ANAPC11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.77261404
2DNA deamination (GO:0045006)7.38570254
3ATP synthesis coupled proton transport (GO:0015986)6.91876367
4energy coupled proton transport, down electrochemical gradient (GO:0015985)6.91876367
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.17408333
6chaperone-mediated protein transport (GO:0072321)6.11697533
7respiratory electron transport chain (GO:0022904)5.86991459
8electron transport chain (GO:0022900)5.75977108
9proline biosynthetic process (GO:0006561)5.40521902
10protein complex biogenesis (GO:0070271)5.33160915
11transcription from mitochondrial promoter (GO:0006390)5.21823211
12replication fork processing (GO:0031297)5.15730759
13mitochondrial respiratory chain complex assembly (GO:0033108)5.00301281
14viral mRNA export from host cell nucleus (GO:0046784)4.89933639
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.89498080
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.89498080
17NADH dehydrogenase complex assembly (GO:0010257)4.89498080
18telomere maintenance via semi-conservative replication (GO:0032201)4.89306632
19regulation of mitochondrial translation (GO:0070129)4.71449123
20maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.62529918
21proteasome assembly (GO:0043248)4.42988425
22viral transcription (GO:0019083)4.40469669
23DNA strand elongation involved in DNA replication (GO:0006271)4.30168319
24pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.23669979
25translational termination (GO:0006415)4.21695526
26establishment of protein localization to mitochondrial membrane (GO:0090151)4.18422720
27formation of translation preinitiation complex (GO:0001731)4.16988806
28cullin deneddylation (GO:0010388)4.15476914
29telomere maintenance via recombination (GO:0000722)4.10616592
30DNA strand elongation (GO:0022616)4.07981066
31protein deneddylation (GO:0000338)4.06068142
32nucleotide-excision repair, DNA gap filling (GO:0006297)4.03796428
33spliceosomal snRNP assembly (GO:0000387)4.02155967
34protein neddylation (GO:0045116)3.95154721
35ribosomal small subunit biogenesis (GO:0042274)3.94291951
36ribosomal small subunit assembly (GO:0000028)3.88789309
37ATP biosynthetic process (GO:0006754)3.86562889
38proline metabolic process (GO:0006560)3.85119019
39regulation of cellular amino acid metabolic process (GO:0006521)3.81308344
40purine nucleoside triphosphate biosynthetic process (GO:0009145)3.80475891
41translational initiation (GO:0006413)3.78713483
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.78523772
43hydrogen ion transmembrane transport (GO:1902600)3.77619299
44GDP-mannose metabolic process (GO:0019673)3.76685794
45DNA strand renaturation (GO:0000733)3.76678896
46translational elongation (GO:0006414)3.76562971
47base-excision repair, AP site formation (GO:0006285)3.71016060
48* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.70952107
49ribosomal large subunit biogenesis (GO:0042273)3.70236086
50respiratory chain complex IV assembly (GO:0008535)3.69529365
51cytochrome complex assembly (GO:0017004)3.69356181
52SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.68430286
53sequestering of actin monomers (GO:0042989)3.67746996
54* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67209664
55somatic hypermutation of immunoglobulin genes (GO:0016446)3.67143101
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.67143101
57protein localization to mitochondrion (GO:0070585)3.62266578
58cotranslational protein targeting to membrane (GO:0006613)3.62188172
59termination of RNA polymerase III transcription (GO:0006386)3.61640751
60transcription elongation from RNA polymerase III promoter (GO:0006385)3.61640751
61protein targeting to ER (GO:0045047)3.58995246
62inner mitochondrial membrane organization (GO:0007007)3.58585487
63rRNA modification (GO:0000154)3.57037539
64pseudouridine synthesis (GO:0001522)3.56354508
65telomere maintenance via telomere lengthening (GO:0010833)3.55152753
66* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.54915619
67signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.53121654
68signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.53121654
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.53121654
70GTP biosynthetic process (GO:0006183)3.53066567
71mitotic recombination (GO:0006312)3.52941471
72base-excision repair (GO:0006284)3.52484785
73mitochondrial DNA metabolic process (GO:0032042)3.52307580
74DNA double-strand break processing (GO:0000729)3.51106611
75maturation of 5.8S rRNA (GO:0000460)3.48677837
76regulation of double-strand break repair via homologous recombination (GO:0010569)3.47557449
77positive regulation of protein homooligomerization (GO:0032464)3.46499375
78transcription-coupled nucleotide-excision repair (GO:0006283)3.45941301
79tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45637030
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45637030
81ribonucleoprotein complex biogenesis (GO:0022613)3.45011724
82viral life cycle (GO:0019058)3.44881700
83kinetochore assembly (GO:0051382)3.44654219
84oxidative demethylation (GO:0070989)3.44273886
85spliceosomal complex assembly (GO:0000245)3.42660340
86ribonucleoside triphosphate biosynthetic process (GO:0009201)3.42549286
87chromatin remodeling at centromere (GO:0031055)3.42071876
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40980192
89maturation of SSU-rRNA (GO:0030490)3.40966923
90signal transduction involved in DNA integrity checkpoint (GO:0072401)3.39131712
91signal transduction involved in DNA damage checkpoint (GO:0072422)3.39131712
92cellular protein complex disassembly (GO:0043624)3.38037207
93establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38000783
94signal transduction involved in cell cycle checkpoint (GO:0072395)3.37104954
95protein localization to endoplasmic reticulum (GO:0070972)3.36359137
96protein targeting to membrane (GO:0006612)3.34834951
97pyrimidine nucleotide catabolic process (GO:0006244)3.34256863
98DNA integration (GO:0015074)3.33821920
99nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32734815
100CENP-A containing nucleosome assembly (GO:0034080)3.32644970
101proton transport (GO:0015992)3.32017615
102pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.31579473
103establishment of viral latency (GO:0019043)3.29911315
104nuclear envelope reassembly (GO:0031468)3.28324619
105mitotic nuclear envelope reassembly (GO:0007084)3.28324619
106translation (GO:0006412)3.26804255
107rRNA processing (GO:0006364)3.26666054
108hydrogen transport (GO:0006818)3.24119591
109DNA ligation (GO:0006266)3.23883446
110ribosome biogenesis (GO:0042254)3.23193701
111* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.22839247
112protein-cofactor linkage (GO:0018065)3.20501788
113DNA replication checkpoint (GO:0000076)3.20372044
114oxidative phosphorylation (GO:0006119)3.19826932
115mitochondrial transport (GO:0006839)3.19780432
116intracellular protein transmembrane import (GO:0044743)3.15386494
117nucleoside triphosphate biosynthetic process (GO:0009142)3.14786731
118deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14170330
119rRNA metabolic process (GO:0016072)3.13343593
120DNA damage response, detection of DNA damage (GO:0042769)3.12227017
121nuclear-transcribed mRNA catabolic process (GO:0000956)3.11178134
122exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09457181
123* positive regulation of ligase activity (GO:0051351)3.07671043
124UTP biosynthetic process (GO:0006228)3.07551023
125termination of RNA polymerase II transcription (GO:0006369)3.03756330
1267-methylguanosine mRNA capping (GO:0006370)3.02682895
127embryonic process involved in female pregnancy (GO:0060136)3.01848224
128DNA replication initiation (GO:0006270)3.00383543
129mitochondrial DNA replication (GO:0006264)3.00205135
130negative regulation of cell cycle arrest (GO:0071157)3.00103079
131mitochondrial RNA metabolic process (GO:0000959)2.98796145
132positive regulation of developmental pigmentation (GO:0048087)2.98056281
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97441906
134protein complex disassembly (GO:0043241)2.97373767
135negative regulation of JAK-STAT cascade (GO:0046426)2.96437922
136protein targeting to mitochondrion (GO:0006626)2.96373462
137* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95935697
138cellular component biogenesis (GO:0044085)2.93551105
139establishment of protein localization to mitochondrion (GO:0072655)2.92543829
140establishment of integrated proviral latency (GO:0075713)2.91975223
141kinetochore organization (GO:0051383)2.91233469
142* negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86560372
143* negative regulation of ligase activity (GO:0051352)2.86560372
144DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84054144
145negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.82169685
146non-recombinational repair (GO:0000726)2.81483820
147double-strand break repair via nonhomologous end joining (GO:0006303)2.81483820
148macromolecular complex disassembly (GO:0032984)2.80676378
149single strand break repair (GO:0000012)2.80234472
150deoxyribonucleotide catabolic process (GO:0009264)2.79148719
151DNA-templated transcription, termination (GO:0006353)2.78961344
152negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.78893975
153signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78242374
154intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78242374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.10969383
2E2F7_22180533_ChIP-Seq_HELA_Human4.01503854
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56387686
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.55268987
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40885318
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25332459
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.16232401
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.12241481
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.11213620
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.07400753
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92272101
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.77595530
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.70551415
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70450434
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55668799
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.53181278
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49667639
18XRN2_22483619_ChIP-Seq_HELA_Human2.38431773
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35313681
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28554119
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.28009618
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27586573
23DCP1A_22483619_ChIP-Seq_HELA_Human2.20954465
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20334115
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09500719
26GABP_19822575_ChIP-Seq_HepG2_Human2.05156117
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03609745
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03609745
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03609745
30VDR_23849224_ChIP-Seq_CD4+_Human2.02851360
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.99230389
32TTF2_22483619_ChIP-Seq_HELA_Human1.96377681
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91537994
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86967626
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.85279163
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78563705
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.78130152
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77298809
39MYC_18940864_ChIP-ChIP_HL60_Human1.75864194
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75639178
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.74139186
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70462721
43* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.69846884
44* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69280167
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68888371
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67785228
47FOXP3_21729870_ChIP-Seq_TREG_Human1.67354686
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66509407
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64990919
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61349029
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55204177
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52079287
53VDR_21846776_ChIP-Seq_THP-1_Human1.50881179
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49658982
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49057001
56* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48336159
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46697701
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46380329
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43279290
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41795132
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38994880
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37747340
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36138771
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35596073
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34338865
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.30508338
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29808400
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28175587
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27803410
70NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.27266811
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.26106042
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25619334
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25373058
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24962261
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23321834
76ELK1_19687146_ChIP-ChIP_HELA_Human1.21096726
77KDM5A_27292631_Chip-Seq_BREAST_Human1.20829552
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20681503
79NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.19482953
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19040561
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18107994
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17889106
83SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17671527
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.17486168
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16341581
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16176901
87* TET1_21451524_ChIP-Seq_MESCs_Mouse1.15858746
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15233732
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.13794841
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13737380
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.12148914
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10215656
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10125506
94* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07970322
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07604086
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05046399
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04257392
98* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04163804
99POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03869462
100POU5F1_16518401_ChIP-PET_MESCs_Mouse1.03767138
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03733229
102E2F1_21310950_ChIP-Seq_MCF-7_Human1.03526660
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03524711
104CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01981765
105TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01810507
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01683979
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00086280
108FOXP1_21924763_ChIP-Seq_HESCs_Human0.99964168
109ZNF274_21170338_ChIP-Seq_K562_Hela0.99795354
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98449493
111VDR_22108803_ChIP-Seq_LS180_Human0.97301618
112* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97281951
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.96540872
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95203602
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93588279
116NANOG_16153702_ChIP-ChIP_HESCs_Human0.92049880
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91969550
118TFEB_21752829_ChIP-Seq_HELA_Human0.91768392
119IRF1_19129219_ChIP-ChIP_H3396_Human0.86204609
120PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83775535
121TP53_22573176_ChIP-Seq_HFKS_Human0.81859681
122EWS_26573619_Chip-Seq_HEK293_Human0.76160993
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.75505996
124HTT_18923047_ChIP-ChIP_STHdh_Human0.75195757
125PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.72248903
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.71528856
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.70917416
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70664681
129CIITA_25753668_ChIP-Seq_RAJI_Human0.70130199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.37746965
2MP0010030_abnormal_orbit_morphology3.45549726
3MP0003693_abnormal_embryo_hatching3.39273892
4MP0005171_absent_coat_pigmentation3.23484818
5MP0004957_abnormal_blastocyst_morpholog3.10904837
6MP0003806_abnormal_nucleotide_metabolis3.08903276
7MP0010094_abnormal_chromosome_stability3.06098077
8MP0008932_abnormal_embryonic_tissue2.99071256
9MP0008058_abnormal_DNA_repair2.72376157
10MP0003186_abnormal_redox_activity2.58636002
11MP0003111_abnormal_nucleus_morphology2.57446306
12MP0003077_abnormal_cell_cycle2.49638720
13MP0003136_yellow_coat_color2.42804960
14MP0004133_heterotaxia2.42692406
15MP0003786_premature_aging2.27098084
16MP0009278_abnormal_bone_marrow2.17554157
17MP0006292_abnormal_olfactory_placode1.97471211
18MP0002837_dystrophic_cardiac_calcinosis1.95578360
19MP0005075_abnormal_melanosome_morpholog1.94672162
20MP0002736_abnormal_nociception_after1.92131516
21MP0005174_abnormal_tail_pigmentation1.90042095
22MP0001986_abnormal_taste_sensitivity1.88281360
23MP0002653_abnormal_ependyma_morphology1.85120412
24MP0005084_abnormal_gallbladder_morpholo1.84792874
25MP0009379_abnormal_foot_pigmentation1.80148320
26MP0008877_abnormal_DNA_methylation1.77572376
27MP0006072_abnormal_retinal_apoptosis1.72824753
28MP0004233_abnormal_muscle_weight1.69224321
29MP0006035_abnormal_mitochondrial_morpho1.66270701
30MP0003718_maternal_effect1.65091059
31MP0003011_delayed_dark_adaptation1.63685178
32MP0000490_abnormal_crypts_of1.59495206
33MP0008007_abnormal_cellular_replicative1.52672383
34MP0002277_abnormal_respiratory_mucosa1.47404018
35MP0009333_abnormal_splenocyte_physiolog1.44481516
36MP0008995_early_reproductive_senescence1.43404162
37MP0002249_abnormal_larynx_morphology1.41215509
38MP0002751_abnormal_autonomic_nervous1.41035366
39MP0000049_abnormal_middle_ear1.39775319
40MP0004142_abnormal_muscle_tone1.36476856
41MP0001968_abnormal_touch/_nociception1.32923457
42MP0000350_abnormal_cell_proliferation1.30322318
43MP0006276_abnormal_autonomic_nervous1.29881908
44MP0001293_anophthalmia1.27723108
45MP0003121_genomic_imprinting1.27660584
46MP0003880_abnormal_central_pattern1.27189649
47MP0000015_abnormal_ear_pigmentation1.26977990
48MP0001697_abnormal_embryo_size1.26588865
49MP0002009_preneoplasia1.26399937
50MP0000631_abnormal_neuroendocrine_gland1.25374123
51MP0003890_abnormal_embryonic-extraembry1.24389841
52MP0002085_abnormal_embryonic_tissue1.24132805
53MP0005408_hypopigmentation1.21563727
54MP0001188_hyperpigmentation1.21400904
55MP0002163_abnormal_gland_morphology1.20982007
56MP0001545_abnormal_hematopoietic_system1.19176474
57MP0005397_hematopoietic_system_phenotyp1.19176474
58MP0002234_abnormal_pharynx_morphology1.18377725
59MP0002095_abnormal_skin_pigmentation1.16953452
60MP0009697_abnormal_copulation1.16739219
61MP0001485_abnormal_pinna_reflex1.16712314
62MP0002132_abnormal_respiratory_system1.16688062
63MP0003567_abnormal_fetal_cardiomyocyte1.14067820
64MP0005646_abnormal_pituitary_gland1.13858547
65MP0000313_abnormal_cell_death1.12538855
66MP0001730_embryonic_growth_arrest1.10653774
67MP0001984_abnormal_olfaction1.09727641
68MP0001764_abnormal_homeostasis1.08697690
69MP0005253_abnormal_eye_physiology1.07962090
70MP0009046_muscle_twitch1.06124130
71MP0003122_maternal_imprinting1.04689937
72MP0002938_white_spotting1.04558359
73MP0001529_abnormal_vocalization1.04517403
74MP0001348_abnormal_lacrimal_gland1.04303165
75MP0005551_abnormal_eye_electrophysiolog1.02942370
76MP0005645_abnormal_hypothalamus_physiol1.02757396
77MP0003123_paternal_imprinting1.01951956
78MP0003119_abnormal_digestive_system1.00519089
79MP0000762_abnormal_tongue_morphology1.00229135
80MP0002084_abnormal_developmental_patter0.99770600
81MP0002080_prenatal_lethality0.98337301
82MP0000026_abnormal_inner_ear0.97638378
83MP0002019_abnormal_tumor_incidence0.96807937
84MP0008789_abnormal_olfactory_epithelium0.96807212
85MP0000566_synostosis0.95711376
86MP0008875_abnormal_xenobiotic_pharmacok0.95342337
87MP0005380_embryogenesis_phenotype0.94983223
88MP0001672_abnormal_embryogenesis/_devel0.94983223
89MP0005377_hearing/vestibular/ear_phenot0.93782974
90MP0003878_abnormal_ear_physiology0.93782974
91MP0002210_abnormal_sex_determination0.91626682
92MP0002111_abnormal_tail_morphology0.91403972
93MP0008872_abnormal_physiological_respon0.90307638
94MP0003315_abnormal_perineum_morphology0.89782797
95MP0001145_abnormal_male_reproductive0.88934993
96MP0002114_abnormal_axial_skeleton0.85191572
97MP0005389_reproductive_system_phenotype0.85127693
98MP0002282_abnormal_trachea_morphology0.84719271
99MP0002932_abnormal_joint_morphology0.84609370
100MP0002233_abnormal_nose_morphology0.83472338
101MP0004145_abnormal_muscle_electrophysio0.83412466
102MP0003755_abnormal_palate_morphology0.82413526
103MP0003646_muscle_fatigue0.82066657
104MP0005332_abnormal_amino_acid0.81560137
105MP0000462_abnormal_digestive_system0.81226822
106MP0002116_abnormal_craniofacial_bone0.81102404
107MP0000470_abnormal_stomach_morphology0.80989140
108MP0003937_abnormal_limbs/digits/tail_de0.80828261
109MP0003656_abnormal_erythrocyte_physiolo0.80621781
110MP0002272_abnormal_nervous_system0.80375636
111MP0001286_abnormal_eye_development0.79310398
112MP0005195_abnormal_posterior_eye0.78992131
113MP0002396_abnormal_hematopoietic_system0.78773201
114MP0002752_abnormal_somatic_nervous0.77470340
115MP0004742_abnormal_vestibular_system0.76982010
116MP0009745_abnormal_behavioral_response0.76873519
117MP0000749_muscle_degeneration0.76865249
118MP0002822_catalepsy0.75751267
119MP0005391_vision/eye_phenotype0.74741177
120MP0003283_abnormal_digestive_organ0.74701304
121MP0001919_abnormal_reproductive_system0.74305747
122MP0003137_abnormal_impulse_conducting0.73950854
123MP0000678_abnormal_parathyroid_gland0.73348793
124MP0001346_abnormal_lacrimal_gland0.72431796
125MP0002876_abnormal_thyroid_physiology0.71970270
126MP0000778_abnormal_nervous_system0.71492093
127MP0000358_abnormal_cell_content/0.71409141
128MP0002086_abnormal_extraembryonic_tissu0.70665122
129MP0003984_embryonic_growth_retardation0.70326855
130MP0001929_abnormal_gametogenesis0.69905363
131MP0002127_abnormal_cardiovascular_syste0.68683202
132MP0003938_abnormal_ear_development0.68640887
133MP0002638_abnormal_pupillary_reflex0.68607172
134MP0004147_increased_porphyrin_level0.67964575
135MP0002160_abnormal_reproductive_system0.67500038
136MP0003385_abnormal_body_wall0.66829036
137MP0002102_abnormal_ear_morphology0.65817781
138MP0001905_abnormal_dopamine_level0.65103277
139MP0000653_abnormal_sex_gland0.65022604
140MP0006036_abnormal_mitochondrial_physio0.64986456
141MP0002075_abnormal_coat/hair_pigmentati0.64933894
142MP0002088_abnormal_embryonic_growth/wei0.64929208
143MP0003950_abnormal_plasma_membrane0.64610473
144MP0004197_abnormal_fetal_growth/weight/0.64386162
145MP0003763_abnormal_thymus_physiology0.61818663
146MP0000372_irregular_coat_pigmentation0.60704359
147MP0000689_abnormal_spleen_morphology0.60339924
148MP0000681_abnormal_thyroid_gland0.59437568
149MP0005394_taste/olfaction_phenotype0.59395634
150MP0005499_abnormal_olfactory_system0.59395634

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)4.47343003
2Lipid accumulation in hepatocytes (HP:0006561)4.39592426
3Renal Fanconi syndrome (HP:0001994)4.26748837
4Cerebral edema (HP:0002181)4.12469456
5Cerebral hypomyelination (HP:0006808)3.79751642
6Increased intramyocellular lipid droplets (HP:0012240)3.79109609
7Rib fusion (HP:0000902)3.59667751
8Rectal fistula (HP:0100590)3.49150019
9Rectovaginal fistula (HP:0000143)3.49150019
10Tongue fasciculations (HP:0001308)3.49036586
11Reticulocytopenia (HP:0001896)3.42705206
12Increased IgM level (HP:0003496)3.41536072
13Aplasia/Hypoplasia of the sacrum (HP:0008517)3.40726908
14Lactic acidosis (HP:0003128)3.32161200
15Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.31284820
16Acute necrotizing encephalopathy (HP:0006965)3.26208959
17Increased muscle lipid content (HP:0009058)3.20422650
18Absent radius (HP:0003974)3.18159705
19Abnormality of cells of the erythroid lineage (HP:0012130)3.13382752
20Selective tooth agenesis (HP:0001592)3.12420971
21Muscle fibrillation (HP:0010546)3.08914210
22Breast hypoplasia (HP:0003187)3.04007992
23Abnormal hemoglobin (HP:0011902)3.03725310
24Patellar aplasia (HP:0006443)2.99530567
25Absent forearm bone (HP:0003953)2.98819031
26Aplasia involving forearm bones (HP:0009822)2.98819031
27Optic disc pallor (HP:0000543)2.97471040
28Absent thumb (HP:0009777)2.97424628
29Premature graying of hair (HP:0002216)2.97184654
30Abnormal mitochondria in muscle tissue (HP:0008316)2.96861927
31Abnormal number of erythroid precursors (HP:0012131)2.96335778
32Exertional dyspnea (HP:0002875)2.96135302
33Hepatocellular necrosis (HP:0001404)2.95491532
34Mitochondrial inheritance (HP:0001427)2.92875929
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91242833
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91242833
37Aplasia/Hypoplasia of the patella (HP:0006498)2.85341407
38Intestinal fistula (HP:0100819)2.80246601
39Vaginal fistula (HP:0004320)2.77744345
40Abnormality of the ileum (HP:0001549)2.73451343
41Supernumerary spleens (HP:0009799)2.72642396
42Respiratory difficulties (HP:0002880)2.62378229
43Methylmalonic aciduria (HP:0012120)2.56522244
44Congenital, generalized hypertrichosis (HP:0004540)2.54072744
45Lethargy (HP:0001254)2.52078699
46Abnormality of renal resorption (HP:0011038)2.51531066
47Methylmalonic acidemia (HP:0002912)2.48587543
48Increased CSF lactate (HP:0002490)2.44776000
49Intestinal atresia (HP:0011100)2.44700616
50Birth length less than 3rd percentile (HP:0003561)2.42382951
51Facial hemangioma (HP:0000329)2.39566595
52Colon cancer (HP:0003003)2.39558959
53Hypoplasia of the radius (HP:0002984)2.38145491
54Coronal craniosynostosis (HP:0004440)2.32948080
55Macrocytic anemia (HP:0001972)2.32692199
56Acute encephalopathy (HP:0006846)2.31081673
57Generalized aminoaciduria (HP:0002909)2.30135259
58Muscle fiber atrophy (HP:0100295)2.29495976
59Abnormal number of incisors (HP:0011064)2.28093704
60Increased serum lactate (HP:0002151)2.28004875
61Annular pancreas (HP:0001734)2.27691086
62Pancreatic fibrosis (HP:0100732)2.27122919
63X-linked dominant inheritance (HP:0001423)2.26854173
64Progressive macrocephaly (HP:0004481)2.26650661
65Pallor (HP:0000980)2.26153011
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.25735288
67Rough bone trabeculation (HP:0100670)2.25144380
68Type I transferrin isoform profile (HP:0003642)2.25007625
69Abnormality of the labia minora (HP:0012880)2.24898641
70Pancreatic cysts (HP:0001737)2.24734284
71Poikiloderma (HP:0001029)2.24651508
72Glycosuria (HP:0003076)2.24442795
73Abnormality of urine glucose concentration (HP:0011016)2.24442795
74Aplasia/hypoplasia of the humerus (HP:0006507)2.23205788
75Hyperglycinemia (HP:0002154)2.21794764
76CNS demyelination (HP:0007305)2.21599479
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21527454
78Hepatic necrosis (HP:0002605)2.21454739
79Redundant skin (HP:0001582)2.21367505
80Orthostatic hypotension (HP:0001278)2.19820464
81Alacrima (HP:0000522)2.18138360
82Abnormality of midbrain morphology (HP:0002418)2.13177173
83Molar tooth sign on MRI (HP:0002419)2.13177173
84Exercise intolerance (HP:0003546)2.12619129
85Meckel diverticulum (HP:0002245)2.10814367
86Increased serum pyruvate (HP:0003542)2.07666265
87Abnormality of the aortic arch (HP:0012303)2.06990090
88Hyperphosphaturia (HP:0003109)2.06616882
89Abnormal protein glycosylation (HP:0012346)2.05481524
90Abnormal glycosylation (HP:0012345)2.05481524
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05481524
92Abnormal protein N-linked glycosylation (HP:0012347)2.05481524
93Type 2 muscle fiber atrophy (HP:0003554)2.04891230
94Respiratory failure (HP:0002878)2.04833246
95Dysautonomia (HP:0002459)2.03491993
96True hermaphroditism (HP:0010459)2.03212215
97Septo-optic dysplasia (HP:0100842)2.03198638
98Hypokinesia (HP:0002375)2.02974149
99Sclerocornea (HP:0000647)2.02413166
100Myokymia (HP:0002411)2.01772549
101Albinism (HP:0001022)2.01193000
102Pancytopenia (HP:0001876)2.01141232
103Broad alveolar ridges (HP:0000187)2.00020225
104Asplenia (HP:0001746)1.98797788
105Oral leukoplakia (HP:0002745)1.97729663
106Trismus (HP:0000211)1.97279833
1073-Methylglutaconic aciduria (HP:0003535)1.96435242
108Diaphragmatic weakness (HP:0009113)1.94866669
109Pustule (HP:0200039)1.94490632
110Duplicated collecting system (HP:0000081)1.93284264
111Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92026376
112Dicarboxylic aciduria (HP:0003215)1.92026376
113Emotional lability (HP:0000712)1.91706682
114Medial flaring of the eyebrow (HP:0010747)1.90997467
115Carpal bone hypoplasia (HP:0001498)1.90932648
116Abnormality of male internal genitalia (HP:0000022)1.89550764
117Triphalangeal thumb (HP:0001199)1.88456877
118Abnormality of the preputium (HP:0100587)1.88355685
119Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87601318
120Degeneration of anterior horn cells (HP:0002398)1.87517145
121Abnormality of the anterior horn cell (HP:0006802)1.87517145
122Squamous cell carcinoma (HP:0002860)1.87197824
123Abdominal situs inversus (HP:0003363)1.85699960
124Abnormality of abdominal situs (HP:0011620)1.85699960
125Increased hepatocellular lipid droplets (HP:0006565)1.84738751
126Abnormality of alanine metabolism (HP:0010916)1.84109817
127Hyperalaninemia (HP:0003348)1.84109817
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84109817
129Premature skin wrinkling (HP:0100678)1.84065206
130Aplasia of the musculature (HP:0100854)1.83846216
131Microvesicular hepatic steatosis (HP:0001414)1.82127863
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.79365747
133Hypoplasia of the pons (HP:0012110)1.79365267
134Aplastic anemia (HP:0001915)1.79027590
135Leukodystrophy (HP:0002415)1.78871506
136Abnormality of glycolysis (HP:0004366)1.78659935
137Decreased lacrimation (HP:0000633)1.78014635
138Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77742823
139Vertebral hypoplasia (HP:0008417)1.77742823
140Congenital stationary night blindness (HP:0007642)1.76750409
141Abnormality of placental membranes (HP:0011409)1.76372515
142Amniotic constriction ring (HP:0009775)1.76372515
143Delayed CNS myelination (HP:0002188)1.76180461
144Absent septum pellucidum (HP:0001331)1.75742586
145Blindness (HP:0000618)1.75562757
146Aplasia/Hypoplasia of the spleen (HP:0010451)1.75031110
147Aplasia/hypoplasia of the uterus (HP:0008684)1.73635140
148Poor suck (HP:0002033)1.72133409
149Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.68917611
150Testicular atrophy (HP:0000029)1.68685526
151Pendular nystagmus (HP:0012043)1.66416986
152Hypoplastic pelvis (HP:0008839)1.65368363
153Abnormality of serum amino acid levels (HP:0003112)1.64989600
154Reduced antithrombin III activity (HP:0001976)1.63663121
155Abnormality of the pons (HP:0007361)1.63014398
156Sparse eyelashes (HP:0000653)1.62838272
157Cleft eyelid (HP:0000625)1.62744720
158Short tibia (HP:0005736)1.61241578
159Progressive microcephaly (HP:0000253)1.59749990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.87417876
2BUB13.81852570
3TLK13.38749493
4MAPK153.24370598
5MAP3K113.14650006
6ICK3.09923466
7PIM23.08283534
8TESK22.96617548
9NME22.65102809
10BCKDK2.50375419
11DDR22.38888382
12MATK2.36752092
13WEE12.32980979
14UHMK12.32922696
15MAP3K62.32189792
16EIF2AK12.06687121
17PINK11.94223946
18STK161.83745638
19NUAK11.82371099
20YES11.79589563
21CDK71.77959960
22SRPK11.65198567
23WNK31.58074953
24DAPK11.54789392
25VRK11.48901400
26PLK11.45302111
27MAP4K21.41966940
28LIMK11.40097341
29PLK31.40016128
30PDK21.36311092
31BMPR1B1.34959828
32CDC71.29598242
33DYRK21.29265465
34ARAF1.29218979
35EPHB21.27224198
36FGR1.25624654
37DYRK31.24132162
38NME11.21472816
39ABL21.19865967
40CDK191.19626644
41ADRBK21.19392931
42TESK11.19288309
43MKNK21.19202305
44LATS21.18927165
45PRKD21.18702797
46AURKA1.18148668
47MAP2K71.18134884
48CSNK1G31.17125395
49PBK1.16897775
50CHEK21.14907830
51TAF11.12995374
52MKNK11.07321762
53MUSK1.04725199
54TTK1.04375817
55CDK81.03960437
56CSNK1G21.01501292
57PRPF4B1.00967166
58PIM11.00627333
59BLK0.99446158
60CSK0.99321477
61CSNK1G10.96537477
62CASK0.93683861
63GRK10.90162337
64DYRK1B0.88639821
65PAK10.87198277
66PLK40.84519050
67AKT30.83412832
68RPS6KC10.82402535
69RPS6KL10.82402535
70BMX0.81012305
71RPS6KB20.80066960
72ATR0.79150084
73CCNB10.76465088
74MST40.75201769
75CSNK1A1L0.74778524
76STK30.73756081
77RPS6KA60.73323071
78TRIM280.73038898
79AURKB0.72824432
80CSNK2A10.72551963
81BRSK20.69286143
82INSRR0.66898729
83PRKCG0.66542333
84TYRO30.65523179
85DAPK30.65392653
86NEK20.64540047
87PRKCI0.63884591
88ILK0.63213163
89LRRK20.58891821
90PHKG20.58033121
91PHKG10.58033121
92BRAF0.57574276
93CDK11A0.57573893
94TSSK60.57508892
95MYLK0.56802223
96CDK140.56571523
97CSNK2A20.55054220
98CLK10.55053597
99KDR0.54894017
100STK240.53010874
101TAOK20.52778064
102CDK150.51970054
103STK40.51809514
104EIF2AK30.51771297
105BRSK10.51677901
106CDK180.51366787
107MAP3K120.50849883
108PLK20.50773921
109CDC42BPA0.49256847
110MAPKAPK50.48409370
111MAP3K80.47617957
112NEK10.47419370
113MINK10.47288920
114MAPK130.47051537
115PASK0.46910451
116WNK40.45494160
117CAMK2B0.45137419
118CDK20.44056716
119TNIK0.44050875
120CAMK2D0.43367465
121MAP2K20.43064354
122PNCK0.42821727
123OXSR10.42687951
124ADRBK10.42680268
125IKBKB0.42550709
126CSNK1A10.41648176
127STK100.41644655
128RPS6KA50.41145647
129PAK40.40668425
130LYN0.39942119
131OBSCN0.39771526
132CAMK2G0.39264472
133CHEK10.38837236
134ZAK0.38791005
135PKN10.38611685
136TRPM70.37913130
137EPHA20.36766075
138TIE10.35822068
139BCR0.35202468
140GRK70.34494408
141GRK50.33819799
142RPS6KA10.33579693
143PRKACA0.32742486
144MAP3K40.32525949

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.42992645
2DNA replication_Homo sapiens_hsa030304.36263754
3Mismatch repair_Homo sapiens_hsa034304.32839402
4Base excision repair_Homo sapiens_hsa034103.65367896
5Proteasome_Homo sapiens_hsa030503.38374009
6RNA polymerase_Homo sapiens_hsa030203.37163466
7Homologous recombination_Homo sapiens_hsa034403.13510754
8Spliceosome_Homo sapiens_hsa030403.02250399
9Nucleotide excision repair_Homo sapiens_hsa034202.86405172
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75412463
11Oxidative phosphorylation_Homo sapiens_hsa001902.52382994
12Parkinsons disease_Homo sapiens_hsa050122.38315116
13Fanconi anemia pathway_Homo sapiens_hsa034602.37319980
14RNA transport_Homo sapiens_hsa030132.21010902
15Pyrimidine metabolism_Homo sapiens_hsa002402.10943233
16Huntingtons disease_Homo sapiens_hsa050161.91512637
17Basal transcription factors_Homo sapiens_hsa030221.80284351
18* Cell cycle_Homo sapiens_hsa041101.72415669
19Sulfur relay system_Homo sapiens_hsa041221.42248683
20Alzheimers disease_Homo sapiens_hsa050101.41087838
21Protein export_Homo sapiens_hsa030601.39363582
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33754752
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33548380
24One carbon pool by folate_Homo sapiens_hsa006701.31858829
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30566814
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29345534
27p53 signaling pathway_Homo sapiens_hsa041151.27622695
28mRNA surveillance pathway_Homo sapiens_hsa030151.27522891
29RNA degradation_Homo sapiens_hsa030181.26669625
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24143276
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21656306
32Pyruvate metabolism_Homo sapiens_hsa006201.16289934
33Purine metabolism_Homo sapiens_hsa002301.12287039
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09543651
35Folate biosynthesis_Homo sapiens_hsa007901.06725342
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03537627
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01424433
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98123293
39Epstein-Barr virus infection_Homo sapiens_hsa051690.90851988
40Phototransduction_Homo sapiens_hsa047440.89383944
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88373089
42Peroxisome_Homo sapiens_hsa041460.87686933
43Non-homologous end-joining_Homo sapiens_hsa034500.87584404
44Propanoate metabolism_Homo sapiens_hsa006400.86482177
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85949495
46Cardiac muscle contraction_Homo sapiens_hsa042600.84767615
47Hippo signaling pathway_Homo sapiens_hsa043900.83245118
48Hedgehog signaling pathway_Homo sapiens_hsa043400.82564994
49Sulfur metabolism_Homo sapiens_hsa009200.82425049
50Fatty acid biosynthesis_Homo sapiens_hsa000610.72366896
51Arginine and proline metabolism_Homo sapiens_hsa003300.70764345
52Butanoate metabolism_Homo sapiens_hsa006500.69928268
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69778013
54Shigellosis_Homo sapiens_hsa051310.67817815
55Notch signaling pathway_Homo sapiens_hsa043300.66678568
56Primary immunodeficiency_Homo sapiens_hsa053400.63574768
57Basal cell carcinoma_Homo sapiens_hsa052170.61684410
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59266653
59Carbon metabolism_Homo sapiens_hsa012000.58817145
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.58651967
61* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56947980
62Glutathione metabolism_Homo sapiens_hsa004800.56533729
63Fructose and mannose metabolism_Homo sapiens_hsa000510.55431218
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53190981
65* Oocyte meiosis_Homo sapiens_hsa041140.52376560
66Tryptophan metabolism_Homo sapiens_hsa003800.50397504
67Selenocompound metabolism_Homo sapiens_hsa004500.50129944
68Chemical carcinogenesis_Homo sapiens_hsa052040.49622580
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49545966
70Biosynthesis of amino acids_Homo sapiens_hsa012300.49250908
71Wnt signaling pathway_Homo sapiens_hsa043100.48629134
72Tyrosine metabolism_Homo sapiens_hsa003500.48315528
73Fatty acid elongation_Homo sapiens_hsa000620.47982492
74Arachidonic acid metabolism_Homo sapiens_hsa005900.47566192
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.47500879
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47413410
77Viral carcinogenesis_Homo sapiens_hsa052030.47364941
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47325632
79TGF-beta signaling pathway_Homo sapiens_hsa043500.47016511
80Bladder cancer_Homo sapiens_hsa052190.45806253
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45451839
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.44670954
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43873979
84Legionellosis_Homo sapiens_hsa051340.43802784
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43612734
86Herpes simplex infection_Homo sapiens_hsa051680.41940592
87Metabolic pathways_Homo sapiens_hsa011000.39573424
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38420528
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37039215
90beta-Alanine metabolism_Homo sapiens_hsa004100.35951530
91Steroid biosynthesis_Homo sapiens_hsa001000.33276087
92Autoimmune thyroid disease_Homo sapiens_hsa053200.32009261
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30922061
94Fatty acid metabolism_Homo sapiens_hsa012120.30851114
95Nitrogen metabolism_Homo sapiens_hsa009100.29730124
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29303164
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29147086
98N-Glycan biosynthesis_Homo sapiens_hsa005100.27562160
99Phenylalanine metabolism_Homo sapiens_hsa003600.27488720
100Fatty acid degradation_Homo sapiens_hsa000710.26960461
101Retinol metabolism_Homo sapiens_hsa008300.26699677
102Colorectal cancer_Homo sapiens_hsa052100.26362350
103Galactose metabolism_Homo sapiens_hsa000520.25960335
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25920268
105Allograft rejection_Homo sapiens_hsa053300.25890690
106Viral myocarditis_Homo sapiens_hsa054160.25080485
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.25034195
108Pentose phosphate pathway_Homo sapiens_hsa000300.24768715
109* HTLV-I infection_Homo sapiens_hsa051660.24286623
110Nicotine addiction_Homo sapiens_hsa050330.22529679
111Linoleic acid metabolism_Homo sapiens_hsa005910.21937652
112Systemic lupus erythematosus_Homo sapiens_hsa053220.21746069
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21694951
114Vibrio cholerae infection_Homo sapiens_hsa051100.21576844
115Tight junction_Homo sapiens_hsa045300.21380192
116Vitamin digestion and absorption_Homo sapiens_hsa049770.20898251
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.20415814
118Phagosome_Homo sapiens_hsa041450.20320685
119Acute myeloid leukemia_Homo sapiens_hsa052210.20056731
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20040551
121Alcoholism_Homo sapiens_hsa050340.19875260
122Apoptosis_Homo sapiens_hsa042100.19825495
123Synaptic vesicle cycle_Homo sapiens_hsa047210.18773689
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18404859
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17805760
126Vitamin B6 metabolism_Homo sapiens_hsa007500.17433993
127Collecting duct acid secretion_Homo sapiens_hsa049660.17279966
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17222040
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.17184371
130Regulation of autophagy_Homo sapiens_hsa041400.17079328
131Thyroid cancer_Homo sapiens_hsa052160.16892835
132Pathways in cancer_Homo sapiens_hsa052000.15230376
133Circadian rhythm_Homo sapiens_hsa047100.15040194
134Asthma_Homo sapiens_hsa053100.14867241
135Antigen processing and presentation_Homo sapiens_hsa046120.13855615
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13134947
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11929864
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.10662652

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