ANAPC13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.99980675
2ribosomal small subunit assembly (GO:0000028)7.88609889
3translational termination (GO:0006415)7.62945273
4ribosomal small subunit biogenesis (GO:0042274)7.49476884
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.44409625
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.14438728
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.09027250
8ATP synthesis coupled proton transport (GO:0015986)7.04411316
9energy coupled proton transport, down electrochemical gradient (GO:0015985)7.04411316
10cotranslational protein targeting to membrane (GO:0006613)6.99769933
11protein targeting to ER (GO:0045047)6.97145192
12establishment of protein localization to endoplasmic reticulum (GO:0072599)6.62304723
13protein localization to endoplasmic reticulum (GO:0070972)6.58584377
14translational elongation (GO:0006414)6.47922851
15respiratory electron transport chain (GO:0022904)6.46850041
16electron transport chain (GO:0022900)6.30046625
17viral life cycle (GO:0019058)5.92503046
18cellular protein complex disassembly (GO:0043624)5.89727705
19ribosomal large subunit biogenesis (GO:0042273)5.84230703
20maturation of SSU-rRNA (GO:0030490)5.65827069
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.48031398
22translational initiation (GO:0006413)5.30091192
23protein complex disassembly (GO:0043241)5.03273043
24DNA deamination (GO:0045006)4.93443229
25translation (GO:0006412)4.93423791
26protein complex biogenesis (GO:0070271)4.82163147
27macromolecular complex disassembly (GO:0032984)4.80748269
28protein deneddylation (GO:0000338)4.67227640
29regulation of mitochondrial translation (GO:0070129)4.61007098
30protein targeting to membrane (GO:0006612)4.53378607
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.51214772
32mitochondrial respiratory chain complex I assembly (GO:0032981)4.51214772
33NADH dehydrogenase complex assembly (GO:0010257)4.51214772
34mitochondrial respiratory chain complex assembly (GO:0033108)4.48615492
35oxidative phosphorylation (GO:0006119)3.96454642
36proteasome assembly (GO:0043248)3.93610818
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.84019236
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.72107542
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.72107542
40respiratory chain complex IV assembly (GO:0008535)3.70685639
41GTP biosynthetic process (GO:0006183)3.69229711
42cellular component biogenesis (GO:0044085)3.69026975
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.67662957
44termination of RNA polymerase III transcription (GO:0006386)3.67662957
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.67602762
46ATP biosynthetic process (GO:0006754)3.67137919
47ribonucleoprotein complex biogenesis (GO:0022613)3.64701913
48mRNA catabolic process (GO:0006402)3.64229008
49purine nucleoside triphosphate biosynthetic process (GO:0009145)3.63647440
50chaperone-mediated protein transport (GO:0072321)3.54721846
51sequestering of actin monomers (GO:0042989)3.50856084
52hydrogen ion transmembrane transport (GO:1902600)3.47943308
53branched-chain amino acid catabolic process (GO:0009083)3.47108077
54platelet dense granule organization (GO:0060155)3.44704593
55iron-sulfur cluster assembly (GO:0016226)3.41962514
56metallo-sulfur cluster assembly (GO:0031163)3.41962514
57protein neddylation (GO:0045116)3.39441484
58intraciliary transport (GO:0042073)3.37814079
59DNA double-strand break processing (GO:0000729)3.37577013
60cytochrome complex assembly (GO:0017004)3.36007625
61RNA catabolic process (GO:0006401)3.30815248
62ribonucleoside triphosphate biosynthetic process (GO:0009201)3.26696191
63quinone biosynthetic process (GO:1901663)3.23946423
64ubiquinone biosynthetic process (GO:0006744)3.23946423
65establishment of protein localization to membrane (GO:0090150)3.19447844
66protein targeting (GO:0006605)3.17623465
67organelle disassembly (GO:1903008)3.13997375
68aerobic respiration (GO:0009060)3.13821830
69protein targeting to mitochondrion (GO:0006626)3.13721667
70protein localization to cilium (GO:0061512)3.11919576
71water-soluble vitamin biosynthetic process (GO:0042364)3.11336854
72UTP biosynthetic process (GO:0006228)3.10019717
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09609461
74preassembly of GPI anchor in ER membrane (GO:0016254)3.08559077
75epithelial cilium movement (GO:0003351)3.08003743
76positive regulation of amino acid transport (GO:0051957)3.06765317
77neuron fate determination (GO:0048664)3.03903413
78proton transport (GO:0015992)3.01768638
79signal peptide processing (GO:0006465)2.97548695
80rRNA processing (GO:0006364)2.96528487
81C-terminal protein lipidation (GO:0006501)2.95015327
82hydrogen transport (GO:0006818)2.94765109
83nonmotile primary cilium assembly (GO:0035058)2.94493220
84establishment of protein localization to mitochondrion (GO:0072655)2.94051532
85pseudouridine synthesis (GO:0001522)2.90567262
86anterograde synaptic vesicle transport (GO:0048490)2.90040595
87guanosine-containing compound biosynthetic process (GO:1901070)2.88149543
88mannosylation (GO:0097502)2.87966360
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86561988
90UTP metabolic process (GO:0046051)2.86212182
91peptidyl-histidine modification (GO:0018202)2.84856042
92L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84703033
93rRNA metabolic process (GO:0016072)2.83803862
94establishment of protein localization to organelle (GO:0072594)2.83458783
95cilium morphogenesis (GO:0060271)2.82202231
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80542578
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80280903
98nucleoside triphosphate biosynthetic process (GO:0009142)2.80054549
99establishment of protein localization to mitochondrial membrane (GO:0090151)2.79807549
100ubiquinone metabolic process (GO:0006743)2.79363037
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79340498
102regulation of cilium movement (GO:0003352)2.79252392
103C-terminal protein amino acid modification (GO:0018410)2.78649663
104spliceosomal complex assembly (GO:0000245)2.77996530
105mitochondrial transport (GO:0006839)2.77054345
106ribonucleoprotein complex disassembly (GO:0032988)2.76102932
107inner mitochondrial membrane organization (GO:0007007)2.75196688
108spliceosomal snRNP assembly (GO:0000387)2.74565411
109regulation of cellular amino acid metabolic process (GO:0006521)2.72011279
110protein localization to mitochondrion (GO:0070585)2.71574759
111aldehyde catabolic process (GO:0046185)2.71446508
112amino acid salvage (GO:0043102)2.69434015
113L-methionine salvage (GO:0071267)2.69434015
114L-methionine biosynthetic process (GO:0071265)2.69434015
115CTP metabolic process (GO:0046036)2.69075901
116CTP biosynthetic process (GO:0006241)2.69075901
117positive regulation of mitochondrial fission (GO:0090141)2.67335782
118epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66283555
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.65760084
120antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.64948403
121regulation of oxidative phosphorylation (GO:0002082)2.64511890
122protein-cofactor linkage (GO:0018065)2.64331181
123intracellular protein transmembrane import (GO:0044743)2.64156570
124heme biosynthetic process (GO:0006783)2.64121792
125GPI anchor metabolic process (GO:0006505)2.64043055
126pyrimidine nucleobase catabolic process (GO:0006208)2.63805087
127pteridine-containing compound biosynthetic process (GO:0042559)2.63794272
128histone H2A acetylation (GO:0043968)2.62556546
129DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60966091
130DNA damage response, detection of DNA damage (GO:0042769)2.59207848
131negative regulation of ligase activity (GO:0051352)2.58763237
132negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.58763237
1337-methylguanosine mRNA capping (GO:0006370)2.58399240
134pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.57332972
135cilium assembly (GO:0042384)2.56584526
136cilium organization (GO:0044782)2.56501104
137GDP-mannose metabolic process (GO:0019673)2.54763691
138positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.54539968
139GPI anchor biosynthetic process (GO:0006506)2.53070783
140cullin deneddylation (GO:0010388)2.52157453
141anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.52066118
142peptidyl-cysteine modification (GO:0018198)2.51681703
143signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.51528698
144signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.51528698
145signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.51528698
146transcription-coupled nucleotide-excision repair (GO:0006283)2.51006678
147serotonin receptor signaling pathway (GO:0007210)2.49351803
148intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.49082302
149signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.49082302
150inositol phosphate catabolic process (GO:0071545)2.47113816
151behavioral response to nicotine (GO:0035095)2.46254551
152cellular ketone body metabolic process (GO:0046950)2.45628240
153neural tube formation (GO:0001841)2.43754182
154branched-chain amino acid metabolic process (GO:0009081)2.43394084
155positive regulation of ligase activity (GO:0051351)2.43134266
156signal transduction involved in cell cycle checkpoint (GO:0072395)2.39766562
157prenylation (GO:0097354)2.38940944
158protein prenylation (GO:0018342)2.38940944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.79620294
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.57641930
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.13519036
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.86951302
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.85274405
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.84925505
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.51655269
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.48197774
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.35489387
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.22477158
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16864918
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.16127736
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82562966
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81737522
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.72545239
16ZNF274_21170338_ChIP-Seq_K562_Hela2.71330747
17* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70811179
18IGF1R_20145208_ChIP-Seq_DFB_Human2.53242255
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.49916022
20* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49365695
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44762311
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.44737948
23XRN2_22483619_ChIP-Seq_HELA_Human2.44710470
24DCP1A_22483619_ChIP-Seq_HELA_Human2.43425122
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.40836453
26VDR_22108803_ChIP-Seq_LS180_Human2.36166011
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34178658
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.34045947
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30116193
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.29696041
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25299377
32VDR_23849224_ChIP-Seq_CD4+_Human2.24737171
33FUS_26573619_Chip-Seq_HEK293_Human2.23383679
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22210817
35EWS_26573619_Chip-Seq_HEK293_Human2.15112764
36TAF15_26573619_Chip-Seq_HEK293_Human2.14065298
37GBX2_23144817_ChIP-Seq_PC3_Human2.13015902
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.03228169
39FLI1_27457419_Chip-Seq_LIVER_Mouse2.01552428
40TTF2_22483619_ChIP-Seq_HELA_Human2.01550585
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.99464860
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.95531865
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95506108
44P300_19829295_ChIP-Seq_ESCs_Human1.89708171
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87589058
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84422748
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80974230
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75906132
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75626617
50* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73782043
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72610254
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65949801
53* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62982449
54* GABP_19822575_ChIP-Seq_HepG2_Human1.62700082
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62307197
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.60993780
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.60954141
58* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60889015
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59554667
60* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59514199
61* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57372804
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55363206
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54740708
64ELK1_19687146_ChIP-ChIP_HELA_Human1.53982497
65* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.53911432
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50065855
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49956069
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49895959
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49072091
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44473912
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42453532
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41758443
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40610605
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38996154
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38852313
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35095061
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34964035
78MYC_18940864_ChIP-ChIP_HL60_Human1.34445275
79TP53_22573176_ChIP-Seq_HFKS_Human1.34194878
80RNF2_27304074_Chip-Seq_NSC_Mouse1.31716245
81CTCF_18555785_ChIP-Seq_MESCs_Mouse1.30836769
82ER_23166858_ChIP-Seq_MCF-7_Human1.29877190
83* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29443104
84* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29190826
85* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28435332
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26838762
87SMAD4_21799915_ChIP-Seq_A2780_Human1.26639043
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26377297
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25761826
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25341418
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24417544
92CBP_20019798_ChIP-Seq_JUKART_Human1.24417544
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24135908
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24033717
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23954231
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.22891993
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22674285
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22280346
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.21435487
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.19991462
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18391052
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18321453
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.17416831
104SOX2_19829295_ChIP-Seq_ESCs_Human1.16543523
105NANOG_19829295_ChIP-Seq_ESCs_Human1.16543523
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15256054
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.14808138
108* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14523800
109RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14514747
110HTT_18923047_ChIP-ChIP_STHdh_Human1.14384019
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13184072
112AR_25329375_ChIP-Seq_VCAP_Human1.12786713
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12352626
114* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10075989
115YY1_22570637_ChIP-Seq_MALME-3M_Human1.09167441
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09145935
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08952645
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08746246
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08316361
120NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08103167
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07432361
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.07177381
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06942609
124STAT1_20625510_ChIP-Seq_HELA_Human1.06692107
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06676551
126IRF1_19129219_ChIP-ChIP_H3396_Human1.06437832
127P53_22387025_ChIP-Seq_ESCs_Mouse1.06406211
128ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03793069
129BCAT_22108803_ChIP-Seq_LS180_Human1.03501673
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02159468
131NANOG_16153702_ChIP-ChIP_HESCs_Human1.00808651
132SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00595736
133CIITA_25753668_ChIP-Seq_RAJI_Human1.00052910
134FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00009359
135FOXA1_25329375_ChIP-Seq_VCAP_Human1.00009359
136CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99478707
137TAL1_26923725_Chip-Seq_HPCs_Mouse0.98483669
138TCF4_22108803_ChIP-Seq_LS180_Human0.98020308
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97538451
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.97348267
141E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97004822
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.96813746
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96538161
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95175523
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94801068
146E2F1_18555785_Chip-Seq_ESCs_Mouse0.94173503
147STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91816789
148PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91218736
149* SOX17_20123909_ChIP-Seq_XEN_Mouse0.90969947
150OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89983544
151* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88558625
152PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88093063
153CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87880654
154SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87493289
155CTCF_26484167_Chip-Seq_Bcells_Mouse0.86879544
156TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83249121
157NANOG_20526341_ChIP-Seq_ESCs_Human0.82826405
158YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82459843
159RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82340733
160TET1_21451524_ChIP-Seq_MESCs_Mouse0.82325011
161E2F7_22180533_ChIP-Seq_HELA_Human0.80471308
162STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79459548
163SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79277635
164PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78834022
165ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78578628
166SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.77627414
167BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76360531
168* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75353379
169TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74413054
170PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74215351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.99070295
2MP0002837_dystrophic_cardiac_calcinosis3.21480162
3MP0003806_abnormal_nucleotide_metabolis3.04774864
4MP0002102_abnormal_ear_morphology2.99701627
5MP0003011_delayed_dark_adaptation2.93200827
6MP0003186_abnormal_redox_activity2.92814501
7MP0003880_abnormal_central_pattern2.76531956
8MP0006036_abnormal_mitochondrial_physio2.71529906
9MP0003136_yellow_coat_color2.70989144
10MP0002132_abnormal_respiratory_system2.58728085
11MP0004381_abnormal_hair_follicle2.49918279
12MP0002822_catalepsy2.49623515
13MP0001984_abnormal_olfaction2.39881121
14MP0003195_calcinosis2.27432600
15MP0003693_abnormal_embryo_hatching2.24348868
16MP0003646_muscle_fatigue2.14031895
17MP0000566_synostosis2.11065044
18MP0008877_abnormal_DNA_methylation2.03096822
19MP0003122_maternal_imprinting2.00172044
20MP0002277_abnormal_respiratory_mucosa1.98649294
21MP0005253_abnormal_eye_physiology1.91132803
22MP0002163_abnormal_gland_morphology1.91025571
23MP0005451_abnormal_body_composition1.90974394
24MP0002234_abnormal_pharynx_morphology1.89379710
25MP0003787_abnormal_imprinting1.85075871
26MP0005085_abnormal_gallbladder_physiolo1.83301513
27MP0002638_abnormal_pupillary_reflex1.79065320
28MP0003121_genomic_imprinting1.75946674
29MP0000749_muscle_degeneration1.74593199
30MP0002139_abnormal_hepatobiliary_system1.73614898
31MP0009046_muscle_twitch1.73491003
32MP0005379_endocrine/exocrine_gland_phen1.72587627
33MP0002736_abnormal_nociception_after1.71634982
34MP0006276_abnormal_autonomic_nervous1.67715702
35MP0004043_abnormal_pH_regulation1.63153516
36MP0005551_abnormal_eye_electrophysiolog1.62966160
37MP0001529_abnormal_vocalization1.62249678
38MP0004957_abnormal_blastocyst_morpholog1.58437130
39MP0005394_taste/olfaction_phenotype1.57099695
40MP0005499_abnormal_olfactory_system1.57099695
41MP0008004_abnormal_stomach_pH1.56527225
42MP0010030_abnormal_orbit_morphology1.55810373
43MP0005367_renal/urinary_system_phenotyp1.49587622
44MP0000516_abnormal_urinary_system1.49587622
45MP0008932_abnormal_embryonic_tissue1.49127004
46MP0000372_irregular_coat_pigmentation1.48068906
47MP0005645_abnormal_hypothalamus_physiol1.46077214
48MP0001764_abnormal_homeostasis1.44114103
49MP0002751_abnormal_autonomic_nervous1.40656187
50MP0003137_abnormal_impulse_conducting1.40314188
51MP0005330_cardiomyopathy1.37955486
52MP0006035_abnormal_mitochondrial_morpho1.37622842
53MP0003941_abnormal_skin_development1.37487441
54MP0009697_abnormal_copulation1.35053856
55MP0005332_abnormal_amino_acid1.34996938
56MP0005083_abnormal_biliary_tract1.34830261
57MP0000678_abnormal_parathyroid_gland1.34814966
58MP0008875_abnormal_xenobiotic_pharmacok1.34000616
59MP0002735_abnormal_chemical_nociception1.32863655
60MP0001968_abnormal_touch/_nociception1.31991658
61MP0002272_abnormal_nervous_system1.31916013
62MP0002909_abnormal_adrenal_gland1.31581742
63MP0000631_abnormal_neuroendocrine_gland1.30824516
64MP0002796_impaired_skin_barrier1.30217858
65MP0009745_abnormal_behavioral_response1.30099897
66MP0004270_analgesia1.29742636
67MP0003315_abnormal_perineum_morphology1.28249327
68MP0004019_abnormal_vitamin_homeostasis1.27858241
69MP0003718_maternal_effect1.27025382
70MP0000613_abnormal_salivary_gland1.24710655
71MP0002734_abnormal_mechanical_nocicepti1.23377059
72MP0000049_abnormal_middle_ear1.22862020
73MP0003724_increased_susceptibility_to1.21924026
74MP0004215_abnormal_myocardial_fiber1.20991134
75MP0001346_abnormal_lacrimal_gland1.19025616
76MP0005636_abnormal_mineral_homeostasis1.18387119
77MP0009643_abnormal_urine_homeostasis1.18320214
78MP0001486_abnormal_startle_reflex1.17410042
79MP0005408_hypopigmentation1.15707469
80MP0005084_abnormal_gallbladder_morpholo1.15172009
81MP0002233_abnormal_nose_morphology1.14695944
82MP0005360_urolithiasis1.10179827
83MP0008789_abnormal_olfactory_epithelium1.09666515
84MP0002098_abnormal_vibrissa_morphology1.09095471
85MP0000778_abnormal_nervous_system1.07313147
86MP0001986_abnormal_taste_sensitivity1.06806949
87MP0002090_abnormal_vision1.05849143
88MP0004036_abnormal_muscle_relaxation1.05572844
89MP0004924_abnormal_behavior1.05177713
90MP0005386_behavior/neurological_phenoty1.05177713
91MP0005365_abnormal_bile_salt1.05056125
92MP0002876_abnormal_thyroid_physiology1.04796209
93MP0000762_abnormal_tongue_morphology1.04779236
94MP0005646_abnormal_pituitary_gland1.03886991
95MP0002557_abnormal_social/conspecific_i1.03317057
96MP0000750_abnormal_muscle_regeneration1.02322384
97MP0004084_abnormal_cardiac_muscle1.00315574
98MP0002928_abnormal_bile_duct0.98109550
99MP0002572_abnormal_emotion/affect_behav0.96831022
100MP0003937_abnormal_limbs/digits/tail_de0.96502538
101MP0002148_abnormal_hypersensitivity_rea0.95357231
102MP0001970_abnormal_pain_threshold0.94814930
103MP0002282_abnormal_trachea_morphology0.94515627
104MP0008961_abnormal_basal_metabolism0.94184419
105MP0002184_abnormal_innervation0.93657001
106MP0005391_vision/eye_phenotype0.92868120
107MP0003828_pulmonary_edema0.92208957
108MP0003786_premature_aging0.91996536
109MP0001666_abnormal_nutrient_absorption0.91609398
110MP0005220_abnormal_exocrine_pancreas0.91248368
111MP0006072_abnormal_retinal_apoptosis0.89906011
112MP0001293_anophthalmia0.89199182
113MP0003755_abnormal_palate_morphology0.88784156
114MP0001485_abnormal_pinna_reflex0.87144190
115MP0001663_abnormal_digestive_system0.87033279
116MP0005248_abnormal_Harderian_gland0.86841165
117MP0002752_abnormal_somatic_nervous0.86019093
118MP0005195_abnormal_posterior_eye0.85625626
119MP0002938_white_spotting0.85309223
120MP0005501_abnormal_skin_physiology0.84917437
121MP0008058_abnormal_DNA_repair0.84622836
122MP0005423_abnormal_somatic_nervous0.83116414
123MP0000647_abnormal_sebaceous_gland0.82715158
124MP0002064_seizures0.82696590
125MP0005075_abnormal_melanosome_morpholog0.82580494
126MP0002249_abnormal_larynx_morphology0.81977916
127MP0003119_abnormal_digestive_system0.81926617
128MP0002653_abnormal_ependyma_morphology0.81695748
129MP0000026_abnormal_inner_ear0.81623132
130MP0000490_abnormal_crypts_of0.80384806
131MP0001905_abnormal_dopamine_level0.80129565
132MP0003283_abnormal_digestive_organ0.79242547
133MP0005381_digestive/alimentary_phenotyp0.78335812
134MP0005319_abnormal_enzyme/_coenzyme0.78320078
135MP0002733_abnormal_thermal_nociception0.77438070
136MP0006054_spinal_hemorrhage0.77366250
137MP0000751_myopathy0.77054939
138MP0004782_abnormal_surfactant_physiolog0.76815613
139MP0005584_abnormal_enzyme/coenzyme_acti0.76046923
140MP0006292_abnormal_olfactory_placode0.75724538
141MP0010094_abnormal_chromosome_stability0.74822963
142MP0004085_abnormal_heartbeat0.74587947
143MP0005171_absent_coat_pigmentation0.74424330
144MP0001929_abnormal_gametogenesis0.73936658
145MP0002069_abnormal_eating/drinking_beha0.73770584
146MP0005409_darkened_coat_color0.73477677
147MP0005266_abnormal_metabolism0.71999171
148MP0010386_abnormal_urinary_bladder0.71076343
149MP0004142_abnormal_muscle_tone0.70399164
150MP0000579_abnormal_nail_morphology0.69099853
151MP0002693_abnormal_pancreas_physiology0.68884831
152MP0000538_abnormal_urinary_bladder0.64769367
153MP0002972_abnormal_cardiac_muscle0.63790010
154MP0001756_abnormal_urination0.63787151
155MP0001944_abnormal_pancreas_morphology0.63588850
156MP0004147_increased_porphyrin_level0.62661261
157MP0004133_heterotaxia0.62388876
158MP0009250_abnormal_appendicular_skeleto0.61160185
159MP0008995_early_reproductive_senescence0.59459896
160MP0001542_abnormal_bone_strength0.59331915
161MP0001919_abnormal_reproductive_system0.58105396
162MP0000467_abnormal_esophagus_morphology0.57978424
163MP0002127_abnormal_cardiovascular_syste0.57872416

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.12553092
2Mitochondrial inheritance (HP:0001427)5.92711260
3Hepatocellular necrosis (HP:0001404)5.66317255
4Abnormal mitochondria in muscle tissue (HP:0008316)5.63799592
5Hepatic necrosis (HP:0002605)5.56522132
6Acute encephalopathy (HP:0006846)5.25052118
7Increased CSF lactate (HP:0002490)5.09360093
8Increased hepatocellular lipid droplets (HP:0006565)5.02625794
9Progressive macrocephaly (HP:0004481)4.95873590
10Reticulocytopenia (HP:0001896)4.81036535
11Lipid accumulation in hepatocytes (HP:0006561)4.79205575
12Abnormality of cells of the erythroid lineage (HP:0012130)4.67674832
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.40276165
14Renal Fanconi syndrome (HP:0001994)4.37449357
15Increased intramyocellular lipid droplets (HP:0012240)4.24635207
16Abnormal number of erythroid precursors (HP:0012131)4.21477693
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.20192450
18Decreased activity of mitochondrial respiratory chain (HP:0008972)4.20192450
19Abnormal hemoglobin (HP:0011902)4.12996914
20Macrocytic anemia (HP:0001972)4.10119992
21Cerebral edema (HP:0002181)4.07375331
22Increased muscle lipid content (HP:0009058)3.96832376
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.79453560
24Increased serum lactate (HP:0002151)3.71012683
25Exertional dyspnea (HP:0002875)3.70835496
26Respiratory failure (HP:0002878)3.70192119
27Medial flaring of the eyebrow (HP:0010747)3.61645720
28Exercise intolerance (HP:0003546)3.56579896
29Aplasia/Hypoplasia of the sacrum (HP:0008517)3.55356773
303-Methylglutaconic aciduria (HP:0003535)3.49824298
31Lactic acidosis (HP:0003128)3.48685681
32Pancreatic fibrosis (HP:0100732)3.34087418
33Pallor (HP:0000980)3.25836019
34Abnormality of urine glucose concentration (HP:0011016)3.16288439
35Glycosuria (HP:0003076)3.16288439
36Hypothermia (HP:0002045)3.15181964
37Abnormality of renal resorption (HP:0011038)3.14526713
38Pancreatic cysts (HP:0001737)3.10878960
39Respiratory difficulties (HP:0002880)3.09712952
40True hermaphroditism (HP:0010459)3.07109074
41Gait imbalance (HP:0002141)3.00365323
42Congenital primary aphakia (HP:0007707)2.99307580
43Optic disc pallor (HP:0000543)2.87147908
44Abnormality of midbrain morphology (HP:0002418)2.84327009
45Molar tooth sign on MRI (HP:0002419)2.84327009
46Nephronophthisis (HP:0000090)2.82123330
47Hyperphosphaturia (HP:0003109)2.79536149
48Leukodystrophy (HP:0002415)2.78494258
49Lethargy (HP:0001254)2.78193126
50Nephrogenic diabetes insipidus (HP:0009806)2.74564202
51Abnormality of the labia minora (HP:0012880)2.69726958
52Generalized aminoaciduria (HP:0002909)2.69096770
53CNS demyelination (HP:0007305)2.68471722
54Dicarboxylic aciduria (HP:0003215)2.61464238
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61464238
56Limb dystonia (HP:0002451)2.57327919
57Genital tract atresia (HP:0001827)2.53986784
58Palpitations (HP:0001962)2.44362193
59Vaginal atresia (HP:0000148)2.37782934
60Concave nail (HP:0001598)2.32878284
61Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32644181
62Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.31746914
63Polyphagia (HP:0002591)2.29462563
64Abnormal urine phosphate concentration (HP:0012599)2.28936533
65Hypoglycemic coma (HP:0001325)2.26579987
66Poor suck (HP:0002033)2.26123374
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.23807119
68Microvesicular hepatic steatosis (HP:0001414)2.22707719
69Abnormality of the renal medulla (HP:0100957)2.19076232
70Short tibia (HP:0005736)2.18681244
71Intestinal atresia (HP:0011100)2.18383969
72Aplasia/hypoplasia of the uterus (HP:0008684)2.17551870
73Abnormality of glycolysis (HP:0004366)2.16596070
74Increased serum pyruvate (HP:0003542)2.16596070
75Degeneration of anterior horn cells (HP:0002398)2.13277629
76Abnormality of the anterior horn cell (HP:0006802)2.13277629
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13122177
78Abnormal protein N-linked glycosylation (HP:0012347)2.13122177
79Abnormal protein glycosylation (HP:0012346)2.13122177
80Abnormal glycosylation (HP:0012345)2.13122177
81Abnormality of vitamin B metabolism (HP:0004340)2.11269205
82Sudden death (HP:0001699)2.09427257
83Type I transferrin isoform profile (HP:0003642)2.09021060
84Testicular atrophy (HP:0000029)2.06940116
85Abnormality of fatty-acid metabolism (HP:0004359)2.06880130
86Methylmalonic aciduria (HP:0012120)2.03471216
87Renal tubular dysfunction (HP:0000124)2.03399516
88Postaxial hand polydactyly (HP:0001162)2.02503118
89Nausea (HP:0002018)2.01179352
90Oral leukoplakia (HP:0002745)2.00105989
91Occipital encephalocele (HP:0002085)1.99997050
92Ventricular tachycardia (HP:0004756)1.98781815
93Emotional lability (HP:0000712)1.98670654
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.97595115
95Aplastic anemia (HP:0001915)1.96049290
96Amniotic constriction ring (HP:0009775)1.95898994
97Abnormality of placental membranes (HP:0011409)1.95898994
98Abolished electroretinogram (ERG) (HP:0000550)1.93074786
99Supernumerary spleens (HP:0009799)1.92767291
100Progressive muscle weakness (HP:0003323)1.89674327
101Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89313313
102Sclerocornea (HP:0000647)1.88672163
103Stenosis of the external auditory canal (HP:0000402)1.87638671
104Calf muscle hypertrophy (HP:0008981)1.87006861
105Muscle hypertrophy of the lower extremities (HP:0008968)1.86638306
106Vomiting (HP:0002013)1.86359644
107Abnormal respiratory motile cilium morphology (HP:0005938)1.86104944
108Abnormal respiratory epithelium morphology (HP:0012253)1.86104944
109Delayed gross motor development (HP:0002194)1.85816968
110Congenital ichthyosiform erythroderma (HP:0007431)1.81550249
111Muscular hypotonia of the trunk (HP:0008936)1.81215379
112Specific learning disability (HP:0001328)1.80600094
113Congenital sensorineural hearing impairment (HP:0008527)1.79836256
114Abnormal ciliary motility (HP:0012262)1.79704785
115Ventricular fibrillation (HP:0001663)1.79623818
116Abnormality of serum amino acid levels (HP:0003112)1.79003981
117Cerebral hypomyelination (HP:0006808)1.78604217
118Decreased testicular size (HP:0008734)1.78332144
119Poor coordination (HP:0002370)1.77965897
120Chronic hepatic failure (HP:0100626)1.76987017
121Postaxial foot polydactyly (HP:0001830)1.76568921
122Abnormality of methionine metabolism (HP:0010901)1.76305521
123Abnormality of the vitamin B12 metabolism (HP:0004341)1.76065573
124Partial duplication of thumb phalanx (HP:0009944)1.74333064
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74028114
126Abnormality of alanine metabolism (HP:0010916)1.74028114
127Hyperalaninemia (HP:0003348)1.74028114
128Hyperinsulinemic hypoglycemia (HP:0000825)1.73818880
129Broad foot (HP:0001769)1.73101601
130Renal cortical cysts (HP:0000803)1.73001121
13111 pairs of ribs (HP:0000878)1.72110570
132Methylmalonic acidemia (HP:0002912)1.70888254
133Male pseudohermaphroditism (HP:0000037)1.70871885
134Abnormal respiratory motile cilium physiology (HP:0012261)1.70837091
135Attenuation of retinal blood vessels (HP:0007843)1.70092039
136Proximal tubulopathy (HP:0000114)1.69093217
137Progressive external ophthalmoplegia (HP:0000590)1.68769138
138Anencephaly (HP:0002323)1.68417146
139Rough bone trabeculation (HP:0100670)1.67572808
140Hyperglycinemia (HP:0002154)1.66526470
141Gliosis (HP:0002171)1.65887965
142Hypoplasia of the uterus (HP:0000013)1.65860199
143Parakeratosis (HP:0001036)1.65852246
144Sparse eyelashes (HP:0000653)1.64474154
145Secondary amenorrhea (HP:0000869)1.63938876
146Hyperglycinuria (HP:0003108)1.63530289
147Redundant skin (HP:0001582)1.63273139
148Abnormal pupillary function (HP:0007686)1.62683152
149Ridged nail (HP:0001807)1.61311083
150Depressed nasal ridge (HP:0000457)1.60715788
151Dilated cardiomyopathy (HP:0001644)1.60593736
152X-linked dominant inheritance (HP:0001423)1.60229890
153Myoglobinuria (HP:0002913)1.59149144
154Ketoacidosis (HP:0001993)1.58133128
155Partial duplication of the phalanx of hand (HP:0009999)1.58053992
156Congenital, generalized hypertrichosis (HP:0004540)1.56956116
157Blindness (HP:0000618)1.54993798
158Prolonged QT interval (HP:0001657)1.50395138
159Rhabdomyolysis (HP:0003201)1.49905799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.77838165
2STK164.08886493
3NME23.93343868
4MAP4K23.34343894
5WNK32.96096408
6BCKDK2.94634668
7TRIM282.80553791
8IRAK32.78363946
9NME12.76110135
10PBK2.58680027
11FRK2.47844722
12MAP3K122.41947002
13ERBB32.38517694
14MAP3K42.24849089
15BUB12.13935603
16EIF2AK12.05542274
17MYLK1.98733309
18VRK11.98006533
19VRK21.87621881
20MAP2K71.81160702
21MST41.79586028
22PIM21.79172890
23LMTK21.76473467
24WNK41.75332730
25STK391.74497723
26GRK11.74188617
27IRAK41.71678000
28PLK21.66105687
29NEK11.64069558
30NUAK11.63538419
31ZAK1.60262512
32MAPK151.54707737
33CDK191.53985344
34MAP2K21.53683152
35MAPK131.53567531
36SRPK11.50850685
37IRAK11.43132424
38CSNK1G31.39604269
39BRAF1.38882980
40TESK21.37464556
41CSNK1G21.37192479
42MAP3K111.34830447
43MARK11.29745437
44PIK3CG1.29555945
45PLK31.28599012
46CSNK1G11.27849929
47OBSCN1.27721088
48EPHA41.23409153
49PLK41.22525207
50PAK31.19027104
51IRAK21.18929011
52CSNK1A1L1.15369434
53LIMK11.14781589
54RPS6KB21.06791629
55TESK11.06487494
56WEE11.05887553
57GRK71.04267554
58NEK91.01845592
59STK38L0.96514662
60MAPKAPK30.96153531
61DAPK30.95986979
62MKNK20.93316668
63PRKG20.92332147
64TSSK60.91880095
65PRKCE0.91294832
66OXSR10.88060404
67AURKA0.87504916
68MKNK10.86980847
69ILK0.85707136
70MINK10.85558839
71AURKB0.81862470
72PRKCG0.80937546
73RPS6KA50.80737925
74MAP3K30.78579151
75BRSK20.76162333
76BMPR1B0.73607457
77EPHB20.72932028
78BCR0.72485143
79ABL20.71899135
80CAMK2D0.71237078
81BLK0.70222516
82CAMK2G0.68371334
83CASK0.68330943
84INSRR0.68256248
85CSNK2A10.68085766
86FGFR20.68061641
87DYRK30.67477776
88ACVR1B0.66779590
89MAP2K40.66308233
90DYRK20.65713790
91EIF2AK30.65435311
92TEC0.65118648
93PASK0.65030320
94MUSK0.64411861
95PRKCI0.63280970
96MAPKAPK50.63041291
97CCNB10.62411871
98MAP2K60.60359008
99TGFBR10.59953141
100MST1R0.59551675
101IKBKB0.59022346
102PKN10.56788255
103PLK10.55868989
104KDR0.54782495
105SIK30.54472066
106CAMK2A0.54035304
107PDK20.53793555
108TIE10.53443965
109PHKG10.52758603
110PHKG20.52758603
111CSNK2A20.52036889
112PINK10.51022025
113DYRK1B0.50522345
114PNCK0.50066043
115CAMK2B0.49216220
116BMPR20.48781070
117CDK80.48172842
118STK40.47490811
119ADRBK20.47124789
120CDK70.46646379
121ARAF0.46368792
122FLT30.44688750
123LRRK20.43477207
124ADRBK10.43095031
125EIF2AK20.42705811
126FER0.42687639
127NLK0.42268397
128RPS6KL10.40803402
129RPS6KC10.40803402
130EPHA20.40235544
131MAP3K50.39447186
132TNIK0.39322586
133CSNK1A10.37826278
134UHMK10.36097948
135TTK0.35186103
136MAPK40.35105702
137RPS6KA40.34629449
138TRPM70.34537593
139BTK0.34480679
140IKBKE0.33804179
141PRKACA0.33463909
142BRSK10.31074453
143PRKG10.30447936
144CDK140.29917511
145ATM0.28327442
146PRKACB0.28138205
147DAPK10.27509403

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.76888347
2Oxidative phosphorylation_Homo sapiens_hsa001904.85007975
3Parkinsons disease_Homo sapiens_hsa050124.24826320
4Protein export_Homo sapiens_hsa030603.17324946
5Huntingtons disease_Homo sapiens_hsa050163.06980257
6Alzheimers disease_Homo sapiens_hsa050103.02183819
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.90965470
8Proteasome_Homo sapiens_hsa030502.77410437
9RNA polymerase_Homo sapiens_hsa030202.54642013
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04848296
11Cardiac muscle contraction_Homo sapiens_hsa042601.96192190
12Homologous recombination_Homo sapiens_hsa034401.81589656
13DNA replication_Homo sapiens_hsa030301.81347337
14Pyrimidine metabolism_Homo sapiens_hsa002401.73366845
15Folate biosynthesis_Homo sapiens_hsa007901.71990554
16Phototransduction_Homo sapiens_hsa047441.60710025
17Fatty acid elongation_Homo sapiens_hsa000621.56701874
18Mismatch repair_Homo sapiens_hsa034301.56142067
19Collecting duct acid secretion_Homo sapiens_hsa049661.45646906
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.43654637
21Sulfur metabolism_Homo sapiens_hsa009201.43456244
22Sulfur relay system_Homo sapiens_hsa041221.42007577
23Spliceosome_Homo sapiens_hsa030401.35879673
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34470960
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34232853
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32592388
27Glutathione metabolism_Homo sapiens_hsa004801.27707344
28Propanoate metabolism_Homo sapiens_hsa006401.27452448
29Nicotine addiction_Homo sapiens_hsa050331.26571283
30Nucleotide excision repair_Homo sapiens_hsa034201.18811743
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17027687
32Arachidonic acid metabolism_Homo sapiens_hsa005901.16359348
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12534023
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11471047
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11432236
36Base excision repair_Homo sapiens_hsa034101.09537697
37Fatty acid degradation_Homo sapiens_hsa000711.08479414
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08455408
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00790396
40Basal transcription factors_Homo sapiens_hsa030221.00128809
41Chemical carcinogenesis_Homo sapiens_hsa052040.99283528
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99178493
43Peroxisome_Homo sapiens_hsa041460.99169766
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98072184
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97702732
46Metabolic pathways_Homo sapiens_hsa011000.95719098
47Pyruvate metabolism_Homo sapiens_hsa006200.94972741
48Fanconi anemia pathway_Homo sapiens_hsa034600.94749234
49Butanoate metabolism_Homo sapiens_hsa006500.93921315
50Linoleic acid metabolism_Homo sapiens_hsa005910.93421168
51Purine metabolism_Homo sapiens_hsa002300.91561823
52Histidine metabolism_Homo sapiens_hsa003400.86962398
53One carbon pool by folate_Homo sapiens_hsa006700.85433081
54Other glycan degradation_Homo sapiens_hsa005110.84139006
55Tryptophan metabolism_Homo sapiens_hsa003800.83949728
56GABAergic synapse_Homo sapiens_hsa047270.83075288
57Vitamin B6 metabolism_Homo sapiens_hsa007500.82985114
58Carbon metabolism_Homo sapiens_hsa012000.82052720
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81715882
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80396767
61beta-Alanine metabolism_Homo sapiens_hsa004100.79151787
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.79082735
63Arginine and proline metabolism_Homo sapiens_hsa003300.79073586
64Tyrosine metabolism_Homo sapiens_hsa003500.78835463
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77792480
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77677951
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76281393
68Phenylalanine metabolism_Homo sapiens_hsa003600.74495966
69Retinol metabolism_Homo sapiens_hsa008300.74003459
70RNA degradation_Homo sapiens_hsa030180.73850677
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73248690
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71093062
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.68988604
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66514983
75Nitrogen metabolism_Homo sapiens_hsa009100.66127576
76N-Glycan biosynthesis_Homo sapiens_hsa005100.62617381
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61344804
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.59167420
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58249062
80Synaptic vesicle cycle_Homo sapiens_hsa047210.57312305
81Fatty acid metabolism_Homo sapiens_hsa012120.56853496
82Pentose phosphate pathway_Homo sapiens_hsa000300.56815042
83Dopaminergic synapse_Homo sapiens_hsa047280.55844589
84Morphine addiction_Homo sapiens_hsa050320.54962628
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53795712
86RNA transport_Homo sapiens_hsa030130.50729977
87Taste transduction_Homo sapiens_hsa047420.50064495
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49066366
89* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48344738
90Circadian rhythm_Homo sapiens_hsa047100.48304571
91* Oocyte meiosis_Homo sapiens_hsa041140.48007751
92Sphingolipid metabolism_Homo sapiens_hsa006000.47404095
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.47067351
94Serotonergic synapse_Homo sapiens_hsa047260.45884001
95Olfactory transduction_Homo sapiens_hsa047400.45468884
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44571002
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44387541
98Fat digestion and absorption_Homo sapiens_hsa049750.43732801
99Circadian entrainment_Homo sapiens_hsa047130.43389082
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.43311548
101Galactose metabolism_Homo sapiens_hsa000520.42377283
102Hedgehog signaling pathway_Homo sapiens_hsa043400.41916611
103Systemic lupus erythematosus_Homo sapiens_hsa053220.41902438
104Starch and sucrose metabolism_Homo sapiens_hsa005000.41709057
105Non-homologous end-joining_Homo sapiens_hsa034500.41654576
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40831304
107Steroid biosynthesis_Homo sapiens_hsa001000.40803940
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40246951
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39835849
110Cocaine addiction_Homo sapiens_hsa050300.39021688
111Selenocompound metabolism_Homo sapiens_hsa004500.38677768
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37952975
113Fructose and mannose metabolism_Homo sapiens_hsa000510.36972681
114Vibrio cholerae infection_Homo sapiens_hsa051100.35945657
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34566791
116Biosynthesis of amino acids_Homo sapiens_hsa012300.32617545
117Regulation of autophagy_Homo sapiens_hsa041400.26089582
118Ether lipid metabolism_Homo sapiens_hsa005650.25648100
119Caffeine metabolism_Homo sapiens_hsa002320.16594981
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12510927
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11819751
122Asthma_Homo sapiens_hsa053100.11768792
123PPAR signaling pathway_Homo sapiens_hsa033200.10496520
124Epstein-Barr virus infection_Homo sapiens_hsa051690.10303380
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.09932609

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