

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.77261404 |
| 2 | DNA deamination (GO:0045006) | 7.38570254 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 6.91876367 |
| 4 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.91876367 |
| 5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 6.17408333 |
| 6 | chaperone-mediated protein transport (GO:0072321) | 6.11697533 |
| 7 | respiratory electron transport chain (GO:0022904) | 5.86991459 |
| 8 | electron transport chain (GO:0022900) | 5.75977108 |
| 9 | proline biosynthetic process (GO:0006561) | 5.40521902 |
| 10 | protein complex biogenesis (GO:0070271) | 5.33160915 |
| 11 | transcription from mitochondrial promoter (GO:0006390) | 5.21823211 |
| 12 | replication fork processing (GO:0031297) | 5.15730759 |
| 13 | mitochondrial respiratory chain complex assembly (GO:0033108) | 5.00301281 |
| 14 | viral mRNA export from host cell nucleus (GO:0046784) | 4.89933639 |
| 15 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.89498080 |
| 16 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.89498080 |
| 17 | NADH dehydrogenase complex assembly (GO:0010257) | 4.89498080 |
| 18 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.89306632 |
| 19 | regulation of mitochondrial translation (GO:0070129) | 4.71449123 |
| 20 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 4.62529918 |
| 21 | proteasome assembly (GO:0043248) | 4.42988425 |
| 22 | viral transcription (GO:0019083) | 4.40469669 |
| 23 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.30168319 |
| 24 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.23669979 |
| 25 | translational termination (GO:0006415) | 4.21695526 |
| 26 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.18422720 |
| 27 | formation of translation preinitiation complex (GO:0001731) | 4.16988806 |
| 28 | cullin deneddylation (GO:0010388) | 4.15476914 |
| 29 | telomere maintenance via recombination (GO:0000722) | 4.10616592 |
| 30 | DNA strand elongation (GO:0022616) | 4.07981066 |
| 31 | protein deneddylation (GO:0000338) | 4.06068142 |
| 32 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 4.03796428 |
| 33 | spliceosomal snRNP assembly (GO:0000387) | 4.02155967 |
| 34 | protein neddylation (GO:0045116) | 3.95154721 |
| 35 | ribosomal small subunit biogenesis (GO:0042274) | 3.94291951 |
| 36 | ribosomal small subunit assembly (GO:0000028) | 3.88789309 |
| 37 | ATP biosynthetic process (GO:0006754) | 3.86562889 |
| 38 | proline metabolic process (GO:0006560) | 3.85119019 |
| 39 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.81308344 |
| 40 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.80475891 |
| 41 | translational initiation (GO:0006413) | 3.78713483 |
| 42 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.78523772 |
| 43 | hydrogen ion transmembrane transport (GO:1902600) | 3.77619299 |
| 44 | GDP-mannose metabolic process (GO:0019673) | 3.76685794 |
| 45 | DNA strand renaturation (GO:0000733) | 3.76678896 |
| 46 | translational elongation (GO:0006414) | 3.76562971 |
| 47 | base-excision repair, AP site formation (GO:0006285) | 3.71016060 |
| 48 | * positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.70952107 |
| 49 | ribosomal large subunit biogenesis (GO:0042273) | 3.70236086 |
| 50 | respiratory chain complex IV assembly (GO:0008535) | 3.69529365 |
| 51 | cytochrome complex assembly (GO:0017004) | 3.69356181 |
| 52 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.68430286 |
| 53 | sequestering of actin monomers (GO:0042989) | 3.67746996 |
| 54 | * regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.67209664 |
| 55 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.67143101 |
| 56 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.67143101 |
| 57 | protein localization to mitochondrion (GO:0070585) | 3.62266578 |
| 58 | cotranslational protein targeting to membrane (GO:0006613) | 3.62188172 |
| 59 | termination of RNA polymerase III transcription (GO:0006386) | 3.61640751 |
| 60 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.61640751 |
| 61 | protein targeting to ER (GO:0045047) | 3.58995246 |
| 62 | inner mitochondrial membrane organization (GO:0007007) | 3.58585487 |
| 63 | rRNA modification (GO:0000154) | 3.57037539 |
| 64 | pseudouridine synthesis (GO:0001522) | 3.56354508 |
| 65 | telomere maintenance via telomere lengthening (GO:0010833) | 3.55152753 |
| 66 | * anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.54915619 |
| 67 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.53121654 |
| 68 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.53121654 |
| 69 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.53121654 |
| 70 | GTP biosynthetic process (GO:0006183) | 3.53066567 |
| 71 | mitotic recombination (GO:0006312) | 3.52941471 |
| 72 | base-excision repair (GO:0006284) | 3.52484785 |
| 73 | mitochondrial DNA metabolic process (GO:0032042) | 3.52307580 |
| 74 | DNA double-strand break processing (GO:0000729) | 3.51106611 |
| 75 | maturation of 5.8S rRNA (GO:0000460) | 3.48677837 |
| 76 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.47557449 |
| 77 | positive regulation of protein homooligomerization (GO:0032464) | 3.46499375 |
| 78 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.45941301 |
| 79 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.45637030 |
| 80 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.45637030 |
| 81 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.45011724 |
| 82 | viral life cycle (GO:0019058) | 3.44881700 |
| 83 | kinetochore assembly (GO:0051382) | 3.44654219 |
| 84 | oxidative demethylation (GO:0070989) | 3.44273886 |
| 85 | spliceosomal complex assembly (GO:0000245) | 3.42660340 |
| 86 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.42549286 |
| 87 | chromatin remodeling at centromere (GO:0031055) | 3.42071876 |
| 88 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.40980192 |
| 89 | maturation of SSU-rRNA (GO:0030490) | 3.40966923 |
| 90 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.39131712 |
| 91 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.39131712 |
| 92 | cellular protein complex disassembly (GO:0043624) | 3.38037207 |
| 93 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.38000783 |
| 94 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.37104954 |
| 95 | protein localization to endoplasmic reticulum (GO:0070972) | 3.36359137 |
| 96 | protein targeting to membrane (GO:0006612) | 3.34834951 |
| 97 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.34256863 |
| 98 | DNA integration (GO:0015074) | 3.33821920 |
| 99 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.32734815 |
| 100 | CENP-A containing nucleosome assembly (GO:0034080) | 3.32644970 |
| 101 | proton transport (GO:0015992) | 3.32017615 |
| 102 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.31579473 |
| 103 | establishment of viral latency (GO:0019043) | 3.29911315 |
| 104 | nuclear envelope reassembly (GO:0031468) | 3.28324619 |
| 105 | mitotic nuclear envelope reassembly (GO:0007084) | 3.28324619 |
| 106 | translation (GO:0006412) | 3.26804255 |
| 107 | rRNA processing (GO:0006364) | 3.26666054 |
| 108 | hydrogen transport (GO:0006818) | 3.24119591 |
| 109 | DNA ligation (GO:0006266) | 3.23883446 |
| 110 | ribosome biogenesis (GO:0042254) | 3.23193701 |
| 111 | * positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.22839247 |
| 112 | protein-cofactor linkage (GO:0018065) | 3.20501788 |
| 113 | DNA replication checkpoint (GO:0000076) | 3.20372044 |
| 114 | oxidative phosphorylation (GO:0006119) | 3.19826932 |
| 115 | mitochondrial transport (GO:0006839) | 3.19780432 |
| 116 | intracellular protein transmembrane import (GO:0044743) | 3.15386494 |
| 117 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.14786731 |
| 118 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.14170330 |
| 119 | rRNA metabolic process (GO:0016072) | 3.13343593 |
| 120 | DNA damage response, detection of DNA damage (GO:0042769) | 3.12227017 |
| 121 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.11178134 |
| 122 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.09457181 |
| 123 | * positive regulation of ligase activity (GO:0051351) | 3.07671043 |
| 124 | UTP biosynthetic process (GO:0006228) | 3.07551023 |
| 125 | termination of RNA polymerase II transcription (GO:0006369) | 3.03756330 |
| 126 | 7-methylguanosine mRNA capping (GO:0006370) | 3.02682895 |
| 127 | embryonic process involved in female pregnancy (GO:0060136) | 3.01848224 |
| 128 | DNA replication initiation (GO:0006270) | 3.00383543 |
| 129 | mitochondrial DNA replication (GO:0006264) | 3.00205135 |
| 130 | negative regulation of cell cycle arrest (GO:0071157) | 3.00103079 |
| 131 | mitochondrial RNA metabolic process (GO:0000959) | 2.98796145 |
| 132 | positive regulation of developmental pigmentation (GO:0048087) | 2.98056281 |
| 133 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.97441906 |
| 134 | protein complex disassembly (GO:0043241) | 2.97373767 |
| 135 | negative regulation of JAK-STAT cascade (GO:0046426) | 2.96437922 |
| 136 | protein targeting to mitochondrion (GO:0006626) | 2.96373462 |
| 137 | * negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.95935697 |
| 138 | cellular component biogenesis (GO:0044085) | 2.93551105 |
| 139 | establishment of protein localization to mitochondrion (GO:0072655) | 2.92543829 |
| 140 | establishment of integrated proviral latency (GO:0075713) | 2.91975223 |
| 141 | kinetochore organization (GO:0051383) | 2.91233469 |
| 142 | * negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.86560372 |
| 143 | * negative regulation of ligase activity (GO:0051352) | 2.86560372 |
| 144 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.84054144 |
| 145 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.82169685 |
| 146 | non-recombinational repair (GO:0000726) | 2.81483820 |
| 147 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.81483820 |
| 148 | macromolecular complex disassembly (GO:0032984) | 2.80676378 |
| 149 | single strand break repair (GO:0000012) | 2.80234472 |
| 150 | deoxyribonucleotide catabolic process (GO:0009264) | 2.79148719 |
| 151 | DNA-templated transcription, termination (GO:0006353) | 2.78961344 |
| 152 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.78893975 |
| 153 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.78242374 |
| 154 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.78242374 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.10969383 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.01503854 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.56387686 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.55268987 |
| 5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.40885318 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.25332459 |
| 7 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.16232401 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.12241481 |
| 9 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.11213620 |
| 10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.07400753 |
| 11 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.92272101 |
| 12 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.77595530 |
| 13 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.70551415 |
| 14 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.70450434 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.55668799 |
| 16 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.53181278 |
| 17 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.49667639 |
| 18 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.38431773 |
| 19 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.35313681 |
| 20 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.28554119 |
| 21 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.28009618 |
| 22 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.27586573 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.20954465 |
| 24 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.20334115 |
| 25 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.09500719 |
| 26 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.05156117 |
| 27 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 2.03609745 |
| 28 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 2.03609745 |
| 29 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 2.03609745 |
| 30 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.02851360 |
| 31 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.99230389 |
| 32 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.96377681 |
| 33 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.91537994 |
| 34 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.86967626 |
| 35 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.85279163 |
| 36 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.78563705 |
| 37 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.78130152 |
| 38 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.77298809 |
| 39 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.75864194 |
| 40 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.75639178 |
| 41 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.74139186 |
| 42 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.70462721 |
| 43 | * KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.69846884 |
| 44 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.69280167 |
| 45 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.68888371 |
| 46 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.67785228 |
| 47 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.67354686 |
| 48 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.66509407 |
| 49 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.64990919 |
| 50 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.61349029 |
| 51 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.55204177 |
| 52 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.52079287 |
| 53 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.50881179 |
| 54 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.49658982 |
| 55 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.49057001 |
| 56 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.48336159 |
| 57 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.46697701 |
| 58 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.46380329 |
| 59 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.43279290 |
| 60 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.41795132 |
| 61 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.38994880 |
| 62 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.37747340 |
| 63 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.36138771 |
| 64 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.35596073 |
| 65 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.34338865 |
| 66 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.30508338 |
| 67 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.29808400 |
| 68 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.28175587 |
| 69 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.27803410 |
| 70 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.27266811 |
| 71 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.26106042 |
| 72 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.25619334 |
| 73 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.25373058 |
| 74 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.24962261 |
| 75 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.23321834 |
| 76 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.21096726 |
| 77 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.20829552 |
| 78 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.20681503 |
| 79 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.19482953 |
| 80 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.19040561 |
| 81 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.18107994 |
| 82 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.17889106 |
| 83 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.17671527 |
| 84 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.17486168 |
| 85 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.16341581 |
| 86 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.16176901 |
| 87 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.15858746 |
| 88 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.15233732 |
| 89 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.13794841 |
| 90 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.13737380 |
| 91 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.12148914 |
| 92 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.10215656 |
| 93 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.10125506 |
| 94 | * MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.07970322 |
| 95 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.07604086 |
| 96 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.05046399 |
| 97 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.04257392 |
| 98 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04163804 |
| 99 | POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 1.03869462 |
| 100 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.03767138 |
| 101 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.03733229 |
| 102 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.03526660 |
| 103 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.03524711 |
| 104 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.01981765 |
| 105 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.01810507 |
| 106 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.01683979 |
| 107 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.00086280 |
| 108 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.99964168 |
| 109 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.99795354 |
| 110 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.98449493 |
| 111 | VDR_22108803_ChIP-Seq_LS180_Human | 0.97301618 |
| 112 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.97281951 |
| 113 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.96540872 |
| 114 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.95203602 |
| 115 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.93588279 |
| 116 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.92049880 |
| 117 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.91969550 |
| 118 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.91768392 |
| 119 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.86204609 |
| 120 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.83775535 |
| 121 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.81859681 |
| 122 | EWS_26573619_Chip-Seq_HEK293_Human | 0.76160993 |
| 123 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.75505996 |
| 124 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.75195757 |
| 125 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.72248903 |
| 126 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.71528856 |
| 127 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.70917416 |
| 128 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.70664681 |
| 129 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.70130199 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 4.37746965 |
| 2 | MP0010030_abnormal_orbit_morphology | 3.45549726 |
| 3 | MP0003693_abnormal_embryo_hatching | 3.39273892 |
| 4 | MP0005171_absent_coat_pigmentation | 3.23484818 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 3.10904837 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 3.08903276 |
| 7 | MP0010094_abnormal_chromosome_stability | 3.06098077 |
| 8 | MP0008932_abnormal_embryonic_tissue | 2.99071256 |
| 9 | MP0008058_abnormal_DNA_repair | 2.72376157 |
| 10 | MP0003186_abnormal_redox_activity | 2.58636002 |
| 11 | MP0003111_abnormal_nucleus_morphology | 2.57446306 |
| 12 | MP0003077_abnormal_cell_cycle | 2.49638720 |
| 13 | MP0003136_yellow_coat_color | 2.42804960 |
| 14 | MP0004133_heterotaxia | 2.42692406 |
| 15 | MP0003786_premature_aging | 2.27098084 |
| 16 | MP0009278_abnormal_bone_marrow | 2.17554157 |
| 17 | MP0006292_abnormal_olfactory_placode | 1.97471211 |
| 18 | MP0002837_dystrophic_cardiac_calcinosis | 1.95578360 |
| 19 | MP0005075_abnormal_melanosome_morpholog | 1.94672162 |
| 20 | MP0002736_abnormal_nociception_after | 1.92131516 |
| 21 | MP0005174_abnormal_tail_pigmentation | 1.90042095 |
| 22 | MP0001986_abnormal_taste_sensitivity | 1.88281360 |
| 23 | MP0002653_abnormal_ependyma_morphology | 1.85120412 |
| 24 | MP0005084_abnormal_gallbladder_morpholo | 1.84792874 |
| 25 | MP0009379_abnormal_foot_pigmentation | 1.80148320 |
| 26 | MP0008877_abnormal_DNA_methylation | 1.77572376 |
| 27 | MP0006072_abnormal_retinal_apoptosis | 1.72824753 |
| 28 | MP0004233_abnormal_muscle_weight | 1.69224321 |
| 29 | MP0006035_abnormal_mitochondrial_morpho | 1.66270701 |
| 30 | MP0003718_maternal_effect | 1.65091059 |
| 31 | MP0003011_delayed_dark_adaptation | 1.63685178 |
| 32 | MP0000490_abnormal_crypts_of | 1.59495206 |
| 33 | MP0008007_abnormal_cellular_replicative | 1.52672383 |
| 34 | MP0002277_abnormal_respiratory_mucosa | 1.47404018 |
| 35 | MP0009333_abnormal_splenocyte_physiolog | 1.44481516 |
| 36 | MP0008995_early_reproductive_senescence | 1.43404162 |
| 37 | MP0002249_abnormal_larynx_morphology | 1.41215509 |
| 38 | MP0002751_abnormal_autonomic_nervous | 1.41035366 |
| 39 | MP0000049_abnormal_middle_ear | 1.39775319 |
| 40 | MP0004142_abnormal_muscle_tone | 1.36476856 |
| 41 | MP0001968_abnormal_touch/_nociception | 1.32923457 |
| 42 | MP0000350_abnormal_cell_proliferation | 1.30322318 |
| 43 | MP0006276_abnormal_autonomic_nervous | 1.29881908 |
| 44 | MP0001293_anophthalmia | 1.27723108 |
| 45 | MP0003121_genomic_imprinting | 1.27660584 |
| 46 | MP0003880_abnormal_central_pattern | 1.27189649 |
| 47 | MP0000015_abnormal_ear_pigmentation | 1.26977990 |
| 48 | MP0001697_abnormal_embryo_size | 1.26588865 |
| 49 | MP0002009_preneoplasia | 1.26399937 |
| 50 | MP0000631_abnormal_neuroendocrine_gland | 1.25374123 |
| 51 | MP0003890_abnormal_embryonic-extraembry | 1.24389841 |
| 52 | MP0002085_abnormal_embryonic_tissue | 1.24132805 |
| 53 | MP0005408_hypopigmentation | 1.21563727 |
| 54 | MP0001188_hyperpigmentation | 1.21400904 |
| 55 | MP0002163_abnormal_gland_morphology | 1.20982007 |
| 56 | MP0001545_abnormal_hematopoietic_system | 1.19176474 |
| 57 | MP0005397_hematopoietic_system_phenotyp | 1.19176474 |
| 58 | MP0002234_abnormal_pharynx_morphology | 1.18377725 |
| 59 | MP0002095_abnormal_skin_pigmentation | 1.16953452 |
| 60 | MP0009697_abnormal_copulation | 1.16739219 |
| 61 | MP0001485_abnormal_pinna_reflex | 1.16712314 |
| 62 | MP0002132_abnormal_respiratory_system | 1.16688062 |
| 63 | MP0003567_abnormal_fetal_cardiomyocyte | 1.14067820 |
| 64 | MP0005646_abnormal_pituitary_gland | 1.13858547 |
| 65 | MP0000313_abnormal_cell_death | 1.12538855 |
| 66 | MP0001730_embryonic_growth_arrest | 1.10653774 |
| 67 | MP0001984_abnormal_olfaction | 1.09727641 |
| 68 | MP0001764_abnormal_homeostasis | 1.08697690 |
| 69 | MP0005253_abnormal_eye_physiology | 1.07962090 |
| 70 | MP0009046_muscle_twitch | 1.06124130 |
| 71 | MP0003122_maternal_imprinting | 1.04689937 |
| 72 | MP0002938_white_spotting | 1.04558359 |
| 73 | MP0001529_abnormal_vocalization | 1.04517403 |
| 74 | MP0001348_abnormal_lacrimal_gland | 1.04303165 |
| 75 | MP0005551_abnormal_eye_electrophysiolog | 1.02942370 |
| 76 | MP0005645_abnormal_hypothalamus_physiol | 1.02757396 |
| 77 | MP0003123_paternal_imprinting | 1.01951956 |
| 78 | MP0003119_abnormal_digestive_system | 1.00519089 |
| 79 | MP0000762_abnormal_tongue_morphology | 1.00229135 |
| 80 | MP0002084_abnormal_developmental_patter | 0.99770600 |
| 81 | MP0002080_prenatal_lethality | 0.98337301 |
| 82 | MP0000026_abnormal_inner_ear | 0.97638378 |
| 83 | MP0002019_abnormal_tumor_incidence | 0.96807937 |
| 84 | MP0008789_abnormal_olfactory_epithelium | 0.96807212 |
| 85 | MP0000566_synostosis | 0.95711376 |
| 86 | MP0008875_abnormal_xenobiotic_pharmacok | 0.95342337 |
| 87 | MP0005380_embryogenesis_phenotype | 0.94983223 |
| 88 | MP0001672_abnormal_embryogenesis/_devel | 0.94983223 |
| 89 | MP0005377_hearing/vestibular/ear_phenot | 0.93782974 |
| 90 | MP0003878_abnormal_ear_physiology | 0.93782974 |
| 91 | MP0002210_abnormal_sex_determination | 0.91626682 |
| 92 | MP0002111_abnormal_tail_morphology | 0.91403972 |
| 93 | MP0008872_abnormal_physiological_respon | 0.90307638 |
| 94 | MP0003315_abnormal_perineum_morphology | 0.89782797 |
| 95 | MP0001145_abnormal_male_reproductive | 0.88934993 |
| 96 | MP0002114_abnormal_axial_skeleton | 0.85191572 |
| 97 | MP0005389_reproductive_system_phenotype | 0.85127693 |
| 98 | MP0002282_abnormal_trachea_morphology | 0.84719271 |
| 99 | MP0002932_abnormal_joint_morphology | 0.84609370 |
| 100 | MP0002233_abnormal_nose_morphology | 0.83472338 |
| 101 | MP0004145_abnormal_muscle_electrophysio | 0.83412466 |
| 102 | MP0003755_abnormal_palate_morphology | 0.82413526 |
| 103 | MP0003646_muscle_fatigue | 0.82066657 |
| 104 | MP0005332_abnormal_amino_acid | 0.81560137 |
| 105 | MP0000462_abnormal_digestive_system | 0.81226822 |
| 106 | MP0002116_abnormal_craniofacial_bone | 0.81102404 |
| 107 | MP0000470_abnormal_stomach_morphology | 0.80989140 |
| 108 | MP0003937_abnormal_limbs/digits/tail_de | 0.80828261 |
| 109 | MP0003656_abnormal_erythrocyte_physiolo | 0.80621781 |
| 110 | MP0002272_abnormal_nervous_system | 0.80375636 |
| 111 | MP0001286_abnormal_eye_development | 0.79310398 |
| 112 | MP0005195_abnormal_posterior_eye | 0.78992131 |
| 113 | MP0002396_abnormal_hematopoietic_system | 0.78773201 |
| 114 | MP0002752_abnormal_somatic_nervous | 0.77470340 |
| 115 | MP0004742_abnormal_vestibular_system | 0.76982010 |
| 116 | MP0009745_abnormal_behavioral_response | 0.76873519 |
| 117 | MP0000749_muscle_degeneration | 0.76865249 |
| 118 | MP0002822_catalepsy | 0.75751267 |
| 119 | MP0005391_vision/eye_phenotype | 0.74741177 |
| 120 | MP0003283_abnormal_digestive_organ | 0.74701304 |
| 121 | MP0001919_abnormal_reproductive_system | 0.74305747 |
| 122 | MP0003137_abnormal_impulse_conducting | 0.73950854 |
| 123 | MP0000678_abnormal_parathyroid_gland | 0.73348793 |
| 124 | MP0001346_abnormal_lacrimal_gland | 0.72431796 |
| 125 | MP0002876_abnormal_thyroid_physiology | 0.71970270 |
| 126 | MP0000778_abnormal_nervous_system | 0.71492093 |
| 127 | MP0000358_abnormal_cell_content/ | 0.71409141 |
| 128 | MP0002086_abnormal_extraembryonic_tissu | 0.70665122 |
| 129 | MP0003984_embryonic_growth_retardation | 0.70326855 |
| 130 | MP0001929_abnormal_gametogenesis | 0.69905363 |
| 131 | MP0002127_abnormal_cardiovascular_syste | 0.68683202 |
| 132 | MP0003938_abnormal_ear_development | 0.68640887 |
| 133 | MP0002638_abnormal_pupillary_reflex | 0.68607172 |
| 134 | MP0004147_increased_porphyrin_level | 0.67964575 |
| 135 | MP0002160_abnormal_reproductive_system | 0.67500038 |
| 136 | MP0003385_abnormal_body_wall | 0.66829036 |
| 137 | MP0002102_abnormal_ear_morphology | 0.65817781 |
| 138 | MP0001905_abnormal_dopamine_level | 0.65103277 |
| 139 | MP0000653_abnormal_sex_gland | 0.65022604 |
| 140 | MP0006036_abnormal_mitochondrial_physio | 0.64986456 |
| 141 | MP0002075_abnormal_coat/hair_pigmentati | 0.64933894 |
| 142 | MP0002088_abnormal_embryonic_growth/wei | 0.64929208 |
| 143 | MP0003950_abnormal_plasma_membrane | 0.64610473 |
| 144 | MP0004197_abnormal_fetal_growth/weight/ | 0.64386162 |
| 145 | MP0003763_abnormal_thymus_physiology | 0.61818663 |
| 146 | MP0000372_irregular_coat_pigmentation | 0.60704359 |
| 147 | MP0000689_abnormal_spleen_morphology | 0.60339924 |
| 148 | MP0000681_abnormal_thyroid_gland | 0.59437568 |
| 149 | MP0005394_taste/olfaction_phenotype | 0.59395634 |
| 150 | MP0005499_abnormal_olfactory_system | 0.59395634 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Concave nail (HP:0001598) | 4.47343003 |
| 2 | Lipid accumulation in hepatocytes (HP:0006561) | 4.39592426 |
| 3 | Renal Fanconi syndrome (HP:0001994) | 4.26748837 |
| 4 | Cerebral edema (HP:0002181) | 4.12469456 |
| 5 | Cerebral hypomyelination (HP:0006808) | 3.79751642 |
| 6 | Increased intramyocellular lipid droplets (HP:0012240) | 3.79109609 |
| 7 | Rib fusion (HP:0000902) | 3.59667751 |
| 8 | Rectal fistula (HP:0100590) | 3.49150019 |
| 9 | Rectovaginal fistula (HP:0000143) | 3.49150019 |
| 10 | Tongue fasciculations (HP:0001308) | 3.49036586 |
| 11 | Reticulocytopenia (HP:0001896) | 3.42705206 |
| 12 | Increased IgM level (HP:0003496) | 3.41536072 |
| 13 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.40726908 |
| 14 | Lactic acidosis (HP:0003128) | 3.32161200 |
| 15 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 3.31284820 |
| 16 | Acute necrotizing encephalopathy (HP:0006965) | 3.26208959 |
| 17 | Increased muscle lipid content (HP:0009058) | 3.20422650 |
| 18 | Absent radius (HP:0003974) | 3.18159705 |
| 19 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.13382752 |
| 20 | Selective tooth agenesis (HP:0001592) | 3.12420971 |
| 21 | Muscle fibrillation (HP:0010546) | 3.08914210 |
| 22 | Breast hypoplasia (HP:0003187) | 3.04007992 |
| 23 | Abnormal hemoglobin (HP:0011902) | 3.03725310 |
| 24 | Patellar aplasia (HP:0006443) | 2.99530567 |
| 25 | Absent forearm bone (HP:0003953) | 2.98819031 |
| 26 | Aplasia involving forearm bones (HP:0009822) | 2.98819031 |
| 27 | Optic disc pallor (HP:0000543) | 2.97471040 |
| 28 | Absent thumb (HP:0009777) | 2.97424628 |
| 29 | Premature graying of hair (HP:0002216) | 2.97184654 |
| 30 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.96861927 |
| 31 | Abnormal number of erythroid precursors (HP:0012131) | 2.96335778 |
| 32 | Exertional dyspnea (HP:0002875) | 2.96135302 |
| 33 | Hepatocellular necrosis (HP:0001404) | 2.95491532 |
| 34 | Mitochondrial inheritance (HP:0001427) | 2.92875929 |
| 35 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.91242833 |
| 36 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.91242833 |
| 37 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.85341407 |
| 38 | Intestinal fistula (HP:0100819) | 2.80246601 |
| 39 | Vaginal fistula (HP:0004320) | 2.77744345 |
| 40 | Abnormality of the ileum (HP:0001549) | 2.73451343 |
| 41 | Supernumerary spleens (HP:0009799) | 2.72642396 |
| 42 | Respiratory difficulties (HP:0002880) | 2.62378229 |
| 43 | Methylmalonic aciduria (HP:0012120) | 2.56522244 |
| 44 | Congenital, generalized hypertrichosis (HP:0004540) | 2.54072744 |
| 45 | Lethargy (HP:0001254) | 2.52078699 |
| 46 | Abnormality of renal resorption (HP:0011038) | 2.51531066 |
| 47 | Methylmalonic acidemia (HP:0002912) | 2.48587543 |
| 48 | Increased CSF lactate (HP:0002490) | 2.44776000 |
| 49 | Intestinal atresia (HP:0011100) | 2.44700616 |
| 50 | Birth length less than 3rd percentile (HP:0003561) | 2.42382951 |
| 51 | Facial hemangioma (HP:0000329) | 2.39566595 |
| 52 | Colon cancer (HP:0003003) | 2.39558959 |
| 53 | Hypoplasia of the radius (HP:0002984) | 2.38145491 |
| 54 | Coronal craniosynostosis (HP:0004440) | 2.32948080 |
| 55 | Macrocytic anemia (HP:0001972) | 2.32692199 |
| 56 | Acute encephalopathy (HP:0006846) | 2.31081673 |
| 57 | Generalized aminoaciduria (HP:0002909) | 2.30135259 |
| 58 | Muscle fiber atrophy (HP:0100295) | 2.29495976 |
| 59 | Abnormal number of incisors (HP:0011064) | 2.28093704 |
| 60 | Increased serum lactate (HP:0002151) | 2.28004875 |
| 61 | Annular pancreas (HP:0001734) | 2.27691086 |
| 62 | Pancreatic fibrosis (HP:0100732) | 2.27122919 |
| 63 | X-linked dominant inheritance (HP:0001423) | 2.26854173 |
| 64 | Progressive macrocephaly (HP:0004481) | 2.26650661 |
| 65 | Pallor (HP:0000980) | 2.26153011 |
| 66 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.25735288 |
| 67 | Rough bone trabeculation (HP:0100670) | 2.25144380 |
| 68 | Type I transferrin isoform profile (HP:0003642) | 2.25007625 |
| 69 | Abnormality of the labia minora (HP:0012880) | 2.24898641 |
| 70 | Pancreatic cysts (HP:0001737) | 2.24734284 |
| 71 | Poikiloderma (HP:0001029) | 2.24651508 |
| 72 | Glycosuria (HP:0003076) | 2.24442795 |
| 73 | Abnormality of urine glucose concentration (HP:0011016) | 2.24442795 |
| 74 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.23205788 |
| 75 | Hyperglycinemia (HP:0002154) | 2.21794764 |
| 76 | CNS demyelination (HP:0007305) | 2.21599479 |
| 77 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.21527454 |
| 78 | Hepatic necrosis (HP:0002605) | 2.21454739 |
| 79 | Redundant skin (HP:0001582) | 2.21367505 |
| 80 | Orthostatic hypotension (HP:0001278) | 2.19820464 |
| 81 | Alacrima (HP:0000522) | 2.18138360 |
| 82 | Abnormality of midbrain morphology (HP:0002418) | 2.13177173 |
| 83 | Molar tooth sign on MRI (HP:0002419) | 2.13177173 |
| 84 | Exercise intolerance (HP:0003546) | 2.12619129 |
| 85 | Meckel diverticulum (HP:0002245) | 2.10814367 |
| 86 | Increased serum pyruvate (HP:0003542) | 2.07666265 |
| 87 | Abnormality of the aortic arch (HP:0012303) | 2.06990090 |
| 88 | Hyperphosphaturia (HP:0003109) | 2.06616882 |
| 89 | Abnormal protein glycosylation (HP:0012346) | 2.05481524 |
| 90 | Abnormal glycosylation (HP:0012345) | 2.05481524 |
| 91 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.05481524 |
| 92 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.05481524 |
| 93 | Type 2 muscle fiber atrophy (HP:0003554) | 2.04891230 |
| 94 | Respiratory failure (HP:0002878) | 2.04833246 |
| 95 | Dysautonomia (HP:0002459) | 2.03491993 |
| 96 | True hermaphroditism (HP:0010459) | 2.03212215 |
| 97 | Septo-optic dysplasia (HP:0100842) | 2.03198638 |
| 98 | Hypokinesia (HP:0002375) | 2.02974149 |
| 99 | Sclerocornea (HP:0000647) | 2.02413166 |
| 100 | Myokymia (HP:0002411) | 2.01772549 |
| 101 | Albinism (HP:0001022) | 2.01193000 |
| 102 | Pancytopenia (HP:0001876) | 2.01141232 |
| 103 | Broad alveolar ridges (HP:0000187) | 2.00020225 |
| 104 | Asplenia (HP:0001746) | 1.98797788 |
| 105 | Oral leukoplakia (HP:0002745) | 1.97729663 |
| 106 | Trismus (HP:0000211) | 1.97279833 |
| 107 | 3-Methylglutaconic aciduria (HP:0003535) | 1.96435242 |
| 108 | Diaphragmatic weakness (HP:0009113) | 1.94866669 |
| 109 | Pustule (HP:0200039) | 1.94490632 |
| 110 | Duplicated collecting system (HP:0000081) | 1.93284264 |
| 111 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.92026376 |
| 112 | Dicarboxylic aciduria (HP:0003215) | 1.92026376 |
| 113 | Emotional lability (HP:0000712) | 1.91706682 |
| 114 | Medial flaring of the eyebrow (HP:0010747) | 1.90997467 |
| 115 | Carpal bone hypoplasia (HP:0001498) | 1.90932648 |
| 116 | Abnormality of male internal genitalia (HP:0000022) | 1.89550764 |
| 117 | Triphalangeal thumb (HP:0001199) | 1.88456877 |
| 118 | Abnormality of the preputium (HP:0100587) | 1.88355685 |
| 119 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.87601318 |
| 120 | Degeneration of anterior horn cells (HP:0002398) | 1.87517145 |
| 121 | Abnormality of the anterior horn cell (HP:0006802) | 1.87517145 |
| 122 | Squamous cell carcinoma (HP:0002860) | 1.87197824 |
| 123 | Abdominal situs inversus (HP:0003363) | 1.85699960 |
| 124 | Abnormality of abdominal situs (HP:0011620) | 1.85699960 |
| 125 | Increased hepatocellular lipid droplets (HP:0006565) | 1.84738751 |
| 126 | Abnormality of alanine metabolism (HP:0010916) | 1.84109817 |
| 127 | Hyperalaninemia (HP:0003348) | 1.84109817 |
| 128 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.84109817 |
| 129 | Premature skin wrinkling (HP:0100678) | 1.84065206 |
| 130 | Aplasia of the musculature (HP:0100854) | 1.83846216 |
| 131 | Microvesicular hepatic steatosis (HP:0001414) | 1.82127863 |
| 132 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.79365747 |
| 133 | Hypoplasia of the pons (HP:0012110) | 1.79365267 |
| 134 | Aplastic anemia (HP:0001915) | 1.79027590 |
| 135 | Leukodystrophy (HP:0002415) | 1.78871506 |
| 136 | Abnormality of glycolysis (HP:0004366) | 1.78659935 |
| 137 | Decreased lacrimation (HP:0000633) | 1.78014635 |
| 138 | Aplasia/Hypoplasia of the vertebrae (HP:0008515) | 1.77742823 |
| 139 | Vertebral hypoplasia (HP:0008417) | 1.77742823 |
| 140 | Congenital stationary night blindness (HP:0007642) | 1.76750409 |
| 141 | Abnormality of placental membranes (HP:0011409) | 1.76372515 |
| 142 | Amniotic constriction ring (HP:0009775) | 1.76372515 |
| 143 | Delayed CNS myelination (HP:0002188) | 1.76180461 |
| 144 | Absent septum pellucidum (HP:0001331) | 1.75742586 |
| 145 | Blindness (HP:0000618) | 1.75562757 |
| 146 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.75031110 |
| 147 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.73635140 |
| 148 | Poor suck (HP:0002033) | 1.72133409 |
| 149 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.68917611 |
| 150 | Testicular atrophy (HP:0000029) | 1.68685526 |
| 151 | Pendular nystagmus (HP:0012043) | 1.66416986 |
| 152 | Hypoplastic pelvis (HP:0008839) | 1.65368363 |
| 153 | Abnormality of serum amino acid levels (HP:0003112) | 1.64989600 |
| 154 | Reduced antithrombin III activity (HP:0001976) | 1.63663121 |
| 155 | Abnormality of the pons (HP:0007361) | 1.63014398 |
| 156 | Sparse eyelashes (HP:0000653) | 1.62838272 |
| 157 | Cleft eyelid (HP:0000625) | 1.62744720 |
| 158 | Short tibia (HP:0005736) | 1.61241578 |
| 159 | Progressive microcephaly (HP:0000253) | 1.59749990 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.87417876 |
| 2 | BUB1 | 3.81852570 |
| 3 | TLK1 | 3.38749493 |
| 4 | MAPK15 | 3.24370598 |
| 5 | MAP3K11 | 3.14650006 |
| 6 | ICK | 3.09923466 |
| 7 | PIM2 | 3.08283534 |
| 8 | TESK2 | 2.96617548 |
| 9 | NME2 | 2.65102809 |
| 10 | BCKDK | 2.50375419 |
| 11 | DDR2 | 2.38888382 |
| 12 | MATK | 2.36752092 |
| 13 | WEE1 | 2.32980979 |
| 14 | UHMK1 | 2.32922696 |
| 15 | MAP3K6 | 2.32189792 |
| 16 | EIF2AK1 | 2.06687121 |
| 17 | PINK1 | 1.94223946 |
| 18 | STK16 | 1.83745638 |
| 19 | NUAK1 | 1.82371099 |
| 20 | YES1 | 1.79589563 |
| 21 | CDK7 | 1.77959960 |
| 22 | SRPK1 | 1.65198567 |
| 23 | WNK3 | 1.58074953 |
| 24 | DAPK1 | 1.54789392 |
| 25 | VRK1 | 1.48901400 |
| 26 | PLK1 | 1.45302111 |
| 27 | MAP4K2 | 1.41966940 |
| 28 | LIMK1 | 1.40097341 |
| 29 | PLK3 | 1.40016128 |
| 30 | PDK2 | 1.36311092 |
| 31 | BMPR1B | 1.34959828 |
| 32 | CDC7 | 1.29598242 |
| 33 | DYRK2 | 1.29265465 |
| 34 | ARAF | 1.29218979 |
| 35 | EPHB2 | 1.27224198 |
| 36 | FGR | 1.25624654 |
| 37 | DYRK3 | 1.24132162 |
| 38 | NME1 | 1.21472816 |
| 39 | ABL2 | 1.19865967 |
| 40 | CDK19 | 1.19626644 |
| 41 | ADRBK2 | 1.19392931 |
| 42 | TESK1 | 1.19288309 |
| 43 | MKNK2 | 1.19202305 |
| 44 | LATS2 | 1.18927165 |
| 45 | PRKD2 | 1.18702797 |
| 46 | AURKA | 1.18148668 |
| 47 | MAP2K7 | 1.18134884 |
| 48 | CSNK1G3 | 1.17125395 |
| 49 | PBK | 1.16897775 |
| 50 | CHEK2 | 1.14907830 |
| 51 | TAF1 | 1.12995374 |
| 52 | MKNK1 | 1.07321762 |
| 53 | MUSK | 1.04725199 |
| 54 | TTK | 1.04375817 |
| 55 | CDK8 | 1.03960437 |
| 56 | CSNK1G2 | 1.01501292 |
| 57 | PRPF4B | 1.00967166 |
| 58 | PIM1 | 1.00627333 |
| 59 | BLK | 0.99446158 |
| 60 | CSK | 0.99321477 |
| 61 | CSNK1G1 | 0.96537477 |
| 62 | CASK | 0.93683861 |
| 63 | GRK1 | 0.90162337 |
| 64 | DYRK1B | 0.88639821 |
| 65 | PAK1 | 0.87198277 |
| 66 | PLK4 | 0.84519050 |
| 67 | AKT3 | 0.83412832 |
| 68 | RPS6KC1 | 0.82402535 |
| 69 | RPS6KL1 | 0.82402535 |
| 70 | BMX | 0.81012305 |
| 71 | RPS6KB2 | 0.80066960 |
| 72 | ATR | 0.79150084 |
| 73 | CCNB1 | 0.76465088 |
| 74 | MST4 | 0.75201769 |
| 75 | CSNK1A1L | 0.74778524 |
| 76 | STK3 | 0.73756081 |
| 77 | RPS6KA6 | 0.73323071 |
| 78 | TRIM28 | 0.73038898 |
| 79 | AURKB | 0.72824432 |
| 80 | CSNK2A1 | 0.72551963 |
| 81 | BRSK2 | 0.69286143 |
| 82 | INSRR | 0.66898729 |
| 83 | PRKCG | 0.66542333 |
| 84 | TYRO3 | 0.65523179 |
| 85 | DAPK3 | 0.65392653 |
| 86 | NEK2 | 0.64540047 |
| 87 | PRKCI | 0.63884591 |
| 88 | ILK | 0.63213163 |
| 89 | LRRK2 | 0.58891821 |
| 90 | PHKG2 | 0.58033121 |
| 91 | PHKG1 | 0.58033121 |
| 92 | BRAF | 0.57574276 |
| 93 | CDK11A | 0.57573893 |
| 94 | TSSK6 | 0.57508892 |
| 95 | MYLK | 0.56802223 |
| 96 | CDK14 | 0.56571523 |
| 97 | CSNK2A2 | 0.55054220 |
| 98 | CLK1 | 0.55053597 |
| 99 | KDR | 0.54894017 |
| 100 | STK24 | 0.53010874 |
| 101 | TAOK2 | 0.52778064 |
| 102 | CDK15 | 0.51970054 |
| 103 | STK4 | 0.51809514 |
| 104 | EIF2AK3 | 0.51771297 |
| 105 | BRSK1 | 0.51677901 |
| 106 | CDK18 | 0.51366787 |
| 107 | MAP3K12 | 0.50849883 |
| 108 | PLK2 | 0.50773921 |
| 109 | CDC42BPA | 0.49256847 |
| 110 | MAPKAPK5 | 0.48409370 |
| 111 | MAP3K8 | 0.47617957 |
| 112 | NEK1 | 0.47419370 |
| 113 | MINK1 | 0.47288920 |
| 114 | MAPK13 | 0.47051537 |
| 115 | PASK | 0.46910451 |
| 116 | WNK4 | 0.45494160 |
| 117 | CAMK2B | 0.45137419 |
| 118 | CDK2 | 0.44056716 |
| 119 | TNIK | 0.44050875 |
| 120 | CAMK2D | 0.43367465 |
| 121 | MAP2K2 | 0.43064354 |
| 122 | PNCK | 0.42821727 |
| 123 | OXSR1 | 0.42687951 |
| 124 | ADRBK1 | 0.42680268 |
| 125 | IKBKB | 0.42550709 |
| 126 | CSNK1A1 | 0.41648176 |
| 127 | STK10 | 0.41644655 |
| 128 | RPS6KA5 | 0.41145647 |
| 129 | PAK4 | 0.40668425 |
| 130 | LYN | 0.39942119 |
| 131 | OBSCN | 0.39771526 |
| 132 | CAMK2G | 0.39264472 |
| 133 | CHEK1 | 0.38837236 |
| 134 | ZAK | 0.38791005 |
| 135 | PKN1 | 0.38611685 |
| 136 | TRPM7 | 0.37913130 |
| 137 | EPHA2 | 0.36766075 |
| 138 | TIE1 | 0.35822068 |
| 139 | BCR | 0.35202468 |
| 140 | GRK7 | 0.34494408 |
| 141 | GRK5 | 0.33819799 |
| 142 | RPS6KA1 | 0.33579693 |
| 143 | PRKACA | 0.32742486 |
| 144 | MAP3K4 | 0.32525949 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.42992645 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.36263754 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 4.32839402 |
| 4 | Base excision repair_Homo sapiens_hsa03410 | 3.65367896 |
| 5 | Proteasome_Homo sapiens_hsa03050 | 3.38374009 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.37163466 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 3.13510754 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 3.02250399 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.86405172 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.75412463 |
| 11 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.52382994 |
| 12 | Parkinsons disease_Homo sapiens_hsa05012 | 2.38315116 |
| 13 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.37319980 |
| 14 | RNA transport_Homo sapiens_hsa03013 | 2.21010902 |
| 15 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.10943233 |
| 16 | Huntingtons disease_Homo sapiens_hsa05016 | 1.91512637 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.80284351 |
| 18 | * Cell cycle_Homo sapiens_hsa04110 | 1.72415669 |
| 19 | Sulfur relay system_Homo sapiens_hsa04122 | 1.42248683 |
| 20 | Alzheimers disease_Homo sapiens_hsa05010 | 1.41087838 |
| 21 | Protein export_Homo sapiens_hsa03060 | 1.39363582 |
| 22 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.33754752 |
| 23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.33548380 |
| 24 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.31858829 |
| 25 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.30566814 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.29345534 |
| 27 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.27622695 |
| 28 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.27522891 |
| 29 | RNA degradation_Homo sapiens_hsa03018 | 1.26669625 |
| 30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.24143276 |
| 31 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.21656306 |
| 32 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.16289934 |
| 33 | Purine metabolism_Homo sapiens_hsa00230 | 1.12287039 |
| 34 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.09543651 |
| 35 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.06725342 |
| 36 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.03537627 |
| 37 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.01424433 |
| 38 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.98123293 |
| 39 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.90851988 |
| 40 | Phototransduction_Homo sapiens_hsa04744 | 0.89383944 |
| 41 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.88373089 |
| 42 | Peroxisome_Homo sapiens_hsa04146 | 0.87686933 |
| 43 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.87584404 |
| 44 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.86482177 |
| 45 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.85949495 |
| 46 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.84767615 |
| 47 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.83245118 |
| 48 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.82564994 |
| 49 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.82425049 |
| 50 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.72366896 |
| 51 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.70764345 |
| 52 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.69928268 |
| 53 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.69778013 |
| 54 | Shigellosis_Homo sapiens_hsa05131 | 0.67817815 |
| 55 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.66678568 |
| 56 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.63574768 |
| 57 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.61684410 |
| 58 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.59266653 |
| 59 | Carbon metabolism_Homo sapiens_hsa01200 | 0.58817145 |
| 60 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.58651967 |
| 61 | * Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.56947980 |
| 62 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.56533729 |
| 63 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.55431218 |
| 64 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.53190981 |
| 65 | * Oocyte meiosis_Homo sapiens_hsa04114 | 0.52376560 |
| 66 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.50397504 |
| 67 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.50129944 |
| 68 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.49622580 |
| 69 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.49545966 |
| 70 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.49250908 |
| 71 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.48629134 |
| 72 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.48315528 |
| 73 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.47982492 |
| 74 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.47566192 |
| 75 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.47500879 |
| 76 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.47413410 |
| 77 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.47364941 |
| 78 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.47325632 |
| 79 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.47016511 |
| 80 | Bladder cancer_Homo sapiens_hsa05219 | 0.45806253 |
| 81 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.45451839 |
| 82 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.44670954 |
| 83 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.43873979 |
| 84 | Legionellosis_Homo sapiens_hsa05134 | 0.43802784 |
| 85 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.43612734 |
| 86 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.41940592 |
| 87 | Metabolic pathways_Homo sapiens_hsa01100 | 0.39573424 |
| 88 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.38420528 |
| 89 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.37039215 |
| 90 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.35951530 |
| 91 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.33276087 |
| 92 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.32009261 |
| 93 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.30922061 |
| 94 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.30851114 |
| 95 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.29730124 |
| 96 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.29303164 |
| 97 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.29147086 |
| 98 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.27562160 |
| 99 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.27488720 |
| 100 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.26960461 |
| 101 | Retinol metabolism_Homo sapiens_hsa00830 | 0.26699677 |
| 102 | Colorectal cancer_Homo sapiens_hsa05210 | 0.26362350 |
| 103 | Galactose metabolism_Homo sapiens_hsa00052 | 0.25960335 |
| 104 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.25920268 |
| 105 | Allograft rejection_Homo sapiens_hsa05330 | 0.25890690 |
| 106 | Viral myocarditis_Homo sapiens_hsa05416 | 0.25080485 |
| 107 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.25034195 |
| 108 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.24768715 |
| 109 | * HTLV-I infection_Homo sapiens_hsa05166 | 0.24286623 |
| 110 | Nicotine addiction_Homo sapiens_hsa05033 | 0.22529679 |
| 111 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.21937652 |
| 112 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.21746069 |
| 113 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.21694951 |
| 114 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.21576844 |
| 115 | Tight junction_Homo sapiens_hsa04530 | 0.21380192 |
| 116 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.20898251 |
| 117 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.20415814 |
| 118 | Phagosome_Homo sapiens_hsa04145 | 0.20320685 |
| 119 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.20056731 |
| 120 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.20040551 |
| 121 | Alcoholism_Homo sapiens_hsa05034 | 0.19875260 |
| 122 | Apoptosis_Homo sapiens_hsa04210 | 0.19825495 |
| 123 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.18773689 |
| 124 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.18404859 |
| 125 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.17805760 |
| 126 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.17433993 |
| 127 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.17279966 |
| 128 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.17222040 |
| 129 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.17184371 |
| 130 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.17079328 |
| 131 | Thyroid cancer_Homo sapiens_hsa05216 | 0.16892835 |
| 132 | Pathways in cancer_Homo sapiens_hsa05200 | 0.15230376 |
| 133 | Circadian rhythm_Homo sapiens_hsa04710 | 0.15040194 |
| 134 | Asthma_Homo sapiens_hsa05310 | 0.14867241 |
| 135 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.13855615 |
| 136 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.13134947 |
| 137 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.11929864 |
| 138 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.10662652 |

