ANAPC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.56113877
2DNA strand elongation involved in DNA replication (GO:0006271)4.80970976
3DNA strand elongation (GO:0022616)4.56425709
4protein localization to kinetochore (GO:0034501)4.36163461
5mitotic chromosome condensation (GO:0007076)4.28998281
6protein localization to chromosome, centromeric region (GO:0071459)4.20699561
7negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.09191226
8telomere maintenance via semi-conservative replication (GO:0032201)3.98107853
9peptidyl-histidine modification (GO:0018202)3.94457215
10pseudouridine synthesis (GO:0001522)3.90895070
11ribosomal small subunit assembly (GO:0000028)3.81805879
12negative regulation of RNA splicing (GO:0033119)3.80773918
13somatic diversification of immune receptors via somatic mutation (GO:0002566)3.77929303
14somatic hypermutation of immunoglobulin genes (GO:0016446)3.77929303
15DNA replication initiation (GO:0006270)3.77631205
16mitotic sister chromatid cohesion (GO:0007064)3.76534587
17sister chromatid segregation (GO:0000819)3.73975797
18proteasome assembly (GO:0043248)3.72287541
19mitotic nuclear envelope disassembly (GO:0007077)3.71278908
20meiotic chromosome segregation (GO:0045132)3.68166731
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62748407
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.61576763
23nuclear pore organization (GO:0006999)3.61011250
24DNA replication-dependent nucleosome assembly (GO:0006335)3.59796151
25DNA replication-dependent nucleosome organization (GO:0034723)3.59796151
26translesion synthesis (GO:0019985)3.58558901
273-UTR-mediated mRNA stabilization (GO:0070935)3.56431932
28DNA duplex unwinding (GO:0032508)3.56295305
29nuclear envelope disassembly (GO:0051081)3.56114838
30membrane disassembly (GO:0030397)3.56114838
31attachment of spindle microtubules to kinetochore (GO:0008608)3.55801514
32mitochondrial RNA metabolic process (GO:0000959)3.55580646
33IMP biosynthetic process (GO:0006188)3.54698360
34DNA geometric change (GO:0032392)3.53454910
35mitotic sister chromatid segregation (GO:0000070)3.53319585
36regulation of sister chromatid cohesion (GO:0007063)3.52292100
37rRNA modification (GO:0000154)3.49455818
38viral transcription (GO:0019083)3.48965188
39mitotic recombination (GO:0006312)3.48113051
40maturation of SSU-rRNA (GO:0030490)3.44362942
41peptidyl-arginine omega-N-methylation (GO:0035247)3.43168626
42telomere maintenance via recombination (GO:0000722)3.41910711
43mitotic metaphase plate congression (GO:0007080)3.41415316
44replication fork processing (GO:0031297)3.41358108
45translational termination (GO:0006415)3.40708090
46negative regulation of mRNA processing (GO:0050686)3.38185937
47dosage compensation (GO:0007549)3.35492165
48formation of translation preinitiation complex (GO:0001731)3.34146748
49viral mRNA export from host cell nucleus (GO:0046784)3.33106485
50ribosome assembly (GO:0042255)3.31875300
51peptidyl-lysine dimethylation (GO:0018027)3.31513321
52amino acid activation (GO:0043038)3.27564532
53tRNA aminoacylation (GO:0043039)3.27564532
54translational elongation (GO:0006414)3.26373624
55nuclear pore complex assembly (GO:0051292)3.26069503
56tRNA aminoacylation for protein translation (GO:0006418)3.25091241
57IMP metabolic process (GO:0046040)3.25049046
58double-strand break repair via nonhomologous end joining (GO:0006303)3.24577192
59non-recombinational repair (GO:0000726)3.24577192
60DNA topological change (GO:0006265)3.24334216
61folic acid-containing compound biosynthetic process (GO:0009396)3.24154303
62telomere maintenance via telomere lengthening (GO:0010833)3.21276343
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.18772140
64COPI coating of Golgi vesicle (GO:0048205)3.17655492
65Golgi transport vesicle coating (GO:0048200)3.17655492
66regulation of translational fidelity (GO:0006450)3.17296735
67DNA replication checkpoint (GO:0000076)3.15392586
68deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14390254
69postreplication repair (GO:0006301)3.14007979
70protein localization to chromosome (GO:0034502)3.13788241
71translational initiation (GO:0006413)3.11232321
72regulation of spindle organization (GO:0090224)3.11141191
73negative regulation of mRNA metabolic process (GO:1903312)3.10017720
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09885913
75mRNA stabilization (GO:0048255)3.08528329
76RNA stabilization (GO:0043489)3.08528329
77GMP metabolic process (GO:0046037)3.07663878
78ribosome biogenesis (GO:0042254)3.07460664
79peptidyl-arginine N-methylation (GO:0035246)3.06053995
80peptidyl-arginine methylation (GO:0018216)3.06053995
81nuclear envelope organization (GO:0006998)3.06048852
82positive regulation of chromosome segregation (GO:0051984)3.04764023
83maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02990290
84* regulation of chromosome segregation (GO:0051983)3.01698014
85negative regulation of histone methylation (GO:0031061)3.01220046
86regulation of mitochondrial translation (GO:0070129)3.00941300
87pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.00626503
88valine metabolic process (GO:0006573)3.00205962
89metaphase plate congression (GO:0051310)3.00090308
90maturation of 5.8S rRNA (GO:0000460)2.99520267
91DNA conformation change (GO:0071103)2.98061722
92L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96914965
93regulation of translational termination (GO:0006449)2.95953573
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95463948
95chromosome condensation (GO:0030261)2.93929310
96rRNA methylation (GO:0031167)2.93561123
97mismatch repair (GO:0006298)2.92983101
98regulation of DNA damage checkpoint (GO:2000001)2.92934231
99establishment of chromosome localization (GO:0051303)2.92760345
100DNA replication-independent nucleosome assembly (GO:0006336)2.92281450
101DNA replication-independent nucleosome organization (GO:0034724)2.92281450
102RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91872699
103histone H2A acetylation (GO:0043968)2.91296215
104regulation of histone H3-K9 methylation (GO:0051570)2.90798450
105mitotic G1 DNA damage checkpoint (GO:0031571)2.89958627
106chromatin assembly or disassembly (GO:0006333)2.89382247
107DNA ligation (GO:0006266)2.88917383
108ATP-dependent chromatin remodeling (GO:0043044)2.87907660
109* spindle assembly checkpoint (GO:0071173)2.87601777
110base-excision repair (GO:0006284)2.87463028
111branched-chain amino acid catabolic process (GO:0009083)2.86685374
112RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.85872010
113mRNA splicing, via spliceosome (GO:0000398)2.85872010
114SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85779130
115ubiquinone biosynthetic process (GO:0006744)2.85667367
116tRNA metabolic process (GO:0006399)2.84958767
117* mitotic spindle assembly checkpoint (GO:0007094)2.84416029
118alternative mRNA splicing, via spliceosome (GO:0000380)2.83539021
119pyrimidine nucleotide catabolic process (GO:0006244)2.83281928
120positive regulation of mitotic sister chromatid separation (GO:1901970)2.82873056
121positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82873056
122positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82873056
123heterochromatin organization (GO:0070828)2.82374128
124* negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81636785
125RNA splicing, via transesterification reactions (GO:0000375)2.80909152
126* negative regulation of chromosome segregation (GO:0051985)2.80463863
127nucleobase biosynthetic process (GO:0046112)2.80454687
128pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.79956636
129protein complex disassembly (GO:0043241)2.79467335
130synapsis (GO:0007129)2.79318423
131pore complex assembly (GO:0046931)2.79163138
132cellular protein complex disassembly (GO:0043624)2.78687130
133* negative regulation of mitotic sister chromatid separation (GO:2000816)2.78557208
134* negative regulation of mitotic sister chromatid segregation (GO:0033048)2.78557208
135* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.78557208
136* negative regulation of sister chromatid segregation (GO:0033046)2.78557208
137oxidative phosphorylation (GO:0006119)2.78211177
138purine nucleobase biosynthetic process (GO:0009113)2.78040203
139chromatin remodeling at centromere (GO:0031055)2.77610484
140branched-chain amino acid metabolic process (GO:0009081)2.77597759
141proline biosynthetic process (GO:0006561)2.76442661
142protein targeting to ER (GO:0045047)2.75867260
143DNA-dependent DNA replication (GO:0006261)2.74354489
144telomere maintenance (GO:0000723)2.72518267
145kinetochore organization (GO:0051383)2.71493760
146guanosine-containing compound biosynthetic process (GO:1901070)2.70634729
147methionine biosynthetic process (GO:0009086)2.69785913
148* positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69571579
149telomere organization (GO:0032200)2.69529600
150tRNA modification (GO:0006400)2.69180194
151metallo-sulfur cluster assembly (GO:0031163)2.67902522
152iron-sulfur cluster assembly (GO:0016226)2.67902522
153tRNA processing (GO:0008033)2.67807728
154base-excision repair, AP site formation (GO:0006285)2.67655989
155ribosomal large subunit biogenesis (GO:0042273)2.67600779
156signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67499488
157signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67499488
158signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67499488
159tRNA methylation (GO:0030488)2.67400277
160* regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67217026
161pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.67095680
162transcription-coupled nucleotide-excision repair (GO:0006283)2.66645540
163pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.66234090
164protein deneddylation (GO:0000338)2.63487489
165ribonucleoprotein complex biogenesis (GO:0022613)2.62488341
166rRNA processing (GO:0006364)2.62178869
167signal transduction involved in DNA damage checkpoint (GO:0072422)2.61403516
168signal transduction involved in DNA integrity checkpoint (GO:0072401)2.61403516
169pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.61055999
170intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.60754959
171signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.60754959
172* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60500558

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.65961558
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.27494234
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89639898
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.68348320
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40522825
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97394409
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.96076988
8MYC_22102868_ChIP-Seq_BL_Human2.86163823
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84540742
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72804105
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.49418240
12XRN2_22483619_ChIP-Seq_HELA_Human2.37417751
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35806925
14CIITA_25753668_ChIP-Seq_RAJI_Human2.35599462
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32111770
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20819041
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16416080
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.08525818
19* ETS1_20019798_ChIP-Seq_JURKAT_Human2.07528411
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02668040
21AR_21909140_ChIP-Seq_LNCAP_Human1.99762929
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94199392
23* VDR_21846776_ChIP-Seq_THP-1_Human1.93914089
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83018091
25* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82990468
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77493769
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76647460
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76500106
29* EST1_17652178_ChIP-ChIP_JURKAT_Human1.74890428
30* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74221990
31* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73326554
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67177161
33ZNF263_19887448_ChIP-Seq_K562_Human1.63907828
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.63681998
35GABP_19822575_ChIP-Seq_HepG2_Human1.63081018
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63013234
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62135743
38TTF2_22483619_ChIP-Seq_HELA_Human1.62014822
39* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61395735
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.61085934
41KDM5A_27292631_Chip-Seq_BREAST_Human1.60867469
42* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60417303
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59463051
44* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59109478
45GATA1_22025678_ChIP-Seq_K562_Human1.58452787
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53571973
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52421698
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52384891
49* FOXP3_21729870_ChIP-Seq_TREG_Human1.51706763
50VDR_23849224_ChIP-Seq_CD4+_Human1.50936613
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49456933
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47633698
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47434733
54DCP1A_22483619_ChIP-Seq_HELA_Human1.46842156
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43412634
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42601944
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42276486
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35493277
59MYC_18940864_ChIP-ChIP_HL60_Human1.34648341
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33887880
61* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33373848
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31934167
63TCF7_22412390_ChIP-Seq_EML_Mouse1.29140731
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27177846
65* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25920430
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25792636
67* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25324392
68TFEB_21752829_ChIP-Seq_HELA_Human1.25032644
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.22948186
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22677038
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22204212
72KDM2B_26808549_Chip-Seq_DND41_Human1.21319771
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20851845
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20562488
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.20349320
76* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19836332
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18943606
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17592220
79IRF1_19129219_ChIP-ChIP_H3396_Human1.16882717
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15831038
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14546969
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14068178
83* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12707554
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11095109
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10874727
86ZNF274_21170338_ChIP-Seq_K562_Hela1.10624197
87UTX_26944678_Chip-Seq_JUKART_Human1.09369958
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08846845
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.08746977
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08697379
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07397246
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06898630
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06585149
94* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06584097
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06478535
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05782029
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04311641
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02812628
99* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01930394
100* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01414821
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00427744
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99302598
103CHD1_26751641_Chip-Seq_LNCaP_Human0.98580740
104MAF_26560356_Chip-Seq_TH1_Human0.96483019
105SCL_19346495_ChIP-Seq_HPC-7_Human0.95700783
106ELK1_19687146_ChIP-ChIP_HELA_Human0.95348819
107YY1_21170310_ChIP-Seq_MESCs_Mouse0.94748916
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94040347
109ATF3_27146783_Chip-Seq_COLON_Human0.91737917
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91159146
111NOTCH1_21737748_ChIP-Seq_TLL_Human0.91045711
112MYB_26560356_Chip-Seq_TH2_Human0.90392886
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89544810
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89532738
115CLOCK_20551151_ChIP-Seq_293T_Human0.88836246
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87854075
117LXR_22292898_ChIP-Seq_THP-1_Human0.87289670
118FOXP1_21924763_ChIP-Seq_HESCs_Human0.86750026
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86505980
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86376927
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84807085
122MYB_26560356_Chip-Seq_TH1_Human0.84200850
123SALL1_21062744_ChIP-ChIP_HESCs_Human0.83408132
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83160771
125* SPI1_23547873_ChIP-Seq_NB4_Human0.82315441
126RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80881538
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78808670
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75956113
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74467736
130HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73609724
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71538436
132HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69890638
133PKCTHETA_26484144_Chip-Seq_BREAST_Human0.68189742
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.67336102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.75301693
2MP0004147_increased_porphyrin_level3.60397591
3MP0003111_abnormal_nucleus_morphology3.57594457
4MP0003693_abnormal_embryo_hatching3.50713346
5MP0003077_abnormal_cell_cycle3.18464785
6MP0004957_abnormal_blastocyst_morpholog3.17253112
7MP0003123_paternal_imprinting2.51985171
8MP0006036_abnormal_mitochondrial_physio2.35263803
9MP0001661_extended_life_span2.33103409
10MP0006035_abnormal_mitochondrial_morpho2.27349061
11MP0003718_maternal_effect2.25890826
12MP0001730_embryonic_growth_arrest2.25707267
13MP0008007_abnormal_cellular_replicative2.20103770
14MP0003221_abnormal_cardiomyocyte_apopto2.15474617
15MP0003763_abnormal_thymus_physiology2.14960661
16MP0010352_gastrointestinal_tract_polyps2.13482458
17MP0009697_abnormal_copulation2.09889550
18MP0003705_abnormal_hypodermis_morpholog2.08624713
19MP0005075_abnormal_melanosome_morpholog2.08458212
20MP0000537_abnormal_urethra_morphology2.06723513
21MP0000350_abnormal_cell_proliferation1.97728344
22MP0000372_irregular_coat_pigmentation1.95712581
23MP0005464_abnormal_platelet_physiology1.95221943
24MP0002877_abnormal_melanocyte_morpholog1.95123320
25MP0000751_myopathy1.93728979
26MP0002396_abnormal_hematopoietic_system1.92285435
27MP0005076_abnormal_cell_differentiation1.91233722
28MP0001873_stomach_inflammation1.89663695
29MP0004808_abnormal_hematopoietic_stem1.89141635
30MP0003121_genomic_imprinting1.87083222
31MP0010307_abnormal_tumor_latency1.87041046
32MP0008932_abnormal_embryonic_tissue1.83820921
33MP0008057_abnormal_DNA_replication1.80664924
34MP0006054_spinal_hemorrhage1.78426679
35MP0003806_abnormal_nucleotide_metabolis1.77390842
36MP0004197_abnormal_fetal_growth/weight/1.71416042
37MP0001697_abnormal_embryo_size1.70002219
38MP0010030_abnormal_orbit_morphology1.66921795
39MP0008058_abnormal_DNA_repair1.65813585
40MP0002080_prenatal_lethality1.63188105
41MP0003315_abnormal_perineum_morphology1.63099738
42MP0008877_abnormal_DNA_methylation1.62596955
43MP0003283_abnormal_digestive_organ1.60159390
44MP0000733_abnormal_muscle_development1.59295207
45MP0001672_abnormal_embryogenesis/_devel1.58199102
46MP0005380_embryogenesis_phenotype1.58199102
47MP0002084_abnormal_developmental_patter1.58081766
48MP0004233_abnormal_muscle_weight1.56717814
49MP0002085_abnormal_embryonic_tissue1.55727132
50MP0003567_abnormal_fetal_cardiomyocyte1.52611883
51MP0003984_embryonic_growth_retardation1.49415232
52MP0004145_abnormal_muscle_electrophysio1.49214630
53MP0002088_abnormal_embryonic_growth/wei1.47516913
54MP0000747_muscle_weakness1.45678913
55MP0003186_abnormal_redox_activity1.44223960
56MP0003300_gastrointestinal_ulcer1.43283012
57MP0005083_abnormal_biliary_tract1.34764071
58MP0004084_abnormal_cardiac_muscle1.34275574
59MP0003119_abnormal_digestive_system1.33355683
60MP0009278_abnormal_bone_marrow1.33266790
61MP0009672_abnormal_birth_weight1.29672188
62MP0008872_abnormal_physiological_respon1.28296869
63MP0002086_abnormal_extraembryonic_tissu1.27408842
64MP0008995_early_reproductive_senescence1.26787161
65MP0002398_abnormal_bone_marrow1.26763500
66MP0000428_abnormal_craniofacial_morphol1.26237875
67MP0000750_abnormal_muscle_regeneration1.22282556
68MP0001849_ear_inflammation1.20828321
69MP0004087_abnormal_muscle_fiber1.20373128
70MP0000313_abnormal_cell_death1.19965798
71MP0001929_abnormal_gametogenesis1.19400123
72MP0000689_abnormal_spleen_morphology1.18444782
73MP0002160_abnormal_reproductive_system1.17808603
74MP0002269_muscular_atrophy1.16954165
75MP0002722_abnormal_immune_system1.16491740
76MP0002106_abnormal_muscle_physiology1.16001402
77MP0005187_abnormal_penis_morphology1.15464061
78MP0004043_abnormal_pH_regulation1.15166694
79MP0003115_abnormal_respiratory_system1.14749158
80MP0000759_abnormal_skeletal_muscle1.13977847
81MP0005646_abnormal_pituitary_gland1.13913859
82MP0000015_abnormal_ear_pigmentation1.12214388
83MP0003786_premature_aging1.12057286
84MP0000465_gastrointestinal_hemorrhage1.09827256
85MP0003122_maternal_imprinting1.06221930
86MP0002210_abnormal_sex_determination1.06160238
87MP0005220_abnormal_exocrine_pancreas1.06014655
88MP0002019_abnormal_tumor_incidence1.05521419
89MP0003656_abnormal_erythrocyte_physiolo1.04331794
90MP0008875_abnormal_xenobiotic_pharmacok1.04001740
91MP0010630_abnormal_cardiac_muscle1.02459716
92MP0001764_abnormal_homeostasis1.01716053
93MP0000703_abnormal_thymus_morphology1.01064226
94MP0000490_abnormal_crypts_of1.00189418
95MP0001145_abnormal_male_reproductive1.00106987
96MP0002009_preneoplasia0.99905837
97MP0003943_abnormal_hepatobiliary_system0.98458184
98MP0002166_altered_tumor_susceptibility0.97180804
99MP0000427_abnormal_hair_cycle0.96926913
100MP0003787_abnormal_imprinting0.96474237
101MP0002234_abnormal_pharynx_morphology0.95918959
102MP0009703_decreased_birth_body0.93361886
103MP0002102_abnormal_ear_morphology0.93173041
104MP0002429_abnormal_blood_cell0.92963177
105MP0000749_muscle_degeneration0.92677616
106MP0002089_abnormal_postnatal_growth/wei0.92629891
107MP0002970_abnormal_white_adipose0.91872112
108MP0004185_abnormal_adipocyte_glucose0.91865943
109MP0005369_muscle_phenotype0.91689475
110MP0004036_abnormal_muscle_relaxation0.90234359
111MP0008775_abnormal_heart_ventricle0.89030433
112MP0003935_abnormal_craniofacial_develop0.88837832
113MP0008438_abnormal_cutaneous_collagen0.87629347
114MP0000653_abnormal_sex_gland0.87570474
115MP0008770_decreased_survivor_rate0.87559302
116MP0005408_hypopigmentation0.87380161
117MP0003698_abnormal_male_reproductive0.87053047
118MP0001293_anophthalmia0.86515023
119MP0000358_abnormal_cell_content/0.86279394
120MP0002736_abnormal_nociception_after0.85995131
121MP0000266_abnormal_heart_morphology0.85174449
122MP0003566_abnormal_cell_adhesion0.85080774
123MP0001835_abnormal_antigen_presentation0.83390184
124MP0009333_abnormal_splenocyte_physiolog0.82571518
125MP0008961_abnormal_basal_metabolism0.82561767
126MP0009053_abnormal_anal_canal0.80601271
127MP0002092_abnormal_eye_morphology0.80587061
128MP0005389_reproductive_system_phenotype0.78913443
129MP0003866_abnormal_defecation0.77717337
130MP0002132_abnormal_respiratory_system0.77329833
131MP0002925_abnormal_cardiovascular_devel0.75997327
132MP0003861_abnormal_nervous_system0.75726102
133MP0000598_abnormal_liver_morphology0.75497796
134MP0002095_abnormal_skin_pigmentation0.74250101
135MP0003959_abnormal_lean_body0.74130657
136MP0005503_abnormal_tendon_morphology0.73894540
137MP0005266_abnormal_metabolism0.73583987
138MP0002006_tumorigenesis0.72486951
139MP0001529_abnormal_vocalization0.72047939
140MP0005174_abnormal_tail_pigmentation0.72017780
141MP0005330_cardiomyopathy0.71956499
142MP0000569_abnormal_digit_pigmentation0.71889627
143MP0003942_abnormal_urinary_system0.71671747
144MP0002938_white_spotting0.71565098
145MP0002114_abnormal_axial_skeleton0.70756134
146MP0005384_cellular_phenotype0.70221060
147MP0002932_abnormal_joint_morphology0.69995957
148MP0004215_abnormal_myocardial_fiber0.69641709
149MP0001119_abnormal_female_reproductive0.69437558
150MP0010234_abnormal_vibrissa_follicle0.69087339
151MP0003385_abnormal_body_wall0.68545094
152MP0005275_abnormal_skin_tensile0.68441022
153MP0005397_hematopoietic_system_phenotyp0.68147305
154MP0001545_abnormal_hematopoietic_system0.68147305
155MP0008873_increased_physiological_sensi0.67713591
156MP0005551_abnormal_eye_electrophysiolog0.67258266
157MP0005332_abnormal_amino_acid0.67067786
158MP0004264_abnormal_extraembryonic_tissu0.66407378
159MP0000383_abnormal_hair_follicle0.65799734
160MP0005395_other_phenotype0.65742533
161MP0003646_muscle_fatigue0.64979159
162MP0002163_abnormal_gland_morphology0.63768556
163MP0005636_abnormal_mineral_homeostasis0.63588961
164MP0001881_abnormal_mammary_gland0.63206627
165MP0000716_abnormal_immune_system0.62703519
166MP0002083_premature_death0.62632707
167MP0002075_abnormal_coat/hair_pigmentati0.61204983
168MP0006072_abnormal_retinal_apoptosis0.57042706

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.14402668
2Chromsome breakage (HP:0040012)3.84055019
3Microvesicular hepatic steatosis (HP:0001414)3.76282412
4Renal cortical cysts (HP:0000803)3.71554154
5Hyperacusis (HP:0010780)3.51509664
6Short 4th metacarpal (HP:0010044)3.36321764
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.36321764
8Medulloblastoma (HP:0002885)3.32932415
9Ependymoma (HP:0002888)3.27550827
10Type I transferrin isoform profile (HP:0003642)3.24028691
11Abnormal protein glycosylation (HP:0012346)3.15641120
12Abnormal glycosylation (HP:0012345)3.15641120
13Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.15641120
14Abnormal protein N-linked glycosylation (HP:0012347)3.15641120
15Hepatic necrosis (HP:0002605)3.12369783
16Increased nuchal translucency (HP:0010880)3.07172893
17Dyschromatopsia (HP:0007641)3.06125916
18Panhypogammaglobulinemia (HP:0003139)2.97915933
19Hepatocellular necrosis (HP:0001404)2.97913372
20Abnormality of the calcaneus (HP:0008364)2.95443930
21Myelodysplasia (HP:0002863)2.95304867
22Colon cancer (HP:0003003)2.89559392
23Increased serum lactate (HP:0002151)2.88524248
24Renal duplication (HP:0000075)2.86991542
25Reticulocytopenia (HP:0001896)2.82084590
26Pelvic girdle muscle weakness (HP:0003749)2.80314455
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79837510
28Abnormality of alanine metabolism (HP:0010916)2.79837510
29Hyperalaninemia (HP:0003348)2.79837510
30Shoulder girdle muscle weakness (HP:0003547)2.78596865
31Calcaneovalgus deformity (HP:0001848)2.78179028
32Abnormality of the preputium (HP:0100587)2.77495096
33Myopathic facies (HP:0002058)2.73985737
34Pancytopenia (HP:0001876)2.73549011
35Abnormality of the renal cortex (HP:0011035)2.68041110
36Ankle contracture (HP:0006466)2.66492383
373-Methylglutaconic aciduria (HP:0003535)2.64464484
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.63044621
39Type 1 muscle fiber predominance (HP:0003803)2.61924093
40Insomnia (HP:0100785)2.59177026
41Deformed tarsal bones (HP:0008119)2.58483452
42Abnormality of the 4th metacarpal (HP:0010012)2.54643128
43Testicular atrophy (HP:0000029)2.50858023
44Lactic acidosis (HP:0003128)2.50789600
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.47816509
46Elfin facies (HP:0004428)2.45859912
47Increased CSF lactate (HP:0002490)2.44938384
48Selective tooth agenesis (HP:0001592)2.43099812
49Glioma (HP:0009733)2.42592415
50Ulnar deviation of the wrist (HP:0003049)2.42469905
51Meckel diverticulum (HP:0002245)2.42322039
52Abnormality of the hip-girdle musculature (HP:0001445)2.42175527
53Abnormality of the musculature of the pelvis (HP:0001469)2.42175527
54Bowel diverticulosis (HP:0005222)2.41886997
55Duplicated collecting system (HP:0000081)2.41547123
56Overriding aorta (HP:0002623)2.40125090
57Abnormality of the ileum (HP:0001549)2.38768048
58Basal cell carcinoma (HP:0002671)2.37220865
59Astrocytoma (HP:0009592)2.36791435
60Abnormality of the astrocytes (HP:0100707)2.36791435
61Breast hypoplasia (HP:0003187)2.36154681
62Small intestinal stenosis (HP:0012848)2.32360419
63Duodenal stenosis (HP:0100867)2.32360419
64Rimmed vacuoles (HP:0003805)2.31078508
65Abnormality of chromosome stability (HP:0003220)2.29719157
66Protrusio acetabuli (HP:0003179)2.28972686
67Ragged-red muscle fibers (HP:0003200)2.28128727
68Exercise-induced muscle cramps (HP:0003710)2.27503822
69Angiofibromas (HP:0010615)2.26567932
70Adenoma sebaceum (HP:0009720)2.26567932
71Proximal placement of thumb (HP:0009623)2.24587803
72Acute encephalopathy (HP:0006846)2.23727993
73Progressive microcephaly (HP:0000253)2.23678749
74Abnormality of cells of the erythroid lineage (HP:0012130)2.23627548
75Renovascular hypertension (HP:0100817)2.22787621
76Abnormality of T cell physiology (HP:0011840)2.22692786
77Abnormal mitochondria in muscle tissue (HP:0008316)2.19980992
78Limb-girdle muscle atrophy (HP:0003797)2.19959778
79Pancreatic cysts (HP:0001737)2.18313933
80Muscle fiber inclusion bodies (HP:0100299)2.18061135
81Limb-girdle muscle weakness (HP:0003325)2.17909804
82Cerebral aneurysm (HP:0004944)2.17841565
83Shallow orbits (HP:0000586)2.17647354
84Mitochondrial inheritance (HP:0001427)2.16530297
85Neoplasm of striated muscle (HP:0009728)2.15931649
86Agammaglobulinemia (HP:0004432)2.15259769
87Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.14916806
88Increased density of long bones (HP:0006392)2.14757219
89Volvulus (HP:0002580)2.14584120
90Sloping forehead (HP:0000340)2.14373537
91Rhabdomyosarcoma (HP:0002859)2.13462206
92Progressive muscle weakness (HP:0003323)2.12576850
93Prolonged bleeding time (HP:0003010)2.12169913
94Abnormal number of erythroid precursors (HP:0012131)2.11218309
95Petechiae (HP:0000967)2.11176775
96Clubbing of toes (HP:0100760)2.10852342
97Abnormality of B cell number (HP:0010975)2.10734789
98Distal arthrogryposis (HP:0005684)2.09316218
99Deviation of the thumb (HP:0009603)2.08712219
100Acute lymphatic leukemia (HP:0006721)2.08040180
101Pointed chin (HP:0000307)2.05011695
102Flat cornea (HP:0007720)2.04302259
103Wrist flexion contracture (HP:0001239)2.03647736
104Difficulty climbing stairs (HP:0003551)2.03376112
105Microretrognathia (HP:0000308)2.02496791
106Reduced antithrombin III activity (HP:0001976)2.02085296
107Adducted thumb (HP:0001181)1.99186043
108Cerebral hypomyelination (HP:0006808)1.99017028
109Absent thumb (HP:0009777)1.98882825
110Missing ribs (HP:0000921)1.98300163
111Intestinal polyp (HP:0005266)1.98264638
112Abnormality of the renal collecting system (HP:0004742)1.97748451
113Bladder diverticulum (HP:0000015)1.96980061
11411 pairs of ribs (HP:0000878)1.96529459
115High pitched voice (HP:0001620)1.96187244
116Cutaneous melanoma (HP:0012056)1.94122363
117CNS demyelination (HP:0007305)1.93361926
118Central scotoma (HP:0000603)1.93308334
119Slender long bone (HP:0003100)1.92951711
120Opisthotonus (HP:0002179)1.92705261
121Intestinal polyposis (HP:0200008)1.92591820
122Tinnitus (HP:0000360)1.92512392
123B lymphocytopenia (HP:0010976)1.92361351
124Brushfield spots (HP:0001088)1.92308516
125Increased intramyocellular lipid droplets (HP:0012240)1.92047977
126Cerebral palsy (HP:0100021)1.92034006
127Nemaline bodies (HP:0003798)1.91712180
128Acute necrotizing encephalopathy (HP:0006965)1.89600161
129Increased connective tissue (HP:0009025)1.89432543
130Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89352442
131Dicarboxylic aciduria (HP:0003215)1.89352442
132Bile duct proliferation (HP:0001408)1.89247853
133Abnormal biliary tract physiology (HP:0012439)1.89247853
134Ketosis (HP:0001946)1.89133551
135Broad palm (HP:0001169)1.88686562
136Patellar aplasia (HP:0006443)1.88251673
137Megalocornea (HP:0000485)1.87975300
138IgA deficiency (HP:0002720)1.87421899
139Ketoacidosis (HP:0001993)1.85871964
140Neoplasm of the pancreas (HP:0002894)1.85584237
141Severe combined immunodeficiency (HP:0004430)1.85312743
142Abnormality of DNA repair (HP:0003254)1.84649261
143Premature ovarian failure (HP:0008209)1.84356415
144Aplasia/Hypoplasia of the patella (HP:0006498)1.84306598
145IgM deficiency (HP:0002850)1.83839763
146Abnormality of methionine metabolism (HP:0010901)1.83817112
147Hyperglycinuria (HP:0003108)1.83514778
148Squamous cell carcinoma (HP:0002860)1.83411105
149Enlarged penis (HP:0000040)1.83164319
150Spastic paraparesis (HP:0002313)1.82580366
151Emotional lability (HP:0000712)1.81979474
152Abnormality of glycolysis (HP:0004366)1.79639852
153CNS hypomyelination (HP:0003429)1.79427627
154Birth length less than 3rd percentile (HP:0003561)1.79411745
155Trigonocephaly (HP:0000243)1.77819848
156Subaortic stenosis (HP:0001682)1.77175800
157Abnormality of the left ventricular outflow tract (HP:0011103)1.77175800
158Neoplasm of the heart (HP:0100544)1.76930969
159Acute hepatic failure (HP:0006554)1.76293475
160Bicuspid aortic valve (HP:0001647)1.76036402
161Degeneration of anterior horn cells (HP:0002398)1.75593280
162Abnormality of the anterior horn cell (HP:0006802)1.75593280
163Cerebellar dysplasia (HP:0007033)1.74993095
164Fibroma (HP:0010614)1.74770645
165IgG deficiency (HP:0004315)1.74630668
166Hyperammonemia (HP:0001987)1.74621657
167Nephronophthisis (HP:0000090)1.74403329
168Abnormality of the pons (HP:0007361)1.74377158
169Abnormality of the carotid arteries (HP:0005344)1.74250603
170Secondary amenorrhea (HP:0000869)1.74084141
171Fibrous tissue neoplasm (HP:0012316)1.73829480
172Difficulty running (HP:0009046)1.73206688
173Bone marrow hypocellularity (HP:0005528)1.71705048
174Cafe-au-lait spot (HP:0000957)1.71514128
175Atresia of the external auditory canal (HP:0000413)1.71421712
176Freckling (HP:0001480)1.67451320
177Ovarian neoplasm (HP:0100615)1.65778636
178Long toe (HP:0010511)1.65098060
179Aplastic anemia (HP:0001915)1.62556459
180Slender build (HP:0001533)1.61969325
181Exercise-induced myalgia (HP:0003738)1.61840613
182Atrophy/Degeneration involving motor neurons (HP:0007373)1.61714298
183Rectal prolapse (HP:0002035)1.61618600
184Genu recurvatum (HP:0002816)1.60386436
185Sacral dimple (HP:0000960)1.59790429
186Lymphangioma (HP:0100764)1.59298459
187Thrombocytosis (HP:0001894)1.58496065
188Prominent nose (HP:0000448)1.58149730
189Carpal bone hypoplasia (HP:0001498)1.57736029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.87362270
2CDC73.64598908
3EEF2K3.60032309
4PKN23.57091821
5ZAK3.30348942
6PBK3.27434157
7BUB12.99261656
8NEK12.74705545
9NEK22.67613605
10WEE12.61634834
11MAP3K102.60888160
12SCYL22.53383502
13TTN2.48832463
14VRK22.47161957
15PASK2.36967809
16BCKDK2.35017902
17NUAK12.26929898
18NME12.18934296
19EIF2AK32.06807704
20BMPR1B2.01498228
21FRK1.90004151
22BRSK21.86613151
23SRPK11.81929373
24TAOK31.80247528
25PLK41.76300984
26BRSK11.69211185
27FLT31.65210635
28TEC1.61868591
29ACVR1B1.60733481
30CDK41.57278740
31TGFBR11.57222416
32TESK21.55833122
33TXK1.53764647
34LRRK21.50518945
35ATR1.46745812
36TTK1.46278572
37DYRK31.44373991
38MAP4K21.42657100
39FES1.42215427
40VRK11.41869571
41RPS6KB21.36347720
42PDK21.33149547
43EIF2AK11.29536801
44PAK41.28584894
45AURKB1.27918684
46PLK11.25739806
47CDK61.18096952
48CDK81.13417869
49TLK11.12100053
50CDK121.11559349
51CHEK21.11060599
52DAPK11.10580538
53MAP3K81.08186269
54TSSK61.07916099
55MAP3K61.05395437
56RPS6KA41.03529925
57BTK1.00899270
58RIPK11.00452714
59ALK0.99700706
60ILK0.97620701
61MKNK10.96013603
62PDGFRA0.95650988
63CHEK10.90247420
64CDK70.89830425
65CCNB10.89578844
66MAPKAPK30.85545041
67TESK10.85007327
68RIPK40.83635133
69STK160.83006526
70MTOR0.82628640
71MAP2K60.82093811
72NME20.81595519
73BMPR20.81428668
74MAP2K30.80889986
75MAPKAPK50.80163447
76RAF10.79865430
77AURKA0.79474087
78PTK60.79395341
79STK100.78950744
80BMX0.76733891
81CDK20.74421372
82EIF2AK20.74285012
83PAK20.69668949
84SYK0.69340593
85KSR10.69074531
86LIMK10.68830584
87PIM20.68504481
88TRPM70.67415737
89WNK40.66476617
90PLK30.66098602
91TAOK10.65058071
92UHMK10.64580056
93PHKG10.63166021
94PHKG20.63166021
95STK40.62085362
96MAP4K10.61332823
97SMG10.60149545
98RET0.59830787
99MAP2K20.59548431
100CDK90.59450316
101MKNK20.58645422
102ITK0.58071785
103INSRR0.57399315
104CDK11A0.56570352
105MAP3K110.56033945
106MAPK130.55486471
107GRK60.55207185
108CDK150.54544708
109MAP3K40.53708577
110AKT20.53426612
111CDK10.53042850
112* ATM0.52362492
113PTK2B0.51798237
114CDK180.50772702
115CDK140.50257997
116CAMKK20.48821301
117PAK10.48521246
118CSNK1G30.48072198
119KSR20.46015426
120RPS6KA50.45585375
121FGFR10.44216685
122BRD40.43391558
123MST40.42707829
124DYRK1B0.42581846
125PIK3CG0.41945309
126MARK10.41054016
127PRKCI0.40845092
128OBSCN0.40821577
129MAPK90.40626770
130* PRKDC0.40117332
131MAP2K10.40010925
132KDR0.39866426
133CSNK2A10.39566643
134CLK10.37989385
135PDK30.37647045
136PDK40.37647045
137KIT0.36708164
138CSNK2A20.35604457
139RPS6KA20.34860962
140MAP3K50.33734085
141CSNK1A1L0.32938841
142HCK0.32658803
143IKBKB0.31548003
144CSNK1G10.31293179
145HIPK20.30990213
146MARK30.29783374
147RPS6KA10.29630449
148CSNK1E0.28527199
149PRKCQ0.28137492
150MAPK110.27567867
151MAPKAPK20.27301222
152ZAP700.26400915
153MELK0.26300481

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.03954170
2Mismatch repair_Homo sapiens_hsa034303.64193643
3Spliceosome_Homo sapiens_hsa030402.87405289
4* Cell cycle_Homo sapiens_hsa041102.80539417
5Base excision repair_Homo sapiens_hsa034102.80268616
6RNA transport_Homo sapiens_hsa030132.61672692
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33829074
8Nucleotide excision repair_Homo sapiens_hsa034202.33717606
9Ribosome_Homo sapiens_hsa030102.22308424
10Homologous recombination_Homo sapiens_hsa034402.02544417
11mRNA surveillance pathway_Homo sapiens_hsa030151.96027381
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94880062
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74069443
14* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.73747688
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69804508
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69167438
17Fatty acid elongation_Homo sapiens_hsa000621.57990640
18* Oocyte meiosis_Homo sapiens_hsa041141.52830348
19One carbon pool by folate_Homo sapiens_hsa006701.52492716
20Sulfur relay system_Homo sapiens_hsa041221.48357686
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41259299
22Chronic myeloid leukemia_Homo sapiens_hsa052201.40001366
23Propanoate metabolism_Homo sapiens_hsa006401.36671824
24* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31155800
25Viral carcinogenesis_Homo sapiens_hsa052031.29367595
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26868058
27Non-homologous end-joining_Homo sapiens_hsa034501.26468158
28Colorectal cancer_Homo sapiens_hsa052101.24791850
29RNA degradation_Homo sapiens_hsa030181.23780915
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.23393846
31Proteasome_Homo sapiens_hsa030501.22739964
32Pyrimidine metabolism_Homo sapiens_hsa002401.21210737
33p53 signaling pathway_Homo sapiens_hsa041151.18099032
34Primary immunodeficiency_Homo sapiens_hsa053401.17487797
35Fanconi anemia pathway_Homo sapiens_hsa034601.11088039
36Protein export_Homo sapiens_hsa030601.11001816
37Systemic lupus erythematosus_Homo sapiens_hsa053221.10809109
38* HTLV-I infection_Homo sapiens_hsa051661.09528960
39Nitrogen metabolism_Homo sapiens_hsa009101.08122121
40Epstein-Barr virus infection_Homo sapiens_hsa051691.07429379
41Notch signaling pathway_Homo sapiens_hsa043301.06379038
42Non-small cell lung cancer_Homo sapiens_hsa052231.05117160
43MicroRNAs in cancer_Homo sapiens_hsa052061.05057349
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.04629984
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04404436
46Butanoate metabolism_Homo sapiens_hsa006501.03273928
47RNA polymerase_Homo sapiens_hsa030201.02148600
48Peroxisome_Homo sapiens_hsa041461.01939833
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.01797803
50mTOR signaling pathway_Homo sapiens_hsa041501.01700982
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.99965625
52Thyroid cancer_Homo sapiens_hsa052160.99794378
53Alcoholism_Homo sapiens_hsa050340.99135419
54Bladder cancer_Homo sapiens_hsa052190.98539169
55Parkinsons disease_Homo sapiens_hsa050120.98359883
56Small cell lung cancer_Homo sapiens_hsa052220.97797320
57Oxidative phosphorylation_Homo sapiens_hsa001900.92789926
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92359570
59N-Glycan biosynthesis_Homo sapiens_hsa005100.91707030
60Viral myocarditis_Homo sapiens_hsa054160.90844956
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88719382
62VEGF signaling pathway_Homo sapiens_hsa043700.88202600
63Pyruvate metabolism_Homo sapiens_hsa006200.86293553
64Insulin signaling pathway_Homo sapiens_hsa049100.86055397
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85629266
66Basal cell carcinoma_Homo sapiens_hsa052170.83609506
67Endometrial cancer_Homo sapiens_hsa052130.83167311
68Huntingtons disease_Homo sapiens_hsa050160.82305579
69Glutathione metabolism_Homo sapiens_hsa004800.82256578
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81802568
71Pancreatic cancer_Homo sapiens_hsa052120.81712318
72Glioma_Homo sapiens_hsa052140.80670089
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79310797
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79224828
75Focal adhesion_Homo sapiens_hsa045100.77886355
76Hippo signaling pathway_Homo sapiens_hsa043900.77286937
77AMPK signaling pathway_Homo sapiens_hsa041520.77233510
78Antigen processing and presentation_Homo sapiens_hsa046120.77006676
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73670045
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72131268
81Acute myeloid leukemia_Homo sapiens_hsa052210.71842116
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71453681
83Fatty acid metabolism_Homo sapiens_hsa012120.69850344
84Hedgehog signaling pathway_Homo sapiens_hsa043400.69366603
85Proteoglycans in cancer_Homo sapiens_hsa052050.68437763
86Biosynthesis of amino acids_Homo sapiens_hsa012300.67843285
87Metabolic pathways_Homo sapiens_hsa011000.67602936
88Shigellosis_Homo sapiens_hsa051310.66524945
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64102372
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63645226
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62748865
92Hepatitis B_Homo sapiens_hsa051610.62287239
93Herpes simplex infection_Homo sapiens_hsa051680.61514701
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61126671
95Lysine degradation_Homo sapiens_hsa003100.60046216
96Linoleic acid metabolism_Homo sapiens_hsa005910.59492717
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59387949
98Pentose phosphate pathway_Homo sapiens_hsa000300.58781569
99Carbon metabolism_Homo sapiens_hsa012000.57638105
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57627247
101Renal cell carcinoma_Homo sapiens_hsa052110.56335833
102Basal transcription factors_Homo sapiens_hsa030220.56303565
103Selenocompound metabolism_Homo sapiens_hsa004500.56263951
104Adherens junction_Homo sapiens_hsa045200.55190077
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55181867
106Purine metabolism_Homo sapiens_hsa002300.55143293
107Pathways in cancer_Homo sapiens_hsa052000.54784081
108HIF-1 signaling pathway_Homo sapiens_hsa040660.54768775
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54234192
110Insulin resistance_Homo sapiens_hsa049310.53967819
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53621832
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52755553
113Glucagon signaling pathway_Homo sapiens_hsa049220.51359332
114Arachidonic acid metabolism_Homo sapiens_hsa005900.49909515
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49871013
116FoxO signaling pathway_Homo sapiens_hsa040680.48913375
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48708235
118Apoptosis_Homo sapiens_hsa042100.48674241
119Regulation of autophagy_Homo sapiens_hsa041400.48503586
120Dilated cardiomyopathy_Homo sapiens_hsa054140.48093925
121Wnt signaling pathway_Homo sapiens_hsa043100.48017619
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47104700
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45707938
124Platelet activation_Homo sapiens_hsa046110.45606154
125Phototransduction_Homo sapiens_hsa047440.45387116
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43887816
127Tight junction_Homo sapiens_hsa045300.43646822
128Glycerolipid metabolism_Homo sapiens_hsa005610.43412967
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42953784
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42205053
131Prostate cancer_Homo sapiens_hsa052150.41357035
132TGF-beta signaling pathway_Homo sapiens_hsa043500.40944293
133Prolactin signaling pathway_Homo sapiens_hsa049170.40896877
134Estrogen signaling pathway_Homo sapiens_hsa049150.40715024
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.39392678
136B cell receptor signaling pathway_Homo sapiens_hsa046620.39070873
137Caffeine metabolism_Homo sapiens_hsa002320.36675725
138beta-Alanine metabolism_Homo sapiens_hsa004100.36617937
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.35218907
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34696325
141Tryptophan metabolism_Homo sapiens_hsa003800.33879820
142Alzheimers disease_Homo sapiens_hsa050100.30966867
143Fructose and mannose metabolism_Homo sapiens_hsa000510.30248711
144Arginine and proline metabolism_Homo sapiens_hsa003300.30179823
145ABC transporters_Homo sapiens_hsa020100.30043347
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29580870
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.27967050
148Fatty acid degradation_Homo sapiens_hsa000710.23500548
149Ether lipid metabolism_Homo sapiens_hsa005650.21992771
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19763152
151Intestinal immune network for IgA production_Homo sapiens_hsa046720.19323418
152Tyrosine metabolism_Homo sapiens_hsa003500.19207087
153Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17721282
154Glycosaminoglycan degradation_Homo sapiens_hsa005310.17407194
155Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15415544
156Sphingolipid metabolism_Homo sapiens_hsa006000.15374223
157Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15050625
158Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13977597
159Other glycan degradation_Homo sapiens_hsa005110.13963816
160Chemical carcinogenesis_Homo sapiens_hsa052040.12671872

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