AMZ2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glycogen (starch) synthase activity (GO:2000465)9.73960628
2response to histamine (GO:0034776)9.27890697
3protein K11-linked deubiquitination (GO:0035871)6.69705861
4negative regulation of calcium ion-dependent exocytosis (GO:0045955)6.18525359
5vocalization behavior (GO:0071625)5.99212237
6cellular response to ammonium ion (GO:0071242)5.67824661
7neural tube formation (GO:0001841)5.50787131
8sequestering of actin monomers (GO:0042989)5.41321719
9gamma-aminobutyric acid transport (GO:0015812)5.38002584
10protein polyglutamylation (GO:0018095)5.35930660
11positive regulation of glycogen biosynthetic process (GO:0045725)5.16157830
12adult feeding behavior (GO:0008343)5.15351894
13amyloid precursor protein catabolic process (GO:0042987)4.84676393
14positive regulation of glycogen metabolic process (GO:0070875)4.63601009
15positive regulation of protein homooligomerization (GO:0032464)4.62850186
16protein K63-linked deubiquitination (GO:0070536)4.62515222
17behavioral response to nicotine (GO:0035095)4.52641679
18amino acid transmembrane transport (GO:0003333)4.32125778
19regulation of energy homeostasis (GO:2000505)4.23429045
20negative regulation of exocytosis (GO:0045920)4.19569561
21epithelial cilium movement (GO:0003351)4.04222236
22spinal cord association neuron differentiation (GO:0021527)4.04176529
23axoneme assembly (GO:0035082)4.01244315
24social behavior (GO:0035176)3.82498890
25intraspecies interaction between organisms (GO:0051703)3.82498890
26neuron cell-cell adhesion (GO:0007158)3.76346702
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.76051297
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.75818772
29adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.56020104
30regulation of autophagic vacuole assembly (GO:2000785)3.55927521
31motile cilium assembly (GO:0044458)3.54980654
32cilium movement (GO:0003341)3.53522783
33inositol phosphate dephosphorylation (GO:0046855)3.33996344
34phosphorylated carbohydrate dephosphorylation (GO:0046838)3.33996344
35regulation of fibroblast apoptotic process (GO:2000269)3.26322011
36negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.16093019
37response to insecticide (GO:0017085)3.15349131
38alkaloid metabolic process (GO:0009820)3.14044387
39inositol phosphate catabolic process (GO:0071545)3.13943589
40positive regulation of mitochondrial fission (GO:0090141)3.09879558
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04858942
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04858942
43regulation of vesicle fusion (GO:0031338)3.03862691
44phosphorelay signal transduction system (GO:0000160)2.97421062
45piRNA metabolic process (GO:0034587)2.96778160
46segment specification (GO:0007379)2.95845485
47positive regulation of glucose metabolic process (GO:0010907)2.94501210
48negative regulation of fibroblast apoptotic process (GO:2000270)2.92271918
49behavioral response to ethanol (GO:0048149)2.91475618
50dorsal/ventral neural tube patterning (GO:0021904)2.91158037
51negative regulation of receptor activity (GO:2000272)2.90520246
52activated T cell proliferation (GO:0050798)2.87980086
53regulation of protein homooligomerization (GO:0032462)2.87164115
54positive regulation of protein depolymerization (GO:1901881)2.85526482
55regulation of vacuole organization (GO:0044088)2.83705910
56negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83153242
57carnitine metabolic process (GO:0009437)2.75754140
58cellular hyperosmotic response (GO:0071474)2.74515372
59amyloid precursor protein metabolic process (GO:0042982)2.73415639
60tolerance induction (GO:0002507)2.72822098
61embryonic epithelial tube formation (GO:0001838)2.72349949
62axonemal dynein complex assembly (GO:0070286)2.72089552
63dopamine biosynthetic process (GO:0042416)2.71794304
64protein neddylation (GO:0045116)2.71471304
65positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.69195421
66thymus development (GO:0048538)2.68006940
67cellular response to interferon-beta (GO:0035458)2.66177075
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65901432
69brain morphogenesis (GO:0048854)2.65686619
70positive regulation of cGMP biosynthetic process (GO:0030828)2.65281724
71pattern specification involved in kidney development (GO:0061004)2.65066573
72regulation of ruffle assembly (GO:1900027)2.64959325
73coenzyme A biosynthetic process (GO:0015937)2.64481457
74generation of neurons (GO:0048699)2.63148165
75regulation of cell fate specification (GO:0042659)2.61549859
76regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.60966295
77regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.60966295
78response to redox state (GO:0051775)2.60926757
79positive regulation of protein complex disassembly (GO:0043243)2.59030493
80myoblast migration (GO:0051451)2.58978453
81positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.56413834
82epithelial tube formation (GO:0072175)2.54563152
83peptidyl-lysine methylation (GO:0018022)2.54240635
84protein K48-linked deubiquitination (GO:0071108)2.52494792
85cerebral cortex neuron differentiation (GO:0021895)2.50679317
86organelle disassembly (GO:1903008)2.49785242
87regulation of cGMP biosynthetic process (GO:0030826)2.48610294
88negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.46689794
89wound healing, spreading of epidermal cells (GO:0035313)2.43738331
90beta-amyloid metabolic process (GO:0050435)2.42522848
91regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.36537875
92positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.36537875
93cGMP biosynthetic process (GO:0006182)2.35871510
94ventricular septum development (GO:0003281)2.35731277
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.34391980
96spinal cord motor neuron differentiation (GO:0021522)2.34042635
97positive regulation of mRNA catabolic process (GO:0061014)2.33198057
98ribonucleoprotein complex disassembly (GO:0032988)2.32382672
99regulation of interleukin-6 biosynthetic process (GO:0045408)2.31457444
100basic amino acid transport (GO:0015802)18.8755173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.04560271
2VDR_22108803_ChIP-Seq_LS180_Human3.96569100
3TAF15_26573619_Chip-Seq_HEK293_Human3.50522619
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11328443
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.02865566
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55363093
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54053873
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44897971
9PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse2.40020944
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.35820056
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20770404
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.18583631
13P300_19829295_ChIP-Seq_ESCs_Human2.10664504
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08898468
15BCAT_22108803_ChIP-Seq_LS180_Human2.06253219
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04279060
17EGR1_19032775_ChIP-ChIP_M12_Human2.00780617
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.81652515
19HTT_18923047_ChIP-ChIP_STHdh_Human1.79352447
20SMAD4_21799915_ChIP-Seq_A2780_Human1.78454472
21IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.75069057
22CBP_20019798_ChIP-Seq_JUKART_Human1.75069057
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71505730
24RXR_22108803_ChIP-Seq_LS180_Human1.67263640
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65952284
26ZNF274_21170338_ChIP-Seq_K562_Hela1.64532883
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62106244
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56092475
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.55129432
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54120630
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.50574866
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49894484
33TP53_16413492_ChIP-PET_HCT116_Human1.48310560
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46103441
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45540234
36RUNX_20019798_ChIP-Seq_JUKART_Human1.44524062
37PRDM14_20953172_ChIP-Seq_ESCs_Human1.42292517
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41979709
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41903297
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37685662
41EWS_26573619_Chip-Seq_HEK293_Human1.34747649
42SMRT_27268052_Chip-Seq_Bcells_Human1.34627299
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33135316
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33010577
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.32531373
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27305109
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26811922
48STAT3_23295773_ChIP-Seq_U87_Human1.26680115
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26279732
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.25828993
51SMAD4_21741376_ChIP-Seq_EPCs_Human1.24184866
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24062657
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23283180
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.22658117
55TCF4_22108803_ChIP-Seq_LS180_Human1.20955945
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20486502
57GATA3_21867929_ChIP-Seq_TH1_Mouse1.20313775
58NANOG_19829295_ChIP-Seq_ESCs_Human1.20101368
59SOX2_19829295_ChIP-Seq_ESCs_Human1.20101368
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17033606
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.15925051
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15715489
63ER_23166858_ChIP-Seq_MCF-7_Human1.14867525
64RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13898623
65CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13486939
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13259690
67JUN_21703547_ChIP-Seq_K562_Human1.11160878
68TP53_22573176_ChIP-Seq_HFKS_Human1.10470890
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10358978
70AR_25329375_ChIP-Seq_VCAP_Human1.07676633
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.07133615
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.07119539
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07119539
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.07080523
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06608527
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06264343
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06190675
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06097158
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05659348
80RUNX2_22187159_ChIP-Seq_PCA_Human1.04684247
81FUS_26573619_Chip-Seq_HEK293_Human1.03206077
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.03118382
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.02325600
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02310647
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02310647
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02215676
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00634985
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00293968
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00155692
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00084988
91P300_18555785_Chip-Seq_ESCs_Mouse0.99762223
92REST_21632747_ChIP-Seq_MESCs_Mouse0.99472607
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98674402
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.98607280
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98558397
96KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95383180
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.94772859
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.92431406
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92301596
100IRF1_19129219_ChIP-ChIP_H3396_Human0.92084748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004885_abnormal_endolymph5.27215778
2MP0000569_abnormal_digit_pigmentation5.11541428
3MP0003183_abnormal_peptide_metabolism4.08370483
4MP0005670_abnormal_white_adipose3.86293952
5MP0004185_abnormal_adipocyte_glucose3.50731934
6MP0006054_spinal_hemorrhage3.30325184
7MP0000566_synostosis3.09828722
8MP0001502_abnormal_circadian_rhythm2.40055308
9MP0005666_abnormal_adipose_tissue2.33138563
10MP0000015_abnormal_ear_pigmentation2.26285471
11MP0002102_abnormal_ear_morphology2.23140657
12MP0002909_abnormal_adrenal_gland2.22943687
13MP0003943_abnormal_hepatobiliary_system2.11618385
14MP0008877_abnormal_DNA_methylation2.10790830
15MP0001727_abnormal_embryo_implantation2.06918106
16MP0000778_abnormal_nervous_system2.04188804
17MP0001348_abnormal_lacrimal_gland2.00425578
18MP0001486_abnormal_startle_reflex1.98547855
19MP0001968_abnormal_touch/_nociception1.86837828
20MP0008872_abnormal_physiological_respon1.83911198
21MP0002837_dystrophic_cardiac_calcinosis1.69719656
22MP0004130_abnormal_muscle_cell1.69187052
23MP0001835_abnormal_antigen_presentation1.67801894
24MP0002138_abnormal_hepatobiliary_system1.66708663
25MP0001879_abnormal_lymphatic_vessel1.65913566
26MP0010368_abnormal_lymphatic_system1.64963146
27MP0009278_abnormal_bone_marrow1.64740820
28MP0002876_abnormal_thyroid_physiology1.46261384
29MP0003303_peritoneal_inflammation1.45673580
30MP0002063_abnormal_learning/memory/cond1.44950090
31MP0005671_abnormal_response_to1.44820344
32MP0003635_abnormal_synaptic_transmissio1.44602762
33MP0004381_abnormal_hair_follicle1.40833388
34MP0002638_abnormal_pupillary_reflex1.39773134
35MP0002932_abnormal_joint_morphology1.39675231
36MP0009745_abnormal_behavioral_response1.37213807
37MP0001851_eye_inflammation1.33016106
38MP0004215_abnormal_myocardial_fiber1.28307776
39MP0005174_abnormal_tail_pigmentation1.25401379
40MP0003011_delayed_dark_adaptation1.23976079
41MP0003890_abnormal_embryonic-extraembry1.22840904
42MP0005379_endocrine/exocrine_gland_phen1.20975458
43MP0001800_abnormal_humoral_immune1.19400923
44MP0005646_abnormal_pituitary_gland1.19081006
45MP0003787_abnormal_imprinting1.17000479
46MP0003938_abnormal_ear_development1.16816127
47MP0005464_abnormal_platelet_physiology1.16662301
48MP0002736_abnormal_nociception_after1.16020801
49MP0001984_abnormal_olfaction1.12274800
50MP0003436_decreased_susceptibility_to1.10890565
51MP0003329_amyloid_beta_deposits1.08829983
52MP0004133_heterotaxia1.07717297
53MP0005075_abnormal_melanosome_morpholog1.07228564
54MP0001440_abnormal_grooming_behavior1.06435775
55MP0003121_genomic_imprinting1.05528858
56MP0003763_abnormal_thymus_physiology1.05334305
57MP0009333_abnormal_splenocyte_physiolog1.01978547
58MP0005000_abnormal_immune_tolerance1.00451007
59MP0005266_abnormal_metabolism0.99992018
60MP0005448_abnormal_energy_balance0.94343256
61MP0003633_abnormal_nervous_system0.92207029
62MP0004084_abnormal_cardiac_muscle0.91833034
63MP0005360_urolithiasis0.90505114
64MP0000026_abnormal_inner_ear0.88653270
65MP0006276_abnormal_autonomic_nervous0.87977500
66MP0009785_altered_susceptibility_to0.87618864
67MP0006035_abnormal_mitochondrial_morpho0.86785849
68MP0003880_abnormal_central_pattern0.86280678
69MP0002572_abnormal_emotion/affect_behav0.85239244
70MP0005375_adipose_tissue_phenotype0.84550242
71MP0001970_abnormal_pain_threshold0.83199942
72MP0002733_abnormal_thermal_nociception0.82683181
73MP0008961_abnormal_basal_metabolism0.82343778
74MP0005220_abnormal_exocrine_pancreas0.79956726
75MP0002693_abnormal_pancreas_physiology0.78424032
76MP0002723_abnormal_immune_serum0.78147107
77MP0000249_abnormal_blood_vessel0.76178314
78MP0003122_maternal_imprinting0.76135149
79MP0001963_abnormal_hearing_physiology0.74859353
80MP0002064_seizures0.74740862
81MP0002067_abnormal_sensory_capabilities0.74205060
82MP0008569_lethality_at_weaning0.73731407
83MP0002452_abnormal_antigen_presenting0.71838428
84MP0002420_abnormal_adaptive_immunity0.71107423
85MP0003631_nervous_system_phenotype0.71076474
86MP0002148_abnormal_hypersensitivity_rea0.70769043
87MP0003191_abnormal_cellular_cholesterol0.70219152
88MP0004510_myositis0.69165912
89MP0001819_abnormal_immune_cell0.67720025
90MP0005025_abnormal_response_to0.67661858
91MP0002822_catalepsy0.67116815
92MP0000604_amyloidosis0.65855735
93MP0002928_abnormal_bile_duct0.65804021
94MP0009780_abnormal_chondrocyte_physiolo0.64000104
95MP0005551_abnormal_eye_electrophysiolog0.63966772
96MP0000427_abnormal_hair_cycle0.63632723
97MP0005377_hearing/vestibular/ear_phenot0.63357022
98MP0003878_abnormal_ear_physiology0.63357022
99MP0002405_respiratory_system_inflammati0.63171153
100MP0009764_decreased_sensitivity_to0.62556374

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)5.60166727
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.03645388
3Absent/shortened dynein arms (HP:0200106)5.03645388
4Aplasia cutis congenita (HP:0001057)4.90015834
5Abnormal ciliary motility (HP:0012262)4.62550384
6Limb dystonia (HP:0002451)4.03168341
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.00090460
8Congenital, generalized hypertrichosis (HP:0004540)3.81665018
9Abnormal respiratory epithelium morphology (HP:0012253)3.79037041
10Abnormal respiratory motile cilium morphology (HP:0005938)3.79037041
11Facial diplegia (HP:0001349)3.73739981
12Short chin (HP:0000331)3.69207601
13Tented upper lip vermilion (HP:0010804)3.53663678
14Stomach cancer (HP:0012126)3.49035637
15Polyphagia (HP:0002591)3.44932651
16Abnormal respiratory motile cilium physiology (HP:0012261)3.35449919
17Nasal polyposis (HP:0100582)3.22117790
18Ileus (HP:0002595)3.18776981
19Recurrent bacterial skin infections (HP:0005406)3.08340107
20Amyotrophic lateral sclerosis (HP:0007354)3.07665418
21Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.03486464
22Febrile seizures (HP:0002373)3.00447367
23Abnormal pupillary function (HP:0007686)2.98993963
24Fair hair (HP:0002286)2.95338323
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.88822254
26Degeneration of the lateral corticospinal tracts (HP:0002314)2.88822254
27Generalized hypopigmentation of hair (HP:0011358)2.88610227
28Chronic bronchitis (HP:0004469)2.86554438
29Sclerocornea (HP:0000647)2.80123472
30Postural instability (HP:0002172)2.78091646
31Barrel-shaped chest (HP:0001552)2.75330339
32Disproportionate short-trunk short stature (HP:0003521)2.72915965
33Thyroid-stimulating hormone excess (HP:0002925)2.71302592
34Rhinitis (HP:0012384)2.64920630
35Abnormality of the right ventricle (HP:0001707)2.62570455
36Abnormality of the nasal mucosa (HP:0000433)2.56153938
37Prolonged QT interval (HP:0001657)2.55305197
38Aplastic anemia (HP:0001915)2.52275826
39Focal seizures (HP:0007359)2.49924196
40Pancreatic fibrosis (HP:0100732)2.49575642
41Abnormality of T cell number (HP:0011839)2.48517851
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44553311
43Abnormality of alanine metabolism (HP:0010916)2.44553311
44Hyperalaninemia (HP:0003348)2.44553311
45Congenital stationary night blindness (HP:0007642)2.40013583
46Autoimmune hemolytic anemia (HP:0001890)2.38865325
47Optic nerve coloboma (HP:0000588)2.38009151
48Bile duct proliferation (HP:0001408)2.35000913
49Abnormal biliary tract physiology (HP:0012439)2.35000913
50Agnosia (HP:0010524)2.32740329
51Neoplasm of the tracheobronchial system (HP:0100552)2.32519255
52Short tibia (HP:0005736)2.28361305
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.27325908
54Male pseudohermaphroditism (HP:0000037)2.27235444
55Atonic seizures (HP:0010819)2.25382286
56Recurrent abscess formation (HP:0002722)2.23873519
57Abnormality of B cell number (HP:0010975)2.23030606
58Neurofibrillary tangles (HP:0002185)2.22692490
59Central scotoma (HP:0000603)2.22526997
60Wide intermamillary distance (HP:0006610)2.21985354
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.21397334
62Flat occiput (HP:0005469)2.20663978
63Redundant skin (HP:0001582)2.13260318
64Hip dysplasia (HP:0001385)2.12353634
65Abnormality of the aortic arch (HP:0012303)2.12309776
66Subacute progressive viral hepatitis (HP:0006572)2.11363967
67Renal cortical cysts (HP:0000803)2.10110760
68Abnormality of the tricuspid valve (HP:0001702)2.09930794
69Recurrent sinusitis (HP:0011108)2.08078394
70Autoimmune thrombocytopenia (HP:0001973)2.05770405
71Optic disc pallor (HP:0000543)2.05031274
72True hermaphroditism (HP:0010459)2.04324357
73Abnormality of the vitreous humor (HP:0004327)2.02959619
74Supranuclear gaze palsy (HP:0000605)1.99639524
75Abnormal eating behavior (HP:0100738)1.97443413
76Dry hair (HP:0011359)1.96482099
77Short 5th finger (HP:0009237)1.95925887
78Conjunctival hamartoma (HP:0100780)1.94608687
79Large for gestational age (HP:0001520)1.94286106
80Abnormality of the line of Schwalbe (HP:0008048)1.93992203
81Myokymia (HP:0002411)1.93553116
82Abnormality of the fingertips (HP:0001211)1.91918097
83Elevated erythrocyte sedimentation rate (HP:0003565)1.91708911
84Posterior embryotoxon (HP:0000627)1.91567607
85Goiter (HP:0000853)1.91491515
86T lymphocytopenia (HP:0005403)1.91068383
87Morphological abnormality of the middle ear (HP:0008609)1.89360629
88Widely spaced teeth (HP:0000687)1.88768372
89Nephronophthisis (HP:0000090)1.87572433
90Abnormal rod and cone electroretinograms (HP:0008323)1.84431655
91Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.83624905
92Volvulus (HP:0002580)1.82624091
93Choroideremia (HP:0001139)1.80687351
94Abnormality of midbrain morphology (HP:0002418)1.79176291
95Molar tooth sign on MRI (HP:0002419)1.79176291
96Pancreatic cysts (HP:0001737)1.78713289
973-Methylglutaconic aciduria (HP:0003535)1.78175681
98Alveolar cell carcinoma (HP:0006519)1.78061348
99Limb hypertonia (HP:0002509)1.72717316
100Abnormality of the axillary hair (HP:0100134)1.70930348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K116.30594920
2MAP2K44.43694029
3WNK32.43214937
4MAP3K52.35905097
5MAP3K1214.0841963
6MARK31.98375711
7MAP3K11.80057871
8KSR11.58011511
9CASK1.44651362
10STK161.15913004
11ADRBK21.06981764
12STK380.86876741
13MAP2K60.79516044
14NTRK20.74517338
15STK110.74030434
16FRK0.72359888
17PRKCI0.68334121
18DYRK20.66245314
19MAPK130.61812047
20PIM10.54308312
21MARK10.51881373
22RIPK40.51569108
23TXK0.50382587
24BMPR1B0.50064054
25CDK80.47003188
26GRK60.46481879
27TAOK30.45843296
28TRPM70.44393294
29EPHB20.42903398
30TEC0.39625444
31MAP3K90.39201050
32MST40.39040957
33FES0.37769221
34DAPK20.36458600
35EPHA40.35459902
36VRK10.35382761
37DYRK1A0.34819839
38SGK10.34679509
39PIK3CA0.34238874
40YES10.32865739
41NME10.32736129
42WNK10.32288292
43CSK0.32126643
44SYK0.30770054
45NUAK10.30382358
46BTK0.30069637
47MAP2K70.27401964
48MAP2K30.26002023
49ADRBK10.25873947
50PRKG10.25846507
51CAMK2A0.25153583
52MAP3K40.24623435
53SIK20.22342184
54EEF2K0.22161086
55PRKCZ0.22034715
56PASK0.20650675
57SIK30.20637125
58HIPK20.19293746
59ITK0.16548780
60MAPKAPK50.16420403
61ERBB30.15674273
62MATK0.15190751
63PRKACA0.14760153
64NEK10.14160201
65JAK30.13226886
66MAP3K70.12896057
67TRIM280.12353970
68MAPK40.11617863
69PIK3CG0.11515515
70PRKACG0.11130010
71CDK90.10695269
72TGFBR10.10409443
73LCK0.10359097
74PRKCQ0.10348726
75PNCK0.10292471
76OXSR10.10211547
77ACVR1B0.10026852
78SGK20.09929565
79MINK10.09251865
80HCK0.09017825
81RPS6KA50.08952788
82RET0.08758904
83MAPKAPK30.08411171
84DYRK30.08301714
85GRK50.08280203
86BCR0.07531915
87NLK0.07531244
88MAPK120.06023154
89PAK30.05324529
90MYLK0.05247322
91PRKCE0.05129953
92MAP4K10.04560377
93AKT10.04467204
94PAK10.03956782
95TNK20.03789094
96GRK70.03200241
97SGK2230.02540050
98SGK4940.02540050
99CSNK1D0.02514232
100LATS20.01773095

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.68184834
2Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.71432204
3Morphine addiction_Homo sapiens_hsa050322.49792109
4Olfactory transduction_Homo sapiens_hsa047402.38434462
5Serotonergic synapse_Homo sapiens_hsa047262.11551388
6Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.04720948
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02877958
8Phototransduction_Homo sapiens_hsa047441.95733603
9GABAergic synapse_Homo sapiens_hsa047271.93913872
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.91281600
11Oxidative phosphorylation_Homo sapiens_hsa001901.78994044
12Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.74054406
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73958619
14ErbB signaling pathway_Homo sapiens_hsa040121.72998905
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64258080
16Parkinsons disease_Homo sapiens_hsa050121.61756343
17TNF signaling pathway_Homo sapiens_hsa046681.59190632
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58662482
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54625206
20Graft-versus-host disease_Homo sapiens_hsa053321.54407555
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52655474
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49047389
23GnRH signaling pathway_Homo sapiens_hsa049121.47010065
24Taste transduction_Homo sapiens_hsa047421.44854701
25Alzheimers disease_Homo sapiens_hsa050101.36483835
26Linoleic acid metabolism_Homo sapiens_hsa005911.34570335
27Autoimmune thyroid disease_Homo sapiens_hsa053201.32684181
28Collecting duct acid secretion_Homo sapiens_hsa049661.30904413
29Allograft rejection_Homo sapiens_hsa053301.30450444
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.26044977
31Notch signaling pathway_Homo sapiens_hsa043301.25288956
32Platelet activation_Homo sapiens_hsa046111.24491002
33Cardiac muscle contraction_Homo sapiens_hsa042601.24151559
34Primary immunodeficiency_Homo sapiens_hsa053401.15584714
35Asthma_Homo sapiens_hsa053101.10210462
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08964849
37Ribosome_Homo sapiens_hsa030101.08637274
38Circadian entrainment_Homo sapiens_hsa047131.06891494
39T cell receptor signaling pathway_Homo sapiens_hsa046601.04761477
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01949458
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01591259
42Long-term depression_Homo sapiens_hsa047301.00115365
43Amphetamine addiction_Homo sapiens_hsa050310.99908429
44Hepatitis B_Homo sapiens_hsa051610.96182886
45Dorso-ventral axis formation_Homo sapiens_hsa043200.96038236
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95053752
47Cholinergic synapse_Homo sapiens_hsa047250.94883440
48Phenylalanine metabolism_Homo sapiens_hsa003600.93131082
49Renin secretion_Homo sapiens_hsa049240.89877615
50MAPK signaling pathway_Homo sapiens_hsa040100.84432418
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84274442
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.82727481
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.82312609
54Dopaminergic synapse_Homo sapiens_hsa047280.81660489
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81095020
56Rheumatoid arthritis_Homo sapiens_hsa053230.76331139
57Tyrosine metabolism_Homo sapiens_hsa003500.75672356
58Huntingtons disease_Homo sapiens_hsa050160.74182435
59mTOR signaling pathway_Homo sapiens_hsa041500.73771630
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71129871
61Influenza A_Homo sapiens_hsa051640.70526023
62Chemical carcinogenesis_Homo sapiens_hsa052040.69626296
63Osteoclast differentiation_Homo sapiens_hsa043800.69528544
64Type I diabetes mellitus_Homo sapiens_hsa049400.68378089
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67245035
66Oxytocin signaling pathway_Homo sapiens_hsa049210.66979086
67Arachidonic acid metabolism_Homo sapiens_hsa005900.66231421
68Hematopoietic cell lineage_Homo sapiens_hsa046400.63061241
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62246194
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61698956
71Epstein-Barr virus infection_Homo sapiens_hsa051690.60740236
72Non-small cell lung cancer_Homo sapiens_hsa052230.60532818
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59183630
74Cocaine addiction_Homo sapiens_hsa050300.57592257
75Type II diabetes mellitus_Homo sapiens_hsa049300.56968760
76Gap junction_Homo sapiens_hsa045400.55467637
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54878747
78Nitrogen metabolism_Homo sapiens_hsa009100.53438417
79Glutamatergic synapse_Homo sapiens_hsa047240.53363637
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52068063
81RNA degradation_Homo sapiens_hsa030180.51152300
82Histidine metabolism_Homo sapiens_hsa003400.50679284
83Ovarian steroidogenesis_Homo sapiens_hsa049130.49629548
84Measles_Homo sapiens_hsa051620.49154195
85Legionellosis_Homo sapiens_hsa051340.48279864
86Salivary secretion_Homo sapiens_hsa049700.47273073
87Antigen processing and presentation_Homo sapiens_hsa046120.46793082
88Lysine degradation_Homo sapiens_hsa003100.46458169
89Leishmaniasis_Homo sapiens_hsa051400.45165851
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.44816446
91Chemokine signaling pathway_Homo sapiens_hsa040620.44243413
92Glycerolipid metabolism_Homo sapiens_hsa005610.43521058
93Melanoma_Homo sapiens_hsa052180.42316869
94Staphylococcus aureus infection_Homo sapiens_hsa051500.37909331
95African trypanosomiasis_Homo sapiens_hsa051430.37775364
96Viral myocarditis_Homo sapiens_hsa054160.36751037
97Basal transcription factors_Homo sapiens_hsa030220.33874077
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32492610
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31782071
100Calcium signaling pathway_Homo sapiens_hsa040200.31361497

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