ANAPC15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.87805500
2protein complex biogenesis (GO:0070271)5.19505824
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.10218734
4ATP synthesis coupled proton transport (GO:0015986)5.10218734
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.05375573
6mitochondrial respiratory chain complex I assembly (GO:0032981)5.05375573
7NADH dehydrogenase complex assembly (GO:0010257)5.05375573
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.96172847
9mitochondrial respiratory chain complex assembly (GO:0033108)4.92191447
10mitotic metaphase plate congression (GO:0007080)4.87467464
11DNA replication checkpoint (GO:0000076)4.86997553
12protein localization to kinetochore (GO:0034501)4.73624210
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.64301959
14DNA strand elongation involved in DNA replication (GO:0006271)4.59458368
15telomere maintenance via semi-conservative replication (GO:0032201)4.55197235
16respiratory electron transport chain (GO:0022904)4.47638306
17electron transport chain (GO:0022900)4.44385260
18DNA replication initiation (GO:0006270)4.43274699
19respiratory chain complex IV assembly (GO:0008535)4.37048154
20telomere maintenance via recombination (GO:0000722)4.36890007
21chaperone-mediated protein transport (GO:0072321)4.33571893
22DNA strand elongation (GO:0022616)4.33405059
23protein localization to chromosome, centromeric region (GO:0071459)4.31795368
24CENP-A containing nucleosome assembly (GO:0034080)4.31254021
25chromatin remodeling at centromere (GO:0031055)4.23616286
26kinetochore organization (GO:0051383)4.19670542
27metaphase plate congression (GO:0051310)4.17745269
28cytochrome complex assembly (GO:0017004)4.12193720
29mitotic recombination (GO:0006312)4.12109639
30kinetochore assembly (GO:0051382)4.08375792
31attachment of spindle microtubules to kinetochore (GO:0008608)4.02049376
32nucleobase biosynthetic process (GO:0046112)4.00689786
33purine nucleobase biosynthetic process (GO:0009113)3.99295662
34DNA replication-independent nucleosome assembly (GO:0006336)3.95157155
35DNA replication-independent nucleosome organization (GO:0034724)3.95157155
36mitotic sister chromatid segregation (GO:0000070)3.92847263
37maturation of SSU-rRNA (GO:0030490)3.90819966
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.88493741
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.82767817
40establishment of chromosome localization (GO:0051303)3.81844205
41DNA deamination (GO:0045006)3.80567145
42regulation of spindle organization (GO:0090224)3.79186591
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.78519235
44mitotic chromosome condensation (GO:0007076)3.78061810
45protein neddylation (GO:0045116)3.77883961
46DNA replication-dependent nucleosome assembly (GO:0006335)3.76600592
47DNA replication-dependent nucleosome organization (GO:0034723)3.76600592
48mitotic nuclear envelope disassembly (GO:0007077)3.74608466
49ribosomal small subunit assembly (GO:0000028)3.73692838
50formation of translation preinitiation complex (GO:0001731)3.69044725
51telomere maintenance via telomere lengthening (GO:0010833)3.68511857
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.67647258
53histone exchange (GO:0043486)3.66748828
54ribosome biogenesis (GO:0042254)3.65586391
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.62774626
56platelet dense granule organization (GO:0060155)3.60091952
57pseudouridine synthesis (GO:0001522)3.55133223
58spindle checkpoint (GO:0031577)3.49683802
59proteasome assembly (GO:0043248)3.49274900
60DNA unwinding involved in DNA replication (GO:0006268)3.47846487
61ribonucleoprotein complex biogenesis (GO:0022613)3.44812407
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44651582
63sister chromatid segregation (GO:0000819)3.44599352
64ribosome assembly (GO:0042255)3.44526792
65membrane disassembly (GO:0030397)3.44285372
66nuclear envelope disassembly (GO:0051081)3.44285372
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.41628912
68regulation of cellular amino acid metabolic process (GO:0006521)3.39656890
69spliceosomal snRNP assembly (GO:0000387)3.37652686
70ribosomal large subunit biogenesis (GO:0042273)3.37216611
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35825568
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35825568
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34244006
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34244006
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34244006
76meiotic chromosome segregation (GO:0045132)3.33339976
77transcription-coupled nucleotide-excision repair (GO:0006283)3.32444503
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32029874
79somatic hypermutation of immunoglobulin genes (GO:0016446)3.32029874
80positive regulation of chromosome segregation (GO:0051984)3.31926558
81cullin deneddylation (GO:0010388)3.30910446
82negative regulation of ligase activity (GO:0051352)3.30871913
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.30871913
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.29757045
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29738379
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29738379
87regulation of double-strand break repair via homologous recombination (GO:0010569)3.28603037
88regulation of chromosome segregation (GO:0051983)3.28073031
89regulation of nuclear cell cycle DNA replication (GO:0033262)3.27469011
90regulation of mitochondrial translation (GO:0070129)3.27404670
91negative regulation of chromosome segregation (GO:0051985)3.24980711
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24311538
93rRNA processing (GO:0006364)3.23112640
94negative regulation of mitotic sister chromatid separation (GO:2000816)3.22696047
95negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22696047
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22696047
97negative regulation of sister chromatid segregation (GO:0033046)3.22696047
98rRNA modification (GO:0000154)3.22355880
99chromosome segregation (GO:0007059)3.22261563
100nuclear pore organization (GO:0006999)3.21799767
101replication fork processing (GO:0031297)3.20440948
102spindle assembly checkpoint (GO:0071173)3.20397956
103regulation of mitotic metaphase/anaphase transition (GO:0030071)3.20285612
104signal transduction involved in cell cycle checkpoint (GO:0072395)3.19737528
105protein-cofactor linkage (GO:0018065)3.19364072
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.19166915
107peptidyl-histidine modification (GO:0018202)3.18832048
108signal transduction involved in DNA integrity checkpoint (GO:0072401)3.18376036
109signal transduction involved in DNA damage checkpoint (GO:0072422)3.18376036
110mitotic spindle checkpoint (GO:0071174)3.17626988
111ribosomal small subunit biogenesis (GO:0042274)3.16282251
112termination of RNA polymerase III transcription (GO:0006386)3.14872367
113transcription elongation from RNA polymerase III promoter (GO:0006385)3.14872367
114protein localization to chromosome (GO:0034502)3.14614589
115spliceosomal complex assembly (GO:0000245)3.14268552
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13888196
117rRNA metabolic process (GO:0016072)3.13789091
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13534327
119protein deneddylation (GO:0000338)3.12550738
120mitotic spindle assembly checkpoint (GO:0007094)3.12541684
121maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12282349
122water-soluble vitamin biosynthetic process (GO:0042364)3.10558884
123regulation of mitotic spindle organization (GO:0060236)3.10304143
124viral transcription (GO:0019083)3.10256388
125protein targeting to mitochondrion (GO:0006626)3.09709795
126IMP biosynthetic process (GO:0006188)3.09123537
127translational termination (GO:0006415)3.07672044
128protein K6-linked ubiquitination (GO:0085020)3.06853964
129hydrogen ion transmembrane transport (GO:1902600)3.03901803
130DNA double-strand break processing (GO:0000729)3.03747001
131G1/S transition of mitotic cell cycle (GO:0000082)3.03402992
132cell cycle G1/S phase transition (GO:0044843)3.03402992
133translational initiation (GO:0006413)3.02236984
134folic acid-containing compound biosynthetic process (GO:0009396)3.01943311
1357-methylguanosine mRNA capping (GO:0006370)3.01579664
136response to pheromone (GO:0019236)3.01499870
137maturation of 5.8S rRNA (GO:0000460)3.01135421
138establishment of protein localization to mitochondrion (GO:0072655)3.00826765
139inner mitochondrial membrane organization (GO:0007007)3.00653130
140regulation of mitotic sister chromatid separation (GO:0010965)2.99312390
141regulation of mitotic sister chromatid segregation (GO:0033047)2.99312390
142regulation of sister chromatid segregation (GO:0033045)2.99312390
143base-excision repair, AP site formation (GO:0006285)2.99213241
144mannosylation (GO:0097502)2.98737001
145chromatin assembly or disassembly (GO:0006333)2.98382074
146positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97387272
147nuclear pore complex assembly (GO:0051292)2.97234590
148RNA capping (GO:0036260)2.96009621
1497-methylguanosine RNA capping (GO:0009452)2.96009621
150termination of RNA polymerase I transcription (GO:0006363)2.96002396
151ATP biosynthetic process (GO:0006754)2.95206846
152DNA damage response, detection of DNA damage (GO:0042769)2.93383411
153purine nucleoside triphosphate biosynthetic process (GO:0009145)2.91804061
154protein localization to mitochondrion (GO:0070585)2.89923580
155tRNA processing (GO:0008033)2.89390591
156purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89320697
157ubiquinone biosynthetic process (GO:0006744)2.88910604
158proton transport (GO:0015992)2.87005136
159rRNA methylation (GO:0031167)2.84426582
160positive regulation of ligase activity (GO:0051351)2.82681925
161behavioral response to nicotine (GO:0035095)2.81771338
162intracellular protein transmembrane import (GO:0044743)2.81299310
163preassembly of GPI anchor in ER membrane (GO:0016254)2.80938781
164deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80076201
165hydrogen transport (GO:0006818)2.79838482
166sequestering of actin monomers (GO:0042989)2.78099991
167cellular component biogenesis (GO:0044085)2.78004574
168negative regulation of telomere maintenance (GO:0032205)2.77791214
169translation (GO:0006412)2.77698488
170recombinational repair (GO:0000725)2.76176502
171DNA catabolic process, exonucleolytic (GO:0000738)2.75706842
172pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75637150
173oxidative phosphorylation (GO:0006119)2.74211241
174double-strand break repair via homologous recombination (GO:0000724)2.73259204
175GTP biosynthetic process (GO:0006183)2.70681225
176DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.68195678
177SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.66654734
178cotranslational protein targeting to membrane (GO:0006613)2.65941422
179deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.63791872
180mitochondrial RNA metabolic process (GO:0000959)2.63682910
181mitochondrial transport (GO:0006839)2.61793944
182protein targeting to ER (GO:0045047)2.61283486
183ubiquinone metabolic process (GO:0006743)2.60057785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.49979224
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.59461088
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.10057912
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.86224804
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48783784
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.45723234
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34419827
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.12083378
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.01601910
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98085169
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.94831568
12ZNF274_21170338_ChIP-Seq_K562_Hela2.92874905
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90699511
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86128318
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78516722
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75778271
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.60212584
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35392587
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35157101
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34419227
21XRN2_22483619_ChIP-Seq_HELA_Human2.34011490
22VDR_22108803_ChIP-Seq_LS180_Human2.31891131
23VDR_23849224_ChIP-Seq_CD4+_Human2.28467794
24AR_21909140_ChIP-Seq_LNCAP_Human2.26485083
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17814967
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17038749
27E2F1_21310950_ChIP-Seq_MCF-7_Human2.03825631
28DCP1A_22483619_ChIP-Seq_HELA_Human2.02450377
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98575095
30FOXP3_21729870_ChIP-Seq_TREG_Human1.98311771
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96655595
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92762268
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90819099
34GABP_19822575_ChIP-Seq_HepG2_Human1.90713617
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90204419
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88328322
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82117809
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81123387
39TTF2_22483619_ChIP-Seq_HELA_Human1.80744072
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79378831
41EWS_26573619_Chip-Seq_HEK293_Human1.77200974
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76692817
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73075087
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71720072
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67689045
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.67208474
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62671505
48ELK1_19687146_ChIP-ChIP_HELA_Human1.62436156
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60661092
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59522324
51CIITA_25753668_ChIP-Seq_RAJI_Human1.58616691
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57884600
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53083523
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46889662
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.46630893
56TP53_22573176_ChIP-Seq_HFKS_Human1.45687722
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44758519
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.44402677
59KDM5A_27292631_Chip-Seq_BREAST_Human1.43282053
60IGF1R_20145208_ChIP-Seq_DFB_Human1.43205483
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.42623239
62FUS_26573619_Chip-Seq_HEK293_Human1.42519583
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40643379
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36206561
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35741667
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34125462
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33762030
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30610996
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.30294117
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27945149
71MYC_22102868_ChIP-Seq_BL_Human1.27269835
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26566604
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26340573
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24354504
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23811431
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22767832
77P300_19829295_ChIP-Seq_ESCs_Human1.22584580
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22017218
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21287766
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20630696
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20251313
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18587267
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18091866
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17958258
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17471831
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17297703
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16400467
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15262730
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14753074
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12847932
91TFEB_21752829_ChIP-Seq_HELA_Human1.10827934
92IRF1_19129219_ChIP-ChIP_H3396_Human1.10555659
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10090941
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09777812
95FOXA1_25329375_ChIP-Seq_VCAP_Human1.09777812
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08112197
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06913447
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06784612
99AR_20517297_ChIP-Seq_VCAP_Human1.05831311
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01678990
101* SPI1_23547873_ChIP-Seq_NB4_Human1.01323592
102ER_23166858_ChIP-Seq_MCF-7_Human1.01178219
103NANOG_19829295_ChIP-Seq_ESCs_Human1.00734814
104SOX2_19829295_ChIP-Seq_ESCs_Human1.00734814
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99612175
106TAF15_26573619_Chip-Seq_HEK293_Human0.98920281
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96882390
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96467678
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96229363
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95848160
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.95487246
112MYC_18940864_ChIP-ChIP_HL60_Human0.95278886
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95203916
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94580590
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94065511
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93987123
117NCOR_22424771_ChIP-Seq_293T_Human0.93296552
118ELK1_22589737_ChIP-Seq_MCF10A_Human0.92342232
119NANOG_16153702_ChIP-ChIP_HESCs_Human0.91266443
120PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89142480
121GBX2_23144817_ChIP-Seq_PC3_Human0.87865424
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87623901
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86151189
124SALL1_21062744_ChIP-ChIP_HESCs_Human0.85203620
125GATA3_21878914_ChIP-Seq_MCF-7_Human0.85115378
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84867549
127HTT_18923047_ChIP-ChIP_STHdh_Human0.84444493
128VDR_21846776_ChIP-Seq_THP-1_Human0.83785896
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.82263684
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82068358
131CBP_20019798_ChIP-Seq_JUKART_Human0.82068358
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81256543
133NFE2_27457419_Chip-Seq_LIVER_Mouse0.80975121
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80623504
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79974289
136NOTCH1_21737748_ChIP-Seq_TLL_Human0.75682888
137FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74651321
138NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74522297
139CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74437048
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72133965
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.71432192
142IRF8_21731497_ChIP-ChIP_J774_Mouse0.71385864
143TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69419537
144HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69392162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.34747308
2MP0010094_abnormal_chromosome_stability5.08734063
3MP0003111_abnormal_nucleus_morphology4.99873334
4MP0008057_abnormal_DNA_replication4.51711415
5MP0004957_abnormal_blastocyst_morpholog4.44557249
6MP0003077_abnormal_cell_cycle4.43221474
7MP0008058_abnormal_DNA_repair3.76156692
8MP0008007_abnormal_cellular_replicative3.11317771
9MP0000372_irregular_coat_pigmentation2.95302109
10MP0008932_abnormal_embryonic_tissue2.76253749
11MP0008877_abnormal_DNA_methylation2.52417454
12MP0001730_embryonic_growth_arrest2.45875321
13MP0002736_abnormal_nociception_after2.30065912
14MP0000350_abnormal_cell_proliferation2.26292704
15MP0002837_dystrophic_cardiac_calcinosis2.25168553
16MP0010307_abnormal_tumor_latency2.21697179
17MP0003718_maternal_effect2.20820355
18MP0003786_premature_aging2.19594586
19MP0002938_white_spotting2.19041243
20MP0002396_abnormal_hematopoietic_system2.18456542
21MP0006072_abnormal_retinal_apoptosis2.12646668
22MP0003136_yellow_coat_color2.09391719
23MP0003123_paternal_imprinting2.06734164
24MP0005551_abnormal_eye_electrophysiolog1.94153602
25MP0001529_abnormal_vocalization1.91732245
26MP0005084_abnormal_gallbladder_morpholo1.87407620
27MP0004147_increased_porphyrin_level1.87016470
28MP0003195_calcinosis1.86225558
29MP0008872_abnormal_physiological_respon1.84839264
30MP0001968_abnormal_touch/_nociception1.82750039
31MP0005380_embryogenesis_phenotype1.74115629
32MP0001672_abnormal_embryogenesis/_devel1.74115629
33MP0001697_abnormal_embryo_size1.71245738
34MP0008995_early_reproductive_senescence1.69171333
35MP0002163_abnormal_gland_morphology1.66951224
36MP0003880_abnormal_central_pattern1.66245225
37MP0003011_delayed_dark_adaptation1.61841832
38MP0002277_abnormal_respiratory_mucosa1.61705932
39MP0000313_abnormal_cell_death1.58895944
40MP0003646_muscle_fatigue1.57672762
41MP0005253_abnormal_eye_physiology1.55806725
42MP0000490_abnormal_crypts_of1.53567909
43MP0002080_prenatal_lethality1.52532707
44MP0002210_abnormal_sex_determination1.51198882
45MP0003984_embryonic_growth_retardation1.50705255
46MP0004142_abnormal_muscle_tone1.50257838
47MP0001905_abnormal_dopamine_level1.47308629
48MP0002019_abnormal_tumor_incidence1.47066065
49MP0002088_abnormal_embryonic_growth/wei1.46786093
50MP0002085_abnormal_embryonic_tissue1.46266381
51MP0009046_muscle_twitch1.43047114
52MP0005646_abnormal_pituitary_gland1.39361572
53MP0003567_abnormal_fetal_cardiomyocyte1.33362618
54MP0002095_abnormal_skin_pigmentation1.33271499
55MP0001145_abnormal_male_reproductive1.33104081
56MP0003787_abnormal_imprinting1.33084839
57MP0008875_abnormal_xenobiotic_pharmacok1.31685917
58MP0005645_abnormal_hypothalamus_physiol1.30302333
59MP0001929_abnormal_gametogenesis1.30109843
60MP0009379_abnormal_foot_pigmentation1.30010552
61MP0001485_abnormal_pinna_reflex1.29893070
62MP0004808_abnormal_hematopoietic_stem1.26831867
63MP0008789_abnormal_olfactory_epithelium1.26343092
64MP0009333_abnormal_splenocyte_physiolog1.26159380
65MP0002084_abnormal_developmental_patter1.25937601
66MP0001984_abnormal_olfaction1.25695969
67MP0005379_endocrine/exocrine_gland_phen1.25240877
68MP0002086_abnormal_extraembryonic_tissu1.25094661
69MP0003315_abnormal_perineum_morphology1.21461442
70MP0006292_abnormal_olfactory_placode1.21117367
71MP0009745_abnormal_behavioral_response1.19787470
72MP0000631_abnormal_neuroendocrine_gland1.18571762
73MP0001986_abnormal_taste_sensitivity1.14951556
74MP0000653_abnormal_sex_gland1.14627923
75MP0005397_hematopoietic_system_phenotyp1.13519006
76MP0001545_abnormal_hematopoietic_system1.13519006
77MP0010352_gastrointestinal_tract_polyps1.12914331
78MP0002234_abnormal_pharynx_morphology1.11054093
79MP0002102_abnormal_ear_morphology1.10986126
80MP0002398_abnormal_bone_marrow1.10720685
81MP0003121_genomic_imprinting1.09407057
82MP0006276_abnormal_autonomic_nervous1.08439173
83MP0001919_abnormal_reproductive_system1.08265793
84MP0002751_abnormal_autonomic_nervous1.06235326
85MP0005076_abnormal_cell_differentiation1.03859477
86MP0005410_abnormal_fertilization1.03784752
87MP0000703_abnormal_thymus_morphology1.03509010
88MP0001764_abnormal_homeostasis1.02332475
89MP0000689_abnormal_spleen_morphology1.01652977
90MP0008260_abnormal_autophagy1.01377842
91MP0000358_abnormal_cell_content/1.01365534
92MP0004197_abnormal_fetal_growth/weight/1.00582362
93MP0002638_abnormal_pupillary_reflex1.00216464
94MP0009697_abnormal_copulation1.00169694
95MP0002722_abnormal_immune_system1.00085456
96MP0004145_abnormal_muscle_electrophysio0.99803426
97MP0000858_altered_metastatic_potential0.99493217
98MP0001835_abnormal_antigen_presentation0.98442554
99MP0001119_abnormal_female_reproductive0.98281872
100MP0002876_abnormal_thyroid_physiology0.97089639
101MP0003186_abnormal_redox_activity0.93801566
102MP0002272_abnormal_nervous_system0.93321916
103MP0002132_abnormal_respiratory_system0.93301798
104MP0002160_abnormal_reproductive_system0.92604061
105MP0003137_abnormal_impulse_conducting0.91575600
106MP0003890_abnormal_embryonic-extraembry0.90709083
107MP0005384_cellular_phenotype0.89680245
108MP0000427_abnormal_hair_cycle0.88861156
109MP0001293_anophthalmia0.88654333
110MP0003941_abnormal_skin_development0.87437851
111MP0002429_abnormal_blood_cell0.87036681
112MP0005621_abnormal_cell_physiology0.86192831
113MP0009672_abnormal_birth_weight0.86022257
114MP0002090_abnormal_vision0.84521553
115MP0005451_abnormal_body_composition0.81645307
116MP0002735_abnormal_chemical_nociception0.81235729
117MP0003763_abnormal_thymus_physiology0.79969402
118MP0000015_abnormal_ear_pigmentation0.79319751
119MP0003806_abnormal_nucleotide_metabolis0.79016528
120MP0001324_abnormal_eye_pigmentation0.78462761
121MP0005195_abnormal_posterior_eye0.77962116
122MP0004742_abnormal_vestibular_system0.77579727
123MP0000537_abnormal_urethra_morphology0.76835016
124MP0000716_abnormal_immune_system0.76771882
125MP0005389_reproductive_system_phenotype0.76659247
126MP0005332_abnormal_amino_acid0.76355613
127MP0004215_abnormal_myocardial_fiber0.76087385
128MP0000647_abnormal_sebaceous_gland0.75908466
129MP0002557_abnormal_social/conspecific_i0.75290413
130MP0005636_abnormal_mineral_homeostasis0.73669563
131MP0003221_abnormal_cardiomyocyte_apopto0.72791541
132MP0003698_abnormal_male_reproductive0.72214791
133MP0000049_abnormal_middle_ear0.71850111
134MP0001800_abnormal_humoral_immune0.70244306
135MP0005266_abnormal_metabolism0.69828310
136MP0002452_abnormal_antigen_presenting0.69825484
137MP0004043_abnormal_pH_regulation0.68992063
138MP0001486_abnormal_startle_reflex0.68824758
139MP0006035_abnormal_mitochondrial_morpho0.66497050
140MP0002653_abnormal_ependyma_morphology0.66481808
141MP0001819_abnormal_immune_cell0.65692858
142MP0002420_abnormal_adaptive_immunity0.65369892
143MP0002752_abnormal_somatic_nervous0.65045901
144MP0003937_abnormal_limbs/digits/tail_de0.65023525
145MP0003699_abnormal_female_reproductive0.64832952
146MP0005395_other_phenotype0.64712354
147MP0000569_abnormal_digit_pigmentation0.64270687
148MP0004133_heterotaxia0.63875864
149MP0002161_abnormal_fertility/fecundity0.63653881
150MP0003448_altered_tumor_morphology0.62780489
151MP0010030_abnormal_orbit_morphology0.60908393
152MP0003119_abnormal_digestive_system0.60438142
153MP0002405_respiratory_system_inflammati0.60333818
154MP0005075_abnormal_melanosome_morpholog0.59259078
155MP0005174_abnormal_tail_pigmentation0.58139588
156MP0006036_abnormal_mitochondrial_physio0.57639964
157MP0002111_abnormal_tail_morphology0.57290062
158MP0001853_heart_inflammation0.56970096
159MP0005671_abnormal_response_to0.56223628
160MP0002723_abnormal_immune_serum0.55771372
161MP0003436_decreased_susceptibility_to0.53699753
162MP0003656_abnormal_erythrocyte_physiolo0.53116764
163MP0001286_abnormal_eye_development0.51703649
164MP0000627_abnormal_mammary_gland0.50062275

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.35622664
2Acute necrotizing encephalopathy (HP:0006965)5.23068233
3Chromsome breakage (HP:0040012)4.99710328
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.89048289
5Mitochondrial inheritance (HP:0001427)4.77769986
6Abnormal mitochondria in muscle tissue (HP:0008316)4.68801461
7Acute encephalopathy (HP:0006846)4.62424969
8Progressive macrocephaly (HP:0004481)4.47127493
9Increased CSF lactate (HP:0002490)4.41807709
10Reticulocytopenia (HP:0001896)4.35241425
11Breast hypoplasia (HP:0003187)4.31638631
12Hepatocellular necrosis (HP:0001404)4.28283916
13Hepatic necrosis (HP:0002605)4.01730285
14Patellar aplasia (HP:0006443)3.97589728
15Carpal bone hypoplasia (HP:0001498)3.91410630
16Abnormality of the preputium (HP:0100587)3.90734924
17Meckel diverticulum (HP:0002245)3.80250372
18Abnormality of chromosome stability (HP:0003220)3.75048253
19Aplasia/Hypoplasia of the patella (HP:0006498)3.73190464
20Increased hepatocellular lipid droplets (HP:0006565)3.71339777
21Impulsivity (HP:0100710)3.65904704
22Pancreatic cysts (HP:0001737)3.63734496
23Abnormality of the ileum (HP:0001549)3.63294129
24Aplasia/Hypoplasia of the uvula (HP:0010293)3.58199466
25Abnormality of the anterior horn cell (HP:0006802)3.54026980
26Degeneration of anterior horn cells (HP:0002398)3.54026980
27Abnormality of cells of the erythroid lineage (HP:0012130)3.53638479
28Lipid accumulation in hepatocytes (HP:0006561)3.51481999
29Oral leukoplakia (HP:0002745)3.45600610
30Abnormal number of erythroid precursors (HP:0012131)3.40184377
31Pancreatic fibrosis (HP:0100732)3.37303393
32Colon cancer (HP:0003003)3.31825522
33Cerebral edema (HP:0002181)3.29378528
34Molar tooth sign on MRI (HP:0002419)3.26994005
35Abnormality of midbrain morphology (HP:0002418)3.26994005
36True hermaphroditism (HP:0010459)3.19600116
37Rough bone trabeculation (HP:0100670)3.19520346
38Agnosia (HP:0010524)3.19146186
39Renal Fanconi syndrome (HP:0001994)3.17535093
403-Methylglutaconic aciduria (HP:0003535)3.00300949
41Duodenal stenosis (HP:0100867)2.97380624
42Small intestinal stenosis (HP:0012848)2.97380624
43Absent thumb (HP:0009777)2.95765967
44Absent radius (HP:0003974)2.95393128
45Selective tooth agenesis (HP:0001592)2.90579325
46Increased serum lactate (HP:0002151)2.90561911
47Myelodysplasia (HP:0002863)2.90285930
48Lactic acidosis (HP:0003128)2.83863221
49Cerebral hypomyelination (HP:0006808)2.82051155
50Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.81790567
51Congenital stationary night blindness (HP:0007642)2.81690350
52Optic disc pallor (HP:0000543)2.79655432
53Premature ovarian failure (HP:0008209)2.79613133
54Bone marrow hypocellularity (HP:0005528)2.77395940
55Respiratory failure (HP:0002878)2.75053658
56Absent forearm bone (HP:0003953)2.71965910
57Aplasia involving forearm bones (HP:0009822)2.71965910
58Horseshoe kidney (HP:0000085)2.70893454
59Nephronophthisis (HP:0000090)2.70490170
60Methylmalonic acidemia (HP:0002912)2.68428528
61Increased intramyocellular lipid droplets (HP:0012240)2.65183838
62Pallor (HP:0000980)2.64359426
63Ectopic kidney (HP:0000086)2.63944287
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.63888859
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62504461
66Abnormality of the labia minora (HP:0012880)2.62034640
67Duplicated collecting system (HP:0000081)2.58252324
68Microretrognathia (HP:0000308)2.56523072
69Type II lissencephaly (HP:0007260)2.55333862
70Aplastic anemia (HP:0001915)2.51915858
71Type I transferrin isoform profile (HP:0003642)2.49007119
72Premature graying of hair (HP:0002216)2.48474429
73Triphalangeal thumb (HP:0001199)2.48185706
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.48043852
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.48043852
76Sloping forehead (HP:0000340)2.47474772
77Tracheoesophageal fistula (HP:0002575)2.46707680
78Methylmalonic aciduria (HP:0012120)2.46168963
79Abnormal trabecular bone morphology (HP:0100671)2.44309114
80Macrocytic anemia (HP:0001972)2.44146654
81Secondary amenorrhea (HP:0000869)2.44035541
82Pendular nystagmus (HP:0012043)2.43394870
83Congenital, generalized hypertrichosis (HP:0004540)2.40352625
84Cleft eyelid (HP:0000625)2.39928281
85Abnormality of the duodenum (HP:0002246)2.39849449
86Cellular immunodeficiency (HP:0005374)2.37270480
87Medial flaring of the eyebrow (HP:0010747)2.35987599
88Leukodystrophy (HP:0002415)2.35316459
89Medulloblastoma (HP:0002885)2.34553259
90Clubbing of toes (HP:0100760)2.34229046
91Spinal muscular atrophy (HP:0007269)2.32364771
92Exercise intolerance (HP:0003546)2.27665656
93Ependymoma (HP:0002888)2.27213642
94Lethargy (HP:0001254)2.25561568
95Abnormality of the carotid arteries (HP:0005344)2.25484876
96Neoplasm of the pancreas (HP:0002894)2.25165067
97Sclerocornea (HP:0000647)2.24375785
9811 pairs of ribs (HP:0000878)2.20987295
99Abolished electroretinogram (ERG) (HP:0000550)2.20295513
100Rhabdomyosarcoma (HP:0002859)2.18639445
101Increased muscle lipid content (HP:0009058)2.16605914
102Multiple enchondromatosis (HP:0005701)2.16350914
103Abnormality of the renal medulla (HP:0100957)2.15680140
104CNS demyelination (HP:0007305)2.14156326
105Abnormal lung lobation (HP:0002101)2.13123057
106Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11998768
107Abnormal protein N-linked glycosylation (HP:0012347)2.11998768
108Abnormal protein glycosylation (HP:0012346)2.11998768
109Abnormal glycosylation (HP:0012345)2.11998768
110Personality changes (HP:0000751)2.11184615
111Short thumb (HP:0009778)2.09926083
112Abnormality of the renal collecting system (HP:0004742)2.09336434
113Abnormality of the renal cortex (HP:0011035)2.08344673
114Atrophy/Degeneration involving motor neurons (HP:0007373)2.06910987
115Abnormality of the pons (HP:0007361)2.06229614
116Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04221948
117Hypoplasia of the pons (HP:0012110)2.04164852
118Hypothermia (HP:0002045)2.03420064
119Ureteral duplication (HP:0000073)2.00833702
120Renal cortical cysts (HP:0000803)1.99629897
121Cystic liver disease (HP:0006706)1.99194094
122Anencephaly (HP:0002323)1.98736226
123Pancytopenia (HP:0001876)1.98325200
124Abnormality of DNA repair (HP:0003254)1.98261140
125Abnormality of pyrimidine metabolism (HP:0004353)1.97745109
126Abnormality of renal resorption (HP:0011038)1.97644109
127Aplasia/Hypoplasia of the earlobes (HP:0009906)1.97429557
128Basal cell carcinoma (HP:0002671)1.96978576
129Facial hemangioma (HP:0000329)1.96978079
130Breast aplasia (HP:0100783)1.96554806
131Supernumerary spleens (HP:0009799)1.95848902
132Absent epiphyses (HP:0010577)1.93442312
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.93442312
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92219522
135Abnormality of alanine metabolism (HP:0010916)1.92219522
136Hyperalaninemia (HP:0003348)1.92219522
137Exertional dyspnea (HP:0002875)1.91674224
138Cafe-au-lait spot (HP:0000957)1.91663175
139Abnormal rod and cone electroretinograms (HP:0008323)1.91264315
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.90950873
141Retinal dysplasia (HP:0007973)1.88408457
142Aplasia/Hypoplasia of the breasts (HP:0010311)1.87724437
143Abnormal spermatogenesis (HP:0008669)1.87440081
144Squamous cell carcinoma (HP:0002860)1.87247610
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86216722
146Generalized aminoaciduria (HP:0002909)1.86064703
147Abnormality of abdominal situs (HP:0011620)1.85638787
148Abdominal situs inversus (HP:0003363)1.85638787
149Attenuation of retinal blood vessels (HP:0007843)1.85277857
150Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85252765
151Trismus (HP:0000211)1.85128804
152Aplasia/Hypoplasia involving the musculature (HP:0001460)1.82542436
153X-linked dominant inheritance (HP:0001423)1.81977076
154Glycosuria (HP:0003076)1.81806438
155Abnormality of urine glucose concentration (HP:0011016)1.81806438
156Slender long bone (HP:0003100)1.81779595
157Respiratory difficulties (HP:0002880)1.81637820
158Male pseudohermaphroditism (HP:0000037)1.81412872
159Prominent nose (HP:0000448)1.80974138
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79991123
161Pulmonary fibrosis (HP:0002206)1.79561021
162Irregular epiphyses (HP:0010582)1.78595121
163Tongue fasciculations (HP:0001308)1.76412541
164Atresia of the external auditory canal (HP:0000413)1.75404410
165Leukopenia (HP:0001882)1.74616568
166Nephroblastoma (Wilms tumor) (HP:0002667)1.73808338
167Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73176132
168Dicarboxylic aciduria (HP:0003215)1.73176132
169Congenital primary aphakia (HP:0007707)1.72513270
170Gait imbalance (HP:0002141)1.72400546
171Capillary hemangiomas (HP:0005306)1.72247293
172Lymphoma (HP:0002665)1.72209963
173Cerebellar dysplasia (HP:0007033)1.71725879
174Furrowed tongue (HP:0000221)1.71331443
175Progressive inability to walk (HP:0002505)1.70725927
176Arteriovenous malformation (HP:0100026)1.70499094
177Aplasia/Hypoplasia of the sternum (HP:0006714)1.68367146
178Lissencephaly (HP:0001339)1.67322391
179Aplasia/Hypoplasia of the fovea (HP:0008060)1.66788632
180Hypoplasia of the fovea (HP:0007750)1.66788632
181Aplasia/hypoplasia of the uterus (HP:0008684)1.66016323
182Inability to walk (HP:0002540)1.65884769
183Thrombocytosis (HP:0001894)1.65591292
184Progressive microcephaly (HP:0000253)1.65298108
185Abnormality of the fovea (HP:0000493)1.62542109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.24185528
2VRK24.75346760
3WEE14.50450318
4CDC74.02352434
5EIF2AK13.31219238
6FRK3.01945170
7NEK22.83351157
8BRSK22.78076631
9MAP4K22.66248148
10NUAK12.62867442
11NME22.59293488
12SRPK12.54492184
13PLK42.50251091
14TTK2.49815170
15INSRR2.29904636
16ACVR1B2.29288500
17PLK12.23511785
18NEK12.19269746
19WNK32.13994285
20TESK22.09702100
21STK162.08219961
22MST42.03087472
23BMPR1B1.96683691
24BRSK11.91976887
25VRK11.83390885
26TLK11.80519883
27AURKB1.78946408
28EIF2AK31.77275764
29TRIM281.76763111
30ADRBK21.73298990
31PLK31.67026783
32CCNB11.64502381
33CDK71.60576952
34ATR1.60348748
35CHEK21.54180167
36DYRK31.50844918
37TSSK61.49717803
38GRK11.46159983
39BCKDK1.43087113
40RPS6KA41.40913830
41ZAK1.36614478
42AURKA1.36579677
43EIF2AK21.34453264
44TAF11.32739912
45MKNK11.29965131
46MAP3K121.26233625
47PNCK1.25439526
48CDK121.25045380
49TNIK1.23118724
50PIM21.22700238
51MAP3K81.19855238
52CHEK11.19189482
53MAPK131.15722841
54LATS21.14569032
55PINK11.14040602
56MUSK1.12913438
57CDK41.12585606
58BRAF1.11665660
59STK41.10158517
60RPS6KB21.07385955
61CSNK1G31.02140311
62OXSR11.01112349
63EPHA20.99555850
64MKNK20.98865902
65WNK40.97210581
66PDK20.96954292
67STK100.94938656
68STK38L0.93620818
69CSNK1G10.90618187
70PIM10.90110774
71DAPK10.89886474
72CSNK1G20.89530422
73TESK10.89493613
74ATM0.85465635
75CDK190.84470793
76KDR0.84193661
77MAPKAPK50.83859603
78ARAF0.83734416
79STK390.83673038
80MAP3K40.83513300
81TGFBR10.82384201
82TXK0.82284090
83CDK20.82270188
84CASK0.81954925
85STK30.79023422
86PLK20.78687556
87IRAK30.77425275
88PAK40.77093032
89PAK10.73726483
90ERBB30.73556350
91MAP2K70.70420287
92SCYL20.69353760
93CSNK2A10.67113011
94TAOK30.66981168
95DYRK20.66846686
96PRKCG0.66846343
97PASK0.65948139
98CDK80.65490440
99CDK10.63675488
100PRKCI0.61718366
101CSNK1A1L0.61694354
102MELK0.59868444
103CSNK2A20.57317906
104PAK30.56507171
105BRD40.54348089
106ABL20.54335422
107RAF10.52913634
108GRK50.52058361
109ADRBK10.52005370
110PHKG20.49020851
111PHKG10.49020851
112ALK0.48803220
113PBK0.47326455
114PRKCE0.45886890
115RPS6KA50.45003762
116TAOK20.43942737
117MAPKAPK30.40417908
118LATS10.40189027
119MARK30.40017688
120TEC0.39777606
121LIMK10.39074067
122CLK10.38046891
123MINK10.37592331
124NEK90.36272688
125IRAK40.36210293
126ILK0.36088369
127CSF1R0.35557675
128BCR0.35477060
129CSNK1A10.35066669
130CDK60.34498027
131IKBKB0.34291709
132TYK20.33758047
133AKT20.32753966
134GRK70.32312095
135DAPK20.31978039
136MAP3K50.31086781
137MAP3K110.30670352
138NME10.28681133
139STK240.27173494
140YES10.26339690
141LRRK20.26147801
142MAP4K10.25362062
143PRKDC0.24379737
144ZAP700.22712222
145LYN0.22485778
146CDK11A0.20155140
147EEF2K0.19784965
148MAPK140.17719955
149FLT30.16972782
150BLK0.16964191
151CSNK1E0.16680021

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.90067492
2Mismatch repair_Homo sapiens_hsa034304.09073761
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.79084887
4RNA polymerase_Homo sapiens_hsa030203.72627626
5Proteasome_Homo sapiens_hsa030503.61009081
6Base excision repair_Homo sapiens_hsa034103.33401925
7Ribosome_Homo sapiens_hsa030103.31736473
8Homologous recombination_Homo sapiens_hsa034403.30783344
9Spliceosome_Homo sapiens_hsa030403.17241614
10RNA transport_Homo sapiens_hsa030133.07661794
11Nucleotide excision repair_Homo sapiens_hsa034202.88086563
12Cell cycle_Homo sapiens_hsa041102.83342909
13Pyrimidine metabolism_Homo sapiens_hsa002402.68787325
14Fanconi anemia pathway_Homo sapiens_hsa034602.58373129
15One carbon pool by folate_Homo sapiens_hsa006702.28210899
16Alzheimers disease_Homo sapiens_hsa050102.26445808
17Non-homologous end-joining_Homo sapiens_hsa034502.26018398
18Basal transcription factors_Homo sapiens_hsa030222.15413625
19RNA degradation_Homo sapiens_hsa030181.84400548
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82661218
21p53 signaling pathway_Homo sapiens_hsa041151.73887274
22mRNA surveillance pathway_Homo sapiens_hsa030151.67476105
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63721453
24Cardiac muscle contraction_Homo sapiens_hsa042601.55743199
25Purine metabolism_Homo sapiens_hsa002301.45661857
26Butanoate metabolism_Homo sapiens_hsa006501.45141604
27Phototransduction_Homo sapiens_hsa047441.41944213
28Epstein-Barr virus infection_Homo sapiens_hsa051691.35497481
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32725668
30Vitamin B6 metabolism_Homo sapiens_hsa007501.31296308
31Propanoate metabolism_Homo sapiens_hsa006401.29509364
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23503225
33Fatty acid elongation_Homo sapiens_hsa000621.15565562
34Sulfur metabolism_Homo sapiens_hsa009201.11293734
35Oocyte meiosis_Homo sapiens_hsa041141.10273832
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06524116
37Collecting duct acid secretion_Homo sapiens_hsa049661.03827344
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03446291
39Nitrogen metabolism_Homo sapiens_hsa009101.03054319
40Pentose phosphate pathway_Homo sapiens_hsa000301.02893775
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02402132
42Tryptophan metabolism_Homo sapiens_hsa003801.00962806
43Systemic lupus erythematosus_Homo sapiens_hsa053220.98649066
44Herpes simplex infection_Homo sapiens_hsa051680.97637669
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95757836
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95623988
47Peroxisome_Homo sapiens_hsa041460.92704318
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92649944
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87577927
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.84308323
51Linoleic acid metabolism_Homo sapiens_hsa005910.81461536
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79902695
53Viral carcinogenesis_Homo sapiens_hsa052030.79328195
54Folate biosynthesis_Homo sapiens_hsa007900.78939514
55Antigen processing and presentation_Homo sapiens_hsa046120.76741863
56Pyruvate metabolism_Homo sapiens_hsa006200.76469969
57Huntingtons disease_Homo sapiens_hsa050160.75738104
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.71859591
59Regulation of autophagy_Homo sapiens_hsa041400.69826081
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.67582652
61Nicotine addiction_Homo sapiens_hsa050330.66491694
62HTLV-I infection_Homo sapiens_hsa051660.66161489
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66107723
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.64970634
65Caffeine metabolism_Homo sapiens_hsa002320.64664104
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61175140
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60729566
68Chemical carcinogenesis_Homo sapiens_hsa052040.58120958
69Selenocompound metabolism_Homo sapiens_hsa004500.57290172
70Biosynthesis of amino acids_Homo sapiens_hsa012300.56499156
71beta-Alanine metabolism_Homo sapiens_hsa004100.55919011
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52532141
73Apoptosis_Homo sapiens_hsa042100.51483766
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51276120
75Legionellosis_Homo sapiens_hsa051340.50598902
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49166941
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.48898700
78Shigellosis_Homo sapiens_hsa051310.48361280
79Olfactory transduction_Homo sapiens_hsa047400.45941427
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45055268
81Parkinsons disease_Homo sapiens_hsa050120.44276522
82MicroRNAs in cancer_Homo sapiens_hsa052060.43523053
83Ether lipid metabolism_Homo sapiens_hsa005650.43149911
84Glutathione metabolism_Homo sapiens_hsa004800.42000697
85Type I diabetes mellitus_Homo sapiens_hsa049400.41683890
86Steroid biosynthesis_Homo sapiens_hsa001000.40946095
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.40724522
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39180410
89Rheumatoid arthritis_Homo sapiens_hsa053230.38771425
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37313243
91Sulfur relay system_Homo sapiens_hsa041220.36943550
92Small cell lung cancer_Homo sapiens_hsa052220.36682065
93Measles_Homo sapiens_hsa051620.36674561
94Fatty acid degradation_Homo sapiens_hsa000710.36603246
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36156756
96Hepatitis B_Homo sapiens_hsa051610.34811910
97Influenza A_Homo sapiens_hsa051640.34685879
98Protein export_Homo sapiens_hsa030600.34685225
99Primary immunodeficiency_Homo sapiens_hsa053400.33925455
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33896355
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.33226990
102Taste transduction_Homo sapiens_hsa047420.32161582
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31349396
104Retinol metabolism_Homo sapiens_hsa008300.30786583
105Fructose and mannose metabolism_Homo sapiens_hsa000510.30585120
106Thyroid cancer_Homo sapiens_hsa052160.29555498
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29251933
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28730850
109TGF-beta signaling pathway_Homo sapiens_hsa043500.26321200
110Fatty acid metabolism_Homo sapiens_hsa012120.26144141
111Colorectal cancer_Homo sapiens_hsa052100.25587697
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.25325587
113Galactose metabolism_Homo sapiens_hsa000520.24929234
114Oxidative phosphorylation_Homo sapiens_hsa001900.24543891
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24341517
116Arachidonic acid metabolism_Homo sapiens_hsa005900.24062889
117Autoimmune thyroid disease_Homo sapiens_hsa053200.23989398
118Carbon metabolism_Homo sapiens_hsa012000.23630637
119HIF-1 signaling pathway_Homo sapiens_hsa040660.23012594
120Allograft rejection_Homo sapiens_hsa053300.22994618
121Viral myocarditis_Homo sapiens_hsa054160.22311924
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22003204
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21961915
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21209807
125Asthma_Homo sapiens_hsa053100.20947739
126Hippo signaling pathway_Homo sapiens_hsa043900.19695544
127Metabolic pathways_Homo sapiens_hsa011000.19146885
128Alcoholism_Homo sapiens_hsa050340.18989761
129N-Glycan biosynthesis_Homo sapiens_hsa005100.18925003
130Graft-versus-host disease_Homo sapiens_hsa053320.16905933
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16091689
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15601642
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15233595
134Leishmaniasis_Homo sapiens_hsa051400.14464093
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.13820367
136Chronic myeloid leukemia_Homo sapiens_hsa052200.13265924
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12748050
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11337172
139Acute myeloid leukemia_Homo sapiens_hsa052210.10292010
140FoxO signaling pathway_Homo sapiens_hsa040680.09458111
141Bladder cancer_Homo sapiens_hsa052190.09387659
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.09281900
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09259115
144mTOR signaling pathway_Homo sapiens_hsa041500.09049291
145Pathways in cancer_Homo sapiens_hsa052000.08610780
146B cell receptor signaling pathway_Homo sapiens_hsa046620.08541939

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