ANAPC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.77823315
2nuclear pore organization (GO:0006999)5.51629004
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.25830159
4mitotic sister chromatid cohesion (GO:0007064)5.18114292
5DNA unwinding involved in DNA replication (GO:0006268)5.16176488
6DNA strand elongation involved in DNA replication (GO:0006271)4.78153082
7DNA strand elongation (GO:0022616)4.61265104
8pre-miRNA processing (GO:0031054)4.39190104
9protein localization to kinetochore (GO:0034501)4.38326583
10pore complex assembly (GO:0046931)4.23303013
11mitotic chromosome condensation (GO:0007076)4.06339436
12sister chromatid segregation (GO:0000819)4.04778532
13peptidyl-lysine dimethylation (GO:0018027)3.98265172
14telomere maintenance via semi-conservative replication (GO:0032201)3.93246243
15regulation of RNA export from nucleus (GO:0046831)3.92565307
16mitotic nuclear envelope disassembly (GO:0007077)3.80439447
17non-recombinational repair (GO:0000726)3.78626327
18double-strand break repair via nonhomologous end joining (GO:0006303)3.78626327
19DNA duplex unwinding (GO:0032508)3.74403804
20regulation of histone H3-K9 methylation (GO:0051570)3.74213428
21DNA geometric change (GO:0032392)3.72745993
22heterochromatin organization (GO:0070828)3.72411134
23formation of translation preinitiation complex (GO:0001731)3.69725789
24negative regulation of histone methylation (GO:0031061)3.68212512
25regulation of mitotic spindle organization (GO:0060236)3.65867353
26nuclear envelope disassembly (GO:0051081)3.64360786
27membrane disassembly (GO:0030397)3.64360786
28DNA replication checkpoint (GO:0000076)3.62936888
29telomere maintenance via recombination (GO:0000722)3.62471636
30protein localization to chromosome, centromeric region (GO:0071459)3.59793252
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.55726459
32establishment of integrated proviral latency (GO:0075713)3.53846066
33DNA synthesis involved in DNA repair (GO:0000731)3.53386550
34regulation of spindle organization (GO:0090224)3.53094110
35regulation of sister chromatid cohesion (GO:0007063)3.53085960
36ribosome assembly (GO:0042255)3.52914876
37mitotic recombination (GO:0006312)3.52350500
38glucocorticoid receptor signaling pathway (GO:0042921)3.48586859
39chromatin assembly (GO:0031497)3.48097367
40dosage compensation (GO:0007549)3.47875040
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45764080
42negative regulation of DNA repair (GO:0045738)3.43003619
43translesion synthesis (GO:0019985)3.40654635
44cytoplasmic mRNA processing body assembly (GO:0033962)3.36328665
45regulation of translational fidelity (GO:0006450)3.36266557
46mitotic sister chromatid segregation (GO:0000070)3.35843083
47DNA replication-dependent nucleosome organization (GO:0034723)3.29079541
48DNA replication-dependent nucleosome assembly (GO:0006335)3.29079541
49regulation of DNA endoreduplication (GO:0032875)3.28902227
50mRNA stabilization (GO:0048255)3.27349979
51RNA stabilization (GO:0043489)3.27349979
52protein complex localization (GO:0031503)3.23369528
53NLS-bearing protein import into nucleus (GO:0006607)3.23196492
54hippo signaling (GO:0035329)3.18642873
55folic acid-containing compound biosynthetic process (GO:0009396)3.16188606
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.14471894
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.14471894
58positive regulation of mitotic sister chromatid separation (GO:1901970)3.14471894
59positive regulation of chromosome segregation (GO:0051984)3.13388580
60regulation of nucleobase-containing compound transport (GO:0032239)3.12068797
61meiotic chromosome segregation (GO:0045132)3.10303145
62cellular protein complex localization (GO:0034629)3.08106206
63negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07768834
64regulation of centriole replication (GO:0046599)3.06759193
65positive regulation of cell cycle checkpoint (GO:1901978)3.04525947
66V(D)J recombination (GO:0033151)3.01610142
67DNA topological change (GO:0006265)3.01082865
68regulation of histone H3-K27 methylation (GO:0061085)3.00917830
69DNA conformation change (GO:0071103)2.99231933
70establishment of chromosome localization (GO:0051303)2.98182724
71nuclear envelope organization (GO:0006998)2.97827842
72protein localization to chromosome (GO:0034502)2.97138488
73gene silencing by RNA (GO:0031047)2.97075533
74nucleobase biosynthetic process (GO:0046112)2.93324996
75chromatin assembly or disassembly (GO:0006333)2.92301781
76viral mRNA export from host cell nucleus (GO:0046784)2.91346062
77corticosteroid receptor signaling pathway (GO:0031958)2.88711611
78spliceosomal tri-snRNP complex assembly (GO:0000244)2.86024361
79histone H2A monoubiquitination (GO:0035518)2.86012199
80RNA transport (GO:0050658)2.85928664
81establishment of RNA localization (GO:0051236)2.85928664
82nucleic acid transport (GO:0050657)2.85928664
83IMP biosynthetic process (GO:0006188)2.84760495
84chromosome condensation (GO:0030261)2.84753259
85negative regulation of RNA splicing (GO:0033119)2.82643504
86paraxial mesoderm development (GO:0048339)2.78952472
87telomere maintenance (GO:0000723)2.78493384
88* negative regulation of chromosome segregation (GO:0051985)2.78491749
89gene silencing (GO:0016458)2.78322648
90nucleotide-excision repair, DNA gap filling (GO:0006297)2.78174034
91histone H3-K9 methylation (GO:0051567)2.77884124
92ribosome biogenesis (GO:0042254)2.75211955
93telomere organization (GO:0032200)2.75119793
94positive regulation of histone H3-K4 methylation (GO:0051571)2.75039007
95alternative mRNA splicing, via spliceosome (GO:0000380)2.74609180
96regulation of histone methylation (GO:0031060)2.73839737
97kinetochore organization (GO:0051383)2.72607281
98spindle assembly involved in mitosis (GO:0090307)2.71491298
99DNA replication initiation (GO:0006270)2.65911060
100regulation of centrosome cycle (GO:0046605)2.65799940
101histone-serine phosphorylation (GO:0035404)2.63972685
102attachment of spindle microtubules to kinetochore (GO:0008608)2.62909582
103microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.62469893
104regulation of centrosome duplication (GO:0010824)2.62234384
105negative regulation of histone modification (GO:0031057)2.61259371
106DNA packaging (GO:0006323)2.58833391
107postreplication repair (GO:0006301)2.58617512
108* regulation of chromosome segregation (GO:0051983)2.58390461
109regulation of DNA damage checkpoint (GO:2000001)2.57422454
110monoubiquitinated protein deubiquitination (GO:0035520)2.56949870
111negative regulation of mRNA processing (GO:0050686)2.56812426
112positive regulation of histone deacetylation (GO:0031065)2.56764660
113nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.56469720
114regulation of mRNA stability (GO:0043488)2.56360119
115insulin-like growth factor receptor signaling pathway (GO:0048009)2.56077447
116positive regulation of SMAD protein import into nucleus (GO:0060391)2.55695694
117mRNA transport (GO:0051028)2.53927782
118negative regulation of mRNA metabolic process (GO:1903312)2.51632060
119sister chromatid cohesion (GO:0007062)2.50028640
120regulation of translational termination (GO:0006449)2.47199780
121chromatin silencing (GO:0006342)2.45315192
122protein export from nucleus (GO:0006611)2.45214224
123mitotic metaphase plate congression (GO:0007080)2.44854115
124positive regulation of RNA splicing (GO:0033120)2.43719615
125metaphase plate congression (GO:0051310)2.43343013
126IMP metabolic process (GO:0046040)2.43039903
127chromosome segregation (GO:0007059)2.42033689
128negative regulation of chromatin modification (GO:1903309)2.41208485
129ATP-dependent chromatin remodeling (GO:0043044)2.40901134
130regulation of gene silencing by RNA (GO:0060966)2.40879719
131regulation of posttranscriptional gene silencing (GO:0060147)2.40879719
132regulation of gene silencing by miRNA (GO:0060964)2.40879719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.41842203
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.23049184
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08798581
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65137767
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.37996477
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.14461864
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02938362
8MYC_22102868_ChIP-Seq_BL_Human2.86118437
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.78000465
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60765131
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.55101843
12AR_21909140_ChIP-Seq_LNCAP_Human2.51655462
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.21792696
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21213361
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13287907
16E2F7_22180533_ChIP-Seq_HELA_Human10.9077351
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.82465347
18CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79012852
19* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77264319
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76841340
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.75271474
22CIITA_25753668_ChIP-Seq_RAJI_Human1.71763179
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68670127
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65878411
25DCP1A_22483619_ChIP-Seq_HELA_Human1.64133077
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61129613
27TCF7_22412390_ChIP-Seq_EML_Mouse1.57850076
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56646137
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56599654
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56503517
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55778187
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55668956
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55056902
34DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.54219397
35TTF2_22483619_ChIP-Seq_HELA_Human1.50638596
36FOXP3_21729870_ChIP-Seq_TREG_Human1.50099366
37VDR_21846776_ChIP-Seq_THP-1_Human1.48186403
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46796657
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45629684
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45621230
41CLOCK_20551151_ChIP-Seq_293T_Human1.45091697
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42187673
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41739011
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41113970
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41083782
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40993612
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40642136
48* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40175380
49FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37326015
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.36973212
51* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36416375
52* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35057500
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34151522
54KDM2B_26808549_Chip-Seq_DND41_Human1.34039979
55PKCTHETA_26484144_Chip-Seq_BREAST_Human1.33958870
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33478270
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32417744
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32364613
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31310009
60* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31255439
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.28849072
62CHD1_26751641_Chip-Seq_LNCaP_Human1.27607853
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26557292
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26374274
65* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24921389
66KDM5A_27292631_Chip-Seq_BREAST_Human1.23678508
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21301620
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20868659
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20545679
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20445681
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19620865
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19187463
73XRN2_22483619_ChIP-Seq_HELA_Human1.18750100
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17854001
75GABP_19822575_ChIP-Seq_HepG2_Human1.17019354
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16936879
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16859713
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16610954
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15402297
80* VDR_23849224_ChIP-Seq_CD4+_Human1.15382759
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15240864
82BRD4_25478319_ChIP-Seq_HGPS_Human1.15056380
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14905652
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.11116681
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10975439
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10391443
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09517663
88TP63_17297297_ChIP-ChIP_HaCaT_Human1.08944358
89UTX_26944678_Chip-Seq_JUKART_Human1.08641634
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06594389
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05866909
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04823083
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04805914
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03766166
95TFEB_21752829_ChIP-Seq_HELA_Human1.03246328
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.01762710
97* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01704006
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00518890
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99466221
100KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99066156
101ELK3_25401928_ChIP-Seq_HUVEC_Human0.98663955
102NCOR1_26117541_ChIP-Seq_K562_Human0.97733935
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97165998
104MAF_26560356_Chip-Seq_TH1_Human0.96986859
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96761436
106STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95273295
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94488806
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94337606
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93812058
110GATA1_22025678_ChIP-Seq_K562_Human0.93742217
111GABP_17652178_ChIP-ChIP_JURKAT_Human0.93723898
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92757350
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91434449
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91301457
115* SOX17_20123909_ChIP-Seq_XEN_Mouse0.91283379
116NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90938312
117ZNF263_19887448_ChIP-Seq_K562_Human0.90569868
118NOTCH1_21737748_ChIP-Seq_TLL_Human0.90277859
119KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89647731
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89444429
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89323959
122TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88645958
123ELK1_19687146_ChIP-ChIP_HELA_Human0.86858437
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84999298
125ATF3_27146783_Chip-Seq_COLON_Human0.84671345
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.81051314
127* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79853421
128MYB_26560356_Chip-Seq_TH1_Human0.79815760
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79616322
130SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79616322
131NANOG_18555785_ChIP-Seq_MESCs_Mouse0.79264632
132ISL1_27105846_Chip-Seq_CPCs_Mouse0.79110742
133SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78506947
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78054287
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77113244
136* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75286239
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.74884500
138YY1_21170310_ChIP-Seq_MESCs_Mouse0.71631215
139* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.71199773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.30264040
2MP0000569_abnormal_digit_pigmentation3.15505124
3MP0010352_gastrointestinal_tract_polyps3.09431417
4MP0010094_abnormal_chromosome_stability2.74370770
5MP0003111_abnormal_nucleus_morphology2.71327651
6MP0005076_abnormal_cell_differentiation2.66583810
7MP0002009_preneoplasia2.56880150
8MP0003123_paternal_imprinting2.56448713
9MP0010307_abnormal_tumor_latency2.36264839
10MP0003077_abnormal_cell_cycle2.30653684
11MP0003121_genomic_imprinting2.26146958
12MP0008438_abnormal_cutaneous_collagen2.18891886
13MP0009697_abnormal_copulation2.05356076
14MP0008057_abnormal_DNA_replication2.04068807
15MP0000537_abnormal_urethra_morphology2.03891566
16MP0004957_abnormal_blastocyst_morpholog2.02730576
17MP0004197_abnormal_fetal_growth/weight/1.96991728
18MP0001730_embryonic_growth_arrest1.92989872
19MP0004808_abnormal_hematopoietic_stem1.87239084
20MP0003941_abnormal_skin_development1.84984552
21MP0000350_abnormal_cell_proliferation1.81743795
22MP0002396_abnormal_hematopoietic_system1.77596812
23MP0003693_abnormal_embryo_hatching1.76504919
24MP0002084_abnormal_developmental_patter1.74184849
25MP0000733_abnormal_muscle_development1.73988020
26MP0005623_abnormal_meninges_morphology1.72915947
27MP0003300_gastrointestinal_ulcer1.72556780
28MP0005380_embryogenesis_phenotype1.68552411
29MP0001672_abnormal_embryogenesis/_devel1.68552411
30MP0008007_abnormal_cellular_replicative1.66356356
31MP0003984_embryonic_growth_retardation1.65812686
32MP0001661_extended_life_span1.65670064
33MP0002088_abnormal_embryonic_growth/wei1.64529125
34MP0006054_spinal_hemorrhage1.62997806
35MP0008877_abnormal_DNA_methylation1.59664315
36MP0002086_abnormal_extraembryonic_tissu1.59116723
37MP0002085_abnormal_embryonic_tissue1.58756895
38MP0010030_abnormal_orbit_morphology1.57636221
39MP0001697_abnormal_embryo_size1.56498823
40MP0000428_abnormal_craniofacial_morphol1.55040434
41MP0009053_abnormal_anal_canal1.49975813
42MP0003567_abnormal_fetal_cardiomyocyte1.49869791
43MP0009278_abnormal_bone_marrow1.44923621
44MP0003566_abnormal_cell_adhesion1.44556337
45MP0005451_abnormal_body_composition1.40438017
46MP0003115_abnormal_respiratory_system1.39850243
47MP0002877_abnormal_melanocyte_morpholog1.38382666
48MP0003937_abnormal_limbs/digits/tail_de1.37210298
49MP0010234_abnormal_vibrissa_follicle1.37069104
50MP0009703_decreased_birth_body1.36167411
51MP0004264_abnormal_extraembryonic_tissu1.35581270
52MP0002080_prenatal_lethality1.35017364
53MP0003890_abnormal_embryonic-extraembry1.34829923
54MP0004272_abnormal_basement_membrane1.34750362
55MP0003935_abnormal_craniofacial_develop1.32783369
56MP0003718_maternal_effect1.32639296
57MP0003787_abnormal_imprinting1.31777192
58MP0008932_abnormal_embryonic_tissue1.29511412
59MP0004233_abnormal_muscle_weight1.27567593
60MP0003786_premature_aging1.27491659
61MP0003763_abnormal_thymus_physiology1.26987858
62MP0003385_abnormal_body_wall1.25974812
63MP0001293_anophthalmia1.25951061
64MP0001915_intracranial_hemorrhage1.25722280
65MP0009672_abnormal_birth_weight1.24486505
66MP0005503_abnormal_tendon_morphology1.24441312
67MP0003221_abnormal_cardiomyocyte_apopto1.22122276
68MP0003091_abnormal_cell_migration1.21466096
69MP0001849_ear_inflammation1.18681565
70MP0002697_abnormal_eye_size1.15598215
71MP0003122_maternal_imprinting1.14597224
72MP0002925_abnormal_cardiovascular_devel1.13828564
73MP0003943_abnormal_hepatobiliary_system1.13810584
74MP0002006_tumorigenesis1.13763162
75MP0002092_abnormal_eye_morphology1.13332258
76MP0000432_abnormal_head_morphology1.10247611
77MP0005023_abnormal_wound_healing1.09258861
78MP0008058_abnormal_DNA_repair1.09249405
79MP0005187_abnormal_penis_morphology1.05646882
80MP0003942_abnormal_urinary_system1.02139573
81MP0003279_aneurysm1.01509374
82MP0001299_abnormal_eye_distance/1.01315166
83MP0004185_abnormal_adipocyte_glucose0.98250030
84MP0005275_abnormal_skin_tensile0.95711568
85MP0005384_cellular_phenotype0.94887262
86MP0002932_abnormal_joint_morphology0.92727470
87MP0000371_diluted_coat_color0.92543494
88MP0000534_abnormal_ureter_morphology0.91966372
89MP0003119_abnormal_digestive_system0.90781058
90MP0003755_abnormal_palate_morphology0.90164876
91MP0002111_abnormal_tail_morphology0.88727422
92MP0003283_abnormal_digestive_organ0.88285717
93MP0000266_abnormal_heart_morphology0.87071081
94MP0001958_emphysema0.86899822
95MP0010630_abnormal_cardiac_muscle0.86347599
96MP0010678_abnormal_skin_adnexa0.84192178
97MP0005501_abnormal_skin_physiology0.83380784
98MP0003315_abnormal_perineum_morphology0.82812126
99MP0001286_abnormal_eye_development0.82733451
100MP0000703_abnormal_thymus_morphology0.81903471
101MP0002796_impaired_skin_barrier0.80529149
102MP0000490_abnormal_crypts_of0.80434345
103MP0003861_abnormal_nervous_system0.79457580
104MP0000313_abnormal_cell_death0.79023356
105MP0009384_cardiac_valve_regurgitation0.78462455
106MP0002166_altered_tumor_susceptibility0.78141470
107MP0002116_abnormal_craniofacial_bone0.77263015
108MP0003045_fibrosis0.77205074
109MP0008770_decreased_survivor_rate0.76652712
110MP0005248_abnormal_Harderian_gland0.76173025
111MP0000358_abnormal_cell_content/0.75940769
112MP0002019_abnormal_tumor_incidence0.75850432
113MP0001784_abnormal_fluid_regulation0.74706492
114MP0002109_abnormal_limb_morphology0.73858002
115MP0000767_abnormal_smooth_muscle0.73563866
116MP0005621_abnormal_cell_physiology0.73429384
117MP0000383_abnormal_hair_follicle0.72978625
118MP0002075_abnormal_coat/hair_pigmentati0.72814149
119MP0003699_abnormal_female_reproductive0.71041343
120MP0002269_muscular_atrophy0.68440669
121MP0005409_darkened_coat_color0.68061216
122MP0000377_abnormal_hair_follicle0.67254129
123MP0002210_abnormal_sex_determination0.65183990
124MP0001929_abnormal_gametogenesis0.65107553
125MP0002398_abnormal_bone_marrow0.64099163
126MP0000477_abnormal_intestine_morphology0.63879287
127MP0006035_abnormal_mitochondrial_morpho0.61761119
128MP0000627_abnormal_mammary_gland0.60176280
129MP0001216_abnormal_epidermal_layer0.59975964
130MP0001145_abnormal_male_reproductive0.58600550
131MP0002060_abnormal_skin_morphology0.57782311
132MP0005666_abnormal_adipose_tissue0.57515117
133MP0002722_abnormal_immune_system0.57485145
134MP0005408_hypopigmentation0.54920103
135MP0005220_abnormal_exocrine_pancreas0.54667156
136MP0000598_abnormal_liver_morphology0.54038417

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.62518201
2Short 4th metacarpal (HP:0010044)4.21091682
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.21091682
4Nephroblastoma (Wilms tumor) (HP:0002667)3.62611137
5Embryonal renal neoplasm (HP:0011794)3.41590361
6Volvulus (HP:0002580)3.24047387
7Abnormality of the 4th metacarpal (HP:0010012)3.23583977
8Abnormality of chromosome stability (HP:0003220)3.20060514
9Hyperacusis (HP:0010780)3.06102136
10Cerebral aneurysm (HP:0004944)3.04219055
11Shallow orbits (HP:0000586)3.03230693
12Increased nuchal translucency (HP:0010880)2.97736933
13Abnormality of the preputium (HP:0100587)2.92268667
14Birth length less than 3rd percentile (HP:0003561)2.87937071
15Ankle contracture (HP:0006466)2.80721053
16Neoplasm of the adrenal cortex (HP:0100641)2.80490701
17Abnormality of the astrocytes (HP:0100707)2.73528527
18Astrocytoma (HP:0009592)2.73528527
19Meckel diverticulum (HP:0002245)2.68629706
20Protrusio acetabuli (HP:0003179)2.67705140
21Ependymoma (HP:0002888)2.67609244
22Subacute progressive viral hepatitis (HP:0006572)2.64678647
23Bowel diverticulosis (HP:0005222)2.63383211
24Progressive external ophthalmoplegia (HP:0000590)2.63249835
25Dysmetric saccades (HP:0000641)2.63033547
26Renal duplication (HP:0000075)2.60969097
27Overlapping toe (HP:0001845)2.60396233
28Progressive muscle weakness (HP:0003323)2.59957570
29Acute myeloid leukemia (HP:0004808)2.58654815
30Abnormality of the ileum (HP:0001549)2.58155204
31Myelodysplasia (HP:0002863)2.57957811
32Renovascular hypertension (HP:0100817)2.53650466
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.49475170
34Colon cancer (HP:0003003)2.47091740
35Increased density of long bones (HP:0006392)2.44493569
36Abnormality of the fingertips (HP:0001211)2.44446459
37Cafe-au-lait spot (HP:0000957)2.42260707
38Deviation of the thumb (HP:0009603)2.42105389
39Absent frontal sinuses (HP:0002688)2.40139900
40Selective tooth agenesis (HP:0001592)2.40054449
41Microvesicular hepatic steatosis (HP:0001414)2.39719690
42Macroorchidism (HP:0000053)2.37651949
43Proximal placement of thumb (HP:0009623)2.36003288
44Glioma (HP:0009733)2.34911376
45Elfin facies (HP:0004428)2.33240696
46Trigonocephaly (HP:0000243)2.28955975
47Long eyelashes (HP:0000527)2.28258985
48Syringomyelia (HP:0003396)2.27684829
49Spinal cord lesions (HP:0100561)2.27684829
50Missing ribs (HP:0000921)2.27361361
51Medulloblastoma (HP:0002885)2.27314301
52Duodenal stenosis (HP:0100867)2.26609269
53Small intestinal stenosis (HP:0012848)2.26609269
54Poikiloderma (HP:0001029)2.25668496
55Bladder diverticulum (HP:0000015)2.24613376
56Acute lymphatic leukemia (HP:0006721)2.22626547
57Aortic aneurysm (HP:0004942)2.19024151
58Anal stenosis (HP:0002025)2.17176516
59Heterotopia (HP:0002282)2.16555115
60Overriding aorta (HP:0002623)2.15969214
61Multiple enchondromatosis (HP:0005701)2.15785164
62Embryonal neoplasm (HP:0002898)2.15031093
63Abnormality of the carotid arteries (HP:0005344)2.14954810
64High pitched voice (HP:0001620)2.14859246
65Uterine leiomyosarcoma (HP:0002891)2.14123767
66Leiomyosarcoma (HP:0100243)2.14123767
6711 pairs of ribs (HP:0000878)2.12343979
68Abnormality of DNA repair (HP:0003254)2.10076046
69Absent radius (HP:0003974)2.09344172
70Premature rupture of membranes (HP:0001788)2.07765540
71Mitral valve prolapse (HP:0001634)2.03987282
72Broad palm (HP:0001169)2.02638934
73Reticulocytopenia (HP:0001896)2.02483194
74Skull defect (HP:0001362)2.02119564
75Gastrointestinal carcinoma (HP:0002672)2.01993541
76Malignant gastrointestinal tract tumors (HP:0006749)2.01993541
77Neoplasm of the oral cavity (HP:0100649)2.01299497
78Flat cornea (HP:0007720)2.01151128
79Cortical dysplasia (HP:0002539)2.00223597
80Narrow palate (HP:0000189)1.98638549
81Diastasis recti (HP:0001540)1.97736855
82Broad thumb (HP:0011304)1.96725455
83Obsessive-compulsive behavior (HP:0000722)1.95252781
84Ulnar bowing (HP:0003031)1.94606768
85Deviation of the hallux (HP:0010051)1.93428526
86Hallux valgus (HP:0001822)1.91995045
87Prominent nose (HP:0000448)1.91093988
88Dilatation of the ascending aorta (HP:0005111)1.90097906
89Pointed chin (HP:0000307)1.89864983
90Premature ovarian failure (HP:0008209)1.88579704
91Spastic diplegia (HP:0001264)1.87813476
92Papillary thyroid carcinoma (HP:0002895)1.87740422
93Enlarged penis (HP:0000040)1.87599793
94Ectopic kidney (HP:0000086)1.87196064
95Abnormality of the duodenum (HP:0002246)1.86776946
96Abnormality of chromosome segregation (HP:0002916)1.86220350
97Squamous cell carcinoma (HP:0002860)1.86041956
98Aplasia involving forearm bones (HP:0009822)1.85641166
99Absent forearm bone (HP:0003953)1.85641166
100High anterior hairline (HP:0009890)1.85004386
101Wrist flexion contracture (HP:0001239)1.84651214
102Transitional cell carcinoma of the bladder (HP:0006740)1.83742689
103Neoplasm of striated muscle (HP:0009728)1.82958881
104Termporal pattern (HP:0011008)1.82884617
105Insidious onset (HP:0003587)1.82884617
106Pelvic girdle muscle weakness (HP:0003749)1.82877454
107Septate vagina (HP:0001153)1.82440114
108Deep philtrum (HP:0002002)1.81927672
109Abnormality of oral frenula (HP:0000190)1.81340155
110Choanal atresia (HP:0000453)1.81053002
111Relative macrocephaly (HP:0004482)1.80632808
112Truncal obesity (HP:0001956)1.80618998
113Clubbing of toes (HP:0100760)1.80563431
114Fibrous tissue neoplasm (HP:0012316)1.80506277
115Rectal prolapse (HP:0002035)1.79886083
116Broad phalanges of the hand (HP:0009768)1.79514986
117Hypopigmentation of the fundus (HP:0007894)1.78588834
118Abnormality of the calcaneus (HP:0008364)1.77639123
119Insomnia (HP:0100785)1.77619731
120IgA deficiency (HP:0002720)1.77385459
121Sandal gap (HP:0001852)1.77299365
122Genu recurvatum (HP:0002816)1.76687344
123Cutaneous melanoma (HP:0012056)1.76114653
124Fibroma (HP:0010614)1.75631729
125Hepatoblastoma (HP:0002884)1.75348785
126Low anterior hairline (HP:0000294)1.74341163
127Neoplasm of the colon (HP:0100273)1.74080024
128Capillary hemangiomas (HP:0005306)1.73857897
129Abnormal lung lobation (HP:0002101)1.73664899
130Cutis marmorata (HP:0000965)1.73293471
131Abnormality of cochlea (HP:0000375)1.72050360
132Smooth philtrum (HP:0000319)1.72031755
133Sloping forehead (HP:0000340)1.71599337
134Entropion (HP:0000621)1.71086620
135Biliary tract neoplasm (HP:0100574)1.71041632
136Aneurysm (HP:0002617)1.70001795
137Pancreatic islet-cell hyperplasia (HP:0004510)1.69954385
138Aortic dissection (HP:0002647)1.69798052
139Rhabdomyosarcoma (HP:0002859)1.68813771
140Urethral obstruction (HP:0000796)1.68174721
141Limited elbow extension (HP:0001377)1.67962564
142Broad finger (HP:0001500)1.67927594
143Mesomelia (HP:0003027)1.67903069
144Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67514993
145Lymphangioma (HP:0100764)1.67343121
146Asymmetry of the thorax (HP:0001555)1.67282432
147Abnormality of the peritoneum (HP:0002585)1.67172721
148Bladder carcinoma (HP:0002862)1.66790390
149Bladder neoplasm (HP:0009725)1.66790390
150Pseudobulbar signs (HP:0002200)1.66486161
151Persistence of primary teeth (HP:0006335)1.65879822
152Dislocated radial head (HP:0003083)1.64855914
153Broad long bones (HP:0005622)1.64693441
154Duplication of thumb phalanx (HP:0009942)1.64549028
155Abnormality of the diencephalon (HP:0010662)1.64176257
156Chromsome breakage (HP:0040012)1.63976111
157Broad phalanx (HP:0006009)1.63923283
158Ankyloglossia (HP:0010296)1.63147779
159Exostoses (HP:0100777)1.63070402
160Basal cell carcinoma (HP:0002671)1.62811496
161Hypoplasia of the maxilla (HP:0000327)1.62792628
162Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62265746
163Abnormality of the salivary glands (HP:0010286)1.61976469
164Arteriovenous malformation (HP:0100026)1.61602506
165Megalocornea (HP:0000485)1.61376748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.98922974
2CDC73.90939981
3EEF2K3.57114410
4PKN23.36379965
5TRIB32.95514267
6LATS12.90109140
7SMG12.67183858
8MAP3K102.64127576
9NEK22.47435613
10TTN2.30096374
11SCYL22.17551186
12PBK2.02813421
13PDGFRA1.95790567
14EIF2AK11.93075696
15BRD41.77286314
16TTK1.76856914
17PTK61.66457286
18CAMK1D1.64774401
19EIF2AK31.60141186
20CDK61.59691224
21STK31.59266530
22PLK41.54346498
23PASK1.51840261
24TAF11.47655348
25ATR1.47044618
26MTOR1.46783532
27WEE11.40901968
28CDK41.38330556
29CAMK1G1.34403183
30STK101.32104538
31NEK11.29502537
32FGFR41.28866046
33RPS6KB21.28831057
34ALK1.28762950
35RIPK11.27530617
36SIK11.20390641
37MST1R1.19995122
38TGFBR11.18793573
39CHEK11.18246556
40ICK1.14764215
41FGFR11.14368707
42MKNK11.14267872
43DDR21.13707124
44MAP3K81.08556903
45PAK41.07506733
46AURKB1.07032407
47CHEK21.04837981
48PAK21.04788702
49ATM1.02037196
50SRPK11.01137585
51CDK71.01016984
52CDK91.00583436
53BMX0.98746433
54PDGFRB0.98309223
55LRRK20.97019233
56FGFR20.91832413
57STK40.91449969
58PLK30.91044555
59BRSK20.88382447
60* PLK10.88188969
61TSSK60.84785350
62CDK80.84080099
63FGFR30.83807003
64KSR20.82628960
65MELK0.82575433
66* CDK20.82527264
67FLT30.81067860
68EIF2AK20.77408068
69RPS6KA40.77011464
70DMPK0.76457379
71PNCK0.75696583
72PRPF4B0.74911406
73RET0.71939742
74MAPK110.71474051
75* CDK10.70664787
76RAF10.68399420
77NUAK10.68162547
78AURKA0.66504146
79MAP3K130.64202503
80MAP2K30.63351364
81MET0.62518971
82CSNK1A1L0.61248486
83PRKD30.60940308
84MAP3K140.60824503
85PTK20.59623217
86KSR10.59066579
87TYRO30.58289225
88ZAK0.57992992
89* PRKDC0.57503631
90ERBB40.56972639
91NEK60.56768790
92CSNK1D0.56155880
93PDK20.54583531
94NME20.54187374
95IRAK30.52880795
96TLK10.52409888
97MKNK20.51861185
98JAK30.51312751
99LATS20.51143827
100WNK10.50937782
101MAPK140.50680133
102NEK90.50614714
103CSF1R0.48722059
104PIM10.45865756
105SIK20.44408882
106VRK10.43558434
107CDK30.43471635
108BRAF0.42776410
109AKT10.42448048
110AKT20.42324084
111PRKCH0.40082509
112CSNK2A20.39978382
113MAP3K90.39871520
114ERBB20.39500184
115YES10.39064353
116CLK10.37934202
117ACVR1B0.37591623
118MAPK10.37563355
119* GSK3B0.37174979
120CSNK1E0.37124432
121BUB10.36951663
122TESK20.36926104
123NLK0.36542199
124STK38L0.35720804
125CHUK0.34617741
126BRSK10.34113276
127EGFR0.33074214
128MAP3K70.32515148
129SGK30.31785927
130TRPM70.31518799
131BMPR20.30845021
132RPS6KB10.30652511
133MAPK100.30179397

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.48327313
2* Cell cycle_Homo sapiens_hsa041102.45185137
3One carbon pool by folate_Homo sapiens_hsa006702.23409864
4RNA transport_Homo sapiens_hsa030132.14259440
5Mismatch repair_Homo sapiens_hsa034302.10661293
6mRNA surveillance pathway_Homo sapiens_hsa030152.01016410
7MicroRNAs in cancer_Homo sapiens_hsa052061.85549925
8Chronic myeloid leukemia_Homo sapiens_hsa052201.84174376
9Spliceosome_Homo sapiens_hsa030401.81524140
10Small cell lung cancer_Homo sapiens_hsa052221.78615047
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74918491
12Systemic lupus erythematosus_Homo sapiens_hsa053221.72664275
13Lysine degradation_Homo sapiens_hsa003101.72651514
14Adherens junction_Homo sapiens_hsa045201.66746352
15Viral carcinogenesis_Homo sapiens_hsa052031.58149757
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54412147
17Basal cell carcinoma_Homo sapiens_hsa052171.52456295
18Biosynthesis of amino acids_Homo sapiens_hsa012301.51031917
19Proteoglycans in cancer_Homo sapiens_hsa052051.47401001
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46049527
21Colorectal cancer_Homo sapiens_hsa052101.42437094
22mTOR signaling pathway_Homo sapiens_hsa041501.41749649
23Base excision repair_Homo sapiens_hsa034101.40473717
24Focal adhesion_Homo sapiens_hsa045101.39962491
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39454388
26* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37896578
27* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37713334
28Selenocompound metabolism_Homo sapiens_hsa004501.37589585
29Hippo signaling pathway_Homo sapiens_hsa043901.36720494
30Nucleotide excision repair_Homo sapiens_hsa034201.35871067
31Fanconi anemia pathway_Homo sapiens_hsa034601.34748265
32ECM-receptor interaction_Homo sapiens_hsa045121.31652729
33* HTLV-I infection_Homo sapiens_hsa051661.30553673
34p53 signaling pathway_Homo sapiens_hsa041151.29646189
35Viral myocarditis_Homo sapiens_hsa054161.27124341
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.26935441
37Non-small cell lung cancer_Homo sapiens_hsa052231.26809109
38Endometrial cancer_Homo sapiens_hsa052131.25015263
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21138528
40Pancreatic cancer_Homo sapiens_hsa052121.20747175
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.19872539
42Non-homologous end-joining_Homo sapiens_hsa034501.18594213
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17457094
44Glioma_Homo sapiens_hsa052141.16750397
45Pyrimidine metabolism_Homo sapiens_hsa002401.14689462
46TGF-beta signaling pathway_Homo sapiens_hsa043501.13816368
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13408972
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10000981
49Basal transcription factors_Homo sapiens_hsa030221.09896267
50Prostate cancer_Homo sapiens_hsa052151.09845751
51Notch signaling pathway_Homo sapiens_hsa043301.08205258
52Alcoholism_Homo sapiens_hsa050341.06009630
53* Oocyte meiosis_Homo sapiens_hsa041141.05011472
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02244078
55Homologous recombination_Homo sapiens_hsa034401.01511968
56Hedgehog signaling pathway_Homo sapiens_hsa043401.00391448
57Pathways in cancer_Homo sapiens_hsa052000.97737322
58RNA degradation_Homo sapiens_hsa030180.97467902
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96673279
60Pentose phosphate pathway_Homo sapiens_hsa000300.96590224
61Bladder cancer_Homo sapiens_hsa052190.95920307
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.95780772
63Renal cell carcinoma_Homo sapiens_hsa052110.93769900
64Thyroid cancer_Homo sapiens_hsa052160.91865687
65Wnt signaling pathway_Homo sapiens_hsa043100.89642162
66RNA polymerase_Homo sapiens_hsa030200.88645883
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.88599182
68Carbon metabolism_Homo sapiens_hsa012000.88431915
69Hepatitis B_Homo sapiens_hsa051610.88151528
70Antigen processing and presentation_Homo sapiens_hsa046120.83559061
71Herpes simplex infection_Homo sapiens_hsa051680.83514582
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83057675
73Acute myeloid leukemia_Homo sapiens_hsa052210.82275990
74Platelet activation_Homo sapiens_hsa046110.81775180
75Dorso-ventral axis formation_Homo sapiens_hsa043200.80016414
76HIF-1 signaling pathway_Homo sapiens_hsa040660.78885101
77FoxO signaling pathway_Homo sapiens_hsa040680.78712606
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77363374
79Toxoplasmosis_Homo sapiens_hsa051450.77090479
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76890247
81Epstein-Barr virus infection_Homo sapiens_hsa051690.76804325
82AMPK signaling pathway_Homo sapiens_hsa041520.74596461
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73880673
84Melanoma_Homo sapiens_hsa052180.73846252
85Vitamin B6 metabolism_Homo sapiens_hsa007500.73606045
86Purine metabolism_Homo sapiens_hsa002300.73545870
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72953020
88B cell receptor signaling pathway_Homo sapiens_hsa046620.72845664
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71787341
90Tight junction_Homo sapiens_hsa045300.70355489
91Pyruvate metabolism_Homo sapiens_hsa006200.69525084
92Amoebiasis_Homo sapiens_hsa051460.68890421
93Estrogen signaling pathway_Homo sapiens_hsa049150.68736886
94VEGF signaling pathway_Homo sapiens_hsa043700.67370708
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66722769
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66608729
97Apoptosis_Homo sapiens_hsa042100.66117011
98Insulin signaling pathway_Homo sapiens_hsa049100.65932828
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64523145
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63925210
101Insulin resistance_Homo sapiens_hsa049310.63915780
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62710072
103Prolactin signaling pathway_Homo sapiens_hsa049170.61592495
104Rap1 signaling pathway_Homo sapiens_hsa040150.61186923
105ErbB signaling pathway_Homo sapiens_hsa040120.60236054
106Ribosome_Homo sapiens_hsa030100.59200733
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58628224
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58628138
109Shigellosis_Homo sapiens_hsa051310.58223414
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57788422
111T cell receptor signaling pathway_Homo sapiens_hsa046600.57725470
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56288330
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54155781
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53879369
115Melanogenesis_Homo sapiens_hsa049160.53856300
116Type II diabetes mellitus_Homo sapiens_hsa049300.53550274
117N-Glycan biosynthesis_Homo sapiens_hsa005100.49546994
118Dilated cardiomyopathy_Homo sapiens_hsa054140.49172422
119Measles_Homo sapiens_hsa051620.49134437
120Inositol phosphate metabolism_Homo sapiens_hsa005620.46588126
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39719710
122Arginine biosynthesis_Homo sapiens_hsa002200.39342679
123Proteasome_Homo sapiens_hsa030500.36845913
124Choline metabolism in cancer_Homo sapiens_hsa052310.36177676
125Fatty acid biosynthesis_Homo sapiens_hsa000610.35272592
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33573600
127Glucagon signaling pathway_Homo sapiens_hsa049220.28098557
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27306878
129Influenza A_Homo sapiens_hsa051640.25721264

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