AMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine metabolic process (GO:0006558)5.88230153
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.88230153
3L-phenylalanine catabolic process (GO:0006559)5.86153043
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.86153043
5aromatic amino acid family catabolic process (GO:0009074)5.50695555
6tryptophan catabolic process (GO:0006569)5.21222817
7indole-containing compound catabolic process (GO:0042436)5.21222817
8indolalkylamine catabolic process (GO:0046218)5.21222817
9* serine family amino acid catabolic process (GO:0009071)5.13202716
10* glycine metabolic process (GO:0006544)5.01436605
11tryptophan metabolic process (GO:0006568)4.92245056
12glyoxylate metabolic process (GO:0046487)4.86553753
13urea cycle (GO:0000050)4.68419704
14urea metabolic process (GO:0019627)4.68419704
15serine family amino acid biosynthetic process (GO:0009070)4.67357723
16bile acid biosynthetic process (GO:0006699)4.59662699
17kynurenine metabolic process (GO:0070189)4.59652271
18* serine family amino acid metabolic process (GO:0009069)4.54722393
19imidazole-containing compound metabolic process (GO:0052803)4.40776583
20sulfur amino acid catabolic process (GO:0000098)4.37743902
21nitrogen cycle metabolic process (GO:0071941)4.32094396
22cysteine metabolic process (GO:0006534)4.31810985
23aromatic amino acid family metabolic process (GO:0009072)4.23613068
24amine catabolic process (GO:0009310)4.19203176
25cellular biogenic amine catabolic process (GO:0042402)4.19203176
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.15581779
27* alpha-amino acid catabolic process (GO:1901606)4.12048392
28aldehyde catabolic process (GO:0046185)4.10049081
29omega-hydroxylase P450 pathway (GO:0097267)4.07383742
30bile acid metabolic process (GO:0008206)3.93173752
31protein complex biogenesis (GO:0070271)3.93021612
32regulation of fibrinolysis (GO:0051917)3.92716485
33regulation of gene silencing by RNA (GO:0060966)3.92340421
34regulation of posttranscriptional gene silencing (GO:0060147)3.92340421
35regulation of gene silencing by miRNA (GO:0060964)3.92340421
36* cellular amino acid catabolic process (GO:0009063)3.90003952
37amino-acid betaine metabolic process (GO:0006577)3.89820535
38homocysteine metabolic process (GO:0050667)3.87802524
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.87761631
40NADH dehydrogenase complex assembly (GO:0010257)3.87761631
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.87761631
42mitochondrial respiratory chain complex assembly (GO:0033108)3.84541021
43indolalkylamine metabolic process (GO:0006586)3.79517945
44water-soluble vitamin biosynthetic process (GO:0042364)3.76162649
45arginine metabolic process (GO:0006525)3.74634698
46L-serine metabolic process (GO:0006563)3.74448642
47high-density lipoprotein particle remodeling (GO:0034375)3.73486777
48regulation of cholesterol esterification (GO:0010872)3.70854842
49negative regulation of fibrinolysis (GO:0051918)3.64778025
50cellular modified amino acid catabolic process (GO:0042219)3.61922004
51cellular glucuronidation (GO:0052695)3.50983835
52tyrosine metabolic process (GO:0006570)3.50073851
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.47034363
54uronic acid metabolic process (GO:0006063)3.46482608
55glucuronate metabolic process (GO:0019585)3.46482608
56regulation of protein activation cascade (GO:2000257)3.46325378
57coenzyme catabolic process (GO:0009109)3.43649460
58urate metabolic process (GO:0046415)3.39408411
59exogenous drug catabolic process (GO:0042738)3.38133781
60arginine catabolic process (GO:0006527)3.34387660
61glutamate metabolic process (GO:0006536)3.34308713
62glutamine family amino acid biosynthetic process (GO:0009084)3.33913086
63NAD biosynthetic process (GO:0009435)3.30627929
64response to nitrosative stress (GO:0051409)3.27660431
65* organic acid catabolic process (GO:0016054)3.27617984
66* carboxylic acid catabolic process (GO:0046395)3.27617984
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26833892
68complement activation, alternative pathway (GO:0006957)3.25708906
69mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.25585271
70RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.25318901
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.25318901
72reverse cholesterol transport (GO:0043691)3.23593374
73respiratory chain complex IV assembly (GO:0008535)3.23134818
74ethanol oxidation (GO:0006069)3.22313165
75plasma lipoprotein particle remodeling (GO:0034369)3.22284843
76protein-lipid complex remodeling (GO:0034368)3.22284843
77macromolecular complex remodeling (GO:0034367)3.22284843
78mannosylation (GO:0097502)3.21533133
79proline metabolic process (GO:0006560)3.19664252
80low-density lipoprotein particle remodeling (GO:0034374)3.18613518
81ATP synthesis coupled proton transport (GO:0015986)3.18296477
82energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18296477
83regulation of complement activation (GO:0030449)3.17542748
84cellular ketone body metabolic process (GO:0046950)3.17337125
85regulation of bile acid biosynthetic process (GO:0070857)3.14454218
86fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.14359270
87lysine catabolic process (GO:0006554)3.11097710
88lysine metabolic process (GO:0006553)3.11097710
89protein carboxylation (GO:0018214)3.10353034
90peptidyl-glutamic acid carboxylation (GO:0017187)3.10353034
91benzene-containing compound metabolic process (GO:0042537)3.09867794
92L-ascorbic acid metabolic process (GO:0019852)3.09626038
93cytochrome complex assembly (GO:0017004)3.08916240
94branched-chain amino acid catabolic process (GO:0009083)3.08880035
95blood coagulation, intrinsic pathway (GO:0007597)3.07725222
96amino acid salvage (GO:0043102)3.07642389
97L-methionine salvage (GO:0071267)3.07642389
98L-methionine biosynthetic process (GO:0071265)3.07642389
99regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.03570423
100acylglycerol homeostasis (GO:0055090)3.01811177
101triglyceride homeostasis (GO:0070328)3.01811177
102sulfur amino acid biosynthetic process (GO:0000097)3.01026196
103establishment of protein localization to mitochondrial membrane (GO:0090151)2.99089082
104negative regulation of cholesterol transport (GO:0032375)2.96647877
105negative regulation of sterol transport (GO:0032372)2.96647877
106metallo-sulfur cluster assembly (GO:0031163)2.96606244
107iron-sulfur cluster assembly (GO:0016226)2.96606244
108regulation of triglyceride catabolic process (GO:0010896)2.93900720
109proteasome assembly (GO:0043248)2.93746427
110bile acid and bile salt transport (GO:0015721)2.93054747
111sulfur amino acid metabolic process (GO:0000096)2.91657117
112one-carbon metabolic process (GO:0006730)2.91508463
113drug catabolic process (GO:0042737)2.91473474
114somatic hypermutation of immunoglobulin genes (GO:0016446)2.91378212
115somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91378212
116pyridine nucleotide biosynthetic process (GO:0019363)2.91248392
117nicotinamide nucleotide biosynthetic process (GO:0019359)2.91248392
118folic acid metabolic process (GO:0046655)2.90346890
119ribosomal small subunit assembly (GO:0000028)2.89962152
120alpha-linolenic acid metabolic process (GO:0036109)2.89614492
121S-adenosylmethionine metabolic process (GO:0046500)2.89023068
122epithelial cilium movement (GO:0003351)2.88159151
123positive regulation of cellular amine metabolic process (GO:0033240)2.87968956
124tetrahydrofolate metabolic process (GO:0046653)2.87920807
125L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87764684
126base-excision repair, AP site formation (GO:0006285)2.86886899
127very-low-density lipoprotein particle assembly (GO:0034379)2.85357578
128* small molecule catabolic process (GO:0044282)2.83207752
129pyrimidine nucleotide catabolic process (GO:0006244)2.82547810
130regulation of non-canonical Wnt signaling pathway (GO:2000050)2.80434445
131ketone body metabolic process (GO:1902224)2.79216649
132phospholipid efflux (GO:0033700)2.79052778
133mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78915300
134heme transport (GO:0015886)2.77326182
135indole-containing compound metabolic process (GO:0042430)2.76962125
136drug transmembrane transport (GO:0006855)2.76165115
137branched-chain amino acid metabolic process (GO:0009081)2.75438937
138photoreceptor cell maintenance (GO:0045494)2.75236777
139behavioral response to nicotine (GO:0035095)2.73190325
140rRNA modification (GO:0000154)2.71987232
141glutamine family amino acid metabolic process (GO:0009064)2.71935856
142platelet dense granule organization (GO:0060155)2.70765581
143nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70665583
144regulation of mitotic spindle checkpoint (GO:1903504)2.69411929
145regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69411929
146chaperone-mediated protein transport (GO:0072321)2.67830159
147short-chain fatty acid metabolic process (GO:0046459)2.66994944
148regulation of cholesterol metabolic process (GO:0090181)2.66949361
149chromatin remodeling at centromere (GO:0031055)2.65871010
150oxidative demethylation (GO:0070989)2.65281364
151DNA deamination (GO:0045006)2.64899920
152vitamin biosynthetic process (GO:0009110)2.57501724
153exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.55114200
154peptidyl-histidine modification (GO:0018202)2.54999040
155pseudouridine synthesis (GO:0001522)2.54433200
156quinone biosynthetic process (GO:1901663)2.52277586
157deoxyribonucleotide catabolic process (GO:0009264)2.52136818
158epoxygenase P450 pathway (GO:0019373)2.51931207
159nephron epithelium morphogenesis (GO:0072088)2.49994098
160nephron tubule morphogenesis (GO:0072078)2.49994098
161seminiferous tubule development (GO:0072520)2.49923504
162ubiquinone biosynthetic process (GO:0006744)2.47827440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.98993539
2EGR1_23403033_ChIP-Seq_LIVER_Mouse4.54686664
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.14398343
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.10926902
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.54276288
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.39316283
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.25593719
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.25593719
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.25593719
10ZNF274_21170338_ChIP-Seq_K562_Hela3.23521031
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13406419
12E2F7_22180533_ChIP-Seq_HELA_Human3.10779569
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.81798412
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.79431042
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.77542708
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.66696653
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59920922
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57045241
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50044217
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.29903831
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29854023
22POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.19382657
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12721229
24VDR_22108803_ChIP-Seq_LS180_Human2.12229635
25* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.11367061
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10466953
27TCF3_18692474_ChIP-Seq_MEFs_Mouse2.10096562
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09168102
29EST1_17652178_ChIP-ChIP_JURKAT_Human2.04603443
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02687297
31IRF1_19129219_ChIP-ChIP_H3396_Human2.02556105
32MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00614148
33SOX2_18555785_ChIP-Seq_MESCs_Mouse1.97152237
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94196595
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89630863
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.88841012
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86212122
38* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.81191527
39* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.81188378
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81104739
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76393105
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.75850773
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.72929074
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72659229
45SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.71376782
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70118511
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.66587643
48FUS_26573619_Chip-Seq_HEK293_Human1.63565197
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63152280
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62270931
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62092466
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61697675
53SOX2_18692474_ChIP-Seq_MEFs_Mouse1.60511509
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57082935
55IGF1R_20145208_ChIP-Seq_DFB_Human1.54705712
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54055135
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.49802144
58EWS_26573619_Chip-Seq_HEK293_Human1.48098338
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44613202
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44394674
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.44238974
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43240002
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36189953
64* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35237602
65KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32940796
66TP53_22573176_ChIP-Seq_HFKS_Human1.30984424
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30720824
68* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28734768
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28725675
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28584062
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.28570439
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28549321
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27943673
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.27342572
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26576812
76OCT4_18692474_ChIP-Seq_MEFs_Mouse1.23765703
77* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22951231
78POU5F1_16518401_ChIP-PET_MESCs_Mouse1.22115439
79NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22047414
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21977451
81* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21310505
82NANOG_20526341_ChIP-Seq_ESCs_Human1.19942077
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19500701
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19317296
85* ERA_21632823_ChIP-Seq_H3396_Human1.17361047
86ELK1_19687146_ChIP-ChIP_HELA_Human1.17159334
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.16823856
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16823856
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16502068
90XRN2_22483619_ChIP-Seq_HELA_Human1.15958365
91ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15163812
92DCP1A_22483619_ChIP-Seq_HELA_Human1.14947276
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13832616
94MYC_19829295_ChIP-Seq_ESCs_Human1.12879821
95* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12408017
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11411520
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10658413
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09962908
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.09079301
100YY1_22570637_ChIP-Seq_MALME-3M_Human1.08179934
101NANOG_19829295_ChIP-Seq_ESCs_Human1.06904478
102SOX2_19829295_ChIP-Seq_ESCs_Human1.06904478
103AR_20517297_ChIP-Seq_VCAP_Human1.06589808
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06427193
105MYC_18940864_ChIP-ChIP_HL60_Human1.05721143
106EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05552763
107P300_19829295_ChIP-Seq_ESCs_Human1.03898615
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03346660
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01659006
110* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00549008
111P53_21459846_ChIP-Seq_SAOS-2_Human1.00141550
112MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98551041
113FOXP1_21924763_ChIP-Seq_HESCs_Human0.97832798
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97128653
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.96983867
116TAF15_26573619_Chip-Seq_HEK293_Human0.96837045
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96224647
118FOXP3_21729870_ChIP-Seq_TREG_Human0.96212631
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95557160
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92961322
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91975705
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91372418
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91208323
124* TTF2_22483619_ChIP-Seq_HELA_Human0.90946099
125AR_21909140_ChIP-Seq_LNCAP_Human0.90739871
126TP63_19390658_ChIP-ChIP_HaCaT_Human0.90623099
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89696417
128* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.87858411
129CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87513278
130VDR_23849224_ChIP-Seq_CD4+_Human0.86692053
131NCOR_22424771_ChIP-Seq_293T_Human0.85813919
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.85752808
133RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85079620
134SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84523772
135RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84200219
136HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83118352
137OCT4_20526341_ChIP-Seq_ESCs_Human0.82658307
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82159245
139FOXH1_21741376_ChIP-Seq_EPCs_Human0.82085863
140TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82022558
141BCAT_22108803_ChIP-Seq_LS180_Human0.81822128
142CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81703906
143SOX17_20123909_ChIP-Seq_XEN_Mouse0.80737905
144KAP1_27257070_Chip-Seq_ESCs_Mouse0.80172403
145PHF8_20622854_ChIP-Seq_HELA_Human0.79721885
146HTT_18923047_ChIP-ChIP_STHdh_Human0.79320588
147KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78106248
148CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.74068705
149GABP_19822575_ChIP-Seq_HepG2_Human0.72955608
150STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.72946698
151NANOG_16518401_ChIP-PET_MESCs_Mouse0.72690516
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72484351
153NFE2_27457419_Chip-Seq_LIVER_Mouse0.71824018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.03050059
2MP0005360_urolithiasis5.50560549
3MP0005085_abnormal_gallbladder_physiolo4.73501633
4MP0003806_abnormal_nucleotide_metabolis4.67102533
5MP0005365_abnormal_bile_salt4.14646060
6MP0003136_yellow_coat_color3.64573266
7MP0008875_abnormal_xenobiotic_pharmacok3.49163762
8MP0003122_maternal_imprinting2.81852461
9MP0005332_abnormal_amino_acid2.79173614
10MP0006292_abnormal_olfactory_placode2.74796931
11MP0000566_synostosis2.47609708
12MP0008877_abnormal_DNA_methylation2.46268870
13MP0004019_abnormal_vitamin_homeostasis2.42696487
14MP0003787_abnormal_imprinting2.39415094
15MP0003718_maternal_effect2.30488905
16MP0003011_delayed_dark_adaptation2.27621683
17MP0003252_abnormal_bile_duct2.22978341
18MP0003878_abnormal_ear_physiology2.14036085
19MP0005377_hearing/vestibular/ear_phenot2.14036085
20MP0004381_abnormal_hair_follicle2.11215659
21MP0002938_white_spotting2.04363724
22MP0009379_abnormal_foot_pigmentation2.02268385
23MP0003195_calcinosis2.01865819
24MP0004147_increased_porphyrin_level1.92721976
25MP0010329_abnormal_lipoprotein_level1.90086714
26MP0005083_abnormal_biliary_tract1.81953727
27MP0003121_genomic_imprinting1.79288989
28MP0001984_abnormal_olfaction1.71805225
29MP0001764_abnormal_homeostasis1.70558171
30MP0003186_abnormal_redox_activity1.68369252
31MP0002653_abnormal_ependyma_morphology1.63631979
32MP0009840_abnormal_foam_cell1.62504710
33MP0005408_hypopigmentation1.60870413
34MP0002254_reproductive_system_inflammat1.59611824
35MP0003315_abnormal_perineum_morphology1.57803029
36MP0001188_hyperpigmentation1.49271808
37MP0002102_abnormal_ear_morphology1.48902503
38MP0009053_abnormal_anal_canal1.48700630
39MP0008872_abnormal_physiological_respon1.45677369
40MP0006072_abnormal_retinal_apoptosis1.42735121
41MP0001666_abnormal_nutrient_absorption1.41751125
42MP0002837_dystrophic_cardiac_calcinosis1.41083892
43MP0003567_abnormal_fetal_cardiomyocyte1.39084770
44MP0005646_abnormal_pituitary_gland1.38132863
45MP0003693_abnormal_embryo_hatching1.35189497
46MP0002249_abnormal_larynx_morphology1.34091569
47MP0003868_abnormal_feces_composition1.33551926
48MP0005075_abnormal_melanosome_morpholog1.33237710
49MP0000372_irregular_coat_pigmentation1.31377924
50MP0009697_abnormal_copulation1.30101732
51MP0001986_abnormal_taste_sensitivity1.29866938
52MP0005409_darkened_coat_color1.24846506
53MP0002822_catalepsy1.22809177
54MP0005647_abnormal_sex_gland1.22218234
55MP0003880_abnormal_central_pattern1.22097939
56MP0002876_abnormal_thyroid_physiology1.21220535
57MP0004133_heterotaxia1.18904244
58MP0002160_abnormal_reproductive_system1.18305528
59MP0005319_abnormal_enzyme/_coenzyme1.15932948
60MP0003938_abnormal_ear_development1.14931352
61MP0000049_abnormal_middle_ear1.12789986
62MP0005410_abnormal_fertilization1.12727405
63MP0005253_abnormal_eye_physiology1.11868479
64MP0008789_abnormal_olfactory_epithelium1.10610787
65MP0001968_abnormal_touch/_nociception1.10568692
66MP0003119_abnormal_digestive_system1.07782582
67MP0008995_early_reproductive_senescence1.07646038
68MP0005645_abnormal_hypothalamus_physiol1.07628068
69MP0002736_abnormal_nociception_after1.07488505
70MP0000609_abnormal_liver_physiology1.05568535
71MP0002138_abnormal_hepatobiliary_system1.04753662
72MP0003786_premature_aging1.03949262
73MP0005084_abnormal_gallbladder_morpholo1.03460309
74MP0005499_abnormal_olfactory_system1.02034457
75MP0005394_taste/olfaction_phenotype1.02034457
76MP0002118_abnormal_lipid_homeostasis1.00307075
77MP0001919_abnormal_reproductive_system0.99354323
78MP0006276_abnormal_autonomic_nervous0.99310947
79MP0003890_abnormal_embryonic-extraembry0.99010814
80MP0005451_abnormal_body_composition0.98124093
81MP0002751_abnormal_autonomic_nervous0.96928788
82MP0002638_abnormal_pupillary_reflex0.96927347
83MP0008058_abnormal_DNA_repair0.96438967
84MP0004043_abnormal_pH_regulation0.96025675
85MP0005395_other_phenotype0.92701453
86MP0008260_abnormal_autophagy0.91861313
87MP0009384_cardiac_valve_regurgitation0.91083822
88MP0005389_reproductive_system_phenotype0.90109020
89MP0001529_abnormal_vocalization0.89724422
90MP0009643_abnormal_urine_homeostasis0.89095245
91MP0003111_abnormal_nucleus_morphology0.89030880
92MP0002928_abnormal_bile_duct0.88562090
93MP0002234_abnormal_pharynx_morphology0.86587745
94MP0003646_muscle_fatigue0.85911955
95MP0005174_abnormal_tail_pigmentation0.85669764
96MP0008932_abnormal_embryonic_tissue0.85434226
97MP0003941_abnormal_skin_development0.84536538
98MP0004142_abnormal_muscle_tone0.83810578
99MP0001324_abnormal_eye_pigmentation0.81068511
100MP0001286_abnormal_eye_development0.79483169
101MP0001929_abnormal_gametogenesis0.78935947
102MP0005195_abnormal_posterior_eye0.78461852
103MP0000613_abnormal_salivary_gland0.78139696
104MP0005266_abnormal_metabolism0.77692463
105MP0010094_abnormal_chromosome_stability0.77271422
106MP0001486_abnormal_startle_reflex0.77182928
107MP0005636_abnormal_mineral_homeostasis0.77158869
108MP0002233_abnormal_nose_morphology0.76959592
109MP0003698_abnormal_male_reproductive0.75767259
110MP0004957_abnormal_blastocyst_morpholog0.75172735
111MP0006036_abnormal_mitochondrial_physio0.74575819
112MP0010030_abnormal_orbit_morphology0.73594601
113MP0000026_abnormal_inner_ear0.71885471
114MP0009672_abnormal_birth_weight0.71399854
115MP0005391_vision/eye_phenotype0.70143405
116MP0003937_abnormal_limbs/digits/tail_de0.69800616
117MP0000653_abnormal_sex_gland0.69472346
118MP0000467_abnormal_esophagus_morphology0.69173646
119MP0002132_abnormal_respiratory_system0.68954324
120MP0002272_abnormal_nervous_system0.68877350
121MP0005376_homeostasis/metabolism_phenot0.68551221
122MP0002557_abnormal_social/conspecific_i0.68306690
123MP0001119_abnormal_female_reproductive0.67889698
124MP0008007_abnormal_cellular_replicative0.67198665
125MP0001293_anophthalmia0.66866724
126MP0005584_abnormal_enzyme/coenzyme_acti0.66758757
127MP0001145_abnormal_male_reproductive0.65937228
128MP0009765_abnormal_xenobiotic_induced0.65811048
129MP0002277_abnormal_respiratory_mucosa0.65149659
130MP0003936_abnormal_reproductive_system0.65136909
131MP0001963_abnormal_hearing_physiology0.64437614
132MP0000678_abnormal_parathyroid_gland0.63400820
133MP0001756_abnormal_urination0.62955852
134MP0001485_abnormal_pinna_reflex0.60830486
135MP0002111_abnormal_tail_morphology0.59935411
136MP0000598_abnormal_liver_morphology0.59097779
137MP0006035_abnormal_mitochondrial_morpho0.57874079
138MP0005551_abnormal_eye_electrophysiolog0.57260190
139MP0000579_abnormal_nail_morphology0.57032555
140MP0000631_abnormal_neuroendocrine_gland0.56673274
141MP0002177_abnormal_outer_ear0.55897368
142MP0002098_abnormal_vibrissa_morphology0.54949031
143MP0005248_abnormal_Harderian_gland0.52962662
144MP0000762_abnormal_tongue_morphology0.52682694
145MP0003699_abnormal_female_reproductive0.52592949
146MP0001661_extended_life_span0.52538092

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)5.62887828
2Intrahepatic cholestasis (HP:0001406)5.27280441
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.18014130
4Prolonged partial thromboplastin time (HP:0003645)5.09039917
5Abnormality of pyrimidine metabolism (HP:0004353)4.55456624
6* Hyperglycinemia (HP:0002154)4.15439638
7Hypobetalipoproteinemia (HP:0003563)4.14989734
8* Hyperglycinuria (HP:0003108)3.98818701
9* Abnormality of serine family amino acid metabolism (HP:0010894)3.61845061
10* Abnormality of glycine metabolism (HP:0010895)3.61845061
11Abnormality of methionine metabolism (HP:0010901)3.45059284
12Hyperammonemia (HP:0001987)3.35414423
13Abnormality of aspartate family amino acid metabolism (HP:0010899)3.33189135
14Xanthomatosis (HP:0000991)3.29505549
15Deep venous thrombosis (HP:0002625)3.29421606
16Joint hemorrhage (HP:0005261)3.26672168
17Abnormality of glutamine family amino acid metabolism (HP:0010902)3.25374386
18Abnormality of sulfur amino acid metabolism (HP:0004339)3.13313898
19Pancreatic fibrosis (HP:0100732)3.13089455
20True hermaphroditism (HP:0010459)3.09595995
21Acute necrotizing encephalopathy (HP:0006965)3.08353599
22Colon cancer (HP:0003003)3.06847362
23Pancreatic cysts (HP:0001737)3.04241634
24Abnormality of the labia minora (HP:0012880)3.03928378
25Hepatocellular necrosis (HP:0001404)3.00104484
26Delayed CNS myelination (HP:0002188)2.97055816
27Mitochondrial inheritance (HP:0001427)2.91861084
28* Abnormality of serum amino acid levels (HP:0003112)2.91069008
29Medial flaring of the eyebrow (HP:0010747)2.87769572
30Fat malabsorption (HP:0002630)2.85855131
31Hyperlipoproteinemia (HP:0010980)2.82559180
32* Lethargy (HP:0001254)2.81047843
33Abnormal mitochondria in muscle tissue (HP:0008316)2.76183676
34Hypolipoproteinemia (HP:0010981)2.75353953
35Cerebral edema (HP:0002181)2.70652406
36Complement deficiency (HP:0004431)2.69949566
37Abnormality of midbrain morphology (HP:0002418)2.68004433
38Molar tooth sign on MRI (HP:0002419)2.68004433
39Ketosis (HP:0001946)2.63945037
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62413106
41Abnormality of nucleobase metabolism (HP:0010932)2.60741425
42Increased CSF lactate (HP:0002490)2.59888298
43Nephronophthisis (HP:0000090)2.59450818
44Methylmalonic acidemia (HP:0002912)2.58802064
45Abnormal number of erythroid precursors (HP:0012131)2.58214060
46Abnormality of the axillary hair (HP:0100134)2.51839397
47Abnormality of secondary sexual hair (HP:0009888)2.51839397
48Hypoglycemic coma (HP:0001325)2.51632125
49Spontaneous abortion (HP:0005268)2.51559033
50Conjugated hyperbilirubinemia (HP:0002908)2.47642623
51Progressive external ophthalmoplegia (HP:0000590)2.47390576
52Progressive macrocephaly (HP:0004481)2.45812654
53Epidermoid cyst (HP:0200040)2.42616759
54Glycosuria (HP:0003076)2.42090023
55Abnormality of urine glucose concentration (HP:0011016)2.42090023
56Reticulocytopenia (HP:0001896)2.41555224
57Cerebral palsy (HP:0100021)2.40958641
58Alkalosis (HP:0001948)2.39388015
59Congenital primary aphakia (HP:0007707)2.38435880
60Type I transferrin isoform profile (HP:0003642)2.36770147
613-Methylglutaconic aciduria (HP:0003535)2.36643019
62Abnormality of cells of the erythroid lineage (HP:0012130)2.35978321
63Methylmalonic aciduria (HP:0012120)2.35920715
64Microvesicular hepatic steatosis (HP:0001414)2.34387685
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.33810738
66Chronic hepatic failure (HP:0100626)2.33768887
67Gait imbalance (HP:0002141)2.33462300
68Increased hepatocellular lipid droplets (HP:0006565)2.31585035
69Nephrogenic diabetes insipidus (HP:0009806)2.31259677
70Congenital stationary night blindness (HP:0007642)2.30675055
71Reduced antithrombin III activity (HP:0001976)2.28619554
72Abolished electroretinogram (ERG) (HP:0000550)2.26607391
73Cystic liver disease (HP:0006706)2.25841772
74Dicarboxylic aciduria (HP:0003215)2.23576688
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23576688
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22544937
77Malnutrition (HP:0004395)2.22502769
78Steatorrhea (HP:0002570)2.21977212
79Pseudobulbar signs (HP:0002200)2.21430771
80Abnormality of fatty-acid metabolism (HP:0004359)2.21083519
81Hypophosphatemic rickets (HP:0004912)2.20585096
82Hyperbilirubinemia (HP:0002904)2.20272355
83Supernumerary spleens (HP:0009799)2.18851508
84Optic disc pallor (HP:0000543)2.17323460
85Megaloblastic anemia (HP:0001889)2.16252062
86Aplasia/Hypoplasia involving the musculature (HP:0001460)2.15440824
87Abnormality of the renal medulla (HP:0100957)2.15031758
88Breast hypoplasia (HP:0003187)2.14399936
89Osteomalacia (HP:0002749)2.13665165
90Vaginal atresia (HP:0000148)2.12653210
91Rickets (HP:0002748)2.12518364
92Abnormality of the common coagulation pathway (HP:0010990)2.12253783
93Gout (HP:0001997)2.12072674
94Decreased central vision (HP:0007663)2.11908843
95Hyperphosphaturia (HP:0003109)2.10799421
96Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10299625
97Genital tract atresia (HP:0001827)2.09227821
98Enlarged kidneys (HP:0000105)2.08611858
99Hypoalphalipoproteinemia (HP:0003233)2.06826540
100Dry hair (HP:0011359)2.02594891
101Congenital hepatic fibrosis (HP:0002612)2.01991630
102Occipital encephalocele (HP:0002085)2.01982318
103Bile duct proliferation (HP:0001408)2.01865028
104Abnormal biliary tract physiology (HP:0012439)2.01865028
105Renal Fanconi syndrome (HP:0001994)2.00295563
106Meckel diverticulum (HP:0002245)1.99845324
107Hypochromic microcytic anemia (HP:0004840)1.99660202
108Proximal tubulopathy (HP:0000114)1.98584950
109Anophthalmia (HP:0000528)1.97203096
110Bilateral microphthalmos (HP:0007633)1.96234006
111Abnormal sex determination (HP:0012244)1.96044848
112Sex reversal (HP:0012245)1.96044848
113Abnormality of complement system (HP:0005339)1.95733068
114Generalized aminoaciduria (HP:0002909)1.95170543
115Lactic acidosis (HP:0003128)1.93862765
116Abnormality of the ileum (HP:0001549)1.92548524
117Confusion (HP:0001289)1.92473808
118Abnormality of the renal cortex (HP:0011035)1.91182676
119Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90587772
120Aplasia/hypoplasia of the uterus (HP:0008684)1.90463996
121Poor coordination (HP:0002370)1.90106083
122Hepatic necrosis (HP:0002605)1.89885907
123Rib fusion (HP:0000902)1.89696455
124Opisthotonus (HP:0002179)1.89397663
125Renal cortical cysts (HP:0000803)1.87647460
126Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86960029
127Hypoglycemic seizures (HP:0002173)1.85811960
128Increased serum lactate (HP:0002151)1.85555125
129Absent radius (HP:0003974)1.85471088
130Hyperinsulinemic hypoglycemia (HP:0000825)1.85421666
131* Irritability (HP:0000737)1.85205206
132Abnormal urine phosphate concentration (HP:0012599)1.84241128
133Increased intramyocellular lipid droplets (HP:0012240)1.83979649
134Broad foot (HP:0001769)1.83933705
135Metabolic acidosis (HP:0001942)1.83371363
136Acute encephalopathy (HP:0006846)1.83086386
137Attenuation of retinal blood vessels (HP:0007843)1.81845823
138Vomiting (HP:0002013)1.81621552
139Aplasia involving forearm bones (HP:0009822)1.81136679
140Absent forearm bone (HP:0003953)1.81136679
141Macrocytic anemia (HP:0001972)1.80768592
142Abnormal respiratory epithelium morphology (HP:0012253)1.80600890
143Abnormal respiratory motile cilium morphology (HP:0005938)1.80600890
144Abnormal protein glycosylation (HP:0012346)1.78883452
145Abnormal glycosylation (HP:0012345)1.78883452
146Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78883452
147Abnormal protein N-linked glycosylation (HP:0012347)1.78883452
148Testicular atrophy (HP:0000029)1.78753092
149Hepatoblastoma (HP:0002884)1.78058772
150Prolonged neonatal jaundice (HP:0006579)1.77402600
151Lipid accumulation in hepatocytes (HP:0006561)1.76802495
152Split foot (HP:0001839)1.76754015
153Renal tubular dysfunction (HP:0000124)1.76401795
154Hypercholesterolemia (HP:0003124)1.76253533
155Rectal fistula (HP:0100590)1.76218611
156Rectovaginal fistula (HP:0000143)1.76218611
157Increased muscle lipid content (HP:0009058)1.75640986
158Septo-optic dysplasia (HP:0100842)1.73825096
159Type 2 muscle fiber atrophy (HP:0003554)1.72098304
160Dynein arm defect of respiratory motile cilia (HP:0012255)1.71548390
161Absent/shortened dynein arms (HP:0200106)1.71548390
162Ketoacidosis (HP:0001993)1.71335247
163Male pseudohermaphroditism (HP:0000037)1.70363273
164Abnormality of the heme biosynthetic pathway (HP:0010472)1.70202687
165Aplasia/Hypoplasia of the spleen (HP:0010451)1.68716443
166Sclerocornea (HP:0000647)1.68706916
167Cerebellar dysplasia (HP:0007033)1.67891388

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.75354601
2CASK4.45829550
3MKNK24.25087592
4AKT34.11303824
5VRK23.51637222
6BCKDK3.21065634
7SRPK13.19949190
8MKNK12.83688312
9NUAK12.79524860
10MAP4K22.53772138
11STK38L2.42968853
12BMPR1B2.34605720
13IRAK32.23684548
14PRPF4B2.21876604
15FRK2.14934491
16STK162.09197624
17WEE12.08784331
18TIE12.08014359
19CDK192.07231804
20EPHA22.03130970
21BUB12.02786323
22EIF2AK12.00722557
23TNIK1.87750689
24ZAK1.81315008
25FGFR21.79728432
26TAF11.76351683
27TRIM281.65927528
28KDR1.53085163
29MAP3K41.50022270
30EIF2AK31.48288544
31ERBB41.43329074
32PINK11.41481975
33EIF2AK21.37592349
34YES11.37078920
35TSSK61.34897710
36NME21.31112808
37PLK41.30675788
38TAOK31.28811891
39BRAF1.23898340
40TTK1.21441239
41WNK31.17688929
42KIT1.15009804
43MAPK151.11266703
44INSRR1.10799606
45SGK21.10617846
46VRK11.09910739
47STK381.09446256
48TEC1.08351637
49MAPKAPK51.06580601
50AURKA1.04605546
51PLK11.02456666
52IRAK20.98891876
53TNK20.97647600
54PBK0.97343735
55NEK60.94137421
56PASK0.91583648
57CDK70.90003040
58PLK30.89256361
59NLK0.86758207
60PRKD20.82532265
61SGK4940.80737308
62SGK2230.80737308
63IRAK10.80251507
64DYRK20.78626200
65MAPK110.78447113
66GRK10.78320977
67PIK3CA0.76579857
68BRSK20.75077884
69CSNK1G10.74716679
70RPS6KA50.72912023
71MAP2K40.72388069
72PRKCI0.71307747
73MAPK130.70661407
74MAP3K70.69478861
75CHEK20.69323610
76NEK20.67705000
77CLK10.67086621
78TESK20.64538548
79OXSR10.62024197
80PKN10.61111177
81CSNK2A10.59831787
82ATM0.58162326
83TGFBR10.57584736
84ACVR1B0.57091794
85BMPR20.55982286
86ADRBK20.55188965
87CAMK2G0.54727776
88CSNK2A20.53884856
89PRKCQ0.53285781
90PIM20.53033276
91MAP3K110.50712109
92ITK0.50280032
93TAOK20.50271417
94NEK10.50096710
95AURKB0.48750366
96DYRK1A0.48650159
97MAP2K60.48509891
98FGFR10.48465684
99NTRK20.48328193
100PRKCE0.47351664
101DYRK30.47329389
102LATS10.46880766
103BMX0.45566660
104OBSCN0.45113084
105MST40.44960097
106PNCK0.44546603
107CSNK1G20.43315801
108FLT30.43179591
109ADRBK10.42157903
110MATK0.39951694
111CAMK2B0.39748051
112IRAK40.39510005
113DAPK30.39110936
114DYRK1B0.37860106
115MAP2K70.37292426
116SGK30.36614326
117CSNK1G30.36467517
118PRKDC0.36452513
119CSNK1D0.35334008
120PIK3CG0.35294007
121PDK20.35258665
122DAPK20.35179916
123PRKCZ0.34778349
124CAMK10.34719542
125PRKCG0.33959919
126IKBKB0.33662523
127WNK40.33650515
128EPHA40.33588107
129PAK30.33255627
130PRKACG0.33034785
131CSNK1A10.32288824
132RPS6KB20.31946176
133MUSK0.31812611
134PRKCA0.31802589
135CDK30.30987363
136CDK20.30664062
137CSNK1E0.30351882
138CDK40.30083148
139CAMK40.28803781
140PRKAA20.28040890
141NME10.27871928
142MET0.27835428
143ATR0.27305270
144ERBB20.26581861
145CDC70.26576137
146PRKACA0.26317171
147MAP2K20.26241538
148GRK70.25842967
149MAPK70.25832455
150GSK3A0.24918581
151PIM10.23207779

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.48376078
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.69002362
3* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67275407
4Nitrogen metabolism_Homo sapiens_hsa009102.60103771
5Arginine biosynthesis_Homo sapiens_hsa002202.45974851
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30375624
7* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30247392
8Tryptophan metabolism_Homo sapiens_hsa003802.10073311
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.08716529
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.08577297
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04823741
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.02083135
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00889755
14Peroxisome_Homo sapiens_hsa041461.96434787
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.95028218
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.88441282
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.86597203
18Folate biosynthesis_Homo sapiens_hsa007901.82334908
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78751790
20Complement and coagulation cascades_Homo sapiens_hsa046101.78635624
21Chemical carcinogenesis_Homo sapiens_hsa052041.77774879
22Fatty acid degradation_Homo sapiens_hsa000711.77509967
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75095983
24Retinol metabolism_Homo sapiens_hsa008301.74183249
25Butanoate metabolism_Homo sapiens_hsa006501.73580041
26Selenocompound metabolism_Homo sapiens_hsa004501.71590496
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68418673
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.67287538
29Sulfur relay system_Homo sapiens_hsa041221.66442380
30* One carbon pool by folate_Homo sapiens_hsa006701.62991397
31Histidine metabolism_Homo sapiens_hsa003401.61366223
32beta-Alanine metabolism_Homo sapiens_hsa004101.60909747
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.58506101
34Propanoate metabolism_Homo sapiens_hsa006401.48795686
35Ribosome_Homo sapiens_hsa030101.44398123
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.43659171
37Phenylalanine metabolism_Homo sapiens_hsa003601.40802015
38Tyrosine metabolism_Homo sapiens_hsa003501.38085328
39Biosynthesis of amino acids_Homo sapiens_hsa012301.36957705
40RNA polymerase_Homo sapiens_hsa030201.32992670
41Vitamin B6 metabolism_Homo sapiens_hsa007501.29872088
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29734036
43Arginine and proline metabolism_Homo sapiens_hsa003301.29671504
44DNA replication_Homo sapiens_hsa030301.27455647
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27066349
46Fatty acid elongation_Homo sapiens_hsa000621.26910285
47Non-homologous end-joining_Homo sapiens_hsa034501.26789590
48Mismatch repair_Homo sapiens_hsa034301.25738543
49Sulfur metabolism_Homo sapiens_hsa009201.21721532
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16853950
51Fatty acid metabolism_Homo sapiens_hsa012121.13346851
52Pyrimidine metabolism_Homo sapiens_hsa002401.09764962
53Glutathione metabolism_Homo sapiens_hsa004801.09492529
54Vitamin digestion and absorption_Homo sapiens_hsa049771.08239700
55Homologous recombination_Homo sapiens_hsa034401.07760608
56Steroid biosynthesis_Homo sapiens_hsa001001.05937037
57PPAR signaling pathway_Homo sapiens_hsa033201.02922169
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02311296
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01734858
60Pyruvate metabolism_Homo sapiens_hsa006201.00435608
61RNA degradation_Homo sapiens_hsa030180.97585001
62Starch and sucrose metabolism_Homo sapiens_hsa005000.97561989
63Fanconi anemia pathway_Homo sapiens_hsa034600.92476093
64* Carbon metabolism_Homo sapiens_hsa012000.92325308
65Ether lipid metabolism_Homo sapiens_hsa005650.90150063
66Bile secretion_Homo sapiens_hsa049760.88573722
67* Metabolic pathways_Homo sapiens_hsa011000.79633827
68Fat digestion and absorption_Homo sapiens_hsa049750.76009839
69Alzheimers disease_Homo sapiens_hsa050100.75192595
70Spliceosome_Homo sapiens_hsa030400.74746125
71Pentose phosphate pathway_Homo sapiens_hsa000300.73412556
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73324715
73Nucleotide excision repair_Homo sapiens_hsa034200.72993229
74Proteasome_Homo sapiens_hsa030500.72446035
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71802426
76Cardiac muscle contraction_Homo sapiens_hsa042600.68451283
77Staphylococcus aureus infection_Homo sapiens_hsa051500.67934716
78ABC transporters_Homo sapiens_hsa020100.66910219
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65728479
80Fructose and mannose metabolism_Homo sapiens_hsa000510.64575715
81Arachidonic acid metabolism_Homo sapiens_hsa005900.63842878
82Base excision repair_Homo sapiens_hsa034100.62847075
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62785997
84Caffeine metabolism_Homo sapiens_hsa002320.62471473
85Purine metabolism_Homo sapiens_hsa002300.56463301
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55621940
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55600921
88Protein export_Homo sapiens_hsa030600.55438435
89Oxidative phosphorylation_Homo sapiens_hsa001900.55374825
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55133885
91Lysine degradation_Homo sapiens_hsa003100.54927249
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54035483
93Basal transcription factors_Homo sapiens_hsa030220.52119740
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.51675793
95RNA transport_Homo sapiens_hsa030130.49427211
96Galactose metabolism_Homo sapiens_hsa000520.48141329
97Taste transduction_Homo sapiens_hsa047420.46833008
98Linoleic acid metabolism_Homo sapiens_hsa005910.43901771
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43683482
100Systemic lupus erythematosus_Homo sapiens_hsa053220.40830415
101Mineral absorption_Homo sapiens_hsa049780.40794581
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39661379
103Huntingtons disease_Homo sapiens_hsa050160.39116708
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38761801
105Basal cell carcinoma_Homo sapiens_hsa052170.38238191
106Glycerolipid metabolism_Homo sapiens_hsa005610.34181260
107Phototransduction_Homo sapiens_hsa047440.29107242
108Regulation of autophagy_Homo sapiens_hsa041400.29027291
109Parkinsons disease_Homo sapiens_hsa050120.27981165
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25490847
111Prion diseases_Homo sapiens_hsa050200.23327721
112Thyroid cancer_Homo sapiens_hsa052160.21962660

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »