ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of light stimulus involved in sensory perception (GO:0050962)	5.47257059
2	detection of light stimulus involved in visual perception (GO:0050908)	5.47257059
3	rRNA catabolic process (GO:0016075)	5.10984003
4	L-fucose catabolic process (GO:0042355)	4.91985304
5	fucose catabolic process (GO:0019317)	4.91985304
6	L-fucose metabolic process (GO:0042354)	4.91985304
7	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	4.75457513
8	establishment of protein localization to Golgi (GO:0072600)	4.71483453
9	regulation of cilium movement (GO:0003352)	4.62680779
10	cAMP catabolic process (GO:0006198)	4.51826751
11	protein targeting to Golgi (GO:0000042)	4.41413386
12	cyclic nucleotide catabolic process (GO:0009214)	4.24207708
13	protein polyglutamylation (GO:0018095)	4.15275279
14	protein localization to Golgi apparatus (GO:0034067)	3.94900638
15	respiratory chain complex IV assembly (GO:0008535)	3.90170862
16	piRNA metabolic process (GO:0034587)	3.88488193
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.76595827
18	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.72725617
19	kynurenine metabolic process (GO:0070189)	3.60658305
20	epithelial cilium movement (GO:0003351)	3.54193901
21	cellular ketone body metabolic process (GO:0046950)	3.49115107
22	axoneme assembly (GO:0035082)	3.48958350
23	inositol phosphate catabolic process (GO:0071545)	3.42120172
24	DNA deamination (GO:0045006)	3.41696422
25	response to pheromone (GO:0019236)	3.41571874
26	ketone body metabolic process (GO:1902224)	3.37165616
27	regulation of glucokinase activity (GO:0033131)	3.36498538
28	regulation of hexokinase activity (GO:1903299)	3.36498538
29	indole-containing compound catabolic process (GO:0042436)	3.35347512
30	indolalkylamine catabolic process (GO:0046218)	3.35347512
31	tryptophan catabolic process (GO:0006569)	3.35347512
32	mannosylation (GO:0097502)	3.34466988
33	neural tube formation (GO:0001841)	3.21588667
34	cytochrome complex assembly (GO:0017004)	3.20858023
35	acrosome reaction (GO:0007340)	3.20613138
36	cellular response to ATP (GO:0071318)	3.20485999
37	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.17744603
38	inositol phosphate dephosphorylation (GO:0046855)	3.17744603
39	protein K6-linked ubiquitination (GO:0085020)	3.14736428
40	ncRNA catabolic process (GO:0034661)	3.13769671
41	tryptophan metabolic process (GO:0006568)	3.13234279
42	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.09035660
43	indolalkylamine metabolic process (GO:0006586)	3.08286656
44	regulation of meiosis I (GO:0060631)	3.07463048
45	protein prenylation (GO:0018342)	3.05503423
46	prenylation (GO:0097354)	3.05503423
47	behavioral response to nicotine (GO:0035095)	3.05353131
48	retinal cone cell development (GO:0046549)	3.01211776
49	cell wall macromolecule catabolic process (GO:0016998)	3.00703796
50	ubiquinone biosynthetic process (GO:0006744)	2.98739663
51	multicellular organism reproduction (GO:0032504)	2.95828690
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.93213555
53	regulation of microtubule-based movement (GO:0060632)	2.92912312
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.92834831
55	sperm motility (GO:0030317)	2.90575864
56	maturation of 5.8S rRNA (GO:0000460)	2.89619899
57	preassembly of GPI anchor in ER membrane (GO:0016254)	2.88578515
58	cilium morphogenesis (GO:0060271)	2.87877236
59	cell wall macromolecule metabolic process (GO:0044036)	2.86489882
60	seminiferous tubule development (GO:0072520)	2.86288413
61	regulation of protein kinase A signaling (GO:0010738)	2.84562604
62	intraciliary transport (GO:0042073)	2.82171734
63	adenosine metabolic process (GO:0046085)	2.81451129
64	polyol catabolic process (GO:0046174)	2.80206643
65	cilium movement (GO:0003341)	2.79085267
66	DNA methylation involved in gamete generation (GO:0043046)	2.76827085
67	cGMP metabolic process (GO:0046068)	2.75127887
68	ubiquinone metabolic process (GO:0006743)	2.74404267
69	photoreceptor cell maintenance (GO:0045494)	2.73928702
70	intra-Golgi vesicle-mediated transport (GO:0006891)	2.72903969
71	sphingosine metabolic process (GO:0006670)	2.70121181
72	protein localization to cilium (GO:0061512)	2.66929651
73	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.66795451
74	nonmotile primary cilium assembly (GO:0035058)	2.66082387
75	base-excision repair, AP site formation (GO:0006285)	2.62629393
76	protein complex biogenesis (GO:0070271)	2.62169826
77	cilium or flagellum-dependent cell motility (GO:0001539)	2.60333119
78	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.59942227
79	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.59194224
80	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.59194224
81	NADH dehydrogenase complex assembly (GO:0010257)	2.59194224
82	positive regulation of mitochondrial fission (GO:0090141)	2.58496589
83	sphingoid metabolic process (GO:0046519)	2.56934735
84	double-strand break repair via homologous recombination (GO:0000724)	2.55040737
85	centriole replication (GO:0007099)	2.54657195
86	recombinational repair (GO:0000725)	2.54511701
87	male meiosis I (GO:0007141)	2.54356225
88	DNA demethylation (GO:0080111)	2.53611528
89	DNA double-strand break processing (GO:0000729)	2.51903946
90	diol metabolic process (GO:0034311)	2.51670131
91	cilium organization (GO:0044782)	2.51411322
92	regulation of transmission of nerve impulse (GO:0051969)	2.50775833
93	protein-cofactor linkage (GO:0018065)	2.50463757
94	water-soluble vitamin biosynthetic process (GO:0042364)	2.47544671
95	brain morphogenesis (GO:0048854)	2.47328527
96	calcium ion import (GO:0070509)	2.45961522
97	regulation of collateral sprouting (GO:0048670)	2.45675654
98	GPI anchor metabolic process (GO:0006505)	2.45671289
99	RNA phosphodiester bond hydrolysis (GO:0090501)	2.45248114
100	keratinocyte development (GO:0003334)	2.44702152

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.60593954
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.32901199
3	VDR_22108803_ChIP-Seq_LS180_Human	3.28747758
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.88531434
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.70428104
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.68737027
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.54657153
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.46036113
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.35229772
10	FUS_26573619_Chip-Seq_HEK293_Human	2.20282575
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.16151157
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15051977
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.12461813
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.12431704
15	P300_19829295_ChIP-Seq_ESCs_Human	2.08354885
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.00534148
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.99828343
18	EWS_26573619_Chip-Seq_HEK293_Human	1.95033585
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.94675900
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.93975260
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87934184
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.84110306
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.83633121
24	CBP_20019798_ChIP-Seq_JUKART_Human	1.83633121
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.83568427
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.74963144
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.72109487
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.71405361
29	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.64936315
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.63447616
31	VDR_23849224_ChIP-Seq_CD4+_Human	1.56870753
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50558684
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49182087
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48590107
35	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.46689092
36	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.45417839
37	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.45234932
38	EZH2_22144423_ChIP-Seq_EOC_Human	1.43436441
39	STAT3_23295773_ChIP-Seq_U87_Human	1.43302308
40	AR_25329375_ChIP-Seq_VCAP_Human	1.43292370
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40950898
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40950898
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38421581
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38146010
45	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37819487
46	ELK1_19687146_ChIP-ChIP_HELA_Human	1.37557112
47	TCF4_23295773_ChIP-Seq_U87_Human	1.37017235
48	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.36440826
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35915189
50	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.33482372
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.30817428
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28444853
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28106419
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.27404960
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27198094
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.25919588
57	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25227553
58	P53_22387025_ChIP-Seq_ESCs_Mouse	1.24329993
59	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23982215
60	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.23134808
61	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.22076798
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21306447
63	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19798617
64	AR_21572438_ChIP-Seq_LNCaP_Human	1.19227560
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16939922
66	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.16807733
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16653064
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16207531
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15999203
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15169897
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14785336
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14785336
73	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14557490
74	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14557490
75	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13980925
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12524237
77	NCOR_22424771_ChIP-Seq_293T_Human	1.12339051
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.11645052
79	AR_20517297_ChIP-Seq_VCAP_Human	1.11446436
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11199154
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09616894
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09476046
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09161549
84	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08112629
85	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.07963496
86	MYC_18940864_ChIP-ChIP_HL60_Human	1.07927336
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07560825
88	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.07092393
89	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07021579
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.06468886
91	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.05752786
92	GATA3_26560356_Chip-Seq_TH2_Human	1.04304277
93	P300_18555785_Chip-Seq_ESCs_Mouse	1.03888007
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02480433
95	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.02162942
96	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01754375
97	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01596312
98	CDX2_22108803_ChIP-Seq_LS180_Human	0.98794849
99	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.98742075
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98660558

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.56579072
2	MP0002102_abnormal_ear_morphology	3.17836227
3	MP0005551_abnormal_eye_electrophysiolog	2.90200477
4	MP0003195_calcinosis	2.77830736
5	MP0008058_abnormal_DNA_repair	2.44508524
6	MP0004142_abnormal_muscle_tone	2.41119668
7	MP0002876_abnormal_thyroid_physiology	2.26422412
8	MP0008875_abnormal_xenobiotic_pharmacok	2.22153979
9	MP0005253_abnormal_eye_physiology	2.16215233
10	MP0003787_abnormal_imprinting	2.16148800
11	MP0003880_abnormal_central_pattern	2.08318413
12	MP0006292_abnormal_olfactory_placode	2.07527192
13	MP0001529_abnormal_vocalization	2.00553157
14	MP0001968_abnormal_touch/_nociception	2.00088136
15	MP0009046_muscle_twitch	1.96402613
16	MP0006072_abnormal_retinal_apoptosis	1.91786420
17	MP0002837_dystrophic_cardiac_calcinosis	1.90607754
18	MP0003718_maternal_effect	1.88862887
19	MP0005645_abnormal_hypothalamus_physiol	1.85049348
20	MP0008872_abnormal_physiological_respon	1.84773096
21	MP0001501_abnormal_sleep_pattern	1.76754125
22	MP0003646_muscle_fatigue	1.67564820
23	MP0005410_abnormal_fertilization	1.66062133
24	MP0000372_irregular_coat_pigmentation	1.64611025
25	MP0004147_increased_porphyrin_level	1.64536499
26	MP0006276_abnormal_autonomic_nervous	1.63116950
27	MP0002736_abnormal_nociception_after	1.59633715
28	MP0001984_abnormal_olfaction	1.58060601
29	MP0001986_abnormal_taste_sensitivity	1.55528937
30	MP0004043_abnormal_pH_regulation	1.54927413
31	MP0002638_abnormal_pupillary_reflex	1.51960509
32	MP0001764_abnormal_homeostasis	1.46613804
33	MP0001486_abnormal_startle_reflex	1.44132349
34	MP0006082_CNS_inflammation	1.41610516
35	MP0002272_abnormal_nervous_system	1.37774050
36	MP0005646_abnormal_pituitary_gland	1.36814820
37	MP0002572_abnormal_emotion/affect_behav	1.36638250
38	MP0004924_abnormal_behavior	1.30793643
39	MP0005386_behavior/neurological_phenoty	1.30793643
40	MP0005360_urolithiasis	1.28253754
41	MP0009745_abnormal_behavioral_response	1.26467643
42	MP0004885_abnormal_endolymph	1.25243177
43	MP0000569_abnormal_digit_pigmentation	1.22143297
44	MP0005075_abnormal_melanosome_morpholog	1.22113226
45	MP0000631_abnormal_neuroendocrine_gland	1.20588691
46	MP0006036_abnormal_mitochondrial_physio	1.15584237
47	MP0000427_abnormal_hair_cycle	1.15232462
48	MP0004133_heterotaxia	1.14473930
49	MP0002138_abnormal_hepatobiliary_system	1.14143462
50	MP0004145_abnormal_muscle_electrophysio	1.13572456
51	MP0001970_abnormal_pain_threshold	1.13002157
52	MP0001929_abnormal_gametogenesis	1.11448401
53	MP0002733_abnormal_thermal_nociception	1.11289246
54	MP0002557_abnormal_social/conspecific_i	1.11251956
55	MP0002734_abnormal_mechanical_nocicepti	1.10697395
56	MP0003698_abnormal_male_reproductive	1.09602423
57	MP0008775_abnormal_heart_ventricle	1.08844626
58	MP0004484_altered_response_of	1.07541592
59	MP0005195_abnormal_posterior_eye	1.06773209
60	MP0009764_decreased_sensitivity_to	1.06651792
61	MP0003950_abnormal_plasma_membrane	1.04399547
62	MP0004215_abnormal_myocardial_fiber	1.04361142
63	MP0002090_abnormal_vision	1.03408315
64	MP0008057_abnormal_DNA_replication	1.00978986
65	MP0001835_abnormal_antigen_presentation	1.00592026
66	MP0005636_abnormal_mineral_homeostasis	0.99792391
67	MP0006035_abnormal_mitochondrial_morpho	0.97969662
68	MP0002229_neurodegeneration	0.97899604
69	MP0002064_seizures	0.96883215
70	MP0002184_abnormal_innervation	0.96419728
71	MP0001905_abnormal_dopamine_level	0.95991776
72	MP0000647_abnormal_sebaceous_gland	0.95261211
73	MP0002735_abnormal_chemical_nociception	0.95206615
74	MP0002928_abnormal_bile_duct	0.93984901
75	MP0008789_abnormal_olfactory_epithelium	0.93427924
76	MP0005084_abnormal_gallbladder_morpholo	0.93219213
77	MP0003121_genomic_imprinting	0.92454354
78	MP0002751_abnormal_autonomic_nervous	0.89775534
79	MP0005379_endocrine/exocrine_gland_phen	0.88311899
80	MP0005389_reproductive_system_phenotype	0.88166860
81	MP0002067_abnormal_sensory_capabilities	0.87480050
82	MP0001485_abnormal_pinna_reflex	0.86729057
83	MP0003878_abnormal_ear_physiology	0.85868708
84	MP0005377_hearing/vestibular/ear_phenot	0.85868708
85	MP0003186_abnormal_redox_activity	0.85456976
86	MP0001765_abnormal_ion_homeostasis	0.85212311
87	MP0005332_abnormal_amino_acid	0.84342813
88	MP0010094_abnormal_chromosome_stability	0.84255482
89	MP0002752_abnormal_somatic_nervous	0.83886407
90	MP0009697_abnormal_copulation	0.82556212
91	MP0002063_abnormal_learning/memory/cond	0.81908821
92	MP0003252_abnormal_bile_duct	0.81370998
93	MP0005408_hypopigmentation	0.80997885
94	MP0003786_premature_aging	0.78709041
95	MP0002938_white_spotting	0.78060854
96	MP0001963_abnormal_hearing_physiology	0.77962439
97	MP0005391_vision/eye_phenotype	0.77621337
98	MP0002210_abnormal_sex_determination	0.77507046
99	MP0002234_abnormal_pharynx_morphology	0.76813908
100	MP0005671_abnormal_response_to	0.76342837

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	6.01132746
2	Abnormal rod and cone electroretinograms (HP:0008323)	5.07117260
3	Hypoplasia of the fovea (HP:0007750)	4.60757133
4	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.60757133
5	Severe visual impairment (HP:0001141)	4.57512663
6	Abnormality of macular pigmentation (HP:0008002)	4.01734947
7	Abnormality of the fovea (HP:0000493)	3.79204388
8	Central scotoma (HP:0000603)	3.62505648
9	Abnormality of midbrain morphology (HP:0002418)	3.61906294
10	Molar tooth sign on MRI (HP:0002419)	3.61906294
11	Renal cortical cysts (HP:0000803)	3.56277328
12	Abnormality of the renal cortex (HP:0011035)	3.41910953
13	Pancreatic cysts (HP:0001737)	3.33522147
14	Nephronophthisis (HP:0000090)	3.03914823
15	Chronic hepatic failure (HP:0100626)	2.98481459
16	Attenuation of retinal blood vessels (HP:0007843)	2.96702922
17	Aplasia/Hypoplasia of the macula (HP:0008059)	2.95634749
18	Pancreatic fibrosis (HP:0100732)	2.93632546
19	True hermaphroditism (HP:0010459)	2.86168241
20	Decreased central vision (HP:0007663)	2.85226965
21	Medial flaring of the eyebrow (HP:0010747)	2.78277357
22	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.77751391
23	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.76003422
24	Abnormality of the renal medulla (HP:0100957)	2.75985256
25	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.74030712
26	Albinism (HP:0001022)	2.67235389
27	Type II lissencephaly (HP:0007260)	2.64459719
28	Tubulointerstitial nephritis (HP:0001970)	2.63361187
29	Abolished electroretinogram (ERG) (HP:0000550)	2.52713490
30	Hepatic necrosis (HP:0002605)	2.46383079
31	Constricted visual fields (HP:0001133)	2.45706778
32	Scotoma (HP:0000575)	2.39481608
33	Stomatitis (HP:0010280)	2.37470840
34	Hypochromic microcytic anemia (HP:0004840)	2.31442492
35	Hypoproteinemia (HP:0003075)	2.31033426
36	Inability to walk (HP:0002540)	2.27090755
37	Hepatocellular necrosis (HP:0001404)	2.26189108
38	Increased CSF lactate (HP:0002490)	2.26161436
39	Tubular atrophy (HP:0000092)	2.25715456
40	Optic nerve hypoplasia (HP:0000609)	2.25585896
41	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.25454969
42	Acute necrotizing encephalopathy (HP:0006965)	2.23149693
43	Congenital primary aphakia (HP:0007707)	2.21939712
44	Mitochondrial inheritance (HP:0001427)	2.21642860
45	Gait imbalance (HP:0002141)	2.21288950
46	Stomach cancer (HP:0012126)	2.21169841
47	Abnormality of DNA repair (HP:0003254)	2.17087722
48	Progressive macrocephaly (HP:0004481)	2.16462192
49	Colon cancer (HP:0003003)	2.15524118
50	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.14980793
51	Progressive inability to walk (HP:0002505)	2.13259377
52	3-Methylglutaconic aciduria (HP:0003535)	2.10116081
53	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.08878992
54	Abnormal drinking behavior (HP:0030082)	2.08421504
55	Polydipsia (HP:0001959)	2.08421504
56	Increased corneal curvature (HP:0100692)	2.07260508
57	Keratoconus (HP:0000563)	2.07260508
58	Cerebellar dysplasia (HP:0007033)	2.03680338
59	Type I transferrin isoform profile (HP:0003642)	2.01694151
60	Cystic liver disease (HP:0006706)	2.00909197
61	Bile duct proliferation (HP:0001408)	2.00568020
62	Abnormal biliary tract physiology (HP:0012439)	2.00568020
63	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.99516318
64	Abnormality of alanine metabolism (HP:0010916)	1.99516318
65	Hyperalaninemia (HP:0003348)	1.99516318
66	Methylmalonic acidemia (HP:0002912)	1.99247003
67	Nephrogenic diabetes insipidus (HP:0009806)	1.99045602
68	Fair hair (HP:0002286)	1.98799610
69	Optic disc pallor (HP:0000543)	1.98459083
70	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.96167775
71	Abnormal protein N-linked glycosylation (HP:0012347)	1.96167775
72	Abnormal protein glycosylation (HP:0012346)	1.96167775
73	Abnormal glycosylation (HP:0012345)	1.96167775
74	Ketosis (HP:0001946)	1.95995556
75	Abnormal mitochondria in muscle tissue (HP:0008316)	1.95867100
76	Hyperventilation (HP:0002883)	1.91826561
77	Bony spicule pigmentary retinopathy (HP:0007737)	1.89096185
78	Acute encephalopathy (HP:0006846)	1.88499553
79	Protruding tongue (HP:0010808)	1.87783465
80	Absent speech (HP:0001344)	1.86477539
81	Lissencephaly (HP:0001339)	1.84325378
82	Increased serum lactate (HP:0002151)	1.83346074
83	Intestinal atresia (HP:0011100)	1.80701656
84	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.79420995
85	Hyperglycinuria (HP:0003108)	1.79096456
86	Broad-based gait (HP:0002136)	1.78031148
87	Astigmatism (HP:0000483)	1.76465663
88	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.75971411
89	Absent/shortened dynein arms (HP:0200106)	1.75971411
90	Congenital hepatic fibrosis (HP:0002612)	1.75110215
91	Lipid accumulation in hepatocytes (HP:0006561)	1.74760071
92	Poor head control (HP:0002421)	1.73621701
93	Short tibia (HP:0005736)	1.71320943
94	Pendular nystagmus (HP:0012043)	1.69880745
95	Polyuria (HP:0000103)	1.69038196
96	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.68668226
97	Tubulointerstitial abnormality (HP:0001969)	1.67837385
98	Postaxial foot polydactyly (HP:0001830)	1.67786513
99	CNS demyelination (HP:0007305)	1.67353300
100	Pachygyria (HP:0001302)	1.66767694

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.34962599
2	MAP4K2	3.23820413
3	ADRBK2	2.78937920
4	BRD4	2.65530275
5	WNK3	2.47758007
6	TAOK3	2.30048780
7	WNK4	2.21583720
8	BMPR1B	2.18868820
9	TRIM28	2.13538309
10	BCR	2.13312460
11	CASK	2.12090151
12	PINK1	2.10633947
13	NUAK1	2.06783092
14	TNIK	2.03656157
15	MAP3K4	2.02920530
16	CSNK1G3	1.93510242
17	ZAK	1.92301286
18	CSNK1A1L	1.86757193
19	GRK1	1.84976955
20	CDK19	1.70689726
21	OXSR1	1.66885509
22	ERBB3	1.61920650
23	CSNK1G1	1.60792532
24	MST4	1.55666024
25	CSNK1G2	1.49803224
26	STK38L	1.43338491
27	TLK1	1.42315983
28	BMPR2	1.36869771
29	PNCK	1.29394350
30	EIF2AK3	1.28855605
31	VRK1	1.28583940
32	DAPK2	1.26163558
33	EPHA4	1.25901512
34	PAK3	1.21864169
35	BCKDK	1.10855516
36	MAPK13	1.08881334
37	BLK	1.05881322
38	INSRR	1.02915228
39	TXK	0.98480974
40	STK39	0.93031381
41	TRPM7	0.92662136
42	TEC	0.92188143
43	PLK4	0.91292779
44	MAP2K7	0.90203361
45	MARK1	0.86356388
46	SRPK1	0.84908250
47	PTK2B	0.84899302
48	VRK2	0.83619601
49	PRKCE	0.83386272
50	PLK2	0.82946742
51	IKBKB	0.79117370
52	ACVR1B	0.78354910
53	DAPK1	0.78157040
54	MKNK2	0.77647825
55	DYRK2	0.75298845
56	ATR	0.72064218
57	RPS6KA4	0.71421903
58	PLK3	0.64695792
59	PRKCG	0.61114457
60	KIT	0.60913218
61	CSF1R	0.59167450
62	CDK3	0.57721139
63	CSNK1A1	0.57210551
64	MARK3	0.56853276
65	MAPKAPK3	0.56476297
66	GRK6	0.55658270
67	NTRK3	0.54635518
68	ADRBK1	0.54355795
69	ITK	0.53840565
70	CAMKK2	0.53143320
71	CAMK2A	0.49525767
72	TIE1	0.46387538
73	PRKACA	0.46054379
74	MKNK1	0.45798811
75	RPS6KA5	0.43625914
76	CSNK1D	0.43215673
77	PIK3CG	0.43157734
78	LYN	0.43014686
79	PHKG2	0.41905333
80	PHKG1	0.41905333
81	ABL1	0.41855495
82	CAMK1	0.41243291
83	CHUK	0.41177093
84	TGFBR1	0.39568476
85	PLK1	0.37389538
86	MUSK	0.34777186
87	PRKG1	0.34191304
88	FLT3	0.34142074
89	MINK1	0.33461334
90	PRKCA	0.33032450
91	MET	0.32924836
92	FER	0.32175955
93	SYK	0.31977396
94	ATM	0.31897402
95	FES	0.31042857
96	IGF1R	0.30164796
97	NME1	0.29926188
98	GRK5	0.29490599
99	PDK2	0.29473061
100	PRKAA1	0.29002511

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.17420706
2	Phototransduction_Homo sapiens_hsa04744	2.91585733
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.51902244
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.43085681
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.42052955
6	Protein export_Homo sapiens_hsa03060	2.31991545
7	Allograft rejection_Homo sapiens_hsa05330	2.20620913
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.19204810
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.16135881
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.14213762
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.06395593
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.03756403
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.98881972
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.93244080
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.92972518
16	Butanoate metabolism_Homo sapiens_hsa00650	1.92138210
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.91398616
18	RNA degradation_Homo sapiens_hsa03018	1.83750132
19	Propanoate metabolism_Homo sapiens_hsa00640	1.78358403
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.77481012
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.72379752
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.65862801
23	Proteasome_Homo sapiens_hsa03050	1.62107878
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.49814030
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.48093463
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.44892431
27	Morphine addiction_Homo sapiens_hsa05032	1.41276055
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.40333894
29	Homologous recombination_Homo sapiens_hsa03440	1.40188834
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.39149503
31	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.37663220
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.37243419
33	beta-Alanine metabolism_Homo sapiens_hsa00410	1.32134153
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.28677380
35	Regulation of autophagy_Homo sapiens_hsa04140	1.25821385
36	Nicotine addiction_Homo sapiens_hsa05033	1.21098198
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.18930087
38	GABAergic synapse_Homo sapiens_hsa04727	1.14988422
39	Basal transcription factors_Homo sapiens_hsa03022	1.11311807
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10749497
41	Peroxisome_Homo sapiens_hsa04146	1.09472788
42	Olfactory transduction_Homo sapiens_hsa04740	1.09438922
43	Taste transduction_Homo sapiens_hsa04742	1.06670507
44	RNA polymerase_Homo sapiens_hsa03020	1.05792846
45	Parkinsons disease_Homo sapiens_hsa05012	1.03992359
46	RNA transport_Homo sapiens_hsa03013	1.02869853
47	One carbon pool by folate_Homo sapiens_hsa00670	1.01215580
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99819262
49	Rheumatoid arthritis_Homo sapiens_hsa05323	0.94793973
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.94344084
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.92661066
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92244568
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89539183
54	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.84044574
55	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.83989331
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81309728
57	Serotonergic synapse_Homo sapiens_hsa04726	0.80992281
58	Alzheimers disease_Homo sapiens_hsa05010	0.77770535
59	Caffeine metabolism_Homo sapiens_hsa00232	0.77207020
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.76522341
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.76466248
62	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.74729774
63	Purine metabolism_Homo sapiens_hsa00230	0.73652447
64	Sphingolipid metabolism_Homo sapiens_hsa00600	0.72784824
65	Huntingtons disease_Homo sapiens_hsa05016	0.71607203
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71101847
67	Fatty acid elongation_Homo sapiens_hsa00062	0.70024200
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.68877129
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.67594345
70	Circadian entrainment_Homo sapiens_hsa04713	0.66407717
71	Insulin secretion_Homo sapiens_hsa04911	0.64817817
72	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.64336063
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59614916
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58840206
75	Antigen processing and presentation_Homo sapiens_hsa04612	0.58362310
76	Metabolic pathways_Homo sapiens_hsa01100	0.57879302
77	Fatty acid metabolism_Homo sapiens_hsa01212	0.55234462
78	Lysine degradation_Homo sapiens_hsa00310	0.53646460
79	Viral myocarditis_Homo sapiens_hsa05416	0.50850799
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50787772
81	Nucleotide excision repair_Homo sapiens_hsa03420	0.50123656
82	Histidine metabolism_Homo sapiens_hsa00340	0.48660095
83	Renin secretion_Homo sapiens_hsa04924	0.48598848
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.47398598
85	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.46856231
86	Salivary secretion_Homo sapiens_hsa04970	0.46843237
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43977857
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.41465454
89	ABC transporters_Homo sapiens_hsa02010	0.41459047
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.40444702
91	Fatty acid degradation_Homo sapiens_hsa00071	0.40411895
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39266035
93	Primary immunodeficiency_Homo sapiens_hsa05340	0.38694078
94	Retinol metabolism_Homo sapiens_hsa00830	0.38044223
95	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.37313594
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.36674490
97	Base excision repair_Homo sapiens_hsa03410	0.36486209
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.34645428
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34338597
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33397385

ANAPC1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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