ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sequestering of actin monomers (GO:0042989)	6.92725250
2	DNA deamination (GO:0045006)	6.84990822
3	cytidine deamination (GO:0009972)	5.26812297
4	cytidine metabolic process (GO:0046087)	5.26812297
5	cytidine catabolic process (GO:0006216)	5.26812297
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.74424107
7	protein neddylation (GO:0045116)	4.71585357
8	resolution of meiotic recombination intermediates (GO:0000712)	4.63982022
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.62074359
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.51426906
11	neuron fate determination (GO:0048664)	4.23088482
12	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.22566635
13	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.21365338
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.21365338
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.19605058
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.19564763
17	ATP synthesis coupled proton transport (GO:0015986)	4.19564763
18	negative regulation by host of viral transcription (GO:0043922)	4.02473687
19	positive regulation of interleukin-8 secretion (GO:2000484)	4.00289854
20	protein complex biogenesis (GO:0070271)	3.83082767
21	proteasome assembly (GO:0043248)	3.81644968
22	respiratory electron transport chain (GO:0022904)	3.81274133
23	synapsis (GO:0007129)	3.76676722
24	electron transport chain (GO:0022900)	3.74811881
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.74417697
26	NADH dehydrogenase complex assembly (GO:0010257)	3.74417697
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.74417697
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.68089387
29	chaperone-mediated protein transport (GO:0072321)	3.65638102
30	regulation of cellular amino acid metabolic process (GO:0006521)	3.60829036
31	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.59775204
32	cytolysis (GO:0019835)	3.57227123
33	DNA demethylation (GO:0080111)	3.56165401
34	metallo-sulfur cluster assembly (GO:0031163)	3.55724629
35	iron-sulfur cluster assembly (GO:0016226)	3.55724629
36	adaptation of signaling pathway (GO:0023058)	3.46168551
37	GPI anchor biosynthetic process (GO:0006506)	3.41539508
38	male meiosis I (GO:0007141)	3.33892893
39	DNA integration (GO:0015074)	3.33519734
40	aldehyde catabolic process (GO:0046185)	3.26922537
41	GPI anchor metabolic process (GO:0006505)	3.23940802
42	negative regulation of ligase activity (GO:0051352)	3.23859851
43	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.23859851
44	inner mitochondrial membrane organization (GO:0007007)	3.21457949
45	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.20936270
46	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.16612288
47	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.13482540
48	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.09457144
49	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.09320445
50	termination of RNA polymerase III transcription (GO:0006386)	3.09320445
51	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.09063106
52	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.09063106
53	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.09063106
54	DNA dealkylation (GO:0035510)	3.08958279
55	ubiquinone biosynthetic process (GO:0006744)	3.07457363
56	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.04222178
57	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.04222178
58	negative regulation of T cell apoptotic process (GO:0070233)	3.03852105
59	tyrosine phosphorylation of STAT protein (GO:0007260)	3.03330347
60	cullin deneddylation (GO:0010388)	2.99377046
61	ubiquinone metabolic process (GO:0006743)	2.98801924
62	response to redox state (GO:0051775)	2.98640044
63	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.98032589
64	NIK/NF-kappaB signaling (GO:0038061)	2.96567493
65	regulation of interleukin-8 secretion (GO:2000482)	2.95898459
66	adenosine metabolic process (GO:0046085)	2.95471460
67	ribosomal small subunit assembly (GO:0000028)	2.93008524
68	S-adenosylmethionine metabolic process (GO:0046500)	2.92567567
69	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.92416500
70	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.91470322
71	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.91470322
72	protein maturation by protein folding (GO:0022417)	2.91286885
73	regulation of transmission of nerve impulse (GO:0051969)	2.88787430
74	DNA catabolic process, exonucleolytic (GO:0000738)	2.88561675
75	DNA double-strand break processing (GO:0000729)	2.88230453
76	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.86747309
77	purine deoxyribonucleotide catabolic process (GO:0009155)	2.84845722
78	purine nucleobase biosynthetic process (GO:0009113)	2.83265286
79	organelle disassembly (GO:1903008)	2.80428362
80	meiosis I (GO:0007127)	2.78593396
81	positive regulation of ligase activity (GO:0051351)	2.78315731
82	signal peptide processing (GO:0006465)	2.75845329
83	peroxisome fission (GO:0016559)	2.75431288
84	glyoxylate metabolic process (GO:0046487)	2.73905231
85	hydrogen ion transmembrane transport (GO:1902600)	2.71050228
86	pyrimidine nucleoside catabolic process (GO:0046135)	2.70707320
87	regulation of mitochondrial translation (GO:0070129)	2.70581725
88	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.69796647
89	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.69286275
90	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.69286275
91	ncRNA 3-end processing (GO:0043628)	2.67882970
92	purine deoxyribonucleotide metabolic process (GO:0009151)	2.66994467
93	protein targeting to mitochondrion (GO:0006626)	2.66847744
94	protein deneddylation (GO:0000338)	2.64708588
95	histone mRNA metabolic process (GO:0008334)	2.64460627
96	establishment of protein localization to mitochondrion (GO:0072655)	2.60764289
97	purine-containing compound salvage (GO:0043101)	2.59357489
98	cell wall macromolecule catabolic process (GO:0016998)	2.56833211
99	mismatch repair (GO:0006298)	2.55119166
100	protein-cofactor linkage (GO:0018065)	2.54715550

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.65083384
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.28675779
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.28346682
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.25957332
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.75105427
6	VDR_22108803_ChIP-Seq_LS180_Human	3.58178578
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.40303458
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.01464219
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.01106160
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.92514855
11	E2F7_22180533_ChIP-Seq_HELA_Human	2.90577552
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.61857155
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.55242477
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.50936337
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.29197895
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.27851746
17	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.24996843
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.22412661
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.19631783
20	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.19014707
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.13883974
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.96653127
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.89633101
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.84696615
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.80095328
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.69428541
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.68793221
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.66098796
29	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.54070670
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.53506053
31	HTT_18923047_ChIP-ChIP_STHdh_Human	1.50959782
32	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.50087964
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.49662854
34	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.47920070
35	IGF1R_20145208_ChIP-Seq_DFB_Human	1.46831452
36	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.46556834
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.45841319
38	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.39765569
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.39619053
40	DCP1A_22483619_ChIP-Seq_HELA_Human	1.37587440
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.34718611
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33249841
43	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.28756179
44	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.25229252
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.24300123
46	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21572932
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.21011787
48	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20038155
49	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.19940160
50	GABP_19822575_ChIP-Seq_HepG2_Human	1.18686387
51	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.18577937
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18149150
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18149150
54	NCOR_22424771_ChIP-Seq_293T_Human	1.17657241
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.15065269
56	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.14613786
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.13086272
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12842799
59	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12764494
60	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.11567075
61	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.11431650
62	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.10650011
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.06158466
64	TTF2_22483619_ChIP-Seq_HELA_Human	1.05413173
65	FUS_26573619_Chip-Seq_HEK293_Human	1.04664477
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04089332
67	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.04021547
68	ERA_21632823_ChIP-Seq_H3396_Human	1.03607013
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02870431
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02682283
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01379137
72	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.00823271
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00365897
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00365897
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99336346
76	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.99076142
77	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.97372645
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96912878
79	GATA3_26560356_Chip-Seq_TH2_Human	0.96647232
80	RNF2_27304074_Chip-Seq_NSC_Mouse	0.96233184
81	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.95139895
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93423150
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93098516
84	P300_19829295_ChIP-Seq_ESCs_Human	0.92574871
85	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91998935
86	AR_20517297_ChIP-Seq_VCAP_Human	0.91787015
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.91297940
88	TAF2_19829295_ChIP-Seq_ESCs_Human	0.90546374
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90470381
90	EZH2_22144423_ChIP-Seq_EOC_Human	0.90180054
91	XRN2_22483619_ChIP-Seq_HELA_Human	0.88247581
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.87435055
93	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.87106462
94	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.86964613
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86822080
96	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.86213965
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.85949003
98	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.85226260
99	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.85061973
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.85061973

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	3.32663038
2	MP0009333_abnormal_splenocyte_physiolog	2.74601140
3	MP0005084_abnormal_gallbladder_morpholo	2.65701501
4	MP0005671_abnormal_response_to	2.62959548
5	MP0003011_delayed_dark_adaptation	2.54652637
6	MP0003136_yellow_coat_color	2.46823705
7	MP0001968_abnormal_touch/_nociception	2.43618074
8	MP0002736_abnormal_nociception_after	2.33678055
9	MP0003880_abnormal_central_pattern	2.30927843
10	MP0005083_abnormal_biliary_tract	2.27668371
11	MP0002102_abnormal_ear_morphology	2.22492769
12	MP0008058_abnormal_DNA_repair	2.19933210
13	MP0003786_premature_aging	2.17767160
14	MP0002938_white_spotting	2.12411123
15	MP0001501_abnormal_sleep_pattern	2.06775149
16	MP0000372_irregular_coat_pigmentation	2.04007354
17	MP0003806_abnormal_nucleotide_metabolis	1.87523799
18	MP0006292_abnormal_olfactory_placode	1.85089666
19	MP0005645_abnormal_hypothalamus_physiol	1.75832760
20	MP0008789_abnormal_olfactory_epithelium	1.73580444
21	MP0002909_abnormal_adrenal_gland	1.69826415
22	MP0010094_abnormal_chromosome_stability	1.68461380
23	MP0004019_abnormal_vitamin_homeostasis	1.59190434
24	MP0009785_altered_susceptibility_to	1.52642382
25	MP0008877_abnormal_DNA_methylation	1.50991406
26	MP0006035_abnormal_mitochondrial_morpho	1.50506713
27	MP0002163_abnormal_gland_morphology	1.47828645
28	MP0002095_abnormal_skin_pigmentation	1.47756629
29	MP0010030_abnormal_orbit_morphology	1.46983410
30	MP0005551_abnormal_eye_electrophysiolog	1.46368898
31	MP0008872_abnormal_physiological_respon	1.46353640
32	MP0001486_abnormal_startle_reflex	1.45677479
33	MP0005499_abnormal_olfactory_system	1.44133110
34	MP0005394_taste/olfaction_phenotype	1.44133110
35	MP0006036_abnormal_mitochondrial_physio	1.38647138
36	MP0002160_abnormal_reproductive_system	1.38340164
37	MP0006276_abnormal_autonomic_nervous	1.37682544
38	MP0003137_abnormal_impulse_conducting	1.37137820
39	MP0005423_abnormal_somatic_nervous	1.33849323
40	MP0009697_abnormal_copulation	1.33648442
41	MP0004142_abnormal_muscle_tone	1.32874266
42	MP0004043_abnormal_pH_regulation	1.30065567
43	MP0002234_abnormal_pharynx_morphology	1.28588295
44	MP0006082_CNS_inflammation	1.24688345
45	MP0001905_abnormal_dopamine_level	1.20575460
46	MP0000358_abnormal_cell_content/	1.19968694
47	MP0005646_abnormal_pituitary_gland	1.17558472
48	MP0000639_abnormal_adrenal_gland	1.14475145
49	MP0002210_abnormal_sex_determination	1.14256590
50	MP0004145_abnormal_muscle_electrophysio	1.13677868
51	MP0005253_abnormal_eye_physiology	1.11794596
52	MP0001293_anophthalmia	1.08962377
53	MP0001764_abnormal_homeostasis	1.08346650
54	MP0008873_increased_physiological_sensi	1.08083124
55	MP0003186_abnormal_redox_activity	1.04344740
56	MP0005389_reproductive_system_phenotype	1.03618853
57	MP0002733_abnormal_thermal_nociception	1.02722188
58	MP0005075_abnormal_melanosome_morpholog	1.02236604
59	MP0004133_heterotaxia	1.01356906
60	MP0002272_abnormal_nervous_system	1.00404945
61	MP0003638_abnormal_response/metabolism_	0.99911001
62	MP0001881_abnormal_mammary_gland	0.98729984
63	MP0001119_abnormal_female_reproductive	0.97232014
64	MP0003866_abnormal_defecation	0.97054008
65	MP0005379_endocrine/exocrine_gland_phen	0.95939522
66	MP0009046_muscle_twitch	0.93514232
67	MP0005636_abnormal_mineral_homeostasis	0.92119366
68	MP0002928_abnormal_bile_duct	0.90838954
69	MP0001986_abnormal_taste_sensitivity	0.90688633
70	MP0002067_abnormal_sensory_capabilities	0.89061760
71	MP0002277_abnormal_respiratory_mucosa	0.87490404
72	MP0000653_abnormal_sex_gland	0.87254187
73	MP0005408_hypopigmentation	0.86808866
74	MP0009745_abnormal_behavioral_response	0.86347836
75	MP0000647_abnormal_sebaceous_gland	0.85916015
76	MP0003698_abnormal_male_reproductive	0.85289115
77	MP0001984_abnormal_olfaction	0.84825711
78	MP0001929_abnormal_gametogenesis	0.83586359
79	MP0001145_abnormal_male_reproductive	0.81781251
80	MP0001970_abnormal_pain_threshold	0.81759738
81	MP0003718_maternal_effect	0.81191715
82	MP0008007_abnormal_cellular_replicative	0.80447813
83	MP0008875_abnormal_xenobiotic_pharmacok	0.78320521
84	MP0002876_abnormal_thyroid_physiology	0.78007558
85	MP0002132_abnormal_respiratory_system	0.77895856
86	MP0000631_abnormal_neuroendocrine_gland	0.77382540
87	MP0003936_abnormal_reproductive_system	0.77203074
88	MP0001919_abnormal_reproductive_system	0.76927467
89	MP0000703_abnormal_thymus_morphology	0.75906068
90	MP0001346_abnormal_lacrimal_gland	0.75881661
91	MP0003385_abnormal_body_wall	0.75670676
92	MP0002722_abnormal_immune_system	0.74749029
93	MP0003646_muscle_fatigue	0.73809740
94	MP0000749_muscle_degeneration	0.72815850
95	MP0003941_abnormal_skin_development	0.70151620
96	MP0005377_hearing/vestibular/ear_phenot	0.67567134
97	MP0003878_abnormal_ear_physiology	0.67567134
98	MP0006072_abnormal_retinal_apoptosis	0.67563467
99	MP0000427_abnormal_hair_cycle	0.66764177
100	MP0000569_abnormal_digit_pigmentation	0.66663994

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.91759782
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.46733426
3	Mitochondrial inheritance (HP:0001427)	4.38113632
4	Acute encephalopathy (HP:0006846)	4.07561329
5	Progressive macrocephaly (HP:0004481)	3.89312356
6	Increased CSF lactate (HP:0002490)	3.70201252
7	Abnormality of midbrain morphology (HP:0002418)	3.68126408
8	Molar tooth sign on MRI (HP:0002419)	3.68126408
9	Cerebral edema (HP:0002181)	3.39785231
10	Hepatocellular necrosis (HP:0001404)	3.38707733
11	Aplastic anemia (HP:0001915)	3.27023531
12	Hypoplasia of the pons (HP:0012110)	3.22970000
13	Pancreatic cysts (HP:0001737)	3.22410555
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.19625263
15	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.19625263
16	Increased intramyocellular lipid droplets (HP:0012240)	3.10231127
17	Abnormal biliary tract physiology (HP:0012439)	3.03155963
18	Bile duct proliferation (HP:0001408)	3.03155963
19	Hepatic necrosis (HP:0002605)	2.93725869
20	Abnormality of the pons (HP:0007361)	2.91882330
21	Pancreatic fibrosis (HP:0100732)	2.86537634
22	Severe combined immunodeficiency (HP:0004430)	2.72346248
23	Increased hepatocellular lipid droplets (HP:0006565)	2.70731138
24	Optic disc pallor (HP:0000543)	2.62040149
25	Lactic acidosis (HP:0003128)	2.60721303
26	Gait imbalance (HP:0002141)	2.56394734
27	Increased serum lactate (HP:0002151)	2.56320659
28	True hermaphroditism (HP:0010459)	2.55144764
29	Hypomagnesemia (HP:0002917)	2.53972062
30	Abnormality of abdominal situs (HP:0011620)	2.50924232
31	Abdominal situs inversus (HP:0003363)	2.50924232
32	Chromsome breakage (HP:0040012)	2.50347725
33	Congenital primary aphakia (HP:0007707)	2.42567809
34	Exercise intolerance (HP:0003546)	2.42099573
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.41897660
36	Stenosis of the external auditory canal (HP:0000402)	2.41789058
37	Gonadotropin excess (HP:0000837)	2.41278942
38	Medial flaring of the eyebrow (HP:0010747)	2.41269622
39	Increased muscle lipid content (HP:0009058)	2.40375924
40	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.38267315
41	Bifid tongue (HP:0010297)	2.37536311
42	Nephrogenic diabetes insipidus (HP:0009806)	2.36959370
43	Hypothermia (HP:0002045)	2.34852112
44	Lipid accumulation in hepatocytes (HP:0006561)	2.31156901
45	Tetany (HP:0001281)	2.28857593
46	Combined immunodeficiency (HP:0005387)	2.28617449
47	Renal Fanconi syndrome (HP:0001994)	2.27241760
48	Supernumerary spleens (HP:0009799)	2.25335598
49	Abnormal drinking behavior (HP:0030082)	2.25003843
50	Polydipsia (HP:0001959)	2.25003843
51	Respiratory failure (HP:0002878)	2.24228646
52	Oligomenorrhea (HP:0000876)	2.23203362
53	Leukodystrophy (HP:0002415)	2.22058302
54	Abnormality of the anterior horn cell (HP:0006802)	2.21396901
55	Degeneration of anterior horn cells (HP:0002398)	2.21396901
56	Vaginal atresia (HP:0000148)	2.20985586
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20654867
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17890638
59	Genital tract atresia (HP:0001827)	2.16933688
60	Lethargy (HP:0001254)	2.10781224
61	Meckel diverticulum (HP:0002245)	2.10569988
62	Cerebral palsy (HP:0100021)	2.08733448
63	X-linked dominant inheritance (HP:0001423)	2.05159127
64	Tachypnea (HP:0002789)	2.04744376
65	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.04302143
66	Postaxial foot polydactyly (HP:0001830)	2.03866929
67	Cerebral hypomyelination (HP:0006808)	2.02510809
68	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.01233111
69	Hypoproteinemia (HP:0003075)	2.00575013
70	Methylmalonic aciduria (HP:0012120)	2.00208431
71	CNS demyelination (HP:0007305)	1.98951921
72	Abnormality of magnesium homeostasis (HP:0004921)	1.98085683
73	3-Methylglutaconic aciduria (HP:0003535)	1.97975908
74	Respiratory difficulties (HP:0002880)	1.96389995
75	Abnormality of alanine metabolism (HP:0010916)	1.95920482
76	Hyperalaninemia (HP:0003348)	1.95920482
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95920482
78	Exertional dyspnea (HP:0002875)	1.95499956
79	Nephronophthisis (HP:0000090)	1.94814943
80	Concave nail (HP:0001598)	1.93830518
81	Horseshoe kidney (HP:0000085)	1.93749123
82	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.89985796
83	IgG deficiency (HP:0004315)	1.89946838
84	Abnormality of the ileum (HP:0001549)	1.88819656
85	Abnormality of chromosome stability (HP:0003220)	1.87072418
86	Colon cancer (HP:0003003)	1.86130839
87	Type I transferrin isoform profile (HP:0003642)	1.84127706
88	Thyroiditis (HP:0100646)	1.82022158
89	IgM deficiency (HP:0002850)	1.81891782
90	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.79691591
91	Abnormal lung lobation (HP:0002101)	1.79687437
92	Abolished electroretinogram (ERG) (HP:0000550)	1.79664513
93	Preaxial hand polydactyly (HP:0001177)	1.79247673
94	Pancytopenia (HP:0001876)	1.77402803
95	Chronic hepatic failure (HP:0100626)	1.75642676
96	Retinal dysplasia (HP:0007973)	1.75285721
97	Attenuation of retinal blood vessels (HP:0007843)	1.72945577
98	Poor coordination (HP:0002370)	1.71796723
99	Abnormal number of erythroid precursors (HP:0012131)	1.71482015
100	Sclerocornea (HP:0000647)	1.69787528

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.83361802
2	BCKDK	3.56563436
3	PDK2	3.56464832
4	VRK2	3.55550363
5	KDR	3.31821353
6	TESK2	2.85350159
7	MAP4K2	2.49463076
8	BUB1	2.39241935
9	ZAK	2.07993460
10	NME2	2.06145331
11	FRK	1.93010970
12	PNCK	1.86808578
13	VRK1	1.84881796
14	ADRBK2	1.80250624
15	TLK1	1.73073809
16	ACVR1B	1.70906541
17	MAP3K12	1.70079794
18	SRPK1	1.68709518
19	PLK4	1.67420155
20	TAF1	1.63466142
21	LIMK1	1.63301157
22	WNK4	1.51685450
23	TRIM28	1.49863221
24	PIK3CA	1.41963704
25	EIF2AK1	1.40200788
26	TXK	1.40053834
27	DAPK1	1.35264080
28	EIF2AK3	1.33017855
29	NME1	1.32200530
30	PAK3	1.32016144
31	MKNK2	1.27638134
32	EPHA4	1.23783515
33	TNIK	1.20683236
34	PIK3CG	1.14458924
35	MAP3K4	1.12984554
36	PINK1	1.11124696
37	GRK1	1.06548296
38	MKNK1	1.04617680
39	MST4	1.03406658
40	TESK1	1.03323465
41	CAMKK2	0.99597059
42	NUAK1	0.98981029
43	PRKCQ	0.98792571
44	MYLK	0.97128459
45	TTK	0.92558869
46	WNK3	0.91305641
47	BMPR1B	0.87860380
48	KIT	0.84433638
49	GRK7	0.83904188
50	OXSR1	0.83182816
51	TAOK3	0.82266078
52	CSNK1G3	0.77330500
53	ITK	0.77212528
54	STK39	0.76307374
55	ERBB4	0.76290131
56	RIPK4	0.75460021
57	MAP4K1	0.73847904
58	IKBKE	0.73056132
59	TIE1	0.70794902
60	CSNK1G2	0.63858205
61	CSNK1A1L	0.62844873
62	CDK19	0.62572840
63	MAPK13	0.61957670
64	TNK2	0.59898327
65	PIM2	0.57462095
66	OBSCN	0.57347061
67	SYK	0.57241257
68	EIF2AK2	0.56938652
69	PLK3	0.56538948
70	CHEK2	0.56033185
71	CSNK2A1	0.54296659
72	DYRK2	0.51324078
73	CLK1	0.51085927
74	CAMK1	0.50942130
75	ATR	0.50622619
76	LCK	0.50117741
77	CSNK1G1	0.49081484
78	INSRR	0.48634743
79	MAPK15	0.47587481
80	PLK1	0.44969922
81	PRKCI	0.44273817
82	AURKB	0.42321823
83	CAMK2A	0.41829052
84	AURKA	0.41605583
85	CSNK2A2	0.40202524
86	PRKCG	0.40165028
87	PRKCE	0.38937258
88	CAMK1G	0.37572181
89	CSNK1A1	0.35625167
90	PRKACA	0.34254294
91	RPS6KA5	0.33636792
92	MAP2K6	0.30874389
93	PBK	0.30327373
94	MARK1	0.29899186
95	LYN	0.28580346
96	ZAP70	0.27782138
97	PRKCA	0.27520679
98	ABL2	0.26972190
99	DAPK2	0.25743357
100	CDC7	0.25720930

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.51526185
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.76271878
3	Parkinsons disease_Homo sapiens_hsa05012	3.37684189
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.67661825
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.63858668
6	Homologous recombination_Homo sapiens_hsa03440	2.57314142
7	RNA polymerase_Homo sapiens_hsa03020	2.52842045
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.40603939
9	Mismatch repair_Homo sapiens_hsa03430	2.34161883
10	Huntingtons disease_Homo sapiens_hsa05016	2.27597257
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.19051076
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.13867983
13	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.13676482
14	Alzheimers disease_Homo sapiens_hsa05010	2.09652427
15	Ribosome_Homo sapiens_hsa03010	1.97022932
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.93289310
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.93173352
18	DNA replication_Homo sapiens_hsa03030	1.91876839
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.83542916
20	Folate biosynthesis_Homo sapiens_hsa00790	1.71324092
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.67624457
22	Protein export_Homo sapiens_hsa03060	1.60515989
23	Butanoate metabolism_Homo sapiens_hsa00650	1.44656040
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.44224389
25	Propanoate metabolism_Homo sapiens_hsa00640	1.42396863
26	Graft-versus-host disease_Homo sapiens_hsa05332	1.37899131
27	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.27818094
28	Olfactory transduction_Homo sapiens_hsa04740	1.27331678
29	Peroxisome_Homo sapiens_hsa04146	1.25482494
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20999604
31	Base excision repair_Homo sapiens_hsa03410	1.18412156
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18317166
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.15360066
34	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.15307821
35	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.13871592
36	Antigen processing and presentation_Homo sapiens_hsa04612	1.12450264
37	Phototransduction_Homo sapiens_hsa04744	1.09748172
38	Rheumatoid arthritis_Homo sapiens_hsa05323	1.05507007
39	RNA transport_Homo sapiens_hsa03013	1.04936246
40	Selenocompound metabolism_Homo sapiens_hsa00450	1.04928266
41	Purine metabolism_Homo sapiens_hsa00230	1.04426654
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.04297321
43	Basal transcription factors_Homo sapiens_hsa03022	1.00961758
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.00441074
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99914023
46	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.98192810
47	Allograft rejection_Homo sapiens_hsa05330	0.94039058
48	One carbon pool by folate_Homo sapiens_hsa00670	0.93203647
49	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.92909475
50	Caffeine metabolism_Homo sapiens_hsa00232	0.92645583
51	Sulfur relay system_Homo sapiens_hsa04122	0.91323330
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.90974560
53	Fatty acid elongation_Homo sapiens_hsa00062	0.90611827
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90544302
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.88894791
56	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.88424985
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88063659
58	Spliceosome_Homo sapiens_hsa03040	0.87154894
59	Fatty acid metabolism_Homo sapiens_hsa01212	0.86058042
60	Nicotine addiction_Homo sapiens_hsa05033	0.82186996
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.76816452
62	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.76004447
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.74232270
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.71925961
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.71758441
66	Metabolic pathways_Homo sapiens_hsa01100	0.71230477
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.69831466
68	Tryptophan metabolism_Homo sapiens_hsa00380	0.67838750
69	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.67081770
70	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.65750154
71	RNA degradation_Homo sapiens_hsa03018	0.64022483
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.56775613
73	Salmonella infection_Homo sapiens_hsa05132	0.56403117
74	Linoleic acid metabolism_Homo sapiens_hsa00591	0.54396605
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53425481
76	Regulation of autophagy_Homo sapiens_hsa04140	0.52470122
77	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.51641585
78	Glutathione metabolism_Homo sapiens_hsa00480	0.50410137
79	Sulfur metabolism_Homo sapiens_hsa00920	0.49988818
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.49794339
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.45040100
82	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.45016785
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44653746
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43774138
85	Carbon metabolism_Homo sapiens_hsa01200	0.42632459
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.40946447
87	Fatty acid degradation_Homo sapiens_hsa00071	0.40356792
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.38231744
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35146802
90	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.33701301
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31971317
92	Salivary secretion_Homo sapiens_hsa04970	0.29888768
93	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.27071973
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.26988173
95	Renin-angiotensin system_Homo sapiens_hsa04614	0.26798110
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25105166
97	mRNA surveillance pathway_Homo sapiens_hsa03015	0.24817195
98	Cell cycle_Homo sapiens_hsa04110	0.24447090
99	Taste transduction_Homo sapiens_hsa04742	0.22640174
100	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.22219749

ANAPC10P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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