AMOT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.58673161
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.31069783
3pre-miRNA processing (GO:0031054)5.07796312
4polarized epithelial cell differentiation (GO:0030859)4.66527377
5regulation of mesoderm development (GO:2000380)4.37166168
6* hippo signaling (GO:0035329)4.27394223
7muscle filament sliding (GO:0030049)4.13231992
8actin-myosin filament sliding (GO:0033275)4.13231992
9sarcoplasmic reticulum calcium ion transport (GO:0070296)4.11686506
10anterior/posterior axis specification, embryo (GO:0008595)3.77102164
11negative regulation of cell fate specification (GO:0009996)3.76385712
12planar cell polarity pathway involved in neural tube closure (GO:0090179)3.74254628
13myofibril assembly (GO:0030239)3.67639009
14plasma membrane repair (GO:0001778)3.66852062
15nuclear pore organization (GO:0006999)3.63580106
16outer ear morphogenesis (GO:0042473)3.61080150
17lymph vessel development (GO:0001945)3.58485223
18nuclear pore complex assembly (GO:0051292)3.57908202
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.56870052
20cardiac myofibril assembly (GO:0055003)3.56683377
21DNA unwinding involved in DNA replication (GO:0006268)3.56589938
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.53894085
23axon extension involved in axon guidance (GO:0048846)3.53894085
24G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.50791439
25actin-mediated cell contraction (GO:0070252)3.50220874
26muscle cell fate commitment (GO:0042693)3.40918501
27regulation of gene silencing by RNA (GO:0060966)3.39643977
28regulation of posttranscriptional gene silencing (GO:0060147)3.39643977
29regulation of gene silencing by miRNA (GO:0060964)3.39643977
30regulation of NFAT protein import into nucleus (GO:0051532)3.37491760
31heterochromatin organization (GO:0070828)3.36604664
32mitotic sister chromatid cohesion (GO:0007064)3.35281164
33bone trabecula formation (GO:0060346)3.34834601
34organ induction (GO:0001759)3.34769783
35chondrocyte proliferation (GO:0035988)3.33396658
36mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.32892650
37regulation of skeletal muscle contraction (GO:0014819)3.32889103
38embryonic foregut morphogenesis (GO:0048617)3.28206910
39negative regulation of DNA repair (GO:0045738)3.27948904
40insulin-like growth factor receptor signaling pathway (GO:0048009)3.23824116
41epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.21924322
42notochord development (GO:0030903)3.17105195
43skeletal muscle contraction (GO:0003009)3.15989535
44endocardial cushion development (GO:0003197)3.15441122
45regulation of sister chromatid cohesion (GO:0007063)3.14527311
46regulation of relaxation of muscle (GO:1901077)3.14257817
47mesenchyme development (GO:0060485)3.08503320
48regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.07807944
49regulation of transforming growth factor beta2 production (GO:0032909)3.07660440
50glucocorticoid receptor signaling pathway (GO:0042921)3.06917241
51negative regulation of embryonic development (GO:0045992)3.06169989
52* gastrulation with mouth forming second (GO:0001702)3.05755833
53establishment of apical/basal cell polarity (GO:0035089)3.05729765
54positive regulation of SMAD protein import into nucleus (GO:0060391)3.04411079
55regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.02327480
56trophectodermal cell differentiation (GO:0001829)3.01571702
57proximal/distal pattern formation (GO:0009954)3.01162571
58establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.01107873
59regulation of hippo signaling (GO:0035330)3.00698683
60* cell migration involved in gastrulation (GO:0042074)2.97800525
61lung-associated mesenchyme development (GO:0060484)2.95240841
62outflow tract septum morphogenesis (GO:0003148)2.94683801
63regulation of cell fate specification (GO:0042659)2.94680273
64dorsal/ventral axis specification (GO:0009950)2.94376911
65protein localization to microtubule (GO:0035372)2.93174641
66striated muscle contraction (GO:0006941)2.92366821
67mesenchymal cell proliferation (GO:0010463)2.92246077
68negative regulation of smooth muscle cell differentiation (GO:0051151)2.91507422
69skeletal muscle fiber development (GO:0048741)2.91048530
70peptidyl-lysine dimethylation (GO:0018027)2.87172721
71regulation of SMAD protein import into nucleus (GO:0060390)2.85613855
72adherens junction assembly (GO:0034333)2.85332703
73sarcomere organization (GO:0045214)2.84773769
74embryonic heart tube development (GO:0035050)2.84629920
75craniofacial suture morphogenesis (GO:0097094)2.82936749
76cardiac muscle hypertrophy (GO:0003300)2.82316501
77embryonic hindlimb morphogenesis (GO:0035116)2.81956029
78hindlimb morphogenesis (GO:0035137)2.80648441
79myotube differentiation (GO:0014902)2.79701841
80regulation of heart morphogenesis (GO:2000826)2.78717853
81metanephric mesenchyme development (GO:0072075)2.77616497
82glycogen catabolic process (GO:0005980)2.77153988
83cranial nerve morphogenesis (GO:0021602)2.76935520
84NLS-bearing protein import into nucleus (GO:0006607)2.75711856
85primitive streak formation (GO:0090009)2.74538035
86negative regulation of axon extension involved in axon guidance (GO:0048843)2.73099285
87mesenchymal-epithelial cell signaling (GO:0060638)2.72359765
88prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.70718700
89cell surface receptor signaling pathway involved in heart development (GO:0061311)2.70156875
90positive regulation of epithelial to mesenchymal transition (GO:0010718)2.69184496
91actin filament-based movement (GO:0030048)2.67152467
92regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.67080693
93non-canonical Wnt signaling pathway (GO:0035567)2.66861603
94cochlea morphogenesis (GO:0090103)2.66722153
95striated muscle hypertrophy (GO:0014897)2.66416562
96midgut development (GO:0007494)2.65904408
97myotube cell development (GO:0014904)2.64231469
98bone morphogenesis (GO:0060349)2.64182637
99regulation of DNA methylation (GO:0044030)2.64030056
100cell proliferation involved in metanephros development (GO:0072203)2.63665362
101regulation of cardioblast proliferation (GO:0003264)2.62883887
102regulation of secondary heart field cardioblast proliferation (GO:0003266)2.62883887
103regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.62830667
104* gastrulation (GO:0007369)2.62766064
105endodermal cell differentiation (GO:0035987)2.62643399
106regulation of skeletal muscle cell differentiation (GO:2001014)2.62632269
107body morphogenesis (GO:0010171)2.61747647
108Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.60895885
109regulation of organ formation (GO:0003156)2.60618771
110cardiac muscle adaptation (GO:0014887)2.60413332
111cardiac muscle hypertrophy in response to stress (GO:0014898)2.60413332
112muscle hypertrophy in response to stress (GO:0003299)2.60413332
113myoblast fusion (GO:0007520)2.60290749
114branching involved in prostate gland morphogenesis (GO:0060442)2.60131199
115epithelial to mesenchymal transition (GO:0001837)2.59155413
116embryonic cranial skeleton morphogenesis (GO:0048701)2.59047553
117artery development (GO:0060840)2.58695799
118regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.57922531
119convergent extension (GO:0060026)2.57786036
120regulation of stem cell maintenance (GO:2000036)2.57705206
121kidney mesenchyme development (GO:0072074)2.57679502
122sister chromatid segregation (GO:0000819)2.57002331
123branching involved in salivary gland morphogenesis (GO:0060445)2.56636379
124response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.56462242
125mesoderm formation (GO:0001707)2.55725738
126cartilage morphogenesis (GO:0060536)2.55432424
127establishment of monopolar cell polarity (GO:0061162)2.55312218
128establishment or maintenance of monopolar cell polarity (GO:0061339)2.55312218
129regulation of establishment of planar polarity (GO:0090175)2.55242610
130regulation of gastrulation (GO:0010470)2.54787682
131negative regulation of catenin import into nucleus (GO:0035414)2.53948956
132regulation of catenin import into nucleus (GO:0035412)2.53892161
133muscle tissue morphogenesis (GO:0060415)2.52061300
134regulation of cardioblast differentiation (GO:0051890)2.52002968
135glucan catabolic process (GO:0009251)2.51872615
136creatine metabolic process (GO:0006600)2.51724590
137histone H2A monoubiquitination (GO:0035518)2.51528975
138regulation of RNA export from nucleus (GO:0046831)2.51184856
139regulation of acrosome reaction (GO:0060046)2.47600042
140anterior/posterior axis specification (GO:0009948)2.47381246
141cranial suture morphogenesis (GO:0060363)2.46973964
142mitotic chromosome condensation (GO:0007076)2.45901456
143negative regulation of chondrocyte differentiation (GO:0032331)2.45786991
144cardiac muscle tissue morphogenesis (GO:0055008)2.43378053
145positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.41202255
146cardiac muscle contraction (GO:0060048)2.40781308
147actomyosin structure organization (GO:0031032)2.40626929
148peripheral nervous system neuron development (GO:0048935)2.38766775
149positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.38685604
150striated muscle adaptation (GO:0014888)2.37515624
151positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.35496584
152adult heart development (GO:0007512)2.35250039
153response to inactivity (GO:0014854)2.32798792
154regulation of actin filament-based movement (GO:1903115)2.31506938
155cardiac ventricle formation (GO:0003211)2.31264897
156postsynaptic membrane organization (GO:0001941)2.30071463
157ventricular septum morphogenesis (GO:0060412)2.29008165
158cellular polysaccharide catabolic process (GO:0044247)2.27045404
159otic vesicle formation (GO:0030916)2.25498373
160cardiac chamber formation (GO:0003207)2.23955832
161positive regulation of DNA-dependent DNA replication (GO:2000105)2.23757325
162cardiac septum morphogenesis (GO:0060411)2.22824123
163DNA replication checkpoint (GO:0000076)2.22761697
164regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.22110118
165nucleus localization (GO:0051647)2.21218316
166mitotic sister chromatid segregation (GO:0000070)2.18838220
167cardiac muscle cell development (GO:0055013)2.18498219
168regulation of cell communication by electrical coupling (GO:0010649)2.16958299
169thyroid gland development (GO:0030878)2.16146210
170skeletal muscle adaptation (GO:0043501)2.15818146
171RNA stabilization (GO:0043489)2.13619293
172mRNA stabilization (GO:0048255)2.13619293
173muscle hypertrophy (GO:0014896)2.12948293
174protein localization to chromosome, centromeric region (GO:0071459)2.12389793
175forelimb morphogenesis (GO:0035136)2.11497550
176negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.09571562
177syncytium formation by plasma membrane fusion (GO:0000768)2.09542592
178negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.08963392
179muscle contraction (GO:0006936)2.08211718
180N-terminal protein amino acid acetylation (GO:0006474)2.08141490
181embryonic skeletal system morphogenesis (GO:0048704)2.07462475
182embryonic forelimb morphogenesis (GO:0035115)2.06670170
183histone H2B ubiquitination (GO:0033523)2.06458384

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.13476572
2E2F7_22180533_ChIP-Seq_HELA_Human5.86333345
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.71418381
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.22450925
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14006871
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.00485788
7AR_21909140_ChIP-Seq_LNCAP_Human3.00334326
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.92842686
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.90985698
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.87324492
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.86886816
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.75242392
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.60284567
14* CBX2_27304074_Chip-Seq_ESCs_Mouse2.54796730
15CLOCK_20551151_ChIP-Seq_293T_Human2.42232524
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29114298
17ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.26027719
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.18961298
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.18706914
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16373197
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15485938
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.14746078
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13071604
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13071604
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.06469947
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.06280081
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.05547389
28HIF1A_21447827_ChIP-Seq_MCF-7_Human2.05130196
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.00614437
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.98287187
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97856464
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95113914
33FUS_26573619_Chip-Seq_HEK293_Human1.90145837
34ISL1_27105846_Chip-Seq_CPCs_Mouse1.84550565
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82409248
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81909935
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80543338
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.79635132
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.79054617
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78052231
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.77898389
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.77731387
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.76736692
44RNF2_27304074_Chip-Seq_NSC_Mouse1.76604859
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.74855970
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.74238662
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70324775
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65939134
49FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.64819998
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.64260326
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59783609
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.58930385
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58141165
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57336416
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.56911412
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56327656
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54480253
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.51751978
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51010850
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47122897
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45379765
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45232917
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43611524
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41975960
65* NANOG_16153702_ChIP-ChIP_HESCs_Human1.41690449
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.40299417
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.39119463
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38632901
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.36889994
70BRD4_25478319_ChIP-Seq_HGPS_Human1.35685434
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34075844
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33517988
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31646907
74CHD1_26751641_Chip-Seq_LNCaP_Human1.31362461
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.31021640
76EWS_26573619_Chip-Seq_HEK293_Human1.30995112
77TCF3_18692474_ChIP-Seq_MESCs_Mouse1.28924406
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.28444871
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26081470
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26036291
81EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.24234686
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24164552
83THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23832707
84SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23738625
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.23142911
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21990893
87* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20579596
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.20218478
89ATF3_27146783_Chip-Seq_COLON_Human1.19632614
90XRN2_22483619_ChIP-Seq_HELA_Human1.18507048
91* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18363688
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18207174
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18133545
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17942694
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17942694
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17942694
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17706810
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16465050
99GBX2_23144817_ChIP-Seq_PC3_Human1.16294693
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15485556
101TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15262759
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14796693
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14733278
104MYC_22102868_ChIP-Seq_BL_Human1.11409750
105EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11323322
106SOX2_16153702_ChIP-ChIP_HESCs_Human1.09913599
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09804428
108RARB_27405468_Chip-Seq_BRAIN_Mouse1.08853795
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07490425
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07472772
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07471430
112POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07350411
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07264030
114HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06867761
115ESR2_21235772_ChIP-Seq_MCF-7_Human1.06731064
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06611319
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06520572
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06285765
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06019412
120POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05665495
121SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03917392
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03917392
123UBF1/2_26484160_Chip-Seq_HMECs_Human1.03679100
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03503428
125EP300_21415370_ChIP-Seq_HL-1_Mouse1.02259398
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02084529
127RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01976739
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01679116
129CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01385934
130TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00065575
131RING1B_27294783_Chip-Seq_NPCs_Mouse0.99831561
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99558336
133SOX9_26525672_Chip-Seq_HEART_Mouse0.99459210
134RACK7_27058665_Chip-Seq_MCF-7_Human0.99335694
135ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96794450
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96765154
137TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96545352
138TP53_22127205_ChIP-Seq_IMR90_Human0.95369232
139* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95269515
140MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95113679
141UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94387518
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94202990
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93648223
144KDM2B_26808549_Chip-Seq_DND41_Human0.93383104
145ESR1_21235772_ChIP-Seq_MCF-7_Human0.93329374
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93292865
147PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92860847
148CREB1_26743006_Chip-Seq_LNCaP_Human0.91926889
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90853394
150CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90224348
151AR_19668381_ChIP-Seq_PC3_Human0.88403701
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88122410
153TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87991775
154STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87161898
155TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86779646
156TAF15_26573619_Chip-Seq_HEK293_Human0.84485644
157SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.82898391
158TTF2_22483619_ChIP-Seq_HELA_Human0.82133811
159CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82034974
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81882741
161TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81476629

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting4.28145286
2MP0003646_muscle_fatigue3.22283073
3MP0003705_abnormal_hypodermis_morpholog3.18898863
4MP0003122_maternal_imprinting3.17722637
5MP0010030_abnormal_orbit_morphology3.07896684
6MP0009053_abnormal_anal_canal2.91974866
7MP0003121_genomic_imprinting2.84823814
8MP0001346_abnormal_lacrimal_gland2.75792863
9MP0000537_abnormal_urethra_morphology2.75649445
10MP0003890_abnormal_embryonic-extraembry2.59742521
11MP0003385_abnormal_body_wall2.56602785
12MP0000749_muscle_degeneration2.27127223
13MP0008438_abnormal_cutaneous_collagen2.20689563
14MP0010352_gastrointestinal_tract_polyps2.19433225
15MP0003937_abnormal_limbs/digits/tail_de2.14298273
16MP0004272_abnormal_basement_membrane2.04208798
17MP0003942_abnormal_urinary_system1.92428533
18MP0003119_abnormal_digestive_system1.84458129
19MP0000428_abnormal_craniofacial_morphol1.83677217
20MP0000733_abnormal_muscle_development1.82290565
21MP0005623_abnormal_meninges_morphology1.81388335
22MP0004197_abnormal_fetal_growth/weight/1.81369069
23MP0000759_abnormal_skeletal_muscle1.78396361
24MP0005187_abnormal_penis_morphology1.75845054
25MP0000534_abnormal_ureter_morphology1.73068521
26MP0003941_abnormal_skin_development1.72758757
27MP0009250_abnormal_appendicular_skeleto1.72690125
28MP0005076_abnormal_cell_differentiation1.71129744
29MP0005503_abnormal_tendon_morphology1.67757169
30* MP0002084_abnormal_developmental_patter1.67394876
31MP0008057_abnormal_DNA_replication1.63130711
32MP0004233_abnormal_muscle_weight1.62367109
33MP0002106_abnormal_muscle_physiology1.57698205
34MP0002932_abnormal_joint_morphology1.57040886
35MP0006292_abnormal_olfactory_placode1.56979211
36* MP0001672_abnormal_embryogenesis/_devel1.56777976
37* MP0005380_embryogenesis_phenotype1.56777976
38MP0006054_spinal_hemorrhage1.55891348
39MP0003567_abnormal_fetal_cardiomyocyte1.55477259
40MP0003935_abnormal_craniofacial_develop1.51778044
41MP0004957_abnormal_blastocyst_morpholog1.51635760
42MP0004036_abnormal_muscle_relaxation1.51068692
43MP0001730_embryonic_growth_arrest1.50241533
44MP0005369_muscle_phenotype1.48971940
45MP0002085_abnormal_embryonic_tissue1.48183454
46MP0003755_abnormal_palate_morphology1.47414983
47* MP0002088_abnormal_embryonic_growth/wei1.46105365
48MP0003283_abnormal_digestive_organ1.46102041
49MP0003115_abnormal_respiratory_system1.45743108
50MP0004270_analgesia1.44372633
51* MP0003984_embryonic_growth_retardation1.44349548
52MP0010094_abnormal_chromosome_stability1.43417704
53MP0009384_cardiac_valve_regurgitation1.43367848
54MP0010234_abnormal_vibrissa_follicle1.43073951
55MP0000747_muscle_weakness1.40501854
56MP0002269_muscular_atrophy1.39998818
57* MP0002086_abnormal_extraembryonic_tissu1.39463709
58MP0004145_abnormal_muscle_electrophysio1.38463328
59MP0000432_abnormal_head_morphology1.34437228
60MP0001299_abnormal_eye_distance/1.34390196
61MP0000778_abnormal_nervous_system1.33928862
62MP0002127_abnormal_cardiovascular_syste1.33684432
63MP0000049_abnormal_middle_ear1.33625241
64MP0002234_abnormal_pharynx_morphology1.33178002
65MP0003315_abnormal_perineum_morphology1.33010238
66MP0002111_abnormal_tail_morphology1.32740921
67MP0004264_abnormal_extraembryonic_tissu1.32284591
68MP0005275_abnormal_skin_tensile1.31358399
69MP0003566_abnormal_cell_adhesion1.30707250
70* MP0001697_abnormal_embryo_size1.29664227
71MP0001293_anophthalmia1.29089913
72MP0009672_abnormal_birth_weight1.23840011
73MP0009703_decreased_birth_body1.21524349
74MP0001849_ear_inflammation1.20380732
75MP0002938_white_spotting1.20302121
76MP0003279_aneurysm1.19604126
77MP0003111_abnormal_nucleus_morphology1.18915658
78MP0002653_abnormal_ependyma_morphology1.18101882
79MP0003718_maternal_effect1.15945048
80MP0002697_abnormal_eye_size1.15206838
81MP0000516_abnormal_urinary_system1.15171872
82MP0005367_renal/urinary_system_phenotyp1.15171872
83MP0002249_abnormal_larynx_morphology1.14075701
84MP0002116_abnormal_craniofacial_bone1.13855957
85MP0005620_abnormal_muscle_contractility1.13545149
86MP0000566_synostosis1.12248995
87MP0004130_abnormal_muscle_cell1.11738799
88MP0000631_abnormal_neuroendocrine_gland1.10537177
89MP0002233_abnormal_nose_morphology1.09231125
90* MP0002925_abnormal_cardiovascular_devel1.08848851
91MP0000003_abnormal_adipose_tissue1.07466307
92MP0000762_abnormal_tongue_morphology1.07111625
93MP0003077_abnormal_cell_cycle1.06169079
94MP0005248_abnormal_Harderian_gland1.06071755
95MP0002109_abnormal_limb_morphology1.04517747
96MP0005508_abnormal_skeleton_morphology1.03331700
97MP0002114_abnormal_axial_skeleton1.03330869
98MP0002092_abnormal_eye_morphology1.02309396
99MP0008932_abnormal_embryonic_tissue1.02072467
100MP0000350_abnormal_cell_proliferation1.01831005
101MP0003938_abnormal_ear_development1.01328961
102MP0004087_abnormal_muscle_fiber1.00334830
103MP0002108_abnormal_muscle_morphology0.98872399
104MP0002160_abnormal_reproductive_system0.97278973
105MP0005646_abnormal_pituitary_gland0.96496893
106MP0000750_abnormal_muscle_regeneration0.96345900
107* MP0002080_prenatal_lethality0.94624404
108MP0003861_abnormal_nervous_system0.92431498
109MP0005023_abnormal_wound_healing0.92327400
110MP0002282_abnormal_trachea_morphology0.91621694
111MP0002177_abnormal_outer_ear0.90113905
112MP0001286_abnormal_eye_development0.89238656
113MP0000751_myopathy0.89049809
114MP0008007_abnormal_cellular_replicative0.88913940
115MP0010630_abnormal_cardiac_muscle0.88797637
116MP0003693_abnormal_embryo_hatching0.88367280
117MP0003091_abnormal_cell_migration0.88204809
118MP0004133_heterotaxia0.88107704
119MP0001915_intracranial_hemorrhage0.87661469
120MP0000266_abnormal_heart_morphology0.86651716
121MP0002115_abnormal_skeleton_extremities0.86480785
122MP0002896_abnormal_bone_mineralization0.86331076
123MP0006138_congestive_heart_failure0.85896672
124MP0002081_perinatal_lethality0.85016874
125MP0000163_abnormal_cartilage_morphology0.84857124
126MP0005330_cardiomyopathy0.83492742
127MP0002089_abnormal_postnatal_growth/wei0.83044151
128MP0000579_abnormal_nail_morphology0.81850188
129MP0004859_abnormal_synaptic_plasticity0.77458263
130MP0008058_abnormal_DNA_repair0.76684002
131MP0000955_abnormal_spinal_cord0.76242747
132MP0004134_abnormal_chest_morphology0.75840759
133MP0002734_abnormal_mechanical_nocicepti0.75502909
134* MP0002152_abnormal_brain_morphology0.75435255
135MP0004858_abnormal_nervous_system0.74930681
136MP0003136_yellow_coat_color0.72976346
137MP0001486_abnormal_startle_reflex0.71241726
138MP0000678_abnormal_parathyroid_gland0.70658461
139MP0008789_abnormal_olfactory_epithelium0.70581927

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.83772163
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.12450157
3Short 4th metacarpal (HP:0010044)4.12450157
4Shallow orbits (HP:0000586)3.98276998
5Myopathic facies (HP:0002058)3.65703272
6Protrusio acetabuli (HP:0003179)3.58213769
7Abnormality of the 4th metacarpal (HP:0010012)3.32444134
8Muscle hypertrophy of the lower extremities (HP:0008968)3.21431051
9Renal duplication (HP:0000075)3.13690663
10Hepatoblastoma (HP:0002884)3.06570708
11Subaortic stenosis (HP:0001682)2.95746988
12Abnormality of the left ventricular outflow tract (HP:0011103)2.95746988
13Calf muscle hypertrophy (HP:0008981)2.95014718
14High anterior hairline (HP:0009890)2.91640951
15Type 1 muscle fiber predominance (HP:0003803)2.88055128
16Abnormality of the phalanges of the hallux (HP:0010057)2.83665893
17Broad thumb (HP:0011304)2.70824185
18Muscle fiber inclusion bodies (HP:0100299)2.66581596
19Premature rupture of membranes (HP:0001788)2.63675143
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.61291309
21EMG: myopathic abnormalities (HP:0003458)2.56327297
22Abnormality of the calcaneus (HP:0008364)2.55941487
23Double outlet right ventricle (HP:0001719)2.47499720
24Congenital malformation of the right heart (HP:0011723)2.47499720
25Rimmed vacuoles (HP:0003805)2.43058066
26Ankle contracture (HP:0006466)2.42299929
27Abnormality of the calf musculature (HP:0001430)2.41119346
28Centrally nucleated skeletal muscle fibers (HP:0003687)2.36031960
29Transposition of the great arteries (HP:0001669)2.34641409
30Abnormal connection of the cardiac segments (HP:0011545)2.34641409
31Abnormal ventriculo-arterial connection (HP:0011563)2.34641409
32Selective tooth agenesis (HP:0001592)2.31051125
33Broad metatarsal (HP:0001783)2.30079272
34Periauricular skin pits (HP:0100277)2.27664458
35Preauricular pit (HP:0004467)2.27664458
36Mesomelia (HP:0003027)2.27590885
37Broad toe (HP:0001837)2.26231910
38Abnormality of the distal phalanx of the thumb (HP:0009617)2.25375960
39Long clavicles (HP:0000890)2.23085237
40Wrist flexion contracture (HP:0001239)2.22556149
41Exercise-induced muscle cramps (HP:0003710)2.21761438
42Cervical subluxation (HP:0003308)2.21698499
43Broad phalanges of the hand (HP:0009768)2.20906758
44Abnormality of the aortic arch (HP:0012303)2.17791583
45Nemaline bodies (HP:0003798)2.17379712
46Broad finger (HP:0001500)2.16945531
47Distal arthrogryposis (HP:0005684)2.16355206
48Hypoplasia of the iris (HP:0007676)2.15843974
49Coronal craniosynostosis (HP:0004440)2.15481028
50Cutaneous finger syndactyly (HP:0010554)2.14019737
51Calcaneovalgus deformity (HP:0001848)2.13876606
52Microglossia (HP:0000171)2.12210645
53Septate vagina (HP:0001153)2.12094988
54Abnormality of the parietal bone (HP:0002696)2.11065909
55Muscle stiffness (HP:0003552)2.10794735
56Hyporeflexia of lower limbs (HP:0002600)2.10676989
57Round ear (HP:0100830)2.10571403
58Broad long bones (HP:0005622)2.10168522
59Pelvic girdle muscle weakness (HP:0003749)2.09705116
60Asymmetry of the thorax (HP:0001555)2.09415823
61Colon cancer (HP:0003003)2.09406853
62Deviation of the thumb (HP:0009603)2.09215489
63Bundle branch block (HP:0011710)2.08902848
64Trigonocephaly (HP:0000243)2.08677732
65Spinal cord lesions (HP:0100561)2.08441371
66Syringomyelia (HP:0003396)2.08441371
67Broad phalanx (HP:0006009)2.05249000
68Skin pits (HP:0100276)2.03836009
69Deviation of the hallux (HP:0010051)2.03827682
70Mitral valve prolapse (HP:0001634)2.03333132
71Absent phalangeal crease (HP:0006109)2.01238321
72Scapular winging (HP:0003691)2.00980712
73Myoglobinuria (HP:0002913)2.00785308
74Bladder diverticulum (HP:0000015)2.00144430
75Increased connective tissue (HP:0009025)1.99276445
76Cutaneous syndactyly (HP:0012725)1.99226962
77Midline defect of the nose (HP:0004122)1.97014564
78Cerebral aneurysm (HP:0004944)1.96886149
79Increased nuchal translucency (HP:0010880)1.96834701
80Frequent falls (HP:0002359)1.96381993
81Abnormality of skeletal muscle fiber size (HP:0012084)1.96377291
82Shawl scrotum (HP:0000049)1.95977431
83Short humerus (HP:0005792)1.95845538
84Increased density of long bones (HP:0006392)1.95230458
85Abnormality of the ischium (HP:0003174)1.94489279
86Short 5th finger (HP:0009237)1.94056015
87Deformed tarsal bones (HP:0008119)1.93961692
88Neck muscle weakness (HP:0000467)1.93220658
89Hyperacusis (HP:0010780)1.93074285
90Diastasis recti (HP:0001540)1.92938244
91Fetal akinesia sequence (HP:0001989)1.92594979
92Skin tags (HP:0010609)1.91139144
93Increased variability in muscle fiber diameter (HP:0003557)1.90428853
94Bowel diverticulosis (HP:0005222)1.88957693
95Urethral obstruction (HP:0000796)1.86660650
96Areflexia of lower limbs (HP:0002522)1.86344632
97Dysmetric saccades (HP:0000641)1.86253140
98Difficulty running (HP:0009046)1.84924340
99Tarsal synostosis (HP:0008368)1.84674833
100Preauricular skin tag (HP:0000384)1.84622480
101Hallux valgus (HP:0001822)1.83618402
102Abnormality of chromosome segregation (HP:0002916)1.82478451
103Abnormality of the musculature of the pelvis (HP:0001469)1.82033772
104Abnormality of the hip-girdle musculature (HP:0001445)1.82033772
105Bicornuate uterus (HP:0000813)1.81891727
106Renal dysplasia (HP:0000110)1.81204586
107Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.80840891
108Short 1st metacarpal (HP:0010034)1.80840891
109Aplasia/hypoplasia of the humerus (HP:0006507)1.80702588
110Shoulder girdle muscle weakness (HP:0003547)1.80318813
111Broad hallux (HP:0010055)1.80153032
112Rectal prolapse (HP:0002035)1.79881719
113Ulnar deviation of the wrist (HP:0003049)1.78623848
114Proximal placement of thumb (HP:0009623)1.78218167
115Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77571219
116Abnormality of the parathyroid morphology (HP:0011766)1.76793753
117Renovascular hypertension (HP:0100817)1.76018921
118Pseudobulbar signs (HP:0002200)1.75964627
119Lip pit (HP:0100267)1.75337998
120Esophageal atresia (HP:0002032)1.75085231
121Anal stenosis (HP:0002025)1.74392868
122Aortic aneurysm (HP:0004942)1.73895993
123Difficulty climbing stairs (HP:0003551)1.73780321
124Short phalanx of the thumb (HP:0009660)1.73479004
125Synostosis of carpal bones (HP:0005048)1.72719149
126Muscle fiber splitting (HP:0003555)1.72567238
127Truncal obesity (HP:0001956)1.71754855
128Myotonia (HP:0002486)1.71700254
129Rhabdomyolysis (HP:0003201)1.71694354
130Hypoplastic labia majora (HP:0000059)1.71170847
131Abnormality of the shoulder girdle musculature (HP:0001435)1.70561445
132Synostosis involving bones of the feet (HP:0009140)1.68996230
133Synostosis involving bones of the lower limbs (HP:0009138)1.68996230
134Hypoplastic heart (HP:0001961)1.68801602
135Preaxial foot polydactyly (HP:0001841)1.68476085
136Lymphangioma (HP:0100764)1.68469131
137Back pain (HP:0003418)1.67774204
138Ectopic kidney (HP:0000086)1.67716235
139Dilatation of the ascending aorta (HP:0005111)1.67643587
140Turricephaly (HP:0000262)1.67247178
141Wide anterior fontanel (HP:0000260)1.66587652
142Buphthalmos (HP:0000557)1.66180147
143Fibular aplasia (HP:0002990)1.65407909
144Enlarged penis (HP:0000040)1.64751154
145Hypoplastic left heart (HP:0004383)1.64627124
146Supernumerary ribs (HP:0005815)1.64608177
147Ulnar deviation of finger (HP:0009465)1.63639047
148Abnormality of the fetal cardiovascular system (HP:0010948)1.63399425
149Abnormal umbilical cord blood vessels (HP:0011403)1.63399425
150Single umbilical artery (HP:0001195)1.63399425
151Radial bowing (HP:0002986)1.63001947
152Abnormal number of incisors (HP:0011064)1.62946201
153Abnormal finger flexion creases (HP:0006143)1.62912168
154Ulnar bowing (HP:0003031)1.62831040
155Hypoplastic ischia (HP:0003175)1.60562382
156Hip contracture (HP:0003273)1.58865752
157Ventricular tachycardia (HP:0004756)1.58800463
158Progressive muscle weakness (HP:0003323)1.58756834
159Gout (HP:0001997)1.57135154
160Abnormality of the middle phalanges of the toes (HP:0010183)1.54708241
161Partial duplication of thumb phalanx (HP:0009944)1.53399831
162Malignant hyperthermia (HP:0002047)1.52535054
163EMG: neuropathic changes (HP:0003445)1.51994562
164Abnormality of cochlea (HP:0000375)1.50112710
165Bifid tongue (HP:0010297)1.49222240
166Broad distal phalanx of finger (HP:0009836)1.46483970
167Bilateral microphthalmos (HP:0007633)1.45557722
168Maternal diabetes (HP:0009800)1.45544367
169Partial duplication of the phalanx of hand (HP:0009999)1.45508762
170Anterior segment dysgenesis (HP:0007700)1.44384162
171Pheochromocytoma (HP:0002666)1.44069532
172Hyperkalemia (HP:0002153)1.42857353
173Thin ribs (HP:0000883)1.42851663
174Generalized muscle weakness (HP:0003324)1.42822361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.14259474
2TTN3.70227177
3LATS23.46347485
4CDK123.05107328
5PDGFRA2.57830645
6TRIB32.51274955
7CDC72.41393097
8NEK12.18141061
9PKN22.06708504
10DDR22.06183461
11MAP3K101.96551656
12EEF2K1.87778345
13MARK11.83780693
14NEK21.76347039
15PTK61.75757312
16STK38L1.64617596
17STK31.63884511
18TGFBR11.63032736
19EPHB21.61528553
20FGFR11.60242500
21RIPK11.54071359
22OBSCN1.49538319
23MTOR1.49100660
24RPS6KB21.47945469
25CASK1.47340665
26MAP3K91.46336252
27TTK1.43713069
28PAK41.39760499
29TSSK61.32117438
30SCYL21.31187598
31PTK21.31138520
32BRD41.30831650
33MAP3K81.26462690
34PASK1.26424491
35PAK21.25993735
36EPHA41.24795985
37NTRK21.24755584
38PLK41.24181853
39PLK31.22071133
40MKNK11.21646764
41CDK61.21526962
42PRKD31.20692519
43TNIK1.20241440
44AKT31.16978138
45SIK11.16460416
46EPHA21.16231179
47CSNK1G31.13682498
48CSNK1G11.12822896
49ALK1.07546476
50SMG11.07337012
51BMX1.06129962
52CAMK41.05524514
53DMPK1.02462631
54WEE10.96519624
55FGFR20.95761052
56CSNK1G20.95681791
57FER0.94548805
58KSR10.94492247
59ICK0.94447530
60LRRK20.93876326
61AKT20.93852309
62PINK10.93793197
63STK240.93736866
64MELK0.91122787
65STK100.88182804
66CDK40.84299372
67PBK0.83522492
68CHEK10.82695693
69AURKB0.82486419
70PLK10.81132738
71PAK30.80951957
72CCNB10.80191390
73CDK70.78103005
74BRAF0.78099748
75ERBB30.76910047
76NTRK30.76505068
77BRSK10.74484038
78CAMK1D0.74355900
79PDGFRB0.73850485
80SGK30.71963557
81CAMK1G0.71194798
82PRKAA10.68659495
83MAPK100.68614966
84ARAF0.68158802
85ERBB20.67374591
86PKN10.67226162
87AURKA0.66251278
88MAP2K30.62509404
89TYRO30.62122350
90MAP2K40.61990986
91STK390.61474201
92ATR0.60790555
93ROCK10.60053480
94CSNK1E0.60044579
95FRK0.58166119
96MAP3K130.58157148
97SGK20.58025220
98* CDK20.57752563
99ATM0.57676136
100MET0.57455238
101BUB10.57121545
102MAPKAPK50.57003765
103MKNK20.56789032
104CHEK20.56443269
105LIMK10.55527360
106STK160.55226753
107SRPK10.53817238
108PNCK0.53774516
109CDK10.52973843
110PRKAA20.52854478
111MAP3K70.52156427
112STK380.52093495
113RPS6KB10.51492526
114GSK3B0.50997183
115CDK11A0.50153982
116MAPK130.49785331
117CDK150.48568000
118TRIM280.47773367
119NEK90.47047157
120PRKDC0.46879551
121TESK10.46512493
122CAMK10.46343469
123CDK180.45475350
124NUAK10.44672063
125CSNK1D0.43952987
126KSR20.43439042
127PRKACB0.42895600
128CSNK1A1L0.42518643
129SGK4940.42358560
130SGK2230.42358560
131MAPK120.42317260
132PRKG10.41912952
133CDK90.41789174
134CAMK2G0.41131917
135CDK30.41081799
136PLK20.40154242
137ROCK20.38732948
138CDK190.38721405
139PHKG10.38314936
140PHKG20.38314936
141ILK0.37779658
142TRPM70.36103189
143RPS6KA40.35503036
144AKT10.35187547
145CDC42BPA0.32521326
146MAP2K10.32178177
147MAPK140.30541356

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.44182638
2* Hippo signaling pathway_Homo sapiens_hsa043902.90646434
3Hedgehog signaling pathway_Homo sapiens_hsa043402.77575333
4Adherens junction_Homo sapiens_hsa045202.57881376
5Proteoglycans in cancer_Homo sapiens_hsa052052.23991843
6Cell cycle_Homo sapiens_hsa041102.18812127
7Circadian rhythm_Homo sapiens_hsa047102.18438357
8Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.17941233
9MicroRNAs in cancer_Homo sapiens_hsa052062.00715766
10Tight junction_Homo sapiens_hsa045302.00167516
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.99041405
12TGF-beta signaling pathway_Homo sapiens_hsa043501.93877585
13Focal adhesion_Homo sapiens_hsa045101.93272692
14RNA transport_Homo sapiens_hsa030131.89529620
15ECM-receptor interaction_Homo sapiens_hsa045121.79220566
16Wnt signaling pathway_Homo sapiens_hsa043101.65386143
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.64000050
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59778292
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.56118809
20Small cell lung cancer_Homo sapiens_hsa052221.55061555
21One carbon pool by folate_Homo sapiens_hsa006701.52875828
22Bladder cancer_Homo sapiens_hsa052191.51423034
23Spliceosome_Homo sapiens_hsa030401.49552008
24Arginine and proline metabolism_Homo sapiens_hsa003301.49365933
25mRNA surveillance pathway_Homo sapiens_hsa030151.48606927
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.46241476
27Nitrogen metabolism_Homo sapiens_hsa009101.41944804
28Dilated cardiomyopathy_Homo sapiens_hsa054141.41241005
29mTOR signaling pathway_Homo sapiens_hsa041501.36920281
30Melanogenesis_Homo sapiens_hsa049161.36523915
31Oocyte meiosis_Homo sapiens_hsa041141.35849994
32Lysine degradation_Homo sapiens_hsa003101.33958196
33Cardiac muscle contraction_Homo sapiens_hsa042601.31757114
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.30619264
35Melanoma_Homo sapiens_hsa052181.29916051
36p53 signaling pathway_Homo sapiens_hsa041151.23333615
37HTLV-I infection_Homo sapiens_hsa051661.23315492
38Chronic myeloid leukemia_Homo sapiens_hsa052201.21153327
39Prostate cancer_Homo sapiens_hsa052151.19991646
40Colorectal cancer_Homo sapiens_hsa052101.19457656
41Endometrial cancer_Homo sapiens_hsa052131.18562185
42Pathways in cancer_Homo sapiens_hsa052001.17968971
43Thyroid cancer_Homo sapiens_hsa052161.17610480
44DNA replication_Homo sapiens_hsa030301.15960117
45Glioma_Homo sapiens_hsa052141.09637824
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04814929
47Mismatch repair_Homo sapiens_hsa034301.02894707
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02809159
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02726565
50Long-term potentiation_Homo sapiens_hsa047201.02651802
51Oxytocin signaling pathway_Homo sapiens_hsa049211.02600596
52Viral myocarditis_Homo sapiens_hsa054161.02504730
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.02260376
54Arginine biosynthesis_Homo sapiens_hsa002201.02233232
55Axon guidance_Homo sapiens_hsa043601.01553592
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01090096
57Pyruvate metabolism_Homo sapiens_hsa006201.00130387
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99231537
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98032598
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98011933
61Folate biosynthesis_Homo sapiens_hsa007900.97515621
62Notch signaling pathway_Homo sapiens_hsa043300.96900165
63Rap1 signaling pathway_Homo sapiens_hsa040150.96609679
64Amoebiasis_Homo sapiens_hsa051460.94064944
65AMPK signaling pathway_Homo sapiens_hsa041520.93902868
66Propanoate metabolism_Homo sapiens_hsa006400.92957030
67FoxO signaling pathway_Homo sapiens_hsa040680.90252380
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.89695205
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87196467
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86967516
71Gastric acid secretion_Homo sapiens_hsa049710.85796392
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84623136
73Biosynthesis of amino acids_Homo sapiens_hsa012300.83787361
74Calcium signaling pathway_Homo sapiens_hsa040200.83234522
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82051827
76Circadian entrainment_Homo sapiens_hsa047130.81987824
77HIF-1 signaling pathway_Homo sapiens_hsa040660.81602271
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81460086
79Basal transcription factors_Homo sapiens_hsa030220.80902049
80Renal cell carcinoma_Homo sapiens_hsa052110.80192952
81Fanconi anemia pathway_Homo sapiens_hsa034600.80135583
82Homologous recombination_Homo sapiens_hsa034400.79957408
83Glucagon signaling pathway_Homo sapiens_hsa049220.79762384
84Insulin secretion_Homo sapiens_hsa049110.79613476
85Viral carcinogenesis_Homo sapiens_hsa052030.79249293
86Sulfur relay system_Homo sapiens_hsa041220.78924864
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77634437
88Protein digestion and absorption_Homo sapiens_hsa049740.77129288
89Amphetamine addiction_Homo sapiens_hsa050310.75855087
90Insulin resistance_Homo sapiens_hsa049310.74539231
91Dopaminergic synapse_Homo sapiens_hsa047280.74017324
92Insulin signaling pathway_Homo sapiens_hsa049100.72895838
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72548737
94Non-homologous end-joining_Homo sapiens_hsa034500.72542701
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72493391
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70886443
97Inositol phosphate metabolism_Homo sapiens_hsa005620.70109440
98Estrogen signaling pathway_Homo sapiens_hsa049150.66985131
99Gap junction_Homo sapiens_hsa045400.66463892
100Long-term depression_Homo sapiens_hsa047300.66087554
101RNA degradation_Homo sapiens_hsa030180.66018449
102GnRH signaling pathway_Homo sapiens_hsa049120.65510031
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65155494
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64310794
105Choline metabolism in cancer_Homo sapiens_hsa052310.63941042
106Nucleotide excision repair_Homo sapiens_hsa034200.63309915
107Nicotine addiction_Homo sapiens_hsa050330.62967681
108Non-small cell lung cancer_Homo sapiens_hsa052230.62851370
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62608947
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.62078702
111Purine metabolism_Homo sapiens_hsa002300.61586581
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60710997
113Dorso-ventral axis formation_Homo sapiens_hsa043200.60296136
114Pancreatic cancer_Homo sapiens_hsa052120.58586124
115cAMP signaling pathway_Homo sapiens_hsa040240.57962790
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57823299
117Cholinergic synapse_Homo sapiens_hsa047250.57511433
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55741920
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52999462
120Vitamin B6 metabolism_Homo sapiens_hsa007500.51858073
121Cocaine addiction_Homo sapiens_hsa050300.51839393
122Carbon metabolism_Homo sapiens_hsa012000.51745378
123Ovarian steroidogenesis_Homo sapiens_hsa049130.51283277
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50819777
125VEGF signaling pathway_Homo sapiens_hsa043700.48613817
126GABAergic synapse_Homo sapiens_hsa047270.46203206
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46148389
128Thyroid hormone synthesis_Homo sapiens_hsa049180.44677012
129MAPK signaling pathway_Homo sapiens_hsa040100.42980404
130Base excision repair_Homo sapiens_hsa034100.42622170
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40305619
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40059853
133Bile secretion_Homo sapiens_hsa049760.38598353
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36297678
135Systemic lupus erythematosus_Homo sapiens_hsa053220.35270525
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35039776
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34176514
138ErbB signaling pathway_Homo sapiens_hsa040120.34137370

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »