ANGPTL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)6.35171750
2protein heterotrimerization (GO:0070208)6.21578745
3glomerular visceral epithelial cell development (GO:0072015)6.09344809
4collagen fibril organization (GO:0030199)6.03989324
5glomerular epithelial cell development (GO:0072310)5.28723767
6chondrocyte proliferation (GO:0035988)4.82526722
7regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.76655339
8sequestering of extracellular ligand from receptor (GO:0035581)4.50436813
9cell adhesion mediated by integrin (GO:0033627)4.39417443
10endodermal cell differentiation (GO:0035987)4.37194559
11wound healing, spreading of epidermal cells (GO:0035313)4.31833221
12collagen metabolic process (GO:0032963)4.18808374
13regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.17837773
14vascular endothelial growth factor signaling pathway (GO:0038084)4.17741442
15collagen catabolic process (GO:0030574)4.05731344
16multicellular organismal macromolecule metabolic process (GO:0044259)4.03592177
17plasma membrane repair (GO:0001778)4.02749615
18apoptotic cell clearance (GO:0043277)3.99662385
19dermatan sulfate biosynthetic process (GO:0030208)3.97696771
20basement membrane organization (GO:0071711)3.90248514
21retina vasculature morphogenesis in camera-type eye (GO:0061299)3.87561791
22multicellular organismal metabolic process (GO:0044236)3.83628734
23multicellular organismal catabolic process (GO:0044243)3.81757381
24skin morphogenesis (GO:0043589)3.81014659
25neuron projection extension involved in neuron projection guidance (GO:1902284)3.80857368
26axon extension involved in axon guidance (GO:0048846)3.80857368
27bone trabecula formation (GO:0060346)3.80240569
28regulation of tight junction assembly (GO:2000810)3.63432451
29extracellular matrix disassembly (GO:0022617)3.61989104
30dermatan sulfate metabolic process (GO:0030205)3.61729300
31peptidyl-proline hydroxylation (GO:0019511)3.57839041
32negative regulation of fatty acid transport (GO:2000192)3.56561857
33virion attachment to host cell (GO:0019062)3.55666282
34adhesion of symbiont to host cell (GO:0044650)3.55666282
35keratan sulfate catabolic process (GO:0042340)3.54517910
36extracellular fibril organization (GO:0043206)3.53320185
37wound healing, spreading of cells (GO:0044319)3.51984876
38fibril organization (GO:0097435)3.46570185
39positive regulation of endothelial cell apoptotic process (GO:2000353)3.46500336
40metanephric mesenchyme development (GO:0072075)3.43413498
41epithelial cell-cell adhesion (GO:0090136)3.41891240
42endothelial cell morphogenesis (GO:0001886)3.39529730
43protein hydroxylation (GO:0018126)3.37880875
44blood vessel maturation (GO:0001955)3.36383901
45kidney mesenchyme development (GO:0072074)3.35974202
46regulation of integrin-mediated signaling pathway (GO:2001044)3.33595134
47positive regulation of blood vessel endothelial cell migration (GO:0043536)3.26256400
48positive regulation of p38MAPK cascade (GO:1900745)3.23256274
49cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.22879878
50barbed-end actin filament capping (GO:0051016)3.19888506
51stress fiber assembly (GO:0043149)3.17093543
52cell migration involved in sprouting angiogenesis (GO:0002042)3.16026064
53cellular response to vitamin (GO:0071295)3.14949556
54protein targeting to plasma membrane (GO:0072661)3.14755072
55adhesion of symbiont to host (GO:0044406)3.14681384
56positive regulation of osteoblast proliferation (GO:0033690)3.10401698
57regulation of extracellular matrix disassembly (GO:0010715)3.09222433
58cellular response to interferon-alpha (GO:0035457)3.08142871
59cell migration involved in heart development (GO:0060973)3.07191626
60cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.06614804
61chondroitin sulfate catabolic process (GO:0030207)3.04940313
62actin-myosin filament sliding (GO:0033275)3.04842217
63muscle filament sliding (GO:0030049)3.04842217
64cardiac myofibril assembly (GO:0055003)3.04728989
65extracellular matrix organization (GO:0030198)3.02669339
66extracellular structure organization (GO:0043062)3.01371518
67sarcomere organization (GO:0045214)3.00397805
68renal filtration (GO:0097205)3.00246010
69mesenchymal-epithelial cell signaling (GO:0060638)2.99196439
70extracellular matrix assembly (GO:0085029)2.98314838
71lymphangiogenesis (GO:0001946)2.96262164
72peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.95628137
73positive regulation of epithelial to mesenchymal transition (GO:0010718)2.94279871
74negative regulation of chondrocyte differentiation (GO:0032331)2.93394703
75substrate adhesion-dependent cell spreading (GO:0034446)2.92239481
76actin-mediated cell contraction (GO:0070252)2.89278542
77triglyceride catabolic process (GO:0019433)2.88641417
78tooth mineralization (GO:0034505)2.85918785
79cell proliferation involved in metanephros development (GO:0072203)2.85511546
80glomerulus development (GO:0032835)2.85267791
81glomerular filtration (GO:0003094)2.84010784
82regulation of p38MAPK cascade (GO:1900744)2.80173739
83protein retention in ER lumen (GO:0006621)2.79030528
84cell-substrate junction assembly (GO:0007044)2.79029290
85membrane raft organization (GO:0031579)2.77674945
86maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.77561713
87low-density lipoprotein particle clearance (GO:0034383)2.76753751
88regulation of sequestering of triglyceride (GO:0010889)2.75205299
89positive regulation of natural killer cell differentiation (GO:0032825)2.74278045
90trabecula formation (GO:0060343)2.74140510
91positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.73583425
92muscle cell migration (GO:0014812)2.72506661
93protein localization to cell surface (GO:0034394)2.71175332
94negative regulation of smooth muscle cell migration (GO:0014912)2.71047110
95fibroblast migration (GO:0010761)2.68573363
96type B pancreatic cell proliferation (GO:0044342)2.66914630
97craniofacial suture morphogenesis (GO:0097094)2.66766726
98positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.66178785
99cGMP-mediated signaling (GO:0019934)2.66092084
100negative regulation of BMP signaling pathway (GO:0030514)2.65621894
101chondroitin sulfate biosynthetic process (GO:0030206)2.64372324
102cardiac muscle cell proliferation (GO:0060038)2.62765079
103wound healing (GO:0042060)2.62597744
104vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.62094957
105positive regulation of cartilage development (GO:0061036)2.61185885
106positive regulation of fatty acid oxidation (GO:0046321)2.60367166
107Golgi transport vesicle coating (GO:0048200)2.59878805
108COPI coating of Golgi vesicle (GO:0048205)2.59878805
109hemidesmosome assembly (GO:0031581)2.58560914
110neutral lipid catabolic process (GO:0046461)2.58444744
111acylglycerol catabolic process (GO:0046464)2.58444744
112venous blood vessel morphogenesis (GO:0048845)2.58428867
113positive regulation of extracellular matrix organization (GO:1903055)2.57572008
114endothelial cell proliferation (GO:0001935)2.56774648
115negative regulation of cartilage development (GO:0061037)2.56405282
116response to fluid shear stress (GO:0034405)2.56120669
117blood vessel endothelial cell migration (GO:0043534)2.53415369
118chondrocyte development (GO:0002063)2.49217904
119glycosaminoglycan catabolic process (GO:0006027)2.46765559
120endocrine hormone secretion (GO:0060986)2.46627545
121regulation of smooth muscle cell migration (GO:0014910)2.40244962
122myofibril assembly (GO:0030239)2.39714925
123planar cell polarity pathway involved in neural tube closure (GO:0090179)2.37710549
124positive regulation of receptor recycling (GO:0001921)2.36560515
125atrioventricular valve morphogenesis (GO:0003181)2.35732298
126endocardial cushion development (GO:0003197)2.35402619
127cellular response to epinephrine stimulus (GO:0071872)2.34535732
128smooth muscle tissue development (GO:0048745)2.33852645
129cell proliferation involved in kidney development (GO:0072111)2.33112724
130phagocytosis, recognition (GO:0006910)2.32753928
131regulation of glucose import in response to insulin stimulus (GO:2001273)2.32046267
132regulation of axon extension involved in axon guidance (GO:0048841)2.31819543
133positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.31338053
134adherens junction assembly (GO:0034333)2.27204500
135regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.24905265
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.24638436
137paraxial mesoderm development (GO:0048339)2.24131112
138negative regulation of protein localization to cell surface (GO:2000009)2.23549114
139regulation of osteoblast proliferation (GO:0033688)2.22526436
140negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.21741434
141response to epinephrine (GO:0071871)2.21598980
142aminoglycan catabolic process (GO:0006026)2.20880574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.29611518
2RARG_19884340_ChIP-ChIP_MEFs_Mouse5.43425216
3TP63_17297297_ChIP-ChIP_HaCaT_Human5.27491146
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.75929790
5* CLOCK_20551151_ChIP-Seq_293T_Human3.74851289
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.45812900
7* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.17859514
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.17514417
9* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.01168585
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00507113
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.74773860
12CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.65915600
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.54875028
14CJUN_26792858_Chip-Seq_BT549_Human2.53013916
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.48498260
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.41554619
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.39209164
18* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.34129536
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.17767437
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.13618069
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.08970218
22BRD4_25478319_ChIP-Seq_HGPS_Human2.08920152
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02598760
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02598760
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99740714
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99616936
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.98488425
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93706338
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93307754
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85820494
31* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85152209
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83900599
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81455682
34* TBX20_22080862_ChIP-Seq_HEART_Mouse1.80828751
35* TBX20_22328084_ChIP-Seq_HEART_Mouse1.80828751
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.80503120
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77429675
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.74846714
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.74846714
40MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.70885414
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70436330
42SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69956148
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69956148
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66310761
45* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.63851567
46* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63745557
47SMC1_22415368_ChIP-Seq_MEFs_Mouse1.58156614
48NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.54427392
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53122841
50JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47599117
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.46908382
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46894269
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.46755795
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46455074
55ATF3_27146783_Chip-Seq_COLON_Human1.46317847
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46103644
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.44621523
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40417234
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.39102634
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38122891
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37151599
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36973651
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.35120204
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34010191
65SOX2_20726797_ChIP-Seq_SW620_Human1.32408104
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32110017
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30651075
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30569195
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30466885
70RACK7_27058665_Chip-Seq_MCF-7_Human1.29661325
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29041937
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.27422217
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26109068
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.25727851
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25029685
76PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.24837982
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24584380
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24351402
79TP53_22127205_ChIP-Seq_IMR90_Human1.23592734
80* TP53_20018659_ChIP-ChIP_R1E_Mouse1.22900623
81* TP53_23651856_ChIP-Seq_MEFs_Mouse1.21721223
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20114811
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.19014150
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18335399
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18122323
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18016715
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16710458
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16570883
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15811383
90RXR_22158963_ChIP-Seq_LIVER_Mouse1.13257283
91TP53_16413492_ChIP-PET_HCT116_Human1.10596639
92TP53_18474530_ChIP-ChIP_U2OS_Human1.09876360
93SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09505115
94DROSHA_22980978_ChIP-Seq_HELA_Human1.09009781
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08554429
96LXR_22292898_ChIP-Seq_THP-1_Human1.07418906
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07332448
98* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.07201387
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.06171076
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04589625
101EZH2_22144423_ChIP-Seq_EOC_Human1.03943842
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.03730588
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02529576
104LXR_22158963_ChIP-Seq_LIVER_Mouse1.01504431
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01274360
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01128275
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01086300
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00773185
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99193160
110NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98738559
111ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98231592
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98207798
113KDM2B_26808549_Chip-Seq_DND41_Human0.96290868
114* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96286220
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96110858
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96006917
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94079638
118* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93430651
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92938057
120GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92787214
121RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92619692
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92289668
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92051340
124TET1_21490601_ChIP-Seq_MESCs_Mouse0.90730859
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90397531
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90339493
127KDM2B_26808549_Chip-Seq_K562_Human0.90075862
128NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88926589
129ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88254877
130ZNF263_19887448_ChIP-Seq_K562_Human0.86826995
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86197930
132ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85884024
133RING1B_27294783_Chip-Seq_NPCs_Mouse0.85437288
134SA1_22415368_ChIP-Seq_MEFs_Mouse0.85376656
135Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84099095
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.84024962
137EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83806910
138STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.83334762
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82150963
140* NFI_21473784_ChIP-Seq_ESCs_Mouse0.82010156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.73772651
2MP0005503_abnormal_tendon_morphology5.08574217
3MP0005275_abnormal_skin_tensile4.94205909
4MP0003705_abnormal_hypodermis_morpholog4.59555290
5MP0003279_aneurysm3.76726167
6MP0001958_emphysema3.18170007
7MP0004272_abnormal_basement_membrane3.10243973
8MP0009384_cardiac_valve_regurgitation2.46761440
9MP0005623_abnormal_meninges_morphology2.30497411
10MP0000751_myopathy2.29204065
11MP0004084_abnormal_cardiac_muscle2.08474855
12MP0010030_abnormal_orbit_morphology2.02046223
13MP0003566_abnormal_cell_adhesion1.98759321
14MP0010368_abnormal_lymphatic_system1.91746171
15MP0005508_abnormal_skeleton_morphology1.89586564
16MP0002060_abnormal_skin_morphology1.88359371
17MP0005023_abnormal_wound_healing1.83671441
18MP0000750_abnormal_muscle_regeneration1.81581941
19MP0002837_dystrophic_cardiac_calcinosis1.78595129
20MP0002108_abnormal_muscle_morphology1.75806479
21MP0003091_abnormal_cell_migration1.64839218
22MP0006054_spinal_hemorrhage1.61705701
23MP0005257_abnormal_intraocular_pressure1.56720901
24MP0000749_muscle_degeneration1.55166796
25MP0002295_abnormal_pulmonary_circulatio1.52341630
26MP0000733_abnormal_muscle_development1.50345215
27MP0000013_abnormal_adipose_tissue1.46390149
28MP0002971_abnormal_brown_adipose1.45463882
29MP0001879_abnormal_lymphatic_vessel1.37626753
30MP0009780_abnormal_chondrocyte_physiolo1.37612223
31MP0001243_abnormal_dermal_layer1.37336493
32MP0002933_joint_inflammation1.36628308
33MP0009250_abnormal_appendicular_skeleto1.36432960
34MP0000767_abnormal_smooth_muscle1.35163578
35MP0010352_gastrointestinal_tract_polyps1.33292796
36MP0001299_abnormal_eye_distance/1.31573324
37MP0003950_abnormal_plasma_membrane1.30210299
38MP0004087_abnormal_muscle_fiber1.29992817
39MP0002896_abnormal_bone_mineralization1.25945218
40MP0002877_abnormal_melanocyte_morpholog1.24340221
41MP0004036_abnormal_muscle_relaxation1.23576043
42MP0008775_abnormal_heart_ventricle1.21638653
43MP0005330_cardiomyopathy1.20038557
44MP0001542_abnormal_bone_strength1.18021389
45MP0004858_abnormal_nervous_system1.17978502
46MP0000759_abnormal_skeletal_muscle1.16855314
47MP0005390_skeleton_phenotype1.16843493
48MP0003385_abnormal_body_wall1.13698379
49MP0000163_abnormal_cartilage_morphology1.13240611
50MP0005670_abnormal_white_adipose1.12517977
51MP0000003_abnormal_adipose_tissue1.11333134
52MP0004233_abnormal_muscle_weight1.10496876
53MP0005171_absent_coat_pigmentation1.07801328
54MP0004185_abnormal_adipocyte_glucose1.06861338
55MP0002115_abnormal_skeleton_extremities1.04012785
56MP0000343_altered_response_to1.01152162
57MP0005369_muscle_phenotype1.01032655
58MP0000747_muscle_weakness0.97893982
59MP0002972_abnormal_cardiac_muscle0.97832645
60MP0005620_abnormal_muscle_contractility0.97356134
61MP0005375_adipose_tissue_phenotype0.97002317
62MP0002282_abnormal_trachea_morphology0.96973682
63MP0001544_abnormal_cardiovascular_syste0.96699875
64MP0005385_cardiovascular_system_phenoty0.96699875
65MP0005666_abnormal_adipose_tissue0.96574367
66MP0006138_congestive_heart_failure0.96570991
67MP0004130_abnormal_muscle_cell0.96243278
68MP0002128_abnormal_blood_circulation0.96103032
69MP0009115_abnormal_fat_cell0.95909354
70MP0003942_abnormal_urinary_system0.95556835
71MP0010630_abnormal_cardiac_muscle0.94378622
72MP0002269_muscular_atrophy0.91455583
73MP0004134_abnormal_chest_morphology0.91228505
74MP0002998_abnormal_bone_remodeling0.89714450
75MP0002168_other_aberrant_phenotype0.89049515
76MP0003828_pulmonary_edema0.88557078
77MP0003959_abnormal_lean_body0.88524164
78MP0000534_abnormal_ureter_morphology0.88040428
79MP0003941_abnormal_skin_development0.87303848
80MP0002113_abnormal_skeleton_development0.85948727
81MP0001533_abnormal_skeleton_physiology0.85712791
82MP0002106_abnormal_muscle_physiology0.85229460
83MP0001614_abnormal_blood_vessel0.84677525
84MP0005409_darkened_coat_color0.83981550
85MP0003115_abnormal_respiratory_system0.82999676
86MP0005595_abnormal_vascular_smooth0.82924723
87MP0003045_fibrosis0.81141962
88MP0000428_abnormal_craniofacial_morphol0.80809031
89MP0005165_increased_susceptibility_to0.79483407
90MP0002089_abnormal_postnatal_growth/wei0.79401586
91MP0002932_abnormal_joint_morphology0.79075001
92MP0003283_abnormal_digestive_organ0.76824728
93MP0005076_abnormal_cell_differentiation0.76604873
94MP0002254_reproductive_system_inflammat0.76415074
95MP0003690_abnormal_glial_cell0.76351916
96MP0003795_abnormal_bone_structure0.72941785
97MP0009053_abnormal_anal_canal0.72144504
98MP0005197_abnormal_uvea_morphology0.71997898
99MP0003300_gastrointestinal_ulcer0.71965765
100MP0000462_abnormal_digestive_system0.71081605
101MP0000249_abnormal_blood_vessel0.70586944
102MP0001849_ear_inflammation0.69328755
103MP0005058_abnormal_lysosome_morphology0.69117470
104MP0001175_abnormal_lung_morphology0.67049857
105MP0000049_abnormal_middle_ear0.66825178
106MP0004215_abnormal_myocardial_fiber0.66614557
107MP0000762_abnormal_tongue_morphology0.66071405
108MP0002925_abnormal_cardiovascular_devel0.65517943
109MP0001661_extended_life_span0.64865077
110MP0009840_abnormal_foam_cell0.64483390
111MP0003329_amyloid_beta_deposits0.64028454
112MP0004883_abnormal_blood_vessel0.63589852
113MP0000266_abnormal_heart_morphology0.62755129
114MP0003448_altered_tumor_morphology0.62555034
115MP0005164_abnormal_response_to0.62310149
116MP0000604_amyloidosis0.61993851
117MP0001915_intracranial_hemorrhage0.61674821
118MP0002249_abnormal_larynx_morphology0.61474533
119MP0003646_muscle_fatigue0.60919279
120MP0005388_respiratory_system_phenotype0.60747473
121MP0002133_abnormal_respiratory_system0.60747473

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.86013444
2Premature rupture of membranes (HP:0001788)7.13634817
3Ankle contracture (HP:0006466)5.01285286
4Aortic aneurysm (HP:0004942)4.49091754
5Aortic dissection (HP:0002647)4.48792851
6Broad metatarsal (HP:0001783)4.36055223
7Increased connective tissue (HP:0009025)4.34699238
8Soft skin (HP:0000977)4.16175415
9Type 1 muscle fiber predominance (HP:0003803)4.15037765
10Shallow orbits (HP:0000586)4.02024913
11Cerebral aneurysm (HP:0004944)3.95410800
12Wrist flexion contracture (HP:0001239)3.78464947
13Vertebral compression fractures (HP:0002953)3.73781526
14Cervical subluxation (HP:0003308)3.72370142
15Spinal rigidity (HP:0003306)3.70151568
16Atrophic scars (HP:0001075)3.64347311
17Dilatation of the ascending aorta (HP:0005111)3.60521877
18Peritonitis (HP:0002586)3.50958569
19Bladder diverticulum (HP:0000015)3.50287940
20Fragile skin (HP:0001030)3.34688139
21Wormian bones (HP:0002645)3.19275331
22Follicular hyperkeratosis (HP:0007502)3.16606967
23Round ear (HP:0100830)3.09051726
24Blue sclerae (HP:0000592)3.07598483
25Abnormality of dentin (HP:0010299)2.98473554
26Vascular tortuosity (HP:0004948)2.92597987
27Genu recurvatum (HP:0002816)2.87615938
28Biconcave vertebral bodies (HP:0004586)2.79978139
29Mitral valve prolapse (HP:0001634)2.79832542
30Increased variability in muscle fiber diameter (HP:0003557)2.79353237
31Overgrowth (HP:0001548)2.77745439
32Mild short stature (HP:0003502)2.77035730
33Mildly elevated creatine phosphokinase (HP:0008180)2.76672586
34Muscle fiber splitting (HP:0003555)2.75908326
35Neonatal short-limb short stature (HP:0008921)2.70858614
36Arterial tortuosity (HP:0005116)2.70607072
37Mesangial abnormality (HP:0001966)2.65347699
38Aneurysm (HP:0002617)2.62249449
39Slender build (HP:0001533)2.59472445
40Abnormality of skeletal muscle fiber size (HP:0012084)2.54856421
41Elbow flexion contracture (HP:0002987)2.49567218
42Abnormality of the acetabulum (HP:0003170)2.48725689
43Difficulty climbing stairs (HP:0003551)2.47407072
44Hyperextensible skin (HP:0000974)2.40654172
45Right ventricular cardiomyopathy (HP:0011663)2.36756936
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.36326597
47Osteolytic defects of the hand bones (HP:0009699)2.36326597
48Thin bony cortex (HP:0002753)2.31788767
49Aortic regurgitation (HP:0001659)2.29865298
50Scapular winging (HP:0003691)2.28399561
51Joint stiffness (HP:0001387)2.26938274
52Bowel diverticulosis (HP:0005222)2.26282835
53Abnormal delivery (HP:0001787)2.25554381
54Camptodactyly of toe (HP:0001836)2.23977467
55Metaphyseal dysplasia (HP:0100255)2.23647342
56Coronal craniosynostosis (HP:0004440)2.21328496
57Coxa vara (HP:0002812)2.20355009
58Absent frontal sinuses (HP:0002688)2.19103112
59Papilledema (HP:0001085)2.18256861
60Ulnar deviation of the wrist (HP:0003049)2.16134744
61Spondylolisthesis (HP:0003302)2.15342486
62Hyporeflexia of lower limbs (HP:0002600)2.15034535
63Short nail (HP:0001799)2.14108382
64Knee flexion contracture (HP:0006380)2.11339060
65Generalized amyotrophy (HP:0003700)2.11202868
66Hip contracture (HP:0003273)2.10532232
67Joint laxity (HP:0001388)2.09365042
68Hypoventilation (HP:0002791)2.08687904
69Mitral stenosis (HP:0001718)2.08543045
70Abnormality of the ischium (HP:0003174)2.07698985
71Abnormality of complement system (HP:0005339)2.07463843
72Pulmonary artery stenosis (HP:0004415)2.06271363
73Lipoatrophy (HP:0100578)2.05924332
74Aortic valve stenosis (HP:0001650)2.05503545
75Ectopia lentis (HP:0001083)2.05287447
76Distal lower limb amyotrophy (HP:0008944)2.04535152
77Venous abnormality (HP:0002624)2.03192530
78Mesomelia (HP:0003027)2.01987751
79Hypoplasia of the iris (HP:0007676)2.01502177
80Turricephaly (HP:0000262)2.01006559
81Systemic lupus erythematosus (HP:0002725)2.00934616
82Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.98367613
83Delayed cranial suture closure (HP:0000270)1.97441361
84Nemaline bodies (HP:0003798)1.97386483
85Abnormality of the calf musculature (HP:0001430)1.97292945
86Tibial bowing (HP:0002982)1.97193425
87Breech presentation (HP:0001623)1.96578722
88Distal lower limb muscle weakness (HP:0009053)1.96204744
89Mitral regurgitation (HP:0001653)1.95494405
90Muscle fiber inclusion bodies (HP:0100299)1.95101885
91Complement deficiency (HP:0004431)1.93771626
92Delayed closure of the anterior fontanelle (HP:0001476)1.93356802
93Bell-shaped thorax (HP:0001591)1.93152429
94Wide anterior fontanel (HP:0000260)1.93061637
95Exercise-induced muscle cramps (HP:0003710)1.93034905
96Limited hip movement (HP:0008800)1.91056284
97Osteoarthritis (HP:0002758)1.90229741
98Increased density of long bones (HP:0006392)1.88726769
99Hypoplastic ischia (HP:0003175)1.87676373
100Platyspondyly (HP:0000926)1.85973810
101Femoral bowing (HP:0002980)1.85710171
102Nonimmune hydrops fetalis (HP:0001790)1.83421995
103Ovoid vertebral bodies (HP:0003300)1.83346415
104Distal upper limb amyotrophy (HP:0007149)1.83220856
105Upper limb amyotrophy (HP:0009129)1.83220856
106Beaking of vertebral bodies (HP:0004568)1.83119132
107Infantile muscular hypotonia (HP:0008947)1.82989297
108Limb-girdle muscle weakness (HP:0003325)1.82655360
109Metaphyseal cupping (HP:0003021)1.82326969
110Oligomenorrhea (HP:0000876)1.80051332
111Obstructive sleep apnea (HP:0002870)1.79939211
112Back pain (HP:0003418)1.79498191
113Flared iliac wings (HP:0002869)1.78734114
114EMG: myopathic abnormalities (HP:0003458)1.77157544
115Difficulty running (HP:0009046)1.76860979
116Venous insufficiency (HP:0005293)1.76356331
117Striae distensae (HP:0001065)1.76306936
118Focal segmental glomerulosclerosis (HP:0000097)1.76167717
119Osteopenia (HP:0000938)1.75962307
120Asymmetric septal hypertrophy (HP:0001670)1.75091504
121Lymphangioma (HP:0100764)1.74659515
122Abnormality of the peritoneum (HP:0002585)1.73267338
123Exercise-induced myalgia (HP:0003738)1.72699293
124Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72520420
125Ulnar bowing (HP:0003031)1.72245810
126Joint contractures involving the joints of the feet (HP:0100492)1.72221053
127Flexion contracture of toe (HP:0005830)1.72221053
128Deviation of the hallux (HP:0010051)1.71709799
129Broad ribs (HP:0000885)1.70025254
130Limb-girdle muscle atrophy (HP:0003797)1.69032522
131Cupped ribs (HP:0000887)1.68884089
132Achilles tendon contracture (HP:0001771)1.68628323
133Persistence of primary teeth (HP:0006335)1.68455702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.83110474
2TRIB34.74979864
3DDR23.48305686
4PDGFRA3.09582526
5PKN22.81558710
6LATS22.79958796
7ERN12.44407889
8LATS12.35380834
9EPHB22.17359313
10SIK12.15400278
11NTRK12.12064076
12TGFBR22.10626061
13MYLK1.98130245
14TRPM71.95184177
15PAK21.71365918
16MOS1.61418096
17DMPK1.60565769
18RIPK11.59389137
19FER1.50337957
20MAP3K61.44577625
21NEK91.43018255
22PAK41.41754118
23CAMK1D1.40915767
24MAP3K31.37515996
25TESK11.36176125
26TGFBR11.33401370
27LRRK21.32922489
28PIK3CA1.32622486
29MAPK71.28400727
30GRK51.23777241
31LIMK11.23620776
32BMX1.23337103
33ROCK11.22315887
34RPS6KA41.21931642
35PAK31.20636650
36STK38L1.18329919
37NME21.18222321
38MARK11.17922424
39EPHA31.17102364
40MAPKAPK31.16649032
41PTK2B1.16037737
42ILK1.15997128
43PTK61.15522553
44PTK21.15242954
45EEF2K1.14990341
46MAP2K31.12627441
47EPHB11.09175904
48PIK3CG1.07523289
49MAP3K71.06402442
50STK31.03064465
51MAP2K11.01668642
52PDGFRB1.01611069
53FGFR11.00702003
54ADRBK10.98430285
55ERBB30.98235137
56KDR0.98003819
57MET0.92740095
58FGFR40.92623524
59STK380.91886481
60PRKAA20.91008787
61ICK0.90933472
62PIM20.90341555
63PDK30.84954625
64PDK40.84954625
65MTOR0.84524650
66MAPK40.84021917
67PRKD10.81857609
68PDK20.81274174
69CAMK10.81235515
70LMTK20.81128404
71SCYL20.80779732
72TYRO30.78932482
73AKT30.78432123
74PRPF4B0.77978017
75MARK20.77272120
76CAMK1G0.75852426
77TIE10.75799441
78OBSCN0.75446581
79NLK0.75047783
80ROCK20.70914321
81GSK3A0.70642571
82TYK20.70344392
83RPS6KA20.68287562
84CAMK2G0.67739458
85TAOK10.67266615
86WNK40.67166407
87FLT30.67071482
88FRK0.65875953
89PKN10.60886589
90ABL20.59799004
91JAK30.57917076
92MST1R0.57821718
93FGFR30.54989065
94JAK10.54864030
95PRKCH0.54776717
96KIT0.54643864
97RET0.52901375
98MAP3K100.52790221
99STK100.52445538
100CDC42BPA0.51758421
101NEK10.51350133
102GRK10.50697233
103PHKG20.50502948
104PHKG10.50502948
105PAK10.50134557
106PRKD20.49547889
107PRKG20.49149185
108BCKDK0.48839717
109GRK70.48374072
110KSR20.47673202
111HIPK20.47670192
112ERBB40.46714153
113PDPK10.45663436
114CAMK2D0.44967717
115PRKD30.44666121
116DYRK1B0.44485196
117TAOK20.43955706
118ARAF0.43580578
119CDK60.43210132
120TESK20.42952445
121PRKAA10.42526175
122MAP3K130.40973075
123PRKG10.40776887
124DAPK30.38059438
125CAMK2B0.37080135
126MAPKAPK20.36922204
127INSR0.36712880
128WNK10.36189162
129SGK4940.35910837
130SGK2230.35910837
131PAK60.35723676
132STK240.35385605
133TBK10.34392803
134FGFR20.34257096
135MAP3K80.33975254
136RPS6KL10.32817660
137RPS6KC10.32817660
138CAMKK20.32665454
139SRC0.31441868
140MAPK120.30700739

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.47500593
2Focal adhesion_Homo sapiens_hsa045103.20751741
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.07831676
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.95671650
5Dilated cardiomyopathy_Homo sapiens_hsa054142.81657459
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.50810326
7Protein digestion and absorption_Homo sapiens_hsa049742.31544989
8Proteoglycans in cancer_Homo sapiens_hsa052052.29602534
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.18646694
10Amoebiasis_Homo sapiens_hsa051462.11903812
11Small cell lung cancer_Homo sapiens_hsa052221.99485672
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.96551295
13Viral myocarditis_Homo sapiens_hsa054161.94690274
14Adherens junction_Homo sapiens_hsa045201.93333217
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.89359847
16Malaria_Homo sapiens_hsa051441.87982155
17Bladder cancer_Homo sapiens_hsa052191.75281059
18TGF-beta signaling pathway_Homo sapiens_hsa043501.63461619
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54583023
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.52037351
21MicroRNAs in cancer_Homo sapiens_hsa052061.37310693
22Chronic myeloid leukemia_Homo sapiens_hsa052201.33689302
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.33543501
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30713896
25Regulation of actin cytoskeleton_Homo sapiens_hsa048101.24884049
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22034626
27Hippo signaling pathway_Homo sapiens_hsa043901.19829925
28Phenylalanine metabolism_Homo sapiens_hsa003601.18424923
29Pancreatic cancer_Homo sapiens_hsa052121.17611891
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.16482560
31PPAR signaling pathway_Homo sapiens_hsa033201.14182810
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13090614
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11535887
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.11454443
35Melanoma_Homo sapiens_hsa052181.09566887
36HIF-1 signaling pathway_Homo sapiens_hsa040661.08336134
37Shigellosis_Homo sapiens_hsa051311.06943815
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.05530541
39Prion diseases_Homo sapiens_hsa050201.04877947
40Fatty acid degradation_Homo sapiens_hsa000711.04757286
41Toxoplasmosis_Homo sapiens_hsa051451.04069111
42Renin secretion_Homo sapiens_hsa049241.01742121
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00009432
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95916462
45Adipocytokine signaling pathway_Homo sapiens_hsa049200.95295203
46Melanogenesis_Homo sapiens_hsa049160.94481892
47Glycerolipid metabolism_Homo sapiens_hsa005610.94296713
48Circadian rhythm_Homo sapiens_hsa047100.93277826
49Platelet activation_Homo sapiens_hsa046110.93011868
50Insulin resistance_Homo sapiens_hsa049310.91375296
51Histidine metabolism_Homo sapiens_hsa003400.89647729
52Tyrosine metabolism_Homo sapiens_hsa003500.88519414
53Fatty acid metabolism_Homo sapiens_hsa012120.88165395
54Pathways in cancer_Homo sapiens_hsa052000.87967494
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87216308
56Lysosome_Homo sapiens_hsa041420.86108447
57Phagosome_Homo sapiens_hsa041450.85987122
58Renin-angiotensin system_Homo sapiens_hsa046140.85704369
59Basal cell carcinoma_Homo sapiens_hsa052170.84854885
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84443312
61Caffeine metabolism_Homo sapiens_hsa002320.84073798
62Renal cell carcinoma_Homo sapiens_hsa052110.82990594
63Tight junction_Homo sapiens_hsa045300.82359256
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82017126
65Prostate cancer_Homo sapiens_hsa052150.81627919
66Rap1 signaling pathway_Homo sapiens_hsa040150.81569953
67Apoptosis_Homo sapiens_hsa042100.80149369
68Glioma_Homo sapiens_hsa052140.79031624
69AMPK signaling pathway_Homo sapiens_hsa041520.78197718
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75948955
71TNF signaling pathway_Homo sapiens_hsa046680.75832143
72Propanoate metabolism_Homo sapiens_hsa006400.73859858
73p53 signaling pathway_Homo sapiens_hsa041150.73546114
74HTLV-I infection_Homo sapiens_hsa051660.72854717
75Insulin signaling pathway_Homo sapiens_hsa049100.71539154
76Starch and sucrose metabolism_Homo sapiens_hsa005000.71125728
77Estrogen signaling pathway_Homo sapiens_hsa049150.70495690
78mTOR signaling pathway_Homo sapiens_hsa041500.69752115
79GnRH signaling pathway_Homo sapiens_hsa049120.69434302
80Carbon metabolism_Homo sapiens_hsa012000.69098352
81Pertussis_Homo sapiens_hsa051330.67403959
82VEGF signaling pathway_Homo sapiens_hsa043700.67113406
83Dorso-ventral axis formation_Homo sapiens_hsa043200.66727326
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66148316
85cAMP signaling pathway_Homo sapiens_hsa040240.65189338
86Hedgehog signaling pathway_Homo sapiens_hsa043400.65163415
87beta-Alanine metabolism_Homo sapiens_hsa004100.65058056
88Oxytocin signaling pathway_Homo sapiens_hsa049210.63706305
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.63637263
90Wnt signaling pathway_Homo sapiens_hsa043100.63171174
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62179764
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61745428
93Fatty acid biosynthesis_Homo sapiens_hsa000610.59774533
94Calcium signaling pathway_Homo sapiens_hsa040200.58927629
95Axon guidance_Homo sapiens_hsa043600.58650641
96Other glycan degradation_Homo sapiens_hsa005110.58287131
97Complement and coagulation cascades_Homo sapiens_hsa046100.56230158
98Salmonella infection_Homo sapiens_hsa051320.55904281
99Ovarian steroidogenesis_Homo sapiens_hsa049130.54336862
100Acute myeloid leukemia_Homo sapiens_hsa052210.54221051
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.53465318
102Lysine degradation_Homo sapiens_hsa003100.52866971
103Osteoclast differentiation_Homo sapiens_hsa043800.52835544
104Endometrial cancer_Homo sapiens_hsa052130.52770091
105Cocaine addiction_Homo sapiens_hsa050300.52036565
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51788354
107Colorectal cancer_Homo sapiens_hsa052100.51741820
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51683179
109Fatty acid elongation_Homo sapiens_hsa000620.50702713
110Hepatitis B_Homo sapiens_hsa051610.50158299
111Gastric acid secretion_Homo sapiens_hsa049710.48386795
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47844068
113Thyroid hormone synthesis_Homo sapiens_hsa049180.47295385
114Galactose metabolism_Homo sapiens_hsa000520.47269415
115FoxO signaling pathway_Homo sapiens_hsa040680.47177380
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46963270
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46715046
118Endocytosis_Homo sapiens_hsa041440.46712816
119Prolactin signaling pathway_Homo sapiens_hsa049170.45839032
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44080895
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44074650
122Pyruvate metabolism_Homo sapiens_hsa006200.43689932
123Glucagon signaling pathway_Homo sapiens_hsa049220.43179597
124Notch signaling pathway_Homo sapiens_hsa043300.42900257
125Gap junction_Homo sapiens_hsa045400.42844418
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42436579
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.42152878
128Choline metabolism in cancer_Homo sapiens_hsa052310.42109936
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41418389
130Thyroid cancer_Homo sapiens_hsa052160.40917899
131N-Glycan biosynthesis_Homo sapiens_hsa005100.39795163
132Ras signaling pathway_Homo sapiens_hsa040140.39053844
133Leishmaniasis_Homo sapiens_hsa051400.38634235
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38426948
135Viral carcinogenesis_Homo sapiens_hsa052030.38418290

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