AMZ2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.45685419
2intraciliary transport (GO:0042073)4.35185241
3protein complex biogenesis (GO:0070271)4.21432438
4respiratory chain complex IV assembly (GO:0008535)4.02547037
5regulation of cilium movement (GO:0003352)3.99983542
6mitochondrial respiratory chain complex I assembly (GO:0032981)3.99320976
7NADH dehydrogenase complex assembly (GO:0010257)3.99320976
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99320976
9mitochondrial respiratory chain complex assembly (GO:0033108)3.85507589
10cullin deneddylation (GO:0010388)3.84510054
11water-soluble vitamin biosynthetic process (GO:0042364)3.77703896
12nonmotile primary cilium assembly (GO:0035058)3.72619164
13cytochrome complex assembly (GO:0017004)3.62742392
14platelet dense granule organization (GO:0060155)3.60648733
15protein localization to cilium (GO:0061512)3.55335205
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.47319734
17positive regulation of mitochondrial fission (GO:0090141)3.43356011
18protein deneddylation (GO:0000338)3.42953387
19DNA double-strand break processing (GO:0000729)3.40017203
20protein-cofactor linkage (GO:0018065)3.34353516
21proteasome assembly (GO:0043248)3.23120370
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.23079677
23gamma-aminobutyric acid transport (GO:0015812)3.18304659
24epithelial cilium movement (GO:0003351)3.14618773
25L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.11441861
26pyrimidine nucleobase catabolic process (GO:0006208)3.10186764
27presynaptic membrane assembly (GO:0097105)3.05603080
28protein neddylation (GO:0045116)3.04960809
29preassembly of GPI anchor in ER membrane (GO:0016254)3.03127100
30neuronal action potential propagation (GO:0019227)3.02844681
31seminiferous tubule development (GO:0072520)3.00798734
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99638599
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99638599
34mannosylation (GO:0097502)2.98683093
35cilium organization (GO:0044782)2.98297710
36anterograde synaptic vesicle transport (GO:0048490)2.97988468
37cilium assembly (GO:0042384)2.96340283
38negative regulation of heart rate (GO:0010459)2.90233349
39energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89756402
40ATP synthesis coupled proton transport (GO:0015986)2.89756402
41GPI anchor metabolic process (GO:0006505)2.88845289
42pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87774114
43presynaptic membrane organization (GO:0097090)2.87172366
44negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87172323
45acrosome reaction (GO:0007340)2.81724163
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81299418
47respiratory electron transport chain (GO:0022904)2.80900835
48electron transport chain (GO:0022900)2.78781680
49axoneme assembly (GO:0035082)2.76538397
50cilium morphogenesis (GO:0060271)2.75486899
51protein polyglutamylation (GO:0018095)2.72528977
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71584177
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70759806
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70512599
55C4-dicarboxylate transport (GO:0015740)2.67876958
56aldehyde catabolic process (GO:0046185)2.66912726
57chaperone-mediated protein transport (GO:0072321)2.66766313
58glycosphingolipid biosynthetic process (GO:0006688)2.65766845
59neuron cell-cell adhesion (GO:0007158)2.64546424
60iron-sulfur cluster assembly (GO:0016226)2.64449273
61metallo-sulfur cluster assembly (GO:0031163)2.64449273
62transmission of nerve impulse (GO:0019226)2.64262031
63retinal rod cell development (GO:0046548)2.61932647
64C-terminal protein lipidation (GO:0006501)2.60824881
65positive regulation of amino acid transport (GO:0051957)2.59191700
66cilium movement (GO:0003341)2.58375563
67ubiquinone biosynthetic process (GO:0006744)2.58137678
68branched-chain amino acid catabolic process (GO:0009083)2.56247837
69amino acid salvage (GO:0043102)2.55715274
70L-methionine salvage (GO:0071267)2.55715274
71L-methionine biosynthetic process (GO:0071265)2.55715274
72DNA deamination (GO:0045006)2.55364558
73dopamine transport (GO:0015872)2.54226826
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54172637
75ubiquinone metabolic process (GO:0006743)2.53926994
76postsynaptic membrane organization (GO:0001941)2.52893798
77retinal cone cell development (GO:0046549)2.51740247
78nucleobase catabolic process (GO:0046113)2.50258857
79energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.49773469
80ATP hydrolysis coupled proton transport (GO:0015991)2.49773469
81sperm motility (GO:0030317)2.48506446
82GPI anchor biosynthetic process (GO:0006506)2.48401029
83regulation of microtubule-based movement (GO:0060632)2.45265381
84negative regulation of telomere maintenance (GO:0032205)2.44835073
85neural tube formation (GO:0001841)2.44725872
86anterograde axon cargo transport (GO:0008089)2.44538998
87glycolipid biosynthetic process (GO:0009247)2.44239719
88C-terminal protein amino acid modification (GO:0018410)2.43208054
89negative regulation of appetite (GO:0032099)2.42860891
90negative regulation of response to food (GO:0032096)2.42860891
91synaptic vesicle exocytosis (GO:0016079)2.41668795
92base-excision repair, AP site formation (GO:0006285)2.41123244
93photoreceptor cell maintenance (GO:0045494)2.40957404
94negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.40527918
95prenylation (GO:0097354)2.39800514
96protein prenylation (GO:0018342)2.39800514
97intracellular protein transmembrane import (GO:0044743)2.39018063
98negative regulation of membrane potential (GO:0045837)2.38646854
99pyrimidine nucleotide catabolic process (GO:0006244)2.38190597
100DNA integration (GO:0015074)2.36013449

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.49314187
2GBX2_23144817_ChIP-Seq_PC3_Human3.14328274
3IGF1R_20145208_ChIP-Seq_DFB_Human3.03314446
4ZNF274_21170338_ChIP-Seq_K562_Hela3.00380266
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.84856353
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74341413
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71784897
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68475948
9EZH2_22144423_ChIP-Seq_EOC_Human2.64271469
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60259108
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.47951600
12TAF15_26573619_Chip-Seq_HEK293_Human2.42508308
13VDR_22108803_ChIP-Seq_LS180_Human2.40926102
14FUS_26573619_Chip-Seq_HEK293_Human2.22846986
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14925073
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13428104
17EWS_26573619_Chip-Seq_HEK293_Human2.06590667
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04752475
19P300_19829295_ChIP-Seq_ESCs_Human2.00225570
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98567040
21ELK1_19687146_ChIP-ChIP_HELA_Human1.89068177
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.88593583
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79510801
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78839179
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75650679
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75352056
27VDR_23849224_ChIP-Seq_CD4+_Human1.74130784
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66969019
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62274704
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62244962
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60627100
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.58477645
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57768539
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54833482
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53166810
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51698378
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50841387
38CBP_20019798_ChIP-Seq_JUKART_Human1.50841387
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50448739
40ER_23166858_ChIP-Seq_MCF-7_Human1.49205596
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49104276
42* TP53_22573176_ChIP-Seq_HFKS_Human1.46073553
43SMAD4_21799915_ChIP-Seq_A2780_Human1.45617945
44MYC_18940864_ChIP-ChIP_HL60_Human1.45457642
45IRF1_19129219_ChIP-ChIP_H3396_Human1.44967140
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.39554340
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38911444
48RNF2_27304074_Chip-Seq_NSC_Mouse1.37139565
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35640599
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31913116
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31731950
52* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27547679
53AR_25329375_ChIP-Seq_VCAP_Human1.25892063
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25870379
55REST_21632747_ChIP-Seq_MESCs_Mouse1.23715078
56FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22499554
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22287790
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21693716
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.21661418
60SOX2_19829295_ChIP-Seq_ESCs_Human1.21568291
61NANOG_19829295_ChIP-Seq_ESCs_Human1.21568291
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.21073002
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20751547
64BCAT_22108803_ChIP-Seq_LS180_Human1.20152620
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19974567
66FOXP3_21729870_ChIP-Seq_TREG_Human1.18978015
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.18454496
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.18081245
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15724999
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.15533931
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14050785
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12598428
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12263782
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12218967
75STAT3_23295773_ChIP-Seq_U87_Human1.12075955
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12044597
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11789852
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11378022
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10455567
80RUNX2_22187159_ChIP-Seq_PCA_Human1.10386366
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10125521
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09544835
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.09347634
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09197530
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09164564
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09164564
87P53_22387025_ChIP-Seq_ESCs_Mouse1.08874653
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.07984961
89TCF4_23295773_ChIP-Seq_U87_Human1.07944457
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.06998414
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.06744410
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.04468467
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.03329855
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02729068
95HTT_18923047_ChIP-ChIP_STHdh_Human1.01643510
96TCF4_22108803_ChIP-Seq_LS180_Human1.01210661
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00071174
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.00071174
99JUN_21703547_ChIP-Seq_K562_Human0.98540807
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96984128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.90924967
2MP0002102_abnormal_ear_morphology2.77697331
3MP0001984_abnormal_olfaction2.70138863
4MP0000372_irregular_coat_pigmentation2.61133354
5MP0009046_muscle_twitch2.48682422
6MP0001529_abnormal_vocalization2.33939060
7MP0008877_abnormal_DNA_methylation2.32532721
8MP0004859_abnormal_synaptic_plasticity2.23059120
9MP0006276_abnormal_autonomic_nervous2.22590311
10MP0001968_abnormal_touch/_nociception2.21010361
11MP0002653_abnormal_ependyma_morphology2.18772748
12MP0002736_abnormal_nociception_after2.12007478
13MP0008789_abnormal_olfactory_epithelium2.08518445
14MP0003136_yellow_coat_color2.06692938
15MP0002272_abnormal_nervous_system2.05812235
16MP0004147_increased_porphyrin_level1.98938510
17MP0001486_abnormal_startle_reflex1.97169993
18MP0009745_abnormal_behavioral_response1.95788343
19MP0005551_abnormal_eye_electrophysiolog1.92500386
20MP0002638_abnormal_pupillary_reflex1.91778798
21MP0003787_abnormal_imprinting1.91255815
22MP0003122_maternal_imprinting1.89339397
23MP0006072_abnormal_retinal_apoptosis1.82447098
24MP0005253_abnormal_eye_physiology1.79285539
25MP0003011_delayed_dark_adaptation1.79174563
26MP0006292_abnormal_olfactory_placode1.76140260
27MP0005394_taste/olfaction_phenotype1.75957458
28MP0005499_abnormal_olfactory_system1.75957458
29MP0005646_abnormal_pituitary_gland1.74100456
30MP0004142_abnormal_muscle_tone1.74062024
31MP0005171_absent_coat_pigmentation1.71020190
32MP0003635_abnormal_synaptic_transmissio1.68862994
33MP0002064_seizures1.67676648
34MP0002735_abnormal_chemical_nociception1.63808813
35MP0005645_abnormal_hypothalamus_physiol1.59242837
36MP0002572_abnormal_emotion/affect_behav1.58959894
37MP0004270_analgesia1.54270911
38MP0001986_abnormal_taste_sensitivity1.52782855
39MP0002822_catalepsy1.51836347
40MP0003121_genomic_imprinting1.43226128
41MP0006036_abnormal_mitochondrial_physio1.42592657
42MP0002938_white_spotting1.42296280
43MP0002090_abnormal_vision1.40637137
44MP0008058_abnormal_DNA_repair1.40446721
45MP0002734_abnormal_mechanical_nocicepti1.39503052
46MP0005423_abnormal_somatic_nervous1.39135870
47MP0005367_renal/urinary_system_phenotyp1.38960863
48MP0000516_abnormal_urinary_system1.38960863
49MP0004885_abnormal_endolymph1.38253160
50MP0002063_abnormal_learning/memory/cond1.34054572
51MP0010386_abnormal_urinary_bladder1.33760799
52MP0002067_abnormal_sensory_capabilities1.32234327
53MP0001970_abnormal_pain_threshold1.30454458
54MP0002557_abnormal_social/conspecific_i1.29515540
55MP0001485_abnormal_pinna_reflex1.26545290
56MP0001905_abnormal_dopamine_level1.25620595
57MP0005075_abnormal_melanosome_morpholog1.25411860
58MP0002095_abnormal_skin_pigmentation1.23034208
59MP0000569_abnormal_digit_pigmentation1.22528603
60MP0002234_abnormal_pharynx_morphology1.21258787
61MP0005174_abnormal_tail_pigmentation1.19759124
62MP0000778_abnormal_nervous_system1.19441540
63MP0002837_dystrophic_cardiac_calcinosis1.17503111
64MP0001501_abnormal_sleep_pattern1.17184952
65MP0000631_abnormal_neuroendocrine_gland1.15922955
66MP0004742_abnormal_vestibular_system1.09343484
67MP0001963_abnormal_hearing_physiology1.08819086
68MP0002751_abnormal_autonomic_nervous1.08619133
69MP0005410_abnormal_fertilization1.08008966
70MP0002229_neurodegeneration1.07388339
71MP0005084_abnormal_gallbladder_morpholo1.07122233
72MP0004924_abnormal_behavior1.06904252
73MP0005386_behavior/neurological_phenoty1.06904252
74MP0003186_abnormal_redox_activity1.04690004
75MP0003195_calcinosis1.02385881
76MP0006035_abnormal_mitochondrial_morpho1.01251460
77MP0008872_abnormal_physiological_respon0.99147446
78MP0001764_abnormal_homeostasis0.98440524
79MP0000026_abnormal_inner_ear0.95787095
80MP0000049_abnormal_middle_ear0.95151074
81MP0003698_abnormal_male_reproductive0.95086802
82MP0004133_heterotaxia0.94433092
83MP0001324_abnormal_eye_pigmentation0.92506902
84MP0005248_abnormal_Harderian_gland0.92194936
85MP0002882_abnormal_neuron_morphology0.91622050
86MP0008995_early_reproductive_senescence0.91314848
87MP0002733_abnormal_thermal_nociception0.90774099
88MP0002752_abnormal_somatic_nervous0.89911494
89MP0003137_abnormal_impulse_conducting0.89653454
90MP0000955_abnormal_spinal_cord0.86851710
91MP0002184_abnormal_innervation0.86261323
92MP0001929_abnormal_gametogenesis0.85462412
93MP0002876_abnormal_thyroid_physiology0.83853514
94MP0003633_abnormal_nervous_system0.79934296
95MP0002069_abnormal_eating/drinking_beha0.78056072
96MP0002066_abnormal_motor_capabilities/c0.76616496
97MP0004811_abnormal_neuron_physiology0.76451805
98MP0001440_abnormal_grooming_behavior0.75964803
99MP0002233_abnormal_nose_morphology0.75554732
100MP0003718_maternal_effect0.74848091

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)4.10103198
2Gait imbalance (HP:0002141)3.66545713
3Acute necrotizing encephalopathy (HP:0006965)3.64920831
4Congenital primary aphakia (HP:0007707)3.59731319
53-Methylglutaconic aciduria (HP:0003535)3.56652069
6Mitochondrial inheritance (HP:0001427)3.46207767
7Nephrogenic diabetes insipidus (HP:0009806)3.39326574
8Abnormality of midbrain morphology (HP:0002418)3.29411454
9Molar tooth sign on MRI (HP:0002419)3.29411454
10Abnormal mitochondria in muscle tissue (HP:0008316)3.28617158
11Progressive macrocephaly (HP:0004481)3.28084022
12Hepatocellular necrosis (HP:0001404)3.24974401
13Acute encephalopathy (HP:0006846)3.24916654
14Methylmalonic acidemia (HP:0002912)3.22564461
15Focal motor seizures (HP:0011153)3.19204338
16Hepatic necrosis (HP:0002605)3.18400146
17True hermaphroditism (HP:0010459)3.12854234
18Increased CSF lactate (HP:0002490)3.08764861
19Pancreatic cysts (HP:0001737)3.04580978
20Nephronophthisis (HP:0000090)2.97008326
21Pancreatic fibrosis (HP:0100732)2.83900679
22Genital tract atresia (HP:0001827)2.78336156
23Increased hepatocellular lipid droplets (HP:0006565)2.75343015
24Vaginal atresia (HP:0000148)2.72024377
25Lipid accumulation in hepatocytes (HP:0006561)2.65885739
26Atonic seizures (HP:0010819)2.63476296
27Hyperglycinemia (HP:0002154)2.56482398
28Methylmalonic aciduria (HP:0012120)2.53891644
29Abnormality of the labia minora (HP:0012880)2.52673691
30Renal Fanconi syndrome (HP:0001994)2.51540460
31Polyphagia (HP:0002591)2.43951936
32Retinal dysplasia (HP:0007973)2.41521104
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29341442
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29341442
35Postaxial hand polydactyly (HP:0001162)2.28633696
36Abnormality of the renal medulla (HP:0100957)2.27591502
37Cerebral edema (HP:0002181)2.24793921
38Specific learning disability (HP:0001328)2.23422269
39Tubulointerstitial nephritis (HP:0001970)2.22277664
40Poor coordination (HP:0002370)2.21674811
41Hemiparesis (HP:0001269)2.21246214
42Febrile seizures (HP:0002373)2.21084501
43Abolished electroretinogram (ERG) (HP:0000550)2.21034096
44Myokymia (HP:0002411)2.20926541
45Focal seizures (HP:0007359)2.20815023
46Lactic acidosis (HP:0003128)2.18603884
47Renal cortical cysts (HP:0000803)2.18469148
48Short tibia (HP:0005736)2.14784466
49Decreased central vision (HP:0007663)2.14016373
50Congenital stationary night blindness (HP:0007642)2.13597197
51Increased serum lactate (HP:0002151)2.12872834
52Hypothermia (HP:0002045)2.12662756
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.12332863
54Abnormality of macular pigmentation (HP:0008002)2.12282209
55Type II lissencephaly (HP:0007260)2.10789849
56Increased intramyocellular lipid droplets (HP:0012240)2.10144749
57Postaxial foot polydactyly (HP:0001830)2.07964604
58Absent speech (HP:0001344)2.04838391
59Dialeptic seizures (HP:0011146)2.02951729
60Optic disc pallor (HP:0000543)2.01346560
61Chronic hepatic failure (HP:0100626)2.00972078
62Lissencephaly (HP:0001339)1.98180517
63Progressive microcephaly (HP:0000253)1.96240501
64Respiratory failure (HP:0002878)1.93940416
65Broad foot (HP:0001769)1.92202771
66Abnormal biliary tract physiology (HP:0012439)1.91342004
67Bile duct proliferation (HP:0001408)1.91342004
68Progressive cerebellar ataxia (HP:0002073)1.90506748
69Median cleft lip (HP:0000161)1.89701410
70Decreased testicular size (HP:0008734)1.89378598
71Hyperventilation (HP:0002883)1.89356886
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.87033161
73Aplasia/Hypoplasia of the lens (HP:0008063)1.84649717
74CNS demyelination (HP:0007305)1.84428322
75Lethargy (HP:0001254)1.82763976
76Abnormality of glycine metabolism (HP:0010895)1.82186253
77Abnormality of serine family amino acid metabolism (HP:0010894)1.82186253
78Abnormality of the renal cortex (HP:0011035)1.82027137
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81896728
80Dicarboxylic aciduria (HP:0003215)1.81896728
81Progressive inability to walk (HP:0002505)1.81384242
82Abnormal respiratory epithelium morphology (HP:0012253)1.81054088
83Abnormal respiratory motile cilium morphology (HP:0005938)1.81054088
84Limb dystonia (HP:0002451)1.78838471
85Congenital hepatic fibrosis (HP:0002612)1.78810056
86Inability to walk (HP:0002540)1.77903067
87Broad-based gait (HP:0002136)1.76942489
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76643280
89Emotional lability (HP:0000712)1.76131616
90Type I transferrin isoform profile (HP:0003642)1.75534849
91Absence seizures (HP:0002121)1.74336460
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74202317
93Optic nerve hypoplasia (HP:0000609)1.74140632
94Large for gestational age (HP:0001520)1.73918387
95Increased muscle lipid content (HP:0009058)1.73325687
96Cystic liver disease (HP:0006706)1.73225457
97Abnormality of vitamin B metabolism (HP:0004340)1.72653412
98Aganglionic megacolon (HP:0002251)1.72463546
99Abnormality of the vitamin B12 metabolism (HP:0004341)1.71518791
100Exercise intolerance (HP:0003546)1.71434594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.59200076
2MAP3K42.94994412
3WNK32.73753903
4FRK2.54051978
5MAP2K72.50111687
6BCKDK2.32495830
7TRIM282.30968926
8MAPK132.29873547
9MARK12.09931059
10BMPR1B1.96985287
11CASK1.93626733
12PLK21.89525362
13BCR1.87701649
14NUAK11.86772108
15CSNK1G21.86247806
16CSNK1G31.81381748
17PINK11.67184670
18CSNK1G11.61161951
19CCNB11.58148315
20ERBB31.58028642
21CSNK1A1L1.49732118
22ADRBK21.43575804
23MST41.43352917
24GRK11.38552328
25SRPK11.34771169
26TNIK1.33859925
27CDK191.33249185
28EPHA41.29092070
29DYRK21.25272337
30PIM21.23388139
31TAOK31.18362638
32INSRR1.17555360
33STK161.14944425
34NTRK21.14357177
35PAK31.12555388
36PRKCG1.10707551
37UHMK11.09139424
38FER1.05422726
39VRK11.01759717
40PRKCE1.01109169
41EIF2AK30.95102144
42PNCK0.94865851
43MINK10.90554172
44ZAK0.90053466
45FES0.89602495
46CAMKK20.89462218
47PLK30.87824489
48VRK20.86402892
49STK390.85875072
50OXSR10.85356936
51GRK50.80884455
52CAMK2A0.80111923
53PRKD30.76871274
54MKNK20.75861093
55MKNK10.75653625
56PAK60.75113193
57LIMK10.73888035
58PLK40.71352025
59PDK20.68823127
60EPHA30.68504869
61BMPR20.63780319
62MAP3K120.62048796
63PHKG20.61752236
64PHKG10.61752236
65EIF2AK10.61387805
66DAPK20.60293898
67PKN10.60229532
68MUSK0.60215019
69TXK0.58186980
70FLT30.57123480
71CSNK1A10.55399697
72CAMK2B0.55244594
73WNK40.54135630
74MAP3K50.53326966
75CAMK10.52807486
76OBSCN0.52768009
77MAP2K40.51624892
78STK38L0.51260148
79RPS6KA50.51096645
80PRKACA0.50785289
81DYRK1A0.48125171
82GRK70.48097590
83WEE10.45402224
84NME10.45254876
85PLK10.45241261
86KIT0.44582960
87PRKG10.44496077
88PRKCQ0.42955595
89CDK50.42934442
90TSSK60.42354397
91CAMK2D0.41946879
92CSNK1D0.40956387
93DAPK10.40853815
94MAPKAPK50.39674019
95RPS6KA40.39195656
96TIE10.38291989
97PRKACB0.38092873
98TLK10.37583574
99TEC0.36617297
100DYRK30.36226221

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.72712061
2Oxidative phosphorylation_Homo sapiens_hsa001903.49053869
3Parkinsons disease_Homo sapiens_hsa050122.98143667
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.82589754
5Nicotine addiction_Homo sapiens_hsa050332.74191811
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.72396453
7Propanoate metabolism_Homo sapiens_hsa006402.22326293
8Proteasome_Homo sapiens_hsa030502.09300643
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05055948
10Butanoate metabolism_Homo sapiens_hsa006501.94100951
11Fatty acid elongation_Homo sapiens_hsa000621.91201920
12Collecting duct acid secretion_Homo sapiens_hsa049661.89210691
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85697342
14Huntingtons disease_Homo sapiens_hsa050161.84913580
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84650235
16GABAergic synapse_Homo sapiens_hsa047271.83000165
17Regulation of autophagy_Homo sapiens_hsa041401.77221493
18Phototransduction_Homo sapiens_hsa047441.77217158
19Alzheimers disease_Homo sapiens_hsa050101.74792278
20Basal transcription factors_Homo sapiens_hsa030221.70628589
21Synaptic vesicle cycle_Homo sapiens_hsa047211.58299248
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58134356
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56693716
24Peroxisome_Homo sapiens_hsa041461.54563740
25Morphine addiction_Homo sapiens_hsa050321.54195148
26Homologous recombination_Homo sapiens_hsa034401.52638609
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51667561
28RNA polymerase_Homo sapiens_hsa030201.48468045
29Cardiac muscle contraction_Homo sapiens_hsa042601.47984710
30Fanconi anemia pathway_Homo sapiens_hsa034601.42074166
31Steroid biosynthesis_Homo sapiens_hsa001001.38719837
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37689695
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36058024
34RNA degradation_Homo sapiens_hsa030181.29931891
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29062613
36Nitrogen metabolism_Homo sapiens_hsa009101.21583825
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16317877
38Taste transduction_Homo sapiens_hsa047421.13816217
39Circadian entrainment_Homo sapiens_hsa047131.10952315
40Non-homologous end-joining_Homo sapiens_hsa034501.05172947
41Olfactory transduction_Homo sapiens_hsa047401.00342778
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99990428
43Glutamatergic synapse_Homo sapiens_hsa047240.98755120
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96980151
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95089442
46Base excision repair_Homo sapiens_hsa034100.94083506
47Fatty acid metabolism_Homo sapiens_hsa012120.90762348
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88411856
49Dopaminergic synapse_Homo sapiens_hsa047280.86766708
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86356408
51Circadian rhythm_Homo sapiens_hsa047100.85323015
52Linoleic acid metabolism_Homo sapiens_hsa005910.84607842
53Amphetamine addiction_Homo sapiens_hsa050310.83338177
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81615685
55Tryptophan metabolism_Homo sapiens_hsa003800.80695055
56Cocaine addiction_Homo sapiens_hsa050300.79752970
57Ether lipid metabolism_Homo sapiens_hsa005650.79531615
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79152346
59Purine metabolism_Homo sapiens_hsa002300.76800287
60Spliceosome_Homo sapiens_hsa030400.74954633
61Folate biosynthesis_Homo sapiens_hsa007900.74245190
62Metabolic pathways_Homo sapiens_hsa011000.74133806
63Selenocompound metabolism_Homo sapiens_hsa004500.72775364
64Nucleotide excision repair_Homo sapiens_hsa034200.72150783
65beta-Alanine metabolism_Homo sapiens_hsa004100.71139200
66Fatty acid degradation_Homo sapiens_hsa000710.70708603
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.70631943
68Insulin secretion_Homo sapiens_hsa049110.69697146
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.68978273
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67320620
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66195901
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.64849680
73Chemical carcinogenesis_Homo sapiens_hsa052040.62405833
74Glutathione metabolism_Homo sapiens_hsa004800.57354631
75Serotonergic synapse_Homo sapiens_hsa047260.56570442
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56500247
77RNA transport_Homo sapiens_hsa030130.55991218
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55066178
79Sulfur metabolism_Homo sapiens_hsa009200.53009748
80Oocyte meiosis_Homo sapiens_hsa041140.52707323
81Pyruvate metabolism_Homo sapiens_hsa006200.50370096
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48795240
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48428581
84Rheumatoid arthritis_Homo sapiens_hsa053230.47624286
85Pyrimidine metabolism_Homo sapiens_hsa002400.45685922
86Retinol metabolism_Homo sapiens_hsa008300.44675772
87Mismatch repair_Homo sapiens_hsa034300.43966467
88Calcium signaling pathway_Homo sapiens_hsa040200.43077071
89Arachidonic acid metabolism_Homo sapiens_hsa005900.42028488
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41860672
91Vibrio cholerae infection_Homo sapiens_hsa051100.39446332
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39163560
93Ribosome_Homo sapiens_hsa030100.39016209
94Salivary secretion_Homo sapiens_hsa049700.38479150
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36561420
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36306219
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35557244
98Carbon metabolism_Homo sapiens_hsa012000.30911297
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.28883010
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27477473

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