ANAPC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.19572993
2cilium or flagellum-dependent cell motility (GO:0001539)5.08172393
3DNA double-strand break processing (GO:0000729)4.87955614
4negative regulation of DNA recombination (GO:0045910)4.32277934
5synapsis (GO:0007129)4.29315863
6negative regulation of DNA-dependent DNA replication (GO:2000104)4.05781864
7mitotic G2/M transition checkpoint (GO:0044818)3.97565386
8mitotic G2 DNA damage checkpoint (GO:0007095)3.80813119
9COPI coating of Golgi vesicle (GO:0048205)3.69400245
10Golgi transport vesicle coating (GO:0048200)3.69400245
11replication fork processing (GO:0031297)3.69379325
12centriole replication (GO:0007099)3.59424820
13histamine secretion (GO:0001821)3.56178119
14RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.55359615
15rRNA catabolic process (GO:0016075)3.54025617
16IMP biosynthetic process (GO:0006188)3.50159144
17epithelial cilium movement (GO:0003351)3.45110126
18spliceosomal tri-snRNP complex assembly (GO:0000244)3.43400049
19regulation of meiosis I (GO:0060631)3.42983072
20regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.40782151
21regulation of mitotic spindle checkpoint (GO:1903504)3.40782151
22cilium movement (GO:0003341)3.38278671
23regulation of helicase activity (GO:0051095)3.34006839
24histone H2A acetylation (GO:0043968)3.33984717
25neural tube formation (GO:0001841)3.33935788
26maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.33447703
27regulation of DNA endoreduplication (GO:0032875)3.31211409
28axonemal dynein complex assembly (GO:0070286)3.30804751
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.29548135
30cullin deneddylation (GO:0010388)3.27745700
31somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.27504229
32isotype switching (GO:0045190)3.27504229
33somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.27504229
34double-strand break repair via nonhomologous end joining (GO:0006303)3.27020331
35non-recombinational repair (GO:0000726)3.27020331
36purine nucleobase biosynthetic process (GO:0009113)3.25690628
37DNA catabolic process, exonucleolytic (GO:0000738)3.22415391
38positive regulation of histone H3-K4 methylation (GO:0051571)3.21102741
39double-strand break repair via homologous recombination (GO:0000724)3.17532969
40recombinational repair (GO:0000725)3.13797066
41* mitotic spindle assembly checkpoint (GO:0007094)3.11943140
42ribosome assembly (GO:0042255)3.10370832
43positive regulation of alpha-beta T cell proliferation (GO:0046641)3.10028775
44* spindle checkpoint (GO:0031577)3.09417600
45* spindle assembly checkpoint (GO:0071173)3.06112632
46establishment of protein localization to Golgi (GO:0072600)3.03994236
47sister chromatid cohesion (GO:0007062)3.02778873
48DNA unwinding involved in DNA replication (GO:0006268)3.02608283
49paraxial mesoderm development (GO:0048339)2.99100046
50* negative regulation of mitotic sister chromatid separation (GO:2000816)2.98790986
51* negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98790986
52* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98790986
53* negative regulation of sister chromatid segregation (GO:0033046)2.98790986
54* mitotic spindle checkpoint (GO:0071174)2.95903290
55N-terminal protein amino acid acetylation (GO:0006474)2.95340334
56* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93735318
57sequestering of extracellular ligand from receptor (GO:0035581)2.93223897
58IMP metabolic process (GO:0046040)2.92817726
59G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.92310015
60mitotic chromosome condensation (GO:0007076)2.91908503
61protein targeting to Golgi (GO:0000042)2.91793451
62* negative regulation of chromosome segregation (GO:0051985)2.90199124
63protein deneddylation (GO:0000338)2.88522310
64nucleobase biosynthetic process (GO:0046112)2.87899093
65interkinetic nuclear migration (GO:0022027)2.87796173
66mitotic sister chromatid cohesion (GO:0007064)2.86211164
67nuclear pore organization (GO:0006999)2.85627155
68histone mRNA metabolic process (GO:0008334)2.85385545
69mitotic metaphase plate congression (GO:0007080)2.84765418
70spliceosomal complex assembly (GO:0000245)2.84603567
71somatic diversification of immunoglobulins (GO:0016445)2.81673269
72peptidyl-arginine omega-N-methylation (GO:0035247)2.81563931
73proteasome assembly (GO:0043248)2.79480644
74* regulation of mitotic metaphase/anaphase transition (GO:0030071)2.78174524
75protein localization to kinetochore (GO:0034501)2.77703716
76response to X-ray (GO:0010165)2.77130654
77histone mRNA catabolic process (GO:0071044)2.76043326
78male meiosis I (GO:0007141)2.75411954
79piRNA metabolic process (GO:0034587)2.75267440
80CENP-A containing nucleosome assembly (GO:0034080)2.75107937
81* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74774045
82DNA strand renaturation (GO:0000733)2.73617428
83somatic recombination of immunoglobulin gene segments (GO:0016447)2.72838846
84regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72634236
85cell wall macromolecule metabolic process (GO:0044036)2.70185827
86axon extension involved in axon guidance (GO:0048846)2.70073968
87neuron projection extension involved in neuron projection guidance (GO:1902284)2.70073968
88double-strand break repair (GO:0006302)2.69989248
89centriole assembly (GO:0098534)2.68041830
90mitotic recombination (GO:0006312)2.67949334
91telomere maintenance via recombination (GO:0000722)2.67942341
92negative regulation of mRNA metabolic process (GO:1903312)2.67796069
93planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67716196
94regulation of spindle organization (GO:0090224)2.67451301
95somatic diversification of immune receptors (GO:0002200)2.67415877
96histamine transport (GO:0051608)2.66887610
97regulation of centrosome duplication (GO:0010824)2.66544505
98chromatin remodeling at centromere (GO:0031055)2.66381630
99DNA ligation (GO:0006266)2.64654290
100protein prenylation (GO:0018342)2.63962736
101prenylation (GO:0097354)2.63962736
102translesion synthesis (GO:0019985)2.63951075
103* regulation of sister chromatid segregation (GO:0033045)2.63865643
104* regulation of mitotic sister chromatid separation (GO:0010965)2.63865643
105* regulation of mitotic sister chromatid segregation (GO:0033047)2.63865643
106nuclear pore complex assembly (GO:0051292)2.62830148
107sister chromatid segregation (GO:0000819)2.62000382
108negative regulation of catenin import into nucleus (GO:0035414)2.61706456
109ncRNA catabolic process (GO:0034661)2.61477611
110chondrocyte proliferation (GO:0035988)2.60898809
111somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.59962425
112somatic cell DNA recombination (GO:0016444)2.59962425
113mitotic nuclear envelope disassembly (GO:0007077)2.58438765
114peptidyl-arginine N-methylation (GO:0035246)2.57302252
115peptidyl-arginine methylation (GO:0018216)2.57302252
116histone arginine methylation (GO:0034969)2.57043954
117formation of translation preinitiation complex (GO:0001731)2.56662075
118* regulation of chromosome segregation (GO:0051983)2.55728185
119peptidyl-lysine dimethylation (GO:0018027)2.55259597
120DNA replication-independent nucleosome organization (GO:0034724)2.53909266
121DNA replication-independent nucleosome assembly (GO:0006336)2.53909266
122metaphase plate congression (GO:0051310)2.51443282
123membrane disassembly (GO:0030397)2.50602786
124nuclear envelope disassembly (GO:0051081)2.50602786
125mitotic sister chromatid segregation (GO:0000070)2.43782630
126notochord development (GO:0030903)2.42722296
127kinetochore organization (GO:0051383)2.40929044
128NIK/NF-kappaB signaling (GO:0038061)2.40786988
129* negative regulation of mitosis (GO:0045839)2.40051897
130postreplication repair (GO:0006301)2.39701369
131attachment of spindle microtubules to kinetochore (GO:0008608)2.39380283
132* negative regulation of nuclear division (GO:0051784)2.37243716
133ganglion development (GO:0061548)2.36820150
134regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.35206797
135negative regulation of fibroblast apoptotic process (GO:2000270)2.33216357
136regulation of mitotic spindle organization (GO:0060236)2.32095633
137negative regulation of meiosis (GO:0045835)2.31652408
138monoubiquitinated protein deubiquitination (GO:0035520)2.31163864
139negative regulation of DNA repair (GO:0045738)2.29991391
140positive regulation of male gonad development (GO:2000020)2.29086951
141* protein K11-linked ubiquitination (GO:0070979)2.29083797
142DNA replication-dependent nucleosome organization (GO:0034723)2.28840971
143DNA replication-dependent nucleosome assembly (GO:0006335)2.28840971
144regulation of translational termination (GO:0006449)2.28797831
145histone exchange (GO:0043486)2.28746652
146establishment of chromosome localization (GO:0051303)2.28541513
147negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.27858350
148mitotic cytokinesis (GO:0000281)2.27784562
149regulation of centriole replication (GO:0046599)2.25036312
150somatic diversification of immune receptors via somatic mutation (GO:0002566)2.23150400
151somatic hypermutation of immunoglobulin genes (GO:0016446)2.23150400
152hippo signaling (GO:0035329)2.19528764
153mismatch repair (GO:0006298)2.18864099
154histone-serine phosphorylation (GO:0035404)2.18649218
155ribonucleoprotein complex disassembly (GO:0032988)2.18372269
156histone H2A ubiquitination (GO:0033522)2.17141629
157DNA replication checkpoint (GO:0000076)2.15920054
158negative regulation of JAK-STAT cascade (GO:0046426)2.14928475
159mitotic spindle organization (GO:0007052)2.14711756
160spliceosomal snRNP assembly (GO:0000387)2.13331027
161de novo protein folding (GO:0006458)2.12301022
162chromosome segregation (GO:0007059)2.11397656
163* negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.10509324
164intra-S DNA damage checkpoint (GO:0031573)2.10362207
165intraciliary transport (GO:0042073)2.09156101
166* negative regulation of cell division (GO:0051782)2.07915126
167lens morphogenesis in camera-type eye (GO:0002089)2.06695082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.87189689
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.49322297
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.12739415
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.39975829
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.25569883
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.22799778
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.97279780
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81488256
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.70333495
10* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.52769269
11PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28191957
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27703818
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27478116
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24728351
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22119938
16ZNF274_21170338_ChIP-Seq_K562_Hela2.18827960
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.17780268
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12719768
19ELK1_19687146_ChIP-ChIP_HELA_Human2.11290808
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.03175446
21YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00586182
22VDR_22108803_ChIP-Seq_LS180_Human1.99431629
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.94640692
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92760597
25TAF15_26573619_Chip-Seq_HEK293_Human1.89721045
26AR_21909140_ChIP-Seq_LNCAP_Human1.86993576
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74678865
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72372811
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69081021
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65452006
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.65199909
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63524222
33P300_19829295_ChIP-Seq_ESCs_Human1.62729509
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62637677
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62510709
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62065421
37* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61317909
38FUS_26573619_Chip-Seq_HEK293_Human1.60413160
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58652801
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57872391
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57628660
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.56439827
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.54099319
44CIITA_25753668_ChIP-Seq_RAJI_Human1.53732054
45* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53148083
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52371198
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.48591066
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47323319
49XRN2_22483619_ChIP-Seq_HELA_Human1.46954551
50IGF1R_20145208_ChIP-Seq_DFB_Human1.46134614
51EWS_26573619_Chip-Seq_HEK293_Human1.46110958
52GABP_19822575_ChIP-Seq_HepG2_Human1.45102627
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44711097
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44353389
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.43417296
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41779955
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.41718173
58ER_23166858_ChIP-Seq_MCF-7_Human1.40828147
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40479198
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40233566
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40071967
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39859155
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38863712
64SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.38792048
65IRF1_19129219_ChIP-ChIP_H3396_Human1.38157053
66VDR_23849224_ChIP-Seq_CD4+_Human1.38155768
67* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36214021
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31385473
69FOXP3_21729870_ChIP-Seq_TREG_Human1.29706047
70MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.29686093
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29684770
72TTF2_22483619_ChIP-Seq_HELA_Human1.27720151
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27318555
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.26908687
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26719154
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.26682261
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26580638
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.25855328
79* DCP1A_22483619_ChIP-Seq_HELA_Human1.25764574
80* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25344766
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25185365
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23434704
83* NANOG_16153702_ChIP-ChIP_HESCs_Human1.22786563
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22126673
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22073788
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21049245
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19095905
88SALL4_22934838_ChIP-ChIP_CD34+_Human1.18206735
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17741434
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16924364
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16387951
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15383311
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14752799
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13602762
95BRD4_25478319_ChIP-Seq_HGPS_Human1.11232912
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10863409
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.07725720
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07289812
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07233253
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.05698774
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05386235
102RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04897024
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04306326
104SMAD4_21799915_ChIP-Seq_A2780_Human1.03744108
105GBX2_23144817_ChIP-Seq_PC3_Human1.03477401
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03345097
107* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03300103
108POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02774904
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02632306
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02558503
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02450444
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01834996
113CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01834687
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01678319
115MYB_26560356_Chip-Seq_TH2_Human1.01355210
116STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00790871
117GATA4_21415370_ChIP-Seq_HL-1_Mouse1.00613293
118* STAT3_23295773_ChIP-Seq_U87_Human1.00044994
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99734537
120CRX_20693478_ChIP-Seq_RETINA_Mouse0.99724101
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99424949
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99363968
123TRIM28_21343339_ChIP-Seq_HEK293_Human0.99297713
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98620505
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98447720
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97600384
127TFEB_21752829_ChIP-Seq_HELA_Human0.97422727
128SOX17_20123909_ChIP-Seq_XEN_Mouse0.97394237
129TCF4_22108803_ChIP-Seq_LS180_Human0.96836912
130NANOG_19829295_ChIP-Seq_ESCs_Human0.94982738
131SOX2_19829295_ChIP-Seq_ESCs_Human0.94982738
132MYC_18940864_ChIP-ChIP_HL60_Human0.94899095
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94731668
134CBP_20019798_ChIP-Seq_JUKART_Human0.93107713
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93107713
136OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92248852
137IRF8_21731497_ChIP-ChIP_J774_Mouse0.92241829
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91877067
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91727657
140ELK1_22589737_ChIP-Seq_MCF10A_Human0.91610072
141TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91407236
142GATA3_26560356_Chip-Seq_TH2_Human0.90393524
143HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90266491
144CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90181135
145KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90035797
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.89778558
147TCF4_23295773_ChIP-Seq_U87_Human0.89718922
148P300_18555785_Chip-Seq_ESCs_Mouse0.89391846
149BCAT_22108803_ChIP-Seq_LS180_Human0.89283868
150CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89231072
151BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88678744
152E2F1_18555785_Chip-Seq_ESCs_Mouse0.87897126
153REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85468254
154CHD1_26751641_Chip-Seq_LNCaP_Human0.84149237
155E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83935273
156EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83732066
157FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83539336
158GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83015213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.51569936
2MP0009697_abnormal_copulation3.09412699
3MP0003123_paternal_imprinting3.08927236
4MP0003122_maternal_imprinting3.05012827
5MP0003121_genomic_imprinting2.98938870
6MP0003195_calcinosis2.82865225
7MP0000569_abnormal_digit_pigmentation2.74710737
8MP0008438_abnormal_cutaneous_collagen2.71368602
9MP0002396_abnormal_hematopoietic_system2.50356855
10MP0000537_abnormal_urethra_morphology2.50302550
11MP0001348_abnormal_lacrimal_gland2.38096499
12MP0005503_abnormal_tendon_morphology2.23376983
13MP0008877_abnormal_DNA_methylation2.23272528
14MP0008995_early_reproductive_senescence2.16734974
15MP0010094_abnormal_chromosome_stability2.08281826
16MP0000013_abnormal_adipose_tissue1.95768043
17MP0003787_abnormal_imprinting1.93035249
18MP0003718_maternal_effect1.92755121
19MP0002138_abnormal_hepatobiliary_system1.89647747
20MP0000383_abnormal_hair_follicle1.88586912
21MP0008932_abnormal_embryonic_tissue1.80867436
22MP0004957_abnormal_blastocyst_morpholog1.80565664
23MP0003693_abnormal_embryo_hatching1.79648981
24MP0001835_abnormal_antigen_presentation1.71009218
25MP0010030_abnormal_orbit_morphology1.70796030
26MP0003111_abnormal_nucleus_morphology1.69251741
27MP0003077_abnormal_cell_cycle1.61716625
28MP0008007_abnormal_cellular_replicative1.57867269
29MP0001299_abnormal_eye_distance/1.57116184
30MP0004084_abnormal_cardiac_muscle1.55772387
31MP0008058_abnormal_DNA_repair1.55560043
32MP0005075_abnormal_melanosome_morpholog1.54931114
33MP0002254_reproductive_system_inflammat1.54613224
34MP0004808_abnormal_hematopoietic_stem1.53993022
35MP0003385_abnormal_body_wall1.52924943
36MP0004742_abnormal_vestibular_system1.52717722
37MP0002009_preneoplasia1.50360037
38MP0003705_abnormal_hypodermis_morpholog1.48907748
39MP0003937_abnormal_limbs/digits/tail_de1.48294388
40MP0004147_increased_porphyrin_level1.44417923
41MP0009780_abnormal_chondrocyte_physiolo1.43413064
42MP0001958_emphysema1.42045168
43MP0003942_abnormal_urinary_system1.40976977
44MP0002084_abnormal_developmental_patter1.38893970
45MP0009384_cardiac_valve_regurgitation1.37844327
46MP0000427_abnormal_hair_cycle1.37818651
47MP0006035_abnormal_mitochondrial_morpho1.37694102
48MP0000428_abnormal_craniofacial_morphol1.36810332
49MP0003935_abnormal_craniofacial_develop1.35491133
50MP0001730_embryonic_growth_arrest1.33658655
51MP0002938_white_spotting1.32791586
52MP0010352_gastrointestinal_tract_polyps1.32327381
53MP0002166_altered_tumor_susceptibility1.32250817
54MP0006054_spinal_hemorrhage1.32038303
55MP0004272_abnormal_basement_membrane1.31508155
56MP0003755_abnormal_palate_morphology1.31378687
57MP0000372_irregular_coat_pigmentation1.30849677
58MP0002837_dystrophic_cardiac_calcinosis1.30275149
59MP0009250_abnormal_appendicular_skeleto1.28799276
60MP0001929_abnormal_gametogenesis1.28557654
61MP0010678_abnormal_skin_adnexa1.27786872
62MP0002085_abnormal_embryonic_tissue1.26951731
63MP0005257_abnormal_intraocular_pressure1.26582407
64MP0000049_abnormal_middle_ear1.26251923
65MP0003943_abnormal_hepatobiliary_system1.24956518
66MP0002006_tumorigenesis1.24832261
67MP0001188_hyperpigmentation1.24705043
68MP0005174_abnormal_tail_pigmentation1.24666094
69MP0005310_abnormal_salivary_gland1.24565534
70MP0005171_absent_coat_pigmentation1.18974214
71MP0009703_decreased_birth_body1.15985638
72MP0003950_abnormal_plasma_membrane1.14854969
73MP0000778_abnormal_nervous_system1.14722493
74MP0000534_abnormal_ureter_morphology1.14545975
75MP0003221_abnormal_cardiomyocyte_apopto1.13775229
76MP0000350_abnormal_cell_proliferation1.12587060
77MP0000358_abnormal_cell_content/1.12291414
78MP0004215_abnormal_myocardial_fiber1.10468321
79MP0001800_abnormal_humoral_immune1.10048865
80MP0002928_abnormal_bile_duct1.09794343
81MP0002751_abnormal_autonomic_nervous1.09712896
82MP0003890_abnormal_embryonic-extraembry1.08831371
83MP0002132_abnormal_respiratory_system1.07531728
84MP0010386_abnormal_urinary_bladder1.07277093
85MP0003115_abnormal_respiratory_system1.07234683
86MP0001697_abnormal_embryo_size1.06887416
87MP0001545_abnormal_hematopoietic_system1.05777572
88MP0005397_hematopoietic_system_phenotyp1.05777572
89MP0003119_abnormal_digestive_system1.05590466
90MP0000653_abnormal_sex_gland1.04956815
91MP0000733_abnormal_muscle_development1.03383242
92MP0004197_abnormal_fetal_growth/weight/1.03141839
93MP0005623_abnormal_meninges_morphology1.02591563
94MP0000689_abnormal_spleen_morphology1.02289133
95MP0000516_abnormal_urinary_system1.01864183
96MP0005367_renal/urinary_system_phenotyp1.01864183
97MP0004883_abnormal_blood_vessel1.00991268
98MP0003283_abnormal_digestive_organ1.00830092
99MP0003763_abnormal_thymus_physiology1.00708251
100MP0003861_abnormal_nervous_system1.00259634
101MP0001191_abnormal_skin_condition0.99828080
102MP0004133_heterotaxia0.99748923
103MP0002398_abnormal_bone_marrow0.99554564
104MP0002932_abnormal_joint_morphology0.99394403
105MP0004484_altered_response_of0.97251444
106MP0005187_abnormal_penis_morphology0.97146772
107MP0002116_abnormal_craniofacial_bone0.96600622
108MP0002233_abnormal_nose_morphology0.95999730
109MP0003806_abnormal_nucleotide_metabolis0.95522270
110MP0002877_abnormal_melanocyte_morpholog0.95475199
111MP0005508_abnormal_skeleton_morphology0.95291746
112MP0001145_abnormal_male_reproductive0.93910120
113MP0001672_abnormal_embryogenesis/_devel0.93715311
114MP0005380_embryogenesis_phenotype0.93715311
115MP0005395_other_phenotype0.93526898
116MP0003315_abnormal_perineum_morphology0.91966303
117MP0001119_abnormal_female_reproductive0.91963090
118MP0003656_abnormal_erythrocyte_physiolo0.91815207
119MP0006292_abnormal_olfactory_placode0.91322226
120MP0001764_abnormal_homeostasis0.90479969
121MP0000313_abnormal_cell_death0.90467479
122MP0002019_abnormal_tumor_incidence0.89216885
123MP0005389_reproductive_system_phenotype0.88791512
124MP0002282_abnormal_trachea_morphology0.88612530
125MP0006036_abnormal_mitochondrial_physio0.87663876
126MP0003279_aneurysm0.87416475
127MP0009672_abnormal_birth_weight0.87415482
128MP0000003_abnormal_adipose_tissue0.87031455
129MP0010307_abnormal_tumor_latency0.86873965
130MP0002277_abnormal_respiratory_mucosa0.86720320
131MP0005275_abnormal_skin_tensile0.86360144
132MP0002080_prenatal_lethality0.86210021
133MP0002177_abnormal_outer_ear0.86015174
134MP0006072_abnormal_retinal_apoptosis0.85257175
135MP0001270_distended_abdomen0.85177798
136MP0003567_abnormal_fetal_cardiomyocyte0.84851270
137MP0003786_premature_aging0.84751915
138MP0002111_abnormal_tail_morphology0.84355181
139MP0003941_abnormal_skin_development0.84286136
140MP0000647_abnormal_sebaceous_gland0.84135235
141MP0001879_abnormal_lymphatic_vessel0.84069293
142MP0002184_abnormal_innervation0.83787156
143MP0004134_abnormal_chest_morphology0.83140549
144MP0003984_embryonic_growth_retardation0.83127890
145MP0002088_abnormal_embryonic_growth/wei0.81705371
146MP0001293_anophthalmia0.81520334
147MP0002896_abnormal_bone_mineralization0.81347836
148MP0002210_abnormal_sex_determination0.81299379
149MP0002722_abnormal_immune_system0.81145758
150MP0006138_congestive_heart_failure0.80974439
151MP0000703_abnormal_thymus_morphology0.80898267
152MP0003091_abnormal_cell_migration0.80610416
153MP0002102_abnormal_ear_morphology0.80291548
154MP0000631_abnormal_neuroendocrine_gland0.80277595
155MP0002420_abnormal_adaptive_immunity0.80057775
156MP0002108_abnormal_muscle_morphology0.79561616
157MP0002114_abnormal_axial_skeleton0.79321177
158MP0005551_abnormal_eye_electrophysiolog0.78165756
159MP0002086_abnormal_extraembryonic_tissu0.77860900
160MP0000432_abnormal_head_morphology0.77722294
161MP0002452_abnormal_antigen_presenting0.77591950
162MP0002127_abnormal_cardiovascular_syste0.77409159
163MP0002160_abnormal_reproductive_system0.77262567
164MP0005387_immune_system_phenotype0.77094293
165MP0001790_abnormal_immune_system0.77094293
166MP0009278_abnormal_bone_marrow0.76915063
167MP0002723_abnormal_immune_serum0.76836671
168MP0003698_abnormal_male_reproductive0.76561659
169MP0001819_abnormal_immune_cell0.76486502
170MP0001485_abnormal_pinna_reflex0.74938172
171MP0001177_atelectasis0.73483248

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.02527187
2Absent/shortened dynein arms (HP:0200106)4.02527187
3Abnormality of chromosome stability (HP:0003220)3.91868770
4Abnormal respiratory motile cilium morphology (HP:0005938)3.51421806
5Abnormal respiratory epithelium morphology (HP:0012253)3.51421806
6Abnormal ciliary motility (HP:0012262)3.27397888
7Pancreatic fibrosis (HP:0100732)3.27366420
8True hermaphroditism (HP:0010459)3.20112109
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.12207668
10Stenosis of the external auditory canal (HP:0000402)3.06113692
11Abnormal respiratory motile cilium physiology (HP:0012261)2.99822519
12Meckel diverticulum (HP:0002245)2.98995754
13Abnormal hair whorl (HP:0010721)2.96707712
14Pancreatic cysts (HP:0001737)2.93956470
15Absent rod-and cone-mediated responses on ERG (HP:0007688)2.90408996
16Abnormality of the ileum (HP:0001549)2.90267908
17Agnosia (HP:0010524)2.87031210
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.86140070
19Premature rupture of membranes (HP:0001788)2.85468211
20Protrusio acetabuli (HP:0003179)2.81575988
21Abnormality of dentin (HP:0010299)2.73435990
22Clitoromegaly (HP:0000057)2.70557193
23Wrist flexion contracture (HP:0001239)2.68254179
24Abnormality of the preputium (HP:0100587)2.65729538
25Bronchiectasis (HP:0002110)2.62710326
26Nephrogenic diabetes insipidus (HP:0009806)2.60749162
27Duodenal stenosis (HP:0100867)2.60458477
28Small intestinal stenosis (HP:0012848)2.60458477
29Congenital primary aphakia (HP:0007707)2.54831429
30Rhinitis (HP:0012384)2.53528758
31Abnormality of midbrain morphology (HP:0002418)2.53358151
32Molar tooth sign on MRI (HP:0002419)2.53358151
33Sloping forehead (HP:0000340)2.52269866
34Nephronophthisis (HP:0000090)2.51514073
35Abnormality of the astrocytes (HP:0100707)2.51358117
36Astrocytoma (HP:0009592)2.51358117
37Ankle contracture (HP:0006466)2.47128879
38Clubbing of toes (HP:0100760)2.45569446
39Shallow orbits (HP:0000586)2.44305828
40Abnormality of the duodenum (HP:0002246)2.42259144
41Shoulder girdle muscle weakness (HP:0003547)2.42199802
42Acute lymphatic leukemia (HP:0006721)2.41932898
43Chronic bronchitis (HP:0004469)2.37877279
44Menstrual irregularities (HP:0000858)2.35158449
45Gait imbalance (HP:0002141)2.35121251
46Intestinal atresia (HP:0011100)2.33099627
47Mesomelia (HP:0003027)2.32843775
48Buphthalmos (HP:0000557)2.32421851
49Ependymoma (HP:0002888)2.27436371
50Bowel diverticulosis (HP:0005222)2.26491928
51Rectal fistula (HP:0100590)2.24854981
52Rectovaginal fistula (HP:0000143)2.24854981
53Chronic otitis media (HP:0000389)2.23940692
54Abnormality of the renal medulla (HP:0100957)2.23018305
55Bladder diverticulum (HP:0000015)2.21522675
56Orthostatic hypotension (HP:0001278)2.20880866
57Soft skin (HP:0000977)2.20650888
58Tubulointerstitial nephritis (HP:0001970)2.20243135
59Supernumerary spleens (HP:0009799)2.20022980
60Biliary tract neoplasm (HP:0100574)2.19369441
61Neoplasm of striated muscle (HP:0009728)2.12769650
62Spinal rigidity (HP:0003306)2.10282487
63Genital tract atresia (HP:0001827)2.09461215
64Postaxial foot polydactyly (HP:0001830)2.08702472
65Rhabdomyosarcoma (HP:0002859)2.08520224
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.07735252
67Abnormality of the renal cortex (HP:0011035)2.06564355
68Renal duplication (HP:0000075)2.06100204
69Genu recurvatum (HP:0002816)2.05142570
70Cervical subluxation (HP:0003308)2.04739097
71Acute myeloid leukemia (HP:0004808)2.04623610
72Astigmatism (HP:0000483)2.03570967
73Pelvic girdle muscle weakness (HP:0003749)2.03320632
74Abnormality of the labia minora (HP:0012880)2.03250732
75Myelodysplasia (HP:0002863)2.02996378
76Fair hair (HP:0002286)2.02930529
77Vaginal atresia (HP:0000148)2.02589960
78Papillary thyroid carcinoma (HP:0002895)2.01920341
79Poor coordination (HP:0002370)2.00649057
80Abnormal rod and cone electroretinograms (HP:0008323)2.00260447
81Gonadotropin excess (HP:0000837)2.00108786
82Abnormal biliary tract physiology (HP:0012439)1.98718107
83Bile duct proliferation (HP:0001408)1.98718107
84Abnormality of the carotid arteries (HP:0005344)1.98482302
85Medulloblastoma (HP:0002885)1.97962374
86Stomach cancer (HP:0012126)1.96727345
87Spinal muscular atrophy (HP:0007269)1.96224190
88Chronic hepatic failure (HP:0100626)1.95763536
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93708653
90Short 4th metacarpal (HP:0010044)1.93708653
91Renal cortical cysts (HP:0000803)1.92625658
92Facial cleft (HP:0002006)1.92298697
93Abnormality of the hip-girdle musculature (HP:0001445)1.91526975
94Abnormality of the musculature of the pelvis (HP:0001469)1.91526975
95Glioma (HP:0009733)1.89443981
96Abnormality of T cell number (HP:0011839)1.88448737
97Selective tooth agenesis (HP:0001592)1.86990508
98Recurrent bacterial skin infections (HP:0005406)1.86972305
99Nephroblastoma (Wilms tumor) (HP:0002667)1.86661874
100Broad foot (HP:0001769)1.85232458
101Cafe-au-lait spot (HP:0000957)1.84691065
102Rimmed vacuoles (HP:0003805)1.84673754
103Increased nuchal translucency (HP:0010880)1.84644692
104Colon cancer (HP:0003003)1.84619380
105Embryonal renal neoplasm (HP:0011794)1.83594632
106T lymphocytopenia (HP:0005403)1.82334522
107IgM deficiency (HP:0002850)1.82235571
108Panhypogammaglobulinemia (HP:0003139)1.81968833
109Abnormality of DNA repair (HP:0003254)1.81959585
110Ectopic kidney (HP:0000086)1.80508888
111Abnormality of the clitoris (HP:0000056)1.80345653
112Abnormality of the anterior horn cell (HP:0006802)1.80230397
113Degeneration of anterior horn cells (HP:0002398)1.80230397
114Abnormality of B cell number (HP:0010975)1.80063444
115Anencephaly (HP:0002323)1.79371336
116Congenital hepatic fibrosis (HP:0002612)1.78732930
117Progressive inability to walk (HP:0002505)1.78700556
118Oligodactyly (hands) (HP:0001180)1.78277867
119Hyperglycinemia (HP:0002154)1.78201389
120Microvesicular hepatic steatosis (HP:0001414)1.78157511
121Volvulus (HP:0002580)1.77842562
122Congenital glaucoma (HP:0001087)1.77797345
123Neoplasm of the small intestine (HP:0100833)1.76274295
124Freckling (HP:0001480)1.75961365
125Broad long bones (HP:0005622)1.75522132
126Oculomotor apraxia (HP:0000657)1.75518946
127Wormian bones (HP:0002645)1.73982636
128Deviation of the thumb (HP:0009603)1.73919535
129High anterior hairline (HP:0009890)1.72686962
130Mild short stature (HP:0003502)1.72203795
131Chromsome breakage (HP:0040012)1.71956029
132Hepatoblastoma (HP:0002884)1.70336393
133Anterior segment dysgenesis (HP:0007700)1.68890614
134Spinal cord lesions (HP:0100561)1.67971874
135Syringomyelia (HP:0003396)1.67971874
136Patellar aplasia (HP:0006443)1.67810033
137Broad phalanx (HP:0006009)1.67454506
138Overgrowth (HP:0001548)1.66686583
139Broad thumb (HP:0011304)1.66590742
140Renovascular hypertension (HP:0100817)1.66060394
141Slender long bone (HP:0003100)1.65647439
142Broad finger (HP:0001500)1.65034682
143Aortic aneurysm (HP:0004942)1.64630897
144Birth length less than 3rd percentile (HP:0003561)1.62515279
145Broad phalanges of the hand (HP:0009768)1.61884574
146Broad palm (HP:0001169)1.61809240
147Neonatal short-limb short stature (HP:0008921)1.60803019
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.59732128
149Atrophy/Degeneration involving motor neurons (HP:0007373)1.58594308
150Limb-girdle muscle weakness (HP:0003325)1.57887937
151Aortic dissection (HP:0002647)1.56985157
152Abnormality of the calcaneus (HP:0008364)1.56934070
153Cerebral hypomyelination (HP:0006808)1.56733288
154Subacute progressive viral hepatitis (HP:0006572)1.55465368
155Abnormal lung lobation (HP:0002101)1.55169952
156Aplasia/Hypoplasia of the patella (HP:0006498)1.55134584
157Cerebral aneurysm (HP:0004944)1.54538020
158Proximal placement of thumb (HP:0009623)1.54445801
159Chromosomal breakage induced by crosslinking agents (HP:0003221)1.53209694
160Shawl scrotum (HP:0000049)1.52507448
161Broad metatarsal (HP:0001783)1.50897054
162Abnormality of the 4th metacarpal (HP:0010012)1.49947183
163Broad face (HP:0000283)1.49589549
164Neoplasm of the adrenal cortex (HP:0100641)1.48009300
165Microglossia (HP:0000171)1.47773786
166Neoplasm of the peripheral nervous system (HP:0100007)1.47650250
167Capillary hemangiomas (HP:0005306)1.47486527
168Intestinal polyposis (HP:0200008)1.47131337
169Abnormality of the fetal cardiovascular system (HP:0010948)1.47090990
170Abnormal umbilical cord blood vessels (HP:0011403)1.47090990
171Single umbilical artery (HP:0001195)1.47090990
172Medial flaring of the eyebrow (HP:0010747)1.46385601
173Short clavicles (HP:0000894)1.43715869
174Ankle clonus (HP:0011448)1.43037687
175Neoplasm of the adrenal gland (HP:0100631)1.42313030
176Abnormality of the aortic arch (HP:0012303)1.41910972
177Abnormality of the metopic suture (HP:0005556)1.41753465
178Joint laxity (HP:0001388)1.41357924
179Pointed chin (HP:0000307)1.41200994
180Thyroid carcinoma (HP:0002890)1.39280042
181Abnormal pancreas size (HP:0012094)1.38120763
182Short foot (HP:0001773)1.37718826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB33.15615432
2BUB12.81198721
3NUAK12.68282632
4SRPK12.51483188
5TSSK62.40907175
6ACVR1B2.34430260
7CDC72.33552894
8CASK2.24918502
9LIMK12.24246803
10MAP4K22.14799386
11TAOK32.07051517
12PLK32.01533601
13PASK1.98070835
14MST41.96973714
15MKNK11.96351526
16PBK1.93664021
17PIK3CG1.92261084
18TNIK1.91562685
19WEE11.85241136
20PLK21.82119412
21CCNB11.78839990
22NEK11.78599341
23CDK121.74846488
24LATS21.74471362
25TRIM281.70678914
26STK38L1.55705226
27TESK11.52182489
28DDR21.50540842
29* PLK11.48583179
30MKNK21.48426587
31TEC1.46699648
32MAP3K81.45151701
33PDGFRA1.44653501
34TGFBR11.43942099
35NLK1.42641248
36TTK1.39965025
37TLK11.36218682
38ZAK1.34175367
39AKT31.30034140
40BCKDK1.29074417
41PLK41.22859736
42VRK11.22499201
43MARK11.19989975
44TXK1.17516995
45ATR1.16779840
46IRAK11.14167405
47SIK31.13826187
48PKN21.13172345
49CDK81.12519979
50EIF2AK11.10875281
51BRSK21.10563281
52MINK11.10320083
53FGFR11.09214827
54NEK91.06783648
55FLT31.06420899
56SCYL21.05450016
57WNK31.05012810
58MAP4K11.04609626
59TTN1.01535394
60CHEK20.99306367
61KSR10.98871420
62NEK20.98259062
63BCR0.98070522
64PAK30.97229764
65EIF2AK20.95538228
66PTK60.95131968
67CSNK1A1L0.92172522
68TAF10.91984703
69FER0.91321284
70AURKA0.89749554
71BMPR20.89687105
72TRIB30.87279733
73CSNK1G10.86179572
74AURKB0.85895985
75CAMK1G0.84583869
76EPHB20.84582827
77STK240.83872205
78BRSK10.83246944
79FRK0.83233681
80YES10.81274045
81ATM0.79606187
82CHEK10.78755445
83EPHA30.78344419
84TAOK20.76688531
85CSNK1G30.76641428
86CDK60.76313431
87MAP3K40.76237868
88PAK40.75622316
89BRD40.75587034
90PNCK0.74555735
91LATS10.72144317
92DYRK20.71586930
93CAMK1D0.68129785
94BMPR1B0.67331991
95NTRK30.67114165
96MET0.66911821
97MARK30.65363032
98SGK20.65287162
99MAPK130.63076789
100ROCK10.62214337
101OXSR10.61985539
102ILK0.61927248
103* CDK10.61257396
104ITK0.60583633
105TESK20.58679396
106CDK70.58661180
107MAP3K50.56819118
108EEF2K0.54764972
109BTK0.54705332
110GRK10.53600061
111CSNK1G20.53536416
112STK30.53443145
113DYRK30.53414113
114STK100.51954623
115CDK140.51823814
116ROCK20.51458658
117MAP3K100.50745594
118MUSK0.50320767
119PDK20.49048848
120ADRBK20.48340153
121MAP3K140.47795819
122MAPKAPK30.47558497
123MELK0.46913488
124NME10.46208975
125BRAF0.45036616
126CDK20.44453961
127EIF2AK30.44136672
128CSNK1E0.43993857
129UHMK10.43889365
130CDK190.43640707
131RET0.43396262
132PRKD30.42956062
133CDK30.42811534
134ALK0.42656010
135CDK40.41803054
136PDK40.41789788
137PDK30.41789788
138RPS6KA40.41371989
139NEK60.40330631
140TYK20.40112210
141IKBKE0.39440068
142MAP3K120.38473248
143PRKCQ0.37026481
144EGFR0.36708640
145VRK20.36412511
146FES0.35284728
147FGFR20.32025374
148CSNK2A20.30847103
149IKBKB0.30432746
150SYK0.30154684
151LYN0.28726371
152CSNK2A10.28638436

Predicted pathways (KEGG)

RankGene SetZ-score
1* Cell cycle_Homo sapiens_hsa041102.45772476
2Mismatch repair_Homo sapiens_hsa034302.41906238
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22407234
4RNA transport_Homo sapiens_hsa030132.15834235
5Propanoate metabolism_Homo sapiens_hsa006402.07909009
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03493227
7RNA polymerase_Homo sapiens_hsa030202.02524054
8Nucleotide excision repair_Homo sapiens_hsa034201.96431248
9DNA replication_Homo sapiens_hsa030301.95639067
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.92348986
11Selenocompound metabolism_Homo sapiens_hsa004501.89530169
12Spliceosome_Homo sapiens_hsa030401.88969985
13mRNA surveillance pathway_Homo sapiens_hsa030151.82742511
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82389524
15Proteasome_Homo sapiens_hsa030501.73349149
16* Oocyte meiosis_Homo sapiens_hsa041141.66335871
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62947173
18* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.60142296
19Fanconi anemia pathway_Homo sapiens_hsa034601.56929505
20* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49466330
21Basal transcription factors_Homo sapiens_hsa030221.47742461
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46122539
23Hippo signaling pathway_Homo sapiens_hsa043901.43139275
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.36285782
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34959406
26Epstein-Barr virus infection_Homo sapiens_hsa051691.33571947
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32882698
28Primary immunodeficiency_Homo sapiens_hsa053401.32355418
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30605778
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29586336
31Colorectal cancer_Homo sapiens_hsa052101.28635911
32Protein export_Homo sapiens_hsa030601.24800018
33Base excision repair_Homo sapiens_hsa034101.21064159
34Basal cell carcinoma_Homo sapiens_hsa052171.19295456
35Non-homologous end-joining_Homo sapiens_hsa034501.18291935
36Focal adhesion_Homo sapiens_hsa045101.17871374
37N-Glycan biosynthesis_Homo sapiens_hsa005101.16090199
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13020898
39Butanoate metabolism_Homo sapiens_hsa006501.11805157
40Endometrial cancer_Homo sapiens_hsa052131.11571553
41Alcoholism_Homo sapiens_hsa050341.09268020
42MicroRNAs in cancer_Homo sapiens_hsa052061.07888211
43Viral carcinogenesis_Homo sapiens_hsa052031.06123925
44p53 signaling pathway_Homo sapiens_hsa041151.06094839
45* HTLV-I infection_Homo sapiens_hsa051661.05764070
46Hedgehog signaling pathway_Homo sapiens_hsa043401.05269723
47Adherens junction_Homo sapiens_hsa045201.04750165
48Homologous recombination_Homo sapiens_hsa034401.03308886
49Herpes simplex infection_Homo sapiens_hsa051681.01711046
50RNA degradation_Homo sapiens_hsa030181.01567765
51Proteoglycans in cancer_Homo sapiens_hsa052051.01216644
52Vibrio cholerae infection_Homo sapiens_hsa051101.00727596
53Ether lipid metabolism_Homo sapiens_hsa005651.00714229
54Prostate cancer_Homo sapiens_hsa052151.00483424
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98022536
56ECM-receptor interaction_Homo sapiens_hsa045120.97332248
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96966114
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96075527
59Legionellosis_Homo sapiens_hsa051340.94463383
60Pyrimidine metabolism_Homo sapiens_hsa002400.94026927
61Wnt signaling pathway_Homo sapiens_hsa043100.94005384
62Axon guidance_Homo sapiens_hsa043600.93692872
63TGF-beta signaling pathway_Homo sapiens_hsa043500.93669123
64Small cell lung cancer_Homo sapiens_hsa052220.93066253
65Glioma_Homo sapiens_hsa052140.92862983
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92646728
67Melanoma_Homo sapiens_hsa052180.92487679
68mTOR signaling pathway_Homo sapiens_hsa041500.91100364
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90475300
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87512428
71Renal cell carcinoma_Homo sapiens_hsa052110.87409198
72Circadian rhythm_Homo sapiens_hsa047100.86911424
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81827049
74Pancreatic cancer_Homo sapiens_hsa052120.81732901
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81211801
76Thyroid cancer_Homo sapiens_hsa052160.81117790
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80107180
78Tight junction_Homo sapiens_hsa045300.80026289
79Glutathione metabolism_Homo sapiens_hsa004800.77880625
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.77708609
81One carbon pool by folate_Homo sapiens_hsa006700.75811557
82Chronic myeloid leukemia_Homo sapiens_hsa052200.75676650
83Purine metabolism_Homo sapiens_hsa002300.75578725
84Antigen processing and presentation_Homo sapiens_hsa046120.74832790
85Steroid biosynthesis_Homo sapiens_hsa001000.73365647
86Dilated cardiomyopathy_Homo sapiens_hsa054140.73312153
87Gap junction_Homo sapiens_hsa045400.73297838
88Pathways in cancer_Homo sapiens_hsa052000.72841890
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72317198
90Peroxisome_Homo sapiens_hsa041460.71758692
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70329025
92Regulation of autophagy_Homo sapiens_hsa041400.70217793
93Lysine degradation_Homo sapiens_hsa003100.68391754
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67562473
95Linoleic acid metabolism_Homo sapiens_hsa005910.66468145
96Dopaminergic synapse_Homo sapiens_hsa047280.66251007
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.65972200
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65940693
99Measles_Homo sapiens_hsa051620.64861127
100Viral myocarditis_Homo sapiens_hsa054160.64085950
101Melanogenesis_Homo sapiens_hsa049160.64004172
102Non-small cell lung cancer_Homo sapiens_hsa052230.63194289
103Systemic lupus erythematosus_Homo sapiens_hsa053220.62710165
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.61317935
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61002622
106ErbB signaling pathway_Homo sapiens_hsa040120.60629676
107FoxO signaling pathway_Homo sapiens_hsa040680.60458164
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60458145
109Bladder cancer_Homo sapiens_hsa052190.59542746
110Estrogen signaling pathway_Homo sapiens_hsa049150.58903698
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58897293
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57432487
113Phototransduction_Homo sapiens_hsa047440.57432425
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56903256
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56346938
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55919626
117Caffeine metabolism_Homo sapiens_hsa002320.55708043
118Insulin signaling pathway_Homo sapiens_hsa049100.52305081
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52117454
120Phagosome_Homo sapiens_hsa041450.52006223
121Rap1 signaling pathway_Homo sapiens_hsa040150.51632476
122Endocytosis_Homo sapiens_hsa041440.50772414
123Olfactory transduction_Homo sapiens_hsa047400.50027814
124Type I diabetes mellitus_Homo sapiens_hsa049400.47149808
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46088357
126Synaptic vesicle cycle_Homo sapiens_hsa047210.45619155
127Fatty acid degradation_Homo sapiens_hsa000710.45615620
128Shigellosis_Homo sapiens_hsa051310.45013291
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44874172
130Cocaine addiction_Homo sapiens_hsa050300.44390244
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44226962
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43685913
133Inositol phosphate metabolism_Homo sapiens_hsa005620.43256127
134Graft-versus-host disease_Homo sapiens_hsa053320.42992151
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42589983
136Huntingtons disease_Homo sapiens_hsa050160.41188320
137AMPK signaling pathway_Homo sapiens_hsa041520.40807185
138Amphetamine addiction_Homo sapiens_hsa050310.40792919
139Chemical carcinogenesis_Homo sapiens_hsa052040.40245521
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.37720577
141Allograft rejection_Homo sapiens_hsa053300.33930204
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33706986
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33329942
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32886467
145Glycerolipid metabolism_Homo sapiens_hsa005610.31938751
146NF-kappa B signaling pathway_Homo sapiens_hsa040640.31655385
147Hematopoietic cell lineage_Homo sapiens_hsa046400.30878115
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28646760
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.28475619
150Autoimmune thyroid disease_Homo sapiens_hsa053200.28156928
151Hepatitis B_Homo sapiens_hsa051610.27942673
152Nitrogen metabolism_Homo sapiens_hsa009100.27771603
153Dorso-ventral axis formation_Homo sapiens_hsa043200.26708275
154Influenza A_Homo sapiens_hsa051640.26288531
155beta-Alanine metabolism_Homo sapiens_hsa004100.25863212
156Tryptophan metabolism_Homo sapiens_hsa003800.25803107
157T cell receptor signaling pathway_Homo sapiens_hsa046600.25720241
158Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25535211
159Metabolic pathways_Homo sapiens_hsa011000.25195578
160Staphylococcus aureus infection_Homo sapiens_hsa051500.23660705
161Taste transduction_Homo sapiens_hsa047420.22717042
162Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22147147
163Drug metabolism - other enzymes_Homo sapiens_hsa009830.21165724
164Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20687659
165Sphingolipid metabolism_Homo sapiens_hsa006000.20035696
166Retinol metabolism_Homo sapiens_hsa008300.18994507
167Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18645162

Most similar genes based on co-expression Upload to Enrichr

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