ANGEL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)5.45110579
2neural tube formation (GO:0001841)4.90294555
3regulation of meiosis I (GO:0060631)4.87638610
4DNA damage induced protein phosphorylation (GO:0006975)4.73241390
5regulation of meiosis (GO:0040020)4.34615378
6positive regulation of DNA-dependent DNA replication (GO:2000105)4.20173204
7regulation of histone H3-K27 methylation (GO:0061085)4.11138414
8fat-soluble vitamin biosynthetic process (GO:0042362)4.06646042
9mitotic metaphase plate congression (GO:0007080)3.90607137
10meiotic chromosome segregation (GO:0045132)3.81735978
11negative regulation of DNA-dependent DNA replication (GO:2000104)3.78469770
12regulation of female gonad development (GO:2000194)3.75808066
13protein prenylation (GO:0018342)3.75405401
14prenylation (GO:0097354)3.75405401
15maturation of 5.8S rRNA (GO:0000460)3.74508084
16poly(A)+ mRNA export from nucleus (GO:0016973)3.72401813
17piRNA metabolic process (GO:0034587)3.68235825
18female gamete generation (GO:0007292)3.65599395
19behavioral response to nicotine (GO:0035095)3.61030762
20regulation of translation, ncRNA-mediated (GO:0045974)3.60852260
21negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.60852260
22negative regulation of translation, ncRNA-mediated (GO:0040033)3.60852260
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.59654374
24DNA double-strand break processing (GO:0000729)3.58875399
25positive regulation of granulocyte differentiation (GO:0030854)3.58412294
26N-terminal protein amino acid acetylation (GO:0006474)3.56962457
27metaphase plate congression (GO:0051310)3.55184875
28mitotic sister chromatid cohesion (GO:0007064)3.50729054
29monoubiquitinated protein deubiquitination (GO:0035520)3.49708588
30regulation of meiotic cell cycle (GO:0051445)3.48973227
31positive regulation of megakaryocyte differentiation (GO:0045654)3.46237666
32meiotic cell cycle (GO:0051321)3.42328668
33attachment of spindle microtubules to kinetochore (GO:0008608)3.42209653
34sister chromatid cohesion (GO:0007062)3.40848379
35indolalkylamine metabolic process (GO:0006586)3.38779503
36mitotic chromosome condensation (GO:0007076)3.37628118
37nonmotile primary cilium assembly (GO:0035058)3.36761454
38DNA damage response, signal transduction resulting in transcription (GO:0042772)3.34579620
39CENP-A containing nucleosome assembly (GO:0034080)3.31991959
40RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.30551499
41establishment of chromosome localization (GO:0051303)3.28662660
42negative regulation of meiosis (GO:0045835)3.27896522
43replication fork processing (GO:0031297)3.27141589
44DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.26608040
45indole-containing compound catabolic process (GO:0042436)3.23189108
46indolalkylamine catabolic process (GO:0046218)3.23189108
47tryptophan catabolic process (GO:0006569)3.23189108
48chromatin remodeling at centromere (GO:0031055)3.21553639
49positive regulation of meiosis (GO:0045836)3.19066297
50kinetochore assembly (GO:0051382)3.17821438
51negative regulation of hormone metabolic process (GO:0032351)3.16502147
52negative regulation of hormone biosynthetic process (GO:0032353)3.16502147
53DNA replication-independent nucleosome organization (GO:0034724)3.15795410
54DNA replication-independent nucleosome assembly (GO:0006336)3.15795410
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15695757
56positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.15052582
57microtubule depolymerization (GO:0007019)3.13408947
58establishment of protein localization to Golgi (GO:0072600)3.12773082
59double-strand break repair via homologous recombination (GO:0000724)3.12763459
60L-fucose catabolic process (GO:0042355)3.12657782
61fucose catabolic process (GO:0019317)3.12657782
62L-fucose metabolic process (GO:0042354)3.12657782
63recombinational repair (GO:0000725)3.12055161
64histone mRNA catabolic process (GO:0071044)3.11589765
65protein K63-linked deubiquitination (GO:0070536)3.10653521
66kinetochore organization (GO:0051383)3.10269094
67microtubule nucleation (GO:0007020)3.07537118
68regulation of exit from mitosis (GO:0007096)3.07324580
69type B pancreatic cell development (GO:0003323)3.04963223
70DNA methylation involved in gamete generation (GO:0043046)3.01337508
71glycerophospholipid catabolic process (GO:0046475)3.00138931
72photoreceptor cell maintenance (GO:0045494)2.99774343
73positive T cell selection (GO:0043368)2.99525157
74positive regulation of meiotic cell cycle (GO:0051446)2.99340514
75DNA alkylation (GO:0006305)2.98721789
76DNA methylation (GO:0006306)2.98721789
77mismatch repair (GO:0006298)2.98638830
78tryptophan metabolic process (GO:0006568)2.98503622
79retinal cone cell development (GO:0046549)2.98491674
80protein K48-linked deubiquitination (GO:0071108)2.96662369
81regulation of DNA endoreduplication (GO:0032875)2.94397129
82serotonin receptor signaling pathway (GO:0007210)2.92145527
83cilium morphogenesis (GO:0060271)2.91425746
84signal peptide processing (GO:0006465)2.91071201
85regulation of transcription from RNA polymerase I promoter (GO:0006356)2.90652066
86negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.90582040
87negative regulation of reproductive process (GO:2000242)2.89426647
88protein localization to chromosome, centromeric region (GO:0071459)2.88234903
89rRNA catabolic process (GO:0016075)2.88204009
90response to pheromone (GO:0019236)2.87652625
91oocyte maturation (GO:0001556)2.87502164
92negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.87228202
93negative regulation of DNA-templated transcription, elongation (GO:0032785)2.87228202
94cytoplasmic mRNA processing body assembly (GO:0033962)2.86034307
95reciprocal DNA recombination (GO:0035825)2.85940845
96reciprocal meiotic recombination (GO:0007131)2.85940845
97regulation of RIG-I signaling pathway (GO:0039535)2.85699316
98protein K6-linked ubiquitination (GO:0085020)2.85216823
99DNA replication checkpoint (GO:0000076)2.84059325
100negative regulation of DNA recombination (GO:0045910)2.83691561
101intra-S DNA damage checkpoint (GO:0031573)2.81875928
102myoblast migration (GO:0051451)2.81555630
103microtubule anchoring (GO:0034453)2.81297107
104detection of light stimulus involved in visual perception (GO:0050908)2.81145664
105detection of light stimulus involved in sensory perception (GO:0050962)2.81145664
106histone H2A monoubiquitination (GO:0035518)2.80977718
107phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.80555432
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.80199574
109regulation of mitotic spindle checkpoint (GO:1903504)2.80199574
110negative regulation of circadian rhythm (GO:0042754)2.79555698
111regulation of centriole replication (GO:0046599)2.78975634
112male meiosis (GO:0007140)2.78580594
113positive regulation of developmental pigmentation (GO:0048087)2.78129302
114negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77292083
115epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73474178
116regulation of cell maturation (GO:1903429)2.72755981
117regulation of hippo signaling (GO:0035330)2.70049353
118spindle checkpoint (GO:0031577)2.70009410
119thyroid hormone metabolic process (GO:0042403)2.69884368
120histone exchange (GO:0043486)2.69195047
121pyrimidine nucleobase catabolic process (GO:0006208)2.68888985
122activated T cell proliferation (GO:0050798)2.68169493
123kynurenine metabolic process (GO:0070189)2.67761969
124regulation of glucocorticoid metabolic process (GO:0031943)2.67654395
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.67156047
126DNA replication initiation (GO:0006270)2.66337476
127peptidyl-lysine trimethylation (GO:0018023)2.66331600
128chaperone-mediated protein transport (GO:0072321)2.66261948
129reflex (GO:0060004)2.65489683
130protein K11-linked ubiquitination (GO:0070979)2.65193152
131atrial cardiac muscle cell action potential (GO:0086014)2.64143692
132protein localization to chromosome (GO:0034502)2.64011680
133positive thymic T cell selection (GO:0045059)2.63911067
134interkinetic nuclear migration (GO:0022027)2.63905941
135negative regulation of histone methylation (GO:0031061)2.63613518
136lymphoid progenitor cell differentiation (GO:0002320)2.63474157
137histone H2A ubiquitination (GO:0033522)2.63247002
138sulfation (GO:0051923)2.62306664
139kidney morphogenesis (GO:0060993)2.62012712
140regulation of nuclear cell cycle DNA replication (GO:0033262)2.60490387
141histone H3-K9 methylation (GO:0051567)2.59457634
142presynaptic membrane assembly (GO:0097105)2.58279899
143regulation of retinoic acid receptor signaling pathway (GO:0048385)2.58124197
144positive regulation of gluconeogenesis (GO:0045722)2.57214625
145centriole replication (GO:0007099)2.56837251
146behavioral response to ethanol (GO:0048149)2.56471349
147pyrimidine dimer repair (GO:0006290)2.55163655
148regulation of posttranscriptional gene silencing (GO:0060147)2.54889937
149regulation of gene silencing by miRNA (GO:0060964)2.54889937
150regulation of gene silencing by RNA (GO:0060966)2.54889937
151regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.54802124
152regulation of centrosome duplication (GO:0010824)2.54484708
153cilium or flagellum-dependent cell motility (GO:0001539)2.54072027
154regulation of glucokinase activity (GO:0033131)2.53760852
155regulation of hexokinase activity (GO:1903299)2.53760852
156mitotic sister chromatid segregation (GO:0000070)2.53518658
157centriole assembly (GO:0098534)2.53166675
158positive regulation of oligodendrocyte differentiation (GO:0048714)2.53158435
159negative regulation of cell aging (GO:0090344)2.52625371
160cilium organization (GO:0044782)2.52594686
161maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51795542
162pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.51328946
163histone H3-K4 trimethylation (GO:0080182)2.50901435
164histone deubiquitination (GO:0016578)2.50845149
165rRNA methylation (GO:0031167)2.50601686
166nucleotide-excision repair, DNA gap filling (GO:0006297)2.50113569
167L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.50079909
168histone H2A acetylation (GO:0043968)2.48910094
169lipid translocation (GO:0034204)2.47735430
170phospholipid translocation (GO:0045332)2.47735430
171regulation of DNA methylation (GO:0044030)2.47268594
172chromosome segregation (GO:0007059)2.46792064
173cilium assembly (GO:0042384)2.46785753
174DNA deamination (GO:0045006)2.46666436
175protein K48-linked ubiquitination (GO:0070936)2.46652507
176regulation of sarcomere organization (GO:0060297)2.46545608
177negative regulation of meiotic cell cycle (GO:0051447)2.45834746
178embryonic epithelial tube formation (GO:0001838)2.45684959
179mitotic spindle checkpoint (GO:0071174)2.45532471
180neuron fate determination (GO:0048664)2.45330911
181negative regulation of mitotic sister chromatid segregation (GO:0033048)2.45276790
182indole-containing compound metabolic process (GO:0042430)2.44234167
183DNA demethylation (GO:0080111)2.43754159
184somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.43381960
185isotype switching (GO:0045190)2.43381960
186somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.43381960
187regulation of establishment of cell polarity (GO:2000114)2.42640702
188cAMP catabolic process (GO:0006198)2.42423715
189spinal cord motor neuron differentiation (GO:0021522)2.40652844
190synapsis (GO:0007129)2.40509759
191photoreceptor cell development (GO:0042461)2.39565510
192exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.38884741
193protein targeting to Golgi (GO:0000042)2.38484962
194gene silencing by RNA (GO:0031047)2.38204320
195microtubule organizing center organization (GO:0031023)2.35322450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.69793439
2E2F7_22180533_ChIP-Seq_HELA_Human4.35307290
3EZH2_22144423_ChIP-Seq_EOC_Human3.24822772
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.01787527
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.77786589
6ZNF274_21170338_ChIP-Seq_K562_Hela2.68336139
7GBX2_23144817_ChIP-Seq_PC3_Human2.54635665
8VDR_22108803_ChIP-Seq_LS180_Human2.54112595
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.53755849
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51539317
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.41859493
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30802627
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24943383
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.24099085
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21682560
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20332290
17FUS_26573619_Chip-Seq_HEK293_Human2.04511739
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03982753
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99386068
20TAF15_26573619_Chip-Seq_HEK293_Human1.98824913
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91789193
22EWS_26573619_Chip-Seq_HEK293_Human1.89837606
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82827809
24KAP1_22055183_ChIP-Seq_ESCs_Mouse1.80603662
25RNF2_27304074_Chip-Seq_NSC_Mouse1.77483996
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.76478427
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76478427
28LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68705854
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.66458739
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64350796
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63035558
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61731832
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60619225
34ELK1_19687146_ChIP-ChIP_HELA_Human1.60275854
35IGF1R_20145208_ChIP-Seq_DFB_Human1.58628982
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.58394765
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57471541
38CBP_20019798_ChIP-Seq_JUKART_Human1.57471541
39* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54700761
40CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49859026
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49800274
42* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.48162584
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48090821
44* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47674393
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.46982964
46BCAT_22108803_ChIP-Seq_LS180_Human1.46325006
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46260154
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.45212980
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43097198
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42939484
51* NANOG_18555785_Chip-Seq_ESCs_Mouse1.42723949
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.41849949
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40464641
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40228758
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.38676482
56MYC_18940864_ChIP-ChIP_HL60_Human1.37327551
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36623397
58* CRX_20693478_ChIP-Seq_RETINA_Mouse1.33561454
59AR_21572438_ChIP-Seq_LNCaP_Human1.31720352
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28977895
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28957515
62TCF4_22108803_ChIP-Seq_LS180_Human1.27774265
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27061483
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.26196598
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26140233
66* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.24782065
67* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24405197
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23067290
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.22889864
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22789022
71MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22674611
72* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21507400
73* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20430475
74RUNX2_22187159_ChIP-Seq_PCA_Human1.19971678
75* VDR_23849224_ChIP-Seq_CD4+_Human1.19617191
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17991786
77P300_19829295_ChIP-Seq_ESCs_Human1.17889877
78TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17193877
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16942889
80* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16890925
81NANOG_19829295_ChIP-Seq_ESCs_Human1.16386681
82SOX2_19829295_ChIP-Seq_ESCs_Human1.16386681
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.16281174
84CIITA_25753668_ChIP-Seq_RAJI_Human1.15588071
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15346590
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.14664562
87STAT3_23295773_ChIP-Seq_U87_Human1.14534200
88TP53_22573176_ChIP-Seq_HFKS_Human1.13676803
89CDX2_22108803_ChIP-Seq_LS180_Human1.13377206
90* STAT3_18555785_Chip-Seq_ESCs_Mouse1.13115855
91KDM2B_26808549_Chip-Seq_REH_Human1.12739997
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12374242
93SCL_19346495_ChIP-Seq_HPC-7_Human1.12147690
94* P53_22387025_ChIP-Seq_ESCs_Mouse1.11726327
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11492659
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.11300662
97PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11288930
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10439982
99* NMYC_18555785_Chip-Seq_ESCs_Mouse1.10201416
100* SOX2_18555785_Chip-Seq_ESCs_Mouse1.07391007
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07339220
102ER_23166858_ChIP-Seq_MCF-7_Human1.07098302
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.07073120
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.06832820
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06484353
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06090681
107IRF1_19129219_ChIP-ChIP_H3396_Human1.05977828
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.05839168
109* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04174916
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03581121
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03280000
112SMAD4_21799915_ChIP-Seq_A2780_Human1.03243392
113* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03150393
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02712533
115EST1_17652178_ChIP-ChIP_JURKAT_Human1.01927880
116* CMYC_18555785_Chip-Seq_ESCs_Mouse1.01302148
117JUN_21703547_ChIP-Seq_K562_Human1.00930496
118* E2F1_18555785_Chip-Seq_ESCs_Mouse1.00610746
119CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00013261
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99475849
121* KLF4_18555785_Chip-Seq_ESCs_Mouse0.98174341
122* P300_18555785_Chip-Seq_ESCs_Mouse0.97357244
123* CTCF_18555785_Chip-Seq_ESCs_Mouse0.95972813
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94806833
125* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94404353
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94177734
127* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93976896
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93948597
129* ZFX_18555785_Chip-Seq_ESCs_Mouse0.93823231
130AR_25329375_ChIP-Seq_VCAP_Human0.93264244
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92499694
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91948661
133SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91522207
134KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89572525
135* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89174846
136* OCT4_18555785_Chip-Seq_ESCs_Mouse0.89012368
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88818458
138* TCF4_23295773_ChIP-Seq_U87_Human0.88021086
139RUNX1_26923725_Chip-Seq_HPCs_Mouse0.85943658
140PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85717780
141AR_21909140_ChIP-Seq_LNCAP_Human0.85496246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.68131026
2MP0002102_abnormal_ear_morphology4.50346178
3MP0006292_abnormal_olfactory_placode3.91822790
4MP0000569_abnormal_digit_pigmentation3.77214452
5MP0008877_abnormal_DNA_methylation2.61954063
6MP0010094_abnormal_chromosome_stability2.60353715
7MP0001188_hyperpigmentation2.60131082
8MP0003111_abnormal_nucleus_morphology2.39432074
9MP0005451_abnormal_body_composition2.35486512
10MP0002009_preneoplasia2.31686351
11MP0003880_abnormal_central_pattern2.28692901
12MP0003938_abnormal_ear_development2.25972160
13MP0001984_abnormal_olfaction2.22809969
14MP0003763_abnormal_thymus_physiology2.13606458
15MP0002396_abnormal_hematopoietic_system2.06026713
16MP0003693_abnormal_embryo_hatching2.04706596
17MP0003077_abnormal_cell_cycle2.02195174
18MP0008007_abnormal_cellular_replicative1.98831898
19MP0000427_abnormal_hair_cycle1.95684763
20MP0002249_abnormal_larynx_morphology1.94851835
21MP0001529_abnormal_vocalization1.94584247
22MP0005253_abnormal_eye_physiology1.93135693
23MP0003787_abnormal_imprinting1.85974303
24MP0002638_abnormal_pupillary_reflex1.85154039
25MP0005646_abnormal_pituitary_gland1.82446294
26MP0003890_abnormal_embryonic-extraembry1.78961597
27MP0003303_peritoneal_inflammation1.73674421
28MP0000383_abnormal_hair_follicle1.71163745
29MP0002653_abnormal_ependyma_morphology1.71162830
30MP0003195_calcinosis1.69425107
31MP0003123_paternal_imprinting1.67915373
32MP0001905_abnormal_dopamine_level1.65518264
33MP0000631_abnormal_neuroendocrine_gland1.63938688
34MP0004142_abnormal_muscle_tone1.62280031
35MP0001119_abnormal_female_reproductive1.60860977
36MP0002928_abnormal_bile_duct1.57501484
37MP0001486_abnormal_startle_reflex1.55315334
38MP0009278_abnormal_bone_marrow1.51537492
39MP0001929_abnormal_gametogenesis1.50601234
40MP0002210_abnormal_sex_determination1.50580295
41MP0008057_abnormal_DNA_replication1.47574691
42MP0005645_abnormal_hypothalamus_physiol1.47547774
43MP0009745_abnormal_behavioral_response1.46547947
44MP0009046_muscle_twitch1.45461240
45MP0003718_maternal_effect1.45220202
46MP0000372_irregular_coat_pigmentation1.41359933
47MP0002938_white_spotting1.39044192
48MP0000653_abnormal_sex_gland1.38906858
49MP0000778_abnormal_nervous_system1.38047988
50MP0004808_abnormal_hematopoietic_stem1.32940358
51MP0005409_darkened_coat_color1.32780454
52MP0004147_increased_porphyrin_level1.30316628
53MP0003121_genomic_imprinting1.29951161
54MP0003136_yellow_coat_color1.29921244
55MP0004043_abnormal_pH_regulation1.26773397
56MP0008058_abnormal_DNA_repair1.24783444
57MP0003699_abnormal_female_reproductive1.22679365
58MP0002736_abnormal_nociception_after1.21956543
59MP0003315_abnormal_perineum_morphology1.21544598
60MP0002751_abnormal_autonomic_nervous1.18535055
61MP0006072_abnormal_retinal_apoptosis1.14844725
62MP0001145_abnormal_male_reproductive1.13550116
63MP0002177_abnormal_outer_ear1.12694828
64MP0000015_abnormal_ear_pigmentation1.12520209
65MP0008872_abnormal_physiological_respon1.11622661
66MP0001545_abnormal_hematopoietic_system1.10516940
67MP0005397_hematopoietic_system_phenotyp1.10516940
68MP0004957_abnormal_blastocyst_morpholog1.10396041
69MP0001501_abnormal_sleep_pattern1.10382680
70MP0000566_synostosis1.08020281
71MP0008789_abnormal_olfactory_epithelium1.07856893
72MP0003937_abnormal_limbs/digits/tail_de1.07258870
73MP0000465_gastrointestinal_hemorrhage1.06300843
74MP0005171_absent_coat_pigmentation1.06140033
75MP0000462_abnormal_digestive_system1.06077584
76MP0000490_abnormal_crypts_of1.05969227
77MP0000049_abnormal_middle_ear1.04081132
78MP0005075_abnormal_melanosome_morpholog1.03822505
79MP0004742_abnormal_vestibular_system1.02850303
80MP0000647_abnormal_sebaceous_gland1.02443435
81MP0001324_abnormal_eye_pigmentation1.02303810
82MP0001502_abnormal_circadian_rhythm1.00570566
83MP0005389_reproductive_system_phenotype1.00313522
84MP0001293_anophthalmia1.00080645
85MP0009697_abnormal_copulation0.99940169
86MP0001963_abnormal_hearing_physiology0.99553388
87MP0005084_abnormal_gallbladder_morpholo0.99141631
88MP0010678_abnormal_skin_adnexa0.98440034
89MP0003698_abnormal_male_reproductive0.97867565
90MP0005310_abnormal_salivary_gland0.95785637
91MP0003567_abnormal_fetal_cardiomyocyte0.95703598
92MP0005394_taste/olfaction_phenotype0.94714514
93MP0005499_abnormal_olfactory_system0.94714514
94MP0003011_delayed_dark_adaptation0.94597290
95MP0002557_abnormal_social/conspecific_i0.94131579
96MP0005174_abnormal_tail_pigmentation0.93943318
97MP0001986_abnormal_taste_sensitivity0.93851471
98MP0000703_abnormal_thymus_morphology0.93836011
99MP0002277_abnormal_respiratory_mucosa0.92329866
100MP0005391_vision/eye_phenotype0.92089782
101MP0002398_abnormal_bone_marrow0.91265008
102MP0005381_digestive/alimentary_phenotyp0.90797836
103MP0000678_abnormal_parathyroid_gland0.90481172
104MP0003950_abnormal_plasma_membrane0.90268310
105MP0002161_abnormal_fertility/fecundity0.89662469
106MP0003786_premature_aging0.89635566
107MP0000026_abnormal_inner_ear0.89136197
108MP0005423_abnormal_somatic_nervous0.88801747
109MP0002138_abnormal_hepatobiliary_system0.88224879
110MP0004270_analgesia0.88049727
111MP0005195_abnormal_posterior_eye0.87651354
112MP0008995_early_reproductive_senescence0.87168102
113MP0002064_seizures0.86356354
114MP0005187_abnormal_penis_morphology0.85784160
115MP0005408_hypopigmentation0.85576464
116MP0006054_spinal_hemorrhage0.84301698
117MP0001663_abnormal_digestive_system0.84291702
118MP0003861_abnormal_nervous_system0.83884321
119MP0010386_abnormal_urinary_bladder0.83138539
120MP0002067_abnormal_sensory_capabilities0.82041956
121MP0004885_abnormal_endolymph0.81278726
122MP0000689_abnormal_spleen_morphology0.81062968
123MP0003635_abnormal_synaptic_transmissio0.80823904
124MP0004215_abnormal_myocardial_fiber0.79794226
125MP0006276_abnormal_autonomic_nervous0.79199038
126MP0005551_abnormal_eye_electrophysiolog0.78879581
127MP0001485_abnormal_pinna_reflex0.78728362
128MP0001764_abnormal_homeostasis0.77611349
129MP0005379_endocrine/exocrine_gland_phen0.77332405
130MP0002752_abnormal_somatic_nervous0.75964911
131MP0008961_abnormal_basal_metabolism0.75618192
132MP0002163_abnormal_gland_morphology0.74739072
133MP0000350_abnormal_cell_proliferation0.74137743
134MP0004859_abnormal_synaptic_plasticity0.73587227
135MP0002019_abnormal_tumor_incidence0.73304969
136MP0002184_abnormal_innervation0.71738908
137MP0002085_abnormal_embryonic_tissue0.71283089
138MP0001873_stomach_inflammation0.70973608
139MP0001968_abnormal_touch/_nociception0.70957763
140MP0008932_abnormal_embryonic_tissue0.70428894
141MP0001919_abnormal_reproductive_system0.69878893
142MP0002095_abnormal_skin_pigmentation0.68730671
143MP0002234_abnormal_pharynx_morphology0.68131421
144MP0000681_abnormal_thyroid_gland0.67140754
145MP0001697_abnormal_embryo_size0.66892641
146MP0009250_abnormal_appendicular_skeleto0.66410144
147MP0002063_abnormal_learning/memory/cond0.66295342
148MP0005671_abnormal_response_to0.65355450
149MP0002272_abnormal_nervous_system0.63123331
150MP0002572_abnormal_emotion/affect_behav0.61877062
151MP0002233_abnormal_nose_morphology0.61314996
152MP0004924_abnormal_behavior0.61089013
153MP0005386_behavior/neurological_phenoty0.61089013
154MP0001177_atelectasis0.60649524

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)5.52083222
2Chromsome breakage (HP:0040012)3.40654625
3Gastrointestinal infarctions (HP:0005244)3.36664641
4True hermaphroditism (HP:0010459)3.27320517
5Chronic hepatic failure (HP:0100626)3.09019845
6Patellar aplasia (HP:0006443)3.04436630
7Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98195268
8Aplastic anemia (HP:0001915)2.98068619
9Abnormal hair whorl (HP:0010721)2.93949882
10Hyperventilation (HP:0002883)2.86533308
11Aplasia/Hypoplasia of the patella (HP:0006498)2.84484592
12Stomach cancer (HP:0012126)2.70386831
13Pancreatic fibrosis (HP:0100732)2.68157279
14Nonprogressive disorder (HP:0003680)2.68069996
15Fair hair (HP:0002286)2.63315024
16Gaze-evoked nystagmus (HP:0000640)2.60623040
17Abnormality of chromosome stability (HP:0003220)2.59559155
18Abnormality of chromosome segregation (HP:0002916)2.58451033
19Abnormality of the renal cortex (HP:0011035)2.58058135
20Protruding tongue (HP:0010808)2.56528269
21Pancreatic cysts (HP:0001737)2.54361313
22Abnormal rod and cone electroretinograms (HP:0008323)2.53694315
23Type II lissencephaly (HP:0007260)2.53680484
24Birth length less than 3rd percentile (HP:0003561)2.51156100
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.49355038
26Capillary hemangiomas (HP:0005306)2.47942620
27Genital tract atresia (HP:0001827)2.45059124
28Acute myeloid leukemia (HP:0004808)2.43163476
29Abnormality of the renal medulla (HP:0100957)2.40919871
30Type 2 muscle fiber atrophy (HP:0003554)2.39572253
31Meckel diverticulum (HP:0002245)2.35343315
32Vaginal atresia (HP:0000148)2.34025257
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.32651519
34Myelodysplasia (HP:0002863)2.32500206
35Abnormality of midbrain morphology (HP:0002418)2.32218844
36Molar tooth sign on MRI (HP:0002419)2.32218844
37Abnormality of the preputium (HP:0100587)2.31547984
38Drooling (HP:0002307)2.30450460
39Abnormality of alanine metabolism (HP:0010916)2.30360319
40Hyperalaninemia (HP:0003348)2.30360319
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30360319
42Colon cancer (HP:0003003)2.29936461
43Gonadal dysgenesis (HP:0000133)2.29454474
44Nasal polyposis (HP:0100582)2.28507608
45Genetic anticipation (HP:0003743)2.27358823
46Intestinal atresia (HP:0011100)2.24295273
47Rectal prolapse (HP:0002035)2.21127355
48Facial hemangioma (HP:0000329)2.18328717
49Broad-based gait (HP:0002136)2.17740477
50Abnormality of the intervertebral disk (HP:0005108)2.17350595
51Bony spicule pigmentary retinopathy (HP:0007737)2.16761967
52Cystic liver disease (HP:0006706)2.16214006
53Abnormality of DNA repair (HP:0003254)2.15946466
54Neoplasm of the adrenal cortex (HP:0100641)2.14681331
55Adrenal hypoplasia (HP:0000835)2.14442109
56Abnormality of the ileum (HP:0001549)2.13944894
57Male infertility (HP:0003251)2.12868941
58Panhypogammaglobulinemia (HP:0003139)2.12642657
59Clubbing of toes (HP:0100760)2.11382522
60Excessive salivation (HP:0003781)2.11094013
61Absent speech (HP:0001344)2.10806714
62Flat capital femoral epiphysis (HP:0003370)2.06652220
63Muscle fiber atrophy (HP:0100295)2.05665063
64Optic nerve hypoplasia (HP:0000609)2.05376953
65Absent eyebrow (HP:0002223)2.05370871
66Volvulus (HP:0002580)2.04109247
67Pulmonary fibrosis (HP:0002206)2.03830728
68Embryonal neoplasm (HP:0002898)2.03341658
69Biliary tract neoplasm (HP:0100574)2.02444132
70Astigmatism (HP:0000483)2.02013323
71Oligodactyly (hands) (HP:0001180)2.01253336
72Papillary thyroid carcinoma (HP:0002895)2.00018752
73Inability to walk (HP:0002540)1.99503315
74Febrile seizures (HP:0002373)1.99394028
75Abnormality of the nasal mucosa (HP:0000433)1.98700056
76Hypochromic anemia (HP:0001931)1.96980475
77Midline defect of the nose (HP:0004122)1.95770648
78Nephronophthisis (HP:0000090)1.95713887
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95428344
80Renal cortical cysts (HP:0000803)1.95174703
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94455018
82Abnormality of the labia minora (HP:0012880)1.93935356
83Thickened helices (HP:0000391)1.93659139
84Acute lymphatic leukemia (HP:0006721)1.92630785
85Lissencephaly (HP:0001339)1.89645376
86Generalized hypopigmentation of hair (HP:0011358)1.89190442
87Progressive inability to walk (HP:0002505)1.88543417
88Cerebellar dysplasia (HP:0007033)1.86327131
89Agammaglobulinemia (HP:0004432)1.86156230
90Short foot (HP:0001773)1.85850550
91Nephroblastoma (Wilms tumor) (HP:0002667)1.85469591
92Aplasia/Hypoplasia of the fovea (HP:0008060)1.84585045
93Hypoplasia of the fovea (HP:0007750)1.84585045
94Sclerocornea (HP:0000647)1.82795021
95Dandy-Walker malformation (HP:0001305)1.82781591
96Postaxial foot polydactyly (HP:0001830)1.81963142
97Small hand (HP:0200055)1.81911334
98Preaxial hand polydactyly (HP:0001177)1.80775366
99Large for gestational age (HP:0001520)1.80756167
100Medial flaring of the eyebrow (HP:0010747)1.80430386
101Tented upper lip vermilion (HP:0010804)1.80426909
102Pendular nystagmus (HP:0012043)1.80293422
103Abolished electroretinogram (ERG) (HP:0000550)1.80044226
104Progressive cerebellar ataxia (HP:0002073)1.79673909
105Aplasia/Hypoplasia of the tongue (HP:0010295)1.79492430
106Nephrogenic diabetes insipidus (HP:0009806)1.79435421
107Abnormality of the pons (HP:0007361)1.79184474
108Abnormal lung lobation (HP:0002101)1.78766423
109Thyroiditis (HP:0100646)1.78574894
110Breast hypoplasia (HP:0003187)1.78405600
111Slow-growing hair (HP:0002217)1.78226680
112Abnormality of hair growth rate (HP:0011363)1.78226680
113Congenital hepatic fibrosis (HP:0002612)1.78086155
114Hypothermia (HP:0002045)1.78033269
115Small intestinal stenosis (HP:0012848)1.75992243
116Duodenal stenosis (HP:0100867)1.75992243
117Congenital stationary night blindness (HP:0007642)1.74931962
118Specific learning disability (HP:0001328)1.74700891
119Clumsiness (HP:0002312)1.74303125
120Postaxial hand polydactyly (HP:0001162)1.74052825
121Thyroid-stimulating hormone excess (HP:0002925)1.74031566
122Attenuation of retinal blood vessels (HP:0007843)1.73851885
123Abnormality of the carotid arteries (HP:0005344)1.73645671
124Embryonal renal neoplasm (HP:0011794)1.72845476
125Sloping forehead (HP:0000340)1.72781730
126Abnormality of the fovea (HP:0000493)1.72522373
127Widely spaced teeth (HP:0000687)1.71391782
128Chronic bronchitis (HP:0004469)1.71016634
129Occipital encephalocele (HP:0002085)1.70909210
130Supernumerary spleens (HP:0009799)1.70487395
131Abnormality of the duodenum (HP:0002246)1.70132169
132Optic nerve coloboma (HP:0000588)1.69746217
133Constricted visual fields (HP:0001133)1.69377672
134Abnormality of the columella (HP:0009929)1.68556180
135Broad foot (HP:0001769)1.68085083
136Ectopic kidney (HP:0000086)1.67945771
137Abnormality of the prostate (HP:0008775)1.66995677
138Duplicated collecting system (HP:0000081)1.66645401
139Anencephaly (HP:0002323)1.66482341
140Polydipsia (HP:0001959)1.66193190
141Abnormal drinking behavior (HP:0030082)1.66193190
142Aqueductal stenosis (HP:0002410)1.65778249
143Retrobulbar optic neuritis (HP:0100654)1.65072482
144Optic neuritis (HP:0100653)1.65072482
145Poikiloderma (HP:0001029)1.65072233
146Abnormal biliary tract physiology (HP:0012439)1.64965945
147Bile duct proliferation (HP:0001408)1.64965945
148Cupped ear (HP:0000378)1.64714155
149Abnormality of the renal collecting system (HP:0004742)1.64100147
150Aganglionic megacolon (HP:0002251)1.63654556
151Gait imbalance (HP:0002141)1.62967741
152Hypoplasia of the pons (HP:0012110)1.61995924
153Male pseudohermaphroditism (HP:0000037)1.61181972
154Gastrointestinal atresia (HP:0002589)1.60754901
155Narrow forehead (HP:0000341)1.60724215
156Poor coordination (HP:0002370)1.60208233
157Focal motor seizures (HP:0011153)1.59283620
158Congenital primary aphakia (HP:0007707)1.59092264
159Abnormal pancreas size (HP:0012094)1.58610895
160Aplasia/Hypoplasia of the spleen (HP:0010451)1.57946929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.29495674
2MUSK3.42761184
3MAP3K62.67297814
4TAOK32.56112243
5MAPK132.52463790
6WNK32.50395956
7MAP3K122.45041963
8CDK82.45035379
9BRAF2.40679729
10ZAK2.36323863
11PLK42.17443863
12BMPR1B2.16898587
13TRIM282.08803079
14TNIK2.04019388
15KSR12.03301596
16KIT1.89217783
17CCNB11.89081748
18CDK91.88755255
19MAP4K21.85994233
20RAF11.78872298
21MKNK21.78703163
22EEF2K1.77819010
23CDK31.75305405
24CDC71.72399271
25LATS11.71362165
26PINK11.63443361
27SGK21.62972362
28TTK1.59692274
29MAPKAPK51.58199265
30KSR21.58162232
31ERBB31.54994961
32PRKD21.54980040
33MKNK11.54276007
34SRPK11.53156992
35EIF2AK31.52907487
36BMPR21.51314424
37TLK11.47298890
38BRSK21.44096808
39CASK1.42926916
40CAMKK21.39440570
41MAP2K71.33086842
42BRD41.30411342
43CDK191.29002796
44PLK21.28299734
45BCR1.25983671
46MAP3K131.25877053
47DYRK21.24659416
48GRK11.23974511
49EPHA41.22928115
50CHEK21.20972023
51MOS1.20625713
52ERBB41.20209189
53FGFR21.16349102
54INSRR1.15941553
55TGFBR11.08163986
56SGK4941.07684600
57SGK2231.07684600
58STK38L1.07063231
59TEC1.05998695
60PAK31.04424952
61NLK1.03184074
62HIPK21.02932589
63CSNK1G11.01351703
64ACVR1B1.00488402
65CSNK1G20.97797085
66STK390.97653272
67NEK20.93498206
68MARK20.91902506
69IRAK10.91555259
70CSNK1G30.90486557
71STK100.90187115
72TAF10.87594374
73TAOK20.86403987
74NUAK10.84090113
75AKT30.83565523
76PLK10.82399521
77CAMK1D0.79516086
78TAOK10.77383673
79RPS6KA20.76597831
80SIK30.76277816
81WEE10.75741259
82STK30.75512196
83STK110.75493328
84RPS6KA40.74604258
85FLT30.73753482
86PRKCE0.73143769
87WNK40.73056233
88VRK10.72660802
89CSF1R0.72293773
90CAMK1G0.72021788
91NTRK20.71769007
92PNCK0.71515265
93PAK60.70822640
94BTK0.68569572
95MAP4K10.67583493
96DYRK30.67088290
97DYRK1A0.66562905
98ADRBK10.66365799
99TIE10.66125770
100CLK10.65866929
101PRPF4B0.65619128
102MAPKAPK30.65137456
103SGK30.65116356
104LATS20.64681109
105AURKB0.62931530
106CSNK1A1L0.62624911
107YES10.61763992
108PLK30.60397992
109ATR0.59944011
110PRKD30.59918789
111ARAF0.58859478
112MAP3K40.58170605
113MELK0.56992368
114ADRBK20.56357292
115TXK0.56269278
116EIF2AK20.55647051
117RPS6KB10.52441618
118ATM0.51273780
119OBSCN0.50625062
120FES0.50339102
121DAPK10.50069784
122JAK30.49373415
123MAP3K70.48881056
124RPS6KA50.48496997
125PIM10.47952894
126PRKCG0.47943224
127MAP3K80.45413449
128PTK2B0.44800926
129NME20.44776749
130CSNK1D0.44098089
131PASK0.43238035
132MARK30.42985666
133PBK0.42939724
134OXSR10.42357337
135EIF2AK10.41480432
136MARK10.39430665
137ITK0.38567583
138MST40.37810224
139CAMK10.37223972
140NTRK30.36983933
141SGK10.36350408
142PIK3CG0.36020159
143CAMK40.35071548
144TSSK60.34919340
145DAPK20.34810213
146PIK3CA0.34672007
147PRKAA20.34444177
148PRKAA10.33400931
149CAMK2A0.33285462

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.37445317
2DNA replication_Homo sapiens_hsa030302.82030196
3RNA degradation_Homo sapiens_hsa030182.67771860
4Selenocompound metabolism_Homo sapiens_hsa004502.38464979
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.35989520
6Basal transcription factors_Homo sapiens_hsa030222.30775924
7Ether lipid metabolism_Homo sapiens_hsa005652.30766838
8Homologous recombination_Homo sapiens_hsa034402.19800591
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13413452
10Non-homologous end-joining_Homo sapiens_hsa034502.13269271
11Nucleotide excision repair_Homo sapiens_hsa034202.08379859
12Base excision repair_Homo sapiens_hsa034102.06784012
13Butanoate metabolism_Homo sapiens_hsa006502.00371669
14Mismatch repair_Homo sapiens_hsa034301.98911941
15Fanconi anemia pathway_Homo sapiens_hsa034601.96423387
16RNA polymerase_Homo sapiens_hsa030201.94331689
17Circadian rhythm_Homo sapiens_hsa047101.85239875
18Taste transduction_Homo sapiens_hsa047421.72572292
19Phototransduction_Homo sapiens_hsa047441.66235090
20Propanoate metabolism_Homo sapiens_hsa006401.66012024
21Nitrogen metabolism_Homo sapiens_hsa009101.64622073
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64468997
23Primary immunodeficiency_Homo sapiens_hsa053401.64314677
24Ovarian steroidogenesis_Homo sapiens_hsa049131.49257190
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46173207
26Dorso-ventral axis formation_Homo sapiens_hsa043201.44299377
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.39676040
28One carbon pool by folate_Homo sapiens_hsa006701.39168944
29Serotonergic synapse_Homo sapiens_hsa047261.37970241
30Oocyte meiosis_Homo sapiens_hsa041141.36764984
31Glutamatergic synapse_Homo sapiens_hsa047241.32160447
32Nicotine addiction_Homo sapiens_hsa050331.31078933
33Pancreatic cancer_Homo sapiens_hsa052121.26480428
34Long-term depression_Homo sapiens_hsa047301.26070871
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25030068
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24419275
37Tryptophan metabolism_Homo sapiens_hsa003801.24239374
38Regulation of autophagy_Homo sapiens_hsa041401.23382083
39p53 signaling pathway_Homo sapiens_hsa041151.22897546
40Morphine addiction_Homo sapiens_hsa050321.22203563
41Spliceosome_Homo sapiens_hsa030401.20588093
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17680895
43Thyroid cancer_Homo sapiens_hsa052161.17534066
44GnRH signaling pathway_Homo sapiens_hsa049121.11354050
45ABC transporters_Homo sapiens_hsa020101.11139992
46mRNA surveillance pathway_Homo sapiens_hsa030151.08969282
47Notch signaling pathway_Homo sapiens_hsa043301.07716424
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06667414
49Purine metabolism_Homo sapiens_hsa002301.06420000
50Pyrimidine metabolism_Homo sapiens_hsa002401.03814633
51Long-term potentiation_Homo sapiens_hsa047201.01797496
52Colorectal cancer_Homo sapiens_hsa052100.99222255
53Circadian entrainment_Homo sapiens_hsa047130.99130085
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97125958
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97051840
56Lysine degradation_Homo sapiens_hsa003100.96467200
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.94785570
58Choline metabolism in cancer_Homo sapiens_hsa052310.94326504
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91771887
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90951545
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90001899
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.89683937
63Dopaminergic synapse_Homo sapiens_hsa047280.88996972
64Inositol phosphate metabolism_Homo sapiens_hsa005620.88589771
65Linoleic acid metabolism_Homo sapiens_hsa005910.87251137
66TGF-beta signaling pathway_Homo sapiens_hsa043500.85304849
67Olfactory transduction_Homo sapiens_hsa047400.83431516
68Non-small cell lung cancer_Homo sapiens_hsa052230.82876855
69Ras signaling pathway_Homo sapiens_hsa040140.82325365
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81047369
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80972046
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78599442
73Renal cell carcinoma_Homo sapiens_hsa052110.77012087
74B cell receptor signaling pathway_Homo sapiens_hsa046620.76959786
75Wnt signaling pathway_Homo sapiens_hsa043100.76651645
76MicroRNAs in cancer_Homo sapiens_hsa052060.73555115
77Cocaine addiction_Homo sapiens_hsa050300.72849200
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72634394
79RNA transport_Homo sapiens_hsa030130.72114437
80FoxO signaling pathway_Homo sapiens_hsa040680.71627529
81cAMP signaling pathway_Homo sapiens_hsa040240.71550982
82Systemic lupus erythematosus_Homo sapiens_hsa053220.71230946
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71058659
84Cholinergic synapse_Homo sapiens_hsa047250.71029551
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70659211
86Amphetamine addiction_Homo sapiens_hsa050310.68156379
87Chronic myeloid leukemia_Homo sapiens_hsa052200.67565521
88Herpes simplex infection_Homo sapiens_hsa051680.66555079
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65987778
90Hematopoietic cell lineage_Homo sapiens_hsa046400.65127131
91Oxytocin signaling pathway_Homo sapiens_hsa049210.64741381
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61886649
93Peroxisome_Homo sapiens_hsa041460.61427975
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61063404
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.60059914
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58959713
97Hepatitis B_Homo sapiens_hsa051610.58874680
98HTLV-I infection_Homo sapiens_hsa051660.57586028
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56901944
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56489862
101Endometrial cancer_Homo sapiens_hsa052130.56371094
102Pathways in cancer_Homo sapiens_hsa052000.55516961
103Prolactin signaling pathway_Homo sapiens_hsa049170.55499726
104Alcoholism_Homo sapiens_hsa050340.55390574
105GABAergic synapse_Homo sapiens_hsa047270.55317625
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.55267297
107Glycerolipid metabolism_Homo sapiens_hsa005610.55178407
108VEGF signaling pathway_Homo sapiens_hsa043700.54955592
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.54871161
110beta-Alanine metabolism_Homo sapiens_hsa004100.53994794
111Salivary secretion_Homo sapiens_hsa049700.53888376
112Protein export_Homo sapiens_hsa030600.53734005
113MAPK signaling pathway_Homo sapiens_hsa040100.53581326
114Hedgehog signaling pathway_Homo sapiens_hsa043400.53368932
115Insulin secretion_Homo sapiens_hsa049110.53367389
116Sphingolipid metabolism_Homo sapiens_hsa006000.53269323
117Melanogenesis_Homo sapiens_hsa049160.52631686
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52473641
119Asthma_Homo sapiens_hsa053100.51845294
120ErbB signaling pathway_Homo sapiens_hsa040120.50920843
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50256273
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.50004828
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49427796
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49127992
125Basal cell carcinoma_Homo sapiens_hsa052170.49032648
126Arachidonic acid metabolism_Homo sapiens_hsa005900.48851103
127Calcium signaling pathway_Homo sapiens_hsa040200.48671616
128Renin secretion_Homo sapiens_hsa049240.46695285
129T cell receptor signaling pathway_Homo sapiens_hsa046600.46219880
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45886862
131Platelet activation_Homo sapiens_hsa046110.45581542
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.44687586
133Axon guidance_Homo sapiens_hsa043600.44413880
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.41786294
135Type I diabetes mellitus_Homo sapiens_hsa049400.40496935
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39834266
137Melanoma_Homo sapiens_hsa052180.37216752
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.36123034
139Oxidative phosphorylation_Homo sapiens_hsa001900.36041831
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35709552
141Huntingtons disease_Homo sapiens_hsa050160.35333929

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