ANGEL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.99907911
2sperm-egg recognition (GO:0035036)9.26562785
3multicellular organism reproduction (GO:0032504)8.75791221
4binding of sperm to zona pellucida (GO:0007339)8.66676140
5axonemal dynein complex assembly (GO:0070286)8.65529637
6plasma membrane fusion (GO:0045026)8.54016182
7male meiosis (GO:0007140)8.31949717
8acrosome assembly (GO:0001675)8.27782520
9cell-cell recognition (GO:0009988)8.23169759
10epithelial cilium movement (GO:0003351)8.16711702
11spermatid development (GO:0007286)8.11179078
12synaptonemal complex organization (GO:0070193)7.88169426
13motile cilium assembly (GO:0044458)7.60950027
14synaptonemal complex assembly (GO:0007130)7.59818353
15regulation of cilium movement (GO:0003352)7.39325146
16cell wall macromolecule metabolic process (GO:0044036)7.37325715
17cell wall macromolecule catabolic process (GO:0016998)7.37325715
18reproduction (GO:0000003)7.24539585
19cilium movement (GO:0003341)6.76483375
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.71432800
21DNA methylation involved in gamete generation (GO:0043046)6.62296094
22male meiosis I (GO:0007141)6.02882904
23single fertilization (GO:0007338)6.01034378
24negative regulation of inclusion body assembly (GO:0090084)5.96788799
25sperm capacitation (GO:0048240)5.72751857
26spermatogenesis (GO:0007283)5.48309555
27fertilization (GO:0009566)5.47476974
28male gamete generation (GO:0048232)5.47081895
29meiotic nuclear division (GO:0007126)5.24098644
30gamete generation (GO:0007276)5.10150585
31regulation of inclusion body assembly (GO:0090083)5.08931416
32meiosis I (GO:0007127)5.04147910
33germ cell development (GO:0007281)5.01955846
34chromosome organization involved in meiosis (GO:0070192)4.93621768
35regulation of microtubule-based movement (GO:0060632)4.90482388
36cellular process involved in reproduction in multicellular organism (GO:0022412)4.86734263
37histone H3-K36 demethylation (GO:0070544)4.85803889
38calcium ion-dependent exocytosis (GO:0017156)4.80168863
39microtubule depolymerization (GO:0007019)4.73044352
40protein polyglutamylation (GO:0018095)4.71417093
41regulation of meiosis I (GO:0060631)4.59315359
42proline biosynthetic process (GO:0006561)4.58907764
43meiotic cell cycle (GO:0051321)4.47465567
44gene silencing by RNA (GO:0031047)4.43813743
45seminiferous tubule development (GO:0072520)4.42631888
46organic cation transport (GO:0015695)4.40081903
47microtubule severing (GO:0051013)4.37641621
48proline metabolic process (GO:0006560)4.30120410
49left/right pattern formation (GO:0060972)4.20797462
50negative regulation of organelle assembly (GO:1902116)4.19756532
51positive regulation by host of viral transcription (GO:0043923)4.15997256
52ventricular system development (GO:0021591)4.12190441
53dicarboxylic acid biosynthetic process (GO:0043650)3.97875094
54multicellular organismal reproductive process (GO:0048609)3.97723206
55cell recognition (GO:0008037)3.84738473
56monoubiquitinated protein deubiquitination (GO:0035520)3.80844879
57L-alpha-amino acid transmembrane transport (GO:1902475)3.76627963
58histone H3-K9 demethylation (GO:0033169)3.75803087
59cell volume homeostasis (GO:0006884)3.72126190
60protein localization to cilium (GO:0061512)3.66890972
61peptidyl-lysine dimethylation (GO:0018027)3.60981641
62chaperone-mediated protein complex assembly (GO:0051131)3.58909782
63negative regulation of erythrocyte differentiation (GO:0045647)3.54363081
64epithelial cell fate commitment (GO:0072148)3.52781832
65biotin metabolic process (GO:0006768)3.52549334
66meiotic cell cycle process (GO:1903046)3.48132298
67carnitine transmembrane transport (GO:1902603)3.41410533
68amino-acid betaine transport (GO:0015838)3.39218082
69carnitine transport (GO:0015879)3.39218082
70protein-DNA complex disassembly (GO:0032986)3.38240135
71nucleosome disassembly (GO:0006337)3.38240135
72gene silencing (GO:0016458)3.34085835
73genitalia morphogenesis (GO:0035112)3.33355017
74glutamine family amino acid biosynthetic process (GO:0009084)3.31827965
75intracellular estrogen receptor signaling pathway (GO:0030520)3.31287431
76nuclear pore complex assembly (GO:0051292)3.30889421
77regulation of spindle checkpoint (GO:0090231)3.29895379
78histone lysine demethylation (GO:0070076)3.27604950
79protein refolding (GO:0042026)3.26416465
80carnitine shuttle (GO:0006853)3.24051688
81axoneme assembly (GO:0035082)3.22710213
82regulation of centriole replication (GO:0046599)3.19574695
83multicellular organismal development (GO:0007275)3.19195254
84RNA localization (GO:0006403)3.16573437
85chromosome condensation (GO:0030261)3.13778008
86negative regulation of cell size (GO:0045792)3.13004944
87microtubule-based movement (GO:0007018)3.13002038
88cell-cell junction maintenance (GO:0045217)3.07708344
89intraciliary transport (GO:0042073)3.07492841
90DNA packaging (GO:0006323)3.07264174
91mitotic sister chromatid cohesion (GO:0007064)3.06664600
92DNA alkylation (GO:0006305)3.05165994
93DNA methylation (GO:0006306)3.05165994
94regulation of histone H3-K4 methylation (GO:0051569)3.04762900
95DNA unwinding involved in DNA replication (GO:0006268)3.03124470
96histone demethylation (GO:0016577)3.02263043
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.02031346
98L-phenylalanine catabolic process (GO:0006559)3.02031346
99regulation of ARF protein signal transduction (GO:0032012)3.02001643
100positive regulation of Rap GTPase activity (GO:0032854)3.01736360
101mannose metabolic process (GO:0006013)3.00304019
102establishment of protein localization to Golgi (GO:0072600)2.96216899
103sex differentiation (GO:0007548)2.94247649
104L-phenylalanine metabolic process (GO:0006558)2.93284066
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.93284066
106nucleus organization (GO:0006997)2.89923158
107lactate metabolic process (GO:0006089)2.88852620
108regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.86868381
109negative regulation of gene expression, epigenetic (GO:0045814)2.85909288
110embryonic camera-type eye morphogenesis (GO:0048596)2.85510897
111pre-miRNA processing (GO:0031054)2.84848447
112polyol catabolic process (GO:0046174)2.83939141
113response to parathyroid hormone (GO:0071107)2.82805718
114sodium ion export (GO:0071436)2.82563142
115protein complex localization (GO:0031503)2.81282658
116peptidyl-glutamic acid modification (GO:0018200)2.81034393
117glycerol ether metabolic process (GO:0006662)2.79860468
118oocyte development (GO:0048599)2.79330165
119regulation of cholesterol metabolic process (GO:0090181)2.78569261
120regulation of cilium assembly (GO:1902017)2.78099476
121nuclear pore organization (GO:0006999)2.77979118
122regulation of cholesterol biosynthetic process (GO:0045540)2.75665370
123positive regulation of gene expression, epigenetic (GO:0045815)2.74528886
124glutamate metabolic process (GO:0006536)2.74383678
125regulation of chromatin binding (GO:0035561)2.73538957
126spermatid nucleus differentiation (GO:0007289)2.72683523
127regulation of translational fidelity (GO:0006450)2.71122005
128response to acidic pH (GO:0010447)2.71011507
129positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.70877290
130amino acid import (GO:0043090)2.69210620
131cilium morphogenesis (GO:0060271)2.68911092
132peptidyl-arginine omega-N-methylation (GO:0035247)2.68877278
133poly(A)+ mRNA export from nucleus (GO:0016973)2.67699214
134regulation of gamma-delta T cell differentiation (GO:0045586)2.67324553
135glycolytic process (GO:0006096)2.66952878
136glycosphingolipid catabolic process (GO:0046479)2.65290749
137positive regulation of gluconeogenesis (GO:0045722)2.65138622
138L-amino acid import (GO:0043092)2.64876353
139neurotransmitter-gated ion channel clustering (GO:0072578)2.63867175
140histone H4-K5 acetylation (GO:0043981)2.63862227
141histone H4-K8 acetylation (GO:0043982)2.63862227
142microtubule polymerization or depolymerization (GO:0031109)2.61312124
143glycolipid catabolic process (GO:0019377)2.60718232
144cellular hyperosmotic response (GO:0071474)2.60685953
145rRNA transcription (GO:0009303)2.58627487
146apoptotic process involved in morphogenesis (GO:0060561)2.58455190
147histone H4 deacetylation (GO:0070933)2.58082478
148regulation of histone H3-K9 methylation (GO:0051570)2.57887618
149ether metabolic process (GO:0018904)2.56243549
150fatty acid homeostasis (GO:0055089)2.56148413
151regulation of histone H3-K27 methylation (GO:0061085)2.56115553
152fatty acid transmembrane transport (GO:1902001)2.55766438
153protein K11-linked deubiquitination (GO:0035871)2.55119988
154Golgi to endosome transport (GO:0006895)2.55029437
155protein dealkylation (GO:0008214)2.54409311
156protein demethylation (GO:0006482)2.54409311
157chromatin silencing (GO:0006342)2.54347393
158modulation by virus of host morphology or physiology (GO:0019048)2.54285537
159regulation of Rap GTPase activity (GO:0032317)2.52031923
160membrane depolarization during action potential (GO:0086010)2.51266303
161interferon-gamma secretion (GO:0072643)2.51226049
162spliceosomal tri-snRNP complex assembly (GO:0000244)2.51102974
163cytoplasmic microtubule organization (GO:0031122)2.50260862
164post-embryonic morphogenesis (GO:0009886)2.49913912
165pentose metabolic process (GO:0019321)2.49285350
166histone H3-K9 methylation (GO:0051567)2.46899240
167histone H3-K9 modification (GO:0061647)2.45847673
168neuromuscular process controlling balance (GO:0050885)2.41329374
169glutamine family amino acid catabolic process (GO:0009065)2.39667861
170retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39483795
171phospholipid dephosphorylation (GO:0046839)2.39364712
172negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.38842775
173negative regulation of histone methylation (GO:0031061)2.38650474
174snRNA metabolic process (GO:0016073)2.38273007
175mating behavior (GO:0007617)2.35433893
176cell junction maintenance (GO:0034331)2.34498105
177urea cycle (GO:0000050)2.33220101
178cellular response to thyroid hormone stimulus (GO:0097067)2.31634086
179regulation of monocyte differentiation (GO:0045655)2.31598036
180embryonic eye morphogenesis (GO:0048048)2.31239423
181regulation of NFAT protein import into nucleus (GO:0051532)2.31004481
182histone H3-K4 methylation (GO:0051568)2.30783959
183positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.30577746
184mRNA cleavage (GO:0006379)2.29991739
185phosphatidylinositol dephosphorylation (GO:0046856)2.27807497
186N-acetylneuraminate metabolic process (GO:0006054)2.27796427
187TOR signaling (GO:0031929)2.27691811
188urea metabolic process (GO:0019627)2.26638470
189epithelial cell differentiation involved in prostate gland development (GO:0060742)2.26372409
190response to thyroid hormone (GO:0097066)2.26004171
191sterol catabolic process (GO:0016127)2.25979182
192cholesterol catabolic process (GO:0006707)2.25979182
193fusion of sperm to egg plasma membrane (GO:0007342)11.1652009
194cilium or flagellum-dependent cell motility (GO:0001539)10.6416757
195piRNA metabolic process (GO:0034587)10.4803987
196sperm motility (GO:0030317)10.3943743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.54251118
2MYC_22102868_ChIP-Seq_BL_Human3.53442135
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.46499329
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.08097915
5E2F7_22180533_ChIP-Seq_HELA_Human3.00220759
6* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.86498705
7LXR_22292898_ChIP-Seq_THP-1_Human2.61679657
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.55040955
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50707502
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.41430646
11VDR_21846776_ChIP-Seq_THP-1_Human2.34817564
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27926717
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.24741602
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21702474
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15568234
16TCF7_22412390_ChIP-Seq_EML_Mouse2.15367426
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.09418200
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.08960343
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.05398881
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04154029
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00581237
22KDM2B_26808549_Chip-Seq_DND41_Human2.00008915
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.8649625
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.98846345
25RACK7_27058665_Chip-Seq_MCF-7_Human1.97046189
26KDM2B_26808549_Chip-Seq_K562_Human1.91652858
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.89113999
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88632472
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76984662
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.76597751
31ZNF274_21170338_ChIP-Seq_K562_Hela1.73738655
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.69695796
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69081048
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.68495010
35* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65695684
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64063745
37ZNF263_19887448_ChIP-Seq_K562_Human1.59484834
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58511220
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56618645
40DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55155167
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.51892712
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.51127639
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48376996
44PPARA_22158963_ChIP-Seq_LIVER_Mouse1.47278805
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46823933
46REST_21632747_ChIP-Seq_MESCs_Mouse1.46029002
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45698589
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45629092
49VDR_22108803_ChIP-Seq_LS180_Human1.44560444
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44429199
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.43534375
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42653647
53CREB1_26743006_Chip-Seq_LNCaP_Human1.41512892
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41232288
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40424677
56SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39153247
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39104667
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38035664
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37881392
60SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.37045768
61WDR5_24793694_ChIP-Seq_LNCAP_Human1.36669868
62RUNX1_26923725_Chip-Seq_HPCs_Mouse1.36327236
63* ELF1_20517297_ChIP-Seq_JURKAT_Human1.35958621
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35466171
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35404540
66FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34555457
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.32398863
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.31635480
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.30269167
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30128866
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.29563156
72CIITA_25753668_ChIP-Seq_RAJI_Human1.29415159
73SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29283983
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29240755
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29202777
76KDM5A_27292631_Chip-Seq_BREAST_Human1.29039962
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.28564653
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28014827
79* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27715401
80SOX2_22085726_ChIP-Seq_NPCs_Mouse1.27598886
81PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26560268
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.25679632
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25201188
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25120892
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24195179
86GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.23467812
87* STAT1_17558387_ChIP-Seq_HELA_Human1.22808473
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22579493
89* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.22162502
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22117370
91SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.21125761
92GATA3_21867929_ChIP-Seq_CD8_Mouse1.19864019
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18947581
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18488321
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15702592
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15278731
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14860684
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13833163
99SOX2_21211035_ChIP-Seq_LN229_Human1.13055356
100P53_21459846_ChIP-Seq_SAOS-2_Human1.11705931
101* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11699282
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10616460
103* MITF_21258399_ChIP-Seq_MELANOMA_Human1.10406593
104FOXA2_19822575_ChIP-Seq_HepG2_Human1.09793086
105DROSHA_22980978_ChIP-Seq_HELA_Human1.08763462
106GATA1_22025678_ChIP-Seq_K562_Human1.07962505
107CTCF_20526341_ChIP-Seq_ESCs_Human1.07067691
108PHF8_20622854_ChIP-Seq_HELA_Human1.06801660
109NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06739226
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06433162
111* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.06007797
112RARB_24833708_ChIP-Seq_LIVER_Mouse1.03614396
113ERG_20517297_ChIP-Seq_VCAP_Human1.02956999
114TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02777441
115CTCF_27219007_Chip-Seq_Bcells_Human1.02626754
116SMC4_20622854_ChIP-Seq_HELA_Human1.02053819
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01993013
118TBX20_22328084_ChIP-Seq_HEART_Mouse1.01783622
119TBX20_22080862_ChIP-Seq_HEART_Mouse1.01783622
120TET1_21490601_ChIP-Seq_MESCs_Mouse1.00994637
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00874822
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00567410
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00182124
124KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00174820
125ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99890250
126CBP_20019798_ChIP-Seq_JUKART_Human0.99781338
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99781338
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99733058
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99577501
130SPI1_26923725_Chip-Seq_HPCs_Mouse0.99291914
131KAP1_27257070_Chip-Seq_ESCs_Mouse0.99114359
132MAF_26560356_Chip-Seq_TH2_Human0.99092491
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98809879
134CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98301214
135NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.98212105
136* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96683773
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.96513004
138TET1_21451524_ChIP-Seq_MESCs_Mouse0.96438626
139KLF4_19829295_ChIP-Seq_ESCs_Human0.95903622
140P68_20966046_ChIP-Seq_HELA_Human0.95693702
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.95260987
142OCT4_19829295_ChIP-Seq_ESCs_Human0.94913088
143NANOG_20526341_ChIP-Seq_ESCs_Human0.94224277
144E2F1_20622854_ChIP-Seq_HELA_Human0.93568557
145KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92740081
146FLI1_21867929_ChIP-Seq_CD8_Mouse0.92436183
147BCOR_27268052_Chip-Seq_Bcells_Human0.92427915
148ESET_19884257_ChIP-Seq_ESCs_Mouse0.92172808
149CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92085994
150TP63_22573176_ChIP-Seq_HFKS_Human0.91750512
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91223702
152POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91223702
153CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90676335
154MYC_27129775_Chip-Seq_CORNEA_Mouse0.90559037
155TBL1_22424771_ChIP-Seq_293T_Human0.89815217
156RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89595962
157GATA3_26560356_Chip-Seq_TH1_Human0.88827585
158KDM2B_26808549_Chip-Seq_REH_Human0.88460859
159SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87897191
160PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87836133
161OCT4_20526341_ChIP-Seq_ESCs_Human0.86938539
162GF1_26923725_Chip-Seq_HPCs_Mouse0.85929541
163RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85527209
164JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85258005
165RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85200018
166NFYB_21822215_ChIP-Seq_K562_Human0.84630122
167GATA3_21867929_ChIP-Seq_TH1_Mouse0.83866278
168* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83496658
169SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83476676
170RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83156144
171RNF2_27304074_Chip-Seq_NSC_Mouse0.81478470
172GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80826648
173MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79279862
174FLI1_27457419_Chip-Seq_LIVER_Mouse0.79125714
175DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78764975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.31144739
2MP0001929_abnormal_gametogenesis5.00046091
3MP0008877_abnormal_DNA_methylation4.79737796
4MP0005058_abnormal_lysosome_morphology3.93459420
5MP0002653_abnormal_ependyma_morphology3.90773657
6MP0002009_preneoplasia3.70713195
7MP0002210_abnormal_sex_determination3.56054385
8MP0003172_abnormal_lysosome_physiology3.45736413
9MP0005451_abnormal_body_composition3.29058286
10MP0001145_abnormal_male_reproductive3.05072080
11MP0002161_abnormal_fertility/fecundity3.03433311
12MP0003123_paternal_imprinting3.01087980
13MP0000653_abnormal_sex_gland2.74488312
14MP0003690_abnormal_glial_cell2.52512554
15MP0003787_abnormal_imprinting2.40559122
16MP0005379_endocrine/exocrine_gland_phen2.35477871
17MP0003646_muscle_fatigue2.14743281
18MP0009278_abnormal_bone_marrow2.03689480
19MP0005410_abnormal_fertilization12.5393714
20MP0002160_abnormal_reproductive_system1.96256203
21MP0005670_abnormal_white_adipose1.90788306
22MP0004270_analgesia1.83811871
23MP0002735_abnormal_chemical_nociception1.75835350
24MP0005365_abnormal_bile_salt1.75828689
25MP0002139_abnormal_hepatobiliary_system1.75545875
26MP0005409_darkened_coat_color1.69002436
27MP0003122_maternal_imprinting1.62833359
28MP0001502_abnormal_circadian_rhythm1.61594483
29MP0009840_abnormal_foam_cell1.56336463
30MP0001986_abnormal_taste_sensitivity1.55822155
31MP0002396_abnormal_hematopoietic_system1.50374336
32MP0002736_abnormal_nociception_after1.49548784
33MP0000462_abnormal_digestive_system1.49241454
34MP0004185_abnormal_adipocyte_glucose1.46985513
35MP0000566_synostosis1.45489344
36MP0004858_abnormal_nervous_system1.44752170
37MP0001968_abnormal_touch/_nociception1.40472495
38MP0003329_amyloid_beta_deposits1.36645578
39MP0010094_abnormal_chromosome_stability1.36261471
40MP0004233_abnormal_muscle_weight1.31302189
41MP0008260_abnormal_autophagy1.30392968
42MP0008961_abnormal_basal_metabolism1.29686152
43MP0008995_early_reproductive_senescence1.27539190
44MP0000003_abnormal_adipose_tissue1.27268573
45MP0003283_abnormal_digestive_organ1.24186195
46MP0009780_abnormal_chondrocyte_physiolo1.22289382
47MP0001666_abnormal_nutrient_absorption1.20814221
48MP0002249_abnormal_larynx_morphology1.16499884
49MP0002254_reproductive_system_inflammat1.16369412
50MP0005389_reproductive_system_phenotype1.16246481
51MP0010329_abnormal_lipoprotein_level1.15550768
52MP0005623_abnormal_meninges_morphology1.14013025
53MP0005220_abnormal_exocrine_pancreas1.10412272
54MP0001346_abnormal_lacrimal_gland1.10057035
55MP0003943_abnormal_hepatobiliary_system1.08546869
56MP0010630_abnormal_cardiac_muscle1.06146686
57MP0002733_abnormal_thermal_nociception1.06072983
58MP0001984_abnormal_olfaction1.05913754
59MP0005647_abnormal_sex_gland1.05615726
60MP0002098_abnormal_vibrissa_morphology1.01937818
61MP0005075_abnormal_melanosome_morpholog1.00985130
62MP0005375_adipose_tissue_phenotype1.00037009
63MP0002269_muscular_atrophy0.99501623
64MP0008058_abnormal_DNA_repair0.97031181
65MP0002064_seizures0.96916927
66MP0003111_abnormal_nucleus_morphology0.96260733
67MP0003634_abnormal_glial_cell0.95825690
68MP0003011_delayed_dark_adaptation0.94838597
69MP0000920_abnormal_myelination0.94467324
70MP0002078_abnormal_glucose_homeostasis0.93567233
71MP0009703_decreased_birth_body0.93181522
72MP0004036_abnormal_muscle_relaxation0.91441785
73MP0004808_abnormal_hematopoietic_stem0.91170152
74MP0001730_embryonic_growth_arrest0.89216961
75MP0002734_abnormal_mechanical_nocicepti0.88549160
76MP0001765_abnormal_ion_homeostasis0.86907467
77MP0006276_abnormal_autonomic_nervous0.85708869
78MP0002089_abnormal_postnatal_growth/wei0.85442181
79MP0002166_altered_tumor_susceptibility0.84824357
80MP0003699_abnormal_female_reproductive0.84707394
81MP0004859_abnormal_synaptic_plasticity0.83221895
82MP0008007_abnormal_cellular_replicative0.82963395
83MP0004782_abnormal_surfactant_physiolog0.82109007
84MP0002118_abnormal_lipid_homeostasis0.81249648
85MP0002822_catalepsy0.80634810
86MP0000609_abnormal_liver_physiology0.80150983
87MP0009046_muscle_twitch0.79928448
88MP0003077_abnormal_cell_cycle0.79682509
89MP0004811_abnormal_neuron_physiology0.79157875
90MP0000534_abnormal_ureter_morphology0.79156760
91MP0005076_abnormal_cell_differentiation0.78084870
92MP0000579_abnormal_nail_morphology0.78064545
93MP0002970_abnormal_white_adipose0.77554008
94MP0008057_abnormal_DNA_replication0.77348056
95MP0002282_abnormal_trachea_morphology0.76982153
96MP0002837_dystrophic_cardiac_calcinosis0.76293968
97MP0000955_abnormal_spinal_cord0.75474414
98MP0009115_abnormal_fat_cell0.75345897
99MP0002084_abnormal_developmental_patter0.74838558
100MP0000358_abnormal_cell_content/0.74633102
101MP0003115_abnormal_respiratory_system0.74287367
102MP0000598_abnormal_liver_morphology0.73853469
103MP0003959_abnormal_lean_body0.73444936
104MP0001348_abnormal_lacrimal_gland0.72944294
105MP0001849_ear_inflammation0.72262280
106MP0005397_hematopoietic_system_phenotyp0.72212315
107MP0001545_abnormal_hematopoietic_system0.72212315
108MP0009384_cardiac_valve_regurgitation0.72045877
109MP0004145_abnormal_muscle_electrophysio0.71969674
110MP0003705_abnormal_hypodermis_morpholog0.71889784
111MP0008569_lethality_at_weaning0.71344000
112MP0004381_abnormal_hair_follicle0.71052429
113MP0006138_congestive_heart_failure0.70489360
114MP0003121_genomic_imprinting0.69995525
115MP0002909_abnormal_adrenal_gland0.69600173
116MP0001731_abnormal_postnatal_growth0.69255594
117MP0006072_abnormal_retinal_apoptosis0.69055555
118MP0005253_abnormal_eye_physiology0.68913824
119MP0003942_abnormal_urinary_system0.67938129
120MP0000751_myopathy0.67172296
121MP0008874_decreased_physiological_sensi0.66378597
122MP0010307_abnormal_tumor_latency0.66073980
123MP0003693_abnormal_embryo_hatching0.66044782
124MP0001270_distended_abdomen0.65655916
125MP0003183_abnormal_peptide_metabolism0.65263063
126MP0003861_abnormal_nervous_system0.65073442
127MP0001970_abnormal_pain_threshold0.63771966
128MP0001119_abnormal_female_reproductive0.63251891
129MP0001697_abnormal_embryo_size0.63250288
130MP0002229_neurodegeneration0.61719104
131MP0002085_abnormal_embryonic_tissue0.55390170
132MP0000537_abnormal_urethra_morphology0.55383449
133MP0005380_embryogenesis_phenotype0.55339929
134MP0001672_abnormal_embryogenesis/_devel0.55339929
135MP0000604_amyloidosis0.53568807
136MP0005423_abnormal_somatic_nervous0.52104096
137MP0002152_abnormal_brain_morphology0.51775353
138MP0005187_abnormal_penis_morphology0.51294837
139MP0002080_prenatal_lethality0.51049261
140MP0003632_abnormal_nervous_system0.50940422
141MP0005646_abnormal_pituitary_gland0.49175265
142MP0005551_abnormal_eye_electrophysiolog0.48888406
143MP0002102_abnormal_ear_morphology0.46962664
144MP0002234_abnormal_pharynx_morphology0.46891477
145MP0002693_abnormal_pancreas_physiology0.46866311
146MP0001661_extended_life_span0.46305009
147MP0005666_abnormal_adipose_tissue0.46282407
148MP0000313_abnormal_cell_death0.45510947
149MP0005377_hearing/vestibular/ear_phenot0.44894068
150MP0003878_abnormal_ear_physiology0.44894068
151MP0009672_abnormal_birth_weight0.44257858
152MP0002882_abnormal_neuron_morphology0.43781511
153MP0000749_muscle_degeneration0.43164085
154MP0003786_premature_aging0.42837032
155MP0003984_embryonic_growth_retardation0.42573464
156MP0000350_abnormal_cell_proliferation0.41808251
157MP0002088_abnormal_embryonic_growth/wei0.41464461
158MP0004957_abnormal_blastocyst_morpholog0.40398412
159MP0002184_abnormal_innervation0.40210366
160MP0004264_abnormal_extraembryonic_tissu0.39541364
161MP0000569_abnormal_digit_pigmentation0.38717397
162MP0005391_vision/eye_phenotype0.38520828
163MP0001944_abnormal_pancreas_morphology0.38151953
164MP0004084_abnormal_cardiac_muscle0.38109111

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.49533718
2Abnormal respiratory motile cilium morphology (HP:0005938)7.19848404
3Abnormal respiratory epithelium morphology (HP:0012253)7.19848404
4Infertility (HP:0000789)6.65999274
5Rhinitis (HP:0012384)6.50719508
6Chronic bronchitis (HP:0004469)6.30336356
7Nasal polyposis (HP:0100582)5.61484767
8Abnormal ciliary motility (HP:0012262)5.46984431
9Male infertility (HP:0003251)4.98043161
10Abnormality of the nasal mucosa (HP:0000433)4.67850286
11Nephronophthisis (HP:0000090)4.13303401
12Bronchiectasis (HP:0002110)4.03451911
13Bronchitis (HP:0012387)4.03292869
14Abnormality of the lower motor neuron (HP:0002366)3.89762163
15Hyperacusis (HP:0010780)3.51367892
16Abnormal spermatogenesis (HP:0008669)3.36252986
17Increased cerebral lipofuscin (HP:0011813)3.31252780
18Gonadotropin excess (HP:0000837)3.20181664
19Urinary glycosaminoglycan excretion (HP:0003541)3.19853315
20Mucopolysacchariduria (HP:0008155)3.19853315
21J-shaped sella turcica (HP:0002680)3.19682684
22Increased neuronal autofluorescent lipopigment (HP:0002074)3.15381746
23Tubulointerstitial nephritis (HP:0001970)3.14220404
24Macroorchidism (HP:0000053)3.12294106
25Deep venous thrombosis (HP:0002625)3.11973469
26Abnormality of the renal medulla (HP:0100957)3.03818361
27Abnormality of polysaccharide metabolism (HP:0011012)2.99784895
28Abnormality of glycosaminoglycan metabolism (HP:0004371)2.99784895
29Abnormality of mucopolysaccharide metabolism (HP:0011020)2.99784895
30Abnormality of glycolipid metabolism (HP:0010969)2.95846051
31Abnormality of liposaccharide metabolism (HP:0010968)2.95846051
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.95846051
33Recurrent otitis media (HP:0000403)2.95451975
34Impulsivity (HP:0100710)2.93854217
35Dysostosis multiplex (HP:0000943)2.89245031
36Heterotopia (HP:0002282)2.78808439
37Abnormality of the periventricular white matter (HP:0002518)2.73077997
38Urethral obstruction (HP:0000796)2.72159434
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.65085485
40Dysmetric saccades (HP:0000641)2.56106512
41Amyotrophic lateral sclerosis (HP:0007354)2.53361391
42Recurrent bronchitis (HP:0002837)2.51930544
43Colitis (HP:0002583)2.51295247
44Germ cell neoplasia (HP:0100728)2.48618198
45Renovascular hypertension (HP:0100817)2.45117375
46Abnormal gallbladder physiology (HP:0012438)2.44328951
47Cholecystitis (HP:0001082)2.44328951
48Overriding aorta (HP:0002623)2.42887504
49Neuronal loss in central nervous system (HP:0002529)2.41326020
50Hemangiomatosis (HP:0007461)2.39119900
51Tubulointerstitial abnormality (HP:0001969)2.38865633
52Visceral angiomatosis (HP:0100761)2.37237559
53Tubular atrophy (HP:0000092)2.36829254
54Molar tooth sign on MRI (HP:0002419)2.35091308
55Abnormality of midbrain morphology (HP:0002418)2.35091308
56Testicular neoplasm (HP:0010788)2.32723173
57Loss of speech (HP:0002371)2.32317266
58EMG: neuropathic changes (HP:0003445)2.31953129
59Obstructive sleep apnea (HP:0002870)2.29515565
60Azoospermia (HP:0000027)2.29406564
61Complement deficiency (HP:0004431)2.27629353
62Recurrent sinusitis (HP:0011108)2.25252979
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23732564
64Abnormality of the fingertips (HP:0001211)2.23569533
65Hypoplasia of the thymus (HP:0000778)2.23261383
66Impaired proprioception (HP:0010831)2.22445441
67Reticulocytosis (HP:0001923)2.18102026
68Panhypogammaglobulinemia (HP:0003139)2.16361902
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15335565
70Abnormality of the thoracic spine (HP:0100711)2.15091963
71Elfin facies (HP:0004428)2.14871984
72Postaxial foot polydactyly (HP:0001830)2.14752334
73Hypoglycemic seizures (HP:0002173)2.11866070
74Agammaglobulinemia (HP:0004432)2.09249115
75Peripheral hypomyelination (HP:0007182)2.08857335
76Ulnar claw (HP:0001178)2.06983631
77Insomnia (HP:0100785)2.06576621
78Hyporeflexia of lower limbs (HP:0002600)2.05080287
79Glomerulonephritis (HP:0000099)2.04676614
80Postural instability (HP:0002172)2.04593785
81Abnormality of the sella turcica (HP:0002679)2.04220307
82Cardiomegaly (HP:0001640)2.03894800
83Spastic tetraparesis (HP:0001285)2.01983474
84Broad face (HP:0000283)2.01722657
85Hyperglycinuria (HP:0003108)2.01067639
86Lower limb hyperreflexia (HP:0002395)2.00866436
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.2540887
88Dynein arm defect of respiratory motile cilia (HP:0012255)10.7594499
89Absent/shortened dynein arms (HP:0200106)10.7594499
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99933662
91Medial flaring of the eyebrow (HP:0010747)1.99622190
92Hyperinsulinemic hypoglycemia (HP:0000825)1.99305888
93Thoracic kyphosis (HP:0002942)1.98980909
94Lymphangioma (HP:0100764)1.98653031
95Systemic lupus erythematosus (HP:0002725)1.98492667
96Limb hypertonia (HP:0002509)1.97055806
97Ankle clonus (HP:0011448)1.95107804
98Obsessive-compulsive behavior (HP:0000722)1.94527209
99Metaphyseal cupping (HP:0003021)1.93326622
100Slow saccadic eye movements (HP:0000514)1.91691205
101Hypokinesia (HP:0002375)1.90536746
102Lower limb asymmetry (HP:0100559)1.89990924
103Abnormal large intestine physiology (HP:0012700)1.88983715
104Bowel incontinence (HP:0002607)1.88505358
105Decreased motor nerve conduction velocity (HP:0003431)1.84248953
106Gonadal dysgenesis (HP:0000133)1.82594377
107Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82524593
108Short ribs (HP:0000773)1.81764167
109Sex reversal (HP:0012245)1.80318459
110Abnormal sex determination (HP:0012244)1.80318459
111Menstrual irregularities (HP:0000858)1.79721581
112Increased nuchal translucency (HP:0010880)1.79685251
113Cutis marmorata (HP:0000965)1.79670606
114Ketoacidosis (HP:0001993)1.79478862
115Abnormality of the diencephalon (HP:0010662)1.78709395
116Truncal obesity (HP:0001956)1.78592016
117Choroideremia (HP:0001139)1.78077422
118Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77972091
119Microglossia (HP:0000171)1.77342072
120Polydipsia (HP:0001959)1.77331947
121Abnormal drinking behavior (HP:0030082)1.77331947
122Depression (HP:0000716)1.77305046
123Hypercholesterolemia (HP:0003124)1.77101705
124Degeneration of anterior horn cells (HP:0002398)1.77080854
125Abnormality of the anterior horn cell (HP:0006802)1.77080854
126Cystic liver disease (HP:0006706)1.76425623
127Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74568927
128Vacuolated lymphocytes (HP:0001922)1.74327096
129Cellulitis (HP:0100658)1.72680042
130Neoplasm of the heart (HP:0100544)1.71869755
131Stage 5 chronic kidney disease (HP:0003774)1.70536721
132Hypoplasia of the brainstem (HP:0002365)1.70509135
133Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70509135
134Large hands (HP:0001176)1.69680201
135Renal dysplasia (HP:0000110)1.69630533
136Esophageal varix (HP:0002040)1.68375029
137Termporal pattern (HP:0011008)1.67886977
138Insidious onset (HP:0003587)1.67886977
139Diminished motivation (HP:0000745)1.67832365
140Back pain (HP:0003418)1.67633488
141Oculomotor apraxia (HP:0000657)1.67170769
142Tubulointerstitial fibrosis (HP:0005576)1.66840367
143Centrally nucleated skeletal muscle fibers (HP:0003687)1.66710764
144Difficulty climbing stairs (HP:0003551)1.66337720
145Abnormality of ocular smooth pursuit (HP:0000617)1.65898050
146Congenital hepatic fibrosis (HP:0002612)1.65397878
147Pointed chin (HP:0000307)1.65325342
148Abnormality of saccadic eye movements (HP:0000570)1.63669801
149Asymmetric septal hypertrophy (HP:0001670)1.63593224
150Rectal prolapse (HP:0002035)1.63070709
151Postaxial hand polydactyly (HP:0001162)1.62780114
152Truncus arteriosus (HP:0001660)1.62525830
153Supranuclear gaze palsy (HP:0000605)1.61501851
154Personality changes (HP:0000751)1.60395192
155Growth hormone excess (HP:0000845)1.60265612
156Hemiparesis (HP:0001269)1.60061604
157Precocious puberty (HP:0000826)1.59742944
158Neonatal hypoglycemia (HP:0001998)1.59680773
159Dyschromatopsia (HP:0007641)1.59580873
160Broad distal phalanx of finger (HP:0009836)1.58734463
161Polycystic kidney dysplasia (HP:0000113)1.57978708
162Cerebellar dysplasia (HP:0007033)1.57283476
163Papillary thyroid carcinoma (HP:0002895)1.57266018
164Turricephaly (HP:0000262)1.57062419
165Abnormality of reticulocytes (HP:0004312)1.56700463
166Bundle branch block (HP:0011710)1.55392026
167Neurofibrillary tangles (HP:0002185)1.53749320
168Short thorax (HP:0010306)1.52228920
169Fibular hypoplasia (HP:0003038)1.50904872
170Pendular nystagmus (HP:0012043)1.50332095
171Pachygyria (HP:0001302)1.50160658
172Supernumerary spleens (HP:0009799)1.49409004
173Hand muscle atrophy (HP:0009130)1.48856332
174Absent epiphyses (HP:0010577)1.48593228
175Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.48593228
176Deformed sella turcica (HP:0002681)1.46012061
177Retinal atrophy (HP:0001105)1.44206510
178Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.42800459
179Aplasia/Hypoplasia of the tongue (HP:0010295)1.41979891
180Global brain atrophy (HP:0002283)1.41716201
181Polymicrogyria (HP:0002126)1.40149147
182Abnormality of dentin (HP:0010299)1.39193613
183Pancreatic fibrosis (HP:0100732)1.39170844
184Upper motor neuron abnormality (HP:0002127)1.39037805
185Cerebral inclusion bodies (HP:0100314)1.38819020
186Segmental peripheral demyelination/remyelination (HP:0003481)1.38761540
187Bony spicule pigmentary retinopathy (HP:0007737)1.38290583
188Glucose intolerance (HP:0000833)1.37554013
189Lissencephaly (HP:0001339)1.37168223
190Abnormal biliary tract physiology (HP:0012439)1.37029816
191Bile duct proliferation (HP:0001408)1.37029816
192Type II diabetes mellitus (HP:0005978)1.36648359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.13368680
2PDK47.13368680
3PRKD35.69544444
4TESK15.12130591
5PDK24.32099001
6ICK4.11629358
7SMG13.09707771
8PNCK2.36950255
9TSSK62.24447424
10SIK12.19949222
11EEF2K1.98489483
12NEK21.87863951
13PTK2B1.86443276
14WNK41.84861012
15PKN21.73554272
16CAMK1D1.66447619
17PASK1.63807102
18STK381.60550100
19MAP3K131.59069822
20CDK121.57895337
21CDK31.54831711
22NEK61.50605524
23TNK21.50333730
24LMTK21.49870305
25STK391.48255753
26PRPF4B1.45147940
27TYRO31.30830644
28MAP2K31.27174220
29MAP2K21.26786916
30MAP3K91.26640175
31MAP3K71.18912226
32FGFR31.16155570
33MAPKAPK31.15599143
34DYRK1B1.13455885
35MAPK111.01825412
36SGK31.01436387
37RPS6KL11.01095396
38RPS6KC11.01095396
39DAPK20.99554758
40CDK40.96061558
41WNK10.95939784
42KSR20.93521703
43CDC70.93315717
44NLK0.88625590
45PRKD20.85455933
46PDK10.84393295
47SGK20.83988852
48RPS6KA60.82959604
49TTK0.81256023
50STK30.80766605
51MAPK120.80606956
52TESK20.80074738
53CAMK1G0.78394536
54TRIB30.75012571
55MAP3K30.73707227
56SIK20.71858880
57TAOK10.71447412
58CDK70.68953331
59ALK0.68571981
60MAPK150.68508067
61TAF10.68350809
62SGK2230.68213207
63SGK4940.68213207
64MAP3K40.67326993
65MTOR0.66853485
66LATS20.65821315
67RIPK10.65279078
68CDC42BPA0.65202993
69CCNB10.65069237
70NTRK10.64637295
71CHEK10.63553313
72RET0.62677468
73IRAK10.62349941
74PAK60.60592785
75UHMK10.55147560
76MINK10.54871657
77DAPK10.53619610
78PINK10.52776247
79NTRK20.52688779
80DYRK30.52585032
81WEE10.52269881
82PRKAA20.52105914
83CDK90.51679774
84MARK20.51437012
85MUSK0.50537067
86ITK0.48038446
87MAP3K20.47877345
88CDK60.47732997
89PTK60.47364704
90MAPKAPK50.47264558
91CHEK20.45676389
92MAP2K60.45572938
93AKT20.43243147
94ATR0.42908982
95MAPK140.41033999
96PRKAA10.41014572
97FES0.40917092
98PRKD10.40809148
99CSF1R0.40092596
100BTK0.38306417
101CAMK40.38206530
102MAP3K10.38154902
103PDPK10.38125155
104ATM0.37544798
105AKT10.36775605
106MAP3K110.36248942
107MAPK10.36156548
108MAPK30.36035546
109PLK40.35923487
110RIPK40.34114288
111NTRK30.33583196
112IRAK20.33267188
113RPS6KB20.31837244
114PAK10.30613393
115LATS10.30315422
116RPS6KB10.28573912
117MARK30.27466361
118STK38L0.27460600
119RPS6KA20.26521775
120PLK10.24814816
121FGFR40.24434675
122BUB10.23536950
123CAMKK10.23424393
124EPHB10.22765816
125PHKG20.22511706
126PHKG10.22511706
127BRAF0.21689222
128MATK0.20879249
129MAP2K40.20551201
130SIK30.20502935
131MAP3K100.19946726
132CDK20.18944191
133PAK20.17495525
134PAK40.17096087
135GSK3B0.17035423
136SCYL20.16938681
137AURKA0.16509966
138CDK10.15783262
139BRSK20.15300071
140HIPK20.15066586
141RPS6KA10.14377794
142ERN10.14283323
143MAPK100.14092119
144STK110.13402177
145FGFR20.13328373
146MAPK80.12917100
147CSNK1E0.11565838
148CSNK1D0.11331615
149PRKCZ0.11285776
150PRKCG0.10934438
151PDGFRA0.10000942
152LIMK10.09448140

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.56074932
2Pyruvate metabolism_Homo sapiens_hsa006203.39826397
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.29620236
4Other glycan degradation_Homo sapiens_hsa005113.20399339
5Selenocompound metabolism_Homo sapiens_hsa004502.90199431
6Fatty acid biosynthesis_Homo sapiens_hsa000612.84307182
7Glucagon signaling pathway_Homo sapiens_hsa049222.60163988
8Oocyte meiosis_Homo sapiens_hsa041142.46692290
9Propanoate metabolism_Homo sapiens_hsa006402.45617358
10Vitamin B6 metabolism_Homo sapiens_hsa007502.28047760
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.25441778
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.22611621
13Basal transcription factors_Homo sapiens_hsa030222.19878611
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.12272111
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.09296292
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02196905
17Notch signaling pathway_Homo sapiens_hsa043302.00553072
18Linoleic acid metabolism_Homo sapiens_hsa005911.88746718
19Glycerolipid metabolism_Homo sapiens_hsa005611.87076357
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82756466
21mRNA surveillance pathway_Homo sapiens_hsa030151.79488954
22RNA transport_Homo sapiens_hsa030131.67694698
23Acute myeloid leukemia_Homo sapiens_hsa052211.65583479
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.63129021
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.59194809
26Lysosome_Homo sapiens_hsa041421.58925241
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.56917651
28Prion diseases_Homo sapiens_hsa050201.56797798
29Arginine biosynthesis_Homo sapiens_hsa002201.47156775
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46046603
31B cell receptor signaling pathway_Homo sapiens_hsa046621.44332807
32Fructose and mannose metabolism_Homo sapiens_hsa000511.39783099
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38166214
34Non-small cell lung cancer_Homo sapiens_hsa052231.37724013
35Insulin secretion_Homo sapiens_hsa049111.35287971
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.35207779
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33618130
38Pentose phosphate pathway_Homo sapiens_hsa000301.33558275
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28731352
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26587385
41Synaptic vesicle cycle_Homo sapiens_hsa047211.23923715
42Fatty acid metabolism_Homo sapiens_hsa012121.23463903
43Fanconi anemia pathway_Homo sapiens_hsa034601.22818067
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21811804
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.21262934
46Hedgehog signaling pathway_Homo sapiens_hsa043401.16946680
47Carbon metabolism_Homo sapiens_hsa012001.14263011
48Chronic myeloid leukemia_Homo sapiens_hsa052201.12853827
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.08673245
50VEGF signaling pathway_Homo sapiens_hsa043701.08418836
51Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08316916
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05773947
53Choline metabolism in cancer_Homo sapiens_hsa052311.04784367
54Estrogen signaling pathway_Homo sapiens_hsa049151.03705960
55Fatty acid degradation_Homo sapiens_hsa000711.03418082
56PPAR signaling pathway_Homo sapiens_hsa033201.01869346
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01254639
58Biosynthesis of amino acids_Homo sapiens_hsa012301.00815447
59Amphetamine addiction_Homo sapiens_hsa050310.99684870
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99629293
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98444766
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87939642
63ABC transporters_Homo sapiens_hsa020100.87779612
64Endocytosis_Homo sapiens_hsa041440.87712465
65AMPK signaling pathway_Homo sapiens_hsa041520.86693626
66ErbB signaling pathway_Homo sapiens_hsa040120.86402429
67Long-term potentiation_Homo sapiens_hsa047200.85905187
68Butanoate metabolism_Homo sapiens_hsa006500.84996121
69mTOR signaling pathway_Homo sapiens_hsa041500.84608395
70Antigen processing and presentation_Homo sapiens_hsa046120.84083097
71Arginine and proline metabolism_Homo sapiens_hsa003300.83108653
72Inositol phosphate metabolism_Homo sapiens_hsa005620.82637133
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82018458
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81685674
75Colorectal cancer_Homo sapiens_hsa052100.81409140
76Cell cycle_Homo sapiens_hsa041100.81138452
77Cardiac muscle contraction_Homo sapiens_hsa042600.79656689
78Complement and coagulation cascades_Homo sapiens_hsa046100.77103428
79Glioma_Homo sapiens_hsa052140.76507033
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74073648
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.73967519
82Insulin signaling pathway_Homo sapiens_hsa049100.72830174
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71522035
84RNA degradation_Homo sapiens_hsa030180.70541870
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70113601
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.69865597
87Sulfur relay system_Homo sapiens_hsa041220.67672282
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67125315
89Insulin resistance_Homo sapiens_hsa049310.66885189
90Ether lipid metabolism_Homo sapiens_hsa005650.66052247
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.65328166
92Basal cell carcinoma_Homo sapiens_hsa052170.64720536
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64638987
94Prostate cancer_Homo sapiens_hsa052150.64489227
95Taste transduction_Homo sapiens_hsa047420.64252975
96Pancreatic cancer_Homo sapiens_hsa052120.63428573
97Type II diabetes mellitus_Homo sapiens_hsa049300.60727966
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60514320
99GnRH signaling pathway_Homo sapiens_hsa049120.60113726
100Huntingtons disease_Homo sapiens_hsa050160.59441254
101Bile secretion_Homo sapiens_hsa049760.58694270
102Renin secretion_Homo sapiens_hsa049240.57836186
103Purine metabolism_Homo sapiens_hsa002300.56737313
104Fat digestion and absorption_Homo sapiens_hsa049750.55948918
105One carbon pool by folate_Homo sapiens_hsa006700.52639110
106Vibrio cholerae infection_Homo sapiens_hsa051100.52167380
107Sphingolipid metabolism_Homo sapiens_hsa006000.50946773
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49927840
109Prolactin signaling pathway_Homo sapiens_hsa049170.48366474
110Phenylalanine metabolism_Homo sapiens_hsa003600.47703894
111N-Glycan biosynthesis_Homo sapiens_hsa005100.47153395
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46801827
113Renal cell carcinoma_Homo sapiens_hsa052110.46433756
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43680293
115beta-Alanine metabolism_Homo sapiens_hsa004100.41631703
116FoxO signaling pathway_Homo sapiens_hsa040680.40161006
117Fatty acid elongation_Homo sapiens_hsa000620.38092484
118Thyroid hormone synthesis_Homo sapiens_hsa049180.37887970
119Folate biosynthesis_Homo sapiens_hsa007900.37626799
120Pancreatic secretion_Homo sapiens_hsa049720.37564104
121Regulation of autophagy_Homo sapiens_hsa041400.37116334
122Wnt signaling pathway_Homo sapiens_hsa043100.36656049
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36037208
124Circadian rhythm_Homo sapiens_hsa047100.35871801
125Lysine degradation_Homo sapiens_hsa003100.35024321
126Base excision repair_Homo sapiens_hsa034100.34705402
127Mineral absorption_Homo sapiens_hsa049780.33063609
128Gastric acid secretion_Homo sapiens_hsa049710.32561046
129Dopaminergic synapse_Homo sapiens_hsa047280.32521242
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31356191
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30610203
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30470943
133Hippo signaling pathway_Homo sapiens_hsa043900.29856760
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.29612723
135Thyroid cancer_Homo sapiens_hsa052160.29025726
136Endometrial cancer_Homo sapiens_hsa052130.26904144
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.26352947
138Tight junction_Homo sapiens_hsa045300.24255116
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.22516846
140Epstein-Barr virus infection_Homo sapiens_hsa051690.22285882
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.22089429
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21983811
143Circadian entrainment_Homo sapiens_hsa047130.21464681

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