ANAPC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)4.44537877
2COPI coating of Golgi vesicle (GO:0048205)4.03724706
3Golgi transport vesicle coating (GO:0048200)4.03724706
4regulation of early endosome to late endosome transport (GO:2000641)4.00432897
5negative regulation of cell size (GO:0045792)3.89800400
6peptidyl-arginine omega-N-methylation (GO:0035247)3.83862451
7Arp2/3 complex-mediated actin nucleation (GO:0034314)3.57913925
8response to muramyl dipeptide (GO:0032495)3.53843621
9negative regulation of cell killing (GO:0031342)3.52571178
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52571178
11maternal placenta development (GO:0001893)3.44006119
12barbed-end actin filament capping (GO:0051016)3.43802907
13positive regulation of gamma-delta T cell activation (GO:0046645)3.43758134
14positive regulation of histone deacetylation (GO:0031065)3.37708196
15thymic T cell selection (GO:0045061)3.36850361
16negative regulation of microtubule polymerization (GO:0031115)3.35882935
17positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.35136780
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30022354
19protein localization to endosome (GO:0036010)3.28116168
20pentose-phosphate shunt (GO:0006098)3.27687788
21epithelial cell differentiation involved in prostate gland development (GO:0060742)3.27383450
22positive thymic T cell selection (GO:0045059)3.27288671
23DNA unwinding involved in DNA replication (GO:0006268)3.26683617
24protein retention in ER lumen (GO:0006621)3.26276875
25morphogenesis of an endothelium (GO:0003159)3.24377255
26endothelial tube morphogenesis (GO:0061154)3.24377255
27positive regulation of protein deacetylation (GO:0090312)3.23829933
28peptidyl-arginine N-methylation (GO:0035246)3.22868490
29peptidyl-arginine methylation (GO:0018216)3.22868490
30NIK/NF-kappaB signaling (GO:0038061)3.21028535
31ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.19757684
32apoptotic cell clearance (GO:0043277)3.16055088
33protein heterotrimerization (GO:0070208)3.15848775
34glucocorticoid receptor signaling pathway (GO:0042921)3.11576034
35regulation of SMAD protein import into nucleus (GO:0060390)3.11475916
36cortical actin cytoskeleton organization (GO:0030866)3.06510669
37regulation of translational termination (GO:0006449)3.06036557
38response to peptidoglycan (GO:0032494)3.05180294
39adherens junction assembly (GO:0034333)3.04873997
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.02702797
41response to laminar fluid shear stress (GO:0034616)3.02198379
42negative regulation of erythrocyte differentiation (GO:0045647)3.00049550
43cell-substrate adherens junction assembly (GO:0007045)2.99271805
44focal adhesion assembly (GO:0048041)2.99271805
45regulation of protein heterodimerization activity (GO:0043497)2.98757827
46positive regulation of SMAD protein import into nucleus (GO:0060391)2.98267675
47activation of Rac GTPase activity (GO:0032863)2.97366920
48positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.97288394
49epithelial cell-cell adhesion (GO:0090136)2.96620628
503-UTR-mediated mRNA stabilization (GO:0070935)2.96381508
51polarized epithelial cell differentiation (GO:0030859)2.95029861
52dosage compensation (GO:0007549)2.92542757
53regulation of histone H3-K27 methylation (GO:0061085)2.90805145
54germinal center formation (GO:0002467)2.90194029
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88717882
56positive regulation by organism of defense response of other organism involved in symbiotic interact2.88717882
57modulation by symbiont of host immune response (GO:0052553)2.88717882
58positive regulation by symbiont of host defense response (GO:0052509)2.88717882
59modulation by symbiont of host defense response (GO:0052031)2.88717882
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88717882
61heterochromatin organization (GO:0070828)2.86922357
62NADPH regeneration (GO:0006740)2.86878718
63endodermal cell differentiation (GO:0035987)2.86201386
64regulation of type I interferon-mediated signaling pathway (GO:0060338)2.85636814
65basement membrane organization (GO:0071711)2.85249839
66positive regulation of Cdc42 GTPase activity (GO:0043089)2.85206850
67planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83988738
68negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.83366984
69cytoskeletal anchoring at plasma membrane (GO:0007016)2.83239312
70embryonic process involved in female pregnancy (GO:0060136)2.81478813
71negative regulation of fatty acid transport (GO:2000192)2.81051613
72regulation of ARF protein signal transduction (GO:0032012)2.80519773
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80054935
74regulation of ARF GTPase activity (GO:0032312)2.79968506
75modulation by symbiont of host cellular process (GO:0044068)2.78971003
76regulation of gamma-delta T cell activation (GO:0046643)2.78672714
77detection of bacterium (GO:0016045)2.78214152
78platelet aggregation (GO:0070527)2.78026722
79T cell selection (GO:0045058)2.77774181
80stress fiber assembly (GO:0043149)2.77096663
81activation of MAPKKK activity (GO:0000185)2.74044895
82detection of other organism (GO:0098543)2.72207957
83positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.71917715
84regulation of glucose import in response to insulin stimulus (GO:2001273)2.71851651
85regulation of hippo signaling (GO:0035330)2.71082598
86macrophage activation involved in immune response (GO:0002281)2.71073183
87activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.70573581
88positive regulation of nuclease activity (GO:0032075)2.70255719
89histone arginine methylation (GO:0034969)2.69077203
90negative regulation of RNA splicing (GO:0033119)2.68716526
91regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.68227059
92chondrocyte proliferation (GO:0035988)2.68167376
93peptidyl-lysine dimethylation (GO:0018027)2.66146055
94regulation of NFAT protein import into nucleus (GO:0051532)2.65968690
95modulation by virus of host process (GO:0019054)2.65589260
96antigen processing and presentation via MHC class Ib (GO:0002475)2.65272251
97T cell apoptotic process (GO:0070231)2.63641306
98activation of JUN kinase activity (GO:0007257)2.63616079
99regulation of gamma-delta T cell differentiation (GO:0045586)2.63009258
100skin morphogenesis (GO:0043589)2.58616598
101leukocyte aggregation (GO:0070486)2.58573043
102hippo signaling (GO:0035329)2.58568934
103semaphorin-plexin signaling pathway (GO:0071526)2.57263720
104regulation of extracellular matrix disassembly (GO:0010715)2.57072858
105regulation of translational fidelity (GO:0006450)2.56013476
106corticosteroid receptor signaling pathway (GO:0031958)2.55818488
107antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.55694566
108antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.55694566
109regulation of leukocyte degranulation (GO:0043300)2.55620766
110regulation of T-helper 2 cell differentiation (GO:0045628)2.54698365
111retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54372858
112RNA stabilization (GO:0043489)2.54324754
113mRNA stabilization (GO:0048255)2.54324754
114pre-miRNA processing (GO:0031054)2.54069029
115positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.51526947
116negative thymic T cell selection (GO:0045060)2.51070011
117folic acid-containing compound biosynthetic process (GO:0009396)2.50891746
118regulation of defense response to virus by virus (GO:0050690)2.50662818
119regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.50126365
120negative regulation of toll-like receptor signaling pathway (GO:0034122)2.49774189
121labyrinthine layer blood vessel development (GO:0060716)2.49269873
122signal complex assembly (GO:0007172)2.47870044
123apoptotic process involved in morphogenesis (GO:0060561)2.47662243
124wound healing, spreading of epidermal cells (GO:0035313)2.46781470
125negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.46752445
126negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.46678126
127positive regulation of protein dephosphorylation (GO:0035307)2.46116204
128formation of translation preinitiation complex (GO:0001731)2.45896711
129histone H3-K36 demethylation (GO:0070544)2.45568998
130nucleosome disassembly (GO:0006337)2.45096592
131protein-DNA complex disassembly (GO:0032986)2.45096592
132negative regulation of myotube differentiation (GO:0010832)2.44778409
133protein localization to kinetochore (GO:0034501)2.43683135
134cortical cytoskeleton organization (GO:0030865)2.43045258
135regulation of chromatin binding (GO:0035561)2.41813848
136lipopolysaccharide-mediated signaling pathway (GO:0031663)2.41658073
137regulation of mammary gland epithelial cell proliferation (GO:0033599)2.41283452
138regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.41206718
139positive regulation of blood vessel endothelial cell migration (GO:0043536)2.40867002
140outer ear morphogenesis (GO:0042473)2.40748006
141positive regulation of lamellipodium assembly (GO:0010592)2.40147884
142regulation of nuclease activity (GO:0032069)2.39944525
143negative regulation of viral release from host cell (GO:1902187)2.39306062
144cellular response to virus (GO:0098586)2.38776163
145heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.38432932
146regulation of necroptotic process (GO:0060544)2.38098661
147pinocytosis (GO:0006907)2.37571676
148cell-substrate junction assembly (GO:0007044)2.35584848
149positive T cell selection (GO:0043368)2.35578733
150B cell receptor signaling pathway (GO:0050853)2.35217554
151cell adhesion mediated by integrin (GO:0033627)2.34900840
152neuron projection extension involved in neuron projection guidance (GO:1902284)2.34540569
153axon extension involved in axon guidance (GO:0048846)2.34540569
154regulation of interferon-beta biosynthetic process (GO:0045357)2.34048550
155lymphocyte apoptotic process (GO:0070227)2.33928491
156negative regulation of catenin import into nucleus (GO:0035414)2.33603470
157negative regulation of mRNA processing (GO:0050686)2.33356826
158regulation of tight junction assembly (GO:2000810)2.32376698
159fibroblast migration (GO:0010761)2.32020884
160histone H4 deacetylation (GO:0070933)2.30829582
161tolerance induction (GO:0002507)2.30825466
162apoptotic process involved in development (GO:1902742)2.30656928
163positive regulation of lamellipodium organization (GO:1902745)2.29911152
164low-density lipoprotein particle clearance (GO:0034383)2.29758496
165spliceosomal tri-snRNP complex assembly (GO:0000244)2.29437497
166positive regulation of Rap GTPase activity (GO:0032854)2.29243016
167regulation of myeloid leukocyte mediated immunity (GO:0002886)2.27793779
168actin nucleation (GO:0045010)2.27651780
169antigen processing and presentation of endogenous antigen (GO:0019883)2.27089168
170intracellular estrogen receptor signaling pathway (GO:0030520)2.26742881
171detection of external biotic stimulus (GO:0098581)2.26698106
172cellular response to epidermal growth factor stimulus (GO:0071364)2.26413968
173negative T cell selection (GO:0043383)2.26314952
174positive regulation of epithelial to mesenchymal transition (GO:0010718)2.26069448
175negative regulation of necroptotic process (GO:0060546)2.23221486
176positive regulation of receptor recycling (GO:0001921)2.22629094

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.41396486
2MYC_22102868_ChIP-Seq_BL_Human3.02020813
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.01810019
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97842176
5E2F7_22180533_ChIP-Seq_HELA_Human2.89754228
6VDR_21846776_ChIP-Seq_THP-1_Human2.49899880
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.44812614
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.43700430
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31960101
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22179032
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.18173671
12KDM2B_26808549_Chip-Seq_DND41_Human2.07786614
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.07071573
14* LXR_22292898_ChIP-Seq_THP-1_Human2.06223940
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.05146156
16CLOCK_20551151_ChIP-Seq_293T_Human2.03846174
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90363650
18TCF7_22412390_ChIP-Seq_EML_Mouse1.89210831
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79458732
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76061115
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74041118
22RACK7_27058665_Chip-Seq_MCF-7_Human1.68926959
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66267176
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.62946690
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.59914935
26ATF3_27146783_Chip-Seq_COLON_Human1.56224615
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.56108388
28* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53187413
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53127276
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52452804
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51077631
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50948730
33* XRN2_22483619_ChIP-Seq_HELA_Human1.50462451
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50330568
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47325506
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.47152589
37MAF_26560356_Chip-Seq_TH1_Human1.46404495
38* SMC4_20622854_ChIP-Seq_HELA_Human1.46338793
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40471132
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40095608
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38793119
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38594163
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38260552
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38223269
45UTX_26944678_Chip-Seq_JUKART_Human1.37800854
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37000681
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36426176
48VDR_24763502_ChIP-Seq_THP-1_Human1.35758396
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.34373606
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33453973
51TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33097734
52* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32693338
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.32652443
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.31019906
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30687281
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30396701
57ZNF263_19887448_ChIP-Seq_K562_Human1.29885734
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29634292
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29597967
60NCOR1_26117541_ChIP-Seq_K562_Human1.29135781
61CIITA_25753668_ChIP-Seq_RAJI_Human1.28931109
62KDM2B_26808549_Chip-Seq_K562_Human1.27697248
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27255526
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26817053
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26655301
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.26392209
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25635734
68* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25475041
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.25450925
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24168382
71BCOR_27268052_Chip-Seq_Bcells_Human1.24094390
72TFEB_21752829_ChIP-Seq_HELA_Human1.23902876
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.23277895
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21793396
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21199580
76* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21039187
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20786339
78P68_20966046_ChIP-Seq_HELA_Human1.19416164
79SCL_19346495_ChIP-Seq_HPC-7_Human1.17716731
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17569368
81RUNX1_27514584_Chip-Seq_MCF-7_Human1.16411256
82TP53_22127205_ChIP-Seq_IMR90_Human1.14868727
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14749423
84EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14179305
85FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13999722
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13519052
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12142688
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12116807
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11787101
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11069674
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10065641
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09556617
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09333484
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09273229
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08673865
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08450416
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07609066
98CREB1_26743006_Chip-Seq_LNCaP_Human1.07532295
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07461171
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07312999
101SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07107383
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05588179
103MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05520722
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05193732
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04922179
106SA1_27219007_Chip-Seq_ERYTHROID_Human1.04620871
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04422347
108MAF_26560356_Chip-Seq_TH2_Human1.04099307
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03946530
110* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03881647
111FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03106510
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02786921
113TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01928575
114BCL6_27268052_Chip-Seq_Bcells_Human1.01799900
115* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01758607
116* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01105646
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00921301
118PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00209667
119FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99529533
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99431198
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99233564
122SPI1_23127762_ChIP-Seq_K562_Human0.99130254
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97927026
124CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97795380
125DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96977344
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96212497
127TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95236100
128RUNX1_22412390_ChIP-Seq_EML_Mouse0.94316640
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94127634
130SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93317849
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92623161
132HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91709062
133NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91513611
134RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91486611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.74730821
2MP0008438_abnormal_cutaneous_collagen3.46033126
3MP0003303_peritoneal_inflammation3.00134849
4MP0005451_abnormal_body_composition2.99966978
5MP0010352_gastrointestinal_tract_polyps2.93376727
6MP0009278_abnormal_bone_marrow2.63423972
7MP0008260_abnormal_autophagy2.59695080
8MP0005076_abnormal_cell_differentiation2.32986058
9MP0003279_aneurysm2.32525268
10MP0003566_abnormal_cell_adhesion2.27159623
11MP0003763_abnormal_thymus_physiology2.20330481
12MP0006054_spinal_hemorrhage2.20034496
13MP0003191_abnormal_cellular_cholesterol2.07161266
14MP0005023_abnormal_wound_healing2.03978430
15MP0001849_ear_inflammation2.02226933
16MP0010030_abnormal_orbit_morphology2.02154811
17MP0002653_abnormal_ependyma_morphology1.98267068
18MP0000537_abnormal_urethra_morphology1.93408561
19MP0004185_abnormal_adipocyte_glucose1.93049615
20MP0003122_maternal_imprinting1.88523774
21MP0004858_abnormal_nervous_system1.84876624
22MP0003123_paternal_imprinting1.79672386
23MP0003300_gastrointestinal_ulcer1.79215835
24MP0003453_abnormal_keratinocyte_physiol1.78612756
25MP0002877_abnormal_melanocyte_morpholog1.73682624
26MP0008961_abnormal_basal_metabolism1.73420220
27MP0005275_abnormal_skin_tensile1.73183868
28MP0004272_abnormal_basement_membrane1.71927629
29MP0003283_abnormal_digestive_organ1.70810991
30MP0001835_abnormal_antigen_presentation1.70550685
31MP0005000_abnormal_immune_tolerance1.69846477
32MP0001958_emphysema1.67216405
33MP0002089_abnormal_postnatal_growth/wei1.63217533
34MP0005025_abnormal_response_to1.61586429
35MP0002419_abnormal_innate_immunity1.61173822
36MP0003091_abnormal_cell_migration1.59819428
37MP0000733_abnormal_muscle_development1.57720459
38MP0005666_abnormal_adipose_tissue1.54775783
39MP0001730_embryonic_growth_arrest1.53301578
40MP0004510_myositis1.53194995
41MP0005623_abnormal_meninges_morphology1.52048886
42MP0001790_abnormal_immune_system1.51446599
43MP0005387_immune_system_phenotype1.51446599
44MP0001800_abnormal_humoral_immune1.51228213
45MP0009053_abnormal_anal_canal1.49336873
46MP0001545_abnormal_hematopoietic_system1.47922461
47MP0005397_hematopoietic_system_phenotyp1.47922461
48MP0010368_abnormal_lymphatic_system1.46426707
49MP0001873_stomach_inflammation1.38472824
50MP0002723_abnormal_immune_serum1.37900469
51MP0002420_abnormal_adaptive_immunity1.37070295
52MP0000350_abnormal_cell_proliferation1.36946882
53MP0010155_abnormal_intestine_physiology1.36564814
54MP0001819_abnormal_immune_cell1.36438541
55MP0000767_abnormal_smooth_muscle1.35108387
56MP0004808_abnormal_hematopoietic_stem1.35073369
57MP0005409_darkened_coat_color1.34451579
58MP0000428_abnormal_craniofacial_morphol1.33808243
59MP0005503_abnormal_tendon_morphology1.32489854
60MP0002452_abnormal_antigen_presenting1.32461251
61MP0003724_increased_susceptibility_to1.32279098
62MP0002398_abnormal_bone_marrow1.31735550
63MP0004381_abnormal_hair_follicle1.31368610
64MP0002998_abnormal_bone_remodeling1.28973175
65MP0000858_altered_metastatic_potential1.28941315
66MP0003115_abnormal_respiratory_system1.28607121
67MP0003329_amyloid_beta_deposits1.27449604
68MP0004957_abnormal_blastocyst_morpholog1.26690487
69MP0002088_abnormal_embryonic_growth/wei1.25087917
70MP0005257_abnormal_intraocular_pressure1.24383814
71MP0003984_embryonic_growth_retardation1.23986867
72MP0008007_abnormal_cellular_replicative1.23858573
73MP0003942_abnormal_urinary_system1.23624123
74MP0002796_impaired_skin_barrier1.21650058
75MP0000703_abnormal_thymus_morphology1.19972518
76MP0003172_abnormal_lysosome_physiology1.19172950
77MP0001915_intracranial_hemorrhage1.18488806
78MP0000716_abnormal_immune_system1.16957105
79MP0002396_abnormal_hematopoietic_system1.16835541
80MP0005464_abnormal_platelet_physiology1.16804092
81MP0000534_abnormal_ureter_morphology1.15990783
82MP0004197_abnormal_fetal_growth/weight/1.15825756
83MP0003436_decreased_susceptibility_to1.14425927
84* MP0002080_prenatal_lethality1.14420911
85MP0009840_abnormal_foam_cell1.14067812
86MP0001672_abnormal_embryogenesis/_devel1.13984167
87MP0005380_embryogenesis_phenotype1.13984167
88MP0002084_abnormal_developmental_patter1.12380369
89MP0001697_abnormal_embryo_size1.12314483
90MP0005058_abnormal_lysosome_morphology1.12147922
91MP0002405_respiratory_system_inflammati1.12025663
92MP0003448_altered_tumor_morphology1.11907706
93MP0003111_abnormal_nucleus_morphology1.11094750
94MP0000678_abnormal_parathyroid_gland1.09998554
95MP0002086_abnormal_extraembryonic_tissu1.09616606
96MP0002085_abnormal_embryonic_tissue1.09437382
97MP0002933_joint_inflammation1.09224064
98MP0005671_abnormal_response_to1.09199630
99MP0003077_abnormal_cell_cycle1.07912567
100MP0003385_abnormal_body_wall1.05794853
101MP0002722_abnormal_immune_system1.05569940
102MP0002925_abnormal_cardiovascular_devel1.04783893
103MP0003183_abnormal_peptide_metabolism1.04133737
104MP0001348_abnormal_lacrimal_gland1.03362654
105MP0003119_abnormal_digestive_system1.03076309
106MP0003075_altered_response_to1.02717907
107* MP0002429_abnormal_blood_cell1.02473243
108MP0001533_abnormal_skeleton_physiology1.01894845
109MP0000604_amyloidosis1.01586260
110MP0000751_myopathy1.00056277
111MP0010234_abnormal_vibrissa_follicle0.99225326
112MP0005508_abnormal_skeleton_morphology0.98528594
113MP0001851_eye_inflammation0.97565960
114MP0002249_abnormal_larynx_morphology0.96347244
115MP0009785_altered_susceptibility_to0.96309879
116MP0001853_heart_inflammation0.96145074
117MP0000003_abnormal_adipose_tissue0.96136016
118MP0000490_abnormal_crypts_of0.94396065
119MP0002282_abnormal_trachea_morphology0.93500057
120MP0002148_abnormal_hypersensitivity_rea0.92890656
121MP0010307_abnormal_tumor_latency0.92746768
122MP0002060_abnormal_skin_morphology0.92141343
123MP0009333_abnormal_splenocyte_physiolog0.91624253
124MP0005501_abnormal_skin_physiology0.91528107
125MP0006082_CNS_inflammation0.91498062
126MP0001243_abnormal_dermal_layer0.91237788
127MP0000685_abnormal_immune_system0.90866332
128MP0004264_abnormal_extraembryonic_tissu0.89718511
129MP0001614_abnormal_blood_vessel0.89549760
130MP0002166_altered_tumor_susceptibility0.88823713
131MP0003121_genomic_imprinting0.88338065
132MP0005390_skeleton_phenotype0.88327446
133MP0005310_abnormal_salivary_gland0.87743097
134MP0001845_abnormal_inflammatory_respons0.87586148
135MP0003690_abnormal_glial_cell0.87520215
136MP0000689_abnormal_spleen_morphology0.87485761
137MP0003866_abnormal_defecation0.87114099
138MP0004947_skin_inflammation0.85997125
139MP0000747_muscle_weakness0.85900639
140MP0005167_abnormal_blood-brain_barrier0.84877168
141MP0009931_abnormal_skin_appearance0.83767169
142MP0008932_abnormal_embryonic_tissue0.82845217
143MP0000750_abnormal_muscle_regeneration0.80832298
144MP0002128_abnormal_blood_circulation0.80395689
145MP0000465_gastrointestinal_hemorrhage0.79966503
146MP0000477_abnormal_intestine_morphology0.79144818
147MP0005621_abnormal_cell_physiology0.77878966
148MP0003567_abnormal_fetal_cardiomyocyte0.76052765
149MP0000759_abnormal_skeletal_muscle0.75524671
150MP0002932_abnormal_joint_morphology0.75170311
151MP0004233_abnormal_muscle_weight0.75058515
152MP0002009_preneoplasia0.74413399
153MP0008770_decreased_survivor_rate0.73808932
154MP0000313_abnormal_cell_death0.72563138
155MP0009672_abnormal_birth_weight0.71954339
156MP0005375_adipose_tissue_phenotype0.71185555
157MP0000266_abnormal_heart_morphology0.70499354
158MP0003828_pulmonary_edema0.69208586
159MP0005384_cellular_phenotype0.68926762
160MP0002019_abnormal_tumor_incidence0.68259213
161MP0000358_abnormal_cell_content/0.67695558

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.10178851
2Cerebral aneurysm (HP:0004944)3.99771820
3Premature rupture of membranes (HP:0001788)3.77641491
4Hyperacusis (HP:0010780)3.54290799
5Shallow orbits (HP:0000586)3.40575449
6Ankle contracture (HP:0006466)3.40426505
7Obstructive sleep apnea (HP:0002870)3.36150767
8Eczematoid dermatitis (HP:0000976)3.32954545
9Hand muscle atrophy (HP:0009130)3.10119206
10Renal duplication (HP:0000075)2.94025219
11Vertebral compression fractures (HP:0002953)2.90023148
12Dilatation of the ascending aorta (HP:0005111)2.88977357
13Upper limb amyotrophy (HP:0009129)2.85931540
14Distal upper limb amyotrophy (HP:0007149)2.85931540
15Aortic aneurysm (HP:0004942)2.78563410
16Bladder diverticulum (HP:0000015)2.72465790
17Aortic dissection (HP:0002647)2.65626780
18Peritonitis (HP:0002586)2.64780405
19Bowel diverticulosis (HP:0005222)2.63250752
20Cellulitis (HP:0100658)2.63156920
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.61406237
22Short 4th metacarpal (HP:0010044)2.61406237
23Colitis (HP:0002583)2.59984963
24Distal lower limb amyotrophy (HP:0008944)2.57876590
25Genu recurvatum (HP:0002816)2.53574657
26Dysostosis multiplex (HP:0000943)2.52289211
27Aneurysm (HP:0002617)2.43764422
28Increased IgE level (HP:0003212)2.42850109
29Broad metatarsal (HP:0001783)2.39158877
30Insomnia (HP:0100785)2.39039572
31Neoplasm of the heart (HP:0100544)2.38904588
32Hemorrhage of the eye (HP:0011885)2.36964406
33Abnormality of the fingertips (HP:0001211)2.31400900
34Cervical subluxation (HP:0003308)2.27834284
35Ependymoma (HP:0002888)2.26615772
36Gastrointestinal inflammation (HP:0004386)2.25157637
37Mitral valve prolapse (HP:0001634)2.25072644
38Abnormality of macrophages (HP:0004311)2.24793240
39Radial bowing (HP:0002986)2.24233246
40Striae distensae (HP:0001065)2.23589326
41Distal lower limb muscle weakness (HP:0009053)2.21559704
42Stridor (HP:0010307)2.20947458
43Centrally nucleated skeletal muscle fibers (HP:0003687)2.20804562
44Ulnar bowing (HP:0003031)2.20769792
45Abnormality of the lower motor neuron (HP:0002366)2.19248555
46Recurrent abscess formation (HP:0002722)2.18926119
47Abnormality of the 4th metacarpal (HP:0010012)2.16566061
48Diminished motivation (HP:0000745)2.16549749
49Wrist flexion contracture (HP:0001239)2.15006400
50Lymphangioma (HP:0100764)2.12724659
51Recurrent bacterial skin infections (HP:0005406)2.12206772
52Pointed chin (HP:0000307)2.10239836
53Increased cerebral lipofuscin (HP:0011813)2.09960795
54Emphysema (HP:0002097)2.09344459
55Apathy (HP:0000741)2.07743918
56Selective tooth agenesis (HP:0001592)2.07444617
57Atrophic scars (HP:0001075)2.07053405
58Flat acetabular roof (HP:0003180)2.06659290
59Deviation of the hallux (HP:0010051)2.06523351
60Polygenic inheritance (HP:0010982)2.06213312
61Broad palm (HP:0001169)2.06165479
62J-shaped sella turcica (HP:0002680)2.05378332
63Hallux valgus (HP:0001822)2.05104761
64Broad face (HP:0000283)2.04327682
65Mucopolysacchariduria (HP:0008155)2.03525366
66Urinary glycosaminoglycan excretion (HP:0003541)2.03525366
67Neuronal loss in central nervous system (HP:0002529)2.00412644
68Blue sclerae (HP:0000592)2.00352679
69Abnormality of polysaccharide metabolism (HP:0011012)2.00314589
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00314589
71Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00314589
72Gastrointestinal stroma tumor (HP:0100723)2.00117210
73Limb-girdle muscle atrophy (HP:0003797)1.98769268
74Metaphyseal cupping (HP:0003021)1.98576704
75Gingivitis (HP:0000230)1.98039028
76Thin bony cortex (HP:0002753)1.97498603
77Increased variability in muscle fiber diameter (HP:0003557)1.97100463
78Supranuclear gaze palsy (HP:0000605)1.95932961
79Achilles tendon contracture (HP:0001771)1.95871081
80Recurrent viral infections (HP:0004429)1.95647194
81Inflammation of the large intestine (HP:0002037)1.95057436
82Abnormality of the calcaneus (HP:0008364)1.95050521
83Slow saccadic eye movements (HP:0000514)1.94191821
84Bicuspid aortic valve (HP:0001647)1.93724529
85Overriding aorta (HP:0002623)1.93564892
86Fragile skin (HP:0001030)1.92037031
87Elfin facies (HP:0004428)1.91570148
88Disproportionate tall stature (HP:0001519)1.90577496
89Long toe (HP:0010511)1.89822256
90Abnormality of the thoracic spine (HP:0100711)1.89718818
91Abnormality of glycolipid metabolism (HP:0010969)1.88177382
92Abnormality of liposaccharide metabolism (HP:0010968)1.88177382
93Abnormality of glycosphingolipid metabolism (HP:0004343)1.88177382
94Hypercortisolism (HP:0001578)1.87743138
95Cerebral inclusion bodies (HP:0100314)1.86962133
96Segmental peripheral demyelination/remyelination (HP:0003481)1.85877281
97Spinal cord lesions (HP:0100561)1.85350689
98Syringomyelia (HP:0003396)1.85350689
99Bowing of the arm (HP:0006488)1.85228393
100Bowed forearm bones (HP:0003956)1.85228393
101Soft skin (HP:0000977)1.85192724
102Increased nuchal translucency (HP:0010880)1.84896031
103Abnormality of the peritoneum (HP:0002585)1.84577255
104Myopathic facies (HP:0002058)1.84394976
105Easy fatigability (HP:0003388)1.84267155
106Increased connective tissue (HP:0009025)1.83867737
107Myositis (HP:0100614)1.80326580
108Asymmetric septal hypertrophy (HP:0001670)1.80288766
109Mediastinal lymphadenopathy (HP:0100721)1.78509149
110Camptodactyly of toe (HP:0001836)1.78492381
111Biconcave vertebral bodies (HP:0004586)1.78384868
112Abnormality of skeletal muscle fiber size (HP:0012084)1.77837531
113Loss of speech (HP:0002371)1.77681292
114Increased density of long bones (HP:0006392)1.77648813
115Hypertriglyceridemia (HP:0002155)1.77222090
116Trismus (HP:0000211)1.77053432
117Nuclear cataract (HP:0100018)1.76794769
118Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75622927
119Abnormality of the acetabulum (HP:0003170)1.75142400
120Meningitis (HP:0001287)1.74560803
121Obstructive lung disease (HP:0006536)1.74136375
122Chronic obstructive pulmonary disease (HP:0006510)1.74136375
123Neurofibrillary tangles (HP:0002185)1.73790988
124Increased neuronal autofluorescent lipopigment (HP:0002074)1.73553715
125Interstitial pulmonary disease (HP:0006530)1.73464011
126Abnormality of the anterior horn cell (HP:0006802)1.73342585
127Degeneration of anterior horn cells (HP:0002398)1.73342585
128Flat cornea (HP:0007720)1.73008806
129Renovascular hypertension (HP:0100817)1.71941509
130Abnormality of the distal phalanges of the toes (HP:0010182)1.71543727
131Mitral regurgitation (HP:0001653)1.71193968
132Abnormality of the Achilles tendon (HP:0005109)1.71095962
133Lower limb amyotrophy (HP:0007210)1.70866392
134Adducted thumb (HP:0001181)1.69960693
135Dislocated radial head (HP:0003083)1.69265649
136Thoracic kyphosis (HP:0002942)1.69135381
137Abnormal neuron morphology (HP:0012757)1.68785420
138Abnormality of the motor neurons (HP:0002450)1.68785420
139Hyperextensible skin (HP:0000974)1.68641780
140Axonal loss (HP:0003447)1.67769363
141Long palpebral fissure (HP:0000637)1.67284710
142Reticulocytosis (HP:0001923)1.66372026
143Spontaneous hematomas (HP:0007420)1.66304869
144Recurrent fungal infections (HP:0002841)1.66152898
145Exercise-induced myalgia (HP:0003738)1.66138868
146Nonimmune hydrops fetalis (HP:0001790)1.65928830
147Multiple enchondromatosis (HP:0005701)1.65879575
148Hypertensive crisis (HP:0100735)1.65175024
149Pustule (HP:0200039)1.65129709
150Joint stiffness (HP:0001387)1.64307088
151Gastrointestinal infarctions (HP:0005244)1.64192309
152Adenoma sebaceum (HP:0009720)1.64090416
153Angiofibromas (HP:0010615)1.64090416
154Difficulty climbing stairs (HP:0003551)1.64069091
155Deep venous thrombosis (HP:0002625)1.63569535
156Fibroma (HP:0010614)1.63182798
157Deviation of the thumb (HP:0009603)1.62970453
158Annular pancreas (HP:0001734)1.61602181
159Enlarged penis (HP:0000040)1.61584757
160Wormian bones (HP:0002645)1.61237786
161Abnormality of the nasal mucosa (HP:0000433)1.60839600
162Broad thumb (HP:0011304)1.60171845
163Increased serum ferritin (HP:0003281)1.59822506
164Abnormality of dentin (HP:0010299)1.59276401
165Back pain (HP:0003418)1.58396113
166Osteopenia (HP:0000938)1.58284383
167Coxa vara (HP:0002812)1.58111106
168Skin tags (HP:0010609)1.56057281
169Proximal placement of thumb (HP:0009623)1.55607449
170Osteolytic defects of the hand bones (HP:0009699)1.54522104
171Osteolytic defects of the phalanges of the hand (HP:0009771)1.54522104
172Abnormality of the astrocytes (HP:0100707)1.53563676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.87046469
2PKN24.01349479
3PRPF4B3.64185109
4EEF2K3.25511781
5SMG13.25093852
6ERN13.10267388
7TESK22.31828490
8MAP3K102.15789189
9RIPK12.09528199
10IRAK32.08897951
11PAK42.03984133
12CDK122.00121756
13PDGFRA1.91604950
14RIPK41.91542750
15TESK11.89561951
16SCYL21.83480278
17PTK61.80201231
18MAP3K131.74343429
19NEK11.71715848
20LRRK21.66256411
21MAP3K111.58574323
22TTN1.54575944
23TGFBR11.52037411
24PIM21.50428438
25LIMK11.49165355
26TBK11.48294801
27KSR21.46449079
28FLT31.39911445
29SIK21.34966533
30MAPKAPK31.34127545
31TAOK11.32606451
32DDR21.32198605
33TYK21.31160498
34MAP3K141.30251449
35MAP2K31.26912859
36TNK21.24257195
37IRAK41.23284140
38CDC42BPA1.18146334
39PRKD21.17573602
40LATS21.16811723
41TAOK21.15613984
42PTK21.14421190
43TGFBR21.13597415
44MAP2K21.12968003
45TYRO31.12428269
46SIK31.11814565
47PAK21.10189235
48STK101.07514918
49RPS6KB21.05784111
50ILK1.04946722
51NEK21.02756296
52MAP4K10.99888903
53ALK0.99244738
54PAK60.98893483
55GRK60.98297590
56MAP3K80.97201401
57PDPK10.94915748
58EPHA20.94264187
59FGFR40.93273885
60FER0.90709462
61RPS6KA20.89812541
62MAP3K60.87520182
63BLK0.86650622
64CSK0.85714022
65MTOR0.84986773
66JAK30.84681642
67IRAK20.84104704
68MAPK120.83838176
69MAPK110.83200931
70BMX0.82614170
71EPHB20.81846525
72RPS6KA40.81747902
73EPHB10.79590296
74RET0.78550062
75HIPK20.78488175
76FES0.78309473
77MAP3K70.78294181
78SIK10.76007253
79ZAP700.73638890
80PAK30.73456198
81BUB10.73268801
82KDR0.72861650
83MATK0.72221678
84ARAF0.71309995
85MST1R0.70973809
86PDK10.69341647
87KSR10.68820974
88NME20.68780316
89JAK10.65936441
90NTRK10.64929735
91PRKD30.64333389
92PAK10.64134586
93DYRK1B0.64036719
94ICK0.63733148
95CDK70.63563738
96HCK0.63435750
97IKBKE0.63070413
98PASK0.62846534
99FGFR10.62748458
100MAPK70.60053627
101CDK60.57915942
102CLK10.55827962
103EPHA30.55519327
104CSF1R0.54635530
105ERBB20.54501826
106MAP3K10.52648415
107DAPK30.52105528
108RAF10.51102366
109MAP3K90.50359014
110FGFR30.49911054
111CAMKK10.49608482
112KIT0.48776450
113PTK2B0.47651095
114CAMK1D0.47196109
115MAP3K30.46919879
116BCKDK0.46176525
117MARK20.45486166
118MAP2K10.43373155
119MINK10.42554034
120CDK140.42192485
121JAK20.41786398
122PRKG20.41525037
123RPS6KA60.41147620
124IKBKB0.40565569
125SGK30.40493500
126CDK40.40388681
127RPS6KL10.40218830
128RPS6KC10.40218830
129BRAF0.39154457
130CDK90.38856767
131AKT20.38589900
132BRD40.38454474
133CHUK0.38272582
134LCK0.37640480
135PDGFRB0.37273484
136MAPK40.36693456
137TSSK60.36196625
138MAP2K60.35654436
139SYK0.35608964
140BTK0.35573355
141FGR0.35478811
142STK380.35392118
143MAPKAPK20.34344666

Predicted pathways (KEGG)

RankGene SetZ-score
1Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.38427655
2Chronic myeloid leukemia_Homo sapiens_hsa052202.15135253
3Shigellosis_Homo sapiens_hsa051311.90656747
4Bladder cancer_Homo sapiens_hsa052191.88407118
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.76351969
6Central carbon metabolism in cancer_Homo sapiens_hsa052301.66192681
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64687977
8Colorectal cancer_Homo sapiens_hsa052101.64274760
9Proteoglycans in cancer_Homo sapiens_hsa052051.61098086
10Neurotrophin signaling pathway_Homo sapiens_hsa047221.61020527
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.59457525
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53852701
13DNA replication_Homo sapiens_hsa030301.45275975
14Focal adhesion_Homo sapiens_hsa045101.43358627
15VEGF signaling pathway_Homo sapiens_hsa043701.42946776
16Endometrial cancer_Homo sapiens_hsa052131.42790212
17Sulfur relay system_Homo sapiens_hsa041221.41562584
18Notch signaling pathway_Homo sapiens_hsa043301.37964653
19Pancreatic cancer_Homo sapiens_hsa052121.37914599
20Hippo signaling pathway_Homo sapiens_hsa043901.35955127
21Small cell lung cancer_Homo sapiens_hsa052221.34716225
22Acute myeloid leukemia_Homo sapiens_hsa052211.34101288
23Thyroid cancer_Homo sapiens_hsa052161.33300002
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.32486755
25T cell receptor signaling pathway_Homo sapiens_hsa046601.30557151
26Leishmaniasis_Homo sapiens_hsa051401.28061927
27mTOR signaling pathway_Homo sapiens_hsa041501.27432206
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25445495
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23820578
30Apoptosis_Homo sapiens_hsa042101.23053639
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.20236437
32MicroRNAs in cancer_Homo sapiens_hsa052061.18155842
33Hepatitis C_Homo sapiens_hsa051601.17601330
34Basal cell carcinoma_Homo sapiens_hsa052171.17553505
35Non-small cell lung cancer_Homo sapiens_hsa052231.17131057
36Salmonella infection_Homo sapiens_hsa051321.13256250
37GnRH signaling pathway_Homo sapiens_hsa049121.12652767
38Spliceosome_Homo sapiens_hsa030401.11742022
39B cell receptor signaling pathway_Homo sapiens_hsa046621.11721378
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11009673
41Legionellosis_Homo sapiens_hsa051341.10544823
42Endocytosis_Homo sapiens_hsa041441.09899851
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09300298
44Glioma_Homo sapiens_hsa052141.08770900
45Lysosome_Homo sapiens_hsa041421.08343942
46* HTLV-I infection_Homo sapiens_hsa051661.07592372
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07113481
48Adherens junction_Homo sapiens_hsa045201.06105757
49Toxoplasmosis_Homo sapiens_hsa051451.05157309
50Fructose and mannose metabolism_Homo sapiens_hsa000511.05026532
51ErbB signaling pathway_Homo sapiens_hsa040121.04743389
52Choline metabolism in cancer_Homo sapiens_hsa052311.03133300
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02747440
54ECM-receptor interaction_Homo sapiens_hsa045121.02059858
55Hedgehog signaling pathway_Homo sapiens_hsa043401.01495901
56Amoebiasis_Homo sapiens_hsa051461.01141561
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00083739
58Hepatitis B_Homo sapiens_hsa051610.99711977
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99422015
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99141799
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.99014766
62* Cell cycle_Homo sapiens_hsa041100.98628604
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98342786
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97454740
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97406126
66Viral myocarditis_Homo sapiens_hsa054160.95260618
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94449520
68Measles_Homo sapiens_hsa051620.93895200
69RNA transport_Homo sapiens_hsa030130.93665599
70Base excision repair_Homo sapiens_hsa034100.93285008
71Osteoclast differentiation_Homo sapiens_hsa043800.92863557
72* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92784229
73Renal cell carcinoma_Homo sapiens_hsa052110.92459333
74Inositol phosphate metabolism_Homo sapiens_hsa005620.92235357
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92179536
76Primary immunodeficiency_Homo sapiens_hsa053400.91601513
77HIF-1 signaling pathway_Homo sapiens_hsa040660.88403831
78Epstein-Barr virus infection_Homo sapiens_hsa051690.88364103
79Pathways in cancer_Homo sapiens_hsa052000.87903188
80TNF signaling pathway_Homo sapiens_hsa046680.87047984
81p53 signaling pathway_Homo sapiens_hsa041150.87026511
82Platelet activation_Homo sapiens_hsa046110.86234849
83Pertussis_Homo sapiens_hsa051330.85592776
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.85332878
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84717458
86Chemokine signaling pathway_Homo sapiens_hsa040620.84147113
87Prostate cancer_Homo sapiens_hsa052150.83176170
88One carbon pool by folate_Homo sapiens_hsa006700.82742426
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81447096
90Biosynthesis of amino acids_Homo sapiens_hsa012300.80522126
91Staphylococcus aureus infection_Homo sapiens_hsa051500.80461924
92mRNA surveillance pathway_Homo sapiens_hsa030150.80217023
93Antigen processing and presentation_Homo sapiens_hsa046120.78781881
94N-Glycan biosynthesis_Homo sapiens_hsa005100.78208381
95Prolactin signaling pathway_Homo sapiens_hsa049170.77941313
96TGF-beta signaling pathway_Homo sapiens_hsa043500.77821741
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76353343
98Malaria_Homo sapiens_hsa051440.75370658
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75187459
100Rap1 signaling pathway_Homo sapiens_hsa040150.74999467
101Long-term potentiation_Homo sapiens_hsa047200.73787620
102Insulin resistance_Homo sapiens_hsa049310.73215746
103Influenza A_Homo sapiens_hsa051640.72004468
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.71357378
105Prion diseases_Homo sapiens_hsa050200.71176576
106Tuberculosis_Homo sapiens_hsa051520.70628952
107Viral carcinogenesis_Homo sapiens_hsa052030.69171594
108Galactose metabolism_Homo sapiens_hsa000520.69131007
109Estrogen signaling pathway_Homo sapiens_hsa049150.68867925
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.68558484
111Insulin signaling pathway_Homo sapiens_hsa049100.67134054
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66805012
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66021397
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63937657
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.63359803
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62192035
117FoxO signaling pathway_Homo sapiens_hsa040680.61923984
118* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61688312
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60681157
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60268470
121AMPK signaling pathway_Homo sapiens_hsa041520.60243952
122Herpes simplex infection_Homo sapiens_hsa051680.60006968
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.59945442
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58083023
125Gap junction_Homo sapiens_hsa045400.57987013
126Protein digestion and absorption_Homo sapiens_hsa049740.57975363
127Pentose phosphate pathway_Homo sapiens_hsa000300.57632449
128MAPK signaling pathway_Homo sapiens_hsa040100.57490848
129Other glycan degradation_Homo sapiens_hsa005110.57354538
130* Oocyte meiosis_Homo sapiens_hsa041140.57249035
131Allograft rejection_Homo sapiens_hsa053300.56043533
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51817422
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50183030
134Autoimmune thyroid disease_Homo sapiens_hsa053200.49344372
135Lysine degradation_Homo sapiens_hsa003100.48856390

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