ANAPC10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.04605484
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.94900392
3mitotic metaphase plate congression (GO:0007080)4.36817227
4purine nucleobase biosynthetic process (GO:0009113)4.35481531
5kinetochore assembly (GO:0051382)4.31772774
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.27413685
7ATP synthesis coupled proton transport (GO:0015986)4.23084947
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.23084947
9ribosome assembly (GO:0042255)4.18984495
10kinetochore organization (GO:0051383)4.09444573
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.04641940
12chaperone-mediated protein transport (GO:0072321)4.03547653
13protein neddylation (GO:0045116)4.03323697
14rRNA modification (GO:0000154)4.01225269
15termination of RNA polymerase III transcription (GO:0006386)3.99479712
16transcription elongation from RNA polymerase III promoter (GO:0006385)3.99479712
17cullin deneddylation (GO:0010388)3.91277946
18protein complex biogenesis (GO:0070271)3.90637137
19mitochondrial respiratory chain complex assembly (GO:0033108)3.90432694
20DNA deamination (GO:0045006)3.89716705
21nucleobase biosynthetic process (GO:0046112)3.88254608
227-methylguanosine mRNA capping (GO:0006370)3.87984775
23CENP-A containing nucleosome assembly (GO:0034080)3.85312479
24RNA capping (GO:0036260)3.81140108
257-methylguanosine RNA capping (GO:0009452)3.81140108
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.80930176
27termination of RNA polymerase I transcription (GO:0006363)3.77945956
28ribosome biogenesis (GO:0042254)3.75660608
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.71506959
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.71506959
31NADH dehydrogenase complex assembly (GO:0010257)3.71506959
32protein deneddylation (GO:0000338)3.71018893
33* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.70106938
34* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67852275
35transcription elongation from RNA polymerase I promoter (GO:0006362)3.67832483
36protein K6-linked ubiquitination (GO:0085020)3.67411846
37* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66944387
38* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.66600711
39transcription from RNA polymerase I promoter (GO:0006360)3.66129790
40DNA replication checkpoint (GO:0000076)3.64961688
41chromatin remodeling at centromere (GO:0031055)3.64011871
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.60422801
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.60422801
44metaphase plate congression (GO:0051310)3.57522449
45respiratory electron transport chain (GO:0022904)3.56517636
46electron transport chain (GO:0022900)3.52301039
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.51014407
48protein-cofactor linkage (GO:0018065)3.50465648
49regulation of nuclear cell cycle DNA replication (GO:0033262)3.36746337
50transcription initiation from RNA polymerase I promoter (GO:0006361)3.30048258
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.30032569
52signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29989780
53signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29989780
54signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29989780
55respiratory chain complex IV assembly (GO:0008535)3.29248836
56organelle disassembly (GO:1903008)3.28559349
57peptidyl-histidine modification (GO:0018202)3.27706291
58ribonucleoprotein complex biogenesis (GO:0022613)3.27329267
59ribosomal large subunit biogenesis (GO:0042273)3.26033552
60oxidative phosphorylation (GO:0006119)3.25948515
61DNA replication-independent nucleosome organization (GO:0034724)3.24017336
62DNA replication-independent nucleosome assembly (GO:0006336)3.24017336
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23753923
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23753923
65* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.22902949
66maturation of 5.8S rRNA (GO:0000460)3.21990658
67* negative regulation of ligase activity (GO:0051352)3.21102173
68* negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21102173
69establishment of chromosome localization (GO:0051303)3.20683837
70telomere maintenance via semi-conservative replication (GO:0032201)3.20238941
71regulation of cellular amino acid metabolic process (GO:0006521)3.19292014
72establishment of integrated proviral latency (GO:0075713)3.19151136
73rRNA methylation (GO:0031167)3.19031696
74histone exchange (GO:0043486)3.19011983
75signal transduction involved in DNA damage checkpoint (GO:0072422)3.18067387
76signal transduction involved in DNA integrity checkpoint (GO:0072401)3.18067387
77meiotic chromosome segregation (GO:0045132)3.17528762
78telomere maintenance via recombination (GO:0000722)3.16108926
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.15807125
80DNA replication initiation (GO:0006270)3.12378426
81regulation of mitochondrial translation (GO:0070129)3.11648084
82regulation of double-strand break repair via homologous recombination (GO:0010569)3.10806595
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.10293591
84DNA strand elongation involved in DNA replication (GO:0006271)3.09134348
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09065500
86spliceosomal snRNP assembly (GO:0000387)3.08799570
87L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08703090
88transcription-coupled nucleotide-excision repair (GO:0006283)3.08215645
89rRNA processing (GO:0006364)3.07177255
90maturation of SSU-rRNA (GO:0030490)3.07159651
91nucleotide-excision repair, DNA gap filling (GO:0006297)3.05751833
92metallo-sulfur cluster assembly (GO:0031163)3.05547592
93iron-sulfur cluster assembly (GO:0016226)3.05547592
94* positive regulation of ligase activity (GO:0051351)3.04945343
95cytochrome complex assembly (GO:0017004)3.03918610
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.02431925
97maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01282444
98histone mRNA metabolic process (GO:0008334)3.00875961
99response to X-ray (GO:0010165)2.99162085
100G1/S transition of mitotic cell cycle (GO:0000082)2.99112360
101cell cycle G1/S phase transition (GO:0044843)2.99112360
102DNA strand elongation (GO:0022616)2.98908196
103rRNA metabolic process (GO:0016072)2.98195100
104formation of translation preinitiation complex (GO:0001731)2.97718815
105negative regulation of DNA-dependent DNA replication (GO:2000104)2.96193357
106DNA-dependent DNA replication (GO:0006261)2.94476603
107recombinational repair (GO:0000725)2.93176354
108protein localization to kinetochore (GO:0034501)2.93051867
109reciprocal DNA recombination (GO:0035825)2.92952761
110reciprocal meiotic recombination (GO:0007131)2.92952761
111pseudouridine synthesis (GO:0001522)2.92332502
112DNA synthesis involved in DNA repair (GO:0000731)2.92207164
113double-strand break repair via homologous recombination (GO:0000724)2.91640003
114somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91222040
115somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91222040
116isotype switching (GO:0045190)2.91222040
117water-soluble vitamin biosynthetic process (GO:0042364)2.90946909
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90571147
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.90571147
120lactate metabolic process (GO:0006089)2.89695156
121DNA catabolic process, exonucleolytic (GO:0000738)2.89331762
122synapsis (GO:0007129)2.88533442
123mitotic recombination (GO:0006312)2.87925953
124male meiosis I (GO:0007141)2.87896909
125replication fork processing (GO:0031297)2.87279037
126attachment of spindle microtubules to kinetochore (GO:0008608)2.87199928
127mitochondrial RNA metabolic process (GO:0000959)2.86715941
128transcription elongation from RNA polymerase II promoter (GO:0006368)2.86586684
129telomere maintenance via telomere lengthening (GO:0010833)2.85849491
130DNA double-strand break processing (GO:0000729)2.83038973
131guanosine-containing compound biosynthetic process (GO:1901070)2.81996667
132ribonucleoprotein complex disassembly (GO:0032988)2.80591384
133RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.80185561
134tRNA processing (GO:0008033)2.79806165
135regulation of mitotic spindle checkpoint (GO:1903504)2.79541436
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79541436
137DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.78198808
138platelet dense granule organization (GO:0060155)2.77654187
139DNA ligation (GO:0006266)2.77143290
140piRNA metabolic process (GO:0034587)2.76679623
141DNA-templated transcription, elongation (GO:0006354)2.76323930
142ribosomal small subunit assembly (GO:0000028)2.75942416
143viral mRNA export from host cell nucleus (GO:0046784)2.75155143
144* regulation of ubiquitin-protein transferase activity (GO:0051438)2.71783903
145* regulation of ligase activity (GO:0051340)2.71532234
146cellular component biogenesis (GO:0044085)2.69647116
147regulation of glucokinase activity (GO:0033131)2.69155202
148regulation of hexokinase activity (GO:1903299)2.69155202
149positive regulation of cell cycle arrest (GO:0071158)2.66589363
150regulation of spindle organization (GO:0090224)2.66183499
151microtubule depolymerization (GO:0007019)2.65189002
152exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64814734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.85266416
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26892639
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.84846482
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.79164063
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.67883155
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.56676302
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.55779519
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27843426
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.12852734
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.90108758
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82431130
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.77159071
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77057240
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71098121
15* VDR_23849224_ChIP-Seq_CD4+_Human2.63115208
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58108901
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54233361
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.54073991
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54006852
20VDR_22108803_ChIP-Seq_LS180_Human2.48565177
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48503123
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43603721
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42052263
24ZNF274_21170338_ChIP-Seq_K562_Hela2.31207788
25ELK1_19687146_ChIP-ChIP_HELA_Human2.28143453
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19977864
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16015412
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.15710288
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04192452
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02390449
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99545673
32FOXP3_21729870_ChIP-Seq_TREG_Human1.98703559
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97788139
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94579753
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93626189
36DCP1A_22483619_ChIP-Seq_HELA_Human1.93071838
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92587850
38IGF1R_20145208_ChIP-Seq_DFB_Human1.92389932
39FUS_26573619_Chip-Seq_HEK293_Human1.89788273
40* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87648844
41EWS_26573619_Chip-Seq_HEK293_Human1.86849441
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80837180
43GABP_19822575_ChIP-Seq_HepG2_Human1.76991583
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.74605390
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74014232
46XRN2_22483619_ChIP-Seq_HELA_Human1.73732568
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.72457519
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69794278
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66495616
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66408464
51AR_21909140_ChIP-Seq_LNCAP_Human1.63401708
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.61846197
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61599233
54* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61161107
55* TAF15_26573619_Chip-Seq_HEK293_Human1.60270894
56TTF2_22483619_ChIP-Seq_HELA_Human1.58055690
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.53292713
58KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52461990
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52337826
60* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50480452
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.49977287
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.47927795
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47275746
64* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46560512
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45150164
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45002228
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44879696
68* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38182494
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.37376152
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36008777
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34418626
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.34022437
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33700500
74IRF1_19129219_ChIP-ChIP_H3396_Human1.28033485
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.27245981
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26429970
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26273635
78P300_19829295_ChIP-Seq_ESCs_Human1.26128989
79* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22516823
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19911969
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18167772
82TP53_22573176_ChIP-Seq_HFKS_Human1.17198789
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16389640
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16369160
85ER_23166858_ChIP-Seq_MCF-7_Human1.12628991
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12598012
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12161335
88* SPI1_23547873_ChIP-Seq_NB4_Human1.11498416
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.08558156
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08403462
91KDM5A_27292631_Chip-Seq_BREAST_Human1.04852926
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03758575
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03589267
94CBP_20019798_ChIP-Seq_JUKART_Human1.03589267
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03546099
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.01862770
97* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01376452
98MYC_18940864_ChIP-ChIP_HL60_Human0.98928934
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98828134
100FOXA1_25329375_ChIP-Seq_VCAP_Human0.98828134
101BCAT_22108803_ChIP-Seq_LS180_Human0.98353477
102IRF8_22096565_ChIP-ChIP_GC-B_Human0.98087339
103POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97521851
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97204633
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97204633
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97204633
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96463193
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96347548
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.94536355
110SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93433075
111GBX2_23144817_ChIP-Seq_PC3_Human0.92424679
112NANOG_16153702_ChIP-ChIP_HESCs_Human0.91669247
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90141066
114FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89911421
115SOX2_19829295_ChIP-Seq_ESCs_Human0.89895949
116NANOG_19829295_ChIP-Seq_ESCs_Human0.89895949
117HTT_18923047_ChIP-ChIP_STHdh_Human0.89274424
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88505309
119ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88193936
120AR_20517297_ChIP-Seq_VCAP_Human0.85946051
121KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84637065
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84089271
123NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83637024
124SOX17_20123909_ChIP-Seq_XEN_Mouse0.80817769
125SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80741173
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80646410
127TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79901011
128PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79643269
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79007603
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76164378
131SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76158671
132CIITA_25753668_ChIP-Seq_RAJI_Human0.75696491
133TFEB_21752829_ChIP-Seq_HELA_Human0.74840970
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74703949
135CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.73299334
136RBPJ_22232070_ChIP-Seq_NCS_Mouse0.72301884
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.71155334
138POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.70085927
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.70014522
140STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.68689598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.47719818
2MP0003111_abnormal_nucleus_morphology3.81562722
3MP0010094_abnormal_chromosome_stability3.65863053
4MP0008058_abnormal_DNA_repair3.58920925
5MP0004957_abnormal_blastocyst_morpholog3.34570045
6MP0003718_maternal_effect3.22807509
7MP0003077_abnormal_cell_cycle3.04935862
8MP0008057_abnormal_DNA_replication2.90337717
9MP0008260_abnormal_autophagy2.64485385
10MP0006072_abnormal_retinal_apoptosis2.60794534
11MP0003786_premature_aging2.37570275
12MP0008007_abnormal_cellular_replicative2.36374591
13MP0008932_abnormal_embryonic_tissue2.25441032
14MP0008877_abnormal_DNA_methylation2.15949654
15MP0003806_abnormal_nucleotide_metabolis2.08539013
16MP0003941_abnormal_skin_development2.02498928
17MP0006292_abnormal_olfactory_placode2.02408919
18MP0003136_yellow_coat_color1.99640323
19MP0006036_abnormal_mitochondrial_physio1.98374051
20MP0004147_increased_porphyrin_level1.97830957
21MP0003252_abnormal_bile_duct1.91317335
22MP0002396_abnormal_hematopoietic_system1.86603842
23MP0000569_abnormal_digit_pigmentation1.85367450
24MP0003195_calcinosis1.84674178
25MP0008789_abnormal_olfactory_epithelium1.83022714
26MP0001188_hyperpigmentation1.82132415
27MP0005084_abnormal_gallbladder_morpholo1.78064031
28MP0009697_abnormal_copulation1.77169723
29MP0009333_abnormal_splenocyte_physiolog1.76233933
30MP0005253_abnormal_eye_physiology1.76077107
31MP0000015_abnormal_ear_pigmentation1.75332034
32MP0001529_abnormal_vocalization1.74226582
33MP0003011_delayed_dark_adaptation1.69917546
34MP0001835_abnormal_antigen_presentation1.68167735
35MP0002102_abnormal_ear_morphology1.67720062
36MP0002234_abnormal_pharynx_morphology1.67200059
37MP0002736_abnormal_nociception_after1.63489163
38MP0002132_abnormal_respiratory_system1.58140408
39MP0000490_abnormal_crypts_of1.54861520
40MP0002277_abnormal_respiratory_mucosa1.50847109
41MP0003315_abnormal_perineum_morphology1.44711324
42MP0002148_abnormal_hypersensitivity_rea1.44513931
43MP0005551_abnormal_eye_electrophysiolog1.44329987
44MP0005646_abnormal_pituitary_gland1.44078109
45MP0003186_abnormal_redox_activity1.43715639
46MP0003890_abnormal_embryonic-extraembry1.43007352
47MP0002210_abnormal_sex_determination1.39222447
48MP0001542_abnormal_bone_strength1.39132985
49MP0005671_abnormal_response_to1.34269104
50MP0003880_abnormal_central_pattern1.32730066
51MP0005174_abnormal_tail_pigmentation1.31503728
52MP0005645_abnormal_hypothalamus_physiol1.31429316
53MP0001764_abnormal_homeostasis1.31169255
54MP0005389_reproductive_system_phenotype1.30706100
55MP0009785_altered_susceptibility_to1.30446111
56MP0003950_abnormal_plasma_membrane1.29916938
57MP0002160_abnormal_reproductive_system1.27067386
58MP0004782_abnormal_surfactant_physiolog1.26957246
59MP0001119_abnormal_female_reproductive1.26745205
60MP0002837_dystrophic_cardiac_calcinosis1.26005300
61MP0000631_abnormal_neuroendocrine_gland1.25858339
62MP0005499_abnormal_olfactory_system1.24779926
63MP0005394_taste/olfaction_phenotype1.24779926
64MP0001545_abnormal_hematopoietic_system1.22504000
65MP0005397_hematopoietic_system_phenotyp1.22504000
66MP0003123_paternal_imprinting1.21995841
67MP0002095_abnormal_skin_pigmentation1.19737008
68MP0004808_abnormal_hematopoietic_stem1.17512213
69MP0003724_increased_susceptibility_to1.17135291
70MP0005395_other_phenotype1.16487980
71MP0003567_abnormal_fetal_cardiomyocyte1.16475399
72MP0001986_abnormal_taste_sensitivity1.15822234
73MP0002638_abnormal_pupillary_reflex1.14781535
74MP0010307_abnormal_tumor_latency1.13453322
75MP0000358_abnormal_cell_content/1.13145602
76MP0001145_abnormal_male_reproductive1.12465952
77MP0000350_abnormal_cell_proliferation1.10868407
78MP0002163_abnormal_gland_morphology1.10150883
79MP0001919_abnormal_reproductive_system1.08704439
80MP0004215_abnormal_myocardial_fiber1.08170328
81MP0001984_abnormal_olfaction1.06881244
82MP0005075_abnormal_melanosome_morpholog1.06683477
83MP0000566_synostosis1.04178004
84MP0002452_abnormal_antigen_presenting1.02814571
85MP0001929_abnormal_gametogenesis1.01736733
86MP0000653_abnormal_sex_gland1.01629999
87MP0002419_abnormal_innate_immunity1.00387108
88MP0000313_abnormal_cell_death0.98702449
89MP0010386_abnormal_urinary_bladder0.96354272
90MP0005000_abnormal_immune_tolerance0.96017787
91MP0002282_abnormal_trachea_morphology0.95831442
92MP0001730_embryonic_growth_arrest0.95533195
93MP0005025_abnormal_response_to0.95527061
94MP0003698_abnormal_male_reproductive0.94862953
95MP0002751_abnormal_autonomic_nervous0.94775702
96MP0002723_abnormal_immune_serum0.94327278
97MP0000647_abnormal_sebaceous_gland0.93207820
98MP0001968_abnormal_touch/_nociception0.92441095
99MP0003646_muscle_fatigue0.92419522
100MP0002398_abnormal_bone_marrow0.91639312
101MP0005410_abnormal_fertilization0.90649039
102MP0001672_abnormal_embryogenesis/_devel0.90643885
103MP0005380_embryogenesis_phenotype0.90643885
104MP0002938_white_spotting0.89622356
105MP0003878_abnormal_ear_physiology0.88433802
106MP0005377_hearing/vestibular/ear_phenot0.88433802
107MP0006276_abnormal_autonomic_nervous0.87637039
108MP0001819_abnormal_immune_cell0.87142693
109MP0009046_muscle_twitch0.87097961
110MP0006035_abnormal_mitochondrial_morpho0.86998967
111MP0001853_heart_inflammation0.86945604
112MP0000516_abnormal_urinary_system0.86791267
113MP0005367_renal/urinary_system_phenotyp0.86791267
114MP0001485_abnormal_pinna_reflex0.86561743
115MP0009745_abnormal_behavioral_response0.86486656
116MP0000427_abnormal_hair_cycle0.86442583
117MP0008872_abnormal_physiological_respon0.86016174
118MP0001800_abnormal_humoral_immune0.85312168
119MP0002019_abnormal_tumor_incidence0.84990611
120MP0002420_abnormal_adaptive_immunity0.84033095
121MP0003937_abnormal_limbs/digits/tail_de0.83276526
122MP0003121_genomic_imprinting0.82868695
123MP0005391_vision/eye_phenotype0.81255962
124MP0008875_abnormal_xenobiotic_pharmacok0.81035922
125MP0000372_irregular_coat_pigmentation0.80277669
126MP0003137_abnormal_impulse_conducting0.80150041
127MP0004381_abnormal_hair_follicle0.79460640
128MP0004142_abnormal_muscle_tone0.78941902
129MP0002876_abnormal_thyroid_physiology0.78922941
130MP0000716_abnormal_immune_system0.78516892
131MP0002722_abnormal_immune_system0.77399921
132MP0000858_altered_metastatic_potential0.77118603
133MP0004133_heterotaxia0.76892288
134MP0005451_abnormal_body_composition0.76816290
135MP0003436_decreased_susceptibility_to0.76580133
136MP0001697_abnormal_embryo_size0.76453285
137MP0000689_abnormal_spleen_morphology0.76213599
138MP0005058_abnormal_lysosome_morphology0.75900205
139MP0002429_abnormal_blood_cell0.75656060
140MP0002090_abnormal_vision0.74987252
141MP0003448_altered_tumor_morphology0.74156829
142MP0002084_abnormal_developmental_patter0.73641156
143MP0000627_abnormal_mammary_gland0.73483027
144MP0003119_abnormal_digestive_system0.73076873
145MP0001293_anophthalmia0.72878786
146MP0006082_CNS_inflammation0.72820707
147MP0008995_early_reproductive_senescence0.71942557
148MP0005408_hypopigmentation0.71941765
149MP0001905_abnormal_dopamine_level0.71615394
150MP0000371_diluted_coat_color0.71303134
151MP0001501_abnormal_sleep_pattern0.69756259
152MP0003936_abnormal_reproductive_system0.69000075
153MP0001324_abnormal_eye_pigmentation0.68911269
154MP0003763_abnormal_thymus_physiology0.67832942
155MP0005636_abnormal_mineral_homeostasis0.67544790
156MP0002233_abnormal_nose_morphology0.67524271

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.77052454
2Chromsome breakage (HP:0040012)4.59566365
3Birth length less than 3rd percentile (HP:0003561)4.44624443
4Acute necrotizing encephalopathy (HP:0006965)4.08956026
5Increased CSF lactate (HP:0002490)3.76313963
6Mitochondrial inheritance (HP:0001427)3.74158497
7Breast hypoplasia (HP:0003187)3.70216392
8Abnormal mitochondria in muscle tissue (HP:0008316)3.69591857
9Acute encephalopathy (HP:0006846)3.60891968
10Meckel diverticulum (HP:0002245)3.48546185
11Progressive macrocephaly (HP:0004481)3.46269125
12Increased hepatocellular lipid droplets (HP:0006565)3.40305474
13Abnormality of the preputium (HP:0100587)3.36338449
14Abnormality of the ileum (HP:0001549)3.26434727
15Hepatocellular necrosis (HP:0001404)3.24827919
16Lipid accumulation in hepatocytes (HP:0006561)3.23007081
17Rough bone trabeculation (HP:0100670)3.21317390
18Hepatic necrosis (HP:0002605)3.13787211
19Carpal bone hypoplasia (HP:0001498)3.11275062
20Abnormality of midbrain morphology (HP:0002418)3.09703524
21Molar tooth sign on MRI (HP:0002419)3.09703524
22Abnormality of chromosome stability (HP:0003220)2.99508580
23Patellar aplasia (HP:0006443)2.96692337
24Type I transferrin isoform profile (HP:0003642)2.96388248
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.91734360
26Aplasia/Hypoplasia of the patella (HP:0006498)2.84409546
27Methylmalonic acidemia (HP:0002912)2.83977504
28Renal Fanconi syndrome (HP:0001994)2.82230753
29Increased serum lactate (HP:0002151)2.78460993
30Absent radius (HP:0003974)2.73249282
31Prostate neoplasm (HP:0100787)2.71067024
32True hermaphroditism (HP:0010459)2.70515272
33Congenital, generalized hypertrichosis (HP:0004540)2.68840037
34Type 2 muscle fiber atrophy (HP:0003554)2.62012445
35Abnormal trabecular bone morphology (HP:0100671)2.61489264
36Abnormal spermatogenesis (HP:0008669)2.61283531
37Reticulocytopenia (HP:0001896)2.61279969
38Cerebral edema (HP:0002181)2.59097114
39Bone marrow hypocellularity (HP:0005528)2.58096132
40Lactic acidosis (HP:0003128)2.57189068
41Absent forearm bone (HP:0003953)2.54734558
42Aplasia involving forearm bones (HP:0009822)2.54734558
43Nephronophthisis (HP:0000090)2.54379448
44Methylmalonic aciduria (HP:0012120)2.53660104
45Cleft eyelid (HP:0000625)2.52949443
46Small intestinal stenosis (HP:0012848)2.49580901
47Duodenal stenosis (HP:0100867)2.49580901
48Impulsivity (HP:0100710)2.48141895
49Pendular nystagmus (HP:0012043)2.41580056
50Muscle fiber atrophy (HP:0100295)2.39283876
51Clubbing of toes (HP:0100760)2.39056232
52Sparse eyelashes (HP:0000653)2.38645126
53Premature graying of hair (HP:0002216)2.37856506
54Poor head control (HP:0002421)2.37740019
55Retrobulbar optic neuritis (HP:0100654)2.36139800
56Optic neuritis (HP:0100653)2.36139800
57Colon cancer (HP:0003003)2.35241101
58Abnormality of the anterior horn cell (HP:0006802)2.34349105
59Degeneration of anterior horn cells (HP:0002398)2.34349105
60Oral leukoplakia (HP:0002745)2.33256902
61Medial flaring of the eyebrow (HP:0010747)2.31821773
623-Methylglutaconic aciduria (HP:0003535)2.31224683
63Generalized aminoaciduria (HP:0002909)2.28796008
64Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.25881580
65Cerebral hypomyelination (HP:0006808)2.25531317
66Hyperglycinemia (HP:0002154)2.24850403
67Azoospermia (HP:0000027)2.24062017
68Prolonged neonatal jaundice (HP:0006579)2.21584866
69Respiratory failure (HP:0002878)2.20080146
70Myelodysplasia (HP:0002863)2.17334362
71Reduced antithrombin III activity (HP:0001976)2.16723930
72Pancreatic fibrosis (HP:0100732)2.16511998
73Increased intramyocellular lipid droplets (HP:0012240)2.16139631
74Facial cleft (HP:0002006)2.15035942
75Absent thumb (HP:0009777)2.13818128
76Abnormal biliary tract physiology (HP:0012439)2.12410510
77Bile duct proliferation (HP:0001408)2.12410510
78Triphalangeal thumb (HP:0001199)2.12156360
79Exertional dyspnea (HP:0002875)2.11797847
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11446362
81Abnormality of alanine metabolism (HP:0010916)2.11446362
82Hyperalaninemia (HP:0003348)2.11446362
83Aplastic anemia (HP:0001915)2.09976125
84Abnormality of serum amino acid levels (HP:0003112)2.09916867
85Optic disc pallor (HP:0000543)2.08180014
86Sclerocornea (HP:0000647)2.07335028
87Hypoplasia of the pons (HP:0012110)2.06776630
88Ureteral duplication (HP:0000073)2.05853397
89Abnormality of the pons (HP:0007361)2.05742773
90Recurrent abscess formation (HP:0002722)2.05718536
91Aplasia/Hypoplasia involving the musculature (HP:0001460)2.04645131
92Absent hand (HP:0004050)2.03416519
93Duplicated collecting system (HP:0000081)2.01937735
94Pancreatic cysts (HP:0001737)2.01740321
95Aplasia/Hypoplasia of the tongue (HP:0010295)2.01491160
96Increased serum pyruvate (HP:0003542)2.01294166
97Microvesicular hepatic steatosis (HP:0001414)2.00663876
98Lethargy (HP:0001254)1.99896624
99Hypothermia (HP:0002045)1.99538451
100Split foot (HP:0001839)1.98665488
101Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97336639
102Oligodactyly (hands) (HP:0001180)1.97004825
103Abnormal protein glycosylation (HP:0012346)1.96776237
104Abnormal glycosylation (HP:0012345)1.96776237
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96776237
106Abnormal protein N-linked glycosylation (HP:0012347)1.96776237
107Gaze-evoked nystagmus (HP:0000640)1.96577779
108Secondary amenorrhea (HP:0000869)1.95544603
109Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94881006
110Adrenal hypoplasia (HP:0000835)1.94876377
111Ectopic kidney (HP:0000086)1.94334348
112Abnormal lung lobation (HP:0002101)1.93698805
113Abnormality of the renal medulla (HP:0100957)1.93641108
114Sloping forehead (HP:0000340)1.93639327
115Abnormality of the duodenum (HP:0002246)1.92534512
116Horseshoe kidney (HP:0000085)1.92525022
117Granulocytopenia (HP:0001913)1.91502502
118Tracheoesophageal fistula (HP:0002575)1.91072024
119Petechiae (HP:0000967)1.90700738
120Abnormality of cells of the erythroid lineage (HP:0012130)1.90683203
121Abnormality of the labia minora (HP:0012880)1.90582608
122Abnormality of the prostate (HP:0008775)1.90065058
123Premature ovarian failure (HP:0008209)1.89280125
124Short thumb (HP:0009778)1.88797245
125Abnormality of renal resorption (HP:0011038)1.88771029
126Abnormality of the renal cortex (HP:0011035)1.87960399
127Microretrognathia (HP:0000308)1.87136608
128Abnormal number of erythroid precursors (HP:0012131)1.85821044
129Pallor (HP:0000980)1.85692604
130Supernumerary spleens (HP:0009799)1.84993038
131Oligodactyly (HP:0012165)1.84016675
132Oculomotor apraxia (HP:0000657)1.83262744
133Exercise intolerance (HP:0003546)1.82882816
134Abnormality of urine glucose concentration (HP:0011016)1.82834756
135Glycosuria (HP:0003076)1.82834756
136Short tibia (HP:0005736)1.82409576
137Median cleft lip (HP:0000161)1.81912460
138Orchitis (HP:0100796)1.81318722
139Cheilitis (HP:0100825)1.80697099
140Renal cortical cysts (HP:0000803)1.80636048
141Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79410993
142CNS demyelination (HP:0007305)1.79026330
143Congenital primary aphakia (HP:0007707)1.78687308
144Aplasia/Hypoplasia of the tibia (HP:0005772)1.77703026
145Abnormality of methionine metabolism (HP:0010901)1.77668142
146Aplasia/hypoplasia of the uterus (HP:0008684)1.76735992
147Pulmonary fibrosis (HP:0002206)1.76581927
148Abnormality of macular pigmentation (HP:0008002)1.76445314
149Chronic obstructive pulmonary disease (HP:0006510)1.76146692
150Obstructive lung disease (HP:0006536)1.76146692
151Irregular epiphyses (HP:0010582)1.76139870
152Septo-optic dysplasia (HP:0100842)1.74560713
153Abnormality of the renal collecting system (HP:0004742)1.74515413
154Leukodystrophy (HP:0002415)1.72858705
155Abnormality of the vitamin B12 metabolism (HP:0004341)1.72665520
156Capillary hemangiomas (HP:0005306)1.72643197
157Amniotic constriction ring (HP:0009775)1.72612453
158Abnormality of placental membranes (HP:0011409)1.72612453
159Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72553882
160Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72553882
161Agnosia (HP:0010524)1.71464122
162Recurrent bacterial skin infections (HP:0005406)1.71335894
163Hypoplasia of the radius (HP:0002984)1.71183327
164Increased muscle lipid content (HP:0009058)1.70732938
165Chronic hepatic failure (HP:0100626)1.69994604
166Abnormality of vitamin B metabolism (HP:0004340)1.69322093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.14494234
2WEE13.67039456
3PLK43.37474727
4STK163.32633446
5VRK23.12836136
6EIF2AK13.11843690
7SRPK13.02889876
8CDK192.73675960
9ZAK2.66810928
10FRK2.56570231
11NME22.52959150
12IRAK32.46375094
13EIF2AK32.41012096
14AKT32.32549661
15EIF2AK22.10552751
16EPHA22.09112583
17TRIM282.04570867
18MAP4K22.04384214
19MKNK21.92730485
20PIM21.90906599
21VRK11.89565712
22PINK11.88653257
23OXSR11.81869149
24BRSK21.79729022
25TAOK31.79610964
26MKNK11.77415655
27TSSK61.71851560
28PLK11.71377194
29NEK21.61318457
30TXK1.59942207
31WNK31.59491134
32IRAK41.54492512
33PLK31.52728163
34TTK1.48447953
35CDC71.38004060
36BRAF1.37334724
37DYRK31.34517980
38STK38L1.31384232
39ACVR1B1.27863665
40PBK1.24533376
41MAP3K41.19412943
42AURKB1.18856710
43NUAK11.13720796
44ATR1.11063678
45TAF11.08759250
46CCNB11.07645277
47BCKDK1.06004560
48TNIK1.05101481
49MAP3K141.04071599
50CHEK21.02690917
51ARAF1.00274101
52CDK70.98976422
53IKBKB0.98556168
54RPS6KA40.97443377
55BRSK10.94001742
56PIM10.92831346
57PLK20.91589526
58AURKA0.91511362
59BMPR20.91272495
60CDK80.90232939
61TEC0.89729440
62YES10.88907153
63NME10.88595439
64CSNK1G30.88153885
65DYRK20.88040365
66TGFBR10.85142839
67MUSK0.85120779
68STK30.84599505
69INSRR0.84172994
70CSNK1G20.82302623
71CSNK1G10.79895809
72MST40.79096507
73TLK10.76763940
74IRAK10.76709271
75STK240.73675398
76PDK20.73645233
77MAP2K70.70041791
78CSNK2A10.69201816
79RPS6KA50.68900689
80CSNK1A1L0.68291232
81STK390.64914138
82CDK30.61133615
83NEK10.60367599
84STK40.59996845
85GRK10.58598915
86PNCK0.57389292
87BMPR1B0.57042620
88BLK0.56320284
89PASK0.55413268
90LIMK10.55232833
91ADRBK20.55103788
92KDR0.54838780
93ERBB30.54745011
94CHEK10.53670306
95NEK90.53631150
96NLK0.53546571
97CHUK0.53509564
98MAP3K120.49797848
99ABL20.49392864
100MAPK130.48614135
101ATM0.48117397
102TIE10.46913873
103CSNK2A20.46620746
104RPS6KB20.45985800
105NEK60.44082328
106CDK40.42890711
107CDK90.42746561
108PRKCE0.42627882
109PRKCG0.41873056
110WNK40.41086705
111DAPK10.41062888
112LYN0.40349326
113CAMKK20.39990597
114CASK0.39280362
115BCR0.37782446
116CDK20.37112515
117OBSCN0.35586263
118PRKCI0.34344876
119IRAK20.33287656
120CDK10.33035431
121EPHA30.32652453
122PHKG10.31574938
123PHKG20.31574938
124MAP3K80.31441153
125MAPKAPK50.31063382
126JAK30.30036130
127IKBKE0.29852920
128PAK10.29772257
129FLT30.28114309
130KIT0.27657518
131MARK30.27286574
132PRKACB0.27182287
133PRKCD0.26950239
134CSNK1A10.26118674
135PDK40.25677378
136PDK30.25677378
137TNK20.24698983
138CAMK2A0.22782876

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.37236982
2RNA polymerase_Homo sapiens_hsa030204.19777922
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.77857487
4DNA replication_Homo sapiens_hsa030303.31553815
5Homologous recombination_Homo sapiens_hsa034403.13407095
6Pyrimidine metabolism_Homo sapiens_hsa002402.86030640
7Ribosome_Homo sapiens_hsa030102.82125841
8Mismatch repair_Homo sapiens_hsa034302.79653140
9RNA transport_Homo sapiens_hsa030132.65079949
10Spliceosome_Homo sapiens_hsa030402.62321546
11Fanconi anemia pathway_Homo sapiens_hsa034602.51161347
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.42677620
13Basal transcription factors_Homo sapiens_hsa030222.32444974
14Vitamin B6 metabolism_Homo sapiens_hsa007502.30584919
15Base excision repair_Homo sapiens_hsa034102.26663100
16Nucleotide excision repair_Homo sapiens_hsa034202.25341346
17* Cell cycle_Homo sapiens_hsa041101.95524569
18Propanoate metabolism_Homo sapiens_hsa006401.86261924
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81886077
20Alzheimers disease_Homo sapiens_hsa050101.77667483
21Purine metabolism_Homo sapiens_hsa002301.74525334
22Non-homologous end-joining_Homo sapiens_hsa034501.73564643
23RNA degradation_Homo sapiens_hsa030181.72502040
24p53 signaling pathway_Homo sapiens_hsa041151.59702312
25Regulation of autophagy_Homo sapiens_hsa041401.55918028
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.54142651
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41245886
28Selenocompound metabolism_Homo sapiens_hsa004501.40934459
29One carbon pool by folate_Homo sapiens_hsa006701.32780662
30Epstein-Barr virus infection_Homo sapiens_hsa051691.30364736
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22079452
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21866472
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17959840
34Caffeine metabolism_Homo sapiens_hsa002321.16785671
35Graft-versus-host disease_Homo sapiens_hsa053321.15241006
36Allograft rejection_Homo sapiens_hsa053301.14975223
37Butanoate metabolism_Homo sapiens_hsa006501.14920951
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.12948509
39Herpes simplex infection_Homo sapiens_hsa051681.10413364
40Pyruvate metabolism_Homo sapiens_hsa006201.08978370
41mRNA surveillance pathway_Homo sapiens_hsa030151.07055391
42Protein export_Homo sapiens_hsa030601.06467723
43Cardiac muscle contraction_Homo sapiens_hsa042601.04705129
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.02855932
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97865509
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95178737
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94998260
48Fatty acid elongation_Homo sapiens_hsa000620.93639854
49Legionellosis_Homo sapiens_hsa051340.92159248
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91207129
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90841803
52Arachidonic acid metabolism_Homo sapiens_hsa005900.89697774
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87356403
54Huntingtons disease_Homo sapiens_hsa050160.86118855
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85802449
56Peroxisome_Homo sapiens_hsa041460.85577657
57Rheumatoid arthritis_Homo sapiens_hsa053230.84735866
58* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84677441
59Asthma_Homo sapiens_hsa053100.84183144
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.84082028
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83557126
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83481600
63Folate biosynthesis_Homo sapiens_hsa007900.83326571
64Sulfur metabolism_Homo sapiens_hsa009200.79982203
65Autoimmune thyroid disease_Homo sapiens_hsa053200.78493896
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.77339429
67Steroid biosynthesis_Homo sapiens_hsa001000.77247095
68Tryptophan metabolism_Homo sapiens_hsa003800.72797848
69Measles_Homo sapiens_hsa051620.71922399
70Vitamin digestion and absorption_Homo sapiens_hsa049770.71008958
71Oxidative phosphorylation_Homo sapiens_hsa001900.70586841
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68861912
73Nitrogen metabolism_Homo sapiens_hsa009100.66955300
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65038746
75Antigen processing and presentation_Homo sapiens_hsa046120.63860292
76Hematopoietic cell lineage_Homo sapiens_hsa046400.63611659
77Pentose phosphate pathway_Homo sapiens_hsa000300.63315389
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62821866
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61770591
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61383059
81Other glycan degradation_Homo sapiens_hsa005110.61190704
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60936886
83Type I diabetes mellitus_Homo sapiens_hsa049400.60025093
84Chemical carcinogenesis_Homo sapiens_hsa052040.59986040
85Sphingolipid metabolism_Homo sapiens_hsa006000.58422546
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57899723
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57250918
88Parkinsons disease_Homo sapiens_hsa050120.56911964
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56725025
90Systemic lupus erythematosus_Homo sapiens_hsa053220.56337758
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56051762
92Primary immunodeficiency_Homo sapiens_hsa053400.55142737
93Influenza A_Homo sapiens_hsa051640.55127920
94Retinol metabolism_Homo sapiens_hsa008300.51696038
95Leishmaniasis_Homo sapiens_hsa051400.49250452
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.48294815
97Apoptosis_Homo sapiens_hsa042100.48281823
98Olfactory transduction_Homo sapiens_hsa047400.48226418
99Fructose and mannose metabolism_Homo sapiens_hsa000510.47147329
100N-Glycan biosynthesis_Homo sapiens_hsa005100.45989138
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44069021
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43559996
103Viral carcinogenesis_Homo sapiens_hsa052030.42220532
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41854525
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41837995
106* Oocyte meiosis_Homo sapiens_hsa041140.40514104
107Linoleic acid metabolism_Homo sapiens_hsa005910.39982814
108Fatty acid metabolism_Homo sapiens_hsa012120.38671473
109Malaria_Homo sapiens_hsa051440.36700015
110Metabolic pathways_Homo sapiens_hsa011000.36263176
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.35501416
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.35468252
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.35451388
114Circadian rhythm_Homo sapiens_hsa047100.34872391
115Glutathione metabolism_Homo sapiens_hsa004800.34082203
116Phagosome_Homo sapiens_hsa041450.33397418
117beta-Alanine metabolism_Homo sapiens_hsa004100.32842202
118Carbon metabolism_Homo sapiens_hsa012000.32411962
119Shigellosis_Homo sapiens_hsa051310.31213358
120TGF-beta signaling pathway_Homo sapiens_hsa043500.30656847
121Fatty acid degradation_Homo sapiens_hsa000710.30409209
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.30251607
123Pertussis_Homo sapiens_hsa051330.30241221
124* HTLV-I infection_Homo sapiens_hsa051660.30055949
125Nicotine addiction_Homo sapiens_hsa050330.29719169
126Lysosome_Homo sapiens_hsa041420.29649405
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28890620
128Sulfur relay system_Homo sapiens_hsa041220.28711165
129Tuberculosis_Homo sapiens_hsa051520.28358001
130Collecting duct acid secretion_Homo sapiens_hsa049660.26927413
131Hepatitis B_Homo sapiens_hsa051610.26448623
132* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26239275
133Phototransduction_Homo sapiens_hsa047440.25663197
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24583765
135TNF signaling pathway_Homo sapiens_hsa046680.23964509
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23614208
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22394510
138Ether lipid metabolism_Homo sapiens_hsa005650.21823524
139Hedgehog signaling pathway_Homo sapiens_hsa043400.21046674
140Taste transduction_Homo sapiens_hsa047420.19019514
141Small cell lung cancer_Homo sapiens_hsa052220.17540135
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16673582
143Staphylococcus aureus infection_Homo sapiens_hsa051500.14055666
144Mineral absorption_Homo sapiens_hsa049780.13889931
145FoxO signaling pathway_Homo sapiens_hsa040680.13348163

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