78485846
135Petechiae (HP:0000967)1.78148575
136Pustule (HP:0200039)1.75906133
137Abnormality of carpal bone ossification (HP:0006257)1.75484335
138* Abnormality of vitamin B metabolism (HP:0004340)1.74962763
139Conjugated hyperbilirubinemia (HP:0002908)1.74724501
140Segmental peripheral demyelination/remyelination (HP:0003481)1.74640855
141Bilateral sensorineural hearing impairment (HP:0008619)1.71721428
142Tubular atrophy (HP:0000092)1.68545962
143Hypotension (HP:0002615)1.68387702
144Chondrocalcinosis (HP:0000934)1.64164188
145Enlarged epiphyses (HP:0010580)1.63772999
146Tubulointerstitial fibrosis (HP:0005576)1.63762487
147Sensorimotor neuropathy (HP:0007141)1.62268196

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.80902900
2WNK37.01006523
3ACVR1B6.64352536
4OXSR16.41721916
5ERN15.33419542
6STK393.58975474
7STK38L2.98961923
8NME12.78602453
9MST42.71718978
10BCKDK2.50168837
11PDK42.33107138
12PDK32.33107138
13NEK12.32967615
14GRK62.09597679
15MAP4K11.95041343
16PIK3CA1.73101467
17PDK21.61877492
18TYK21.58931172
19FRK1.58728753
20MST1R1.52739187
21DDR21.46363251
22STK381.40048799
23RIPK41.39384428
24SGK2231.38546322
25SGK4941.38546322
26MAP3K31.38346739
27PRPF4B1.34715364
28EPHA31.29465259
29MATK1.27927544
30TTK1.26779341
31MAP3K11.25708929
32EPHB11.22269095
33WNK11.20945033
34PRKCI1.20704946
35FGFR31.14482692
36MAP3K111.12015045
37PAK41.11767505
38TRIB31.10321300
39CDC42BPA1.07393802
40SMG11.04377877
41SCYL21.02553854
42NME20.94156301
43STK240.93157927
44ERBB20.91228488
45EPHA20.91104577
46LRRK20.91088344
47MAP2K20.85673796
48LMTK20.83812970
49TBK10.82097744
50NEK20.80297107
51SIK10.77225730
52BUB10.77164951
53STK100.76269176
54PRKG20.75968542
55MAP3K20.74881899
56PTK20.73811534
57IRAK30.68401815
58GSK3A0.67141402
59TAOK10.66630694
60KSR20.59337350
61TNIK0.58685112
62PTK60.57912938
63PAK30.57395893
64MAPK110.57068421
65MAP3K100.57007926
66TESK10.56511117
67IKBKE0.56507683
68NLK0.54784880
69PDPK10.54225325
70BRAF0.53889963
71ZAP700.53431995
72MAP3K80.53003513
73CSF1R0.51811023
74SGK20.51345868
75KSR10.51158009
76SGK30.49931570
77CSK0.49248781
78RIPK10.48881822
79AKT20.47472212
80FER0.46960316
81SRC0.46794852
82AKT30.46174665
83ICK0.46149448
84LIMK10.45256903
85PDGFRA0.45049607
86MAP3K90.44721236
87RET0.44607561
88STK110.43702773
89FGFR40.43332038
90MAP2K60.43146429
91BMX0.41808056
92FYN0.41760186
93CAMK2D0.41300697
94TESK20.40688170
95PRKAA10.40450630
96MAP3K140.40056730
97EPHB20.38146696
98SGK10.38001735
99ITK0.37031003
100ARAF0.36685804
101LATS10.36466055
102IRAK10.36020958
103PINK10.35781775
104JAK10.34502911
105MARK10.34042449
106MET0.33998906
107MINK10.33617375
108JAK20.33062785
109PRKCZ0.32436504
110IRAK40.32120279
111PDK10.31569734
112DYRK1B0.31044552
113LYN0.29939344
114PRKAA20.29869219
115EPHA40.29678024
116PRKCQ0.29498480
117BTK0.29182084
118JAK30.28423834
119EIF2AK10.28308349
120SYK0.28303821
121RPS6KA20.28207772
122ABL20.26852075
123MYLK0.26789741
124AURKA0.26687884
125GRK10.26108523
126MAP2K10.25609195
127MAP3K120.25387171
128KDR0.23798713
129ERBB40.23536559
130MAPKAPK20.22448614
131RPS6KC10.22239292
132RPS6KL10.22239292
133LCK0.22100958
134PRKCA0.21521623
135PAK10.21457333
136TIE10.21025830
137MARK30.20865183
138PIM10.20786934
139MAP2K30.19002752
140MAP2K40.18996354
141STK160.18258458
142MAP3K70.16583936
143DYRK30.16557853
144LATS20.15167789
145PRKACG0.14955161
146CAMK2G0.14830290
147PRKCD0.14411885
148CSNK1E0.14284780
149CSNK1A10.14203862
150PRKCG0.11318133
151PRKACA0.08966166

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.88474830
2Vitamin digestion and absorption_Homo sapiens_hsa049773.34978839
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.22409927
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18388719
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.10979497
6Butanoate metabolism_Homo sapiens_hsa006502.93802296
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.84980825
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.79958212
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.49194823
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47328647
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43979182
12Pyruvate metabolism_Homo sapiens_hsa006202.42054706
13Propanoate metabolism_Homo sapiens_hsa006402.35905119
14Caffeine metabolism_Homo sapiens_hsa002322.11728442
15Tryptophan metabolism_Homo sapiens_hsa003802.02683805
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01448090
17Fatty acid degradation_Homo sapiens_hsa000711.92757194
18Glutathione metabolism_Homo sapiens_hsa004801.92657066
19Mineral absorption_Homo sapiens_hsa049781.91785387
20Sulfur metabolism_Homo sapiens_hsa009201.91750174
21Peroxisome_Homo sapiens_hsa041461.86243065
22Bile secretion_Homo sapiens_hsa049761.84161519
23Carbon metabolism_Homo sapiens_hsa012001.82413536
24Fat digestion and absorption_Homo sapiens_hsa049751.81658495
25Collecting duct acid secretion_Homo sapiens_hsa049661.78811723
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76960517
27beta-Alanine metabolism_Homo sapiens_hsa004101.71165663
28Arginine and proline metabolism_Homo sapiens_hsa003301.68149750
29Protein digestion and absorption_Homo sapiens_hsa049741.61317787
30Renin-angiotensin system_Homo sapiens_hsa046141.55279676
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54975758
32Fructose and mannose metabolism_Homo sapiens_hsa000511.54219692
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51018120
34Folate biosynthesis_Homo sapiens_hsa007901.49320116
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48134550
36Arginine biosynthesis_Homo sapiens_hsa002201.40091230
37Oxidative phosphorylation_Homo sapiens_hsa001901.39074617
38Nitrogen metabolism_Homo sapiens_hsa009101.37040396
39Histidine metabolism_Homo sapiens_hsa003401.30917469
40Biosynthesis of amino acids_Homo sapiens_hsa012301.28750504
41Asthma_Homo sapiens_hsa053101.28732417
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28019436
43Fatty acid metabolism_Homo sapiens_hsa012121.15483501
44PPAR signaling pathway_Homo sapiens_hsa033201.13886162
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11028693
46Glycerolipid metabolism_Homo sapiens_hsa005611.10436234
47Other glycan degradation_Homo sapiens_hsa005111.10308640
48Selenocompound metabolism_Homo sapiens_hsa004501.09398195
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.07466623
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04709935
51Parkinsons disease_Homo sapiens_hsa050121.00447721
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99403538
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.97599781
54Staphylococcus aureus infection_Homo sapiens_hsa051500.96077969
55Allograft rejection_Homo sapiens_hsa053300.96028701
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94922612
57Lysine degradation_Homo sapiens_hsa003100.92455798
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.91795425
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91582127
60Galactose metabolism_Homo sapiens_hsa000520.90993159
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89830206
62Autoimmune thyroid disease_Homo sapiens_hsa053200.89411065
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86236973
64Graft-versus-host disease_Homo sapiens_hsa053320.85299133
65Ether lipid metabolism_Homo sapiens_hsa005650.83983795
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82281819
67Pentose phosphate pathway_Homo sapiens_hsa000300.80272373
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.74766643
69Thyroid hormone synthesis_Homo sapiens_hsa049180.69352307
70Phenylalanine metabolism_Homo sapiens_hsa003600.69097286
71Metabolic pathways_Homo sapiens_hsa011000.65886148
72Type I diabetes mellitus_Homo sapiens_hsa049400.65765872
73Arachidonic acid metabolism_Homo sapiens_hsa005900.58990581
74Huntingtons disease_Homo sapiens_hsa050160.57480968
75Alzheimers disease_Homo sapiens_hsa050100.56219402
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55611510
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.53428969
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52925715
79Vibrio cholerae infection_Homo sapiens_hsa051100.50457944
80Chemical carcinogenesis_Homo sapiens_hsa052040.49305347
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.48426907
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46094752
83Sphingolipid metabolism_Homo sapiens_hsa006000.45780973
84Antigen processing and presentation_Homo sapiens_hsa046120.44637407
85Sulfur relay system_Homo sapiens_hsa041220.43628400
86Fatty acid elongation_Homo sapiens_hsa000620.43568072
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43429668
88Cardiac muscle contraction_Homo sapiens_hsa042600.41856777
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40609091
90Complement and coagulation cascades_Homo sapiens_hsa046100.40569813
91Gastric acid secretion_Homo sapiens_hsa049710.39548226
92Insulin resistance_Homo sapiens_hsa049310.39125052
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38236103
94Retinol metabolism_Homo sapiens_hsa008300.36926060
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36707436
96Leishmaniasis_Homo sapiens_hsa051400.35924692
97Synaptic vesicle cycle_Homo sapiens_hsa047210.33179809
98Renin secretion_Homo sapiens_hsa049240.32441381
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.31523840
100Hepatitis C_Homo sapiens_hsa051600.31263723
101Steroid biosynthesis_Homo sapiens_hsa001000.30781953
102Pertussis_Homo sapiens_hsa051330.25818584
103Tight junction_Homo sapiens_hsa045300.23025886
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22701507
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.20314682
106Lysosome_Homo sapiens_hsa041420.20207481
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19904488
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18062226
109Fatty acid biosynthesis_Homo sapiens_hsa000610.17406819
110Glucagon signaling pathway_Homo sapiens_hsa049220.16852133
111Viral myocarditis_Homo sapiens_hsa054160.16631217
112Cocaine addiction_Homo sapiens_hsa050300.14652751
113Hematopoietic cell lineage_Homo sapiens_hsa046400.12084535
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12034599
115Toxoplasmosis_Homo sapiens_hsa051450.11349559
116African trypanosomiasis_Homo sapiens_hsa051430.11254294
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.09895630
118Vitamin B6 metabolism_Homo sapiens_hsa007500.09446135
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07737014
120ABC transporters_Homo sapiens_hsa020100.07616737
121Tyrosine metabolism_Homo sapiens_hsa003500.07593249
122Inositol phosphate metabolism_Homo sapiens_hsa005620.06251824
123One carbon pool by folate_Homo sapiens_hsa006700.05234324
124Insulin secretion_Homo sapiens_hsa049110.04894178
125Bladder cancer_Homo sapiens_hsa052190.04664873
126Influenza A_Homo sapiens_hsa051640.04561039
127Linoleic acid metabolism_Homo sapiens_hsa005910.03549559
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.02075732
129Pancreatic secretion_Homo sapiens_hsa049720.00204499
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0156022
131Choline metabolism in cancer_Homo sapiens_hsa05231-0.0138323

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