AMY2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of epidermal cell differentiation (GO:0045605)9.86215307
2membrane lipid catabolic process (GO:0046466)9.42992284
3glycolipid catabolic process (GO:0019377)9.37983531
4cholesterol catabolic process (GO:0006707)8.33721299
5sterol catabolic process (GO:0016127)8.33721299
6ceramide catabolic process (GO:0046514)7.95067532
7protein retention in ER lumen (GO:0006621)7.94607110
8neutrophil mediated immunity (GO:0002446)7.85464291
9negative regulation of epidermis development (GO:0045683)7.56267633
10peptidyl-proline hydroxylation (GO:0019511)7.38230920
11icosanoid secretion (GO:0032309)7.22062190
12arachidonic acid secretion (GO:0050482)7.22062190
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.15909700
14phosphatidylinositol acyl-chain remodeling (GO:0036149)6.90403775
15phosphatidylserine acyl-chain remodeling (GO:0036150)6.67768003
16phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.58635057
17icosanoid transport (GO:0071715)5.92664906
18fatty acid derivative transport (GO:1901571)5.92664906
19protein hydroxylation (GO:0018126)5.67528190
20myeloid leukocyte mediated immunity (GO:0002444)5.67465201
21cholesterol transport (GO:0030301)5.45778288
22sterol transport (GO:0015918)5.45778288
23tetrapyrrole metabolic process (GO:0033013)5.39819829
24regulation of keratinocyte differentiation (GO:0045616)5.35774662
25innate immune response in mucosa (GO:0002227)5.27989273
26sphingolipid catabolic process (GO:0030149)5.14217393
27regulation of keratinocyte proliferation (GO:0010837)5.13779552
28digestive system process (GO:0022600)5.04068033
29phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.87258360
30leukotriene biosynthetic process (GO:0019370)4.78629888
31phospholipid catabolic process (GO:0009395)4.53270836
32phosphatidylserine metabolic process (GO:0006658)4.31712057
33mucosal immune response (GO:0002385)4.30202807
34cellular protein catabolic process (GO:0044257)4.20550281
35phosphatidylcholine acyl-chain remodeling (GO:0036151)4.12993828
36antibacterial humoral response (GO:0019731)4.09752389
37steroid catabolic process (GO:0006706)3.97247044
38phosphatidic acid biosynthetic process (GO:0006654)3.90903031
39phosphatidic acid metabolic process (GO:0046473)3.90903031
40organ or tissue specific immune response (GO:0002251)3.90020838
41water-soluble vitamin metabolic process (GO:0006767)3.85782137
42antimicrobial humoral response (GO:0019730)3.78236664
43defense response to Gram-positive bacterium (GO:0050830)3.64772172
44endothelial cell migration (GO:0043542)3.64008748
45polyketide metabolic process (GO:0030638)3.63329191
46doxorubicin metabolic process (GO:0044598)3.63329191
47daunorubicin metabolic process (GO:0044597)3.63329191
48alditol phosphate metabolic process (GO:0052646)3.55508926
49regulation of cholesterol homeostasis (GO:2000188)3.47104461
50acute-phase response (GO:0006953)3.39005647
51aminoglycoside antibiotic metabolic process (GO:0030647)3.36029964
52multicellular organismal catabolic process (GO:0044243)3.30684238
53negative regulation of epithelial cell differentiation (GO:0030857)3.30062958
54mitochondrial calcium ion transport (GO:0006851)3.29333929
55leukotriene metabolic process (GO:0006691)3.24847365
56phosphatidylglycerol metabolic process (GO:0046471)3.15352726
57retinoid metabolic process (GO:0001523)3.10314129
58regulation of epidermal cell differentiation (GO:0045604)3.04876282
59multicellular organismal metabolic process (GO:0044236)3.02524801
60intestinal cholesterol absorption (GO:0030299)27.3237870
61atrioventricular valve morphogenesis (GO:0003181)2.98891346
62regulation of acrosome reaction (GO:0060046)2.98618820
63diterpenoid metabolic process (GO:0016101)2.95752793
64cholesterol metabolic process (GO:0008203)2.93729137
65vitamin metabolic process (GO:0006766)2.93713343
66L-alpha-amino acid transmembrane transport (GO:1902475)2.82726093
67phototransduction, visible light (GO:0007603)2.80974090
68maintenance of protein localization in organelle (GO:0072595)2.80713558
69regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.79477405
70epithelial cell migration (GO:0010631)2.68164555
71positive regulation of wound healing (GO:0090303)2.67794049
72sterol metabolic process (GO:0016125)2.64042536
73negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.63353057
74extracellular matrix disassembly (GO:0022617)2.60766209
75alcohol catabolic process (GO:0046164)2.60112129
76terpenoid metabolic process (GO:0006721)2.58984696
77long-chain fatty acid transport (GO:0015909)2.58817990
78icosanoid biosynthetic process (GO:0046456)2.50466311
79fatty acid derivative biosynthetic process (GO:1901570)2.50466311
80mitochondrion distribution (GO:0048311)2.48831207
81regulation of bile acid biosynthetic process (GO:0070857)2.44484506
82lipid catabolic process (GO:0016042)2.40653093
83macroautophagy (GO:0016236)2.37908530
84detection of visible light (GO:0009584)2.36979993
85organic hydroxy compound transport (GO:0015850)2.31848106
86acute inflammatory response (GO:0002526)2.29969387
87phototransduction (GO:0007602)2.24723476
88positive regulation of calcium ion transport into cytosol (GO:0010524)2.22754258
89COPI coating of Golgi vesicle (GO:0048205)2.20651274
90Golgi transport vesicle coating (GO:0048200)2.20651274
91isoprenoid metabolic process (GO:0006720)2.17816925
92acid secretion (GO:0046717)2.17200124
93nucleotide-sugar biosynthetic process (GO:0009226)2.15933748
94exocrine pancreas development (GO:0031017)2.09863092
95positive regulation of fibroblast proliferation (GO:0048146)2.01049779
96* digestion (GO:0007586)17.4791641
97cobalamin metabolic process (GO:0009235)16.5033464
98transcytosis (GO:0045056)13.0112187
99intestinal absorption (GO:0050892)12.6131129
100regulation of phospholipase A2 activity (GO:0032429)10.9067564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.16323677
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.16323677
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.16323677
4FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.05490979
5EGR1_19032775_ChIP-ChIP_M12_Human2.86624678
6GATA4_25053715_ChIP-Seq_YYC3_Human2.34440762
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30346894
8PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.00753497
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat15.8180957
10ERG_21242973_ChIP-ChIP_JURKAT_Human1.85347311
11HTT_18923047_ChIP-ChIP_STHdh_Human1.73672325
12GATA6_25053715_ChIP-Seq_YYC3_Human1.70503302
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.58297921
14TCF4_18268006_ChIP-ChIP_LS174T_Human1.51038027
15ESR1_21235772_ChIP-Seq_MCF-7_Human1.50232973
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46965048
17PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.44428160
18CBX2_22325352_ChIP-Seq_293T-Rex_Human1.39479018
19PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.39410820
20* ETV1_20927104_ChIP-Seq_GIST48_Human1.37722110
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.34894451
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.33457803
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32718869
24* NFYA_21822215_ChIP-Seq_K562_Human1.31176914
25ESET_19884257_ChIP-Seq_ESCs_Mouse1.30950702
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30877284
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30704007
28FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29867995
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28782798
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.28533215
31NFYB_21822215_ChIP-Seq_K562_Human1.27681869
32FOXA1_25552417_ChIP-Seq_VCAP_Human1.26151383
33* HNFA_21074721_ChIP-Seq_CACO-2_Human1.24705521
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24259910
35* PHF8_20622853_ChIP-Seq_HELA_Human1.23356758
36FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21109080
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20877986
38* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19735877
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19002034
40AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18252926
41* RBPJ_21746931_ChIP-Seq_IB4_Human1.16413060
42* GATA6_21074721_ChIP-Seq_CACO-2_Human1.15205325
43SOX2_20726797_ChIP-Seq_SW620_Human1.14124901
44* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.12371320
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10639906
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.08710809
47JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04730222
48JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04334345
49TBL1_22424771_ChIP-Seq_293T_Human1.02925876
50RXR_22158963_ChIP-Seq_LIVER_Mouse0.98502681
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96228776
52TAF15_26573619_Chip-Seq_HEK293_Human0.95514584
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95121443
54CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92557511
55P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91663244
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91513694
57SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.90497862
58FOXA2_19822575_ChIP-Seq_HepG2_Human0.90246661
59TAF2_19829295_ChIP-Seq_ESCs_Human0.88759597
60REST_21632747_ChIP-Seq_MESCs_Mouse0.88262484
61CEBPB_22108803_ChIP-Seq_LS180_Human0.88141818
62SMAD4_21741376_ChIP-Seq_EPCs_Human0.86579859
63CBP_21632823_ChIP-Seq_H3396_Human0.85968303
64VDR_22108803_ChIP-Seq_LS180_Human0.84217485
65ERA_21632823_ChIP-Seq_H3396_Human0.84133614
66PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83499721
67GATA3_24758297_ChIP-Seq_MCF-7_Human0.82998835
68CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81925764
69TP53_16413492_ChIP-PET_HCT116_Human0.80218370
70TP53_18474530_ChIP-ChIP_U2OS_Human0.79671953
71ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78481092
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.77890687
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77265199
74FLI1_21867929_ChIP-Seq_CD8_Mouse0.77102081
75LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76510236
76PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76210288
77P300_19829295_ChIP-Seq_ESCs_Human0.75709651
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74717453
79SMAD_19615063_ChIP-ChIP_OVARY_Human0.74197857
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.71659720
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71645905
82CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.71077516
83SOX2_21211035_ChIP-Seq_LN229_Human0.70747965
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.70681623
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.70528772
86FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69902085
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.68977934
88GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.68940546
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67606362
90LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.67256374
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.66836746
92SA1_27219007_Chip-Seq_Bcells_Human0.66807623
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.65913391
94GATA1_22025678_ChIP-Seq_K562_Human0.65849707
95GATA3_21867929_ChIP-Seq_CD8_Mouse0.65752673
96CDX2_22108803_ChIP-Seq_LS180_Human0.65662881
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64800406
98FOXM1_26456572_ChIP-Seq_MCF-7_Human0.64181563
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.63686247
100CJUN_26792858_Chip-Seq_BT549_Human0.63659106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003868_abnormal_feces_composition9.77588801
2MP0005365_abnormal_bile_salt7.61504652
3MP0003959_abnormal_lean_body4.06771406
4MP0005220_abnormal_exocrine_pancreas3.66124634
5MP0005083_abnormal_biliary_tract2.88752538
6MP0005448_abnormal_energy_balance2.09441303
7MP0001666_abnormal_nutrient_absorption13.5107676
8MP0003300_gastrointestinal_ulcer1.94602506
9MP0002693_abnormal_pancreas_physiology1.90364638
10MP0005085_abnormal_gallbladder_physiolo1.89827878
11MP0002118_abnormal_lipid_homeostasis1.64982252
12MP0010386_abnormal_urinary_bladder1.52132895
13MP0002138_abnormal_hepatobiliary_system1.45846859
14MP0010329_abnormal_lipoprotein_level1.41148575
15MP0005452_abnormal_adipose_tissue1.29493978
16MP0005084_abnormal_gallbladder_morpholo1.27865369
17MP0000613_abnormal_salivary_gland1.27651193
18MP0008004_abnormal_stomach_pH1.26213492
19MP0002163_abnormal_gland_morphology1.23294227
20MP0003195_calcinosis1.11211586
21MP0010234_abnormal_vibrissa_follicle1.07268257
22MP0002078_abnormal_glucose_homeostasis1.05612110
23MP0009780_abnormal_chondrocyte_physiolo1.03414125
24MP0002132_abnormal_respiratory_system1.02936730
25MP0003953_abnormal_hormone_level0.94945518
26MP0003045_fibrosis0.92050513
27MP0001944_abnormal_pancreas_morphology0.90268771
28MP0001502_abnormal_circadian_rhythm0.88414816
29MP0004264_abnormal_extraembryonic_tissu0.88298537
30MP0002928_abnormal_bile_duct0.83303358
31MP0000462_abnormal_digestive_system0.80524834
32MP0000598_abnormal_liver_morphology0.79836201
33MP0002876_abnormal_thyroid_physiology0.79816349
34MP0001664_abnormal_digestion0.76637859
35MP0001501_abnormal_sleep_pattern0.75312780
36MP0005379_endocrine/exocrine_gland_phen0.70164779
37MP0003943_abnormal_hepatobiliary_system0.70009082
38MP0005334_abnormal_fat_pad0.68182569
39MP0002277_abnormal_respiratory_mucosa0.67642417
40MP0004043_abnormal_pH_regulation0.65716811
41MP0002909_abnormal_adrenal_gland0.64164900
42MP0002139_abnormal_hepatobiliary_system0.62619817
43MP0002089_abnormal_postnatal_growth/wei0.62226772
44MP0003252_abnormal_bile_duct0.59276540
45MP0001731_abnormal_postnatal_growth0.58349745
46MP0003879_abnormal_hair_cell0.57908175
47MP0002970_abnormal_white_adipose0.56916976
48MP0003011_delayed_dark_adaptation0.47515994
49MP0008872_abnormal_physiological_respon0.47050975
50MP0004019_abnormal_vitamin_homeostasis0.45414126
51MP0010678_abnormal_skin_adnexa0.44894595
52MP0005377_hearing/vestibular/ear_phenot0.44777468
53MP0003878_abnormal_ear_physiology0.44777468
54MP0001756_abnormal_urination0.43323620
55MP0003329_amyloid_beta_deposits0.43205566
56MP0003866_abnormal_defecation0.42719768
57MP0008961_abnormal_basal_metabolism0.40665216
58MP0008995_early_reproductive_senescence0.40349988
59MP0003283_abnormal_digestive_organ0.39653246
60MP0005332_abnormal_amino_acid0.38679815
61MP0003950_abnormal_plasma_membrane0.38573986
62MP0002168_other_aberrant_phenotype0.37237956
63MP0001765_abnormal_ion_homeostasis0.36766925
64MP0000470_abnormal_stomach_morphology0.36627970
65MP0004233_abnormal_muscle_weight0.35434000
66MP0001873_stomach_inflammation0.35292571
67MP0001845_abnormal_inflammatory_respons0.34480925
68MP0010352_gastrointestinal_tract_polyps0.33533356
69MP0005319_abnormal_enzyme/_coenzyme0.32412357
70MP0000003_abnormal_adipose_tissue0.32065064
71MP0008875_abnormal_xenobiotic_pharmacok0.31046039
72MP0009642_abnormal_blood_homeostasis0.30910752
73MP0000367_abnormal_coat/_hair0.29837012
74MP0003183_abnormal_peptide_metabolism0.29559614
75MP0008770_decreased_survivor_rate0.29337124
76MP0009840_abnormal_foam_cell0.27341072
77MP0002069_abnormal_eating/drinking_beha0.25678215
78MP0009384_cardiac_valve_regurgitation0.25231424
79MP0009643_abnormal_urine_homeostasis0.24880286
80MP0000013_abnormal_adipose_tissue0.23782957
81MP0003828_pulmonary_edema0.22850259
82MP0003956_abnormal_body_size0.21277976
83MP0000858_altered_metastatic_potential0.18949445
84MP0005410_abnormal_fertilization0.18666165
85MP0005451_abnormal_body_composition0.18604755
86MP0002822_catalepsy0.17907595
87MP0005636_abnormal_mineral_homeostasis0.17858947
88MP0002796_impaired_skin_barrier0.17240982
89MP0000432_abnormal_head_morphology0.16418624
90MP0001485_abnormal_pinna_reflex0.16034815
91MP0000383_abnormal_hair_follicle0.15361734
92MP0005166_decreased_susceptibility_to0.13315090
93MP0001177_atelectasis0.13167742
94MP0003566_abnormal_cell_adhesion0.11692606
95MP0000538_abnormal_urinary_bladder0.11633186
96MP0001784_abnormal_fluid_regulation0.10709576
97MP0000609_abnormal_liver_physiology0.09822052
98MP0004085_abnormal_heartbeat0.09399255
99MP0003123_paternal_imprinting0.09040643
100MP0009763_increased_sensitivity_to0.08517694

Predicted human phenotypes

RankGene SetZ-score
1Pancreatitis (HP:0001733)5.52528706
2Abnormality of the pleura (HP:0002103)3.91541897
3Abnormal pancreas size (HP:0012094)3.67168170
4Ileus (HP:0002595)3.36996162
5Rectal prolapse (HP:0002035)3.24386377
6Male infertility (HP:0003251)3.18123506
7Steatorrhea (HP:0002570)21.0412104
8Anal atresia (HP:0002023)2.89369760
9Large for gestational age (HP:0001520)2.84742522
10Tetraparesis (HP:0002273)2.79268745
11Vascular calcification (HP:0004934)2.54028377
12Abnormality of the pons (HP:0007361)2.51076355
13Hydroxyprolinuria (HP:0003080)2.29254444
14Abnormality of proline metabolism (HP:0010907)2.29254444
15Abnormal biliary tract morphology (HP:0012440)2.27419095
16Cardiovascular calcification (HP:0011915)2.17389245
17Popliteal pterygium (HP:0009756)2.15045222
18Type II lissencephaly (HP:0007260)2.08948440
19Abnormality of methionine metabolism (HP:0010901)2.04584059
20Fat malabsorption (HP:0002630)16.3234783
21Exocrine pancreatic insufficiency (HP:0001738)12.0839839
22Hypoproteinemia (HP:0003075)12.0659007
23Cerebellar dysplasia (HP:0007033)1.98743962
24Hyperinsulinemic hypoglycemia (HP:0000825)1.98260901
25Hypoglycemic seizures (HP:0002173)1.94678880
26Late onset (HP:0003584)1.92554075
27Abnormality of the right ventricle (HP:0001707)1.91775937
28Insulin-resistant diabetes mellitus (HP:0000831)1.91552856
29Genetic anticipation (HP:0003743)1.90402439
30Hypoplasia of the pons (HP:0012110)1.87427834
31Right ventricular cardiomyopathy (HP:0011663)1.87047840
32Abnormality of chloride homeostasis (HP:0011422)1.86257786
33Abnormal sex determination (HP:0012244)1.78227115
34Sex reversal (HP:0012245)1.78227115
35Azoospermia (HP:0000027)1.75725120
36Double outlet right ventricle (HP:0001719)1.71839535
37Congenital malformation of the right heart (HP:0011723)1.71839535
38Facial shape deformation (HP:0011334)1.70361708
39Potter facies (HP:0002009)1.70361708
40Tubulointerstitial fibrosis (HP:0005576)1.69253565
41Abnormality of glutamine family amino acid metabolism (HP:0010902)1.67759300
42Villous atrophy (HP:0011473)1.67265214
43Abnormality of small intestinal villus morphology (HP:0011472)1.67265214
44Esophageal varix (HP:0002040)1.63667955
45Abnormality of the pancreatic islet cells (HP:0006476)1.59282713
46Abnormality of endocrine pancreas physiology (HP:0012093)1.59282713
47Abdominal pain (HP:0002027)1.58396269
48Abnormality of the nasal septum (HP:0000419)1.56823177
49Hypercalciuria (HP:0002150)1.56284274
50Hypoglycemic coma (HP:0001325)1.55131820
51Abnormality of aspartate family amino acid metabolism (HP:0010899)1.54612203
52Abnormality of sulfur amino acid metabolism (HP:0004339)1.53839364
53Hyperglycemia (HP:0003074)1.52852264
54Deformed sella turcica (HP:0002681)1.48772445
55Malnutrition (HP:0004395)1.47996224
56Portal hypertension (HP:0001409)1.46696924
57Hyperphosphatemia (HP:0002905)1.46430605
58Neoplasm of the heart (HP:0100544)1.42026362
59Ketoacidosis (HP:0001993)1.40810257
60Type I transferrin isoform profile (HP:0003642)1.39166626
61Abnormal protein glycosylation (HP:0012346)1.37722345
62Abnormal glycosylation (HP:0012345)1.37722345
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.37722345
64Abnormal protein N-linked glycosylation (HP:0012347)1.37722345
65Papillary thyroid carcinoma (HP:0002895)1.35990359
66Type I diabetes mellitus (HP:0100651)1.33107034
67Progressive cerebellar ataxia (HP:0002073)1.31690588
68EEG with generalized epileptiform discharges (HP:0011198)1.31627967
69Tubulointerstitial abnormality (HP:0001969)1.31452565
70Abnormality of the hepatic vasculature (HP:0006707)1.30792316
71Hypsarrhythmia (HP:0002521)1.30162628
72Lower limb hyperreflexia (HP:0002395)1.29897324
73Gowers sign (HP:0003391)1.29687027
74Axonal loss (HP:0003447)1.29610208
75Skin pits (HP:0100276)1.29297877
76Symptomatic seizures (HP:0011145)1.27891535
77Hypoplastic labia majora (HP:0000059)1.26847972
78Epileptiform EEG discharges (HP:0011182)1.26127709
79Enlarged kidneys (HP:0000105)1.22216808
80Abnormality of the renal cortex (HP:0011035)1.21849285
81Abnormality of the intrinsic pathway (HP:0010989)1.21202418
82Reduced antithrombin III activity (HP:0001976)1.19184982
83Tubular atrophy (HP:0000092)1.19070413
84Insulin resistance (HP:0000855)1.17942616
85Paraparesis (HP:0002385)1.17745217
86Abnormality of the labia majora (HP:0012881)1.16629545
87Abnormality of the distal phalanges of the toes (HP:0010182)1.16557284
88Dehydration (HP:0001944)1.16435091
89Abnormal spermatogenesis (HP:0008669)1.16394492
90Barrel-shaped chest (HP:0001552)1.16163098
91Anal stenosis (HP:0002025)1.14937552
92Glycosuria (HP:0003076)1.13783073
93Abnormality of urine glucose concentration (HP:0011016)1.13783073
94Neonatal death (HP:0003811)1.13266573
95Preauricular pit (HP:0004467)1.10510945
96Periauricular skin pits (HP:0100277)1.10510945
97Transposition of the great arteries (HP:0001669)1.09763858
98Abnormal connection of the cardiac segments (HP:0011545)1.09763858
99Abnormal ventriculo-arterial connection (HP:0011563)1.09763858
100Chronic hepatic failure (HP:0100626)1.08950339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK29.54678883
2EPHA24.70927261
3EIF2AK34.22957345
4MAP3K33.14493850
5TAOK32.83877519
6NME12.81203022
7MAP3K22.64125506
8NTRK32.63598123
9MST1R2.49622411
10EPHA32.16490374
11PDK22.11871607
12ERN11.93101944
13FRK1.81351050
14PRKG21.73702373
15IRAK11.64429049
16RIPK11.61793961
17GRK11.57359231
18NLK1.48422732
19INSRR1.37952236
20MAP3K71.27905391
21MAP3K121.11923290
22IRAK21.10267258
23STK391.07022035
24BMPR1B1.05514427
25MAPK151.05456049
26EPHB10.98919180
27MET0.98001679
28MAPKAPK30.97360011
29TRPM70.95993467
30FER0.94671528
31DAPK20.89826703
32TBK10.83674920
33TRIB30.74062105
34MAP2K20.69697564
35ACVR1B0.68562775
36SGK30.68550503
37PIM20.68444475
38SGK20.67793442
39MUSK0.65794362
40MAP3K10.61539005
41MAP3K90.61391623
42WNK40.58519399
43CDK190.57881628
44MELK0.57325156
45MARK20.56416732
46ROCK10.55738350
47PRKAA10.55180270
48STK380.54821938
49TNIK0.54717913
50CASK0.54305689
51MAP4K20.53424523
52PRKCE0.53410857
53PASK0.53354284
54STK160.53317616
55BCR0.52946823
56SGK4940.52897152
57SGK2230.52897152
58MAP2K10.50898107
59MAP3K40.50684229
60NEK60.50266850
61MST40.49039336
62MAP3K50.48032035
63ERBB40.46485060
64CAMK40.40456015
65CHUK0.39611352
66FGFR30.37916391
67PDPK10.37840979
68PAK30.37025962
69KSR10.36101785
70JAK10.35942289
71OXSR10.34325735
72BCKDK0.33524672
73PRKAA20.33393306
74TIE10.32984708
75HIPK20.31172814
76BMX0.29824506
77TAOK10.26014778
78MARK10.25699570
79MAPK10.24530734
80TESK10.24139558
81MAP2K60.23756143
82CSNK1G10.23446059
83RPS6KA20.23028939
84EEF2K0.22542135
85CDK80.22115783
86FGFR40.20703258
87DYRK1A0.20458378
88CSNK1A10.19230603
89PTK60.18800074
90PTK20.18481770
91PRKACA0.18295718
92MAPK30.17854430
93LRRK20.16586867
94ERBB20.16521186
95RPS6KB10.15298054
96PRKCA0.14570699
97RET0.14558567
98PDK10.13864559
99MTOR0.12541105
100SGK10.12000673

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049758.71015423
2Protein digestion and absorption_Homo sapiens_hsa049746.62241582
3Glycerolipid metabolism_Homo sapiens_hsa005614.08254353
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.33199570
5Steroid biosynthesis_Homo sapiens_hsa001002.28123238
6Renin-angiotensin system_Homo sapiens_hsa046142.21413633
7Vitamin digestion and absorption_Homo sapiens_hsa049772.16593372
8* Pancreatic secretion_Homo sapiens_hsa0497210.0618267
9Maturity onset diabetes of the young_Homo sapiens_hsa049501.87148693
10Linoleic acid metabolism_Homo sapiens_hsa005911.85276709
11Ether lipid metabolism_Homo sapiens_hsa005651.18273096
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88282317
13Arachidonic acid metabolism_Homo sapiens_hsa005900.84687451
14Circadian rhythm_Homo sapiens_hsa047100.75447533
15Notch signaling pathway_Homo sapiens_hsa043300.74176958
16* Starch and sucrose metabolism_Homo sapiens_hsa005000.67143720
17Influenza A_Homo sapiens_hsa051640.63240831
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52750124
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47941179
20* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46893539
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43192624
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39075172
23Glycerophospholipid metabolism_Homo sapiens_hsa005640.38368188
24Vitamin B6 metabolism_Homo sapiens_hsa007500.34816686
25Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34646149
26Histidine metabolism_Homo sapiens_hsa003400.32903372
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30954811
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29977412
29Bile secretion_Homo sapiens_hsa049760.29175944
30Vascular smooth muscle contraction_Homo sapiens_hsa042700.28421943
31Protein export_Homo sapiens_hsa030600.28291469
32Steroid hormone biosynthesis_Homo sapiens_hsa001400.27366059
33Glutathione metabolism_Homo sapiens_hsa004800.25778748
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24347945
35Vibrio cholerae infection_Homo sapiens_hsa051100.23924227
36Chemical carcinogenesis_Homo sapiens_hsa052040.23774891
37ABC transporters_Homo sapiens_hsa020100.20763140
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20417195
39Insulin secretion_Homo sapiens_hsa049110.19267008
40N-Glycan biosynthesis_Homo sapiens_hsa005100.19009472
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18688160
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.16499185
43Sulfur metabolism_Homo sapiens_hsa009200.15554685
44Selenocompound metabolism_Homo sapiens_hsa004500.15378123
45Retinol metabolism_Homo sapiens_hsa008300.13392257
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.11823609
47Tight junction_Homo sapiens_hsa045300.11066586
48Sphingolipid metabolism_Homo sapiens_hsa006000.10000896
49* Metabolic pathways_Homo sapiens_hsa011000.09815528
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.09809263
51Ovarian steroidogenesis_Homo sapiens_hsa049130.09116589
52Hepatitis C_Homo sapiens_hsa051600.09093539
53Ras signaling pathway_Homo sapiens_hsa040140.08707932
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08471935
55Phototransduction_Homo sapiens_hsa047440.07500805
56Tryptophan metabolism_Homo sapiens_hsa003800.07353408
57Adherens junction_Homo sapiens_hsa045200.05961731
58Fatty acid degradation_Homo sapiens_hsa000710.05171733
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.04919780
60Mineral absorption_Homo sapiens_hsa049780.04299020
61beta-Alanine metabolism_Homo sapiens_hsa004100.03181455
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.02600563
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.02130176
64Butanoate metabolism_Homo sapiens_hsa006500.01822210
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.01348775
66Complement and coagulation cascades_Homo sapiens_hsa046100.00442721
67Arginine and proline metabolism_Homo sapiens_hsa003300.00387946
68Viral carcinogenesis_Homo sapiens_hsa05203-0.1181042
69Hippo signaling pathway_Homo sapiens_hsa04390-0.1170535
70cAMP signaling pathway_Homo sapiens_hsa04024-0.1169924
71Epstein-Barr virus infection_Homo sapiens_hsa05169-0.1133680
72Collecting duct acid secretion_Homo sapiens_hsa04966-0.1086741
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.1066462
74Primary bile acid biosynthesis_Homo sapiens_hsa00120-0.1040439
75MAPK signaling pathway_Homo sapiens_hsa04010-0.1031025
76TGF-beta signaling pathway_Homo sapiens_hsa04350-0.1021212
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210-0.0980589
78Insulin resistance_Homo sapiens_hsa04931-0.0970855
79TNF signaling pathway_Homo sapiens_hsa04668-0.0965035
80Estrogen signaling pathway_Homo sapiens_hsa04915-0.0940375
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0912786
82Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0906708
83Taste transduction_Homo sapiens_hsa04742-0.0906450
84Cocaine addiction_Homo sapiens_hsa05030-0.0862924
85Salivary secretion_Homo sapiens_hsa04970-0.0850011
86Endometrial cancer_Homo sapiens_hsa05213-0.0840072
87Prolactin signaling pathway_Homo sapiens_hsa04917-0.0819384
88GABAergic synapse_Homo sapiens_hsa04727-0.0730444
89Type II diabetes mellitus_Homo sapiens_hsa04930-0.0719257
90Thyroid cancer_Homo sapiens_hsa05216-0.0700354
91Peroxisome_Homo sapiens_hsa04146-0.0611450
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0604296
93Other glycan degradation_Homo sapiens_hsa00511-0.0533457
94ErbB signaling pathway_Homo sapiens_hsa04012-0.0501748
95FoxO signaling pathway_Homo sapiens_hsa04068-0.0462787
96Gastric acid secretion_Homo sapiens_hsa04971-0.0309177
97Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0295706
98Regulation of autophagy_Homo sapiens_hsa04140-0.0128473
99Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0081043
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0020702

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