AMPD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.29516073
2Golgi transport vesicle coating (GO:0048200)8.29516073
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.75969653
4negative regulation of cell killing (GO:0031342)5.75969653
5positive regulation of gamma-delta T cell activation (GO:0046645)5.60989823
6positive regulation by symbiont of host defense response (GO:0052509)5.45224211
7modulation by symbiont of host defense response (GO:0052031)5.45224211
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.45224211
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.45224211
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.45224211
11modulation by symbiont of host immune response (GO:0052553)5.45224211
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.42142702
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.15373807
14response to peptidoglycan (GO:0032494)5.15132640
15neutrophil activation involved in immune response (GO:0002283)5.12290312
16protein retention in ER lumen (GO:0006621)4.99230307
17activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.94823383
18folic acid-containing compound biosynthetic process (GO:0009396)4.89627948
19positive regulation of nuclease activity (GO:0032075)4.87942942
20antigen processing and presentation of endogenous antigen (GO:0019883)4.78703477
21protein maturation by protein folding (GO:0022417)4.77984810
22detection of other organism (GO:0098543)4.65389061
23macrophage activation involved in immune response (GO:0002281)4.55134241
24cellular extravasation (GO:0045123)4.51250195
25regulation of nuclease activity (GO:0032069)4.44306591
26detection of bacterium (GO:0016045)4.43925029
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.41526324
28regulation of translational fidelity (GO:0006450)4.31441406
29L-alpha-amino acid transmembrane transport (GO:1902475)4.26586473
30leukocyte aggregation (GO:0070486)4.23661595
31detection of molecule of bacterial origin (GO:0032490)4.22557111
32negative regulation of erythrocyte differentiation (GO:0045647)4.15703962
33endoplasmic reticulum unfolded protein response (GO:0030968)4.10946926
34detection of external biotic stimulus (GO:0098581)4.10611017
35regulation of mast cell degranulation (GO:0043304)4.10503438
36regulation of B cell receptor signaling pathway (GO:0050855)4.02963492
37cellular response to unfolded protein (GO:0034620)3.92944640
38regulation of gamma-delta T cell activation (GO:0046643)3.92019517
39regulation of myeloid leukocyte mediated immunity (GO:0002886)3.90178727
40response to muramyl dipeptide (GO:0032495)3.86967816
41DNA unwinding involved in DNA replication (GO:0006268)3.86507869
42regulation of leukocyte degranulation (GO:0043300)3.85662107
43response to host immune response (GO:0052572)3.84942987
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.84942987
45negative regulation of interleukin-12 production (GO:0032695)3.84107010
46cellular response to topologically incorrect protein (GO:0035967)3.81376348
47neutrophil activation (GO:0042119)3.80899987
48vesicle coating (GO:0006901)3.77897736
49regulation of mast cell activation involved in immune response (GO:0033006)3.72420472
50detection of biotic stimulus (GO:0009595)3.70665803
51negative regulation of lymphocyte mediated immunity (GO:0002707)3.70477080
52leukocyte migration involved in inflammatory response (GO:0002523)3.70144079
53ER-nucleus signaling pathway (GO:0006984)3.69622846
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.65644256
55response to host (GO:0075136)3.65644256
56response to host defenses (GO:0052200)3.65644256
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.64697443
58respiratory burst (GO:0045730)3.60974496
59exocrine pancreas development (GO:0031017)3.60275441
60positive regulation of mast cell activation (GO:0033005)3.57710765
61COPII vesicle coating (GO:0048208)3.55516000
62positive regulation of histone deacetylation (GO:0031065)3.51354652
63regulation of interferon-beta biosynthetic process (GO:0045357)3.47881306
64regulation of translational termination (GO:0006449)3.46719265
65positive regulation of B cell differentiation (GO:0045579)3.46600018
66macrophage activation (GO:0042116)3.45256344
67negative regulation of leukocyte mediated immunity (GO:0002704)3.44807471
68regulation of regulated secretory pathway (GO:1903305)3.44584839
69sodium ion export (GO:0071436)3.44328927
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.44265094
71granulocyte activation (GO:0036230)3.43214477
72regulation of gamma-delta T cell differentiation (GO:0045586)3.42361313
73pentose-phosphate shunt (GO:0006098)3.41709934
74antigen processing and presentation via MHC class Ib (GO:0002475)3.39277422
75myeloid cell activation involved in immune response (GO:0002275)3.39235155
76peptidyl-lysine dimethylation (GO:0018027)3.38103533
77neutrophil mediated immunity (GO:0002446)3.35934278
78oxaloacetate metabolic process (GO:0006107)3.35770071
79pteridine-containing compound biosynthetic process (GO:0042559)3.34398337
80response to interleukin-15 (GO:0070672)3.34386272
81protein autoprocessing (GO:0016540)3.32270871
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30480741
83translesion synthesis (GO:0019985)3.30348565
84peptidyl-arginine omega-N-methylation (GO:0035247)3.23816443
85microglial cell activation (GO:0001774)3.21389156
86regulation of mast cell activation (GO:0033003)3.20871953
87positive regulation of mast cell degranulation (GO:0043306)3.18539453
88positive regulation of mast cell activation involved in immune response (GO:0033008)3.18539453
89nucleobase biosynthetic process (GO:0046112)3.17692007
90regulation of T-helper 2 cell differentiation (GO:0045628)3.15812868
91chaperone mediated protein folding requiring cofactor (GO:0051085)3.15235583
92negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13596537
93regulation of B cell differentiation (GO:0045577)3.11577034
94negative regulation of phagocytosis (GO:0050765)3.10814984
95germinal center formation (GO:0002467)3.09930611
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.09682351
97antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.09682351
98pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.08775837
99UMP biosynthetic process (GO:0006222)3.08775837
100pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.08775837
101UMP metabolic process (GO:0046049)3.08775837
102B cell receptor signaling pathway (GO:0050853)3.05714770
103response to endoplasmic reticulum stress (GO:0034976)3.05037885
104negative regulation of T cell mediated immunity (GO:0002710)3.03644949
105response to pheromone (GO:0019236)3.02965727
106tetrahydrofolate metabolic process (GO:0046653)3.02195412
107immunoglobulin mediated immune response (GO:0016064)2.99616369
108heterochromatin organization (GO:0070828)2.97988889
109negative regulation of RNA splicing (GO:0033119)2.94994492
110positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.94389748
111negative regulation of glycoprotein biosynthetic process (GO:0010561)2.94137888
112dosage compensation (GO:0007549)2.93677468
113leukocyte degranulation (GO:0043299)2.92966562
114positive regulation of cellular amide metabolic process (GO:0034250)2.91596477
115mannose metabolic process (GO:0006013)2.91391266
116positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.91086426
117positive regulation of regulated secretory pathway (GO:1903307)2.91008861
118ribosomal small subunit assembly (GO:0000028)2.90697320
119megakaryocyte development (GO:0035855)2.90219670
120regulation of erythrocyte differentiation (GO:0045646)2.90158291
121negative regulation of interleukin-6 production (GO:0032715)2.90019322
122maternal placenta development (GO:0001893)2.89912094
123positive regulation of protein deacetylation (GO:0090312)2.87942617
124tricarboxylic acid metabolic process (GO:0072350)2.87897477
125glucocorticoid receptor signaling pathway (GO:0042921)2.86576693
126endosome to melanosome transport (GO:0035646)2.86563149
127endosome to pigment granule transport (GO:0043485)2.86563149
128regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.86414066
129lipopolysaccharide-mediated signaling pathway (GO:0031663)2.85995014
130negative regulation of toll-like receptor signaling pathway (GO:0034122)2.85583109
131regulation of macrophage cytokine production (GO:0010935)2.83423905
132response to unfolded protein (GO:0006986)2.83091727
133sequestering of metal ion (GO:0051238)2.80904925
134pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.79354134
135positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.78731503
136positive regulation of insulin secretion (GO:0032024)2.78040408
137negative regulation of mRNA metabolic process (GO:1903312)2.76691663
138response to topologically incorrect protein (GO:0035966)2.76569130
139regulation of ARF protein signal transduction (GO:0032012)2.76476446
140negative regulation of type 2 immune response (GO:0002829)2.76313261
141peptidyl-asparagine modification (GO:0018196)2.76123903
142myeloid leukocyte mediated immunity (GO:0002444)2.75967698
143negative regulation of innate immune response (GO:0045824)2.75730207
144regulation of dendritic cell antigen processing and presentation (GO:0002604)2.74938399
145positive regulation of transcription regulatory region DNA binding (GO:2000679)2.74681713
146protein N-linked glycosylation via asparagine (GO:0018279)2.74649389
147proline biosynthetic process (GO:0006561)2.74628769
148DNA strand elongation involved in DNA replication (GO:0006271)2.73813123
149positive thymic T cell selection (GO:0045059)2.73388657
150DNA strand elongation (GO:0022616)2.72373935
151positive regulation of Rap GTPase activity (GO:0032854)2.69381522
152positive regulation of leukocyte degranulation (GO:0043302)2.69321878
153neutrophil chemotaxis (GO:0030593)2.68381678
154protoporphyrinogen IX metabolic process (GO:0046501)2.67200982
155pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.65900497
1564-hydroxyproline metabolic process (GO:0019471)2.65287222
157defense response to protozoan (GO:0042832)2.64247688
158endocrine pancreas development (GO:0031018)2.64131740
159positive regulation of synapse maturation (GO:0090129)2.64072700
160negative regulation of cytokine production involved in immune response (GO:0002719)2.63652656
161cellular potassium ion homeostasis (GO:0030007)2.63105649
162response to laminar fluid shear stress (GO:0034616)2.63052239
163regulation of ARF GTPase activity (GO:0032312)2.62896266
164negative thymic T cell selection (GO:0045060)2.62105038
165NADPH regeneration (GO:0006740)2.61939578
166neutrophil migration (GO:1990266)2.60773220
167histone H4-K12 acetylation (GO:0043983)2.60590253
168regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.59568018
169regulation of natural killer cell mediated immunity (GO:0002715)2.59568018
170cerebellar Purkinje cell layer development (GO:0021680)2.57921461
171regulation of platelet aggregation (GO:0090330)2.57792372
172platelet formation (GO:0030220)2.57227013
173histone arginine methylation (GO:0034969)2.56448867
174cellular response to interleukin-15 (GO:0071350)2.54714876
175peptidyl-arginine methylation (GO:0018216)2.54678540
176peptidyl-arginine N-methylation (GO:0035246)2.54678540
177DNA replication initiation (GO:0006270)2.54052199
178regulation of cholesterol homeostasis (GO:2000188)2.54035903
179peptide hormone processing (GO:0016486)2.51956362
180regulation of tolerance induction (GO:0002643)2.51560184
181DNA duplex unwinding (GO:0032508)2.51324981
182regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.50614783
183nitric oxide mediated signal transduction (GO:0007263)2.49989127
184positive regulation of triglyceride biosynthetic process (GO:0010867)2.49746017
185protoporphyrinogen IX biosynthetic process (GO:0006782)2.49652488
186nucleosome disassembly (GO:0006337)2.48347732
187protein-DNA complex disassembly (GO:0032986)2.48347732
188negative regulation of cytosolic calcium ion concentration (GO:0051481)2.47786765
189insulin secretion (GO:0030073)2.46213869
190embryonic hemopoiesis (GO:0035162)2.45960117
191DNA geometric change (GO:0032392)2.45147713
192negative regulation of cell size (GO:0045792)2.44547709
193negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.43877103
194protein N-linked glycosylation (GO:0006487)2.42859308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.72499121
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10941818
3MYC_22102868_ChIP-Seq_BL_Human3.73878461
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.56281366
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.22924014
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.11627918
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.91944562
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.60463155
9SCL_19346495_ChIP-Seq_HPC-7_Human2.58122014
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54432723
11VDR_21846776_ChIP-Seq_THP-1_Human2.52480111
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34447701
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32829935
14CIITA_25753668_ChIP-Seq_RAJI_Human2.28806508
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.27178714
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11975872
17TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08703568
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08488110
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.05871265
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01543851
21GATA1_22025678_ChIP-Seq_K562_Human2.00662633
22TCF7_22412390_ChIP-Seq_EML_Mouse1.93699945
23CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.92707387
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.85916648
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82864569
26* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81776685
27MAF_26560356_Chip-Seq_TH2_Human1.81411248
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81100402
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78993571
30XRN2_22483619_ChIP-Seq_HELA_Human1.77461918
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74794536
32CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74575662
33TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.74382795
34* LXR_22292898_ChIP-Seq_THP-1_Human1.74319794
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74177394
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74011016
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70089540
38* KDM2B_26808549_Chip-Seq_JURKAT_Human1.68840757
39RUNX_20019798_ChIP-Seq_JUKART_Human1.68709195
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66843724
41CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.66491426
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65233479
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63744182
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63703112
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63541075
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62471857
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61412755
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.60841853
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59788039
50GABP_19822575_ChIP-Seq_HepG2_Human1.56759476
51KDM2B_26808549_Chip-Seq_K562_Human1.53777055
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53429656
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53243948
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52745122
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.51644404
56KDM2B_26808549_Chip-Seq_DND41_Human1.51491041
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.51170398
58* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49922951
59* UTX_26944678_Chip-Seq_JUKART_Human1.49044908
60RACK7_27058665_Chip-Seq_MCF-7_Human1.47698978
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47221078
62MYB_26560356_Chip-Seq_TH1_Human1.46912086
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.46561519
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46328134
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.46112768
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45436916
67MYB_26560356_Chip-Seq_TH2_Human1.45416576
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44309923
69* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43555048
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43212393
71TFEB_21752829_ChIP-Seq_HELA_Human1.42304825
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.41306054
73FOXP3_21729870_ChIP-Seq_TREG_Human1.40836694
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.39210654
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38368028
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38347037
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37207528
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37043983
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36956734
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36660454
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36118159
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35338882
83KDM5A_27292631_Chip-Seq_BREAST_Human1.35241968
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.34820890
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33993552
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33149316
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33010059
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32458010
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32127691
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30859160
91VDR_24763502_ChIP-Seq_THP-1_Human1.30440056
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29318221
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28751323
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28076920
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27748255
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.27677186
97GATA1_19941826_ChIP-Seq_K562_Human1.26303720
98P68_20966046_ChIP-Seq_HELA_Human1.24921454
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22837081
100MAF_26560356_Chip-Seq_TH1_Human1.22761830
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20633149
102* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20391733
103BCOR_27268052_Chip-Seq_Bcells_Human1.20276627
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19354724
105* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17936788
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17812397
107BCL6_27268052_Chip-Seq_Bcells_Human1.17690909
108KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17596783
109DCP1A_22483619_ChIP-Seq_HELA_Human1.17488598
110NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17300889
111MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17081078
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16063080
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16060948
114RUNX1_22412390_ChIP-Seq_EML_Mouse1.15494884
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15443256
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14923354
117SPI1_23127762_ChIP-Seq_K562_Human1.14884531
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14315183
119NCOR1_26117541_ChIP-Seq_K562_Human1.13994297
120EST1_17652178_ChIP-ChIP_JURKAT_Human1.13736677
121FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12510177
122* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12197434
123SMC4_20622854_ChIP-Seq_HELA_Human1.11088034
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10228560
125GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09786669
126TTF2_22483619_ChIP-Seq_HELA_Human1.09623444
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09419547
128E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08263217
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08016010
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07847559
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07684154
132IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07324440
133LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06300655
134BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06150207
135CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05140403
136VDR_23849224_ChIP-Seq_CD4+_Human1.04954705
137CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04415762
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04096966
139VDR_24787735_ChIP-Seq_THP-1_Human1.04041661
140TET1_21451524_ChIP-Seq_MESCs_Mouse1.04015468
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03961707
142TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03771168
143YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03295549
144PHF8_20622854_ChIP-Seq_HELA_Human1.03212303
145RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01299094
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01179272
147SMAD_19615063_ChIP-ChIP_OVARY_Human1.00644428
148GATA3_27048872_Chip-Seq_THYMUS_Human1.00398271
149PU_27001747_Chip-Seq_BMDM_Mouse1.00273570
150GATA2_21666600_ChIP-Seq_HMVEC_Human1.00161696
151* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00141744
152* CREB1_26743006_Chip-Seq_LNCaP_Human0.98756985
153* SPI1_23547873_ChIP-Seq_NB4_Human0.98265987
154UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98224788
155PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97423021
156KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97222413
157SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95406858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.34535426
2MP0002877_abnormal_melanocyte_morpholog3.46479109
3MP0003123_paternal_imprinting3.38910807
4MP0003283_abnormal_digestive_organ3.16919012
5MP0001835_abnormal_antigen_presentation3.01964125
6MP0002419_abnormal_innate_immunity3.01815377
7MP0003172_abnormal_lysosome_physiology2.90985539
8MP0003183_abnormal_peptide_metabolism2.78794185
9MP0005220_abnormal_exocrine_pancreas2.75559003
10MP0003122_maternal_imprinting2.68305566
11MP0002909_abnormal_adrenal_gland2.66671399
12MP0010352_gastrointestinal_tract_polyps2.64697345
13MP0005025_abnormal_response_to2.53848097
14MP0008260_abnormal_autophagy2.53113861
15MP0005000_abnormal_immune_tolerance2.41539499
16MP0001944_abnormal_pancreas_morphology2.40606886
17MP0002396_abnormal_hematopoietic_system2.34568064
18MP0004808_abnormal_hematopoietic_stem2.33383228
19MP0002693_abnormal_pancreas_physiology2.29990321
20MP0001800_abnormal_humoral_immune2.27561662
21MP0003191_abnormal_cellular_cholesterol2.26116938
22MP0001533_abnormal_skeleton_physiology2.22698905
23MP0003300_gastrointestinal_ulcer2.19801809
24MP0002132_abnormal_respiratory_system2.18845501
25MP0002420_abnormal_adaptive_immunity2.17844549
26MP0002723_abnormal_immune_serum2.16196034
27MP0001819_abnormal_immune_cell2.15473399
28MP0005387_immune_system_phenotype2.12953574
29MP0001790_abnormal_immune_system2.12953574
30MP0008961_abnormal_basal_metabolism2.06731322
31MP0002452_abnormal_antigen_presenting2.04645067
32MP0006082_CNS_inflammation2.04542333
33MP0001545_abnormal_hematopoietic_system2.03937542
34MP0005397_hematopoietic_system_phenotyp2.03937542
35MP0009780_abnormal_chondrocyte_physiolo2.00904603
36MP0005451_abnormal_body_composition1.93122571
37MP0009785_altered_susceptibility_to1.86571621
38MP0005671_abnormal_response_to1.86147754
39MP0004264_abnormal_extraembryonic_tissu1.85762810
40MP0005464_abnormal_platelet_physiology1.81182802
41MP0003121_genomic_imprinting1.81151621
42MP0000013_abnormal_adipose_tissue1.80579591
43MP0003763_abnormal_thymus_physiology1.80561932
44MP0004947_skin_inflammation1.80467414
45MP0003693_abnormal_embryo_hatching1.76522369
46MP0010307_abnormal_tumor_latency1.71350247
47MP0003828_pulmonary_edema1.70481745
48MP0003111_abnormal_nucleus_morphology1.69458011
49MP0006054_spinal_hemorrhage1.68339900
50MP0003866_abnormal_defecation1.66705060
51MP0002148_abnormal_hypersensitivity_rea1.66134297
52MP0003868_abnormal_feces_composition1.66132060
53MP0000716_abnormal_immune_system1.64352906
54MP0002405_respiratory_system_inflammati1.62372315
55MP0003656_abnormal_erythrocyte_physiolo1.60834579
56MP0000678_abnormal_parathyroid_gland1.58403609
57MP0010094_abnormal_chromosome_stability1.57009086
58MP0000858_altered_metastatic_potential1.48854223
59MP0003075_altered_response_to1.48851299
60MP0004510_myositis1.48103153
61MP0003705_abnormal_hypodermis_morpholog1.43147214
62MP0002078_abnormal_glucose_homeostasis1.42675583
63MP0000003_abnormal_adipose_tissue1.41812332
64MP0002998_abnormal_bone_remodeling1.41402807
65MP0004957_abnormal_blastocyst_morpholog1.40310885
66MP0001845_abnormal_inflammatory_respons1.38922012
67MP0006072_abnormal_retinal_apoptosis1.37616066
68MP0009672_abnormal_birth_weight1.36880691
69MP0000465_gastrointestinal_hemorrhage1.36142581
70MP0002089_abnormal_postnatal_growth/wei1.35763409
71MP0001851_eye_inflammation1.35672324
72MP0005083_abnormal_biliary_tract1.35332129
73MP0009278_abnormal_bone_marrow1.33229653
74MP0010155_abnormal_intestine_physiology1.32549118
75MP0009840_abnormal_foam_cell1.32435841
76MP0005076_abnormal_cell_differentiation1.31921946
77MP0008469_abnormal_protein_level1.27954745
78MP0009333_abnormal_splenocyte_physiolog1.26189689
79MP0001730_embryonic_growth_arrest1.25783246
80MP0004043_abnormal_pH_regulation1.21406393
81MP0003943_abnormal_hepatobiliary_system1.19706968
82MP0000358_abnormal_cell_content/1.19666348
83MP0003077_abnormal_cell_cycle1.18392572
84MP0005365_abnormal_bile_salt1.17985878
85MP0002234_abnormal_pharynx_morphology1.17038291
86MP0004858_abnormal_nervous_system1.16778506
87MP0002928_abnormal_bile_duct1.15418599
88MP0008007_abnormal_cellular_replicative1.14279449
89MP0003329_amyloid_beta_deposits1.13294472
90MP0003303_peritoneal_inflammation1.12292258
91MP0003959_abnormal_lean_body1.11480370
92MP0000490_abnormal_crypts_of1.10922145
93MP0003690_abnormal_glial_cell1.10836794
94MP0004883_abnormal_blood_vessel1.09447901
95MP0005390_skeleton_phenotype1.09425081
96MP0005379_endocrine/exocrine_gland_phen1.08331101
97MP0008004_abnormal_stomach_pH1.07659993
98MP0000604_amyloidosis1.07478839
99MP0004859_abnormal_synaptic_plasticity1.07442729
100MP0009764_decreased_sensitivity_to1.05932609
101MP0005164_abnormal_response_to1.05562802
102MP0005058_abnormal_lysosome_morphology1.03955756
103MP0000639_abnormal_adrenal_gland1.03759493
104MP0002080_prenatal_lethality1.02720504
105MP0005166_decreased_susceptibility_to1.01928182
106MP0008058_abnormal_DNA_repair1.00350729
107MP0000313_abnormal_cell_death0.99899868
108MP0000350_abnormal_cell_proliferation0.99295822
109MP0008877_abnormal_DNA_methylation0.98432849
110MP0001502_abnormal_circadian_rhythm0.96866601
111MP0004233_abnormal_muscle_weight0.96238230
112MP0002398_abnormal_bone_marrow0.95708918
113MP0003787_abnormal_imprinting0.94714113
114MP0003091_abnormal_cell_migration0.93960559
115MP0002970_abnormal_white_adipose0.93768654
116MP0001958_emphysema0.93722842
117MP0008874_decreased_physiological_sensi0.93034416
118MP0003119_abnormal_digestive_system0.92923868
119MP0001666_abnormal_nutrient_absorption0.91533219
120MP0001697_abnormal_embryo_size0.91055573
121MP0001849_ear_inflammation0.88782391
122MP0005448_abnormal_energy_balance0.88597340
123MP0004381_abnormal_hair_follicle0.88259175
124MP0005384_cellular_phenotype0.87849035
125MP0003953_abnormal_hormone_level0.87659090
126MP0000703_abnormal_thymus_morphology0.86625913
127MP0004197_abnormal_fetal_growth/weight/0.84994330
128MP0003279_aneurysm0.84819520
129MP0002166_altered_tumor_susceptibility0.83797028
130MP0000598_abnormal_liver_morphology0.82952992
131MP0002722_abnormal_immune_system0.81974181
132MP0004811_abnormal_neuron_physiology0.81498705
133MP0001853_heart_inflammation0.80935925
134MP0003795_abnormal_bone_structure0.80589605
135MP0002933_joint_inflammation0.80278854
136MP0005621_abnormal_cell_physiology0.78705399
137MP0002086_abnormal_extraembryonic_tissu0.78505607
138MP0002019_abnormal_tumor_incidence0.77990989
139MP0003045_fibrosis0.77409553
140MP0001986_abnormal_taste_sensitivity0.76500058
141MP0003436_decreased_susceptibility_to0.76483744
142MP0000920_abnormal_myelination0.76451318
143MP0005646_abnormal_pituitary_gland0.76256409
144MP0005551_abnormal_eye_electrophysiolog0.75887079
145MP0002084_abnormal_developmental_patter0.75654902
146MP0009763_increased_sensitivity_to0.75220975
147MP0005310_abnormal_salivary_gland0.74813995
148MP0003448_altered_tumor_morphology0.72995625
149MP0000343_altered_response_to0.72569004
150MP0003566_abnormal_cell_adhesion0.70921771
151MP0002429_abnormal_blood_cell0.70413801
152MP0000689_abnormal_spleen_morphology0.70386846
153MP0008770_decreased_survivor_rate0.69916926
154MP0005187_abnormal_penis_morphology0.69834118
155MP0010368_abnormal_lymphatic_system0.69519321
156MP0009703_decreased_birth_body0.68698197
157MP0010386_abnormal_urinary_bladder0.68390186
158MP0003879_abnormal_hair_cell0.68197004
159MP0004130_abnormal_muscle_cell0.68126336
160MP0000685_abnormal_immune_system0.67854132
161MP0002009_preneoplasia0.67337635
162MP0003984_embryonic_growth_retardation0.66806425
163MP0001915_intracranial_hemorrhage0.66380765
164MP0003635_abnormal_synaptic_transmissio0.65589493
165MP0000249_abnormal_blood_vessel0.63904087
166MP0009765_abnormal_xenobiotic_induced0.62979447
167MP0001663_abnormal_digestive_system0.62740439
168MP0008438_abnormal_cutaneous_collagen0.52967734

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.47754607
2Recurrent abscess formation (HP:0002722)4.89913708
3Myositis (HP:0100614)4.87203958
4Recurrent bacterial skin infections (HP:0005406)4.68254076
5Abnormality of macrophages (HP:0004311)4.60272587
6Orchitis (HP:0100796)4.33617550
7Elevated erythrocyte sedimentation rate (HP:0003565)4.11143018
8Spontaneous hematomas (HP:0007420)4.09613398
9Recurrent gram-negative bacterial infections (HP:0005420)4.02237382
10Optic neuritis (HP:0100653)3.86700366
11Retrobulbar optic neuritis (HP:0100654)3.86700366
12Hyperacusis (HP:0010780)3.84586186
13Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.73013165
14Insomnia (HP:0100785)3.68439174
15Hypoglycemic seizures (HP:0002173)3.58194090
16Gastrointestinal infarctions (HP:0005244)3.52124892
17Obstructive lung disease (HP:0006536)3.50302768
18Chronic obstructive pulmonary disease (HP:0006510)3.50302768
19Stomatitis (HP:0010280)3.46959535
20Hyperinsulinemic hypoglycemia (HP:0000825)3.33434042
21Recurrent fungal infections (HP:0002841)3.29714377
22Peritonitis (HP:0002586)3.28797262
23Abnormality of the heme biosynthetic pathway (HP:0010472)3.25143789
24Abnormality of endocrine pancreas physiology (HP:0012093)3.22605715
25Abnormality of the pancreatic islet cells (HP:0006476)3.22605715
26Meningitis (HP:0001287)3.20695034
27Cellulitis (HP:0100658)3.20389967
28Mediastinal lymphadenopathy (HP:0100721)3.19825947
29Thrombocytosis (HP:0001894)3.15659030
30Increased IgE level (HP:0003212)3.10457451
31Recurrent skin infections (HP:0001581)3.10072991
32Gingival bleeding (HP:0000225)2.99402337
33Amyloidosis (HP:0011034)2.94962339
34Episodic fever (HP:0001954)2.92963642
35Symptomatic seizures (HP:0011145)2.92827510
36Urticaria (HP:0001025)2.89628009
37Hypoglycemic coma (HP:0001325)2.88660839
38Hand muscle atrophy (HP:0009130)2.86557879
39Visual hallucinations (HP:0002367)2.84337147
40Gingivitis (HP:0000230)2.84085741
41Late onset (HP:0003584)2.83702621
42Elfin facies (HP:0004428)2.76225085
43Papilledema (HP:0001085)2.75593250
44Hypercortisolism (HP:0001578)2.70047700
45Congenital stationary night blindness (HP:0007642)2.69884824
46Encephalitis (HP:0002383)2.69819560
47Chronic mucocutaneous candidiasis (HP:0002728)2.67990474
48Recurrent cutaneous fungal infections (HP:0011370)2.67990474
49Enlarged penis (HP:0000040)2.66361627
50Arterial thrombosis (HP:0004420)2.61972817
51Keratoconjunctivitis sicca (HP:0001097)2.60825742
52Chest pain (HP:0100749)2.60746975
53Vasculitis (HP:0002633)2.59981272
54Pulmonary embolism (HP:0002204)2.59671764
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.58043483
56Urinary glycosaminoglycan excretion (HP:0003541)2.57704958
57Mucopolysacchariduria (HP:0008155)2.57704958
58Reticulocytosis (HP:0001923)2.57234499
59Macroorchidism (HP:0000053)2.53866849
60Purpura (HP:0000979)2.52566170
61Aplastic anemia (HP:0001915)2.49302042
62Pancreatic islet-cell hyperplasia (HP:0004510)2.48216674
63Hemoptysis (HP:0002105)2.47944478
64Gastrointestinal inflammation (HP:0004386)2.46922401
65Bowel diverticulosis (HP:0005222)2.41399591
66Anorexia (HP:0002039)2.40976651
67Abnormal platelet volume (HP:0011876)2.39243479
68Inflammation of the large intestine (HP:0002037)2.38452704
69Broad palm (HP:0001169)2.36664585
70Upper limb amyotrophy (HP:0009129)2.35679895
71Distal upper limb amyotrophy (HP:0007149)2.35679895
72Granulocytopenia (HP:0001913)2.34276244
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33961340
74Abnormality of polysaccharide metabolism (HP:0011012)2.33961340
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33961340
76Renal duplication (HP:0000075)2.29351805
77Abnormality of the peritoneum (HP:0002585)2.27905450
78Increased cerebral lipofuscin (HP:0011813)2.26674637
79Keratoconjunctivitis (HP:0001096)2.25644226
80Slow saccadic eye movements (HP:0000514)2.22764329
81Depression (HP:0000716)2.22330253
82Acute lymphatic leukemia (HP:0006721)2.21645052
83Polygenic inheritance (HP:0010982)2.21104737
84Growth hormone excess (HP:0000845)2.20778678
85Abnormal delayed hypersensitivity skin test (HP:0002963)2.20388066
86Loss of speech (HP:0002371)2.20021688
87Abnormality of the lower motor neuron (HP:0002366)2.19784789
88Abnormality of calcium-phosphate metabolism (HP:0100530)2.18827142
89Panhypogammaglobulinemia (HP:0003139)2.18583612
90Renovascular hypertension (HP:0100817)2.18579627
91Leukocytosis (HP:0001974)2.16779005
92Impaired smooth pursuit (HP:0007772)2.16636259
93Impaired platelet aggregation (HP:0003540)2.15938898
94Abnormal platelet function (HP:0011869)2.15938898
95Severe short stature (HP:0003510)2.15798533
96Ketoacidosis (HP:0001993)2.14997762
97Hypochromic anemia (HP:0001931)2.14493142
98Increased neuronal autofluorescent lipopigment (HP:0002074)2.14486265
99Supranuclear gaze palsy (HP:0000605)2.12898518
100Generalized hyperpigmentation (HP:0007440)2.12555992
101Prolonged bleeding time (HP:0003010)2.12466877
102Petechiae (HP:0000967)2.12191014
103Prominent metopic ridge (HP:0005487)2.11533170
104Colitis (HP:0002583)2.11150739
105Recurrent viral infections (HP:0004429)2.09472158
106Pustule (HP:0200039)2.09131379
107Obstructive sleep apnea (HP:0002870)2.08403003
108Pulmonary infiltrates (HP:0002113)2.08375776
109Hypergammaglobulinemia (HP:0010702)2.08242086
110Ependymoma (HP:0002888)2.08136025
111Spinal canal stenosis (HP:0003416)2.08059773
112Dysostosis multiplex (HP:0000943)2.07651640
113Hypochromic microcytic anemia (HP:0004840)2.06160034
114Long toe (HP:0010511)2.05549258
115Pointed chin (HP:0000307)2.04689926
116Poikilocytosis (HP:0004447)2.04191606
117Abnormality of the intrinsic pathway (HP:0010989)2.02419348
118Syringomyelia (HP:0003396)2.01419878
119Spinal cord lesions (HP:0100561)2.01419878
120Severe visual impairment (HP:0001141)2.00327774
121Osteomyelitis (HP:0002754)1.99732523
122Sepsis (HP:0100806)1.98908347
123Menorrhagia (HP:0000132)1.97413376
124Resting tremor (HP:0002322)1.97044523
125Amaurosis fugax (HP:0100576)1.96642713
126Increased nuchal translucency (HP:0010880)1.95411591
127Cerebral aneurysm (HP:0004944)1.94983992
128Thin bony cortex (HP:0002753)1.94828239
129Hepatosplenomegaly (HP:0001433)1.94606863
130Broad face (HP:0000283)1.94236085
131Neoplasm of the heart (HP:0100544)1.93908665
13211 pairs of ribs (HP:0000878)1.92802811
133Myocardial infarction (HP:0001658)1.90904401
134Epistaxis (HP:0000421)1.90839532
135Large for gestational age (HP:0001520)1.90075520
136Insulin resistance (HP:0000855)1.89635688
137Increased serum ferritin (HP:0003281)1.88683864
138Fatigue (HP:0012378)1.88175291
139EEG with generalized epileptiform discharges (HP:0011198)1.86456798
140Glomerulopathy (HP:0100820)1.86434885
141Microcytic anemia (HP:0001935)1.86225273
142Retinal atrophy (HP:0001105)1.85741073
143Agitation (HP:0000713)1.85677425
144Cutaneous melanoma (HP:0012056)1.82490822
145Truncal obesity (HP:0001956)1.82164901
146Dilatation of the ascending aorta (HP:0005111)1.81445863
147Cholecystitis (HP:0001082)1.81035151
148Abnormal gallbladder physiology (HP:0012438)1.81035151
149Acne (HP:0001061)1.80853699
150Disproportionate tall stature (HP:0001519)1.80103633
151Abnormality of ocular smooth pursuit (HP:0000617)1.79606895
152Cheilitis (HP:0100825)1.79541409
153Abnormality of the endocardium (HP:0004306)1.78998249
154Testicular neoplasm (HP:0010788)1.78869341
155Neuronal loss in central nervous system (HP:0002529)1.78857433
156Ragged-red muscle fibers (HP:0003200)1.78708630
157Bruising susceptibility (HP:0000978)1.78197666
158Slender long bone (HP:0003100)1.77188668
159Epileptiform EEG discharges (HP:0011182)1.76013691
160Ankyloglossia (HP:0010296)1.75289543
161Hypertriglyceridemia (HP:0002155)1.75229118
162Increased IgM level (HP:0003496)1.75205491
163Poikiloderma (HP:0001029)1.75171391
164Abnormal number of erythroid precursors (HP:0012131)1.74333318
165Metaphyseal cupping (HP:0003021)1.74196462
166Hemorrhage of the eye (HP:0011885)1.73666758
167Acanthocytosis (HP:0001927)1.72384836
168Abnormality of reticulocytes (HP:0004312)1.71954825
169Acute hepatic failure (HP:0006554)1.71807559
170Abnormality of the anterior horn cell (HP:0006802)1.71084224
171Degeneration of anterior horn cells (HP:0002398)1.71084224
172Thrombophlebitis (HP:0004418)1.70935274
173Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70064122
174Abnormality of T cell physiology (HP:0011840)1.69582639
175Viral hepatitis (HP:0006562)1.69301562
176Abnormality of glycolipid metabolism (HP:0010969)1.69167101
177Abnormality of glycosphingolipid metabolism (HP:0004343)1.69167101
178Cervical subluxation (HP:0003308)1.67290237
179Limb hypertonia (HP:0002509)1.66860755
180Hypsarrhythmia (HP:0002521)1.66610414
181Central scotoma (HP:0000603)1.65993553
182Overriding aorta (HP:0002623)1.65660810
183Abnormal rod and cone electroretinograms (HP:0008323)1.65542320
184Abnormality of the metopic suture (HP:0005556)1.64646378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.85795779
2PASK3.79776059
3PKN23.75765075
4TRIB33.37306001
5EEF2K3.36782419
6ERN13.18069188
7SCYL23.05066843
8PRPF4B2.99166888
9FLT32.90389119
10IRAK42.79583153
11TAOK32.45623106
12MAP3K32.21424335
13BLK2.18047180
14TYK22.15086274
15PRKD32.05719401
16MAP3K102.01816216
17EPHB12.00841298
18RIPK11.91527189
19INSRR1.83766549
20HIPK21.80520368
21CSK1.76738263
22NEK11.72490314
23CDC71.68324780
24CAMKK11.64585235
25CAMKK21.57853720
26BRSK21.56923267
27PTK61.56895965
28MAP3K131.56828271
29FGR1.49632809
30TGFBR11.45691674
31BTK1.44089123
32HCK1.42549733
33SMG11.42123937
34DAPK11.41541525
35BRSK11.39105449
36MARK21.34323114
37IRAK21.32418984
38ALK1.30875896
39TSSK61.27649336
40CDK121.26701809
41MAP4K11.24879652
42TNK21.20129011
43ZAP701.19422614
44MAP2K31.19204514
45TAOK11.18755214
46JAK31.17594830
47CDK81.16567342
48SIK31.14129308
49MAP3K141.09874489
50RPS6KB21.08463407
51NEK21.07041271
52MAP3K11.06941302
53TBK11.05682784
54DAPK21.04085240
55PDPK11.03615401
56FES1.03212058
57PAK41.03114071
58ATR1.02092907
59PDK10.97491503
60SIK10.96752469
61JAK10.96497010
62NTRK30.91561328
63RPS6KA20.91461544
64MARK30.90300326
65PDGFRA0.89798726
66IRAK30.89111968
67PTK20.88034315
68BCKDK0.87746050
69LYN0.87504818
70RPS6KA40.86926672
71MAP3K70.85704210
72MTOR0.85097695
73CSF1R0.83841479
74RET0.83382195
75ICK0.81584550
76IKBKE0.81140095
77LCK0.80850400
78MAPK120.79861379
79TESK20.78404803
80SGK30.76068237
81IRAK10.75485719
82MAP3K110.75441964
83YES10.75364043
84MAP3K20.74857422
85JAK20.74669854
86CDK70.74626685
87BMX0.73591880
88KIT0.72339315
89EPHA30.71875579
90CAMK1D0.70655996
91PRKCH0.69600714
92STK100.68599920
93MAPK70.68577900
94CDK190.67803311
95PRKD20.67581863
96CDC42BPA0.67576450
97DYRK30.66437383
98LRRK20.66275220
99KSR20.66077511
100STK380.65849073
101ITK0.64434899
102UHMK10.63792597
103BRD40.63369098
104MINK10.63213157
105ARAF0.62192409
106RPS6KB10.61735810
107FYN0.61671143
108MAP3K80.61182572
109MAP3K60.61158697
110RAF10.61030074
111STK110.60704915
112SYK0.59241699
113BMPR20.58343050
114CDK40.58244310
115MAPK110.57742118
116FGFR30.56608413
117NTRK10.56295300
118PAK20.55972779
119TXK0.55853905
120TTN0.55169191
121EIF2AK10.53084885
122MAP2K40.52774961
123MAP2K60.51672121
124DYRK1B0.51352384
125CCNB10.51042320
126MOS0.49983737
127CHEK10.49699744
128PTK2B0.48883914
129MATK0.48278343
130SGK4940.48065940
131SGK2230.48065940
132CDK20.47645383
133RPS6KC10.46638600
134RPS6KL10.46638600
135TAOK20.46486179
136GRK60.45620040
137PAK60.45342633
138SIK20.44194507
139SGK20.44091477
140TEC0.43648059
141RPS6KA60.43434459
142KSR10.43094592
143CAMK1G0.42080542
144MAPK150.41934989
145WEE10.41455580
146PRKDC0.41149305
147MAPK140.40861141
148MAP2K20.40287402
149PRKG20.34916728
150CAMK10.34879843
151ATM0.34110664
152MAPKAPK30.32968788
153AKT10.31009065
154FGFR40.30392922
155MAPK10.30017764
156CAMK40.29952365
157RPS6KA10.27883252

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.87864851
2Osteoclast differentiation_Homo sapiens_hsa043802.68964886
3DNA replication_Homo sapiens_hsa030302.65536606
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.57009005
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45121880
6Leishmaniasis_Homo sapiens_hsa051402.41137322
7N-Glycan biosynthesis_Homo sapiens_hsa005102.29040074
8Insulin secretion_Homo sapiens_hsa049112.28129293
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.21426503
10B cell receptor signaling pathway_Homo sapiens_hsa046622.16136395
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.14089513
12One carbon pool by folate_Homo sapiens_hsa006702.11005396
13Staphylococcus aureus infection_Homo sapiens_hsa051501.87809370
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86541889
15Protein export_Homo sapiens_hsa030601.86255796
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79840562
17Tuberculosis_Homo sapiens_hsa051521.79406961
18Synaptic vesicle cycle_Homo sapiens_hsa047211.77202533
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.76431352
20Galactose metabolism_Homo sapiens_hsa000521.75835760
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.74697256
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69358326
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68569857
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66809173
25Type II diabetes mellitus_Homo sapiens_hsa049301.65545742
26Selenocompound metabolism_Homo sapiens_hsa004501.64723954
27Mismatch repair_Homo sapiens_hsa034301.61159724
28Biosynthesis of amino acids_Homo sapiens_hsa012301.59028878
29Type I diabetes mellitus_Homo sapiens_hsa049401.55847335
30Chemokine signaling pathway_Homo sapiens_hsa040621.51034137
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.43766750
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42337161
33Malaria_Homo sapiens_hsa051441.40770146
34T cell receptor signaling pathway_Homo sapiens_hsa046601.30787731
35GABAergic synapse_Homo sapiens_hsa047271.30005602
36VEGF signaling pathway_Homo sapiens_hsa043701.29804264
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28944215
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28921648
39Base excision repair_Homo sapiens_hsa034101.28328321
40Phagosome_Homo sapiens_hsa041451.25914124
41Toxoplasmosis_Homo sapiens_hsa051451.25249140
42Pancreatic cancer_Homo sapiens_hsa052121.22870783
43Measles_Homo sapiens_hsa051621.21538945
44RNA transport_Homo sapiens_hsa030131.19360018
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19356703
46Influenza A_Homo sapiens_hsa051641.15438684
47Fructose and mannose metabolism_Homo sapiens_hsa000511.15082303
48Lysine degradation_Homo sapiens_hsa003101.14147279
49TNF signaling pathway_Homo sapiens_hsa046681.13838251
50mTOR signaling pathway_Homo sapiens_hsa041501.13245373
51Chronic myeloid leukemia_Homo sapiens_hsa052201.12242784
52Vibrio cholerae infection_Homo sapiens_hsa051101.11834661
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.10698409
54Glucagon signaling pathway_Homo sapiens_hsa049221.09974390
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.09245263
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.09053305
57Spliceosome_Homo sapiens_hsa030401.08996650
58GnRH signaling pathway_Homo sapiens_hsa049121.08846069
59Pentose phosphate pathway_Homo sapiens_hsa000301.08758964
60NF-kappa B signaling pathway_Homo sapiens_hsa040641.08735604
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07560883
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07268341
63Graft-versus-host disease_Homo sapiens_hsa053321.04242194
64Renal cell carcinoma_Homo sapiens_hsa052111.03328426
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03169812
66Notch signaling pathway_Homo sapiens_hsa043301.02805923
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02743292
68Primary immunodeficiency_Homo sapiens_hsa053401.02621189
69Hematopoietic cell lineage_Homo sapiens_hsa046401.01388171
70Cocaine addiction_Homo sapiens_hsa050301.01258040
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99594870
72Endocytosis_Homo sapiens_hsa041440.99200633
73Circadian entrainment_Homo sapiens_hsa047130.98156315
74Pertussis_Homo sapiens_hsa051330.97697804
75Allograft rejection_Homo sapiens_hsa053300.97675184
76Cell cycle_Homo sapiens_hsa041100.97668279
77Pancreatic secretion_Homo sapiens_hsa049720.97457537
78Endometrial cancer_Homo sapiens_hsa052130.97107551
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.96927654
80Non-small cell lung cancer_Homo sapiens_hsa052230.96751119
81Insulin resistance_Homo sapiens_hsa049310.94812369
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.94299059
83Salmonella infection_Homo sapiens_hsa051320.93684744
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.93207139
85Herpes simplex infection_Homo sapiens_hsa051680.93094089
86Shigellosis_Homo sapiens_hsa051310.92937282
87African trypanosomiasis_Homo sapiens_hsa051430.91640652
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91573054
89Choline metabolism in cancer_Homo sapiens_hsa052310.91114445
90Thyroid cancer_Homo sapiens_hsa052160.88987131
91Circadian rhythm_Homo sapiens_hsa047100.87571902
92Inositol phosphate metabolism_Homo sapiens_hsa005620.87026455
93mRNA surveillance pathway_Homo sapiens_hsa030150.86884927
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86559246
95Hepatitis C_Homo sapiens_hsa051600.86101044
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85832345
97Autoimmune thyroid disease_Homo sapiens_hsa053200.85307681
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84551780
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84506596
100Amoebiasis_Homo sapiens_hsa051460.83623829
101ErbB signaling pathway_Homo sapiens_hsa040120.83534445
102Apoptosis_Homo sapiens_hsa042100.83503656
103Morphine addiction_Homo sapiens_hsa050320.83384390
104Bladder cancer_Homo sapiens_hsa052190.83063525
105ABC transporters_Homo sapiens_hsa020100.82692749
106Legionellosis_Homo sapiens_hsa051340.82076722
107Lysosome_Homo sapiens_hsa041420.82050037
108Acute myeloid leukemia_Homo sapiens_hsa052210.81804183
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80042482
110Thyroid hormone synthesis_Homo sapiens_hsa049180.80023277
111Viral myocarditis_Homo sapiens_hsa054160.79777876
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77270576
113Prolactin signaling pathway_Homo sapiens_hsa049170.75748833
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.73049621
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73049038
116Nucleotide excision repair_Homo sapiens_hsa034200.72880449
117Dopaminergic synapse_Homo sapiens_hsa047280.72280968
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71768699
119Carbon metabolism_Homo sapiens_hsa012000.70883585
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70757829
121Cholinergic synapse_Homo sapiens_hsa047250.70234937
122Insulin signaling pathway_Homo sapiens_hsa049100.69462396
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69365023
124Estrogen signaling pathway_Homo sapiens_hsa049150.68411796
125Glioma_Homo sapiens_hsa052140.66138243
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.66127561
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65487147
128MAPK signaling pathway_Homo sapiens_hsa040100.65309828
129Long-term potentiation_Homo sapiens_hsa047200.65196880
130Rap1 signaling pathway_Homo sapiens_hsa040150.64807133
131Colorectal cancer_Homo sapiens_hsa052100.64510604
132FoxO signaling pathway_Homo sapiens_hsa040680.64353822
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64286037
134Amphetamine addiction_Homo sapiens_hsa050310.63717411
135Platelet activation_Homo sapiens_hsa046110.62932577
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62327818
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58796114
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58087258
139RNA degradation_Homo sapiens_hsa030180.57861248
140Non-homologous end-joining_Homo sapiens_hsa034500.57069935
141HIF-1 signaling pathway_Homo sapiens_hsa040660.56040643
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.54678524
143Folate biosynthesis_Homo sapiens_hsa007900.54424791
144Pyrimidine metabolism_Homo sapiens_hsa002400.53561411
145Antigen processing and presentation_Homo sapiens_hsa046120.53459257
146Nicotine addiction_Homo sapiens_hsa050330.53311648
147Prion diseases_Homo sapiens_hsa050200.53079747
148Regulation of autophagy_Homo sapiens_hsa041400.52270363
149Alcoholism_Homo sapiens_hsa050340.51725698
150Gap junction_Homo sapiens_hsa045400.51473353
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.50070941
152Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49954174
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47979297
154Viral carcinogenesis_Homo sapiens_hsa052030.47554325
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44904119
156Other glycan degradation_Homo sapiens_hsa005110.44752141
157Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44524971
158AMPK signaling pathway_Homo sapiens_hsa041520.43538470
159Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40602739
160Adipocytokine signaling pathway_Homo sapiens_hsa049200.40428760
161HTLV-I infection_Homo sapiens_hsa051660.38508820
162Bile secretion_Homo sapiens_hsa049760.38387193
163Hepatitis B_Homo sapiens_hsa051610.38118274
164Starch and sucrose metabolism_Homo sapiens_hsa005000.38089333

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