AMY1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.81791856
2regulation of cilium movement (GO:0003352)8.19943697
3left/right pattern formation (GO:0060972)6.76971996
4left/right axis specification (GO:0070986)6.22871788
5microtubule bundle formation (GO:0001578)5.90278840
6intraciliary transport (GO:0042073)5.89726457
7cilium organization (GO:0044782)5.52557736
8cilium assembly (GO:0042384)5.30486178
9response to xenobiotic stimulus (GO:0009410)5.26261622
10ventricular system development (GO:0021591)5.20047165
11regulation of microtubule-based movement (GO:0060632)5.17063721
12primary alcohol catabolic process (GO:0034310)4.50410063
13protein localization to cilium (GO:0061512)4.49051748
14cilium morphogenesis (GO:0060271)4.31630966
15vitamin transmembrane transport (GO:0035461)4.23335947
16cellular component assembly involved in morphogenesis (GO:0010927)4.22835525
17oligosaccharide biosynthetic process (GO:0009312)4.17725627
18negative regulation of T cell differentiation in thymus (GO:0033085)4.07548486
19nucleoside diphosphate phosphorylation (GO:0006165)4.01274993
20pyrimidine-containing compound transmembrane transport (GO:0072531)3.88908752
21ethanol metabolic process (GO:0006067)3.88737814
22microtubule-based movement (GO:0007018)3.87547955
23aldehyde catabolic process (GO:0046185)3.83349519
24centriole assembly (GO:0098534)3.79374663
25cell projection assembly (GO:0030031)3.69315876
26lateral ventricle development (GO:0021670)3.57693288
27protein polyglutamylation (GO:0018095)3.56591023
28diterpenoid biosynthetic process (GO:0016102)3.47984786
29one-carbon compound transport (GO:0019755)3.44893776
30exogenous drug catabolic process (GO:0042738)3.42749989
31regulation of interleukin-5 production (GO:0032674)3.38173553
32regulation of germinal center formation (GO:0002634)3.36379555
33rRNA catabolic process (GO:0016075)3.28318912
34negative regulation of humoral immune response (GO:0002921)3.26027541
35retinal rod cell development (GO:0046548)3.25979269
36regulation of interleukin-13 production (GO:0032656)3.25621826
37negative regulation of B cell mediated immunity (GO:0002713)3.19319024
38negative regulation of immunoglobulin mediated immune response (GO:0002890)3.19319024
39tolerance induction (GO:0002507)3.17332581
40photoreceptor cell maintenance (GO:0045494)3.16657497
41nucleobase catabolic process (GO:0046113)3.13755507
42cornea development in camera-type eye (GO:0061303)3.12774196
43terpenoid biosynthetic process (GO:0016114)3.12205627
44lung epithelium development (GO:0060428)3.11251202
45epithelial cell differentiation involved in kidney development (GO:0035850)3.06182106
46glutathione derivative metabolic process (GO:1901685)3.03949272
47glutathione derivative biosynthetic process (GO:1901687)3.03949272
48determination of left/right symmetry (GO:0007368)3.00983673
49retinoic acid metabolic process (GO:0042573)2.98371689
50nonmotile primary cilium assembly (GO:0035058)2.97508207
51sperm motility (GO:0030317)2.95139644
52cytoplasmic microtubule organization (GO:0031122)2.88039966
53determination of bilateral symmetry (GO:0009855)2.81816547
54ethanol oxidation (GO:0006069)2.81766721
55drug catabolic process (GO:0042737)2.80121660
56GTP biosynthetic process (GO:0006183)2.76745385
57smoothened signaling pathway (GO:0007224)2.73590135
58retinal cone cell development (GO:0046549)2.73119986
59microtubule severing (GO:0051013)2.72249259
60specification of symmetry (GO:0009799)2.72043061
61neural tube formation (GO:0001841)2.69449615
62regulation of autophagic vacuole assembly (GO:2000785)2.60039646
63centriole replication (GO:0007099)2.57114051
64microtubule depolymerization (GO:0007019)2.54833856
65positive regulation of catecholamine secretion (GO:0033605)2.51668728
66behavioral response to nicotine (GO:0035095)2.49030895
67benzene-containing compound metabolic process (GO:0042537)2.43704335
68positive regulation of tolerance induction (GO:0002645)2.42949836
69O-glycan processing (GO:0016266)2.42418336
70ubiquinone biosynthetic process (GO:0006744)2.40776825
71positive regulation of amino acid transport (GO:0051957)2.39634382
72negative regulation of amino acid transport (GO:0051956)2.39047601
73GPI anchor metabolic process (GO:0006505)2.36858092
74multicellular organism reproduction (GO:0032504)2.33837486
75establishment of planar polarity (GO:0001736)2.32454634
76establishment of tissue polarity (GO:0007164)2.32454634
77establishment or maintenance of monopolar cell polarity (GO:0061339)2.31607352
78establishment of monopolar cell polarity (GO:0061162)2.31607352
79microtubule polymerization or depolymerization (GO:0031109)2.31512544
80photoreceptor cell differentiation (GO:0046530)2.30952373
81eye photoreceptor cell differentiation (GO:0001754)2.30952373
82regulation of collateral sprouting (GO:0048670)2.30488186
83response to pheromone (GO:0019236)2.29754349
84pyrimidine nucleobase catabolic process (GO:0006208)2.28861886
85negative regulation of inclusion body assembly (GO:0090084)2.28385914
86nucleotide phosphorylation (GO:0046939)2.27667340
87sperm capacitation (GO:0048240)2.26437123
88preassembly of GPI anchor in ER membrane (GO:0016254)2.26224939
89microtubule-based process (GO:0007017)2.26141622
90GPI anchor biosynthetic process (GO:0006506)2.26052052
91carnitine metabolic process (GO:0009437)2.25595822
92calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.25128069
93primary alcohol metabolic process (GO:0034308)2.22803209
94ubiquinone metabolic process (GO:0006743)2.22231453
95axonemal dynein complex assembly (GO:0070286)16.6231355
96cilium or flagellum-dependent cell motility (GO:0001539)14.5167879
97cilium movement (GO:0003341)12.9082015
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.6464702
99motile cilium assembly (GO:0044458)11.5181431
100epithelial cilium movement (GO:0003351)11.1274846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.21195848
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.87574242
3ZNF274_21170338_ChIP-Seq_K562_Hela2.76911944
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48701802
5EZH2_22144423_ChIP-Seq_EOC_Human2.06251573
6DROSHA_22980978_ChIP-Seq_HELA_Human2.04524934
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.96235830
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82902554
9* FUS_26573619_Chip-Seq_HEK293_Human1.81982173
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78717162
11POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77860900
12CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74370608
13PIAS1_25552417_ChIP-Seq_VCAP_Human1.74235982
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67877832
15IGF1R_20145208_ChIP-Seq_DFB_Human1.67043347
16NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61530162
17EWS_26573619_Chip-Seq_HEK293_Human1.61438336
18TAF15_26573619_Chip-Seq_HEK293_Human1.58495456
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55428709
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.55016855
21TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54348136
22* ETV1_20927104_ChIP-Seq_GIST48_Human1.53820988
23ER_23166858_ChIP-Seq_MCF-7_Human1.53624849
24FOXA1_25329375_ChIP-Seq_VCAP_Human1.47938530
25FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47938530
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45948669
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45854422
28* PHF8_20622853_ChIP-Seq_HELA_Human1.43221881
29SMAD4_21799915_ChIP-Seq_A2780_Human1.42340759
30PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.42080735
31* RBPJ_21746931_ChIP-Seq_IB4_Human1.41040051
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40404364
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39226077
34AR_20517297_ChIP-Seq_VCAP_Human1.38831169
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37838268
36CBP_20019798_ChIP-Seq_JUKART_Human1.37838268
37TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.37289901
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34598435
39P300_19829295_ChIP-Seq_ESCs_Human1.34423545
40KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32214740
41BCAT_22108803_ChIP-Seq_LS180_Human1.29030818
42FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28999168
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28734366
44* GATA6_21074721_ChIP-Seq_CACO-2_Human1.27283985
45TCF4_22108803_ChIP-Seq_LS180_Human1.26967669
46SOX2_19829295_ChIP-Seq_ESCs_Human1.26306395
47NANOG_19829295_ChIP-Seq_ESCs_Human1.26306395
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25387759
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25003496
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24724163
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23141349
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22844779
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21992551
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21654963
55STAT1_20625510_ChIP-Seq_HELA_Human1.21554113
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21185325
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21114956
58TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21086168
59CBX2_22325352_ChIP-Seq_293T-Rex_Human1.20266058
60* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20193469
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.19907259
62RUNX2_22187159_ChIP-Seq_PCA_Human1.19329113
63NCOR_22424771_ChIP-Seq_293T_Human1.18835035
64NFYA_21822215_ChIP-Seq_K562_Human1.18538722
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18318172
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18062045
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.17785638
68* HNFA_21074721_ChIP-Seq_CACO-2_Human1.17276917
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14229979
70* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13830573
71STAT3_23295773_ChIP-Seq_U87_Human1.13718506
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.13483081
73REST_21632747_ChIP-Seq_MESCs_Mouse1.12846939
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.11797271
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.11599747
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11231713
77GBX2_23144817_ChIP-Seq_PC3_Human1.11057101
78SMRT_27268052_Chip-Seq_Bcells_Human1.10903387
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10208658
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09012028
81AR_21572438_ChIP-Seq_LNCaP_Human1.08916763
82AR_25329375_ChIP-Seq_VCAP_Human1.08763035
83TCF4_23295773_ChIP-Seq_U87_Human1.08056841
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07704335
85* NFYB_21822215_ChIP-Seq_K562_Human1.07005198
86TBL1_22424771_ChIP-Seq_293T_Human1.06550734
87TP53_18474530_ChIP-ChIP_U2OS_Human1.06110218
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.05249483
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05096224
90TP63_23658742_ChIP-Seq_EP156T_Human1.03663999
91MYC_19829295_ChIP-Seq_ESCs_Human1.03062376
92NANOG_20526341_ChIP-Seq_ESCs_Human1.02945808
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02604595
94AHR_22903824_ChIP-Seq_MCF-7_Human1.01401245
95TP53_22573176_ChIP-Seq_HFKS_Human1.00932806
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99616609
97CEBPB_22108803_ChIP-Seq_LS180_Human0.99508395
98TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99113231
99TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.98184635
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98179829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.35292093
2MP0002653_abnormal_ependyma_morphology4.94585244
3MP0001984_abnormal_olfaction3.53260297
4MP0002132_abnormal_respiratory_system3.21962716
5MP0004043_abnormal_pH_regulation3.01283962
6MP0002277_abnormal_respiratory_mucosa2.84023415
7MP0004133_heterotaxia2.47108687
8MP0008789_abnormal_olfactory_epithelium2.26160257
9MP0009780_abnormal_chondrocyte_physiolo1.88809898
10MP0003880_abnormal_central_pattern1.82708932
11MP0001881_abnormal_mammary_gland1.82139343
12MP0002160_abnormal_reproductive_system1.77352537
13MP0005551_abnormal_eye_electrophysiolog1.73750768
14MP0001485_abnormal_pinna_reflex1.72911683
15MP0009046_muscle_twitch1.72034368
16MP0000465_gastrointestinal_hemorrhage1.70896510
17MP0005636_abnormal_mineral_homeostasis1.70693984
18MP0005377_hearing/vestibular/ear_phenot1.67547246
19MP0003878_abnormal_ear_physiology1.67547246
20MP0005645_abnormal_hypothalamus_physiol1.66123686
21MP0005083_abnormal_biliary_tract1.64009324
22MP0003195_calcinosis1.62705355
23MP0001765_abnormal_ion_homeostasis1.61991056
24MP0008995_early_reproductive_senescence1.55659607
25MP0002735_abnormal_chemical_nociception1.55564587
26MP0004782_abnormal_surfactant_physiolog1.50870016
27MP0000383_abnormal_hair_follicle1.49617699
28MP0006276_abnormal_autonomic_nervous1.48443579
29MP0005253_abnormal_eye_physiology1.48236220
30MP0002102_abnormal_ear_morphology1.47649129
31MP0005394_taste/olfaction_phenotype1.39951057
32MP0005499_abnormal_olfactory_system1.39951057
33MP0002282_abnormal_trachea_morphology1.39621573
34MP0002822_catalepsy1.38288604
35MP0002234_abnormal_pharynx_morphology1.38016310
36MP0004019_abnormal_vitamin_homeostasis1.36428407
37MP0002876_abnormal_thyroid_physiology1.35290073
38MP0005646_abnormal_pituitary_gland1.35052551
39MP0003718_maternal_effect1.34814179
40MP0002638_abnormal_pupillary_reflex1.33672580
41MP0008872_abnormal_physiological_respon1.32712888
42MP0004142_abnormal_muscle_tone1.28768629
43MP0001968_abnormal_touch/_nociception1.27627215
44MP0002734_abnormal_mechanical_nocicepti1.27612301
45MP0005389_reproductive_system_phenotype1.24644575
46MP0009745_abnormal_behavioral_response1.22597749
47MP0001970_abnormal_pain_threshold1.22355253
48MP0005084_abnormal_gallbladder_morpholo1.20844477
49MP0010386_abnormal_urinary_bladder1.20282618
50MP0003656_abnormal_erythrocyte_physiolo1.19003538
51MP0002272_abnormal_nervous_system1.13796824
52MP0001324_abnormal_eye_pigmentation1.11862529
53MP0003806_abnormal_nucleotide_metabolis1.11055075
54MP0001664_abnormal_digestion1.10871549
55MP0001486_abnormal_startle_reflex1.09070816
56MP0001986_abnormal_taste_sensitivity1.07921410
57MP0004885_abnormal_endolymph1.07523410
58MP0002909_abnormal_adrenal_gland1.05173941
59MP0003011_delayed_dark_adaptation1.02920191
60MP0002557_abnormal_social/conspecific_i0.98964126
61MP0009643_abnormal_urine_homeostasis0.97840083
62MP0002572_abnormal_emotion/affect_behav0.97620167
63MP0008877_abnormal_DNA_methylation0.97141701
64MP0002736_abnormal_nociception_after0.96537041
65MP0005075_abnormal_melanosome_morpholog0.94816671
66MP0000613_abnormal_salivary_gland0.93985382
67MP0008961_abnormal_basal_metabolism0.93052993
68MP0000678_abnormal_parathyroid_gland0.92093918
69MP0000631_abnormal_neuroendocrine_gland0.91351080
70MP0006072_abnormal_retinal_apoptosis0.91140136
71MP0005085_abnormal_gallbladder_physiolo0.91039185
72MP0000372_irregular_coat_pigmentation0.91014128
73MP0005623_abnormal_meninges_morphology0.90502661
74MP0002733_abnormal_thermal_nociception0.90184052
75MP0005395_other_phenotype0.89268044
76MP0001188_hyperpigmentation0.88796207
77MP0001905_abnormal_dopamine_level0.88535231
78MP0003186_abnormal_redox_activity0.87872881
79MP0001963_abnormal_hearing_physiology0.87782079
80MP0005195_abnormal_posterior_eye0.87269314
81MP0002229_neurodegeneration0.86664305
82MP0004147_increased_porphyrin_level0.85439795
83MP0000049_abnormal_middle_ear0.85339192
84MP0001835_abnormal_antigen_presentation0.84583418
85MP0000681_abnormal_thyroid_gland0.82939492
86MP0003698_abnormal_male_reproductive0.82642901
87MP0005408_hypopigmentation0.82294422
88MP0002136_abnormal_kidney_physiology0.80885552
89MP0003633_abnormal_nervous_system0.78144421
90MP0001929_abnormal_gametogenesis0.77314890
91MP0004484_altered_response_of0.74943744
92MP0002168_other_aberrant_phenotype0.74795040
93MP0001502_abnormal_circadian_rhythm0.73813947
94MP0005365_abnormal_bile_salt0.71173534
95MP0004215_abnormal_myocardial_fiber0.68652419
96MP0000026_abnormal_inner_ear0.68376718
97MP0002067_abnormal_sensory_capabilities0.68136202
98MP0010678_abnormal_skin_adnexa0.68064879
99MP0004145_abnormal_muscle_electrophysio0.66706004
100MP0002148_abnormal_hypersensitivity_rea0.66439014

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.78170203
2Abnormal respiratory motile cilium physiology (HP:0012261)9.76313832
3Rhinitis (HP:0012384)8.56191095
4Chronic bronchitis (HP:0004469)6.73733821
5Bronchiectasis (HP:0002110)6.32481277
6Nasal polyposis (HP:0100582)5.15467421
7Abnormality of the nasal mucosa (HP:0000433)4.21359128
8Pancreatic fibrosis (HP:0100732)4.12683624
9True hermaphroditism (HP:0010459)3.98748326
10Recurrent sinusitis (HP:0011108)3.93660277
11Molar tooth sign on MRI (HP:0002419)3.90232344
12Abnormality of midbrain morphology (HP:0002418)3.90232344
13Bronchitis (HP:0012387)3.85804947
14Chronic sinusitis (HP:0011109)3.70111134
15Pancreatic cysts (HP:0001737)3.62931740
16Infertility (HP:0000789)3.61530958
17Occipital encephalocele (HP:0002085)3.40075571
18Nephronophthisis (HP:0000090)3.35393795
19Medial flaring of the eyebrow (HP:0010747)3.09472148
20Recurrent otitis media (HP:0000403)3.01247311
21Chronic otitis media (HP:0000389)2.98950102
22Cystic liver disease (HP:0006706)2.96763751
23Chronic hepatic failure (HP:0100626)2.93476707
24Tubulointerstitial nephritis (HP:0001970)2.83823289
25Male infertility (HP:0003251)2.70712744
26Abnormality of the renal medulla (HP:0100957)2.70025300
27Gait imbalance (HP:0002141)2.65139216
28Congenital primary aphakia (HP:0007707)2.62712137
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.56236545
30Hyperactive renin-angiotensin system (HP:0000841)2.54630028
31Postaxial foot polydactyly (HP:0001830)2.53048581
32Congenital hepatic fibrosis (HP:0002612)2.39252587
33Nephrogenic diabetes insipidus (HP:0009806)2.37605746
34Anencephaly (HP:0002323)2.26839198
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.25437313
36Asplenia (HP:0001746)2.23429435
37Decreased circulating renin level (HP:0003351)2.12831865
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.12054869
39Tubular atrophy (HP:0000092)2.10286404
40Male pseudohermaphroditism (HP:0000037)2.07952181
41Decreased central vision (HP:0007663)2.07094002
42Abnormal rod and cone electroretinograms (HP:0008323)2.04232203
43Sclerocornea (HP:0000647)2.03946211
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.8010181
45Dynein arm defect of respiratory motile cilia (HP:0012255)10.1675281
46Absent/shortened dynein arms (HP:0200106)10.1675281
47Abnormal respiratory epithelium morphology (HP:0012253)10.0808632
48Abnormal respiratory motile cilium morphology (HP:0005938)10.0808632
49Postaxial hand polydactyly (HP:0001162)1.91274501
50Vaginal atresia (HP:0000148)1.88413345
51Renal salt wasting (HP:0000127)1.88335441
52Recurrent bronchitis (HP:0002837)1.87853846
53Genital tract atresia (HP:0001827)1.87589582
54Oculomotor apraxia (HP:0000657)1.82314523
55Abnormality of macular pigmentation (HP:0008002)1.81398034
56Furrowed tongue (HP:0000221)1.80521335
57Poor coordination (HP:0002370)1.76815138
58Atelectasis (HP:0100750)1.75591104
59Tubulointerstitial abnormality (HP:0001969)1.68888630
60Abnormal drinking behavior (HP:0030082)1.67711615
61Polydipsia (HP:0001959)1.67711615
62Supernumerary spleens (HP:0009799)1.64582467
63Abnormality of the renal cortex (HP:0011035)1.62242268
64Nephropathy (HP:0000112)1.60431519
65Abolished electroretinogram (ERG) (HP:0000550)1.57190644
66Median cleft lip (HP:0000161)1.53245596
67Congenital stationary night blindness (HP:0007642)1.50630954
68Hypokalemic alkalosis (HP:0001949)1.49902069
69Abnormality of renin-angiotensin system (HP:0000847)1.48721974
70Retinitis pigmentosa (HP:0000510)1.46408761
71Hyperaldosteronism (HP:0000859)1.44558387
72Fetal akinesia sequence (HP:0001989)1.43817928
73Bile duct proliferation (HP:0001408)1.42864462
74Abnormal biliary tract physiology (HP:0012439)1.42864462
75Cone-rod dystrophy (HP:0000548)1.42170399
76Preaxial hand polydactyly (HP:0001177)1.40743270
77Narrow forehead (HP:0000341)1.37473041
78Tubulointerstitial fibrosis (HP:0005576)1.34433536
79Absent speech (HP:0001344)1.31480120
80Dyschromatopsia (HP:0007641)1.30029322
81Abnormality of renal excretion (HP:0011036)1.28171453
82Macular degeneration (HP:0000608)1.28070177
83Hyperkalemia (HP:0002153)1.27033354
84Polyuria (HP:0000103)1.26353991
85Type II lissencephaly (HP:0007260)1.23266959
86Hip dysplasia (HP:0001385)1.23264604
87Multicystic kidney dysplasia (HP:0000003)1.22878584
88Alveolar cell carcinoma (HP:0006519)1.22443697
89Specific learning disability (HP:0001328)1.20643231
90Aplasia/Hypoplasia of the lens (HP:0008063)1.20304458
91Type 2 muscle fiber atrophy (HP:0003554)1.20084519
92Left ventricular hypertrophy (HP:0001712)1.18000867
93Aganglionic megacolon (HP:0002251)1.17830989
94Absent frontal sinuses (HP:0002688)1.17387821
95Prominent nasal bridge (HP:0000426)1.16940532
96Stage 5 chronic kidney disease (HP:0003774)1.16006386
97Agitation (HP:0000713)1.15511187
98Broad-based gait (HP:0002136)1.14381135
99Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.14220524
100Broad foot (HP:0001769)1.11510999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.08676243
2BCKDK4.96114944
3MAP4K23.93994522
4MST43.84321987
5EIF2AK32.48080117
6TAOK32.18396733
7PINK12.08970570
8EPHA32.01462561
9WNK41.98470245
10BCR1.98107208
11NUAK11.97399681
12MAPKAPK31.92608736
13ADRBK21.77001233
14EPHA21.68699320
15DYRK21.63108471
16GRK11.60883329
17MAP3K41.49760146
18MAPK131.48228880
19FRK1.46956686
20PNCK1.45465573
21STK391.39312342
22BMPR1B1.39269859
23MAP2K71.31541176
24TXK1.26319854
25CASK1.19371735
26TLK11.19221048
27TRIM281.18979011
28NME11.16235004
29CDK191.16129290
30ERBB31.11778572
31OXSR11.06443926
32WNK31.00221677
33MAPKAPK50.93587520
34CAMKK20.91668694
35TSSK60.83453542
36PRKCQ0.82677585
37CCNB10.79770201
38CSNK1G20.77448076
39MARK10.76690335
40PTK2B0.72000920
41CAMKK10.69281752
42MINK10.67778960
43PRKCE0.67046349
44PAK30.61442935
45PRKCG0.61203782
46ADRBK10.59955431
47CSNK1G30.59620950
48TIE10.56684217
49EIF2AK10.55564113
50KIT0.54949059
51PRKCD0.54716645
52ABL10.53655191
53INSRR0.52968232
54MUSK0.52027970
55HIPK20.51808388
56DAPK10.50857181
57VRK20.50193452
58PRKCI0.49992243
59PRKACA0.47187828
60CSNK1A1L0.46214968
61DAPK20.45197777
62STK100.43848982
63MST1R0.43647529
64ZAK0.43335389
65OBSCN0.43052285
66TEC0.43046532
67BRSK20.41406209
68PRKCA0.41261265
69LRRK20.40995912
70TRPM70.40991952
71RPS6KA40.40790700
72TESK10.40123992
73GRK50.39950598
74RPS6KA50.39281767
75CAMK2A0.39030917
76MATK0.38912462
77MAP3K120.38437368
78IGF1R0.38253697
79ERBB20.37268402
80CSNK1G10.35688135
81CSNK1A10.34950745
82MKNK20.34668301
83VRK10.32852058
84STK110.32628657
85PIM20.32007019
86PRKCZ0.31593765
87STK240.30483966
88DYRK1B0.30117022
89TNIK0.29833193
90CAMK2G0.29706892
91LIMK10.29664282
92STK380.27777301
93SGK10.26958051
94CHUK0.26760838
95PRKAA20.26171222
96STK38L0.25244140
97IRAK10.25184914
98DYRK1A0.25030426
99PRKG10.24229807
100TBK10.24071094

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.80310399
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.10654005
3Asthma_Homo sapiens_hsa053102.85954908
4Chemical carcinogenesis_Homo sapiens_hsa052042.76730014
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.62164352
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.31028204
7Huntingtons disease_Homo sapiens_hsa050162.30341269
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30147500
9Linoleic acid metabolism_Homo sapiens_hsa005912.27406320
10Histidine metabolism_Homo sapiens_hsa003402.22275103
11Allograft rejection_Homo sapiens_hsa053302.17373813
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.09249563
13Autoimmune thyroid disease_Homo sapiens_hsa053202.03791130
14Type I diabetes mellitus_Homo sapiens_hsa049401.92721611
15* Starch and sucrose metabolism_Homo sapiens_hsa005001.87300202
16* Carbohydrate digestion and absorption_Homo sapiens_hsa049731.83197007
17beta-Alanine metabolism_Homo sapiens_hsa004101.82304376
18Propanoate metabolism_Homo sapiens_hsa006401.76804549
19Graft-versus-host disease_Homo sapiens_hsa053321.72914521
20* Salivary secretion_Homo sapiens_hsa049701.69140555
21Peroxisome_Homo sapiens_hsa041461.65425002
22Phenylalanine metabolism_Homo sapiens_hsa003601.63629761
23Tyrosine metabolism_Homo sapiens_hsa003501.56159366
24Retinol metabolism_Homo sapiens_hsa008301.42063624
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39729459
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39297870
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.33884953
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30295122
29Butanoate metabolism_Homo sapiens_hsa006501.29474006
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26565435
31Phototransduction_Homo sapiens_hsa047441.26541437
32Fatty acid biosynthesis_Homo sapiens_hsa000611.24046478
33Oxidative phosphorylation_Homo sapiens_hsa001901.23056174
34Olfactory transduction_Homo sapiens_hsa047401.22970947
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22294231
36Glutathione metabolism_Homo sapiens_hsa004801.20231045
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16924369
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16056659
39Nicotine addiction_Homo sapiens_hsa050331.15556191
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02289256
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99987468
42Antigen processing and presentation_Homo sapiens_hsa046120.99836586
43Nitrogen metabolism_Homo sapiens_hsa009100.97839216
44Steroid biosynthesis_Homo sapiens_hsa001000.97217036
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97187521
46Rheumatoid arthritis_Homo sapiens_hsa053230.95271524
47Protein export_Homo sapiens_hsa030600.94502836
48Arachidonic acid metabolism_Homo sapiens_hsa005900.92522396
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92354658
50Ether lipid metabolism_Homo sapiens_hsa005650.91434286
51ABC transporters_Homo sapiens_hsa020100.89849033
52Taste transduction_Homo sapiens_hsa047420.89393865
53Parkinsons disease_Homo sapiens_hsa050120.86901045
54Staphylococcus aureus infection_Homo sapiens_hsa051500.86393023
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86316028
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85924533
57Sulfur relay system_Homo sapiens_hsa041220.82815735
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82775104
59Sphingolipid metabolism_Homo sapiens_hsa006000.81458098
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.81194968
61Tryptophan metabolism_Homo sapiens_hsa003800.80171789
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.79713377
63Cardiac muscle contraction_Homo sapiens_hsa042600.72732116
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69027308
65Hematopoietic cell lineage_Homo sapiens_hsa046400.68537083
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66881690
67Fatty acid degradation_Homo sapiens_hsa000710.64827084
68* Metabolic pathways_Homo sapiens_hsa011000.64422251
69Serotonergic synapse_Homo sapiens_hsa047260.62041958
70Viral myocarditis_Homo sapiens_hsa054160.61284438
71RNA polymerase_Homo sapiens_hsa030200.59772962
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55878309
73Ovarian steroidogenesis_Homo sapiens_hsa049130.53324581
74Alzheimers disease_Homo sapiens_hsa050100.52716802
75Collecting duct acid secretion_Homo sapiens_hsa049660.52397088
76Circadian rhythm_Homo sapiens_hsa047100.51381701
77Purine metabolism_Homo sapiens_hsa002300.50390044
78Phagosome_Homo sapiens_hsa041450.44458862
79Selenocompound metabolism_Homo sapiens_hsa004500.40584372
80Morphine addiction_Homo sapiens_hsa050320.39600395
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.38626918
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38289470
83Glycerolipid metabolism_Homo sapiens_hsa005610.37448123
84Tight junction_Homo sapiens_hsa045300.37252915
85Mineral absorption_Homo sapiens_hsa049780.36463755
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34264081
87Circadian entrainment_Homo sapiens_hsa047130.34045048
88Regulation of autophagy_Homo sapiens_hsa041400.33262810
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32786045
90Arginine and proline metabolism_Homo sapiens_hsa003300.31716680
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31602781
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31579955
93Primary immunodeficiency_Homo sapiens_hsa053400.30450462
94Pancreatic secretion_Homo sapiens_hsa049720.29356697
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.28562210
96Proteasome_Homo sapiens_hsa030500.28114960
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27632275
98Basal transcription factors_Homo sapiens_hsa030220.24726591
99RNA degradation_Homo sapiens_hsa030180.24570134
100GABAergic synapse_Homo sapiens_hsa047270.23613365

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