

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | chondrocyte proliferation (GO:0035988) | 5.16506698 |
| 2 | protein heterotrimerization (GO:0070208) | 4.68695141 |
| 3 | collagen fibril organization (GO:0030199) | 4.67402811 |
| 4 | wound healing, spreading of epidermal cells (GO:0035313) | 4.60506512 |
| 5 | axon extension involved in axon guidance (GO:0048846) | 4.44592877 |
| 6 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 4.44592877 |
| 7 | regulation of hippo signaling (GO:0035330) | 4.40769412 |
| 8 | endodermal cell differentiation (GO:0035987) | 4.32329004 |
| 9 | epithelial cell-cell adhesion (GO:0090136) | 4.15316914 |
| 10 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 4.12532991 |
| 11 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 4.08111757 |
| 12 | wound healing, spreading of cells (GO:0044319) | 4.06095771 |
| 13 | cell adhesion mediated by integrin (GO:0033627) | 4.04461816 |
| 14 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 4.00562903 |
| 15 | basement membrane organization (GO:0071711) | 3.94169192 |
| 16 | glomerular basement membrane development (GO:0032836) | 3.89673217 |
| 17 | skin morphogenesis (GO:0043589) | 3.86607055 |
| 18 | polarized epithelial cell differentiation (GO:0030859) | 3.85108618 |
| 19 | endocardial cushion development (GO:0003197) | 3.81521406 |
| 20 | paraxial mesoderm development (GO:0048339) | 3.77458751 |
| 21 | bone trabecula formation (GO:0060346) | 3.73926046 |
| 22 | vascular endothelial growth factor signaling pathway (GO:0038084) | 3.63189093 |
| 23 | negative regulation of fatty acid transport (GO:2000192) | 3.60764973 |
| 24 | regulation of tight junction assembly (GO:2000810) | 3.60371089 |
| 25 | plasma membrane repair (GO:0001778) | 3.57739650 |
| 26 | establishment of apical/basal cell polarity (GO:0035089) | 3.57443693 |
| 27 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 3.56730321 |
| 28 | branching involved in salivary gland morphogenesis (GO:0060445) | 3.53188669 |
| 29 | sequestering of extracellular ligand from receptor (GO:0035581) | 3.52507987 |
| 30 | renal filtration (GO:0097205) | 3.51946986 |
| 31 | * hippo signaling (GO:0035329) | 3.51831542 |
| 32 | cell migration involved in sprouting angiogenesis (GO:0002042) | 3.49790843 |
| 33 | negative regulation of chondrocyte differentiation (GO:0032331) | 3.46626011 |
| 34 | adherens junction assembly (GO:0034333) | 3.43044812 |
| 35 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.38854233 |
| 36 | cell-substrate junction assembly (GO:0007044) | 3.37218441 |
| 37 | positive regulation of osteoblast proliferation (GO:0033690) | 3.28067601 |
| 38 | desmosome organization (GO:0002934) | 3.27971471 |
| 39 | apoptotic cell clearance (GO:0043277) | 3.23037136 |
| 40 | protein localization to cell surface (GO:0034394) | 3.21333293 |
| 41 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 3.20006818 |
| 42 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.13117378 |
| 43 | regulation of gene silencing by miRNA (GO:0060964) | 3.13117378 |
| 44 | regulation of gene silencing by RNA (GO:0060966) | 3.13117378 |
| 45 | negative regulation of fibrinolysis (GO:0051918) | 3.10001314 |
| 46 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 3.06933169 |
| 47 | atrioventricular valve morphogenesis (GO:0003181) | 3.06801627 |
| 48 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 3.05926291 |
| 49 | negative regulation of cartilage development (GO:0061037) | 3.05893316 |
| 50 | collagen metabolic process (GO:0032963) | 3.05770070 |
| 51 | positive regulation of epithelial to mesenchymal transition (GO:0010718) | 3.03798137 |
| 52 | regulation of SMAD protein import into nucleus (GO:0060390) | 3.01009106 |
| 53 | establishment of monopolar cell polarity (GO:0061162) | 2.99309601 |
| 54 | establishment or maintenance of monopolar cell polarity (GO:0061339) | 2.99309601 |
| 55 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.98856261 |
| 56 | endothelial cell morphogenesis (GO:0001886) | 2.97635665 |
| 57 | cell-substrate adherens junction assembly (GO:0007045) | 2.97026617 |
| 58 | focal adhesion assembly (GO:0048041) | 2.97026617 |
| 59 | glomerular filtration (GO:0003094) | 2.96818075 |
| 60 | lung-associated mesenchyme development (GO:0060484) | 2.96734659 |
| 61 | cellular response to vitamin (GO:0071295) | 2.94297816 |
| 62 | atrial septum morphogenesis (GO:0060413) | 2.93190320 |
| 63 | metanephric mesenchyme development (GO:0072075) | 2.92714618 |
| 64 | negative regulation of smooth muscle cell migration (GO:0014912) | 2.92080182 |
| 65 | multicellular organismal macromolecule metabolic process (GO:0044259) | 2.91660560 |
| 66 | regulation of establishment of planar polarity (GO:0090175) | 2.91620654 |
| 67 | substrate adhesion-dependent cell spreading (GO:0034446) | 2.90854248 |
| 68 | craniofacial suture morphogenesis (GO:0097094) | 2.90751160 |
| 69 | collagen catabolic process (GO:0030574) | 2.90664940 |
| 70 | blood vessel endothelial cell migration (GO:0043534) | 2.88516299 |
| 71 | epoxygenase P450 pathway (GO:0019373) | 2.88244959 |
| 72 | peptidyl-proline hydroxylation (GO:0019511) | 2.87474900 |
| 73 | lens morphogenesis in camera-type eye (GO:0002089) | 2.86929135 |
| 74 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 2.85306248 |
| 75 | hemidesmosome assembly (GO:0031581) | 2.84525968 |
| 76 | mesenchymal-epithelial cell signaling (GO:0060638) | 2.84317182 |
| 77 | lymphangiogenesis (GO:0001946) | 2.84146642 |
| 78 | extracellular matrix disassembly (GO:0022617) | 2.83357164 |
| 79 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 2.83160463 |
| 80 | low-density lipoprotein particle clearance (GO:0034383) | 2.81129320 |
| 81 | stress fiber assembly (GO:0043149) | 2.81070762 |
| 82 | kidney mesenchyme development (GO:0072074) | 2.80546929 |
| 83 | negative regulation of catenin import into nucleus (GO:0035414) | 2.80311244 |
| 84 | non-canonical Wnt signaling pathway (GO:0035567) | 2.79442580 |
| 85 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.77602236 |
| 86 | multicellular organismal metabolic process (GO:0044236) | 2.77147153 |
| 87 | regulation of axon guidance (GO:1902667) | 2.76905488 |
| 88 | positive regulation of blood vessel endothelial cell migration (GO:0043536) | 2.75181848 |
| 89 | regulation of gastrulation (GO:0010470) | 2.74945031 |
| 90 | convergent extension (GO:0060026) | 2.74934160 |
| 91 | negative regulation of embryonic development (GO:0045992) | 2.74075053 |
| 92 | regulation of transforming growth factor beta2 production (GO:0032909) | 2.73284430 |
| 93 | regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307) | 2.69655991 |
| 94 | mesenchyme development (GO:0060485) | 2.69489455 |
| 95 | multicellular organismal catabolic process (GO:0044243) | 2.68932048 |
| 96 | glomerular visceral epithelial cell development (GO:0072015) | 2.68325660 |
| 97 | glomerular epithelial cell development (GO:0072310) | 2.68266020 |
| 98 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 2.67569005 |
| 99 | cellular response to vascular endothelial growth factor stimulus (GO:0035924) | 2.65698606 |
| 100 | regulation of G0 to G1 transition (GO:0070316) | 2.65356951 |
| 101 | extracellular matrix assembly (GO:0085029) | 2.63517536 |
| 102 | mesodermal cell differentiation (GO:0048333) | 2.61046246 |
| 103 | protein hydroxylation (GO:0018126) | 2.60651590 |
| 104 | neural crest cell development (GO:0014032) | 2.59780467 |
| 105 | positive regulation of cartilage development (GO:0061036) | 2.57338412 |
| 106 | regulation of cartilage development (GO:0061035) | 2.56134521 |
| 107 | cochlea morphogenesis (GO:0090103) | 2.53559152 |
| 108 | positive regulation of p38MAPK cascade (GO:1900745) | 2.53197511 |
| 109 | cranial suture morphogenesis (GO:0060363) | 2.53187230 |
| 110 | notochord development (GO:0030903) | 2.52776392 |
| 111 | regulation of cardioblast differentiation (GO:0051890) | 2.51655374 |
| 112 | hypotonic response (GO:0006971) | 2.51505207 |
| 113 | regulation of plasminogen activation (GO:0010755) | 2.50563352 |
| 114 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.50023100 |
| 115 | camera-type eye morphogenesis (GO:0048593) | 2.49258575 |
| 116 | fibroblast migration (GO:0010761) | 2.49010609 |
| 117 | apoptotic process involved in morphogenesis (GO:0060561) | 2.48778176 |
| 118 | lung epithelium development (GO:0060428) | 2.48676979 |
| 119 | cardiac septum morphogenesis (GO:0060411) | 2.47665878 |
| 120 | embryonic camera-type eye development (GO:0031076) | 2.47380707 |
| 121 | negative regulation of stem cell proliferation (GO:2000647) | 2.46313113 |
| 122 | cell migration involved in heart development (GO:0060973) | 2.45530404 |
| 123 | chondrocyte development (GO:0002063) | 2.45431007 |
| 124 | COPI coating of Golgi vesicle (GO:0048205) | 2.43343112 |
| 125 | Golgi transport vesicle coating (GO:0048200) | 2.43343112 |
| 126 | adherens junction organization (GO:0034332) | 2.42318240 |
| 127 | gap junction assembly (GO:0016264) | 2.41304385 |
| 128 | heparan sulfate proteoglycan biosynthetic process (GO:0015012) | 2.40169449 |
| 129 | semaphorin-plexin signaling pathway (GO:0071526) | 2.39483214 |
| 130 | heart valve morphogenesis (GO:0003179) | 2.38420207 |
| 131 | pericardium development (GO:0060039) | 2.38017520 |
| 132 | substrate-dependent cell migration (GO:0006929) | 2.37263865 |
| 133 | ventricular septum development (GO:0003281) | 2.37177088 |
| 134 | type B pancreatic cell proliferation (GO:0044342) | 2.36600197 |
| 135 | muscle cell migration (GO:0014812) | 2.35695685 |
| 136 | negative regulation of BMP signaling pathway (GO:0030514) | 2.34189887 |
| 137 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 2.32891499 |
| 138 | regulation of osteoblast proliferation (GO:0033688) | 2.32558660 |
| 139 | regulation of branching involved in salivary gland morphogenesis (GO:0060693) | 2.31742287 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 6.30999011 |
| 2 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 5.47171226 |
| 3 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 4.58433894 |
| 4 | CLOCK_20551151_ChIP-Seq_293T_Human | 3.68267872 |
| 5 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 3.21417414 |
| 6 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.98316045 |
| 7 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 2.67819873 |
| 8 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 2.65211379 |
| 9 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.64597562 |
| 10 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 2.58485814 |
| 11 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 2.49931462 |
| 12 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.32726142 |
| 13 | * EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 2.14816362 |
| 14 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.13792272 |
| 15 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.03142779 |
| 16 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 2.00262560 |
| 17 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.96500700 |
| 18 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.93581530 |
| 19 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.93498925 |
| 20 | * TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.92096399 |
| 21 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.90184177 |
| 22 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.89170461 |
| 23 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.87357113 |
| 24 | * CJUN_26792858_Chip-Seq_BT549_Human | 1.86791718 |
| 25 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.82296630 |
| 26 | * PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.81518533 |
| 27 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.79676098 |
| 28 | * ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.78194828 |
| 29 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.74819255 |
| 30 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.74744023 |
| 31 | * SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.72866132 |
| 32 | * SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.72866132 |
| 33 | * TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.72283357 |
| 34 | * BRD4_25478319_ChIP-Seq_HGPS_Human | 1.70809876 |
| 35 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.69510460 |
| 36 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.68870968 |
| 37 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.67808762 |
| 38 | * ATF3_27146783_Chip-Seq_COLON_Human | 1.67520433 |
| 39 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.66578707 |
| 40 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.66578707 |
| 41 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.66200510 |
| 42 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.65174577 |
| 43 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.63487709 |
| 44 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.62457539 |
| 45 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.60017369 |
| 46 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.57062874 |
| 47 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.57034193 |
| 48 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.55651112 |
| 49 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.55522376 |
| 50 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.53905905 |
| 51 | * ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.53831509 |
| 52 | * ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.53790387 |
| 53 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.45846129 |
| 54 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.44274425 |
| 55 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.44102756 |
| 56 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.43607486 |
| 57 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.43607486 |
| 58 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.43607486 |
| 59 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.43085684 |
| 60 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.40899449 |
| 61 | * SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.40390989 |
| 62 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.40325419 |
| 63 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.39830977 |
| 64 | * TP53_22127205_ChIP-Seq_IMR90_Human | 1.39441273 |
| 65 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.38804782 |
| 66 | * ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.38783958 |
| 67 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.38074594 |
| 68 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.36947633 |
| 69 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.36149703 |
| 70 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.35260113 |
| 71 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.35026125 |
| 72 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.32977706 |
| 73 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.28352592 |
| 74 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.28087824 |
| 75 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.27921384 |
| 76 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.27653474 |
| 77 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.27363017 |
| 78 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.26752178 |
| 79 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.26416362 |
| 80 | * SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.26070347 |
| 81 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.25862059 |
| 82 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.25481118 |
| 83 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.25481118 |
| 84 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.24300421 |
| 85 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.24235824 |
| 86 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.23836290 |
| 87 | * KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.23408393 |
| 88 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.23377187 |
| 89 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.22753057 |
| 90 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.22700505 |
| 91 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.19470225 |
| 92 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.18426081 |
| 93 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.18083052 |
| 94 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.17392742 |
| 95 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.17392742 |
| 96 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.17250624 |
| 97 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.16607437 |
| 98 | * SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.15356653 |
| 99 | * NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.15251224 |
| 100 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.14467114 |
| 101 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.13042294 |
| 102 | SA1_22415368_ChIP-Seq_MEFs_Mouse | 1.11968049 |
| 103 | * TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.11657426 |
| 104 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.10012583 |
| 105 | * TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.09079311 |
| 106 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.07492541 |
| 107 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.07272867 |
| 108 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.06208172 |
| 109 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.06145436 |
| 110 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.05512262 |
| 111 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.05251717 |
| 112 | TP53_16413492_ChIP-PET_HCT116_Human | 1.04584274 |
| 113 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.04483423 |
| 114 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.04434379 |
| 115 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.03378222 |
| 116 | * SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.02727271 |
| 117 | KDM2B_26808549_Chip-Seq_K562_Human | 1.02450956 |
| 118 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.01887983 |
| 119 | * TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.01104785 |
| 120 | * NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.00736233 |
| 121 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.99054575 |
| 122 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.97119891 |
| 123 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.96456501 |
| 124 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.96333452 |
| 125 | * HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.94881524 |
| 126 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.93796469 |
| 127 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.92982556 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 6.30123361 |
| 2 | MP0005275_abnormal_skin_tensile | 4.27802078 |
| 3 | MP0003705_abnormal_hypodermis_morpholog | 4.25596443 |
| 4 | MP0004272_abnormal_basement_membrane | 3.42357635 |
| 5 | MP0005623_abnormal_meninges_morphology | 3.16471412 |
| 6 | MP0003279_aneurysm | 3.04887228 |
| 7 | MP0005503_abnormal_tendon_morphology | 2.82595230 |
| 8 | MP0001958_emphysema | 2.81923936 |
| 9 | MP0010030_abnormal_orbit_morphology | 2.69407204 |
| 10 | MP0009384_cardiac_valve_regurgitation | 2.38503235 |
| 11 | MP0003566_abnormal_cell_adhesion | 2.31778129 |
| 12 | MP0010352_gastrointestinal_tract_polyps | 2.31720318 |
| 13 | MP0000537_abnormal_urethra_morphology | 2.02279733 |
| 14 | MP0003283_abnormal_digestive_organ | 1.90431686 |
| 15 | MP0009053_abnormal_anal_canal | 1.87425587 |
| 16 | MP0003091_abnormal_cell_migration | 1.85687249 |
| 17 | MP0003941_abnormal_skin_development | 1.84154621 |
| 18 | MP0005023_abnormal_wound_healing | 1.80837960 |
| 19 | MP0003385_abnormal_body_wall | 1.78671576 |
| 20 | MP0005508_abnormal_skeleton_morphology | 1.70117049 |
| 21 | MP0002060_abnormal_skin_morphology | 1.67293914 |
| 22 | MP0005257_abnormal_intraocular_pressure | 1.60733785 |
| 23 | MP0002295_abnormal_pulmonary_circulatio | 1.60616445 |
| 24 | MP0000733_abnormal_muscle_development | 1.57002503 |
| 25 | MP0006054_spinal_hemorrhage | 1.46545343 |
| 26 | MP0003115_abnormal_respiratory_system | 1.42060849 |
| 27 | MP0002282_abnormal_trachea_morphology | 1.37765432 |
| 28 | MP0009250_abnormal_appendicular_skeleto | 1.36631927 |
| 29 | MP0000013_abnormal_adipose_tissue | 1.36206500 |
| 30 | MP0003942_abnormal_urinary_system | 1.35628922 |
| 31 | MP0009780_abnormal_chondrocyte_physiolo | 1.33868996 |
| 32 | MP0010368_abnormal_lymphatic_system | 1.33676171 |
| 33 | MP0000579_abnormal_nail_morphology | 1.30307740 |
| 34 | MP0000750_abnormal_muscle_regeneration | 1.29707285 |
| 35 | MP0000767_abnormal_smooth_muscle | 1.29624414 |
| 36 | MP0000428_abnormal_craniofacial_morphol | 1.28832564 |
| 37 | MP0005076_abnormal_cell_differentiation | 1.28193383 |
| 38 | MP0004858_abnormal_nervous_system | 1.27560283 |
| 39 | MP0000534_abnormal_ureter_morphology | 1.25624809 |
| 40 | MP0001243_abnormal_dermal_layer | 1.24875950 |
| 41 | MP0005670_abnormal_white_adipose | 1.22026032 |
| 42 | MP0002108_abnormal_muscle_morphology | 1.21243052 |
| 43 | MP0002896_abnormal_bone_mineralization | 1.20330507 |
| 44 | MP0006138_congestive_heart_failure | 1.16801666 |
| 45 | MP0001348_abnormal_lacrimal_gland | 1.16492468 |
| 46 | MP0003755_abnormal_palate_morphology | 1.15764767 |
| 47 | MP0004084_abnormal_cardiac_muscle | 1.15220551 |
| 48 | MP0003937_abnormal_limbs/digits/tail_de | 1.14321350 |
| 49 | MP0005666_abnormal_adipose_tissue | 1.12551797 |
| 50 | MP0004185_abnormal_adipocyte_glucose | 1.11877602 |
| 51 | MP0000003_abnormal_adipose_tissue | 1.11551739 |
| 52 | MP0002932_abnormal_joint_morphology | 1.10986289 |
| 53 | MP0000467_abnormal_esophagus_morphology | 1.10959467 |
| 54 | MP0005197_abnormal_uvea_morphology | 1.10552909 |
| 55 | MP0005375_adipose_tissue_phenotype | 1.09579034 |
| 56 | MP0002697_abnormal_eye_size | 1.08147858 |
| 57 | MP0005595_abnormal_vascular_smooth | 1.06185387 |
| 58 | MP0002234_abnormal_pharynx_morphology | 1.05511512 |
| 59 | MP0001299_abnormal_eye_distance/ | 1.04904161 |
| 60 | MP0002249_abnormal_larynx_morphology | 1.04886238 |
| 61 | MP0002111_abnormal_tail_morphology | 1.04549350 |
| 62 | MP0000762_abnormal_tongue_morphology | 1.03468500 |
| 63 | MP0003119_abnormal_digestive_system | 1.00520536 |
| 64 | MP0003950_abnormal_plasma_membrane | 1.00353124 |
| 65 | MP0004133_heterotaxia | 1.00183822 |
| 66 | MP0000163_abnormal_cartilage_morphology | 0.99088208 |
| 67 | MP0003935_abnormal_craniofacial_develop | 0.98835338 |
| 68 | MP0010234_abnormal_vibrissa_follicle | 0.98391715 |
| 69 | MP0001542_abnormal_bone_strength | 0.98310681 |
| 70 | MP0004197_abnormal_fetal_growth/weight/ | 0.97269272 |
| 71 | MP0002168_other_aberrant_phenotype | 0.93050164 |
| 72 | MP0001614_abnormal_blood_vessel | 0.92982267 |
| 73 | MP0002128_abnormal_blood_circulation | 0.92931467 |
| 74 | MP0004087_abnormal_muscle_fiber | 0.92596795 |
| 75 | MP0002925_abnormal_cardiovascular_devel | 0.91978635 |
| 76 | MP0002233_abnormal_nose_morphology | 0.91440528 |
| 77 | MP0000432_abnormal_head_morphology | 0.91377805 |
| 78 | MP0000749_muscle_degeneration | 0.91314786 |
| 79 | MP0002796_impaired_skin_barrier | 0.91136659 |
| 80 | MP0001879_abnormal_lymphatic_vessel | 0.90536352 |
| 81 | MP0001915_intracranial_hemorrhage | 0.86881401 |
| 82 | MP0004233_abnormal_muscle_weight | 0.86379808 |
| 83 | MP0000049_abnormal_middle_ear | 0.85849024 |
| 84 | MP0010630_abnormal_cardiac_muscle | 0.85113536 |
| 85 | MP0002092_abnormal_eye_morphology | 0.84902868 |
| 86 | MP0002084_abnormal_developmental_patter | 0.82440409 |
| 87 | MP0005501_abnormal_skin_physiology | 0.81911270 |
| 88 | MP0000751_myopathy | 0.81291288 |
| 89 | MP0002116_abnormal_craniofacial_bone | 0.80413402 |
| 90 | MP0005171_absent_coat_pigmentation | 0.79341968 |
| 91 | MP0005423_abnormal_somatic_nervous | 0.78383978 |
| 92 | MP0001340_abnormal_eyelid_morphology | 0.78216447 |
| 93 | MP0002115_abnormal_skeleton_extremities | 0.78085043 |
| 94 | MP0002877_abnormal_melanocyte_morpholog | 0.77863932 |
| 95 | MP0002085_abnormal_embryonic_tissue | 0.77761792 |
| 96 | MP0002114_abnormal_axial_skeleton | 0.77000235 |
| 97 | MP0000462_abnormal_digestive_system | 0.76720910 |
| 98 | MP0003984_embryonic_growth_retardation | 0.75770350 |
| 99 | MP0002088_abnormal_embryonic_growth/wei | 0.74981110 |
| 100 | MP0000759_abnormal_skeletal_muscle | 0.73541019 |
| 101 | MP0005330_cardiomyopathy | 0.73246172 |
| 102 | MP0004134_abnormal_chest_morphology | 0.73243364 |
| 103 | MP0001286_abnormal_eye_development | 0.72772939 |
| 104 | MP0002113_abnormal_skeleton_development | 0.72451625 |
| 105 | MP0001672_abnormal_embryogenesis/_devel | 0.71761668 |
| 106 | MP0005380_embryogenesis_phenotype | 0.71761668 |
| 107 | MP0002089_abnormal_postnatal_growth/wei | 0.70906495 |
| 108 | MP0005193_abnormal_anterior_eye | 0.70587996 |
| 109 | MP0005390_skeleton_phenotype | 0.70526793 |
| 110 | MP0000566_synostosis | 0.70434907 |
| 111 | MP0001849_ear_inflammation | 0.69605144 |
| 112 | MP0000516_abnormal_urinary_system | 0.69571606 |
| 113 | MP0002177_abnormal_outer_ear | 0.67428005 |
| 114 | MP0003890_abnormal_embryonic-extraembry | 0.67300769 |
| 115 | MP0010771_integument_phenotype | 0.65093016 |
| 116 | MP0000778_abnormal_nervous_system | 0.64596888 |
| 117 | MP0002098_abnormal_vibrissa_morphology | 0.62234739 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Premature rupture of membranes (HP:0001788) | 7.40319159 |
| 2 | Protrusio acetabuli (HP:0003179) | 7.19604086 |
| 3 | Shallow orbits (HP:0000586) | 4.82193940 |
| 4 | Ankle contracture (HP:0006466) | 4.18828605 |
| 5 | Atrophic scars (HP:0001075) | 4.15735112 |
| 6 | Peritonitis (HP:0002586) | 4.00601174 |
| 7 | Aortic dissection (HP:0002647) | 3.99469935 |
| 8 | Cerebral aneurysm (HP:0004944) | 3.92809361 |
| 9 | Soft skin (HP:0000977) | 3.80788179 |
| 10 | Bladder diverticulum (HP:0000015) | 3.49399562 |
| 11 | Abnormality of dentin (HP:0010299) | 3.47406355 |
| 12 | Broad metatarsal (HP:0001783) | 3.46846400 |
| 13 | Increased connective tissue (HP:0009025) | 3.43994636 |
| 14 | Fragile skin (HP:0001030) | 3.43759106 |
| 15 | Spinal rigidity (HP:0003306) | 3.34472918 |
| 16 | Dilatation of the ascending aorta (HP:0005111) | 3.32212534 |
| 17 | Aortic aneurysm (HP:0004942) | 3.28691353 |
| 18 | Neonatal short-limb short stature (HP:0008921) | 3.28466613 |
| 19 | Wrist flexion contracture (HP:0001239) | 3.21543885 |
| 20 | Cervical subluxation (HP:0003308) | 3.11477011 |
| 21 | Genu recurvatum (HP:0002816) | 3.01393139 |
| 22 | Wormian bones (HP:0002645) | 2.96141826 |
| 23 | Mitral valve prolapse (HP:0001634) | 2.93319971 |
| 24 | Blue sclerae (HP:0000592) | 2.92821821 |
| 25 | Aplasia of the musculature (HP:0100854) | 2.80837095 |
| 26 | Type 1 muscle fiber predominance (HP:0003803) | 2.75954504 |
| 27 | Short nail (HP:0001799) | 2.69578284 |
| 28 | Bowel diverticulosis (HP:0005222) | 2.64107537 |
| 29 | Distal lower limb muscle weakness (HP:0009053) | 2.62054741 |
| 30 | Difficulty climbing stairs (HP:0003551) | 2.56818897 |
| 31 | Coronal craniosynostosis (HP:0004440) | 2.55881192 |
| 32 | Hip contracture (HP:0003273) | 2.50926789 |
| 33 | Muscle fiber splitting (HP:0003555) | 2.50723138 |
| 34 | Biconcave vertebral bodies (HP:0004586) | 2.49929214 |
| 35 | Buphthalmos (HP:0000557) | 2.46610836 |
| 36 | Right ventricular cardiomyopathy (HP:0011663) | 2.43490578 |
| 37 | Ulnar bowing (HP:0003031) | 2.42976735 |
| 38 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.39109001 |
| 39 | Aneurysm (HP:0002617) | 2.38482178 |
| 40 | Hyperextensible skin (HP:0000974) | 2.35385263 |
| 41 | Infantile muscular hypotonia (HP:0008947) | 2.35320737 |
| 42 | Vertebral compression fractures (HP:0002953) | 2.34713351 |
| 43 | Camptodactyly of toe (HP:0001836) | 2.33138658 |
| 44 | Abnormal delivery (HP:0001787) | 2.32851874 |
| 45 | Wide anterior fontanel (HP:0000260) | 2.32380474 |
| 46 | Limited hip movement (HP:0008800) | 2.29562843 |
| 47 | Stridor (HP:0010307) | 2.26728494 |
| 48 | Achilles tendon contracture (HP:0001771) | 2.26240768 |
| 49 | Limb-girdle muscle atrophy (HP:0003797) | 2.25233273 |
| 50 | Follicular hyperkeratosis (HP:0007502) | 2.25160225 |
| 51 | Distal upper limb amyotrophy (HP:0007149) | 2.24962838 |
| 52 | Upper limb amyotrophy (HP:0009129) | 2.24962838 |
| 53 | Natal tooth (HP:0000695) | 2.22204631 |
| 54 | Deviation of the hallux (HP:0010051) | 2.21826605 |
| 55 | Overgrowth (HP:0001548) | 2.21705570 |
| 56 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.18751125 |
| 57 | Abnormality of the calcaneus (HP:0008364) | 2.18289262 |
| 58 | Hallux valgus (HP:0001822) | 2.17439293 |
| 59 | Vascular tortuosity (HP:0004948) | 2.15934989 |
| 60 | Tibial bowing (HP:0002982) | 2.15749626 |
| 61 | Increased variability in muscle fiber diameter (HP:0003557) | 2.15014656 |
| 62 | Abnormality of carpal bone ossification (HP:0006257) | 2.14897606 |
| 63 | Obstructive sleep apnea (HP:0002870) | 2.14829854 |
| 64 | Round ear (HP:0100830) | 2.14815266 |
| 65 | Elbow flexion contracture (HP:0002987) | 2.14037427 |
| 66 | Bowing of the arm (HP:0006488) | 2.11151775 |
| 67 | Bowed forearm bones (HP:0003956) | 2.11151775 |
| 68 | Abnormal ossification of hand bones (HP:0005921) | 2.08903701 |
| 69 | Scapular winging (HP:0003691) | 2.08458446 |
| 70 | Radial bowing (HP:0002986) | 2.08227328 |
| 71 | Flat acetabular roof (HP:0003180) | 2.08205220 |
| 72 | Bronchomalacia (HP:0002780) | 2.06729612 |
| 73 | Abnormality of the phalanges of the hallux (HP:0010057) | 2.05438776 |
| 74 | Ectopia lentis (HP:0001083) | 2.05145268 |
| 75 | Abnormality of the acetabulum (HP:0003170) | 2.05118701 |
| 76 | Fused cervical vertebrae (HP:0002949) | 2.03658529 |
| 77 | Mesomelia (HP:0003027) | 2.02550350 |
| 78 | Aortic regurgitation (HP:0001659) | 2.02546352 |
| 79 | Knee flexion contracture (HP:0006380) | 2.02511672 |
| 80 | Congenital glaucoma (HP:0001087) | 2.00567048 |
| 81 | Hyperacusis (HP:0010780) | 2.00124028 |
| 82 | Abnormality of the peritoneum (HP:0002585) | 1.99483875 |
| 83 | Short 4th metacarpal (HP:0010044) | 1.98823554 |
| 84 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.98823554 |
| 85 | Spinal cord compression (HP:0002176) | 1.98208253 |
| 86 | Broad face (HP:0000283) | 1.96408545 |
| 87 | Breech presentation (HP:0001623) | 1.96376454 |
| 88 | Bell-shaped thorax (HP:0001591) | 1.96077454 |
| 89 | Osteolytic defects of the hand bones (HP:0009699) | 1.94490718 |
| 90 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.94490718 |
| 91 | Abnormality of the Achilles tendon (HP:0005109) | 1.93769597 |
| 92 | Joint laxity (HP:0001388) | 1.93685836 |
| 93 | Hyporeflexia of lower limbs (HP:0002600) | 1.93316456 |
| 94 | Disproportionate tall stature (HP:0001519) | 1.90556447 |
| 95 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.87732937 |
| 96 | Selective tooth agenesis (HP:0001592) | 1.86517592 |
| 97 | Lymphangioma (HP:0100764) | 1.85254711 |
| 98 | Difficulty running (HP:0009046) | 1.83330120 |
| 99 | Hypoventilation (HP:0002791) | 1.81320134 |
| 100 | Abnormality of the 4th metacarpal (HP:0010012) | 1.80840515 |
| 101 | Venous abnormality (HP:0002624) | 1.80623454 |
| 102 | Renal duplication (HP:0000075) | 1.80560265 |
| 103 | Turricephaly (HP:0000262) | 1.80431553 |
| 104 | Distal lower limb amyotrophy (HP:0008944) | 1.78478911 |
| 105 | Abnormality of the anterior chamber (HP:0000593) | 1.78192240 |
| 106 | Tarsal synostosis (HP:0008368) | 1.77746064 |
| 107 | Coxa vara (HP:0002812) | 1.77654161 |
| 108 | Flexion contracture of toe (HP:0005830) | 1.77087789 |
| 109 | Joint contractures involving the joints of the feet (HP:0100492) | 1.77087789 |
| 110 | Hypoplasia of the iris (HP:0007676) | 1.77007385 |
| 111 | Mitral regurgitation (HP:0001653) | 1.76150080 |
| 112 | Down-sloping shoulders (HP:0200021) | 1.75452951 |
| 113 | Arterial tortuosity (HP:0005116) | 1.75151883 |
| 114 | Thin bony cortex (HP:0002753) | 1.74858294 |
| 115 | Missing ribs (HP:0000921) | 1.74432253 |
| 116 | Abnormal vertebral ossification (HP:0100569) | 1.73759417 |
| 117 | Morphological abnormality of the middle ear (HP:0008609) | 1.73181223 |
| 118 | Broad long bones (HP:0005622) | 1.73132774 |
| 119 | Limb-girdle muscle weakness (HP:0003325) | 1.73057670 |
| 120 | Partial duplication of the phalanx of hand (HP:0009999) | 1.72821927 |
| 121 | Thin ribs (HP:0000883) | 1.71258897 |
| 122 | Mitral stenosis (HP:0001718) | 1.70831272 |
| 123 | Lower limb amyotrophy (HP:0007210) | 1.70714818 |
| 124 | Acanthosis nigricans (HP:0000956) | 1.70473363 |
| 125 | Venous insufficiency (HP:0005293) | 1.70010314 |
| 126 | Aplasia involving bones of the extremities (HP:0009825) | 1.69808349 |
| 127 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.69808349 |
| 128 | Aplasia of the phalanges of the hand (HP:0009802) | 1.69808349 |
| 129 | Abnormality of the middle phalanges of the toes (HP:0010183) | 1.69541969 |
| 130 | Hand muscle atrophy (HP:0009130) | 1.69216939 |
| 131 | Increased density of long bones (HP:0006392) | 1.68728389 |
| 132 | Aortic valve stenosis (HP:0001650) | 1.67969884 |
| 133 | Abnormal hand bone ossification (HP:0010660) | 1.66414155 |
| 134 | Slender build (HP:0001533) | 1.65263091 |
| 135 | Advanced eruption of teeth (HP:0006288) | 1.63185409 |
| 136 | Abnormality of the odontoid process (HP:0003310) | 1.63178317 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TTN | 4.43289374 |
| 2 | EPHA2 | 3.73388537 |
| 3 | TRIB3 | 3.64253498 |
| 4 | DDR2 | 3.41482768 |
| 5 | LATS2 | 3.25938351 |
| 6 | EPHB2 | 3.24373046 |
| 7 | PDGFRA | 3.07745700 |
| 8 | LATS1 | 2.79092422 |
| 9 | PKN2 | 2.14368542 |
| 10 | RIPK1 | 2.11053053 |
| 11 | SIK1 | 2.08972149 |
| 12 | PAK2 | 2.05454219 |
| 13 | PTK2 | 1.90633477 |
| 14 | FER | 1.89345119 |
| 15 | PAK4 | 1.87296502 |
| 16 | MARK1 | 1.75961423 |
| 17 | MST1R | 1.73123332 |
| 18 | PAK3 | 1.68354178 |
| 19 | ERN1 | 1.61144728 |
| 20 | BMX | 1.56403936 |
| 21 | MET | 1.52278126 |
| 22 | AKT3 | 1.49614561 |
| 23 | PTK6 | 1.48252600 |
| 24 | STK38 | 1.47174492 |
| 25 | MTOR | 1.42857586 |
| 26 | FGFR1 | 1.37862882 |
| 27 | MAP3K9 | 1.37600066 |
| 28 | LIMK1 | 1.37458390 |
| 29 | DMPK | 1.31060948 |
| 30 | STK38L | 1.29360684 |
| 31 | TESK1 | 1.28041975 |
| 32 | PIM2 | 1.22907623 |
| 33 | TRPM7 | 1.20617041 |
| 34 | FGFR2 | 1.20504241 |
| 35 | CDK12 | 1.17481687 |
| 36 | CAMK1D | 1.16877582 |
| 37 | EEF2K | 1.08226800 |
| 38 | SMG1 | 1.07900973 |
| 39 | LRRK2 | 1.07659319 |
| 40 | FLT3 | 1.07537976 |
| 41 | ICK | 1.05007879 |
| 42 | ROCK1 | 1.04583691 |
| 43 | ILK | 1.04340691 |
| 44 | MAP3K6 | 1.03459760 |
| 45 | RPS6KB2 | 1.03198267 |
| 46 | MAP3K7 | 1.00341583 |
| 47 | RPS6KA4 | 0.99997399 |
| 48 | PDGFRB | 0.95793091 |
| 49 | TIE1 | 0.95699248 |
| 50 | MAP3K10 | 0.95183836 |
| 51 | STK3 | 0.94704263 |
| 52 | MYLK | 0.89601240 |
| 53 | MAP2K1 | 0.86236550 |
| 54 | PIK3CA | 0.85136041 |
| 55 | RPS6KA2 | 0.83330706 |
| 56 | CAMK1G | 0.80985721 |
| 57 | MAPKAPK3 | 0.78896720 |
| 58 | CDK8 | 0.78260157 |
| 59 | ROCK2 | 0.78082959 |
| 60 | MAP3K3 | 0.77417304 |
| 61 | KDR | 0.77254232 |
| 62 | TGFBR1 | 0.76207326 |
| 63 | PTK2B | 0.75838074 |
| 64 | TGFBR2 | 0.74994101 |
| 65 | TYRO3 | 0.74681431 |
| 66 | PRKD1 | 0.72362782 |
| 67 | MOS | 0.72120588 |
| 68 | MAP3K8 | 0.71192537 |
| 69 | CLK1 | 0.69914094 |
| 70 | ERBB4 | 0.67594588 |
| 71 | PAK1 | 0.67246507 |
| 72 | CAMK2G | 0.65353089 |
| 73 | TESK2 | 0.65265112 |
| 74 | DAPK3 | 0.64635855 |
| 75 | STK10 | 0.59286795 |
| 76 | CDK6 | 0.58729033 |
| 77 | INSR | 0.57925737 |
| 78 | BUB1 | 0.57804058 |
| 79 | BRSK1 | 0.57473325 |
| 80 | BRD4 | 0.57189947 |
| 81 | CAMK2B | 0.57163716 |
| 82 | PRKD3 | 0.55688290 |
| 83 | AKT2 | 0.55402727 |
| 84 | EPHB1 | 0.54377070 |
| 85 | FGFR4 | 0.53851494 |
| 86 | NEK1 | 0.52864400 |
| 87 | NEK9 | 0.52853761 |
| 88 | CDC42BPA | 0.52317689 |
| 89 | MELK | 0.50879203 |
| 90 | BCR | 0.50285201 |
| 91 | PDK3 | 0.50149224 |
| 92 | PDK4 | 0.50149224 |
| 93 | TTK | 0.50091518 |
| 94 | PDK2 | 0.49460602 |
| 95 | GSK3A | 0.49387662 |
| 96 | ERBB2 | 0.49317974 |
| 97 | MARK2 | 0.48679879 |
| 98 | CDK7 | 0.46779230 |
| 99 | ARAF | 0.46640455 |
| 100 | PRKD2 | 0.45221129 |
| 101 | PRKG2 | 0.45058523 |
| 102 | CDK9 | 0.44521207 |
| 103 | LMTK2 | 0.42757887 |
| 104 | MAP2K2 | 0.42065786 |
| 105 | RPS6KC1 | 0.41344371 |
| 106 | RPS6KL1 | 0.41344371 |
| 107 | NTRK1 | 0.37987706 |
| 108 | ADRBK1 | 0.37001035 |
| 109 | SRC | 0.36443163 |
| 110 | DYRK1B | 0.35408231 |
| 111 | PIK3CG | 0.35147631 |
| 112 | MUSK | 0.34636247 |
| 113 | AURKA | 0.34338899 |
| 114 | ERBB3 | 0.34107417 |
| 115 | WEE1 | 0.33840761 |
| 116 | PRKAA1 | 0.33682743 |
| 117 | ABL2 | 0.33491321 |
| 118 | KSR1 | 0.32901947 |
| 119 | PAK6 | 0.32822435 |
| 120 | PNCK | 0.32430814 |
| 121 | AURKB | 0.32176369 |
| 122 | NEK2 | 0.31977405 |
| 123 | CAMK2D | 0.30625365 |
| 124 | CDK15 | 0.30015990 |
| 125 | MAPK1 | 0.28757603 |
| 126 | CDK18 | 0.28570400 |
| 127 | BCKDK | 0.27828554 |
| 128 | CDK11A | 0.27821659 |
| 129 | RAF1 | 0.27340218 |
| 130 | PRKCI | 0.26925631 |
| 131 | ALK | 0.26444936 |
| 132 | MAPKAPK2 | 0.26217443 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ECM-receptor interaction_Homo sapiens_hsa04512 | 4.26893885 |
| 2 | Focal adhesion_Homo sapiens_hsa04510 | 3.13044900 |
| 3 | Hippo signaling pathway_Homo sapiens_hsa04390 | 2.78143860 |
| 4 | Basal cell carcinoma_Homo sapiens_hsa05217 | 2.66490462 |
| 5 | Adherens junction_Homo sapiens_hsa04520 | 2.55759704 |
| 6 | Bladder cancer_Homo sapiens_hsa05219 | 2.44388807 |
| 7 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.40616436 |
| 8 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 2.37131089 |
| 9 | Small cell lung cancer_Homo sapiens_hsa05222 | 2.30831910 |
| 10 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 2.10106571 |
| 11 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 2.07309675 |
| 12 | Amoebiasis_Homo sapiens_hsa05146 | 2.02954032 |
| 13 | Tight junction_Homo sapiens_hsa04530 | 2.00316637 |
| 14 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.99191615 |
| 15 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.99002838 |
| 16 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.95781450 |
| 17 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.94133166 |
| 18 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.89823792 |
| 19 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.71732202 |
| 20 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.69547047 |
| 21 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.62929349 |
| 22 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.62040569 |
| 23 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.51016740 |
| 24 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 1.38443546 |
| 25 | Melanoma_Homo sapiens_hsa05218 | 1.35259188 |
| 26 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.32701906 |
| 27 | Axon guidance_Homo sapiens_hsa04360 | 1.31744007 |
| 28 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.26028212 |
| 29 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.22326260 |
| 30 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.21609806 |
| 31 | Pathways in cancer_Homo sapiens_hsa05200 | 1.20508381 |
| 32 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.19342337 |
| 33 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.19040146 |
| 34 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.18640017 |
| 35 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.15460221 |
| 36 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.13770325 |
| 37 | Viral myocarditis_Homo sapiens_hsa05416 | 1.11757596 |
| 38 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 1.07355243 |
| 39 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.06102151 |
| 40 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.05457355 |
| 41 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.03516127 |
| 42 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.96496819 |
| 43 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.95992161 |
| 44 | Prostate cancer_Homo sapiens_hsa05215 | 0.95936452 |
| 45 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.93976190 |
| 46 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.88388929 |
| 47 | HTLV-I infection_Homo sapiens_hsa05166 | 0.88289844 |
| 48 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.88119095 |
| 49 | Malaria_Homo sapiens_hsa05144 | 0.85621887 |
| 50 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.85139020 |
| 51 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.82899166 |
| 52 | Lysine degradation_Homo sapiens_hsa00310 | 0.81945074 |
| 53 | Melanogenesis_Homo sapiens_hsa04916 | 0.81806553 |
| 54 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.81792643 |
| 55 | Sulfur relay system_Homo sapiens_hsa04122 | 0.79801519 |
| 56 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.76818112 |
| 57 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.76260392 |
| 58 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.75207326 |
| 59 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.74739324 |
| 60 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.71726113 |
| 61 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.70006250 |
| 62 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.68490363 |
| 63 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.67873880 |
| 64 | Carbon metabolism_Homo sapiens_hsa01200 | 0.66576919 |
| 65 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.66419554 |
| 66 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.65628756 |
| 67 | Circadian rhythm_Homo sapiens_hsa04710 | 0.64825560 |
| 68 | Endometrial cancer_Homo sapiens_hsa05213 | 0.64525127 |
| 69 | Glioma_Homo sapiens_hsa05214 | 0.63746450 |
| 70 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.63459462 |
| 71 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.62903891 |
| 72 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.62342685 |
| 73 | Shigellosis_Homo sapiens_hsa05131 | 0.62234408 |
| 74 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.62134016 |
| 75 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.61635597 |
| 76 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.60939670 |
| 77 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.60452020 |
| 78 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.60352821 |
| 79 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.60304298 |
| 80 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.59400271 |
| 81 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.59319970 |
| 82 | Gap junction_Homo sapiens_hsa04540 | 0.59166665 |
| 83 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.59046306 |
| 84 | Cell cycle_Homo sapiens_hsa04110 | 0.58885186 |
| 85 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.58015405 |
| 86 | Insulin resistance_Homo sapiens_hsa04931 | 0.57207969 |
| 87 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.56092123 |
| 88 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.54580109 |
| 89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.52932718 |
| 90 | Cocaine addiction_Homo sapiens_hsa05030 | 0.52142708 |
| 91 | Colorectal cancer_Homo sapiens_hsa05210 | 0.50738783 |
| 92 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.50537113 |
| 93 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.49921560 |
| 94 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.49892995 |
| 95 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.49252807 |
| 96 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.48596155 |
| 97 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.48391744 |
| 98 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.48008149 |
| 99 | Prion diseases_Homo sapiens_hsa05020 | 0.46281973 |
| 100 | Platelet activation_Homo sapiens_hsa04611 | 0.46026837 |
| 101 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.45902582 |
| 102 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.45714204 |
| 103 | Bile secretion_Homo sapiens_hsa04976 | 0.45279939 |
| 104 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.44837031 |
| 105 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.44240205 |
| 106 | Thyroid cancer_Homo sapiens_hsa05216 | 0.43748574 |
| 107 | Galactose metabolism_Homo sapiens_hsa00052 | 0.43350970 |
| 108 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.43178863 |
| 109 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.42823478 |
| 110 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.42088882 |
| 111 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.41957510 |
| 112 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.41929245 |
| 113 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.41710547 |
| 114 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.40493645 |
| 115 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.38924592 |
| 116 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.38691267 |
| 117 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.38141625 |
| 118 | Apoptosis_Homo sapiens_hsa04210 | 0.38118740 |
| 119 | Endocytosis_Homo sapiens_hsa04144 | 0.37959803 |
| 120 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.37886649 |
| 121 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.37768307 |
| 122 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.37058086 |
| 123 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.36984686 |
| 124 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.36804108 |
| 125 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.35765161 |
| 126 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.34964060 |
| 127 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.34951500 |
| 128 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.33576793 |
| 129 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.33233617 |
| 130 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.32490714 |
| 131 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.32233778 |
| 132 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.32115812 |
| 133 | RNA transport_Homo sapiens_hsa03013 | 0.31858083 |

