AMZ2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc metalloprotease that displays some activity against angiotensin-3. The encoded protein is inhibited by the aminopeptidase inhibitor amastatin, as well as by the general inhibitors o-phenanthroline and batimastat. Defects in this gene may be associated with lung tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.97478802
2sperm motility (GO:0030317)8.71117662
3fusion of sperm to egg plasma membrane (GO:0007342)8.62839443
4acrosome assembly (GO:0001675)7.92555874
5sperm-egg recognition (GO:0035036)7.47795345
6cell wall macromolecule catabolic process (GO:0016998)7.37820840
7cell wall macromolecule metabolic process (GO:0044036)7.37820840
8epithelial cilium movement (GO:0003351)7.21010915
9binding of sperm to zona pellucida (GO:0007339)7.11769945
10acrosome reaction (GO:0007340)6.83791655
11axonemal dynein complex assembly (GO:0070286)6.70467949
12plasma membrane fusion (GO:0045026)6.62213251
13cell-cell recognition (GO:0009988)6.59031868
14multicellular organism reproduction (GO:0032504)6.57390804
15spermatid development (GO:0007286)6.48519075
16cilium movement (GO:0003341)6.09466698
17piRNA metabolic process (GO:0034587)6.07112320
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.03779854
19motile cilium assembly (GO:0044458)5.98423473
20regulation of cilium movement (GO:0003352)5.56453654
21reproduction (GO:0000003)5.50839273
22male meiosis (GO:0007140)5.33464824
23synaptonemal complex organization (GO:0070193)5.26302947
24synaptonemal complex assembly (GO:0007130)5.10954088
25cullin deneddylation (GO:0010388)4.82685042
26sperm capacitation (GO:0048240)4.69317004
27single fertilization (GO:0007338)4.55782385
28protein deneddylation (GO:0000338)4.49254366
29negative regulation of inclusion body assembly (GO:0090084)4.24853503
30microtubule depolymerization (GO:0007019)4.18774905
31regulation of microtubule-based movement (GO:0060632)4.18529372
32positive regulation of mitochondrial fission (GO:0090141)4.16058353
33calcium ion-dependent exocytosis (GO:0017156)4.08524526
34spermatogenesis (GO:0007283)4.07340704
35male gamete generation (GO:0048232)4.05977109
36left/right pattern formation (GO:0060972)3.99358352
37ventricular system development (GO:0021591)3.93657281
38cell recognition (GO:0008037)3.89359566
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87491959
40DNA methylation involved in gamete generation (GO:0043046)3.85632992
41fertilization (GO:0009566)3.85140167
42pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.84683673
43proteasome assembly (GO:0043248)3.83148837
44base-excision repair, AP site formation (GO:0006285)3.74128284
45microtubule severing (GO:0051013)3.73705550
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.73115128
47NADH dehydrogenase complex assembly (GO:0010257)3.73115128
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.73115128
49protein complex biogenesis (GO:0070271)3.70100018
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.69610927
51gamete generation (GO:0007276)3.68749261
52cellular process involved in reproduction in multicellular organism (GO:0022412)3.61021708
53pyrimidine nucleobase catabolic process (GO:0006208)3.60449567
54protein neddylation (GO:0045116)3.60444612
55pyrimidine nucleotide catabolic process (GO:0006244)3.57163945
56germ cell development (GO:0007281)3.54869055
57intraciliary transport (GO:0042073)3.54044934
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.51216520
59mitochondrial respiratory chain complex assembly (GO:0033108)3.48420447
60regulation of inclusion body assembly (GO:0090083)3.47641119
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.46931476
62chromosome organization involved in meiosis (GO:0070192)3.44739460
63male meiosis I (GO:0007141)3.44526427
64respiratory chain complex IV assembly (GO:0008535)3.43969763
65spermatid nucleus differentiation (GO:0007289)3.39232134
66seminiferous tubule development (GO:0072520)3.37332834
67respiratory electron transport chain (GO:0022904)3.31374968
68protein localization to cilium (GO:0061512)3.29965994
69layer formation in cerebral cortex (GO:0021819)3.29567217
70negative regulation of organelle assembly (GO:1902116)3.28723480
71electron transport chain (GO:0022900)3.27446470
72ATP synthesis coupled proton transport (GO:0015986)3.26488848
73energy coupled proton transport, down electrochemical gradient (GO:0015985)3.26488848
74water-soluble vitamin biosynthetic process (GO:0042364)3.20878065
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19069963
76anterograde synaptic vesicle transport (GO:0048490)3.17538622
77monoubiquitinated protein deubiquitination (GO:0035520)3.16768604
78microtubule-based movement (GO:0007018)3.16691418
79meiotic nuclear division (GO:0007126)3.14566590
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10467698
81chaperone-mediated protein transport (GO:0072321)3.07017838
82amino acid salvage (GO:0043102)3.04027517
83L-methionine salvage (GO:0071267)3.04027517
84L-methionine biosynthetic process (GO:0071265)3.04027517
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03993991
86regulation of mitotic spindle checkpoint (GO:1903504)3.03993991
87DNA double-strand break processing (GO:0000729)3.00009059
88protein K6-linked ubiquitination (GO:0085020)2.99622512
89tricarboxylic acid cycle (GO:0006099)2.96500104
90anterograde axon cargo transport (GO:0008089)2.93659025
91organelle disassembly (GO:1903008)2.93242511
92protein K11-linked ubiquitination (GO:0070979)2.91283544
93succinate metabolic process (GO:0006105)2.90812179
94organic cation transport (GO:0015695)2.90778405
95RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90429140
96tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90429140
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89834870
98multicellular organismal reproductive process (GO:0048609)2.89160733
99glycerol ether metabolic process (GO:0006662)2.88966257
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.88868230
101termination of RNA polymerase III transcription (GO:0006386)2.88868230
102protein polyglutamylation (GO:0018095)2.86970392
103nonmotile primary cilium assembly (GO:0035058)2.86336780
104cytochrome complex assembly (GO:0017004)2.85883478
105positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84516665
106regulation of cellular amino acid metabolic process (GO:0006521)2.83309274
107platelet dense granule organization (GO:0060155)2.81505132
108positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.79655011
109meiosis I (GO:0007127)2.78410704
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77960749
111iron-sulfur cluster assembly (GO:0016226)2.75162595
112metallo-sulfur cluster assembly (GO:0031163)2.75162595
113gene silencing by RNA (GO:0031047)2.73721086
114response to redox state (GO:0051775)2.73645892
115ribonucleoprotein complex disassembly (GO:0032988)2.73266367
116positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.71171203
117mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.67533591
118positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.67533591
119preassembly of GPI anchor in ER membrane (GO:0016254)2.66320983
120axoneme assembly (GO:0035082)2.65484830
121regulation of mitochondrial fission (GO:0090140)2.62566296
122nucleobase catabolic process (GO:0046113)2.62293921
123protein localization to synapse (GO:0035418)2.62196286
124protein-cofactor linkage (GO:0018065)2.61979159
125protein localization to mitochondrion (GO:0070585)2.61950950
126GTP biosynthetic process (GO:0006183)2.60875851
127protein refolding (GO:0042026)2.59976399
128ubiquinone biosynthetic process (GO:0006744)2.59617938
129DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.59267790
130mannosylation (GO:0097502)2.59065564
131nucleoside diphosphate phosphorylation (GO:0006165)2.58901830
132regulation of mitochondrial translation (GO:0070129)2.58124699
133genitalia morphogenesis (GO:0035112)2.58015384
134negative regulation of ligase activity (GO:0051352)2.57537887
135negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.57537887
136cellular component assembly involved in morphogenesis (GO:0010927)2.56515597
137anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.56426791
138ether metabolic process (GO:0018904)2.56184854
139pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.56073399
140multicellular organismal development (GO:0007275)2.55783013
1417-methylguanosine mRNA capping (GO:0006370)2.55458391
142positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.55342601
143protein targeting to mitochondrion (GO:0006626)2.55220480
144signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53884202
145signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53884202
146signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53884202
147peptidyl-histidine modification (GO:0018202)2.53576474
148establishment of protein localization to mitochondrion (GO:0072655)2.51674739
149DNA damage response, detection of DNA damage (GO:0042769)2.51336862
150intracellular protein transmembrane import (GO:0044743)2.50919146
151cilium organization (GO:0044782)2.50808294
152deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.50148331
153peptidyl-arginine omega-N-methylation (GO:0035247)2.50083378
154intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.49877274
155signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.49877274
156meiotic cell cycle (GO:0051321)2.49247714
157neuronal action potential propagation (GO:0019227)2.48112491
158histone arginine methylation (GO:0034969)2.47681432
159C-terminal protein amino acid modification (GO:0018410)2.46484439
1607-methylguanosine RNA capping (GO:0009452)2.46467774
161RNA capping (GO:0036260)2.46467774
162mitotic sister chromatid cohesion (GO:0007064)2.46345773
163cilium assembly (GO:0042384)2.45856610
164aspartate family amino acid biosynthetic process (GO:0009067)2.45734933
165peptidyl-lysine dimethylation (GO:0018027)2.44407019
166calcium ion import (GO:0070509)2.43135103
167lactate metabolic process (GO:0006089)2.42261300
168chaperone-mediated protein complex assembly (GO:0051131)2.42150496
169establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.39445570
170mitochondrion transport along microtubule (GO:0047497)2.39445570
171heart process (GO:0003015)2.38109890
172heart contraction (GO:0060047)2.38109890
173regulation of synapse structural plasticity (GO:0051823)2.37845002
174DNA packaging (GO:0006323)2.36233752
175guanosine-containing compound biosynthetic process (GO:1901070)2.36111489
176polyol catabolic process (GO:0046174)2.35504998
177synaptic vesicle docking involved in exocytosis (GO:0016081)2.35439989
178chromosome condensation (GO:0030261)2.35102222
179regulation of cilium assembly (GO:1902017)2.35040136
180positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.33955890
181glycolytic process (GO:0006096)2.33946676
182response to pheromone (GO:0019236)2.32978110
183cilium morphogenesis (GO:0060271)2.31598169
184histone exchange (GO:0043486)2.30664854
185negative regulation of potassium ion transmembrane transport (GO:1901380)2.30466673
186membrane depolarization during action potential (GO:0086010)2.29529029
187positive regulation of microtubule polymerization (GO:0031116)2.28379785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.92304103
2EZH2_22144423_ChIP-Seq_EOC_Human6.85989612
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.10213217
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08794968
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.36879515
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.31428366
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.27491584
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.21733130
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00744476
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00214149
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87177331
12ZNF274_21170338_ChIP-Seq_K562_Hela2.84923560
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.82117483
14ELK1_19687146_ChIP-ChIP_HELA_Human2.51014175
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45152141
16* VDR_23849224_ChIP-Seq_CD4+_Human2.44763666
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.42489430
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39188989
19* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27634597
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23867247
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23403920
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22025459
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17083023
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15406064
25IGF1R_20145208_ChIP-Seq_DFB_Human2.13364987
26STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12057502
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12007120
28REST_21632747_ChIP-Seq_MESCs_Mouse2.07125704
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.05395145
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.98147758
31* GABP_19822575_ChIP-Seq_HepG2_Human1.96759416
32FOXP3_21729870_ChIP-Seq_TREG_Human1.96066860
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93157885
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89565359
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.86777124
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.78970640
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.72788168
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70205967
39VDR_22108803_ChIP-Seq_LS180_Human1.66743116
40IRF1_19129219_ChIP-ChIP_H3396_Human1.65939638
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.62962333
42DCP1A_22483619_ChIP-Seq_HELA_Human1.62360808
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.60422712
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57052607
45CBP_20019798_ChIP-Seq_JUKART_Human1.57052607
46ELK4_26923725_Chip-Seq_MESODERM_Mouse1.53243812
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52258592
48FUS_26573619_Chip-Seq_HEK293_Human1.48351457
49SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.45652991
50EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45304605
51EWS_26573619_Chip-Seq_HEK293_Human1.43770478
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43694976
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43455484
54TTF2_22483619_ChIP-Seq_HELA_Human1.42533816
55* MYC_18940864_ChIP-ChIP_HL60_Human1.42234337
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.39058988
57TAF15_26573619_Chip-Seq_HEK293_Human1.38539277
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37391439
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37100887
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32715845
61TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.32131171
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29720361
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.29620922
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28290502
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27958574
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27733233
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25747704
68P300_19829295_ChIP-Seq_ESCs_Human1.25568039
69XRN2_22483619_ChIP-Seq_HELA_Human1.23889565
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21578364
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20231803
72* EZH2_27294783_Chip-Seq_ESCs_Mouse1.20166767
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.18118804
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17547038
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17202828
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15680584
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14603095
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11978886
79RNF2_27304074_Chip-Seq_NSC_Mouse1.11607134
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09861953
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.09567595
82SOX2_22085726_ChIP-Seq_NPCs_Mouse1.08550780
83DROSHA_22980978_ChIP-Seq_HELA_Human1.08488202
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07944291
85KDM5A_27292631_Chip-Seq_BREAST_Human1.07503069
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07445750
87GBX2_23144817_ChIP-Seq_PC3_Human1.06930536
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.05695119
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04920026
90GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.04670983
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.03807913
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03725857
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03407510
94* TP53_22573176_ChIP-Seq_HFKS_Human1.02860010
95HOXB7_26014856_ChIP-Seq_BT474_Human1.02810612
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.02382355
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02377232
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02318795
99KDM2B_26808549_Chip-Seq_REH_Human1.02300339
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02133046
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01367760
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01207764
103ELK1_22589737_ChIP-Seq_MCF10A_Human1.01194453
104* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01104957
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01059533
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01059533
107SOX9_26525672_Chip-Seq_HEART_Mouse1.01015451
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00663735
109POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00554242
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99410287
111NCOR_22424771_ChIP-Seq_293T_Human0.99337806
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.99078626
113FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98372211
114FOXA1_25329375_ChIP-Seq_VCAP_Human0.98372211
115RARB_27405468_Chip-Seq_BRAIN_Mouse0.96602663
116ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96368513
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93874730
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93373910
119MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93343098
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92031059
121EZH2_27304074_Chip-Seq_ESCs_Mouse0.91910649
122ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90740287
123SMAD4_21799915_ChIP-Seq_A2780_Human0.90238161
124CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89770621
125STAT1_17558387_ChIP-Seq_HELA_Human0.89070217
126ER_23166858_ChIP-Seq_MCF-7_Human0.88970169
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88387122
128* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88166391
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.87670253
130* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87482666
131CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87271628
132SOX2_19829295_ChIP-Seq_ESCs_Human0.86950687
133NANOG_19829295_ChIP-Seq_ESCs_Human0.86950687
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85669692
135RUNX1_26923725_Chip-Seq_HPCs_Mouse0.85555746
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84997802
137CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84858062
138GATA3_21878914_ChIP-Seq_MCF-7_Human0.84602146
139GATA3_21867929_ChIP-Seq_CD8_Mouse0.84574399
140CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84515404
141MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84215805
142TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83427446
143YY1_22570637_ChIP-Seq_MALME-3M_Human0.82854713
144TCF4_23295773_ChIP-Seq_U87_Human0.82695495
145POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82095339
146NANOG_18555785_Chip-Seq_ESCs_Mouse0.82082713
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81931845
148SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81324424
149CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81195095
150AR_20517297_ChIP-Seq_VCAP_Human0.80763883
151P53_22387025_ChIP-Seq_ESCs_Mouse0.80763878
152ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80722486
153P53_21459846_ChIP-Seq_SAOS-2_Human0.80593362
154ERG_20517297_ChIP-Seq_VCAP_Human0.80418939
155MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.80329870
156FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80239762
157TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80191865
158SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.79563944
159EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79022394
160SMAD4_21741376_ChIP-Seq_EPCs_Human0.77987705
161RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77910997
162CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.77909391
163NFIB_24661679_ChIP-Seq_LUNG_Mouse0.76911457
164NFE2_27457419_Chip-Seq_LIVER_Mouse0.76236713
165SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.75714645
166CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75494906
167YAP1_20516196_ChIP-Seq_MESCs_Mouse0.75473177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.18923486
2MP0003698_abnormal_male_reproductive3.53007476
3MP0003646_muscle_fatigue3.24896039
4MP0008877_abnormal_DNA_methylation3.23154412
5MP0001929_abnormal_gametogenesis3.08968970
6MP0009780_abnormal_chondrocyte_physiolo2.79875195
7MP0004233_abnormal_muscle_weight2.62023568
8MP0004859_abnormal_synaptic_plasticity2.54408350
9MP0001529_abnormal_vocalization2.41269941
10MP0002837_dystrophic_cardiac_calcinosis2.37971640
11MP0003011_delayed_dark_adaptation2.30140112
12MP0000751_myopathy2.23356186
13MP0004270_analgesia2.15626696
14MP0002210_abnormal_sex_determination2.10539762
15MP0002102_abnormal_ear_morphology2.00801427
16MP0008789_abnormal_olfactory_epithelium1.97037472
17MP0004145_abnormal_muscle_electrophysio1.96198781
18MP0002653_abnormal_ependyma_morphology1.87258371
19MP0002161_abnormal_fertility/fecundity1.84264030
20MP0005499_abnormal_olfactory_system1.80053151
21MP0005394_taste/olfaction_phenotype1.80053151
22MP0001145_abnormal_male_reproductive1.75188404
23MP0002272_abnormal_nervous_system1.74468264
24MP0003186_abnormal_redox_activity1.73807811
25MP0005645_abnormal_hypothalamus_physiol1.72518381
26MP0004130_abnormal_muscle_cell1.71590592
27MP0002938_white_spotting1.67874239
28MP0004036_abnormal_muscle_relaxation1.63017387
29MP0004084_abnormal_cardiac_muscle1.62718419
30MP0000778_abnormal_nervous_system1.60644803
31MP0002234_abnormal_pharynx_morphology1.57359080
32MP0001984_abnormal_olfaction1.55599131
33MP0003635_abnormal_synaptic_transmissio1.54713599
34MP0005083_abnormal_biliary_tract1.53858393
35MP0006072_abnormal_retinal_apoptosis1.53785034
36MP0004215_abnormal_myocardial_fiber1.53692115
37MP0003221_abnormal_cardiomyocyte_apopto1.53482357
38MP0000653_abnormal_sex_gland1.50352134
39MP0000749_muscle_degeneration1.49058910
40MP0005379_endocrine/exocrine_gland_phen1.47487943
41MP0002106_abnormal_muscle_physiology1.46994804
42MP0006035_abnormal_mitochondrial_morpho1.46592228
43MP0002163_abnormal_gland_morphology1.45141973
44MP0005646_abnormal_pituitary_gland1.44942452
45MP0005084_abnormal_gallbladder_morpholo1.44818993
46MP0005423_abnormal_somatic_nervous1.38831534
47MP0000372_irregular_coat_pigmentation1.38285176
48MP0002063_abnormal_learning/memory/cond1.37619713
49MP0006292_abnormal_olfactory_placode1.37215590
50MP0004811_abnormal_neuron_physiology1.36385490
51MP0002909_abnormal_adrenal_gland1.31184870
52MP0004087_abnormal_muscle_fiber1.30903518
53MP0005174_abnormal_tail_pigmentation1.29599745
54MP0002064_seizures1.28104235
55MP0001968_abnormal_touch/_nociception1.24896063
56MP0002160_abnormal_reproductive_system1.23743670
57MP0002735_abnormal_chemical_nociception1.23025692
58MP0000569_abnormal_digit_pigmentation1.20900287
59MP0001905_abnormal_dopamine_level1.20414685
60MP0002734_abnormal_mechanical_nocicepti1.20382409
61MP0005369_muscle_phenotype1.18618306
62MP0000759_abnormal_skeletal_muscle1.18098352
63MP0000427_abnormal_hair_cycle1.16925624
64MP0005620_abnormal_muscle_contractility1.16829834
65MP0004142_abnormal_muscle_tone1.16557773
66MP0002736_abnormal_nociception_after1.15446274
67MP0001486_abnormal_startle_reflex1.14521164
68MP0004043_abnormal_pH_regulation1.13158134
69MP0003787_abnormal_imprinting1.12265582
70MP0000013_abnormal_adipose_tissue1.12127375
71MP0003136_yellow_coat_color1.11183120
72MP0003880_abnormal_central_pattern1.10918730
73MP0005623_abnormal_meninges_morphology1.10642915
74MP0004147_increased_porphyrin_level1.07793846
75MP0001293_anophthalmia1.07442848
76MP0004133_heterotaxia1.05387291
77MP0000631_abnormal_neuroendocrine_gland1.03255075
78MP0005075_abnormal_melanosome_morpholog1.02944032
79MP0008932_abnormal_embryonic_tissue1.01860274
80MP0002184_abnormal_innervation1.01380962
81MP0005187_abnormal_penis_morphology1.00737556
82MP0000678_abnormal_parathyroid_gland1.00398653
83MP0002269_muscular_atrophy0.98454173
84MP0008007_abnormal_cellular_replicative0.98349437
85MP0002751_abnormal_autonomic_nervous0.97907465
86MP0002972_abnormal_cardiac_muscle0.97783031
87MP0003718_maternal_effect0.96349799
88MP0005253_abnormal_eye_physiology0.95781052
89MP0000955_abnormal_spinal_cord0.95087801
90MP0000750_abnormal_muscle_regeneration0.94755874
91MP0004085_abnormal_heartbeat0.93927842
92MP0002282_abnormal_trachea_morphology0.91703732
93MP0009046_muscle_twitch0.90464741
94MP0002752_abnormal_somatic_nervous0.90429741
95MP0003693_abnormal_embryo_hatching0.90154905
96MP0004484_altered_response_of0.88799648
97MP0005408_hypopigmentation0.88250643
98MP0002572_abnormal_emotion/affect_behav0.88189787
99MP0002876_abnormal_thyroid_physiology0.87769832
100MP0001502_abnormal_circadian_rhythm0.86822826
101MP0005389_reproductive_system_phenotype0.85604411
102MP0002152_abnormal_brain_morphology0.85095171
103MP0002638_abnormal_pupillary_reflex0.85013463
104MP0003137_abnormal_impulse_conducting0.84957174
105MP0003122_maternal_imprinting0.84606161
106MP0002229_neurodegeneration0.83955889
107MP0010386_abnormal_urinary_bladder0.83243277
108MP0002882_abnormal_neuron_morphology0.82678956
109MP0001348_abnormal_lacrimal_gland0.81683115
110MP0002233_abnormal_nose_morphology0.81253815
111MP0003861_abnormal_nervous_system0.80049241
112MP0002095_abnormal_skin_pigmentation0.79678943
113MP0005551_abnormal_eye_electrophysiolog0.79007926
114MP0003567_abnormal_fetal_cardiomyocyte0.78792013
115MP0002557_abnormal_social/conspecific_i0.78631306
116MP0001544_abnormal_cardiovascular_syste0.77828542
117MP0005385_cardiovascular_system_phenoty0.77828542
118MP0006036_abnormal_mitochondrial_physio0.77783923
119MP0000537_abnormal_urethra_morphology0.77236209
120MP0008872_abnormal_physiological_respon0.77212538
121MP0010630_abnormal_cardiac_muscle0.77086349
122MP0000015_abnormal_ear_pigmentation0.76696714
123MP0005248_abnormal_Harderian_gland0.74955109
124MP0008875_abnormal_xenobiotic_pharmacok0.74918528
125MP0009745_abnormal_behavioral_response0.74526998
126MP0001963_abnormal_hearing_physiology0.74229326
127MP0001346_abnormal_lacrimal_gland0.74024163
128MP0003123_paternal_imprinting0.73538946
129MP0003879_abnormal_hair_cell0.73115253
130MP0008058_abnormal_DNA_repair0.72708179
131MP0005330_cardiomyopathy0.71819492
132MP0003121_genomic_imprinting0.70958202
133MP0010094_abnormal_chromosome_stability0.70782969
134MP0006276_abnormal_autonomic_nervous0.69789824
135MP0002733_abnormal_thermal_nociception0.69267849
136MP0002067_abnormal_sensory_capabilities0.68591607
137MP0002877_abnormal_melanocyte_morpholog0.66988292
138MP0004858_abnormal_nervous_system0.66145144
139MP0006054_spinal_hemorrhage0.66030347
140MP0003283_abnormal_digestive_organ0.64966346
141MP0002127_abnormal_cardiovascular_syste0.64782728
142MP0000358_abnormal_cell_content/0.63862597
143MP0005386_behavior/neurological_phenoty0.63493462
144MP0004924_abnormal_behavior0.63493462
145MP0003119_abnormal_digestive_system0.63486292
146MP0001970_abnormal_pain_threshold0.61644022
147MP0002066_abnormal_motor_capabilities/c0.61442154

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.74676788
2Absent/shortened dynein arms (HP:0200106)8.74676788
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.39722015
4Abnormal respiratory motile cilium physiology (HP:0012261)6.14150682
5Abnormal respiratory epithelium morphology (HP:0012253)6.02387036
6Abnormal respiratory motile cilium morphology (HP:0005938)6.02387036
7Rhinitis (HP:0012384)5.35611569
8Chronic bronchitis (HP:0004469)4.90626936
9Abnormal ciliary motility (HP:0012262)4.87199227
10Infertility (HP:0000789)4.58609937
11Amyotrophic lateral sclerosis (HP:0007354)3.70437278
12Methylmalonic aciduria (HP:0012120)3.70142901
13Nasal polyposis (HP:0100582)3.53162156
14Acute encephalopathy (HP:0006846)3.53027322
15Mitochondrial inheritance (HP:0001427)3.43915947
16Increased CSF lactate (HP:0002490)3.36143666
17Pancreatic cysts (HP:0001737)3.30842997
18Hepatocellular necrosis (HP:0001404)3.30576656
19Hepatic necrosis (HP:0002605)3.25158979
20Progressive macrocephaly (HP:0004481)3.24973182
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21295082
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21295082
23Exercise-induced myalgia (HP:0003738)3.20493162
24Nephronophthisis (HP:0000090)3.19167961
25Hyperventilation (HP:0002883)3.12386237
26Nephrogenic diabetes insipidus (HP:0009806)3.11262307
27Methylmalonic acidemia (HP:0002912)3.10955571
28Pancreatic fibrosis (HP:0100732)3.08640784
29True hermaphroditism (HP:0010459)3.04055719
30Calf muscle hypertrophy (HP:0008981)2.94894923
31Lipid accumulation in hepatocytes (HP:0006561)2.91663932
32Bronchitis (HP:0012387)2.88040903
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.87080039
34Increased hepatocellular lipid droplets (HP:0006565)2.84659508
353-Methylglutaconic aciduria (HP:0003535)2.84585539
36Muscle hypertrophy of the lower extremities (HP:0008968)2.83611698
37Abnormality of the nasal mucosa (HP:0000433)2.83105232
38Pachygyria (HP:0001302)2.78738863
39Bronchiectasis (HP:0002110)2.73210709
40Exercise-induced muscle cramps (HP:0003710)2.71210843
41Abnormal rod and cone electroretinograms (HP:0008323)2.60841472
42Renal cortical cysts (HP:0000803)2.58282104
43Lactic acidosis (HP:0003128)2.57305335
44Increased serum lactate (HP:0002151)2.55102462
45Type II lissencephaly (HP:0007260)2.54031220
46Abnormality of the lower motor neuron (HP:0002366)2.53004884
47Lissencephaly (HP:0001339)2.52960684
48Medial flaring of the eyebrow (HP:0010747)2.48739301
49Aplasia/Hypoplasia of the brainstem (HP:0007362)2.40628276
50Hypoplasia of the brainstem (HP:0002365)2.40628276
51Genital tract atresia (HP:0001827)2.39273824
52Vaginal atresia (HP:0000148)2.38992577
53Tubulointerstitial nephritis (HP:0001970)2.35808232
54Respiratory failure (HP:0002878)2.34956783
55Bundle branch block (HP:0011710)2.34547045
56Abnormality of the renal medulla (HP:0100957)2.33601517
57Cerebral edema (HP:0002181)2.33481318
58Renal Fanconi syndrome (HP:0001994)2.33162660
59Myoglobinuria (HP:0002913)2.31461564
60Male infertility (HP:0003251)2.30664484
61Abnormality of the renal cortex (HP:0011035)2.29361437
62Gait imbalance (HP:0002141)2.28350191
63Poor coordination (HP:0002370)2.27059161
64Sclerocornea (HP:0000647)2.26285473
65Hyperglycinemia (HP:0002154)2.25766105
66Postaxial foot polydactyly (HP:0001830)2.22143066
67Optic disc pallor (HP:0000543)2.18933929
68Atonic seizures (HP:0010819)2.18409044
69Central scotoma (HP:0000603)2.17897549
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.17784194
71Abnormality of the anterior horn cell (HP:0006802)2.16608025
72Degeneration of anterior horn cells (HP:0002398)2.16608025
73Hyperalaninemia (HP:0003348)2.16282128
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16282128
75Abnormality of alanine metabolism (HP:0010916)2.16282128
76Cerebellar dysplasia (HP:0007033)2.16043163
77Occipital encephalocele (HP:0002085)2.14815544
78Exercise intolerance (HP:0003546)2.12590325
79Increased serum pyruvate (HP:0003542)2.09739722
80Increased intramyocellular lipid droplets (HP:0012240)2.08638911
81Unsteady gait (HP:0002317)2.07681167
82Sudden death (HP:0001699)2.06845089
83Decreased central vision (HP:0007663)2.01628381
84Congenital stationary night blindness (HP:0007642)2.01137340
85Visual hallucinations (HP:0002367)2.01136456
86Abnormality of the labia minora (HP:0012880)2.00793985
87Optic nerve hypoplasia (HP:0000609)2.00716435
88Cerebral hypomyelination (HP:0006808)1.98942399
89Type I transferrin isoform profile (HP:0003642)1.98534933
90Asymmetric septal hypertrophy (HP:0001670)1.97893126
91Abnormality of glycolysis (HP:0004366)1.97856269
92Inappropriate behavior (HP:0000719)1.97831792
93Difficulty running (HP:0009046)1.96886688
94Dicarboxylic aciduria (HP:0003215)1.96283319
95Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96283319
96Colon cancer (HP:0003003)1.95473577
97Chronic hepatic failure (HP:0100626)1.94668304
98Specific learning disability (HP:0001328)1.94114847
99Disinhibition (HP:0000734)1.93806949
100Atrophy/Degeneration involving motor neurons (HP:0007373)1.92752549
101Abnormality of the calf musculature (HP:0001430)1.92165473
102Attenuation of retinal blood vessels (HP:0007843)1.89811422
103Dyschromatopsia (HP:0007641)1.89251753
104Poor suck (HP:0002033)1.88926124
105Emotional lability (HP:0000712)1.87390125
106Progressive inability to walk (HP:0002505)1.87075409
107Large eyes (HP:0001090)1.86687338
108Short tibia (HP:0005736)1.86653519
109Progressive microcephaly (HP:0000253)1.85627244
110Increased muscle lipid content (HP:0009058)1.85325145
111Cystic liver disease (HP:0006706)1.83036841
112Anencephaly (HP:0002323)1.82571566
113Broad foot (HP:0001769)1.82134204
114Abnormality of the left ventricular outflow tract (HP:0011103)1.81814873
115Subaortic stenosis (HP:0001682)1.81814873
116Polyphagia (HP:0002591)1.81464891
117Cortical dysplasia (HP:0002539)1.80947564
118Renal duplication (HP:0000075)1.80054536
119Retinal dysplasia (HP:0007973)1.79985947
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.79802749
121Papillary thyroid carcinoma (HP:0002895)1.79377910
122CNS demyelination (HP:0007305)1.78388150
123Hyperacusis (HP:0010780)1.77412588
124Shoulder girdle muscle weakness (HP:0003547)1.76920024
125Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76327891
126Leukodystrophy (HP:0002415)1.76140794
127Neuroendocrine neoplasm (HP:0100634)1.75664194
128Recurrent otitis media (HP:0000403)1.75586675
129Hyperglycinuria (HP:0003108)1.75352207
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74840049
131Abnormal protein N-linked glycosylation (HP:0012347)1.74840049
132Abnormal protein glycosylation (HP:0012346)1.74840049
133Abnormal glycosylation (HP:0012345)1.74840049
134CNS hypomyelination (HP:0003429)1.74755130
135Type 2 muscle fiber atrophy (HP:0003554)1.74283416
136Gonadotropin excess (HP:0000837)1.71270814
137Bell-shaped thorax (HP:0001591)1.68928806
138Abnormality of midbrain morphology (HP:0002418)1.68455657
139Molar tooth sign on MRI (HP:0002419)1.68455657
140Mutism (HP:0002300)1.68166056
141Megalencephaly (HP:0001355)1.67952766
142Papilledema (HP:0001085)1.67365839
143Elfin facies (HP:0004428)1.67044699
144Delayed gross motor development (HP:0002194)1.65948900
145Poor eye contact (HP:0000817)1.65802235
146Genetic anticipation (HP:0003743)1.64033225
147Ulnar deviation of the wrist (HP:0003049)1.63892673
148Rimmed vacuoles (HP:0003805)1.63822767
149Postaxial hand polydactyly (HP:0001162)1.62061857
150Constricted visual fields (HP:0001133)1.61007881
151Congenital primary aphakia (HP:0007707)1.60738117
152Muscle fiber inclusion bodies (HP:0100299)1.60600146
153Myotonia (HP:0002486)1.59868787
154Left ventricular hypertrophy (HP:0001712)1.59229775
155Tubulointerstitial abnormality (HP:0001969)1.58488867
156Hypoplasia of the pons (HP:0012110)1.56762555
157Renovascular hypertension (HP:0100817)1.55574081
158Pheochromocytoma (HP:0002666)1.54519958
159Polymicrogyria (HP:0002126)1.54474981
160Hyporeflexia of lower limbs (HP:0002600)1.54244037
161Recurrent bronchitis (HP:0002837)1.52983548
162Ankle clonus (HP:0011448)1.52953312
163Acute necrotizing encephalopathy (HP:0006965)1.52021190
164Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.50044732
165Overriding aorta (HP:0002623)1.49425800
166Abnormal mitochondria in muscle tissue (HP:0008316)1.47798532
167Neoplasm of the peripheral nervous system (HP:0100007)1.47509785
168Recurrent sinusitis (HP:0011108)1.45853038
169Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.45142219
170Epileptic encephalopathy (HP:0200134)1.45040302
171Intellectual disability, profound (HP:0002187)1.43414225
172Inability to walk (HP:0002540)1.43254169
173Neoplasm of the adrenal gland (HP:0100631)1.41805305
174Primary atrial arrhythmia (HP:0001692)1.41079386
175Heterotopia (HP:0002282)1.40510119
176Agitation (HP:0000713)1.40355637
177Progressive cerebellar ataxia (HP:0002073)1.40204643
178Excessive salivation (HP:0003781)1.39947981
179Drooling (HP:0002307)1.39947981
180Oculomotor apraxia (HP:0000657)1.39933062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.63140303
2PDK36.63140303
3MARK15.35093236
4PDK23.73842677
5PRKD33.61998437
6TESK13.57987510
7MAP4K23.09484194
8VRK22.72316404
9MST42.72248324
10PHKG12.65844802
11PHKG22.65844802
12EIF2AK12.50668374
13TRIM282.43217760
14BCR2.26570558
15FRK2.22213202
16ZAK2.12760554
17WNK42.03329108
18STK161.96136184
19DYRK21.84402905
20EIF2AK31.79144919
21CASK1.77272614
22PASK1.74116560
23ERBB31.70171754
24BUB11.69817366
25NUAK11.66566407
26CDK191.61527111
27GRK11.59648464
28STK381.43839426
29OBSCN1.42698582
30BCKDK1.42284096
31MINK11.40912451
32MAP3K41.40333436
33MAP2K71.37967345
34ICK1.36297869
35CSNK1G11.36066630
36VRK11.33964990
37TSSK61.32008944
38PRKCI1.24112667
39MAPK131.23828793
40ADRBK21.22726205
41MAP2K61.17168887
42CCNB11.15767818
43NEK11.13876530
44CDK81.12874648
45SIK21.11107183
46PNCK1.09583695
47CAMKK11.08829152
48STK391.08642234
49PTK2B1.07176317
50SIK31.07136517
51PLK41.06647071
52TRIB31.05670447
53NTRK21.03870910
54LMTK21.00990788
55NTRK30.99252158
56PLK10.97914657
57PLK20.95871734
58ILK0.95703287
59DYRK1B0.95556887
60MAP3K120.94541630
61TESK20.93657282
62ARAF0.90997727
63LATS20.89782887
64BMPR1B0.88520794
65LIMK10.86122167
66WEE10.84715893
67EPHA40.84601614
68NME10.80499488
69TAOK10.79049990
70PRKCE0.78757280
71SCYL20.78534568
72TTK0.76222011
73EIF2AK20.75816355
74MAPKAPK50.73316790
75TTN0.70434815
76MAP2K40.70137274
77CAMKK20.68265321
78PKN20.67474703
79MAP3K90.67211789
80STK240.65720670
81STK38L0.65271026
82PINK10.64602937
83TLK10.64548254
84FGFR20.64127579
85CDC70.62688310
86MAP3K60.60433477
87RPS6KA20.59836078
88EEF2K0.59464699
89MUSK0.57909868
90PIM20.57357425
91DAPK20.57129181
92AURKA0.56228803
93FER0.54524861
94CSNK1G20.54016372
95NEK20.53108341
96GRK50.51752513
97PDK10.49933301
98TAOK30.49405417
99MARK20.49201740
100CDK50.49084933
101PRKCG0.48073825
102MAPKAPK30.47652432
103EPHB20.45975003
104OXSR10.44647717
105PRKAA10.44542244
106PBK0.42967607
107MAP3K50.42718219
108PRKCZ0.42691390
109UHMK10.42405375
110CAMK2G0.42027767
111DYRK30.41641343
112CAMK2B0.40982962
113CDK140.40635970
114CAMK2D0.39861150
115ERBB40.39475157
116PKN10.38944445
117CSNK1A10.38861189
118TGFBR10.38852495
119DAPK10.38279865
120PIK3CA0.38227609
121BRSK10.38035267
122CSNK1E0.37299928
123DYRK1A0.37070467
124PRKACB0.37015941
125PAK60.35581742
126CAMK1G0.32924109
127CHEK20.32716906
128WNK10.32542181
129CDK150.32019922
130RPS6KB10.31959588
131CDK11A0.30245567
132CDK180.30099749
133DMPK0.29999814
134KSR10.27556842
135WNK30.25965624
136CHEK10.24235320
137PAK30.23908529
138CSNK1G30.22270992
139PLK30.21925502
140CAMK10.21488198
141CSNK1A1L0.21484233
142RET0.19243145
143SRPK10.18693107
144ATR0.17854058
145NEK90.17786551
146PRKDC0.17064693
147CAMK2A0.16668320
148CSNK1D0.15950333
149PRKG10.15866585
150CDC42BPA0.15058134
151PRKCH0.15023202
152ADRBK10.14661620
153MAPK120.11607196

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.98096631
2RNA polymerase_Homo sapiens_hsa030202.35496405
3Cardiac muscle contraction_Homo sapiens_hsa042602.30817737
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25843859
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18254162
6Huntingtons disease_Homo sapiens_hsa050162.11747450
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93043192
8Oocyte meiosis_Homo sapiens_hsa041141.92304170
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.91373069
10Glucagon signaling pathway_Homo sapiens_hsa049221.84922122
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80693183
12RNA degradation_Homo sapiens_hsa030181.80179623
13Homologous recombination_Homo sapiens_hsa034401.77204110
14Parkinsons disease_Homo sapiens_hsa050121.76407437
15Amphetamine addiction_Homo sapiens_hsa050311.75812020
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73603362
17Protein export_Homo sapiens_hsa030601.72750689
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.72128134
19Circadian entrainment_Homo sapiens_hsa047131.71658409
20Olfactory transduction_Homo sapiens_hsa047401.67903989
21Long-term potentiation_Homo sapiens_hsa047201.67145047
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.66598376
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57603120
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55778161
25Non-homologous end-joining_Homo sapiens_hsa034501.55581971
26Pyruvate metabolism_Homo sapiens_hsa006201.54110407
27Insulin secretion_Homo sapiens_hsa049111.53294783
28Fatty acid elongation_Homo sapiens_hsa000621.53189676
29Nucleotide excision repair_Homo sapiens_hsa034201.51979700
30Mismatch repair_Homo sapiens_hsa034301.51657115
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51557453
32Alzheimers disease_Homo sapiens_hsa050101.50348753
33Renin secretion_Homo sapiens_hsa049241.50042836
34Dopaminergic synapse_Homo sapiens_hsa047281.49691503
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.42298091
36Oxidative phosphorylation_Homo sapiens_hsa001901.40028470
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38991805
38Basal transcription factors_Homo sapiens_hsa030221.38211658
39Synaptic vesicle cycle_Homo sapiens_hsa047211.36765895
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33856364
41One carbon pool by folate_Homo sapiens_hsa006701.30855909
42Base excision repair_Homo sapiens_hsa034101.30501170
43mRNA surveillance pathway_Homo sapiens_hsa030151.28875678
44Phototransduction_Homo sapiens_hsa047441.27266385
45Propanoate metabolism_Homo sapiens_hsa006401.25355186
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24204898
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22379072
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.21361229
49Morphine addiction_Homo sapiens_hsa050321.18673118
50Cholinergic synapse_Homo sapiens_hsa047251.16454982
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14094836
52Peroxisome_Homo sapiens_hsa041461.12795050
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11580054
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10557503
55Cocaine addiction_Homo sapiens_hsa050301.09888073
56Calcium signaling pathway_Homo sapiens_hsa040201.09714545
57Glutamatergic synapse_Homo sapiens_hsa047241.09076140
58Axon guidance_Homo sapiens_hsa043601.08748082
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.08576345
60SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07271064
61Oxytocin signaling pathway_Homo sapiens_hsa049211.06683794
62Circadian rhythm_Homo sapiens_hsa047101.04631479
63N-Glycan biosynthesis_Homo sapiens_hsa005101.04060854
64Glutathione metabolism_Homo sapiens_hsa004801.03241486
65Taste transduction_Homo sapiens_hsa047421.02453796
66Dilated cardiomyopathy_Homo sapiens_hsa054141.02431530
67beta-Alanine metabolism_Homo sapiens_hsa004101.02263667
68Collecting duct acid secretion_Homo sapiens_hsa049661.02179732
69Butanoate metabolism_Homo sapiens_hsa006501.01300946
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99631163
71Folate biosynthesis_Homo sapiens_hsa007900.98208109
72RNA transport_Homo sapiens_hsa030130.97830271
73Purine metabolism_Homo sapiens_hsa002300.97781458
74Estrogen signaling pathway_Homo sapiens_hsa049150.97068159
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95175079
76Endometrial cancer_Homo sapiens_hsa052130.92327322
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92163618
78Type II diabetes mellitus_Homo sapiens_hsa049300.90756920
79Insulin signaling pathway_Homo sapiens_hsa049100.90656949
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89438045
81GABAergic synapse_Homo sapiens_hsa047270.89248214
82Regulation of autophagy_Homo sapiens_hsa041400.88584662
83Vibrio cholerae infection_Homo sapiens_hsa051100.88498364
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88315588
85Viral myocarditis_Homo sapiens_hsa054160.88153798
86Proteasome_Homo sapiens_hsa030500.86657842
87Steroid biosynthesis_Homo sapiens_hsa001000.85698441
88Gastric acid secretion_Homo sapiens_hsa049710.84972204
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84881924
90DNA replication_Homo sapiens_hsa030300.84763945
91Dorso-ventral axis formation_Homo sapiens_hsa043200.84691074
92Nitrogen metabolism_Homo sapiens_hsa009100.84647448
93Metabolic pathways_Homo sapiens_hsa011000.84470119
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84406032
95Vitamin B6 metabolism_Homo sapiens_hsa007500.82630817
96AMPK signaling pathway_Homo sapiens_hsa041520.82602738
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.81778447
98VEGF signaling pathway_Homo sapiens_hsa043700.81188838
99Gap junction_Homo sapiens_hsa045400.80939507
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79476030
101Arginine and proline metabolism_Homo sapiens_hsa003300.77381245
102Alcoholism_Homo sapiens_hsa050340.75680795
103Colorectal cancer_Homo sapiens_hsa052100.72592199
104Nicotine addiction_Homo sapiens_hsa050330.70177786
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67974426
106Selenocompound metabolism_Homo sapiens_hsa004500.67650636
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67110040
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66999248
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65598737
110Melanogenesis_Homo sapiens_hsa049160.65410652
111Wnt signaling pathway_Homo sapiens_hsa043100.65297272
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64841986
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64756952
114cAMP signaling pathway_Homo sapiens_hsa040240.64653006
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.62258801
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62172355
117mTOR signaling pathway_Homo sapiens_hsa041500.61982415
118Glioma_Homo sapiens_hsa052140.61694364
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61440650
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59026154
121Carbon metabolism_Homo sapiens_hsa012000.58632114
122Linoleic acid metabolism_Homo sapiens_hsa005910.58513579
123Fatty acid biosynthesis_Homo sapiens_hsa000610.58244677
124MAPK signaling pathway_Homo sapiens_hsa040100.57872021
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.57776185
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.57388023
127Spliceosome_Homo sapiens_hsa030400.54782202
128Fanconi anemia pathway_Homo sapiens_hsa034600.54514629
129Ether lipid metabolism_Homo sapiens_hsa005650.54416981
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54287823
131Endocytosis_Homo sapiens_hsa041440.54123210
132Biosynthesis of amino acids_Homo sapiens_hsa012300.53739608
133Serotonergic synapse_Homo sapiens_hsa047260.51590135
134Fatty acid metabolism_Homo sapiens_hsa012120.49928980
135Hedgehog signaling pathway_Homo sapiens_hsa043400.49284175
136Pyrimidine metabolism_Homo sapiens_hsa002400.48977180
137Cell cycle_Homo sapiens_hsa041100.48727659
138Ribosome_Homo sapiens_hsa030100.47658400
139Insulin resistance_Homo sapiens_hsa049310.46045811
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45264459
141Salivary secretion_Homo sapiens_hsa049700.44178292
142Thyroid hormone synthesis_Homo sapiens_hsa049180.40934593
143ErbB signaling pathway_Homo sapiens_hsa040120.40521234
144Renal cell carcinoma_Homo sapiens_hsa052110.40480081
145Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40107081
146GnRH signaling pathway_Homo sapiens_hsa049120.39431432
147Long-term depression_Homo sapiens_hsa047300.38728571
148Epstein-Barr virus infection_Homo sapiens_hsa051690.38393055
149Phenylalanine metabolism_Homo sapiens_hsa003600.37319029
150p53 signaling pathway_Homo sapiens_hsa041150.37204567
151Fatty acid degradation_Homo sapiens_hsa000710.34104720
152Primary bile acid biosynthesis_Homo sapiens_hsa001200.32118388
153Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31456087
154Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27645472
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26015631
156Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25633854
157Cyanoamino acid metabolism_Homo sapiens_hsa004600.24380507

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