AMPD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AMP deaminase gene family. The encoded protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. This gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact6.50695172
2modulation by symbiont of host immune response (GO:0052553)6.50695172
3positive regulation by symbiont of host defense response (GO:0052509)6.50695172
4modulation by symbiont of host defense response (GO:0052031)6.50695172
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.50695172
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.50695172
7macrophage activation involved in immune response (GO:0002281)5.07709521
8regulation of vitamin D biosynthetic process (GO:0060556)4.79808653
9response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.61115866
10response to host immune response (GO:0052572)4.61115866
11regulation of interferon-beta biosynthetic process (GO:0045357)4.47435635
12response to host (GO:0075136)4.39959026
13response to host defenses (GO:0052200)4.39959026
14response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.39959026
15response to peptidoglycan (GO:0032494)4.37482986
16positive regulation of cellular amide metabolic process (GO:0034250)4.03267311
17detection of molecule of bacterial origin (GO:0032490)3.99118137
18NIK/NF-kappaB signaling (GO:0038061)3.98047459
19regulation of T-helper 1 cell differentiation (GO:0045625)3.94492278
20microglial cell activation (GO:0001774)3.90002106
21regulation of podosome assembly (GO:0071801)3.76485560
22regulation of vitamin metabolic process (GO:0030656)3.72959420
23regulation of cytokine secretion involved in immune response (GO:0002739)3.72658183
24neutrophil activation involved in immune response (GO:0002283)3.68558775
25positive regulation of chemokine biosynthetic process (GO:0045080)3.67470784
26positive regulation of interferon-alpha production (GO:0032727)3.53321765
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.46950009
28regulation of chronic inflammatory response (GO:0002676)3.46869998
29negative regulation of cytokine production involved in immune response (GO:0002719)3.46148142
30response to protozoan (GO:0001562)3.42043700
31cellular response to type I interferon (GO:0071357)3.40908502
32type I interferon signaling pathway (GO:0060337)3.40908502
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.40103595
34negative regulation of cell killing (GO:0031342)3.40103595
35negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.39120891
36response to type I interferon (GO:0034340)3.38394555
37macrophage activation (GO:0042116)3.36701099
38regulation of interferon-alpha production (GO:0032647)3.35636501
39defense response to protozoan (GO:0042832)3.32518111
40response to muramyl dipeptide (GO:0032495)3.31977133
41I-kappaB phosphorylation (GO:0007252)3.31503316
42lipopolysaccharide-mediated signaling pathway (GO:0031663)3.28774428
43myeloid dendritic cell differentiation (GO:0043011)3.27784913
44positive regulation of gamma-delta T cell activation (GO:0046645)3.16420054
45monocyte chemotaxis (GO:0002548)3.15745739
46positive regulation of p38MAPK cascade (GO:1900745)3.14430998
47positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.07700890
48positive regulation of heat generation (GO:0031652)3.05764890
49regulation of T-helper 2 cell differentiation (GO:0045628)3.05457175
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.05208898
51cellular response to thyroid hormone stimulus (GO:0097067)3.04705930
52negative regulation of nitric oxide biosynthetic process (GO:0045019)3.02916777
53positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.02646402
54glycosphingolipid catabolic process (GO:0046479)3.01295034
55positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.00653406
56cellular response to lipopolysaccharide (GO:0071222)2.98503758
57leukocyte migration involved in inflammatory response (GO:0002523)2.95876920
58positive regulation of type 2 immune response (GO:0002830)2.95849978
59regulation of interleukin-8 biosynthetic process (GO:0045414)2.95768579
60regulation of interleukin-12 production (GO:0032655)2.95126282
61cellular response to molecule of bacterial origin (GO:0071219)2.92690323
62myeloid dendritic cell activation (GO:0001773)2.91819567
63regulation of gamma-delta T cell activation (GO:0046643)2.91099341
64oligosaccharide catabolic process (GO:0009313)2.90946671
65regulation of fever generation (GO:0031620)2.89490347
66detection of biotic stimulus (GO:0009595)2.88734416
67myeloid cell activation involved in immune response (GO:0002275)2.87581678
68regulation of heat generation (GO:0031650)2.85922510
69negative regulation of lipid storage (GO:0010888)2.85738764
70detection of bacterium (GO:0016045)2.84667706
71positive regulation of interleukin-6 production (GO:0032755)2.84158288
72regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.83656030
73positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.83397617
74regulation of macrophage cytokine production (GO:0010935)2.82748924
75regulation of integrin activation (GO:0033623)2.81802614
76detection of external biotic stimulus (GO:0098581)2.81579763
77branching involved in labyrinthine layer morphogenesis (GO:0060670)2.81424262
78regulation of antigen processing and presentation (GO:0002577)2.79824053
79low-density lipoprotein particle clearance (GO:0034383)2.78821991
80negative regulation of production of molecular mediator of immune response (GO:0002701)2.78718131
81negative regulation of erythrocyte differentiation (GO:0045647)2.78176867
82cell adhesion mediated by integrin (GO:0033627)2.77637997
83immunoglobulin mediated immune response (GO:0016064)2.74763271
84positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.74737095
85regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.73899111
86negative regulation of interleukin-12 production (GO:0032695)2.73745668
87regulation of nitric oxide biosynthetic process (GO:0045428)2.73158323
88modulation of growth of symbiont involved in interaction with host (GO:0044144)2.72984809
89regulation of growth of symbiont in host (GO:0044126)2.72984809
90negative regulation of growth of symbiont in host (GO:0044130)2.72984809
91negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.72984809
92negative regulation of myeloid cell apoptotic process (GO:0033033)2.72878266
93positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.72667204
94respiratory burst (GO:0045730)2.72594456
95hydrogen peroxide biosynthetic process (GO:0050665)2.72305400
96regulation of interleukin-6 production (GO:0032675)2.70576438
97apoptotic cell clearance (GO:0043277)2.70334355
98regulation of type 2 immune response (GO:0002828)2.69996310
99plasma membrane repair (GO:0001778)2.69862332
100leukocyte aggregation (GO:0070486)2.69594717
101cellular response to interferon-gamma (GO:0071346)2.68648230
102positive regulation of interferon-beta production (GO:0032728)2.68485994
103positive regulation of acute inflammatory response (GO:0002675)2.67108232
104glycolipid catabolic process (GO:0019377)2.67038120
105positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66822298
106regulation of NF-kappaB import into nucleus (GO:0042345)2.66525511
107regulation of membrane protein ectodomain proteolysis (GO:0051043)2.62272763
108regulation of dendritic cell antigen processing and presentation (GO:0002604)2.61734275
109antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60653781
110regulation of interleukin-12 biosynthetic process (GO:0045075)2.58273612
111regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.58024313
112positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.57907749
113regulation of chemokine biosynthetic process (GO:0045073)2.56772274
114positive regulation of toll-like receptor signaling pathway (GO:0034123)2.56745536
115germinal center formation (GO:0002467)2.56402828
116pinocytosis (GO:0006907)2.55994087
117superoxide anion generation (GO:0042554)2.51431508
118cellular extravasation (GO:0045123)2.50632799
119regulation of cholesterol storage (GO:0010885)2.49793642
120regulation of B cell receptor signaling pathway (GO:0050855)2.49509277
121modulation by symbiont of host cellular process (GO:0044068)2.48856415
122regulation of p38MAPK cascade (GO:1900744)2.48826511
123positive regulation of macrophage cytokine production (GO:0060907)2.48075341
124regulation of mononuclear cell migration (GO:0071675)2.48012965
125detection of other organism (GO:0098543)2.46391063
126granulocyte activation (GO:0036230)2.45866344
127positive regulation of chemokine production (GO:0032722)2.44154327
128neutrophil mediated immunity (GO:0002446)2.42575912
129regulation of mast cell degranulation (GO:0043304)2.41389618
130positive regulation of antigen processing and presentation (GO:0002579)2.39996634
131macroautophagy (GO:0016236)2.38487896
132neutrophil activation (GO:0042119)2.36764640
133negative regulation of complement activation (GO:0045916)2.34301167
134regulation of mast cell activation involved in immune response (GO:0033006)2.34224394
135T-helper 1 type immune response (GO:0042088)2.32574099
136positive regulation of mast cell activation involved in immune response (GO:0033008)2.32379746
137positive regulation of mast cell degranulation (GO:0043306)2.32379746
138leukocyte cell-cell adhesion (GO:0007159)2.32275920
139modification by symbiont of host morphology or physiology (GO:0044003)2.31940854
140cellular response to zinc ion (GO:0071294)2.30884830
141regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.27303852
142neutrophil chemotaxis (GO:0030593)2.25801657
143negative regulation of mast cell activation (GO:0033004)2.25533577
144positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.24999613
145positive regulation of mast cell activation (GO:0033005)2.23320778
146regulation of mast cell activation (GO:0033003)2.23046156
147reactive oxygen species biosynthetic process (GO:1903409)2.23025257
148neutrophil migration (GO:1990266)2.21659805
149natural killer cell mediated immunity (GO:0002228)2.21056912
150natural killer cell mediated cytotoxicity (GO:0042267)2.21056912
151positive regulation of NF-kappaB import into nucleus (GO:0042346)2.20707363
152interferon-gamma-mediated signaling pathway (GO:0060333)2.20604759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.34416668
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.63412212
3* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.36140002
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.22800185
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.15796429
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15163721
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.04472669
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02803465
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86446443
10* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.56775481
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48394664
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44008902
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36991862
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36398918
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.33609963
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.27719303
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20624443
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04992414
19* SPI1_23127762_ChIP-Seq_K562_Human2.02722624
20SCL_19346495_ChIP-Seq_HPC-7_Human2.01539164
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98950133
22* GATA2_21666600_ChIP-Seq_HMVEC_Human1.91781782
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86663741
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85489214
25VDR_24787735_ChIP-Seq_THP-1_Human1.82417952
26SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.75525445
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.72341299
28GATA1_19941827_ChIP-Seq_MEL_Mouse1.71235353
29* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69717501
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68858089
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64603743
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64210830
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60356689
34NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.58808450
35* MYB_26560356_Chip-Seq_TH2_Human1.57588122
36RUNX_20019798_ChIP-Seq_JUKART_Human1.54688487
37GATA1_22025678_ChIP-Seq_K562_Human1.54611932
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52128906
39* GATA1_19941826_ChIP-Seq_K562_Human1.49754361
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49474128
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.49400418
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.48781671
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46681228
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44126439
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41965597
46* GATA2_19941826_ChIP-Seq_K562_Human1.40674523
47CJUN_26792858_Chip-Seq_BT549_Human1.38382397
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.37928630
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36887330
50* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35643078
51* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32905795
52PU_27001747_Chip-Seq_BMDM_Mouse1.31765423
53* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31188524
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30259232
55* FOXO3_23340844_ChIP-Seq_DLD1_Human1.29980233
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29026273
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28287290
58MYC_22102868_ChIP-Seq_BL_Human1.27482716
59VDR_24763502_ChIP-Seq_THP-1_Human1.26602870
60* UTX_26944678_Chip-Seq_JUKART_Human1.24167617
61LXR_22292898_ChIP-Seq_THP-1_Human1.23446986
62* MYB_26560356_Chip-Seq_TH1_Human1.22266279
63* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22014815
64* MAF_26560356_Chip-Seq_TH1_Human1.20969715
65KDM2B_26808549_Chip-Seq_DND41_Human1.19216995
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19012069
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18233704
68* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18180993
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.16745024
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.16745024
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16503629
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15317997
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13076454
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13040350
75* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12764320
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.11445091
77* EP300_21415370_ChIP-Seq_HL-1_Mouse1.11348999
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11200735
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11200735
80TCF7_22412390_ChIP-Seq_EML_Mouse1.10461281
81FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10132898
82TP63_17297297_ChIP-ChIP_HaCaT_Human1.09642567
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.09641219
84* GATA3_27048872_Chip-Seq_THYMUS_Human1.09535087
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09487697
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09303628
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08984752
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08185346
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07684406
90* SPI1_23547873_ChIP-Seq_NB4_Human1.07601786
91* MAF_26560356_Chip-Seq_TH2_Human1.07392741
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07292548
93* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06564965
94FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06197114
95* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05886767
96* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05886767
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05639189
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05585730
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03803835
100CLOCK_20551151_ChIP-Seq_293T_Human1.03574863
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03405563
102* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02400245
103SOX2_20726797_ChIP-Seq_SW620_Human1.01331298
104P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00202321
105AR_21572438_ChIP-Seq_LNCaP_Human0.99286141
106VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98754812
107VDR_21846776_ChIP-Seq_THP-1_Human0.97792752
108RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97487183
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97173485
110* GATA3_26560356_Chip-Seq_TH2_Human0.96809282
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95807513
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95742325
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95705625
114STAT1_20625510_ChIP-Seq_HELA_Human0.95629903
115FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93950026
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93145107
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93065853
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92786906
119TP53_16413492_ChIP-PET_HCT116_Human0.92701768
120KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92591787
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92340312
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92225492
123* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92039347
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91862540
125TFEB_21752829_ChIP-Seq_HELA_Human0.84628126
126KDM2B_26808549_Chip-Seq_K562_Human0.83118935
127BCOR_27268052_Chip-Seq_Bcells_Human0.81629041
128PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79672606
129BCL6_27268052_Chip-Seq_Bcells_Human0.79220847
130GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75779106
131* KDM2B_26808549_Chip-Seq_JURKAT_Human0.74966400
132* NCOR1_26117541_ChIP-Seq_K562_Human0.73719240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis3.00506807
2MP0005058_abnormal_lysosome_morphology2.91606795
3MP0003303_peritoneal_inflammation2.82084358
4MP0003656_abnormal_erythrocyte_physiolo2.56115357
5MP0003172_abnormal_lysosome_physiology2.54773674
6MP0003436_decreased_susceptibility_to2.52060078
7MP0009840_abnormal_foam_cell2.48891313
8MP0001835_abnormal_antigen_presentation2.48143428
9MP0003646_muscle_fatigue2.40240827
10MP0000343_altered_response_to2.37793228
11MP0002419_abnormal_innate_immunity2.31413320
12MP0009278_abnormal_bone_marrow2.27368317
13MP0005451_abnormal_body_composition2.24736946
14MP0000685_abnormal_immune_system2.16105131
15MP0002254_reproductive_system_inflammat2.04594394
16MP0004858_abnormal_nervous_system2.04202619
17MP0003566_abnormal_cell_adhesion2.03999376
18MP0003279_aneurysm2.03767806
19MP0009785_altered_susceptibility_to2.01266528
20MP0003075_altered_response_to1.94965513
21MP0002139_abnormal_hepatobiliary_system1.94508323
22MP0001958_emphysema1.93287277
23MP0001790_abnormal_immune_system1.90924311
24MP0005387_immune_system_phenotype1.90924311
25MP0003300_gastrointestinal_ulcer1.85007945
26MP0000569_abnormal_digit_pigmentation1.82202757
27MP0002837_dystrophic_cardiac_calcinosis1.81480780
28MP0008438_abnormal_cutaneous_collagen1.79310541
29MP0004130_abnormal_muscle_cell1.76333896
30MP0009764_decreased_sensitivity_to1.73057738
31MP0003828_pulmonary_edema1.72194086
32MP0005025_abnormal_response_to1.72174506
33MP0003724_increased_susceptibility_to1.70075634
34MP0008004_abnormal_stomach_pH1.69663711
35MP0005464_abnormal_platelet_physiology1.65339642
36MP0004084_abnormal_cardiac_muscle1.65298057
37MP0001533_abnormal_skeleton_physiology1.64657127
38MP0000604_amyloidosis1.61710252
39MP0003183_abnormal_peptide_metabolism1.59910619
40MP0005000_abnormal_immune_tolerance1.58968419
41MP0004947_skin_inflammation1.57789007
42MP0002452_abnormal_antigen_presenting1.55560576
43MP0000751_myopathy1.54939675
44MP0003705_abnormal_hypodermis_morpholog1.51400678
45MP0002148_abnormal_hypersensitivity_rea1.51197817
46MP0004147_increased_porphyrin_level1.51047651
47MP0002138_abnormal_hepatobiliary_system1.49715814
48MP0005670_abnormal_white_adipose1.46896272
49MP0003091_abnormal_cell_migration1.46745009
50MP0005310_abnormal_salivary_gland1.45650465
51MP0005397_hematopoietic_system_phenotyp1.45392582
52MP0001545_abnormal_hematopoietic_system1.45392582
53MP0004215_abnormal_myocardial_fiber1.43888892
54MP0001853_heart_inflammation1.41612545
55MP0006082_CNS_inflammation1.40972928
56MP0009333_abnormal_splenocyte_physiolog1.37006852
57MP0005164_abnormal_response_to1.36526409
58MP0008775_abnormal_heart_ventricle1.36050963
59MP0006054_spinal_hemorrhage1.35849809
60MP0000750_abnormal_muscle_regeneration1.35600408
61MP0003690_abnormal_glial_cell1.35367788
62MP0000716_abnormal_immune_system1.35053987
63MP0003448_altered_tumor_morphology1.34712230
64MP0005167_abnormal_blood-brain_barrier1.33334787
65MP0000749_muscle_degeneration1.33096890
66MP0002972_abnormal_cardiac_muscle1.29817875
67MP0004185_abnormal_adipocyte_glucose1.29540652
68MP0001800_abnormal_humoral_immune1.27721573
69MP0002405_respiratory_system_inflammati1.24734839
70MP0002723_abnormal_immune_serum1.24708251
71MP0003806_abnormal_nucleotide_metabolis1.23953209
72MP0004036_abnormal_muscle_relaxation1.23337009
73MP0005166_decreased_susceptibility_to1.23085452
74MP0000858_altered_metastatic_potential1.21358269
75MP0002398_abnormal_bone_marrow1.18944871
76MP0000767_abnormal_smooth_muscle1.18839731
77MP0001819_abnormal_immune_cell1.16905199
78MP0005666_abnormal_adipose_tissue1.16776687
79MP0003045_fibrosis1.16329443
80MP0003195_calcinosis1.16204695
81MP0004087_abnormal_muscle_fiber1.15597224
82MP0002998_abnormal_bone_remodeling1.13915740
83MP0002420_abnormal_adaptive_immunity1.13846283
84MP0001845_abnormal_inflammatory_respons1.13593357
85MP0004484_altered_response_of1.12192475
86MP0005023_abnormal_wound_healing1.06814794
87MP0001851_eye_inflammation1.06760918
88MP0010630_abnormal_cardiac_muscle1.06501727
89MP0003763_abnormal_thymus_physiology1.06225312
90MP0000689_abnormal_spleen_morphology1.02863202
91MP0002429_abnormal_blood_cell1.02782764
92MP0001544_abnormal_cardiovascular_syste1.02258479
93MP0005385_cardiovascular_system_phenoty1.02258479
94MP0005671_abnormal_response_to1.01655135
95MP0000733_abnormal_muscle_development0.98138237
96MP0002106_abnormal_muscle_physiology0.97533615
97MP0004883_abnormal_blood_vessel0.96304514
98MP0003191_abnormal_cellular_cholesterol0.96257404
99MP0005165_increased_susceptibility_to0.94922146
100MP0002722_abnormal_immune_system0.94410142
101MP0002332_abnormal_exercise_endurance0.93989600
102MP0009763_increased_sensitivity_to0.92118792
103MP0008469_abnormal_protein_level0.91242461
104MP0005620_abnormal_muscle_contractility0.90764548
105MP0003453_abnormal_keratinocyte_physiol0.90176895
106MP0005174_abnormal_tail_pigmentation0.88457886
107MP0000920_abnormal_myelination0.88154264
108MP0000249_abnormal_blood_vessel0.87332062
109MP0008260_abnormal_autophagy0.86893758
110MP0001542_abnormal_bone_strength0.85619187
111MP0010155_abnormal_intestine_physiology0.85421933
112MP0001663_abnormal_digestive_system0.84405147
113MP0005375_adipose_tissue_phenotype0.83034492
114MP0000759_abnormal_skeletal_muscle0.83006913
115MP0005076_abnormal_cell_differentiation0.82562876
116MP0009765_abnormal_xenobiotic_induced0.82384207
117MP0010307_abnormal_tumor_latency0.81539087
118MP0003329_amyloid_beta_deposits0.81398191
119MP0005390_skeleton_phenotype0.80374266
120MP0004808_abnormal_hematopoietic_stem0.79462919
121MP0002933_joint_inflammation0.79180124
122MP0008874_decreased_physiological_sensi0.78231974
123MP0005330_cardiomyopathy0.74563795
124MP0000465_gastrointestinal_hemorrhage0.73104145
125MP0003795_abnormal_bone_structure0.72023039
126MP0005647_abnormal_sex_gland0.68845233
127MP0001501_abnormal_sleep_pattern0.66006117
128MP0002877_abnormal_melanocyte_morpholog0.60954336
129MP0001873_stomach_inflammation0.58726420
130MP0002277_abnormal_respiratory_mucosa0.55728732
131MP0005535_abnormal_body_temperature0.53695763
132MP0010352_gastrointestinal_tract_polyps0.49401171
133MP0000371_diluted_coat_color0.49374904

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.27437641
2Increased cerebral lipofuscin (HP:0011813)5.05780154
3Eczematoid dermatitis (HP:0000976)4.65141120
4Increased neuronal autofluorescent lipopigment (HP:0002074)4.60125958
5Recurrent bacterial skin infections (HP:0005406)4.32467128
6Abnormality of macrophages (HP:0004311)3.88085458
7Mutism (HP:0002300)3.46348598
8Recurrent gram-negative bacterial infections (HP:0005420)3.42022489
9Asymmetric septal hypertrophy (HP:0001670)3.40949179
10Mediastinal lymphadenopathy (HP:0100721)3.25947836
11Keratoconjunctivitis sicca (HP:0001097)3.20865382
12Tetraparesis (HP:0002273)3.20634555
13Neurofibrillary tangles (HP:0002185)3.13878325
14Orchitis (HP:0100796)3.00065573
15Nuclear cataract (HP:0100018)2.97223432
16Hyporeflexia of lower limbs (HP:0002600)2.95378984
17Facial diplegia (HP:0001349)2.94815660
18Vacuolated lymphocytes (HP:0001922)2.92774654
19Axonal loss (HP:0003447)2.92773772
20Keratoconjunctivitis (HP:0001096)2.92697909
21Gingivitis (HP:0000230)2.92044972
22Abnormality of polysaccharide metabolism (HP:0011012)2.88805713
23Abnormality of glycosaminoglycan metabolism (HP:0004371)2.88805713
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.88805713
25Myositis (HP:0100614)2.85973069
26Stomatitis (HP:0010280)2.84946941
27Autoimmune thrombocytopenia (HP:0001973)2.84053896
28Spondylolisthesis (HP:0003302)2.80754615
29Increased connective tissue (HP:0009025)2.80548562
30Disinhibition (HP:0000734)2.79365262
31Dysostosis multiplex (HP:0000943)2.77335343
32Mucopolysacchariduria (HP:0008155)2.76986031
33Urinary glycosaminoglycan excretion (HP:0003541)2.76986031
34Cerebral aneurysm (HP:0004944)2.74038086
35Systemic lupus erythematosus (HP:0002725)2.73530557
36Glomerulonephritis (HP:0000099)2.71169617
37Distal lower limb amyotrophy (HP:0008944)2.65683523
38Recurrent viral infections (HP:0004429)2.61245320
39Apathy (HP:0000741)2.59761134
40T lymphocytopenia (HP:0005403)2.56575399
41Elevated erythrocyte sedimentation rate (HP:0003565)2.55311633
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.54726299
43Exercise-induced myalgia (HP:0003738)2.53211923
44Diminished motivation (HP:0000745)2.53204572
45Amyloidosis (HP:0011034)2.52672720
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.51889364
47Urticaria (HP:0001025)2.50587636
48Arterial tortuosity (HP:0005116)2.50426272
49Frequent falls (HP:0002359)2.49534406
50Hemoptysis (HP:0002105)2.49462716
51Abnormality of the vasculature of the conjunctiva (HP:0008054)2.48952884
52Optic neuritis (HP:0100653)2.48909943
53Retrobulbar optic neuritis (HP:0100654)2.48909943
54Aortic aneurysm (HP:0004942)2.47291913
55Gangrene (HP:0100758)2.45743911
56Meningitis (HP:0001287)2.45310522
57Lower limb amyotrophy (HP:0007210)2.42862704
58Distal lower limb muscle weakness (HP:0009053)2.42533231
59Increased IgE level (HP:0003212)2.41233931
60Neuronal loss in central nervous system (HP:0002529)2.38937227
61Abnormality of iron homeostasis (HP:0011031)2.38863348
62Absent frontal sinuses (HP:0002688)2.38766074
63Purpura (HP:0000979)2.33276601
64Abnormality of liposaccharide metabolism (HP:0010968)2.33209965
65Abnormality of glycosphingolipid metabolism (HP:0004343)2.33209965
66Abnormality of glycolipid metabolism (HP:0010969)2.33209965
67Abnormality of T cell number (HP:0011839)2.33013156
68Prostate neoplasm (HP:0100787)2.32110253
69Pustule (HP:0200039)2.32008213
70EMG: myopathic abnormalities (HP:0003458)2.32005272
71Loss of speech (HP:0002371)2.31974364
72Polyneuropathy (HP:0001271)2.30050014
73Vertebral compression fractures (HP:0002953)2.29880330
74Increased IgM level (HP:0003496)2.29261497
75Exercise-induced muscle cramps (HP:0003710)2.28017996
76Cerebral inclusion bodies (HP:0100314)2.27844370
77Vascular tortuosity (HP:0004948)2.26861571
78Progressive neurologic deterioration (HP:0002344)2.26691491
79Muscle fiber splitting (HP:0003555)2.25165835
80Osteolytic defects of the phalanges of the hand (HP:0009771)2.23611054
81Osteolytic defects of the hand bones (HP:0009699)2.23611054
82Cellulitis (HP:0100658)2.23317390
83Type 1 muscle fiber predominance (HP:0003803)2.21881043
84Arterial thrombosis (HP:0004420)2.21386797
85Gastrointestinal infarctions (HP:0005244)2.21302412
86Spontaneous hematomas (HP:0007420)2.20731832
87Petechiae (HP:0000967)2.18081977
88Encephalitis (HP:0002383)2.17668441
89Abnormality of the nasal mucosa (HP:0000433)2.16417316
90Inappropriate behavior (HP:0000719)2.15119039
91Recurrent skin infections (HP:0001581)2.14888386
92Thick nail (HP:0001805)2.13683293
93Leukocytosis (HP:0001974)2.13619434
94Hepatosplenomegaly (HP:0001433)2.12422995
95Parakeratosis (HP:0001036)2.11150418
96Osteomyelitis (HP:0002754)2.10727144
97Recurrent fungal infections (HP:0002841)2.09318986
98Hematochezia (HP:0002573)2.08915323
99Metaphyseal irregularity (HP:0003025)2.08734633
100Cervical subluxation (HP:0003308)2.07466451
101Obstructive lung disease (HP:0006536)2.07050549
102Chronic obstructive pulmonary disease (HP:0006510)2.07050549
103Atrial fibrillation (HP:0005110)2.06723871
104Episodic fever (HP:0001954)2.05976170
105Agnosia (HP:0010524)2.05760994
106Muscle fiber inclusion bodies (HP:0100299)2.05387694
107Gastrointestinal stroma tumor (HP:0100723)2.05272319
108Difficulty running (HP:0009046)2.04056671
109Right ventricular cardiomyopathy (HP:0011663)2.03514607
110Autoimmune hemolytic anemia (HP:0001890)2.01695388
111Hypergammaglobulinemia (HP:0010702)2.01235243
112Anorexia (HP:0002039)2.01201340
113Upper motor neuron abnormality (HP:0002127)2.00945565
114Dilatation of the ascending aorta (HP:0005111)1.99587592
115Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.99013636
116Ventricular tachycardia (HP:0004756)1.98393057
117Vertigo (HP:0002321)1.97718703
118Action tremor (HP:0002345)1.96057079
119Aortic dissection (HP:0002647)1.95293935
120Increased serum ferritin (HP:0003281)1.94760240
121Nasal polyposis (HP:0100582)1.94608443
122Abnormality of the left ventricular outflow tract (HP:0011103)1.94174659
123Subaortic stenosis (HP:0001682)1.94174659
124Sudden death (HP:0001699)1.92653473
125Lipoatrophy (HP:0100578)1.92541340
126Pulmonary embolism (HP:0002204)1.91732870
127Abnormality of transition element cation homeostasis (HP:0011030)1.91360534
128Malnutrition (HP:0004395)1.90438226
129Vasculitis (HP:0002633)1.90358091
130Restrictive lung disease (HP:0002091)1.89640200
131Premature rupture of membranes (HP:0001788)1.89300223
132Primary atrial arrhythmia (HP:0001692)1.88883766
133Ulnar deviation of the wrist (HP:0003049)1.88633442
134Radial bowing (HP:0002986)1.88022404
135Personality changes (HP:0000751)1.87542864
136Complement deficiency (HP:0004431)1.87218601
137Recurrent cutaneous fungal infections (HP:0011370)1.86762160
138Chronic mucocutaneous candidiasis (HP:0002728)1.86762160
139Abnormality of the pleura (HP:0002103)1.86443211
140Submucous cleft hard palate (HP:0000176)1.85934383
141Pulmonary artery stenosis (HP:0004415)1.85314392
142Reticulocytosis (HP:0001923)1.85152862
143Pulmonary infiltrates (HP:0002113)1.83419807
144Long toe (HP:0010511)1.82624901
145Basal ganglia calcification (HP:0002135)1.82298811
146Periodontitis (HP:0000704)1.81997468
147Broad metatarsal (HP:0001783)1.81840207
148Interstitial pulmonary disease (HP:0006530)1.80850254
149Abnormality of the calf musculature (HP:0001430)1.79981710
150Gowers sign (HP:0003391)1.78367562
151Easy fatigability (HP:0003388)1.78307316
152Scapular winging (HP:0003691)1.76992007
153Myocardial infarction (HP:0001658)1.76853937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.86057911
2TTN3.26460371
3TAOK22.68657650
4NME22.65711248
5RIPK42.64796152
6ERN12.44555906
7TBK12.42909429
8PRPF4B2.36656519
9DDR22.33640737
10DMPK2.18377955
11MAP3K142.05188747
12LMTK21.99993733
13MAP3K111.94730820
14TYK21.91552326
15JAK31.90203416
16MUSK1.86164141
17RIPK11.85275283
18TGFBR21.83107409
19TRPM71.82380684
20TXK1.81507390
21IKBKE1.79953230
22IRAK31.70288942
23IRAK41.66440517
24MAP3K131.60895994
25KSR21.56912817
26TAOK31.55632101
27CDC42BPA1.54775374
28SGK31.49175488
29JAK11.47544273
30KIT1.46823742
31NEK91.43975880
32CAMK1D1.43506118
33EPHB11.43125063
34PHKG11.42724573
35PHKG21.42724573
36BLK1.41153113
37PIM21.38401565
38FGR1.37271543
39MAP4K11.29769774
40FES1.26951705
41TAOK11.24223038
42STK101.22083777
43MOS1.20774559
44ADRBK21.19363389
45MAP3K61.16968058
46MAP2K31.15973785
47PKN21.14761378
48MAP3K11.12911569
49IKBKB1.11557063
50GRK71.10945847
51BMX1.03948688
52ACVR1B1.02422373
53PTK61.01809674
54IRAK11.00705228
55SGK21.00236092
56IRAK20.98834035
57HCK0.97423468
58PRKCH0.94521496
59BMPR20.93941205
60CAMK1G0.92981559
61NTRK10.92679612
62MARK30.90103008
63LRRK20.89361064
64MAP3K50.89032154
65OBSCN0.87994286
66BTK0.87992542
67PRKAA20.87429923
68CSK0.86360520
69JAK20.82688025
70PDGFRA0.81899983
71MAP3K80.81498117
72MATK0.80958033
73RET0.80786500
74FGFR30.79786637
75MAP2K60.74686198
76ERBB40.73566106
77MAP3K30.72442415
78PDPK10.68145601
79MAP2K10.67329059
80CHUK0.67175745
81MST1R0.66663959
82SYK0.65531119
83TYRO30.64070941
84ZAP700.63784472
85MAPK120.63719130
86DAPK20.63527847
87MAP3K90.63082537
88SIK30.61941635
89MAPKAPK30.59833965
90PIM10.58625936
91PDK10.57778876
92PRKG20.57310093
93CLK10.56831158
94PRKD20.55971936
95RPS6KA40.55792940
96SGK10.53478543
97PIK3CA0.53184675
98TNK20.53061025
99MYLK0.52705814
100CSF1R0.52662562
101MAPK40.52317761
102MAPK70.51192748
103EGFR0.50941121
104RPS6KC10.50318627
105RPS6KL10.50318627
106ICK0.49996129
107SIK10.49991930
108CDK60.49953957
109TESK20.49889029
110PDGFRB0.49594158
111ABL20.47190659
112PRKD10.46736588
113HIPK20.45874398
114CAMKK20.45686311
115SGK2230.45412038
116SGK4940.45412038
117LCK0.44697174
118ARAF0.42135918
119PTK2B0.41650379
120ABL10.41623845
121ROCK10.41248458
122PIK3CG0.41198204
123RPS6KA60.40979668
124SIK20.40145404
125MARK20.40144359
126GRK60.39844940
127TEC0.39541450
128FLT30.38903422
129LYN0.38493324
130PTK20.38451376
131RAF10.38139853
132CAMKK10.37635578
133EPHA30.37531446
134ITK0.33465927
135DYRK30.30829678
136STK240.29666876
137RPS6KA20.27991657
138FYN0.27213514
139DYRK1B0.25468869
140MAPKAPK20.25038864

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.55017077
2Allograft rejection_Homo sapiens_hsa053302.45372024
3Osteoclast differentiation_Homo sapiens_hsa043802.34511072
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19446487
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.17491633
6Malaria_Homo sapiens_hsa051442.02968446
7Autoimmune thyroid disease_Homo sapiens_hsa053201.90875928
8Tuberculosis_Homo sapiens_hsa051521.89379873
9TNF signaling pathway_Homo sapiens_hsa046681.86569595
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84369995
11Lysosome_Homo sapiens_hsa041421.77945865
12Pertussis_Homo sapiens_hsa051331.74519145
13Staphylococcus aureus infection_Homo sapiens_hsa051501.70120770
14Type I diabetes mellitus_Homo sapiens_hsa049401.69963254
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.69859120
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66469162
17Toxoplasmosis_Homo sapiens_hsa051451.46164221
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45508635
19Other glycan degradation_Homo sapiens_hsa005111.45486409
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44670305
21Legionellosis_Homo sapiens_hsa051341.43274259
22B cell receptor signaling pathway_Homo sapiens_hsa046621.40687014
23Salmonella infection_Homo sapiens_hsa051321.40369162
24Influenza A_Homo sapiens_hsa051641.39972919
25Apoptosis_Homo sapiens_hsa042101.38706227
26Antigen processing and presentation_Homo sapiens_hsa046121.37458688
27Rheumatoid arthritis_Homo sapiens_hsa053231.34710272
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.34165472
29Dilated cardiomyopathy_Homo sapiens_hsa054141.33246691
30Pancreatic cancer_Homo sapiens_hsa052121.33034907
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32486080
32Shigellosis_Homo sapiens_hsa051311.31925311
33Phagosome_Homo sapiens_hsa041451.30829502
34Chronic myeloid leukemia_Homo sapiens_hsa052201.29612716
35Hematopoietic cell lineage_Homo sapiens_hsa046401.28811638
36Dorso-ventral axis formation_Homo sapiens_hsa043201.27127404
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26846069
38Measles_Homo sapiens_hsa051621.25194205
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.23953099
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22691239
41Amoebiasis_Homo sapiens_hsa051461.22054982
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13438573
43Primary immunodeficiency_Homo sapiens_hsa053401.11923467
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.08989187
45Hepatitis B_Homo sapiens_hsa051611.08754944
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07476066
47Chemokine signaling pathway_Homo sapiens_hsa040621.07434561
48Viral myocarditis_Homo sapiens_hsa054161.05158786
49Platelet activation_Homo sapiens_hsa046111.04066366
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98290348
51Focal adhesion_Homo sapiens_hsa045100.97817971
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97622024
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97411359
54Prion diseases_Homo sapiens_hsa050200.97107053
55Hepatitis C_Homo sapiens_hsa051600.96641962
56Proteoglycans in cancer_Homo sapiens_hsa052050.96168428
57Acute myeloid leukemia_Homo sapiens_hsa052210.94084976
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.92238183
59Caffeine metabolism_Homo sapiens_hsa002320.92220410
60Bladder cancer_Homo sapiens_hsa052190.91177260
61African trypanosomiasis_Homo sapiens_hsa051430.90569398
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89926768
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.88417155
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.87939998
65Small cell lung cancer_Homo sapiens_hsa052220.87225228
66VEGF signaling pathway_Homo sapiens_hsa043700.87167822
67Insulin resistance_Homo sapiens_hsa049310.87089458
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86132100
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83317579
70Type II diabetes mellitus_Homo sapiens_hsa049300.80556786
71Prolactin signaling pathway_Homo sapiens_hsa049170.79822853
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77587089
73HIF-1 signaling pathway_Homo sapiens_hsa040660.76809894
74Mineral absorption_Homo sapiens_hsa049780.76337846
75Glioma_Homo sapiens_hsa052140.75441273
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72247160
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71830966
78Herpes simplex infection_Homo sapiens_hsa051680.70149669
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.69849922
80Sphingolipid metabolism_Homo sapiens_hsa006000.68120706
81Insulin signaling pathway_Homo sapiens_hsa049100.67715527
82ECM-receptor interaction_Homo sapiens_hsa045120.67301449
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66950818
84Epstein-Barr virus infection_Homo sapiens_hsa051690.66847229
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65403013
86mTOR signaling pathway_Homo sapiens_hsa041500.64816756
87Complement and coagulation cascades_Homo sapiens_hsa046100.62463402
88GnRH signaling pathway_Homo sapiens_hsa049120.61329152
89Non-small cell lung cancer_Homo sapiens_hsa052230.60902281
90FoxO signaling pathway_Homo sapiens_hsa040680.60474948
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60400978
92MAPK signaling pathway_Homo sapiens_hsa040100.59822713
93Asthma_Homo sapiens_hsa053100.58959122
94Renal cell carcinoma_Homo sapiens_hsa052110.58879222
95MicroRNAs in cancer_Homo sapiens_hsa052060.58725973
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.54644160
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54396748
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54173263
99T cell receptor signaling pathway_Homo sapiens_hsa046600.51902596
100Endocytosis_Homo sapiens_hsa041440.51741927
101Collecting duct acid secretion_Homo sapiens_hsa049660.51055622
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50637953
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49351555
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48801029
105Adherens junction_Homo sapiens_hsa045200.47830569
106Rap1 signaling pathway_Homo sapiens_hsa040150.47563196
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47499199
108Choline metabolism in cancer_Homo sapiens_hsa052310.45916353
109Graft-versus-host disease_Homo sapiens_hsa053320.44806255
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44693638
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44384950
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44113412
113HTLV-I infection_Homo sapiens_hsa051660.43068120
114Melanoma_Homo sapiens_hsa052180.41214488
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40802919
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40529254
117Notch signaling pathway_Homo sapiens_hsa043300.37774917
118Viral carcinogenesis_Homo sapiens_hsa052030.34477890
119Vibrio cholerae infection_Homo sapiens_hsa051100.32054080
120Galactose metabolism_Homo sapiens_hsa000520.21799946
121Systemic lupus erythematosus_Homo sapiens_hsa053220.19359598
122PPAR signaling pathway_Homo sapiens_hsa033200.18764554

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