ANG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.58468294
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.58468294
3epoxygenase P450 pathway (GO:0019373)7.34595400
4L-phenylalanine metabolic process (GO:0006558)7.25950056
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.25950056
6exogenous drug catabolic process (GO:0042738)7.00293307
7omega-hydroxylase P450 pathway (GO:0097267)6.93244368
8aromatic amino acid family catabolic process (GO:0009074)6.73426019
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.26033671
10tryptophan catabolic process (GO:0006569)6.01046984
11indole-containing compound catabolic process (GO:0042436)6.01046984
12indolalkylamine catabolic process (GO:0046218)6.01046984
13bile acid biosynthetic process (GO:0006699)5.79185318
14kynurenine metabolic process (GO:0070189)5.78674318
15tryptophan metabolic process (GO:0006568)5.68483868
16high-density lipoprotein particle remodeling (GO:0034375)5.67860916
17negative regulation of fibrinolysis (GO:0051918)5.58923471
18regulation of plasminogen activation (GO:0010755)5.57819190
19glyoxylate metabolic process (GO:0046487)5.51745417
20urea metabolic process (GO:0019627)5.51477645
21urea cycle (GO:0000050)5.51477645
22peptidyl-glutamic acid carboxylation (GO:0017187)5.49106875
23protein carboxylation (GO:0018214)5.49106875
24ethanol metabolic process (GO:0006067)5.43499796
25regulation of fibrinolysis (GO:0051917)5.41116803
26complement activation, alternative pathway (GO:0006957)5.40478590
27regulation of protein activation cascade (GO:2000257)5.35900170
28cysteine metabolic process (GO:0006534)5.32251012
29drug metabolic process (GO:0017144)5.24210399
30regulation of cholesterol esterification (GO:0010872)5.18433852
31sulfur amino acid catabolic process (GO:0000098)5.17084258
32alpha-linolenic acid metabolic process (GO:0036109)5.14619453
33nitrogen cycle metabolic process (GO:0071941)5.08308086
34regulation of complement activation (GO:0030449)4.98316361
35bile acid metabolic process (GO:0008206)4.96628431
36serine family amino acid catabolic process (GO:0009071)4.90756163
37aromatic amino acid family metabolic process (GO:0009072)4.89856954
38reverse cholesterol transport (GO:0043691)4.85881653
39phospholipid efflux (GO:0033700)4.81308758
40protein-lipid complex remodeling (GO:0034368)4.80492281
41macromolecular complex remodeling (GO:0034367)4.80492281
42plasma lipoprotein particle remodeling (GO:0034369)4.80492281
43regulation of triglyceride catabolic process (GO:0010896)4.78346481
44tyrosine metabolic process (GO:0006570)4.76371745
45negative regulation of hemostasis (GO:1900047)4.70153449
46negative regulation of blood coagulation (GO:0030195)4.70153449
47homocysteine metabolic process (GO:0050667)4.67836737
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.66076381
49negative regulation of sterol transport (GO:0032372)4.62520196
50negative regulation of cholesterol transport (GO:0032375)4.62520196
51oxidative demethylation (GO:0070989)4.61062599
52regulation of humoral immune response (GO:0002920)4.54976924
53phenylpropanoid metabolic process (GO:0009698)4.54668579
54acylglycerol homeostasis (GO:0055090)4.50985614
55triglyceride homeostasis (GO:0070328)4.50985614
56alpha-amino acid catabolic process (GO:1901606)4.48635107
57amino-acid betaine metabolic process (GO:0006577)4.42782034
58plasma lipoprotein particle clearance (GO:0034381)4.35038994
59negative regulation of coagulation (GO:0050819)4.32764582
60coenzyme catabolic process (GO:0009109)4.31098258
61indolalkylamine metabolic process (GO:0006586)4.28629947
62cholesterol efflux (GO:0033344)4.28601240
63lysine metabolic process (GO:0006553)4.28459520
64lysine catabolic process (GO:0006554)4.28459520
65bile acid and bile salt transport (GO:0015721)4.27531801
66cellular biogenic amine catabolic process (GO:0042402)4.22084536
67amine catabolic process (GO:0009310)4.22084536
68negative regulation of wound healing (GO:0061045)4.20787520
69positive regulation of hemostasis (GO:1900048)4.13554282
70positive regulation of blood coagulation (GO:0030194)4.13554282
71glycine metabolic process (GO:0006544)4.13404074
72cellular amino acid catabolic process (GO:0009063)4.13235912
73fibrinolysis (GO:0042730)4.12820960
74cellular ketone body metabolic process (GO:0046950)4.11820397
75negative regulation of complement activation (GO:0045916)4.11225554
76cellular glucuronidation (GO:0052695)4.10992534
77benzene-containing compound metabolic process (GO:0042537)4.10632343
78imidazole-containing compound metabolic process (GO:0052803)4.08625921
79plasma lipoprotein particle assembly (GO:0034377)4.04459011
80cellular modified amino acid catabolic process (GO:0042219)4.03943241
81glutamate metabolic process (GO:0006536)3.98443117
82negative regulation of lipase activity (GO:0060192)3.98277264
83serine family amino acid metabolic process (GO:0009069)3.96841580
84positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.95955138
85low-density lipoprotein particle remodeling (GO:0034374)3.94507471
86acute-phase response (GO:0006953)3.92846095
87intestinal cholesterol absorption (GO:0030299)3.90579973
88aldehyde catabolic process (GO:0046185)3.90479983
89arginine metabolic process (GO:0006525)3.86454881
90drug catabolic process (GO:0042737)3.84212684
91complement activation, classical pathway (GO:0006958)3.84129706
92positive regulation of coagulation (GO:0050820)3.82025672
93blood coagulation, intrinsic pathway (GO:0007597)3.82002487
94protein-lipid complex subunit organization (GO:0071825)3.81584942
95very-low-density lipoprotein particle assembly (GO:0034379)3.80379266
96regulation of apoptotic cell clearance (GO:2000425)3.80328473
97complement activation (GO:0006956)3.79362583
98cofactor catabolic process (GO:0051187)3.78163688
99protein activation cascade (GO:0072376)3.77258227
100serine family amino acid biosynthetic process (GO:0009070)3.74675933
101ethanol oxidation (GO:0006069)3.72379249
102heme transport (GO:0015886)3.70907699
103positive regulation of lipid catabolic process (GO:0050996)3.70125169
104regulation of bile acid biosynthetic process (GO:0070857)3.69379344
105opsonization (GO:0008228)3.69236297
106dicarboxylic acid biosynthetic process (GO:0043650)3.68820862
107positive regulation of lipoprotein lipase activity (GO:0051006)3.68717657
108positive regulation of triglyceride lipase activity (GO:0061365)3.68717657
109glucuronate metabolic process (GO:0019585)3.68148585
110uronic acid metabolic process (GO:0006063)3.68148585
111cholesterol homeostasis (GO:0042632)3.67103597
112organic acid catabolic process (GO:0016054)3.63547761
113carboxylic acid catabolic process (GO:0046395)3.63547761
114plasma lipoprotein particle organization (GO:0071827)3.62805199
115sterol homeostasis (GO:0055092)3.60886731
116protein-lipid complex assembly (GO:0065005)3.58647177
117S-adenosylmethionine metabolic process (GO:0046500)3.57997630
118short-chain fatty acid metabolic process (GO:0046459)3.57596569
119positive regulation of fatty acid biosynthetic process (GO:0045723)3.55854825
120ketone body metabolic process (GO:1902224)3.55576422
121acute inflammatory response (GO:0002526)3.55052322
122negative regulation of protein activation cascade (GO:2000258)3.55026412
123disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.54556871
124killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.54556871
125cytolysis (GO:0019835)3.53615508
126alkaloid metabolic process (GO:0009820)3.44199596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.08794624
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.93883474
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.92339083
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.29169469
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24576418
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.19005489
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.63680590
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.96794408
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.91519830
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01415023
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6220182
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97364172
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93538280
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86297154
15GATA1_22025678_ChIP-Seq_K562_Human1.69438410
16* FOXA2_19822575_ChIP-Seq_HepG2_Human1.54623001
17CLOCK_20551151_ChIP-Seq_293T_Human1.52019355
18HTT_18923047_ChIP-ChIP_STHdh_Human1.51659164
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47239115
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44517220
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.35501483
22* HNF4A_19822575_ChIP-Seq_HepG2_Human1.31823659
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23755505
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16502623
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05976295
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04779259
27* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03597560
28* IRF8_22096565_ChIP-ChIP_GC-B_Human0.99341785
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99320485
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96635137
31GATA4_25053715_ChIP-Seq_YYC3_Human0.95047672
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93381965
33RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92905085
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91628723
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91246345
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83887996
37ESR2_21235772_ChIP-Seq_MCF-7_Human0.80995163
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80346801
39KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79125875
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78448531
41ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77288778
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76829415
43AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76325550
44ESR1_21235772_ChIP-Seq_MCF-7_Human0.76186139
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76042638
46SOX2_21211035_ChIP-Seq_LN229_Human0.73836985
47TCF4_18268006_ChIP-ChIP_LS174T_Human0.73764920
48BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73363982
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73283268
50NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73283268
51* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72276515
52SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72038560
53RAC3_21632823_ChIP-Seq_H3396_Human0.71946790
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71857557
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71531391
56RARA_24833708_ChIP-Seq_LIVER_Mouse0.70092162
57SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67826784
58MYC_19829295_ChIP-Seq_ESCs_Human0.65868638
59CDX2_19796622_ChIP-Seq_MESCs_Mouse0.65401663
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.64684249
61SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64537981
62FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64353845
63HNFA_21074721_ChIP-Seq_CACO-2_Human0.64175021
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63470671
65TP53_18474530_ChIP-ChIP_U2OS_Human0.63408832
66AR_20517297_ChIP-Seq_VCAP_Human0.62640815
67RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62401833
68CDX2_20551321_ChIP-Seq_CACO-2_Human0.62244978
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.62086429
70FOXA1_25552417_ChIP-Seq_VCAP_Human0.61969380
71CSB_26484114_Chip-Seq_FIBROBLAST_Human0.61728026
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.61150498
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61117163
74CEBPB_22108803_ChIP-Seq_LS180_Human0.60196128
75EGR1_19032775_ChIP-ChIP_M12_Human0.59126912
76RARB_24833708_ChIP-Seq_LIVER_Mouse0.58615626
77TRIM28_21343339_ChIP-Seq_HEK293_Human0.58528359
78ETV2_25802403_ChIP-Seq_MESCs_Mouse0.58370026
79SOX2_20726797_ChIP-Seq_SW620_Human0.57705946
80TP63_17297297_ChIP-ChIP_HaCaT_Human0.55477360
81PIAS1_25552417_ChIP-Seq_VCAP_Human0.54969415
82PHF8_20622853_ChIP-Seq_HELA_Human0.53925730
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.53779511
84ERA_21632823_ChIP-Seq_H3396_Human0.53588862
85CTCF_27219007_Chip-Seq_Bcells_Human0.52658832
86BCAT_22108803_ChIP-Seq_LS180_Human0.52636722
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52487373
88LXR_22292898_ChIP-Seq_THP-1_Human0.52019550
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.51491974
90ZNF263_19887448_ChIP-Seq_K562_Human0.51272303
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.50982261
92SPI1_20517297_ChIP-Seq_HL60_Human0.50923875
93NANOG_20526341_ChIP-Seq_ESCs_Human0.50530778
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.50502569
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.50223623
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.49967858
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.49785668
98P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.49657804
99ESET_19884257_ChIP-Seq_ESCs_Mouse0.49513881
100FOXO3_23340844_ChIP-Seq_DLD1_Human0.49348246
101E2F1_20622854_ChIP-Seq_HELA_Human0.48628514
102P53_21459846_ChIP-Seq_SAOS-2_Human0.47608046
103STAT1_17558387_ChIP-Seq_HELA_Human0.47407022
104CBP_21632823_ChIP-Seq_H3396_Human0.47291463
105MYC_19915707_ChIP-ChIP_AK7_Human0.47112465
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47014625
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46341148
108GATA6_25053715_ChIP-Seq_YYC3_Human0.46079600
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.43920564
110PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43524490
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.42970017
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42316723
113* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41144227
114TAF2_19829295_ChIP-Seq_ESCs_Human0.40750341
115GATA3_24758297_ChIP-Seq_MCF-7_Human0.40594976
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.40022973
117GATA1_19941826_ChIP-Seq_K562_Human0.39580583
118ERG_21242973_ChIP-ChIP_JURKAT_Human0.39345015
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38885557
120STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38613259
121GATA2_19941826_ChIP-Seq_K562_Human0.37884229
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.37864863
123FOXH1_21741376_ChIP-Seq_EPCs_Human0.37607848
124P63_26484246_Chip-Seq_KERATINOCYTES_Human0.37606927
125PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.37219777
126CDX2_22108803_ChIP-Seq_LS180_Human0.37169329
127EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.36987441
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.36703573
129MYC_27129775_Chip-Seq_CORNEA_Mouse0.36680644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.05929492
2MP0005360_urolithiasis7.22917186
3MP0005085_abnormal_gallbladder_physiolo6.42384044
4MP0005365_abnormal_bile_salt6.31420827
5MP0008875_abnormal_xenobiotic_pharmacok4.94343471
6MP0003806_abnormal_nucleotide_metabolis3.90276707
7MP0003252_abnormal_bile_duct3.78945087
8MP0010329_abnormal_lipoprotein_level3.43605857
9MP0005083_abnormal_biliary_tract3.30835848
10MP0009840_abnormal_foam_cell3.25776784
11MP0003195_calcinosis2.99849426
12MP0001666_abnormal_nutrient_absorption2.93500773
13MP0005332_abnormal_amino_acid2.68216829
14MP0003191_abnormal_cellular_cholesterol2.55216753
15MP0004019_abnormal_vitamin_homeostasis2.10143684
16MP0000609_abnormal_liver_physiology2.08210283
17MP0002118_abnormal_lipid_homeostasis2.07050889
18MP0003868_abnormal_feces_composition1.98003377
19MP0002138_abnormal_hepatobiliary_system1.96696828
20MP0005319_abnormal_enzyme/_coenzyme1.72760791
21MP0001764_abnormal_homeostasis1.67687246
22MP0002132_abnormal_respiratory_system1.48786382
23MP0009697_abnormal_copulation1.44483162
24MP0005584_abnormal_enzyme/coenzyme_acti1.43363869
25MP0005451_abnormal_body_composition1.37834222
26MP0009643_abnormal_urine_homeostasis1.32038680
27MP0003011_delayed_dark_adaptation1.25285883
28MP0003186_abnormal_redox_activity1.18858507
29MP0002254_reproductive_system_inflammat1.18775264
30MP0003705_abnormal_hypodermis_morpholog1.14897575
31MP0005647_abnormal_sex_gland1.10838055
32MP0005220_abnormal_exocrine_pancreas1.10807592
33MP0000598_abnormal_liver_morphology1.10161601
34MP0009764_decreased_sensitivity_to1.09820716
35MP0010368_abnormal_lymphatic_system1.07331871
36MP0003656_abnormal_erythrocyte_physiolo1.06066634
37MP0009763_increased_sensitivity_to1.02804451
38MP0005084_abnormal_gallbladder_morpholo1.01460107
39MP0000604_amyloidosis0.99902498
40MP0005636_abnormal_mineral_homeostasis0.99776832
41MP0005408_hypopigmentation0.96744111
42MP0008469_abnormal_protein_level0.94776221
43MP0009642_abnormal_blood_homeostasis0.88951358
44MP0001915_intracranial_hemorrhage0.88480725
45MP0005670_abnormal_white_adipose0.83626307
46MP0003879_abnormal_hair_cell0.83288353
47MP0002078_abnormal_glucose_homeostasis0.81856687
48MP0009765_abnormal_xenobiotic_induced0.80981996
49MP0005376_homeostasis/metabolism_phenot0.74101169
50MP0002876_abnormal_thyroid_physiology0.73170419
51MP0003122_maternal_imprinting0.71974791
52MP0004272_abnormal_basement_membrane0.71754136
53MP0009053_abnormal_anal_canal0.70095212
54MP0001756_abnormal_urination0.68781908
55MP0002971_abnormal_brown_adipose0.68595786
56MP0005334_abnormal_fat_pad0.68200040
57MP0006036_abnormal_mitochondrial_physio0.67278499
58MP0003690_abnormal_glial_cell0.67190320
59MP0000566_synostosis0.66955590
60MP0005535_abnormal_body_temperature0.65471958
61MP0002282_abnormal_trachea_morphology0.64514334
62MP0000639_abnormal_adrenal_gland0.63955392
63MP0009780_abnormal_chondrocyte_physiolo0.62969532
64MP0003724_increased_susceptibility_to0.62259790
65MP0002796_impaired_skin_barrier0.61883544
66MP0005464_abnormal_platelet_physiology0.61755240
67MP0003638_abnormal_response/metabolism_0.61618591
68MP0003172_abnormal_lysosome_physiology0.59814971
69MP0005448_abnormal_energy_balance0.59561061
70MP0001661_extended_life_span0.57948535
71MP0003436_decreased_susceptibility_to0.56866840
72MP0005187_abnormal_penis_morphology0.56821257
73MP0004381_abnormal_hair_follicle0.56490784
74MP0004782_abnormal_surfactant_physiolog0.56234092
75MP0004130_abnormal_muscle_cell0.51779549
76MP0002060_abnormal_skin_morphology0.50734347
77MP0002928_abnormal_bile_duct0.50642214
78MP0005266_abnormal_metabolism0.50508759
79MP0002136_abnormal_kidney_physiology0.49975382
80MP0002089_abnormal_postnatal_growth/wei0.49945123
81MP0005023_abnormal_wound_healing0.49238876
82MP0009384_cardiac_valve_regurgitation0.47477847
83MP0002909_abnormal_adrenal_gland0.47399891
84MP0000579_abnormal_nail_morphology0.46378575
85MP0005395_other_phenotype0.45896436
86MP0003953_abnormal_hormone_level0.45164755
87MP0008872_abnormal_physiological_respon0.45094462
88MP0009785_altered_susceptibility_to0.44939113
89MP0005058_abnormal_lysosome_morphology0.44050601
90MP0003329_amyloid_beta_deposits0.43284915
91MP0001944_abnormal_pancreas_morphology0.42276862
92MP0008873_increased_physiological_sensi0.42177477
93MP0009115_abnormal_fat_cell0.41717394
94MP0001243_abnormal_dermal_layer0.41414390
95MP0008874_decreased_physiological_sensi0.40125797
96MP0003075_altered_response_to0.38420802
97MP0002822_catalepsy0.37950052
98MP0002295_abnormal_pulmonary_circulatio0.37471461
99MP0005379_endocrine/exocrine_gland_phen0.37230929
100MP0001845_abnormal_inflammatory_respons0.37222968
101MP0010386_abnormal_urinary_bladder0.37134204
102MP0002837_dystrophic_cardiac_calcinosis0.36875475
103MP0002249_abnormal_larynx_morphology0.36039864
104MP0005166_decreased_susceptibility_to0.36000782
105MP0005409_darkened_coat_color0.35431353
106MP0006035_abnormal_mitochondrial_morpho0.35101051
107MP0003718_maternal_effect0.34844041
108MP0006082_CNS_inflammation0.34747366
109MP0004264_abnormal_extraembryonic_tissu0.33455695
110MP0000230_abnormal_systemic_arterial0.33057128
111MP0002168_other_aberrant_phenotype0.32360825
112MP0005167_abnormal_blood-brain_barrier0.32020534
113MP0003453_abnormal_keratinocyte_physiol0.31816353
114MP0000249_abnormal_blood_vessel0.31575743
115MP0009379_abnormal_foot_pigmentation0.31445044
116MP0004883_abnormal_blood_vessel0.31309344
117MP0005666_abnormal_adipose_tissue0.30982105
118MP0002090_abnormal_vision0.30921005
119MP0001853_heart_inflammation0.29483214
120MP0002693_abnormal_pancreas_physiology0.29230830
121MP0001881_abnormal_mammary_gland0.29213262
122MP0005164_abnormal_response_to0.29115492
123MP0005410_abnormal_fertilization0.26702494
124MP0002970_abnormal_white_adipose0.26244979
125MP0000920_abnormal_myelination0.24903327

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.54325161
2Deep venous thrombosis (HP:0002625)7.21175949
3Intrahepatic cholestasis (HP:0001406)7.16782182
4Prolonged partial thromboplastin time (HP:0003645)6.70342700
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.68459720
6Hypobetalipoproteinemia (HP:0003563)6.14138202
7Xanthomatosis (HP:0000991)6.10950631
8Complement deficiency (HP:0004431)5.70435420
9Hyperlipoproteinemia (HP:0010980)5.48020181
10Joint hemorrhage (HP:0005261)4.88360646
11Abnormality of the common coagulation pathway (HP:0010990)4.82638486
12Hypolipoproteinemia (HP:0010981)4.67885262
13Hyperammonemia (HP:0001987)4.43605667
14Epidermoid cyst (HP:0200040)4.30091072
15Abnormality of methionine metabolism (HP:0010901)4.29645758
16Ketosis (HP:0001946)4.29301412
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.27933991
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.26805289
19Fat malabsorption (HP:0002630)4.25192219
20Abnormality of complement system (HP:0005339)4.20566364
21Hyperglycinemia (HP:0002154)4.18255619
22Hypoalphalipoproteinemia (HP:0003233)4.17510599
23Hypoglycemic coma (HP:0001325)4.11293966
24Abnormality of the intrinsic pathway (HP:0010989)4.10146861
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09041911
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.99715425
27Conjugated hyperbilirubinemia (HP:0002908)3.82465274
28Hyperglycinuria (HP:0003108)3.74080500
29Abnormality of pyrimidine metabolism (HP:0004353)3.74061670
30Abnormality of serine family amino acid metabolism (HP:0010894)3.66836272
31Abnormality of glycine metabolism (HP:0010895)3.66836272
32Hypercholesterolemia (HP:0003124)3.51622177
33Steatorrhea (HP:0002570)3.31076313
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30281940
35Hyperbilirubinemia (HP:0002904)3.26811556
36Abnormality of fatty-acid metabolism (HP:0004359)3.26143898
37Spontaneous abortion (HP:0005268)3.24741695
38Ketoacidosis (HP:0001993)3.22530054
39Systemic lupus erythematosus (HP:0002725)3.15087623
40Abnormality of nucleobase metabolism (HP:0010932)3.02470735
41Myocardial infarction (HP:0001658)3.01268764
42Glomerulonephritis (HP:0000099)3.01130876
43Delayed CNS myelination (HP:0002188)2.96318695
44Abnormality of serum amino acid levels (HP:0003112)2.90642239
45Hypoglycemic seizures (HP:0002173)2.85246918
46Hepatocellular carcinoma (HP:0001402)2.79498248
47Purpura (HP:0000979)2.74004221
48Skin nodule (HP:0200036)2.69324275
49Metabolic acidosis (HP:0001942)2.67362266
50Abnormality of purine metabolism (HP:0004352)2.66675268
51Vascular calcification (HP:0004934)2.65893169
52Amyloidosis (HP:0011034)2.65519210
53Hypochromic microcytic anemia (HP:0004840)2.63666904
54Lethargy (HP:0001254)2.55137991
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50935211
56Dicarboxylic aciduria (HP:0003215)2.50935211
57Late onset (HP:0003584)2.48272823
58Gout (HP:0001997)2.47328144
59Recurrent gram-negative bacterial infections (HP:0005420)2.46136160
60Osteomalacia (HP:0002749)2.45371609
61Mitral stenosis (HP:0001718)2.43870254
62Gingival bleeding (HP:0000225)2.41504232
63Hyperinsulinemic hypoglycemia (HP:0000825)2.40082212
64Cerebral edema (HP:0002181)2.39898413
65Reduced antithrombin III activity (HP:0001976)2.37943864
66Cardiovascular calcification (HP:0011915)2.35856547
67Irritability (HP:0000737)2.34926117
68Abnormal gallbladder morphology (HP:0012437)2.29079979
69Menorrhagia (HP:0000132)2.27024591
70Spastic diplegia (HP:0001264)2.25580577
71Pancreatitis (HP:0001733)2.23602637
72Neonatal onset (HP:0003623)2.23589722
73Acanthocytosis (HP:0001927)2.21065795
74Pulmonary embolism (HP:0002204)2.16991473
75Generalized aminoaciduria (HP:0002909)2.16303214
76Cholelithiasis (HP:0001081)2.15234797
77Malnutrition (HP:0004395)2.12593383
78Hyperglycemia (HP:0003074)2.12483312
79Thrombophlebitis (HP:0004418)2.11624856
80Esophageal varix (HP:0002040)2.10546332
81Arthropathy (HP:0003040)2.10115579
82Fair hair (HP:0002286)2.09714438
83Enlarged kidneys (HP:0000105)2.08851202
84Opisthotonus (HP:0002179)2.08823168
85Brushfield spots (HP:0001088)2.08141844
86Abnormality of urine glucose concentration (HP:0011016)2.07446765
87Glycosuria (HP:0003076)2.07446765
88Nephritis (HP:0000123)2.05678449
89Vomiting (HP:0002013)2.04377697
90Symptomatic seizures (HP:0011145)2.02886655
91Abnormality of iron homeostasis (HP:0011031)2.02268992
92Abnormality of transition element cation homeostasis (HP:0011030)2.00974934
93Sensorimotor neuropathy (HP:0007141)1.99366849
94Abnormality of the Achilles tendon (HP:0005109)1.96882459
95Hyperphosphaturia (HP:0003109)1.92906493
96Rickets (HP:0002748)1.92381381
97Abnormal gallbladder physiology (HP:0012438)1.89970801
98Cholecystitis (HP:0001082)1.89970801
99Hypophosphatemic rickets (HP:0004912)1.89779775
100Bifid scrotum (HP:0000048)1.87663157
101Hemorrhage of the eye (HP:0011885)1.86328705
102Abnormality of the gallbladder (HP:0005264)1.85119590
103Alkalosis (HP:0001948)1.84543249
104Abnormal enzyme/coenzyme activity (HP:0012379)1.81882600
105Renal cortical cysts (HP:0000803)1.80854015
106Joint swelling (HP:0001386)1.79826502
107Abnormality of vitamin metabolism (HP:0100508)1.78287654
108Poikilocytosis (HP:0004447)1.77960647
109Elevated hepatic transaminases (HP:0002910)1.77874204
110Retinal atrophy (HP:0001105)1.76489017
111Neonatal hypoglycemia (HP:0001998)1.76319087
112Abnormal cartilage morphology (HP:0002763)1.75885838
113Hydroxyprolinuria (HP:0003080)1.75099360
114Abnormality of proline metabolism (HP:0010907)1.75099360
115Increased serum ferritin (HP:0003281)1.72649380
116Abnormal tarsal ossification (HP:0008369)1.72508698
117Epistaxis (HP:0000421)1.67480261
118Elevated alkaline phosphatase (HP:0003155)1.66148628
119Increased serum pyruvate (HP:0003542)1.64855925
120Gangrene (HP:0100758)1.61925817
121Abnormality of alkaline phosphatase activity (HP:0004379)1.60696081
122Proximal tubulopathy (HP:0000114)1.59972246
123Potter facies (HP:0002009)1.58657766
124Facial shape deformation (HP:0011334)1.58657766
125Abnormal urine phosphate concentration (HP:0012599)1.58007356
126Abnormal delivery (HP:0001787)1.57573288
127Mucopolysacchariduria (HP:0008155)1.57183463
128Urinary glycosaminoglycan excretion (HP:0003541)1.57183463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.73672407
2ERN14.87486296
3FGFR44.21705477
4SIK13.80553540
5INSRR3.63244936
6TAOK33.41211376
7MST1R2.53469436
8ERBB42.47356506
9PIK3CG2.31109849
10MAPK152.21345711
11PDK22.17775645
12MYLK2.13873904
13FLT31.85638724
14FRK1.84328162
15TYK21.79438940
16PKN21.75133215
17MAP2K41.74931828
18MAPK111.67980851
19TRIB31.58137732
20AKT31.55117131
21ICK1.53370445
22WNK41.53042954
23PTK61.52912868
24DAPK21.49277751
25LATS11.44297082
26MAP3K31.43981379
27NEK91.42237962
28IRAK31.32894758
29JAK21.25726266
30TGFBR21.17620876
31ABL21.17377191
32EPHA21.16628661
33TBK11.15910836
34EPHA31.15085552
35FGFR21.14901082
36MAP3K141.12519962
37PRKAA21.02175489
38JAK11.01899473
39ARAF1.00126818
40FGFR10.99750715
41MET0.99658025
42SGK4940.99247670
43SGK2230.99247670
44KDR0.95454205
45EPHB10.94035383
46NTRK30.93088154
47CDC42BPA0.89696716
48ERBB20.89491524
49MAP2K30.88704939
50MAP3K20.88020695
51ACVR1B0.85046930
52DYRK1B0.85033828
53STK38L0.83988277
54MAPK40.82862055
55MAPK120.81350208
56PRKG20.81111573
57EEF2K0.80120658
58PRKCZ0.79687071
59MAP2K20.79488709
60MAP3K120.79005695
61MAP3K70.76813350
62DDR20.76265511
63IKBKE0.75746223
64MAP2K60.74941327
65CSK0.73179081
66PRKG10.71015113
67PRKACG0.69869393
68PDGFRA0.68982121
69PINK10.67760561
70TIE10.67726147
71CDK60.67719233
72GSK3A0.67035597
73MARK30.66439115
74EIF2AK30.66019548
75MUSK0.64930527
76GRK10.63052124
77MAPK70.62741260
78MAP2K10.62494519
79IRAK10.62134561
80STK380.60627282
81MAP3K100.59923595
82CAMK2G0.59764107
83GRK60.59231597
84BRSK20.58037149
85PTK20.57751859
86NEK20.56914125
87FGFR30.55086579
88IGF1R0.54769539
89AKT20.52263156
90PRKAA10.51949550
91IRAK20.51235772
92CAMK1D0.49934209
93PIK3CA0.49892851
94MAP3K110.49501034
95TNK20.48075946
96RIPK10.47776970
97RPS6KB10.47705812
98CSF1R0.46010001
99PDPK10.45067100
100CSNK1D0.44780947
101SGK10.41802223
102LMTK20.41712161
103GRK70.41613913
104MAP3K10.40793988
105CAMKK20.40691112
106OBSCN0.39981613
107EPHB20.38424525
108MAPKAPK30.37571103
109PRKCQ0.37223851
110SGK30.37088913
111PRKACB0.36452204
112ZAP700.35729761
113SRC0.35388112
114RET0.35238548
115STK160.35044882
116ITK0.35037262
117PRKCE0.34903157
118TRPM70.34848415
119CSNK2A10.34557861
120CSNK1A10.33721550
121MAP3K90.33319435
122CSNK1E0.33290951
123LATS20.33097690
124EGFR0.32986093
125FER0.31365967
126SGK20.29097119
127CAMK40.28434333
128MAP3K50.27823869
129PKN10.27433833
130MAPK30.27005042
131PRKCG0.26971951
132PRKCA0.26700275
133CSNK1G10.26168270
134IKBKB0.25748607
135TAOK20.25280313
136MTOR0.25112339
137PDK10.23500868
138PAK30.23454791
139ABL10.22974179
140CHUK0.21895120
141PRKACA0.18576743
142BLK0.18378681
143NLK0.18179852

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.57452868
2Nitrogen metabolism_Homo sapiens_hsa009103.35466306
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32289737
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29062518
5Arginine biosynthesis_Homo sapiens_hsa002203.01616614
6Complement and coagulation cascades_Homo sapiens_hsa046102.91563598
7Tryptophan metabolism_Homo sapiens_hsa003802.67895849
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53589453
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48101646
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46505781
11Fatty acid degradation_Homo sapiens_hsa000712.39601304
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35998392
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.29082075
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26420233
15Chemical carcinogenesis_Homo sapiens_hsa052042.07214670
16Peroxisome_Homo sapiens_hsa041462.05920889
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.04085045
18Butanoate metabolism_Homo sapiens_hsa006502.01909053
19Histidine metabolism_Homo sapiens_hsa003401.95339502
20Staphylococcus aureus infection_Homo sapiens_hsa051501.95095444
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.91076441
22Propanoate metabolism_Homo sapiens_hsa006401.82173351
23PPAR signaling pathway_Homo sapiens_hsa033201.81292150
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.76397886
25Caffeine metabolism_Homo sapiens_hsa002321.76395979
26Retinol metabolism_Homo sapiens_hsa008301.68450588
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68182850
28beta-Alanine metabolism_Homo sapiens_hsa004101.68020238
29Fatty acid metabolism_Homo sapiens_hsa012121.66399605
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64200086
31Phenylalanine metabolism_Homo sapiens_hsa003601.63922487
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63236042
33Selenocompound metabolism_Homo sapiens_hsa004501.60605081
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.50224783
35Sulfur metabolism_Homo sapiens_hsa009201.48922856
36Tyrosine metabolism_Homo sapiens_hsa003501.47471680
37Bile secretion_Homo sapiens_hsa049761.44177604
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43443029
39Folate biosynthesis_Homo sapiens_hsa007901.40774684
40Fat digestion and absorption_Homo sapiens_hsa049751.39440438
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31257928
42Starch and sucrose metabolism_Homo sapiens_hsa005001.31046979
43Fatty acid elongation_Homo sapiens_hsa000621.24239214
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.24083135
45ABC transporters_Homo sapiens_hsa020101.23357365
46Pyruvate metabolism_Homo sapiens_hsa006201.21157887
47Steroid biosynthesis_Homo sapiens_hsa001001.20671345
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16222525
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.13571183
50Biosynthesis of amino acids_Homo sapiens_hsa012301.07979009
51Arginine and proline metabolism_Homo sapiens_hsa003300.99188350
52Carbon metabolism_Homo sapiens_hsa012000.96755547
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95256185
54Vitamin digestion and absorption_Homo sapiens_hsa049770.93509320
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90602853
56Sulfur relay system_Homo sapiens_hsa041220.89278033
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76896649
58Glutathione metabolism_Homo sapiens_hsa004800.74865866
59Lysine degradation_Homo sapiens_hsa003100.73093280
60Vitamin B6 metabolism_Homo sapiens_hsa007500.70095398
61Glycerolipid metabolism_Homo sapiens_hsa005610.68194947
62One carbon pool by folate_Homo sapiens_hsa006700.64661808
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62043486
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59522804
65Other glycan degradation_Homo sapiens_hsa005110.51706276
66Pentose phosphate pathway_Homo sapiens_hsa000300.48362605
67Metabolic pathways_Homo sapiens_hsa011000.46891311
68Prion diseases_Homo sapiens_hsa050200.42139742
69Fatty acid biosynthesis_Homo sapiens_hsa000610.35598151
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34811380
71Linoleic acid metabolism_Homo sapiens_hsa005910.34705146
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31849199
73Galactose metabolism_Homo sapiens_hsa000520.26666563
74Mineral absorption_Homo sapiens_hsa049780.26281416
75Fructose and mannose metabolism_Homo sapiens_hsa000510.24113610
76Insulin resistance_Homo sapiens_hsa049310.23764585
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.19003697
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.15193532
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09872899
80Systemic lupus erythematosus_Homo sapiens_hsa053220.09320721
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08866992
82Glucagon signaling pathway_Homo sapiens_hsa049220.08430680
83Sphingolipid metabolism_Homo sapiens_hsa006000.07033354
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.01990267
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01169755
86N-Glycan biosynthesis_Homo sapiens_hsa005100.01102784
87Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1675183
88Pancreatic secretion_Homo sapiens_hsa04972-0.1671148
89Ether lipid metabolism_Homo sapiens_hsa00565-0.1618459
90African trypanosomiasis_Homo sapiens_hsa05143-0.1517510
91Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1511808
92Pertussis_Homo sapiens_hsa05133-0.1482549
93Serotonergic synapse_Homo sapiens_hsa04726-0.1435587
94Hepatitis C_Homo sapiens_hsa05160-0.1374871
95Lysosome_Homo sapiens_hsa04142-0.1369307
96Insulin signaling pathway_Homo sapiens_hsa04910-0.1346187
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1264973
98Protein digestion and absorption_Homo sapiens_hsa04974-0.0999709
99Regulation of autophagy_Homo sapiens_hsa04140-0.0945555
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0934684
101Renin-angiotensin system_Homo sapiens_hsa04614-0.0877047
102Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0785794
103Circadian rhythm_Homo sapiens_hsa04710-0.0773848
104Protein export_Homo sapiens_hsa03060-0.0441016
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0379697
106Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0262862
107AMPK signaling pathway_Homo sapiens_hsa04152-0.0200653
108Amoebiasis_Homo sapiens_hsa05146-0.0157755

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