ANGPT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of endothelial cell differentiation (GO:0045601)7.44830442
2lymph vessel development (GO:0001945)6.64768653
3Notch signaling involved in heart development (GO:0061314)6.15188455
4negative regulation of complement activation (GO:0045916)5.93470344
5lymphangiogenesis (GO:0001946)5.93097091
6ventricular trabecula myocardium morphogenesis (GO:0003222)5.70625544
7vascular endothelial growth factor signaling pathway (GO:0038084)5.68633745
8glomerular filtration (GO:0003094)5.63133686
9blood vessel maturation (GO:0001955)5.27034717
10* negative regulation of blood vessel endothelial cell migration (GO:0043537)5.22668958
11renal filtration (GO:0097205)5.22442199
12heart trabecula morphogenesis (GO:0061384)5.09512911
13glomerular basement membrane development (GO:0032836)5.06331028
14sprouting angiogenesis (GO:0002040)4.81652624
15chondrocyte proliferation (GO:0035988)4.76786700
16negative regulation of protein activation cascade (GO:2000258)4.71307277
17glomerular visceral epithelial cell development (GO:0072015)4.68146845
18endothelium development (GO:0003158)4.51629400
19regulation of sarcomere organization (GO:0060297)4.37240776
20regulation of cell migration involved in sprouting angiogenesis (GO:0090049)4.19069004
21angiogenesis involved in wound healing (GO:0060055)4.18664552
22vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.17306734
23cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.12110934
24regulation of chemokine-mediated signaling pathway (GO:0070099)4.05271937
25retina vasculature morphogenesis in camera-type eye (GO:0061299)4.04970948
26glomerular epithelial cell development (GO:0072310)4.02359695
27trabecula morphogenesis (GO:0061383)4.01862347
28response to pheromone (GO:0019236)3.99786011
29positive regulation of vasculogenesis (GO:2001214)3.89909131
30negative regulation of catenin import into nucleus (GO:0035414)3.88065032
31endothelial cell morphogenesis (GO:0001886)3.84981218
32mesodermal cell differentiation (GO:0048333)3.79728393
33negative regulation of humoral immune response (GO:0002921)3.78718453
34artery smooth muscle contraction (GO:0014824)3.73874182
35positive regulation of odontogenesis (GO:0042482)3.72298315
36cell adhesion mediated by integrin (GO:0033627)3.71618226
37ovulation from ovarian follicle (GO:0001542)3.71299030
38histamine secretion (GO:0001821)3.62468486
39negative regulation of smooth muscle cell migration (GO:0014912)3.60739781
40positive regulation of keratinocyte differentiation (GO:0045618)3.58719994
41positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.57615972
42positive regulation of urine volume (GO:0035810)3.56143545
43glomerulus development (GO:0032835)3.41475607
44smooth muscle tissue development (GO:0048745)3.41124951
45positive regulation of smooth muscle cell migration (GO:0014911)3.40663849
46platelet dense granule organization (GO:0060155)3.40251474
47renal tubule morphogenesis (GO:0061333)3.38180381
48regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.35277568
49heart valve formation (GO:0003188)3.34636278
50regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.34159182
51regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.32369971
52basement membrane organization (GO:0071711)3.30649473
53atrial cardiac muscle cell action potential (GO:0086014)3.29846361
54regulation of integrin activation (GO:0033623)3.28269027
55phospholipid homeostasis (GO:0055091)3.25103385
56tonic smooth muscle contraction (GO:0014820)3.24538138
57vascular smooth muscle contraction (GO:0014829)3.23352119
58positive regulation of endothelial cell apoptotic process (GO:2000353)3.21620568
59wound healing, spreading of epidermal cells (GO:0035313)3.20896057
60positive regulation of p38MAPK cascade (GO:1900745)3.18190586
61negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.17482690
62endoderm formation (GO:0001706)3.15143191
63endothelial cell proliferation (GO:0001935)3.13260674
64nephron epithelium development (GO:0072009)3.12823656
65positive regulation of protein kinase C signaling (GO:0090037)3.12463538
66inositol phosphate-mediated signaling (GO:0048016)3.12242094
67regulation of establishment or maintenance of cell polarity (GO:0032878)3.08784067
68negative regulation of adherens junction organization (GO:1903392)3.08430097
69negative regulation of focal adhesion assembly (GO:0051895)3.08430097
70negative regulation of cell junction assembly (GO:1901889)3.08430097
71detection of molecule of bacterial origin (GO:0032490)3.07582160
72regulation of vasculogenesis (GO:2001212)3.03629232
73cell migration involved in heart development (GO:0060973)3.03592666
74* regulation of blood vessel endothelial cell migration (GO:0043535)3.03283515
75positive regulation of osteoblast proliferation (GO:0033690)2.99826709
76protein heterotrimerization (GO:0070208)2.99188038
77transcytosis (GO:0045056)2.96419468
78positive regulation of endothelial cell migration (GO:0010595)2.95457825
79multicellular organismal aging (GO:0010259)2.93671452
80lung vasculature development (GO:0060426)2.93621274
81histamine transport (GO:0051608)2.93293174
82calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.92456270
83regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.91079793
84positive regulation of glomerulus development (GO:0090193)2.89142835
85cell surface receptor signaling pathway involved in heart development (GO:0061311)2.89063892
86regulation of p38MAPK cascade (GO:1900744)2.85906684
87cellular response to BMP stimulus (GO:0071773)2.84974916
88response to BMP (GO:0071772)2.84974916
89endothelial tube morphogenesis (GO:0061154)2.84908574
90morphogenesis of an endothelium (GO:0003159)2.84908574
91regulation of smooth muscle cell differentiation (GO:0051150)2.84365340
92neuron remodeling (GO:0016322)2.82862389
93positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.81683170
94axon extension involved in axon guidance (GO:0048846)2.80731928
95neuron projection extension involved in neuron projection guidance (GO:1902284)2.80731928
96* negative regulation of epithelial cell migration (GO:0010633)2.80677428
97positive regulation of muscle hypertrophy (GO:0014742)2.80599365
98positive regulation of cardiac muscle hypertrophy (GO:0010613)2.80599365
99regulation of RIG-I signaling pathway (GO:0039535)2.80354097
100positive regulation of receptor recycling (GO:0001921)2.79302900
101regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.79222611
102surfactant homeostasis (GO:0043129)2.79184093
103positive regulation of endothelial cell differentiation (GO:0045603)2.76161364
104substrate-dependent cell migration (GO:0006929)2.75409114
105regulation of urine volume (GO:0035809)2.75360523
106* vasculature development (GO:0001944)2.74332984
107ganglion development (GO:0061548)2.74183136
108* negative regulation of endothelial cell migration (GO:0010596)2.72694740
109regulation of establishment of cell polarity (GO:2000114)2.71998232
110regulation of integrin-mediated signaling pathway (GO:2001044)2.71626748
111cell proliferation involved in metanephros development (GO:0072203)2.71214954
112labyrinthine layer development (GO:0060711)2.71110676
113fibroblast migration (GO:0010761)2.70905141
114vasculogenesis (GO:0001570)2.69926823
115regulation of smooth muscle cell migration (GO:0014910)2.68953973
116neural crest cell development (GO:0014032)2.68378379
117regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.67590580
118endothelial cell differentiation (GO:0045446)2.65965963
119protein localization to cell surface (GO:0034394)2.65740140
120patterning of blood vessels (GO:0001569)2.65282277
121hippo signaling (GO:0035329)2.64024586
122collagen fibril organization (GO:0030199)2.63986060
123negative regulation of myoblast differentiation (GO:0045662)2.63867020
124cell proliferation involved in kidney development (GO:0072111)2.63208033
125embryonic heart tube development (GO:0035050)2.62768892
126regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.60851965
127regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.58266839
128negative regulation of mast cell activation (GO:0033004)2.58212181
129* regulation of endothelial cell migration (GO:0010594)2.58180762
130* angiogenesis (GO:0001525)2.57719527
131positive regulation of cell size (GO:0045793)2.57671270
132artery development (GO:0060840)2.57642452
133branching involved in salivary gland morphogenesis (GO:0060445)2.57620045
134substrate adhesion-dependent cell spreading (GO:0034446)2.57483192
135phasic smooth muscle contraction (GO:0014821)2.56938716
136venous blood vessel morphogenesis (GO:0048845)2.55088190
137cardiac ventricle morphogenesis (GO:0003208)2.54487066
138positive regulation of cardiac muscle cell differentiation (GO:2000727)2.54244608
139negative regulation of transcription regulatory region DNA binding (GO:2000678)2.54145921
140epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.53990042
141negative regulation of axon extension involved in axon guidance (GO:0048843)2.52518266
142negative regulation of systemic arterial blood pressure (GO:0003085)2.52144928
143endocardial cushion morphogenesis (GO:0003203)2.51774472
144positive regulation of epithelial to mesenchymal transition (GO:0010718)2.51442543
145regulation of mesoderm development (GO:2000380)2.51213793
146aorta morphogenesis (GO:0035909)2.51135329
147negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50915806
148negative regulation of Rho protein signal transduction (GO:0035024)2.48945198
149positive regulation of DNA biosynthetic process (GO:2000573)2.48937697
150mesenchymal cell development (GO:0014031)2.48645144
151response to fluid shear stress (GO:0034405)2.48575058
152positive regulation of heart rate (GO:0010460)2.48153848
153cell migration involved in sprouting angiogenesis (GO:0002042)2.47887236
154regulation of glomerular filtration (GO:0003093)2.47307814
155platelet-derived growth factor receptor signaling pathway (GO:0048008)2.46685727
156positive regulation of endothelial cell proliferation (GO:0001938)2.46166746
157Notch receptor processing (GO:0007220)2.46162400
158mesenchymal-epithelial cell signaling (GO:0060638)2.42896989
159negative regulation of endothelial cell proliferation (GO:0001937)2.41087002
160blood vessel endothelial cell migration (GO:0043534)2.37265169
161fibril organization (GO:0097435)2.35847961
162wound healing, spreading of cells (GO:0044319)2.35789317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.35832587
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.94728737
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.07822273
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.05917566
5VDR_22108803_ChIP-Seq_LS180_Human3.19114055
6* GATA2_21666600_ChIP-Seq_HMVEC_Human3.09947191
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.95080442
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.92645126
9ZNF274_21170338_ChIP-Seq_K562_Hela2.88129496
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.85639570
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.69776456
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.68749254
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.51133398
14CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.48724278
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40960558
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38840808
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34001422
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.32465490
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.28959967
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28508803
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.27529162
22P300_19829295_ChIP-Seq_ESCs_Human2.22198140
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14808069
24* CJUN_26792858_Chip-Seq_BT549_Human2.07200322
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03044185
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02172540
27CLOCK_20551151_ChIP-Seq_293T_Human1.95487937
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92886560
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.92657829
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91774277
31BCAT_22108803_ChIP-Seq_LS180_Human1.91557413
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.87947162
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87397956
34SALL4_18804426_ChIP-ChIP_XEN_Mouse1.82363189
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.81296129
36EWS_26573619_Chip-Seq_HEK293_Human1.80973312
37TAF15_26573619_Chip-Seq_HEK293_Human1.77670616
38BRD4_25478319_ChIP-Seq_HGPS_Human1.76986828
39FUS_26573619_Chip-Seq_HEK293_Human1.76150857
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75643676
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74273583
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70023568
43SOX2_20726797_ChIP-Seq_SW620_Human1.67089598
44* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64842492
45IGF1R_20145208_ChIP-Seq_DFB_Human1.64610855
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.63549072
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63361946
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62580183
49SMAD4_21799915_ChIP-Seq_A2780_Human1.60919230
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58925876
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57880953
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57324704
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57005132
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57005132
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56319035
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56319035
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56170604
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55008585
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54963671
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53162460
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50664480
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50510188
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49993578
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48003731
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45853247
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43612943
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43381536
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41884776
69VDR_24787735_ChIP-Seq_THP-1_Human1.39058740
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37757257
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37654327
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37325306
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.37021933
74AR_21572438_ChIP-Seq_LNCaP_Human1.36457947
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36221229
76RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34424913
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34424913
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.32636733
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32024216
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31906992
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30942807
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.30797964
83AR_25329375_ChIP-Seq_VCAP_Human1.30701844
84EZH2_22144423_ChIP-Seq_EOC_Human1.30691383
85ER_23166858_ChIP-Seq_MCF-7_Human1.30030682
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.29860725
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29330899
88* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29002369
89CBP_20019798_ChIP-Seq_JUKART_Human1.27617794
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27617794
91RUNX2_22187159_ChIP-Seq_PCA_Human1.27545951
92TCF4_22108803_ChIP-Seq_LS180_Human1.26242466
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26128960
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.25761244
95JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24550911
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23812130
97STAT3_23295773_ChIP-Seq_U87_Human1.20903634
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.20753360
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.20525780
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.19926202
101RNF2_27304074_Chip-Seq_NSC_Mouse1.19912273
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19831713
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19395089
104EZH2_27304074_Chip-Seq_ESCs_Mouse1.18864674
105MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18705559
106AHR_22903824_ChIP-Seq_MCF-7_Human1.18379804
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18274867
108* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18213243
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17802031
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.17788991
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16604529
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15647091
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14547309
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14354309
115KDM2B_26808549_Chip-Seq_REH_Human1.13844107
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.13825960
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13408750
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12842470
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12078885
120* SMAD4_21741376_ChIP-Seq_EPCs_Human1.12029990
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11509052
122TP53_16413492_ChIP-PET_HCT116_Human1.11459951
123TCF4_23295773_ChIP-Seq_U87_Human1.11307438
124TP53_18474530_ChIP-ChIP_U2OS_Human1.11168974
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10755555
126* CDX2_22108803_ChIP-Seq_LS180_Human1.10352838
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08872619
128TBX20_22328084_ChIP-Seq_HEART_Mouse1.08760031
129TBX20_22080862_ChIP-Seq_HEART_Mouse1.08760031
130EED_16625203_ChIP-ChIP_MESCs_Mouse1.07656412
131IRF8_22096565_ChIP-ChIP_GC-B_Human1.07422684
132* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07387261
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06481430
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05797364
135* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05718750
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05693119
137ARNT_22903824_ChIP-Seq_MCF-7_Human1.05179253
138STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05089448
139* SMAD3_21741376_ChIP-Seq_EPCs_Human1.04746252
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03284004
141TCF4_18268006_ChIP-ChIP_LS174T_Human1.03076486
142* SOX2_19829295_ChIP-Seq_ESCs_Human1.03002476
143* NANOG_19829295_ChIP-Seq_ESCs_Human1.03002476
144PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01525836
145GBX2_23144817_ChIP-Seq_PC3_Human1.00360086
146* SMAD3_21741376_ChIP-Seq_HESCs_Human0.99317222
147RXR_22108803_ChIP-Seq_LS180_Human0.98431561
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97357042
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94974971
150AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93891597
151STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93458819
152* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92123791
153SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91753695
154* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90626083
155FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89449598
156SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88786914
157PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88530902
158ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88319324
159WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88092943
160CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86566193
161* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85407282
162RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84874085
163* ISL1_27105846_Chip-Seq_CPCs_Mouse0.84832626
164PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84433350
165ELK3_25401928_ChIP-Seq_HUVEC_Human0.83848280
166RUNX_20019798_ChIP-Seq_JUKART_Human0.83786474
167JUN_21703547_ChIP-Seq_K562_Human0.82342245
168* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81699768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.24229457
2MP0006054_spinal_hemorrhage4.85251512
3MP0008438_abnormal_cutaneous_collagen4.43970590
4* MP0001879_abnormal_lymphatic_vessel4.09997828
5MP0004272_abnormal_basement_membrane3.79768135
6MP0005623_abnormal_meninges_morphology3.03745207
7MP0005503_abnormal_tendon_morphology2.93451085
8MP0003279_aneurysm2.89666641
9MP0000767_abnormal_smooth_muscle2.81116572
10MP0005084_abnormal_gallbladder_morpholo2.59437721
11MP0003724_increased_susceptibility_to2.54663824
12MP0001958_emphysema2.54625416
13MP0005171_absent_coat_pigmentation2.36121952
14MP0003045_fibrosis2.34341406
15MP0003566_abnormal_cell_adhesion2.25760612
16MP0002877_abnormal_melanocyte_morpholog2.08938619
17MP0005167_abnormal_blood-brain_barrier2.07066287
18MP0004215_abnormal_myocardial_fiber1.97642790
19MP0003828_pulmonary_edema1.96957381
20MP0004145_abnormal_muscle_electrophysio1.86731412
21MP0003941_abnormal_skin_development1.81489353
22MP0004885_abnormal_endolymph1.80179804
23MP0005275_abnormal_skin_tensile1.75790225
24MP0002127_abnormal_cardiovascular_syste1.73515956
25MP0000013_abnormal_adipose_tissue1.71834734
26MP0003091_abnormal_cell_migration1.70129680
27MP0005257_abnormal_intraocular_pressure1.65094294
28MP0002332_abnormal_exercise_endurance1.63063097
29MP0005508_abnormal_skeleton_morphology1.62732269
30MP0001542_abnormal_bone_strength1.62293828
31MP0005187_abnormal_penis_morphology1.60836329
32MP0003300_gastrointestinal_ulcer1.59365881
33MP0004084_abnormal_cardiac_muscle1.55357974
34MP0002295_abnormal_pulmonary_circulatio1.53129867
35MP0000249_abnormal_blood_vessel1.50301281
36MP0004147_increased_porphyrin_level1.45624532
37MP0000049_abnormal_middle_ear1.42195849
38MP0002128_abnormal_blood_circulation1.41669801
39MP0006276_abnormal_autonomic_nervous1.41439330
40MP0005164_abnormal_response_to1.38160088
41MP0001915_intracranial_hemorrhage1.37980377
42MP0005595_abnormal_vascular_smooth1.34663217
43MP0006138_congestive_heart_failure1.33349698
44MP0002638_abnormal_pupillary_reflex1.31352316
45MP0003195_calcinosis1.31095466
46MP0009278_abnormal_bone_marrow1.30926477
47MP0002736_abnormal_nociception_after1.25731844
48* MP0001614_abnormal_blood_vessel1.25225330
49MP0009379_abnormal_foot_pigmentation1.25012754
50* MP0002925_abnormal_cardiovascular_devel1.24612181
51MP0009697_abnormal_copulation1.24205351
52MP0005023_abnormal_wound_healing1.20122870
53MP0000516_abnormal_urinary_system1.19340366
54MP0005367_renal/urinary_system_phenotyp1.19340366
55MP0002396_abnormal_hematopoietic_system1.15223451
56MP0001851_eye_inflammation1.15123159
57MP0004085_abnormal_heartbeat1.14209070
58MP0000003_abnormal_adipose_tissue1.13536640
59MP0001188_hyperpigmentation1.13298024
60MP0002998_abnormal_bone_remodeling1.12095747
61MP0002933_joint_inflammation1.11812178
62MP0002938_white_spotting1.09080966
63MP0004883_abnormal_blood_vessel1.08981890
64MP0005408_hypopigmentation1.08839949
65MP0003890_abnormal_embryonic-extraembry1.07630431
66MP0003567_abnormal_fetal_cardiomyocyte1.06521653
67MP0002168_other_aberrant_phenotype1.06350894
68MP0003448_altered_tumor_morphology1.05144006
69MP0004484_altered_response_of1.02295224
70MP0005390_skeleton_phenotype1.01980479
71MP0001968_abnormal_touch/_nociception1.01666213
72MP0005165_increased_susceptibility_to1.00503399
73MP0003119_abnormal_digestive_system0.99667326
74MP0002102_abnormal_ear_morphology0.96417809
75MP0004134_abnormal_chest_morphology0.96012811
76MP0003950_abnormal_plasma_membrane0.95619588
77MP0000465_gastrointestinal_hemorrhage0.93602703
78MP0009384_cardiac_valve_regurgitation0.93016166
79MP0001293_anophthalmia0.93001120
80MP0002060_abnormal_skin_morphology0.92764085
81MP0003705_abnormal_hypodermis_morpholog0.92366435
82MP0009250_abnormal_appendicular_skeleto0.90117011
83MP0000343_altered_response_to0.89987749
84MP0000569_abnormal_digit_pigmentation0.89549965
85MP0003880_abnormal_central_pattern0.88881912
86MP0005551_abnormal_eye_electrophysiolog0.88759618
87MP0003935_abnormal_craniofacial_develop0.86763729
88MP0008775_abnormal_heart_ventricle0.85878521
89MP0000163_abnormal_cartilage_morphology0.85407896
90MP0002837_dystrophic_cardiac_calcinosis0.84916231
91MP0000733_abnormal_muscle_development0.84831193
92MP0003878_abnormal_ear_physiology0.84830186
93MP0005377_hearing/vestibular/ear_phenot0.84830186
94MP0001986_abnormal_taste_sensitivity0.83941986
95MP0005620_abnormal_muscle_contractility0.83715322
96MP0003385_abnormal_body_wall0.83564766
97MP0002108_abnormal_muscle_morphology0.83210306
98MP0001533_abnormal_skeleton_physiology0.82445105
99MP0003283_abnormal_digestive_organ0.82225497
100MP0005670_abnormal_white_adipose0.81535768
101MP0000749_muscle_degeneration0.81317770
102MP0001270_distended_abdomen0.81059894
103MP0001175_abnormal_lung_morphology0.80458545
104MP0000230_abnormal_systemic_arterial0.80049720
105MP0002138_abnormal_hepatobiliary_system0.79003753
106MP0005253_abnormal_eye_physiology0.78314275
107MP0002115_abnormal_skeleton_extremities0.77500088
108MP0000266_abnormal_heart_morphology0.77180735
109MP0009046_muscle_twitch0.76361787
110MP0005397_hematopoietic_system_phenotyp0.75298663
111MP0001545_abnormal_hematopoietic_system0.75298663
112MP0002896_abnormal_bone_mineralization0.75266804
113MP0005391_vision/eye_phenotype0.74997274
114MP0005388_respiratory_system_phenotype0.74874360
115MP0002133_abnormal_respiratory_system0.74874360
116MP0000858_altered_metastatic_potential0.74454222
117MP0002272_abnormal_nervous_system0.74047924
118MP0002928_abnormal_bile_duct0.73915957
119MP0010630_abnormal_cardiac_muscle0.73523933
120MP0002972_abnormal_cardiac_muscle0.73506570
121MP0009333_abnormal_splenocyte_physiolog0.73257597
122MP0002086_abnormal_extraembryonic_tissu0.72401962
123MP0009053_abnormal_anal_canal0.72040222
124MP0004036_abnormal_muscle_relaxation0.70850089
125MP0001486_abnormal_startle_reflex0.70798119
126MP0002113_abnormal_skeleton_development0.70111399
127MP0001544_abnormal_cardiovascular_syste0.69469737
128MP0005385_cardiovascular_system_phenoty0.69469737
129MP0003943_abnormal_hepatobiliary_system0.69444931
130MP0003303_peritoneal_inflammation0.68602708
131MP0003172_abnormal_lysosome_physiology0.68389063
132* MP0001784_abnormal_fluid_regulation0.68292052
133MP0004133_heterotaxia0.67482664
134MP0000778_abnormal_nervous_system0.66685238
135MP0000537_abnormal_urethra_morphology0.66535951
136* MP0005195_abnormal_posterior_eye0.63273508
137MP0002088_abnormal_embryonic_growth/wei0.62428773
138MP0003984_embryonic_growth_retardation0.60508412
139MP0003633_abnormal_nervous_system0.60323469
140MP0000613_abnormal_salivary_gland0.59142498
141MP0002092_abnormal_eye_morphology0.58563639
142MP0001501_abnormal_sleep_pattern0.57544855
143MP0006072_abnormal_retinal_apoptosis0.54513756
144MP0000372_irregular_coat_pigmentation0.53622133
145MP0004043_abnormal_pH_regulation0.53025083
146MP0005197_abnormal_uvea_morphology0.51602903
147MP0005085_abnormal_gallbladder_physiolo0.50328697
148MP0005330_cardiomyopathy0.49396409
149MP0003948_abnormal_gas_homeostasis0.47931010
150MP0000647_abnormal_sebaceous_gland0.47669306
151MP0001756_abnormal_urination0.46811894
152MP0002751_abnormal_autonomic_nervous0.45444395
153MP0008877_abnormal_DNA_methylation0.44951839
154MP0005409_darkened_coat_color0.44775308
155MP0009745_abnormal_behavioral_response0.44664538
156MP0002697_abnormal_eye_size0.44575473
157MP0001502_abnormal_circadian_rhythm0.44065394
158MP0003631_nervous_system_phenotype0.43245914

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.37204129
2Hemiplegia (HP:0002301)5.10446402
3Tetraparesis (HP:0002273)5.06768182
4Stenosis of the external auditory canal (HP:0000402)4.82943781
5Nonimmune hydrops fetalis (HP:0001790)4.56905775
6Limb dystonia (HP:0002451)4.38878052
7Cerebral hemorrhage (HP:0001342)4.23822879
8Porencephaly (HP:0002132)4.15924919
9Aortic aneurysm (HP:0004942)3.84902907
10Distal lower limb muscle weakness (HP:0009053)3.83658396
11Hemiparesis (HP:0001269)3.74445199
12Wrist flexion contracture (HP:0001239)3.71487199
13Hematochezia (HP:0002573)3.71274775
14Exotropia (HP:0000577)3.68524943
15Cerebral aneurysm (HP:0004944)3.31232354
16Scotoma (HP:0000575)3.30348067
17Broad metatarsal (HP:0001783)3.26614285
18Aortic dissection (HP:0002647)3.26192780
19Anterior segment dysgenesis (HP:0007700)3.23839107
20Pulmonary artery stenosis (HP:0004415)3.12638853
21Increased corneal curvature (HP:0100692)3.04233373
22Keratoconus (HP:0000563)3.04233373
23Pancreatic cysts (HP:0001737)3.00873860
24Capillary hemangiomas (HP:0005306)3.00350203
25Hyporeflexia of lower limbs (HP:0002600)2.99973901
26Cervical subluxation (HP:0003308)2.99264024
27Spondylolisthesis (HP:0003302)2.95212362
28Segmental peripheral demyelination/remyelination (HP:0003481)2.95200285
29Abnormality of the vitreous humor (HP:0004327)2.95156900
30Polycythemia (HP:0001901)2.92995831
31Vascular tortuosity (HP:0004948)2.92452991
32Protrusio acetabuli (HP:0003179)2.90553419
33Shallow orbits (HP:0000586)2.86881939
34Occipital encephalocele (HP:0002085)2.84322364
35Soft skin (HP:0000977)2.81800131
36Hypochromic microcytic anemia (HP:0004840)2.79235919
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.79068784
38Osteolytic defects of the hand bones (HP:0009699)2.79068784
39Abnormality of the nasal septum (HP:0000419)2.76906134
40Type II lissencephaly (HP:0007260)2.73905923
41Myotonia (HP:0002486)2.73480844
42Amblyopia (HP:0000646)2.72742626
43Subacute progressive viral hepatitis (HP:0006572)2.71367232
44Delayed CNS myelination (HP:0002188)2.70982511
45Hyperventilation (HP:0002883)2.69516627
46Abnormality of midbrain morphology (HP:0002418)2.63138537
47Molar tooth sign on MRI (HP:0002419)2.63138537
48Distal lower limb amyotrophy (HP:0008944)2.63113011
49Hydroxyprolinuria (HP:0003080)2.61295002
50Abnormality of proline metabolism (HP:0010907)2.61295002
51Asymmetry of the thorax (HP:0001555)2.61164909
52Abnormality of the vasculature of the conjunctiva (HP:0008054)2.59628255
53Atrophic scars (HP:0001075)2.51746801
54Pancreatic fibrosis (HP:0100732)2.51128348
55Chondrocalcinosis (HP:0000934)2.50210195
56Esophageal varix (HP:0002040)2.50001409
57Absent frontal sinuses (HP:0002688)2.48776896
58Aplasia cutis congenita (HP:0001057)2.47224639
59Increased connective tissue (HP:0009025)2.45155224
60Abnormality of the renal medulla (HP:0100957)2.44610612
61Wormian bones (HP:0002645)2.42078291
62Abnormality of Sharpey fibers (HP:0100685)2.41289504
63Nephronophthisis (HP:0000090)2.38571133
64Delayed closure of the anterior fontanelle (HP:0001476)2.38175891
65Focal segmental glomerulosclerosis (HP:0000097)2.37049269
66Broad-based gait (HP:0002136)2.36692888
67Blue sclerae (HP:0000592)2.36083699
68Hemorrhage of the eye (HP:0011885)2.35222721
69True hermaphroditism (HP:0010459)2.32780878
70Lower limb amyotrophy (HP:0007210)2.28743815
71Adactyly (HP:0009776)2.27101772
72Mesangial abnormality (HP:0001966)2.26130162
73Abnormality of the renal cortex (HP:0011035)2.24963634
74Persistence of primary teeth (HP:0006335)2.22541866
75Short nail (HP:0001799)2.22516524
76Disproportionate short-trunk short stature (HP:0003521)2.19893523
77Portal hypertension (HP:0001409)2.19396011
78Sclerocornea (HP:0000647)2.19172984
79Ankle contracture (HP:0006466)2.18471926
80Short hallux (HP:0010109)2.18083256
81Absent speech (HP:0001344)2.17681271
82Fibular aplasia (HP:0002990)2.15010168
83Medial flaring of the eyebrow (HP:0010747)2.14839525
84Bulbous nose (HP:0000414)2.14016225
85Visceral angiomatosis (HP:0100761)2.13472551
86Absent hand (HP:0004050)2.10981871
87Submucous cleft hard palate (HP:0000176)2.10803598
88Lymphangioma (HP:0100764)2.07400914
89Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.04193151
90Congenital stationary night blindness (HP:0007642)2.03217222
91Cavernous hemangioma (HP:0001048)2.02994262
92Prominent supraorbital ridges (HP:0000336)2.02298209
93Cortical dysplasia (HP:0002539)2.02161849
94Abnormality of the frontal sinuses (HP:0002687)2.01904959
95Fragile skin (HP:0001030)2.00063937
96Arterial tortuosity (HP:0005116)1.99653656
97Congenital hepatic fibrosis (HP:0002612)1.99257720
98Overgrowth (HP:0001548)1.98679889
99Bifid uvula (HP:0000193)1.98575150
100Abnormality of the hepatic vasculature (HP:0006707)1.97667415
101Bladder diverticulum (HP:0000015)1.97505936
102Spinal rigidity (HP:0003306)1.97180124
103Dilatation of the ascending aorta (HP:0005111)1.97143992
104Aortic valve stenosis (HP:0001650)1.96636661
105Lissencephaly (HP:0001339)1.95439280
106Pachygyria (HP:0001302)1.95344212
107Right ventricular cardiomyopathy (HP:0011663)1.95310155
108Meningioma (HP:0002858)1.94576550
109Systemic lupus erythematosus (HP:0002725)1.91876003
110Absent eyebrow (HP:0002223)1.91107730
111Abolished electroretinogram (ERG) (HP:0000550)1.90945109
112Abnormal hemoglobin (HP:0011902)1.90129728
113Aneurysm (HP:0002617)1.89852441
114Hypoplasia of the iris (HP:0007676)1.88892831
115Congenital, generalized hypertrichosis (HP:0004540)1.88858462
116Abnormality of the anterior chamber (HP:0000593)1.88396542
117Hemangiomatosis (HP:0007461)1.87799403
118Fair hair (HP:0002286)1.87359738
119Aplasia/hypoplasia of the uterus (HP:0008684)1.85832715
120Inability to walk (HP:0002540)1.85639272
121Limb-girdle muscle atrophy (HP:0003797)1.85022003
122Joint laxity (HP:0001388)1.84902433
123Myocardial infarction (HP:0001658)1.84638233
124Hyperlipoproteinemia (HP:0010980)1.84604544
125Aplasia/Hypoplasia of the hallux (HP:0008362)1.84108197
126Scapular winging (HP:0003691)1.83826014
127Short 4th metacarpal (HP:0010044)1.83369880
128Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83369880
129Spontaneous hematomas (HP:0007420)1.83363926
130Hypoalbuminemia (HP:0003073)1.83029186
131Abnormal albumin level (HP:0012116)1.83029186
132Hypokalemic alkalosis (HP:0001949)1.82639463
133Follicular hyperkeratosis (HP:0007502)1.82032340
134Limited hip movement (HP:0008800)1.81726285
135Lymphedema (HP:0001004)1.81023072
136Enlarged penis (HP:0000040)1.80819076
137Glomerulosclerosis (HP:0000096)1.79898330
138Tubular atrophy (HP:0000092)1.79277314
139Narrow palate (HP:0000189)1.77852790
140Supraventricular arrhythmia (HP:0005115)1.77230296
141Ulnar claw (HP:0001178)1.76440579
142Polydipsia (HP:0001959)1.76398878
143Abnormal drinking behavior (HP:0030082)1.76398878
144Mesomelia (HP:0003027)1.75981548
145Coronal craniosynostosis (HP:0004440)1.75798024
146Vertebral clefting (HP:0008428)1.75646597
147Mitral valve prolapse (HP:0001634)1.74718552
148Abnormality of dentin (HP:0010299)1.74607179
149Delayed cranial suture closure (HP:0000270)1.74560061
150Attenuation of retinal blood vessels (HP:0007843)1.73673886
151Abnormality of chloride homeostasis (HP:0011422)1.72656304
152Hyperactive renin-angiotensin system (HP:0000841)1.72645975
153EMG: myopathic abnormalities (HP:0003458)1.72285340
154Aplasia/Hypoplasia of the tibia (HP:0005772)1.71852500
155Hypothermia (HP:0002045)1.71670696
156Renal hypoplasia (HP:0000089)1.71616462
157Conjunctival telangiectasia (HP:0000524)1.71163152
158Purpura (HP:0000979)1.71074955
159Chorioretinal atrophy (HP:0000533)1.70725250
160Abnormal delivery (HP:0001787)1.69854741
161Syringomyelia (HP:0003396)1.69550569
162Spinal cord lesions (HP:0100561)1.69550569
163Skull defect (HP:0001362)1.68782177
164Hematuria (HP:0000790)1.68692962
165Atonic seizures (HP:0010819)1.68622583
166Dandy-Walker malformation (HP:0001305)1.65996209
167White forelock (HP:0002211)1.65469178
168Polymicrogyria (HP:0002126)1.65454056
169Stroke (HP:0001297)1.65332363
170Shawl scrotum (HP:0000049)1.65207725
171Polyuria (HP:0000103)1.65154619
172Mitral stenosis (HP:0001718)1.65107872
173Retinal dysplasia (HP:0007973)1.64639700
174Hip contracture (HP:0003273)1.64391108
175Abnormality of the nasal mucosa (HP:0000433)1.63850024
176Cystic liver disease (HP:0006706)1.62668441
177Full cheeks (HP:0000293)1.62614684
178Non-midline cleft lip (HP:0100335)1.62602938
179Spinal muscular atrophy (HP:0007269)1.61838232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.13011645
2RIPK15.53741849
3TIE13.71150305
4PIM23.03824993
5TGFBR22.73051801
6ZAK2.66808322
7MAP3K122.28973513
8AKT32.19863417
9PDGFRA2.13047707
10TGFBR12.10720336
11FER2.09708341
12PDK21.90613356
13LATS11.87276629
14STK391.83916289
15EPHB21.83288246
16ERN11.76962041
17TRPM71.67970253
18MAP3K141.67516064
19MYLK1.67030462
20PTK61.62047944
21TSSK61.55950364
22KIT1.51508567
23EPHA31.47137068
24PAK41.45143859
25PTK2B1.42713096
26FLT31.40442557
27GRK11.31636626
28FRK1.30191762
29NUAK11.29806943
30ACVR1B1.27836988
31PNCK1.21057507
32MAP4K21.18265750
33NEK91.16401745
34ERBB21.15484373
35ADRBK21.12839102
36MAP3K31.09511430
37PDGFRB1.08982767
38PLK21.06586377
39CDK81.01627305
40DDR20.99932452
41PTK20.98595397
42MARK30.98214282
43CAMK1G0.97235566
44CASK0.94982323
45BMPR1B0.94715051
46ERBB30.93733907
47PKN20.93185304
48PAK20.92136964
49MET0.92003174
50NEK60.91165004
51CDK60.90717475
52TTN0.89735221
53CHUK0.88560644
54MAPK130.86934194
55DMPK0.86048930
56PINK10.84353373
57MAPK150.83249587
58MAPK70.82537164
59MAPK120.81328328
60IGF1R0.79651600
61WNK40.77871459
62TEC0.77727777
63CSNK1G10.76524647
64TBK10.74997030
65BMX0.74981265
66PIK3CA0.74231294
67STK30.73750418
68RPS6KA40.71953502
69EPHA20.69916996
70BCR0.69383127
71LIMK10.68765326
72TRIM280.68602413
73MST40.68466092
74JAK30.68131071
75PAK30.67579616
76GSK3A0.65912069
77IRAK40.65881650
78BRSK20.64956271
79CSNK1G30.64230747
80IKBKE0.63968600
81TLK10.62068248
82ADRBK10.60941983
83PRKG20.59861092
84CSNK1G20.58671311
85PIM10.57900037
86ZAP700.55839909
87INSRR0.55705876
88ROCK10.54555991
89MARK10.53594887
90PRKCG0.53587673
91ERBB40.51483416
92STK38L0.51121305
93TNIK0.50730759
94VRK10.49989787
95FES0.47602356
96NTRK30.47444815
97MAP3K40.47371012
98GRK50.47292312
99MAP2K20.47210934
100DYRK1B0.46206466
101SIK30.45638428
102WNK30.45604822
103TXK0.45448719
104CAMK1D0.45188636
105EIF2AK20.45014056
106NTRK10.44934192
107MAP3K90.44564280
108CAMKK20.44490482
109CDC42BPA0.43946536
110INSR0.43939819
111SCYL20.43905645
112CAMK2A0.42229839
113NLK0.41602068
114CSK0.41527209
115LATS20.41206977
116DAPK20.40826416
117ITK0.39609736
118PRPF4B0.39571903
119MKNK20.38468122
120MAP3K130.37553739
121ABL10.37371773
122EGFR0.36790723
123PRKAA20.36496831
124ROCK20.35776775
125JAK10.35447488
126MAPKAPK50.35397885
127SGK20.35265210
128OXSR10.34958153
129ABL20.33875199
130FGFR20.33394610
131MAP2K10.33189071
132CAMK10.33098895
133DYRK20.32738272
134CDK90.32589509
135PRKD10.32403181
136FGFR10.31218418
137SRC0.30294176
138NTRK20.30190946
139MATK0.30174306
140MAPKAPK30.30107406
141CSNK1A1L0.29631405
142ARAF0.29039104
143PRKCE0.28512648
144SRPK10.27550571
145KSR10.27128751
146MOS0.26066654
147STK110.25732622
148MINK10.25564673
149DAPK10.24787059
150ILK0.23153569
151CAMK2B0.22764587
152PLK30.21519001
153WEE10.20814034
154CDK30.20667804
155DAPK30.20549447

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.30423445
2Focal adhesion_Homo sapiens_hsa045102.70503195
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.43014502
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.36376126
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.35618974
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.29441000
7Adherens junction_Homo sapiens_hsa045202.26645644
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.23672510
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18640858
10Dilated cardiomyopathy_Homo sapiens_hsa054142.13538727
11Phototransduction_Homo sapiens_hsa047442.10695803
12Complement and coagulation cascades_Homo sapiens_hsa046102.03745533
13Malaria_Homo sapiens_hsa051441.95415769
14Proteoglycans in cancer_Homo sapiens_hsa052051.85411443
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.85196228
16Small cell lung cancer_Homo sapiens_hsa052221.75255761
17Morphine addiction_Homo sapiens_hsa050321.74805993
18Thyroid cancer_Homo sapiens_hsa052161.73738008
19* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.70849113
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65409985
21Nicotine addiction_Homo sapiens_hsa050331.64530426
22Prostate cancer_Homo sapiens_hsa052151.63353541
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60776319
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60310544
25Oxidative phosphorylation_Homo sapiens_hsa001901.59441192
26Nitrogen metabolism_Homo sapiens_hsa009101.57465946
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54171410
28TGF-beta signaling pathway_Homo sapiens_hsa043501.51990965
29MicroRNAs in cancer_Homo sapiens_hsa052061.51162604
30GABAergic synapse_Homo sapiens_hsa047271.49110101
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48619397
32Viral myocarditis_Homo sapiens_hsa054161.47274310
33Glutamatergic synapse_Homo sapiens_hsa047241.46632836
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46577044
35Taste transduction_Homo sapiens_hsa047421.45379717
36Selenocompound metabolism_Homo sapiens_hsa004501.42082709
37* Rap1 signaling pathway_Homo sapiens_hsa040151.42044787
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.41749259
39Parkinsons disease_Homo sapiens_hsa050121.41722893
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39388681
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37746340
42Circadian entrainment_Homo sapiens_hsa047131.35630303
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.34801259
44Ether lipid metabolism_Homo sapiens_hsa005651.34728571
45Melanoma_Homo sapiens_hsa052181.31507059
46Protein digestion and absorption_Homo sapiens_hsa049741.31212603
47Serotonergic synapse_Homo sapiens_hsa047261.26269809
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24278356
49TNF signaling pathway_Homo sapiens_hsa046681.24040700
50Butanoate metabolism_Homo sapiens_hsa006501.22917826
51Amoebiasis_Homo sapiens_hsa051461.21073070
52Pathways in cancer_Homo sapiens_hsa052001.20433076
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.17803403
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17072445
55Linoleic acid metabolism_Homo sapiens_hsa005911.16853772
56Chronic myeloid leukemia_Homo sapiens_hsa052201.16756139
57Platelet activation_Homo sapiens_hsa046111.16654743
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.16637290
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16460065
60Basal transcription factors_Homo sapiens_hsa030221.15062852
61Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13794948
62Hippo signaling pathway_Homo sapiens_hsa043901.12756719
63Sphingolipid metabolism_Homo sapiens_hsa006001.11616335
64Regulation of autophagy_Homo sapiens_hsa041401.08812665
65Collecting duct acid secretion_Homo sapiens_hsa049661.08122659
66Tight junction_Homo sapiens_hsa045301.07662627
67Olfactory transduction_Homo sapiens_hsa047401.07040501
68Dorso-ventral axis formation_Homo sapiens_hsa043201.06997602
69Phagosome_Homo sapiens_hsa041451.06618151
70Alzheimers disease_Homo sapiens_hsa050101.06308803
71* Ras signaling pathway_Homo sapiens_hsa040141.05232361
72Bladder cancer_Homo sapiens_hsa052191.04798365
73Osteoclast differentiation_Homo sapiens_hsa043801.04069165
74Hematopoietic cell lineage_Homo sapiens_hsa046401.01815446
75ABC transporters_Homo sapiens_hsa020100.99179299
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98540404
77Proteasome_Homo sapiens_hsa030500.98410144
78Sulfur metabolism_Homo sapiens_hsa009200.98037192
79Toxoplasmosis_Homo sapiens_hsa051450.97785510
80Apoptosis_Homo sapiens_hsa042100.97727793
81p53 signaling pathway_Homo sapiens_hsa041150.97193474
82Protein export_Homo sapiens_hsa030600.96339550
83Melanogenesis_Homo sapiens_hsa049160.95227516
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94152495
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94115554
86Renin secretion_Homo sapiens_hsa049240.94081032
87Notch signaling pathway_Homo sapiens_hsa043300.93992015
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93360006
89Long-term depression_Homo sapiens_hsa047300.91947177
90Pertussis_Homo sapiens_hsa051330.90809423
91Basal cell carcinoma_Homo sapiens_hsa052170.90711872
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90658286
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89545846
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89000404
95Rheumatoid arthritis_Homo sapiens_hsa053230.87868065
96Lysosome_Homo sapiens_hsa041420.85246885
97Hedgehog signaling pathway_Homo sapiens_hsa043400.83368261
98HTLV-I infection_Homo sapiens_hsa051660.83248920
99Thyroid hormone synthesis_Homo sapiens_hsa049180.82793615
100Leishmaniasis_Homo sapiens_hsa051400.80310809
101Galactose metabolism_Homo sapiens_hsa000520.77891710
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77344996
103Hepatitis B_Homo sapiens_hsa051610.76806372
104Endometrial cancer_Homo sapiens_hsa052130.76535414
105Lysine degradation_Homo sapiens_hsa003100.76357676
106Dopaminergic synapse_Homo sapiens_hsa047280.75909576
107FoxO signaling pathway_Homo sapiens_hsa040680.75773451
108* HIF-1 signaling pathway_Homo sapiens_hsa040660.75291993
109Caffeine metabolism_Homo sapiens_hsa002320.74655683
110Chemical carcinogenesis_Homo sapiens_hsa052040.74633694
111Renal cell carcinoma_Homo sapiens_hsa052110.74017398
112Tryptophan metabolism_Homo sapiens_hsa003800.73952310
113Axon guidance_Homo sapiens_hsa043600.72738273
114cAMP signaling pathway_Homo sapiens_hsa040240.71143555
115Wnt signaling pathway_Homo sapiens_hsa043100.70979165
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70853291
117Propanoate metabolism_Homo sapiens_hsa006400.70727252
118Cardiac muscle contraction_Homo sapiens_hsa042600.70676218
119Arachidonic acid metabolism_Homo sapiens_hsa005900.69740361
120Calcium signaling pathway_Homo sapiens_hsa040200.68927946
121Hepatitis C_Homo sapiens_hsa051600.67844781
122Glioma_Homo sapiens_hsa052140.65338435
123Huntingtons disease_Homo sapiens_hsa050160.65195203
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64966398
125Insulin secretion_Homo sapiens_hsa049110.64383536
126African trypanosomiasis_Homo sapiens_hsa051430.64088831
127Legionellosis_Homo sapiens_hsa051340.64056030
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63320677
129Circadian rhythm_Homo sapiens_hsa047100.63138044
130Ovarian steroidogenesis_Homo sapiens_hsa049130.61923872
131Shigellosis_Homo sapiens_hsa051310.60700190
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60091943
133Salmonella infection_Homo sapiens_hsa051320.58808707
134Salivary secretion_Homo sapiens_hsa049700.58341932
135Peroxisome_Homo sapiens_hsa041460.57778303
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57747383
137Cocaine addiction_Homo sapiens_hsa050300.56280637
138Pancreatic cancer_Homo sapiens_hsa052120.55727659
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54893489
140Gap junction_Homo sapiens_hsa045400.54654454
141Glycerolipid metabolism_Homo sapiens_hsa005610.52701057
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52537539
143Starch and sucrose metabolism_Homo sapiens_hsa005000.51564997
144Measles_Homo sapiens_hsa051620.51097905
145Viral carcinogenesis_Homo sapiens_hsa052030.50540224
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.49274613
147Arginine and proline metabolism_Homo sapiens_hsa003300.48437436
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47143637
149Influenza A_Homo sapiens_hsa051640.46232482
150Cholinergic synapse_Homo sapiens_hsa047250.46153549
151Mineral absorption_Homo sapiens_hsa049780.46033879
152Vibrio cholerae infection_Homo sapiens_hsa051100.45997512
153NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45612604
154Oxytocin signaling pathway_Homo sapiens_hsa049210.45546366
155Vitamin digestion and absorption_Homo sapiens_hsa049770.45182696
156Tuberculosis_Homo sapiens_hsa051520.44932748
157Gastric acid secretion_Homo sapiens_hsa049710.44410132
158Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44075475
159Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42958451
160Insulin resistance_Homo sapiens_hsa049310.42866514
161Jak-STAT signaling pathway_Homo sapiens_hsa046300.41674477
162cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41471288

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