AMY1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)7.74346997
2negative regulation of humoral immune response (GO:0002921)7.21499794
3left/right pattern formation (GO:0060972)7.13247341
4regulation of cilium movement (GO:0003352)5.94279080
5primary alcohol catabolic process (GO:0034310)5.87072205
6one-carbon compound transport (GO:0019755)5.69274711
7negative regulation of B cell mediated immunity (GO:0002713)5.69121387
8negative regulation of immunoglobulin mediated immune response (GO:0002890)5.69121387
9left/right axis specification (GO:0070986)5.39292610
10iron ion import (GO:0097286)5.36113333
11ethanol metabolic process (GO:0006067)5.30463321
12negative regulation of complement activation (GO:0045916)5.22437033
13vitamin transmembrane transport (GO:0035461)5.03293744
14ventricular system development (GO:0021591)4.85520805
15response to xenobiotic stimulus (GO:0009410)4.84119264
16microtubule bundle formation (GO:0001578)4.71234915
17negative regulation of protein activation cascade (GO:2000258)4.63536134
18intraciliary transport (GO:0042073)4.54515049
19regulation of interleukin-5 production (GO:0032674)4.31129647
20pyrimidine-containing compound transmembrane transport (GO:0072531)4.31124064
21cilium organization (GO:0044782)4.24585014
22regulation of interleukin-13 production (GO:0032656)4.21434000
23diterpenoid biosynthetic process (GO:0016102)4.20337677
24cilium assembly (GO:0042384)4.12605350
25tolerance induction (GO:0002507)4.11274737
26ethanol oxidation (GO:0006069)4.10381134
27establishment of apical/basal cell polarity (GO:0035089)4.05833112
28lung epithelium development (GO:0060428)3.95325172
29glomerular epithelial cell development (GO:0072310)3.80045553
30import into cell (GO:0098657)3.76662866
31oligosaccharide biosynthetic process (GO:0009312)3.73932682
32positive regulation of tolerance induction (GO:0002645)3.69789154
33regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.66180065
34regulation of complement activation (GO:0030449)3.66137207
35regulation of germinal center formation (GO:0002634)3.63081369
36negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.59895638
37dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.59703863
38centriole assembly (GO:0098534)3.57040909
39trivalent inorganic anion homeostasis (GO:0072506)3.56251763
40phosphate ion homeostasis (GO:0055062)3.56251763
41regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.54203342
42establishment of tissue polarity (GO:0007164)3.53857168
43establishment of planar polarity (GO:0001736)3.53857168
44O-glycan processing (GO:0016266)3.51571916
45phosphate ion transmembrane transport (GO:0035435)3.51497437
46negative regulation of T cell differentiation in thymus (GO:0033085)3.44353878
47regulation of apoptotic cell clearance (GO:2000425)3.42447215
48establishment of monopolar cell polarity (GO:0061162)3.39913361
49establishment or maintenance of monopolar cell polarity (GO:0061339)3.39913361
50regulation of protein activation cascade (GO:2000257)3.37023317
51regulation of microtubule-based movement (GO:0060632)3.36921053
52calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.36348937
53protein localization to cilium (GO:0061512)3.34677666
54multicellular organismal water homeostasis (GO:0050891)3.31486133
55microtubule-based movement (GO:0007018)3.31128983
56cellular response to nitric oxide (GO:0071732)3.30400040
57cellular component assembly involved in morphogenesis (GO:0010927)3.28220059
58sperm capacitation (GO:0048240)3.25225672
59macrophage chemotaxis (GO:0048246)3.24218038
60cell projection assembly (GO:0030031)3.08479698
61cellular anion homeostasis (GO:0030002)3.02412851
62polyol transport (GO:0015791)3.01394974
63membrane protein proteolysis (GO:0033619)3.00611333
64exogenous drug catabolic process (GO:0042738)2.98884290
65regulation of tolerance induction (GO:0002643)2.96692117
66copper ion transport (GO:0006825)2.95069342
67negative regulation of inclusion body assembly (GO:0090084)2.94811902
68positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.94694119
69regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.92067440
70peptide catabolic process (GO:0043171)2.91256750
71cilium morphogenesis (GO:0060271)2.90095278
72cellular response to reactive nitrogen species (GO:1902170)2.90010046
73sodium ion homeostasis (GO:0055078)2.89375184
74phosphate ion transport (GO:0006817)2.89310506
75retinoic acid metabolic process (GO:0042573)2.85814168
76excretion (GO:0007588)2.82661753
77regulation of humoral immune response (GO:0002920)2.82431758
78terpenoid biosynthetic process (GO:0016114)2.80743471
79nucleoside diphosphate phosphorylation (GO:0006165)2.80194052
80hypotonic response (GO:0006971)2.79460013
81water homeostasis (GO:0030104)2.79287613
82primary alcohol metabolic process (GO:0034308)2.79270383
83regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.75144967
84lipoxygenase pathway (GO:0019372)2.74286008
85lateral ventricle development (GO:0021670)2.66441392
86cytoplasmic microtubule organization (GO:0031122)2.64228245
87thyroid hormone generation (GO:0006590)2.63486410
88negative regulation of T cell proliferation (GO:0042130)2.60428871
89renal absorption (GO:0070293)2.60262177
90amyloid precursor protein catabolic process (GO:0042987)2.57302380
91negative regulation of interleukin-2 production (GO:0032703)2.57088663
92glutathione derivative metabolic process (GO:1901685)2.57050115
93axonemal dynein complex assembly (GO:0070286)16.8964144
94surfactant homeostasis (GO:0043129)14.3567528
95cilium or flagellum-dependent cell motility (GO:0001539)14.2189130
96cilium movement (GO:0003341)12.0458012
97chemical homeostasis within a tissue (GO:0048875)11.5400284
98motile cilium assembly (GO:0044458)11.3387127
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.9520215
100epithelial cilium movement (GO:0003351)10.0371868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.95026478
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.42913691
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.41544753
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.30747225
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.70767622
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.52941187
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44163539
8STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.33841373
9SOX2_27498859_Chip-Seq_STOMACH_Mouse2.18271461
10DROSHA_22980978_ChIP-Seq_HELA_Human2.17958815
11FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.10371540
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.08927259
13SOX2_20726797_ChIP-Seq_SW620_Human1.96781406
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.89723877
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84640933
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80369979
17AHR_22903824_ChIP-Seq_MCF-7_Human1.80229463
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78598223
19AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.76688681
20FOXM1_26456572_ChIP-Seq_MCF-7_Human1.75691669
21RUNX1_27514584_Chip-Seq_MCF-7_Human1.73982973
22ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.69480615
23KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.68083157
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.63957105
25TP63_23658742_ChIP-Seq_EP156T_Human1.63429937
26FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.62391457
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59698259
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59498596
29CLOCK_20551151_ChIP-Seq_293T_Human1.59390032
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59094411
31SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56830217
32* ETV1_20927104_ChIP-Seq_GIST48_Human1.56488683
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54888543
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51885050
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.51810940
36GATA4_25053715_ChIP-Seq_YYC3_Human1.51009833
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.49897177
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.49877964
39KLF5_25053715_ChIP-Seq_YYC3_Human1.46252301
40P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44164749
41AR_21572438_ChIP-Seq_LNCaP_Human1.41959080
42* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.40942364
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40540661
44FOXA1_25552417_ChIP-Seq_VCAP_Human1.38992728
45SMC4_20622854_ChIP-Seq_HELA_Human1.37864352
46* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.37760367
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35589292
48STAT1_20625510_ChIP-Seq_HELA_Human1.35381471
49* PHF8_20622853_ChIP-Seq_HELA_Human1.34415920
50* RBPJ_21746931_ChIP-Seq_IB4_Human1.33529007
51TP53_18474530_ChIP-ChIP_U2OS_Human1.33157027
52* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.31846628
53CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31587827
54* HNFA_21074721_ChIP-Seq_CACO-2_Human1.28904307
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28534085
56* GATA6_21074721_ChIP-Seq_CACO-2_Human1.27791448
57GATA3_24758297_ChIP-Seq_MCF-7_Human1.27621149
58PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26852421
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.26448502
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.19140660
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.18819745
62NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18072193
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16994744
64SMAD3_21741376_ChIP-Seq_HESCs_Human1.16625185
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15226086
66* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13999318
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.12703098
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.12703098
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12488145
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11108653
71RACK7_27058665_Chip-Seq_MCF-7_Human1.11101210
72RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10294206
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09814384
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08423227
75TP63_22573176_ChIP-Seq_HFKS_Human1.07789833
76RXR_22158963_ChIP-Seq_LIVER_Mouse1.06860239
77CREB1_26743006_Chip-Seq_LNCaP_Human1.03685285
78FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03595873
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02692022
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02640202
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.01968376
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.01492004
83GATA2_21666600_ChIP-Seq_HMVEC_Human0.99728667
84GATA1_19941826_ChIP-Seq_K562_Human0.99108516
85* NFYA_21822215_ChIP-Seq_K562_Human0.98218224
86EP300_21415370_ChIP-Seq_HL-1_Mouse0.98197935
87CJUN_26792858_Chip-Seq_BT549_Human0.95968924
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94906347
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92939922
90* NFYB_21822215_ChIP-Seq_K562_Human0.92671344
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92376467
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90572584
93SMRT_27268052_Chip-Seq_Bcells_Human0.90156838
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89236475
95GATA6_25053715_ChIP-Seq_YYC3_Human0.88357121
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.87701479
97* TBL1_22424771_ChIP-Seq_293T_Human0.84125327
98IRF8_27001747_Chip-Seq_BMDM_Mouse0.81786808
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81783841
100GATA2_19941826_ChIP-Seq_K562_Human0.79321758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog5.53884526
2MP0008875_abnormal_xenobiotic_pharmacok5.04079127
3MP0001958_emphysema4.88207849
4MP0002132_abnormal_respiratory_system4.24649429
5MP0005083_abnormal_biliary_tract3.91893270
6MP0008004_abnormal_stomach_pH3.83614349
7MP0002653_abnormal_ependyma_morphology3.55397718
8MP0008995_early_reproductive_senescence3.51599744
9MP0004043_abnormal_pH_regulation3.44170477
10MP0009780_abnormal_chondrocyte_physiolo2.71505994
11MP0002277_abnormal_respiratory_mucosa2.69853096
12MP0001984_abnormal_olfaction2.35442945
13MP0008789_abnormal_olfactory_epithelium2.29563709
14MP0000383_abnormal_hair_follicle2.19036627
15MP0004019_abnormal_vitamin_homeostasis2.16591854
16MP0001881_abnormal_mammary_gland2.15932498
17MP0010678_abnormal_skin_adnexa2.14784004
18MP0003656_abnormal_erythrocyte_physiolo2.11620809
19MP0010234_abnormal_vibrissa_follicle2.03089710
20MP0002133_abnormal_respiratory_system1.98169746
21MP0005388_respiratory_system_phenotype1.98169746
22MP0005623_abnormal_meninges_morphology1.97154319
23MP0005165_increased_susceptibility_to1.97103760
24MP0004133_heterotaxia1.83417820
25MP0000566_synostosis1.72040657
26MP0002168_other_aberrant_phenotype1.70025624
27MP0005503_abnormal_tendon_morphology1.52552621
28MP0000465_gastrointestinal_hemorrhage1.46556914
29MP0001765_abnormal_ion_homeostasis1.45866918
30MP0000681_abnormal_thyroid_gland1.40972518
31MP0010155_abnormal_intestine_physiology1.39937516
32MP0005499_abnormal_olfactory_system1.39568108
33MP0005394_taste/olfaction_phenotype1.39568108
34MP0003566_abnormal_cell_adhesion1.38088565
35MP0005164_abnormal_response_to1.37905569
36MP0005085_abnormal_gallbladder_physiolo1.32042188
37MP0005023_abnormal_wound_healing1.29876692
38MP0002405_respiratory_system_inflammati1.25440796
39MP0001666_abnormal_nutrient_absorption1.23555361
40MP0004264_abnormal_extraembryonic_tissu1.21159219
41MP0003453_abnormal_keratinocyte_physiol1.19712650
42MP0005636_abnormal_mineral_homeostasis1.18901390
43MP0003303_peritoneal_inflammation1.16863982
44MP0009643_abnormal_urine_homeostasis1.16653123
45MP0010352_gastrointestinal_tract_polyps1.16076461
46MP0005365_abnormal_bile_salt1.12479437
47MP0005395_other_phenotype1.09358007
48MP0002282_abnormal_trachea_morphology1.07996045
49MP0000678_abnormal_parathyroid_gland1.07740857
50MP0005058_abnormal_lysosome_morphology1.07272514
51MP0000627_abnormal_mammary_gland1.02916770
52MP0001790_abnormal_immune_system1.01258628
53MP0005387_immune_system_phenotype1.01258628
54MP0001851_eye_inflammation1.00047455
55MP0006082_CNS_inflammation0.97967610
56MP0004883_abnormal_blood_vessel0.95747259
57MP0002909_abnormal_adrenal_gland0.95672910
58MP0003191_abnormal_cellular_cholesterol0.95110517
59MP0005275_abnormal_skin_tensile0.95083549
60MP0002148_abnormal_hypersensitivity_rea0.94729125
61MP0001346_abnormal_lacrimal_gland0.94467675
62MP0001664_abnormal_digestion0.91887464
63MP0002136_abnormal_kidney_physiology0.89509793
64MP0001849_ear_inflammation0.87167508
65MP0003724_increased_susceptibility_to0.86250167
66MP0003448_altered_tumor_morphology0.81240650
67MP0005377_hearing/vestibular/ear_phenot0.80439252
68MP0003878_abnormal_ear_physiology0.80439252
69MP0005025_abnormal_response_to0.79936580
70MP0003075_altered_response_to0.78608537
71MP0000858_altered_metastatic_potential0.70227479
72MP0002896_abnormal_bone_mineralization0.69742028
73MP0005408_hypopigmentation0.69459405
74MP0005166_decreased_susceptibility_to0.67678879
75MP0001502_abnormal_circadian_rhythm0.67408798
76MP0001756_abnormal_urination0.65001481
77MP0001879_abnormal_lymphatic_vessel0.62767287
78MP0010368_abnormal_lymphatic_system0.62573165
79MP0003786_premature_aging0.61872019
80MP0003300_gastrointestinal_ulcer0.60730935
81MP0002098_abnormal_vibrissa_morphology0.59596283
82MP0003091_abnormal_cell_migration0.58854085
83MP0003638_abnormal_response/metabolism_0.57806612
84MP0001835_abnormal_antigen_presentation0.57450633
85MP0009763_increased_sensitivity_to0.57002951
86MP0002876_abnormal_thyroid_physiology0.57002143
87MP0009765_abnormal_xenobiotic_induced0.55959254
88MP0005248_abnormal_Harderian_gland0.53973188
89MP0002160_abnormal_reproductive_system0.52331447
90MP0003690_abnormal_glial_cell0.51748481
91MP0001542_abnormal_bone_strength0.51054712
92MP0000249_abnormal_blood_vessel0.49125056
93MP0003436_decreased_susceptibility_to0.48504075
94MP0005220_abnormal_exocrine_pancreas0.48001108
95MP0003828_pulmonary_edema0.47304227
96MP0002135_abnormal_kidney_morphology0.47225713
97MP0002118_abnormal_lipid_homeostasis0.47012174
98MP0003866_abnormal_defecation0.46306255
99MP0002796_impaired_skin_barrier0.45173108
100MP0001270_distended_abdomen0.44625577

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.96496069
2Absent/shortened dynein arms (HP:0200106)9.96496069
3Rhinitis (HP:0012384)9.47383865
4Chronic bronchitis (HP:0004469)8.29319715
5Bronchiectasis (HP:0002110)7.18258220
6Nasal polyposis (HP:0100582)6.47549294
7Abnormality of the nasal mucosa (HP:0000433)5.44063841
8Bronchitis (HP:0012387)4.66114051
9Interstitial pulmonary disease (HP:0006530)4.53665700
10Hyperactive renin-angiotensin system (HP:0000841)4.31516947
11Recurrent sinusitis (HP:0011108)4.30672518
12Infertility (HP:0000789)3.96258677
13Chronic sinusitis (HP:0011109)3.88995371
14Recurrent otitis media (HP:0000403)3.76055788
15Male infertility (HP:0003251)3.70256224
16Tubulointerstitial nephritis (HP:0001970)3.28246160
17Tubulointerstitial fibrosis (HP:0005576)3.26175482
18Renal salt wasting (HP:0000127)3.13689046
19Chronic otitis media (HP:0000389)3.00838336
20Occipital encephalocele (HP:0002085)2.96357733
21Atelectasis (HP:0100750)2.87010599
22Decreased circulating renin level (HP:0003351)2.75325275
23Pancreatic fibrosis (HP:0100732)2.70259699
24True hermaphroditism (HP:0010459)2.63424644
25Tubulointerstitial abnormality (HP:0001969)2.58903989
26Hyperkalemia (HP:0002153)2.36864399
27Cystic liver disease (HP:0006706)2.29806864
28Hyperaldosteronism (HP:0000859)2.17360443
29Recurrent bronchitis (HP:0002837)2.16410158
30Absent frontal sinuses (HP:0002688)2.08830815
31Tubular atrophy (HP:0000092)2.08800277
32Pancreatic cysts (HP:0001737)2.08316786
33Abnormality of midbrain morphology (HP:0002418)2.07250122
34Molar tooth sign on MRI (HP:0002419)2.07250122
35Abnormality of chloride homeostasis (HP:0011422)2.04846993
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.5625991
37Abnormal respiratory motile cilium morphology (HP:0005938)10.3426094
38Abnormal respiratory epithelium morphology (HP:0012253)10.3426094
39Abnormal respiratory motile cilium physiology (HP:0012261)10.2249232
40Abnormal ciliary motility (HP:0012262)10.0309585
41Nephronophthisis (HP:0000090)1.99728063
42Hypokalemic alkalosis (HP:0001949)1.95540240
43Postaxial foot polydactyly (HP:0001830)1.92182277
44Abnormality of the renal medulla (HP:0100957)1.91716412
45Bell-shaped thorax (HP:0001591)1.90833927
46Abnormality of renin-angiotensin system (HP:0000847)1.88518168
47Cone-rod dystrophy (HP:0000548)1.82071150
48Chronic hepatic failure (HP:0100626)1.78934902
49Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.69253617
50Gout (HP:0001997)1.68271014
51Nephropathy (HP:0000112)1.65547737
52Congenital hepatic fibrosis (HP:0002612)1.65270294
53Hyponatremia (HP:0002902)1.60373973
54Abnormality of macular pigmentation (HP:0008002)1.51054342
55Male pseudohermaphroditism (HP:0000037)1.50145005
56Respiratory distress (HP:0002098)1.49642400
57Asplenia (HP:0001746)1.48047054
58Central scotoma (HP:0000603)1.45373357
59Glomerulonephritis (HP:0000099)1.43581497
60Aplasia/Hypoplasia of the tongue (HP:0010295)1.43446534
61Abnormality of the dental root (HP:0006486)1.43170499
62Taurodontia (HP:0000679)1.43170499
63Abnormality of permanent molar morphology (HP:0011071)1.43170499
64Complement deficiency (HP:0004431)1.42400557
65Aplasia/Hypoplasia of the spleen (HP:0010451)1.42213286
66Abnormality of monocarboxylic acid metabolism (HP:0010996)1.42032028
67Anencephaly (HP:0002323)1.41671267
68Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.39825358
69Hypotension (HP:0002615)1.39093731
70Abnormality of the dental pulp (HP:0006479)1.39052227
71Furrowed tongue (HP:0000221)1.37687671
72Tachypnea (HP:0002789)1.35695328
73Medial flaring of the eyebrow (HP:0010747)1.34700818
74Abnormality of the distal phalanges of the toes (HP:0010182)1.34464502
75Nephritis (HP:0000123)1.33929154
76Abnormality of the frontal sinuses (HP:0002687)1.33880545
77Abnormality of molar morphology (HP:0011070)1.33722171
78Abnormality of molar (HP:0011077)1.33722171
79Oculomotor apraxia (HP:0000657)1.32860212
80Congenital primary aphakia (HP:0007707)1.31825743
81Stage 5 chronic kidney disease (HP:0003774)1.29842615
82Abnormality of sodium homeostasis (HP:0010931)1.28945613
83Glucose intolerance (HP:0000833)1.27650161
84Scanning speech (HP:0002168)1.27185209
85Gait imbalance (HP:0002141)1.25389201
86Vascular calcification (HP:0004934)1.22756462
87Lip pit (HP:0100267)1.20732794
88Obstructive sleep apnea (HP:0002870)1.19708762
89Bifid scrotum (HP:0000048)1.16439199
90Flat acetabular roof (HP:0003180)1.14873077
91Short thorax (HP:0010306)1.14026750
92Adrenal overactivity (HP:0002717)1.13401763
93Postaxial hand polydactyly (HP:0001162)1.13088627
94Short nail (HP:0001799)1.12609520
95Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.12115981
96Nephrogenic diabetes insipidus (HP:0009806)1.11335970
97Abnormality of complement system (HP:0005339)1.10974595
98Abnormality of renal excretion (HP:0011036)1.08937059
99Abnormality of the renal cortex (HP:0011035)1.07994812
100Cardiovascular calcification (HP:0011915)1.07993352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.91391036
2EPHA25.42376570
3MST44.83904576
4MST1R4.31568810
5MAPKAPK32.79528480
6EPHA32.20534628
7MET2.14614798
8MAP3K22.09375190
9EEF2K2.01596780
10NME11.93930345
11EPHB11.92702744
12ZAP701.75417757
13LRRK21.74487221
14STK241.54169207
15BCR1.42216035
16TYK21.41325959
17NEK61.36164132
18MAP3K31.33896279
19NEK91.32989422
20FGFR31.25350192
21LATS11.25089970
22TRIB31.24876181
23CSK1.23150684
24SMG11.21135001
25STK101.15303281
26PTK2B1.15209605
27TESK11.06453096
28TBK11.05759207
29FGFR41.05625692
30TRPM71.04426096
31RIPK11.03518735
32TTK0.98866683
33STK380.98580418
34FER0.93831225
35PDGFRB0.91808898
36MAP3K120.91681552
37CDC42BPA0.87750056
38RIPK40.86748861
39NLK0.82809334
40CAMKK10.81968140
41STK38L0.80734213
42YES10.80433126
43LMTK20.77574152
44CDK60.73270714
45MARK20.73140647
46PAK40.71388783
47ERN10.68128018
48MAP3K70.67376539
49RET0.67227084
50BLK0.65711043
51IRAK10.65301467
52EIF2AK10.60841111
53ERBB30.60694980
54HIPK20.60135575
55BRSK20.59914271
56ICK0.57622636
57PRKCD0.55746322
58MYLK0.55092317
59PDPK10.54783142
60ERBB20.54142296
61MAP2K60.49141282
62JAK10.47962175
63IGF1R0.47683917
64LATS20.46683838
65MAPKAPK50.46229591
66PTK20.45147360
67DMPK0.41467074
68EGFR0.41136099
69ROCK20.40638262
70BMX0.40044316
71PNCK0.39474581
72ABL10.39001715
73PTK60.38572711
74PRKCI0.38119716
75MAP3K60.38087222
76RPS6KB20.37278094
77PRKCQ0.36967905
78RPS6KA20.36139530
79CASK0.34400466
80CAMK2G0.33399594
81MAP3K130.30912715
82SGK10.30613894
83MAP3K140.28399599
84CAMKK20.27912448
85PKN20.27807944
86ROCK10.27597415
87PRKAA20.27552271
88SRC0.27382144
89MAP3K10.23946960
90DYRK1B0.22499946
91FYN0.22242101
92NTRK10.19954195
93PRKD10.19815473
94PDK10.18753767
95GRK10.16248997
96TAOK10.16163453
97JAK20.14951369
98TGFBR20.14504608
99CHUK0.14362475
100AKT20.13922460

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.25334338
2Histidine metabolism_Homo sapiens_hsa003403.71467371
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.26416278
4Asthma_Homo sapiens_hsa053103.23420977
5Autoimmune thyroid disease_Homo sapiens_hsa053203.04856474
6Phenylalanine metabolism_Homo sapiens_hsa003603.03223346
7Allograft rejection_Homo sapiens_hsa053302.89151978
8Staphylococcus aureus infection_Homo sapiens_hsa051502.73560182
9Graft-versus-host disease_Homo sapiens_hsa053322.63558150
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.55008096
11Chemical carcinogenesis_Homo sapiens_hsa052042.46447051
12Type I diabetes mellitus_Homo sapiens_hsa049402.43855578
13Tyrosine metabolism_Homo sapiens_hsa003502.23999859
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.11880475
15beta-Alanine metabolism_Homo sapiens_hsa004101.96615472
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88934588
17Antigen processing and presentation_Homo sapiens_hsa046121.78755584
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.71937887
19Lysosome_Homo sapiens_hsa041421.65942928
20Complement and coagulation cascades_Homo sapiens_hsa046101.64686026
21Viral myocarditis_Homo sapiens_hsa054161.64297075
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.52949497
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52371359
24Glutathione metabolism_Homo sapiens_hsa004801.50763530
25Sphingolipid metabolism_Homo sapiens_hsa006001.47260648
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46304480
27Phagosome_Homo sapiens_hsa041451.43227817
28Fatty acid biosynthesis_Homo sapiens_hsa000611.34771036
29Leishmaniasis_Homo sapiens_hsa051401.34120474
30* Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26096308
31* Starch and sucrose metabolism_Homo sapiens_hsa005001.21715090
32Tight junction_Homo sapiens_hsa045301.13332319
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12684228
34Retinol metabolism_Homo sapiens_hsa008301.12548368
35Circadian rhythm_Homo sapiens_hsa047101.10497242
36ABC transporters_Homo sapiens_hsa020101.06529402
37Rheumatoid arthritis_Homo sapiens_hsa053231.06447389
38Mineral absorption_Homo sapiens_hsa049781.00802608
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.00026256
40Linoleic acid metabolism_Homo sapiens_hsa005910.98528067
41Hematopoietic cell lineage_Homo sapiens_hsa046400.94865768
42* Salivary secretion_Homo sapiens_hsa049700.93738401
43Huntingtons disease_Homo sapiens_hsa050160.91584586
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.89170836
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86579388
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86275511
47Toxoplasmosis_Homo sapiens_hsa051450.82426191
48Peroxisome_Homo sapiens_hsa041460.80011372
49Fatty acid degradation_Homo sapiens_hsa000710.79559917
50Hepatitis C_Homo sapiens_hsa051600.79495353
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.77205396
52Pertussis_Homo sapiens_hsa051330.76469658
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.73750150
54Influenza A_Homo sapiens_hsa051640.72955877
55Adherens junction_Homo sapiens_hsa045200.71911540
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67700568
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67142575
58Arachidonic acid metabolism_Homo sapiens_hsa005900.63478927
59Tuberculosis_Homo sapiens_hsa051520.60971282
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.59010458
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.55637952
62ECM-receptor interaction_Homo sapiens_hsa045120.53284847
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50358152
64Choline metabolism in cancer_Homo sapiens_hsa052310.47593653
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43460548
66Notch signaling pathway_Homo sapiens_hsa043300.43458595
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41523694
68Pancreatic secretion_Homo sapiens_hsa049720.39313901
69Herpes simplex infection_Homo sapiens_hsa051680.39303196
70Amoebiasis_Homo sapiens_hsa051460.38942931
71Other glycan degradation_Homo sapiens_hsa005110.38936752
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.37558028
73PPAR signaling pathway_Homo sapiens_hsa033200.37439770
74Systemic lupus erythematosus_Homo sapiens_hsa053220.31391954
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30694579
76Galactose metabolism_Homo sapiens_hsa000520.30168429
77Taste transduction_Homo sapiens_hsa047420.29982405
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.29789854
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29611868
80Arginine and proline metabolism_Homo sapiens_hsa003300.25033108
81Malaria_Homo sapiens_hsa051440.24988258
82Thyroid hormone synthesis_Homo sapiens_hsa049180.24911144
83Protein digestion and absorption_Homo sapiens_hsa049740.24910771
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23393695
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20267838
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20210566
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17003134
88Glycerolipid metabolism_Homo sapiens_hsa005610.16507613
89Bile secretion_Homo sapiens_hsa049760.15992969
90Endocytosis_Homo sapiens_hsa041440.15958719
91Vibrio cholerae infection_Homo sapiens_hsa051100.15343478
92Proteoglycans in cancer_Homo sapiens_hsa052050.14813945
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14805033
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.14168980
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13422344
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.13234262
97Pancreatic cancer_Homo sapiens_hsa052120.13125096
98Tryptophan metabolism_Homo sapiens_hsa003800.10460769
99Insulin resistance_Homo sapiens_hsa049310.09858681
100Apoptosis_Homo sapiens_hsa042100.09819709

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