ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.59802479
2	L-phenylalanine catabolic process (GO:0006559)	7.59802479
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.27433415
4	L-phenylalanine metabolic process (GO:0006558)	7.27433415
5	aromatic amino acid family catabolic process (GO:0009074)	6.68729110
6	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.51701576
7	regulation of plasminogen activation (GO:0010755)	6.14950684
8	indole-containing compound catabolic process (GO:0042436)	5.90987074
9	indolalkylamine catabolic process (GO:0046218)	5.90987074
10	tryptophan catabolic process (GO:0006569)	5.90987074
11	kynurenine metabolic process (GO:0070189)	5.79087235
12	bile acid biosynthetic process (GO:0006699)	5.76605971
13	glyoxylate metabolic process (GO:0046487)	5.73752829
14	high-density lipoprotein particle remodeling (GO:0034375)	5.73522471
15	urea cycle (GO:0000050)	5.60922133
16	urea metabolic process (GO:0019627)	5.60922133
17	tryptophan metabolic process (GO:0006568)	5.58692984
18	negative regulation of fibrinolysis (GO:0051918)	5.58621255
19	cysteine metabolic process (GO:0006534)	5.46981493
20	alpha-linolenic acid metabolic process (GO:0036109)	5.46822582
21	sulfur amino acid catabolic process (GO:0000098)	5.42645364
22	regulation of fibrinolysis (GO:0051917)	5.37536207
23	protein carboxylation (GO:0018214)	5.30489309
24	peptidyl-glutamic acid carboxylation (GO:0017187)	5.30489309
25	complement activation, alternative pathway (GO:0006957)	5.19975079
26	nitrogen cycle metabolic process (GO:0071941)	5.16627062
27	regulation of protein activation cascade (GO:2000257)	5.15847533
28	serine family amino acid catabolic process (GO:0009071)	5.10432253
29	reverse cholesterol transport (GO:0043691)	5.01722451
30	regulation of cholesterol esterification (GO:0010872)	4.99296832
31	bile acid metabolic process (GO:0008206)	4.96041656
32	protein-lipid complex remodeling (GO:0034368)	4.90995277
33	macromolecular complex remodeling (GO:0034367)	4.90995277
34	plasma lipoprotein particle remodeling (GO:0034369)	4.90995277
35	regulation of triglyceride catabolic process (GO:0010896)	4.90289172
36	acute-phase response (GO:0006953)	4.90142943
37	aromatic amino acid family metabolic process (GO:0009072)	4.86640042
38	regulation of complement activation (GO:0030449)	4.80665699
39	homocysteine metabolic process (GO:0050667)	4.78882114
40	negative regulation of blood coagulation (GO:0030195)	4.76418080
41	negative regulation of hemostasis (GO:1900047)	4.76418080
42	tyrosine metabolic process (GO:0006570)	4.74728197
43	phospholipid efflux (GO:0033700)	4.72605661
44	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.71157578
45	triglyceride homeostasis (GO:0070328)	4.68573257
46	acylglycerol homeostasis (GO:0055090)	4.68573257
47	negative regulation of cholesterol transport (GO:0032375)	4.66974128
48	negative regulation of sterol transport (GO:0032372)	4.66974128
49	alpha-amino acid catabolic process (GO:1901606)	4.64333290
50	epoxygenase P450 pathway (GO:0019373)	4.62818579
51	plasma lipoprotein particle clearance (GO:0034381)	4.60993922
52	lysine catabolic process (GO:0006554)	4.58971503
53	lysine metabolic process (GO:0006553)	4.58971503
54	protein-lipid complex subunit organization (GO:0071825)	4.58775603
55	amino-acid betaine metabolic process (GO:0006577)	4.48261890
56	glycine metabolic process (GO:0006544)	4.47001709
57	coenzyme catabolic process (GO:0009109)	4.42909130
58	negative regulation of protein activation cascade (GO:2000258)	4.42471301
59	cellular ketone body metabolic process (GO:0046950)	4.42246763
60	negative regulation of coagulation (GO:0050819)	4.36870175
61	cellular amino acid catabolic process (GO:0009063)	4.29907758
62	cholesterol efflux (GO:0033344)	4.28538309
63	imidazole-containing compound metabolic process (GO:0052803)	4.27390786
64	negative regulation of wound healing (GO:0061045)	4.27356085
65	bile acid and bile salt transport (GO:0015721)	4.25310772
66	glutamate metabolic process (GO:0006536)	4.23522795
67	serine family amino acid metabolic process (GO:0009069)	4.23096698
68	positive regulation of blood coagulation (GO:0030194)	4.21882795
69	positive regulation of hemostasis (GO:1900048)	4.21882795
70	regulation of lipoprotein particle clearance (GO:0010984)	4.21718606
71	indolalkylamine metabolic process (GO:0006586)	4.19686115
72	positive regulation of fatty acid biosynthetic process (GO:0045723)	4.18867250
73	cellular modified amino acid catabolic process (GO:0042219)	4.16026214
74	regulation of humoral immune response (GO:0002920)	4.15952288
75	plasma lipoprotein particle assembly (GO:0034377)	4.13166259
76	serine family amino acid biosynthetic process (GO:0009070)	4.12769130
77	ethanol metabolic process (GO:0006067)	4.11711422
78	amine catabolic process (GO:0009310)	4.11369646
79	cellular biogenic amine catabolic process (GO:0042402)	4.11369646
80	cellular glucuronidation (GO:0052695)	4.10967806
81	low-density lipoprotein particle remodeling (GO:0034374)	4.09177087
82	ethanol oxidation (GO:0006069)	4.03876843
83	regulation of apoptotic cell clearance (GO:2000425)	4.03166618
84	benzene-containing compound metabolic process (GO:0042537)	4.00351042
85	omega-hydroxylase P450 pathway (GO:0097267)	3.97418925
86	arginine metabolic process (GO:0006525)	3.96998089
87	aldehyde catabolic process (GO:0046185)	3.95224415
88	proline metabolic process (GO:0006560)	3.94092711
89	dicarboxylic acid biosynthetic process (GO:0043650)	3.93818716
90	fibrinolysis (GO:0042730)	3.92691668
91	acute inflammatory response (GO:0002526)	3.92329678
92	positive regulation of lipoprotein lipase activity (GO:0051006)	3.87629345
93	positive regulation of triglyceride lipase activity (GO:0061365)	3.87629345
94	positive regulation of coagulation (GO:0050820)	3.86743726
95	very-low-density lipoprotein particle assembly (GO:0034379)	3.84683194
96	ketone body metabolic process (GO:1902224)	3.82494214
97	negative regulation of complement activation (GO:0045916)	3.81811185
98	negative regulation of lipase activity (GO:0060192)	3.81009604
99	phenylpropanoid metabolic process (GO:0009698)	3.80538578
100	positive regulation of lipid catabolic process (GO:0050996)	3.79604217
101	cholesterol homeostasis (GO:0042632)	3.79121814
102	cofactor catabolic process (GO:0051187)	3.78162263
103	drug catabolic process (GO:0042737)	3.77428339
104	blood coagulation, intrinsic pathway (GO:0007597)	3.77401135
105	carboxylic acid catabolic process (GO:0046395)	3.76880099
106	organic acid catabolic process (GO:0016054)	3.76880099
107	drug metabolic process (GO:0017144)	3.76298257
108	intestinal cholesterol absorption (GO:0030299)	3.75819650
109	phospholipid homeostasis (GO:0055091)	3.75613750
110	short-chain fatty acid metabolic process (GO:0046459)	3.73670686
111	plasma lipoprotein particle organization (GO:0071827)	3.73405233
112	sterol homeostasis (GO:0055092)	3.72712536
113	acylglycerol catabolic process (GO:0046464)	3.70703844
114	neutral lipid catabolic process (GO:0046461)	3.70703844
115	low-density lipoprotein particle clearance (GO:0034383)	3.70643878
116	protein-lipid complex assembly (GO:0065005)	3.70560703
117	exogenous drug catabolic process (GO:0042738)	3.67360688
118	regulation of bile acid biosynthetic process (GO:0070857)	3.67279533
119	acetyl-CoA metabolic process (GO:0006084)	3.66720532
120	positive regulation of steroid metabolic process (GO:0045940)	3.65111240
121	glucuronate metabolic process (GO:0019585)	3.64165836
122	uronic acid metabolic process (GO:0006063)	3.64165836
123	diacylglycerol metabolic process (GO:0046339)	3.63613468
124	complement activation, classical pathway (GO:0006958)	3.63385748
125	complement activation (GO:0006956)	3.61213215
126	protein activation cascade (GO:0072376)	3.61159691
127	positive regulation of extracellular matrix organization (GO:1903055)	3.58970008
128	regulation of cholesterol homeostasis (GO:2000188)	3.57387227
129	aspartate family amino acid catabolic process (GO:0009068)	3.52488080
130	cytolysis (GO:0019835)	3.52394447
131	fatty acid homeostasis (GO:0055089)	3.48863783
132	lipoprotein metabolic process (GO:0042157)	3.45510447
133	triglyceride catabolic process (GO:0019433)	3.40191149
134	sterol transport (GO:0015918)	3.37409985
135	cholesterol transport (GO:0030301)	3.37409985
136	oxidative demethylation (GO:0070989)	3.35966792
137	regulation of triglyceride metabolic process (GO:0090207)	3.34258230

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	8.33726588
2	PPARA_22158963_ChIP-Seq_LIVER_Mouse	7.18336134
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.89678513
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	6.46907833
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.26886080
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	5.20019843
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	5.12260691
8	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.97439588
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.95531797
10	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.14643409
11	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.05960391
12	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.03292371
13	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.9264963
14	CLOCK_20551151_ChIP-Seq_293T_Human	1.64392570
15	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.61943745
16	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.57775152
17	HTT_18923047_ChIP-ChIP_STHdh_Human	1.52744224
18	GATA1_22025678_ChIP-Seq_K562_Human	1.47479690
19	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.39275414
20	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.35417271
21	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.23704106
22	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.23443027
23	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.20908697
24	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.20212970
25	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.11652123
26	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.03270971
27	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.02931876
28	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.02593108
29	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.98251952
30	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.97186828
31	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.96719429
32	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.95114591
33	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.93576916
34	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.92863992
35	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.91056952
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.91046522
37	RAC3_21632823_ChIP-Seq_H3396_Human	0.90925759
38	SMC4_20622854_ChIP-Seq_HELA_Human	0.88047678
39	GATA4_25053715_ChIP-Seq_YYC3_Human	0.86556707
40	ZNF263_19887448_ChIP-Seq_K562_Human	0.83729815
41	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.83086930
42	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.81364438
43	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.80186915
44	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.78946255
45	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.78095403
46	CTCF_27219007_Chip-Seq_Bcells_Human	0.76813781
47	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.75869514
48	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.74242374
49	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.73560064
50	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.72779349
51	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.72145177
52	SOX2_20726797_ChIP-Seq_SW620_Human	0.71995517
53	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.71625137
54	SOX2_21211035_ChIP-Seq_LN229_Human	0.71608707
55	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.71480023
56	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.71464669
57	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.71424177
58	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.71239182
59	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.70465777
60	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.69515404
61	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.68879040
62	SA1_27219007_Chip-Seq_Bcells_Human	0.68583911
63	P68_20966046_ChIP-Seq_HELA_Human	0.67394692
64	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.66887628
65	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.66823869
66	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.65858391
67	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.65736801
68	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.65575036
69	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.65504796
70	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.65214639
71	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.65149545
72	E2F1_20622854_ChIP-Seq_HELA_Human	0.64741791
73	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.64575438
74	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.63566646
75	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.62911277
76	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.62767975
77	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.62505725
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.62004097
79	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.61682793
80	LXR_22292898_ChIP-Seq_THP-1_Human	0.61590695
81	SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.60739962
82	RACK7_27058665_Chip-Seq_MCF-7_Human	0.60694293
83	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.59713018
84	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.59646740
85	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.59531736
86	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.59419764
87	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.59411101
88	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.59411101
89	CEBPB_22108803_ChIP-Seq_LS180_Human	0.58591827
90	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.58079367
91	EGR1_19032775_ChIP-ChIP_M12_Human	0.57008549
92	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.56860608
93	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.54515333
94	BCL6_27268052_Chip-Seq_Bcells_Human	0.53989287
95	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.53946321
96	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.53598787
97	ERA_21632823_ChIP-Seq_H3396_Human	0.53399152
98	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.53101015
99	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.52968649
100	AR_20517297_ChIP-Seq_VCAP_Human	0.52449413
101	MYC_19915707_ChIP-ChIP_AK7_Human	0.52194315
102	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.51454710
103	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.51340813
104	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.51319576
105	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.50987001
106	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.50625598
107	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.50378870
108	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.48935728
109	P53_21459846_ChIP-Seq_SAOS-2_Human	0.48103385
110	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.47311774
111	CBP_21632823_ChIP-Seq_H3396_Human	0.45848750
112	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.45567365
113	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.45461494
114	GATA6_25053715_ChIP-Seq_YYC3_Human	0.44977898
115	GATA1_19941826_ChIP-Seq_K562_Human	0.44819399
116	TAF2_19829295_ChIP-Seq_ESCs_Human	0.44134831
117	STAT1_17558387_ChIP-Seq_HELA_Human	0.43332670
118	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.42788949
119	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.42427399
120	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.41872657
121	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.41820047
122	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.41796538
123	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.40174507
124	GATA2_19941826_ChIP-Seq_K562_Human	0.39632090
125	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.37361285
126	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.36486953
127	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.36396219
128	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.36003374
129	BCAT_22108803_ChIP-Seq_LS180_Human	0.35572280
130	ERG_20517297_ChIP-Seq_VCAP_Human	0.35466462
131	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.35286815
132	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.35230985
133	SPI1_26923725_Chip-Seq_HPCs_Mouse	0.35023388
134	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.34975293
135	OCT4_20526341_ChIP-Seq_ESCs_Human	0.34612628
136	BCOR_27268052_Chip-Seq_Bcells_Human	0.34608793
137	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.33934872

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.22543058
2	MP0005360_urolithiasis	7.43400891
3	MP0005085_abnormal_gallbladder_physiolo	6.35302228
4	MP0005365_abnormal_bile_salt	6.28021443
5	MP0008875_abnormal_xenobiotic_pharmacok	4.96664006
6	MP0003806_abnormal_nucleotide_metabolis	4.18471818
7	MP0003252_abnormal_bile_duct	3.76141948
8	MP0010329_abnormal_lipoprotein_level	3.67347380
9	MP0005083_abnormal_biliary_tract	3.40982096
10	MP0009840_abnormal_foam_cell	3.34809847
11	MP0001666_abnormal_nutrient_absorption	2.89394014
12	MP0005332_abnormal_amino_acid	2.76409780
13	MP0003195_calcinosis	2.76027577
14	MP0003191_abnormal_cellular_cholesterol	2.35494667
15	MP0002118_abnormal_lipid_homeostasis	2.17052678
16	MP0000609_abnormal_liver_physiology	2.16975765
17	MP0004019_abnormal_vitamin_homeostasis	2.09614471
18	MP0003122_maternal_imprinting	1.96425606
19	MP0003868_abnormal_feces_composition	1.96393477
20	MP0000566_synostosis	1.88091707
21	MP0002138_abnormal_hepatobiliary_system	1.85362507
22	MP0005319_abnormal_enzyme/_coenzyme	1.81534793
23	MP0001764_abnormal_homeostasis	1.69680063
24	MP0009697_abnormal_copulation	1.60353444
25	MP0005584_abnormal_enzyme/coenzyme_acti	1.56126329
26	MP0005451_abnormal_body_composition	1.45801163
27	MP0003186_abnormal_redox_activity	1.32383288
28	MP0003011_delayed_dark_adaptation	1.31577914
29	MP0002089_abnormal_postnatal_growth/wei	1.30843900
30	MP0009643_abnormal_urine_homeostasis	1.26122282
31	MP0005058_abnormal_lysosome_morphology	1.25670630
32	MP0003656_abnormal_erythrocyte_physiolo	1.23835163
33	MP0003705_abnormal_hypodermis_morpholog	1.23669696
34	MP0000598_abnormal_liver_morphology	1.18375740
35	MP0001915_intracranial_hemorrhage	1.13541389
36	MP0005647_abnormal_sex_gland	1.11752030
37	MP0000604_amyloidosis	1.09494540
38	MP0005167_abnormal_blood-brain_barrier	1.08419157
39	MP0000003_abnormal_adipose_tissue	1.06432395
40	MP0005375_adipose_tissue_phenotype	1.05243837
41	MP0004185_abnormal_adipocyte_glucose	1.02222291
42	MP0002132_abnormal_respiratory_system	1.02118591
43	MP0009763_increased_sensitivity_to	1.01262273
44	MP0002254_reproductive_system_inflammat	1.01228398
45	MP0005220_abnormal_exocrine_pancreas	1.00069235
46	MP0009764_decreased_sensitivity_to	0.98742502
47	MP0010368_abnormal_lymphatic_system	0.95606122
48	MP0005084_abnormal_gallbladder_morpholo	0.94298850
49	MP0005636_abnormal_mineral_homeostasis	0.91752785
50	MP0003879_abnormal_hair_cell	0.91553775
51	MP0008469_abnormal_protein_level	0.88409339
52	MP0003172_abnormal_lysosome_physiology	0.88341638
53	MP0006036_abnormal_mitochondrial_physio	0.87824940
54	MP0009642_abnormal_blood_homeostasis	0.87731851
55	MP0005408_hypopigmentation	0.85250590
56	MP0002078_abnormal_glucose_homeostasis	0.84222990
57	MP0002876_abnormal_thyroid_physiology	0.82228347
58	MP0005376_homeostasis/metabolism_phenot	0.79530768
59	MP0005670_abnormal_white_adipose	0.79232743
60	MP0004130_abnormal_muscle_cell	0.78405605
61	MP0009765_abnormal_xenobiotic_induced	0.78390768
62	MP0002971_abnormal_brown_adipose	0.77909628
63	MP0004272_abnormal_basement_membrane	0.76296279
64	MP0005334_abnormal_fat_pad	0.74606868
65	MP0005535_abnormal_body_temperature	0.73956005
66	MP0010386_abnormal_urinary_bladder	0.71088056
67	MP0001661_extended_life_span	0.68218416
68	MP0003329_amyloid_beta_deposits	0.65761385
69	MP0005448_abnormal_energy_balance	0.65316677
70	MP0003690_abnormal_glial_cell	0.65075739
71	MP0005266_abnormal_metabolism	0.64099545
72	MP0009053_abnormal_anal_canal	0.63692199
73	MP0002909_abnormal_adrenal_gland	0.62514911
74	MP0005379_endocrine/exocrine_gland_phen	0.62140028
75	MP0000639_abnormal_adrenal_gland	0.60871817
76	MP0005257_abnormal_intraocular_pressure	0.58461990
77	MP0001756_abnormal_urination	0.57206265
78	MP0003123_paternal_imprinting	0.56760914
79	MP0009780_abnormal_chondrocyte_physiolo	0.56469006
80	MP0006035_abnormal_mitochondrial_morpho	0.54549623
81	MP0008438_abnormal_cutaneous_collagen	0.52428289
82	MP0003638_abnormal_response/metabolism_	0.50864171
83	MP0003567_abnormal_fetal_cardiomyocyte	0.50722638
84	MP0005464_abnormal_platelet_physiology	0.49825541
85	MP0002837_dystrophic_cardiac_calcinosis	0.49039460
86	MP0002822_catalepsy	0.47388731
87	MP0002933_joint_inflammation	0.46288175
88	MP0003953_abnormal_hormone_level	0.45262786
89	MP0005395_other_phenotype	0.45096767
90	MP0003718_maternal_effect	0.44726097
91	MP0002928_abnormal_bile_duct	0.43960922
92	MP0005666_abnormal_adipose_tissue	0.42988488
93	MP0002136_abnormal_kidney_physiology	0.42902118
94	MP0008873_increased_physiological_sensi	0.42812907
95	MP0008874_decreased_physiological_sensi	0.42713647
96	MP0004782_abnormal_surfactant_physiolog	0.42222072
97	MP0003724_increased_susceptibility_to	0.41701661
98	MP0003436_decreased_susceptibility_to	0.41364144
99	MP0003075_altered_response_to	0.40703149
100	MP0009672_abnormal_birth_weight	0.40662085
101	MP0005452_abnormal_adipose_tissue	0.40444855
102	MP0000858_altered_metastatic_potential	0.40307990
103	MP0005377_hearing/vestibular/ear_phenot	0.38177891
104	MP0003878_abnormal_ear_physiology	0.38177891
105	MP0008872_abnormal_physiological_respon	0.37899879
106	MP0002970_abnormal_white_adipose	0.36901086
107	MP0005248_abnormal_Harderian_gland	0.36463141
108	MP0009115_abnormal_fat_cell	0.35970185
109	MP0002796_impaired_skin_barrier	0.35338203
110	MP0002249_abnormal_larynx_morphology	0.34962961
111	MP0005166_decreased_susceptibility_to	0.34946471
112	MP0005409_darkened_coat_color	0.34391040
113	MP0002090_abnormal_vision	0.33567877
114	MP0001243_abnormal_dermal_layer	0.33457563
115	MP0000249_abnormal_blood_vessel	0.33072047
116	MP0000920_abnormal_myelination	0.32585086
117	MP0003950_abnormal_plasma_membrane	0.32078724
118	MP0001881_abnormal_mammary_gland	0.30747665
119	MP0003959_abnormal_lean_body	0.30544960
120	MP0000579_abnormal_nail_morphology	0.30319270
121	MP0000230_abnormal_systemic_arterial	0.30297210
122	MP0004883_abnormal_blood_vessel	0.30090725
123	MP0009384_cardiac_valve_regurgitation	0.29335626
124	MP0001845_abnormal_inflammatory_respons	0.28846790
125	MP0005023_abnormal_wound_healing	0.28821093
126	MP0001944_abnormal_pancreas_morphology	0.27863805
127	MP0004381_abnormal_hair_follicle	0.27607546
128	MP0002168_other_aberrant_phenotype	0.27375327
129	MP0001853_heart_inflammation	0.26412976
130	MP0006082_CNS_inflammation	0.26160140
131	MP0002060_abnormal_skin_morphology	0.25947602
132	MP0005164_abnormal_response_to	0.25334409

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.46656930
2	Deep venous thrombosis (HP:0002625)	7.38446828
3	Intrahepatic cholestasis (HP:0001406)	7.06928354
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.50847875
5	Hypobetalipoproteinemia (HP:0003563)	6.50310594
6	Prolonged partial thromboplastin time (HP:0003645)	6.48593507
7	Xanthomatosis (HP:0000991)	6.26856347
8	Hyperlipoproteinemia (HP:0010980)	5.64815839
9	Complement deficiency (HP:0004431)	5.13374207
10	Hypolipoproteinemia (HP:0010981)	4.87884153
11	Joint hemorrhage (HP:0005261)	4.76926506
12	Hyperammonemia (HP:0001987)	4.63070207
13	Hyperglycinemia (HP:0002154)	4.50332162
14	Abnormality of the common coagulation pathway (HP:0010990)	4.46148384
15	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.44944076
16	Epidermoid cyst (HP:0200040)	4.44246684
17	Ketosis (HP:0001946)	4.38765848
18	Hypoalphalipoproteinemia (HP:0003233)	4.25442236
19	Abnormality of methionine metabolism (HP:0010901)	4.23367315
20	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.21954803
21	Fat malabsorption (HP:0002630)	4.17482290
22	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.13481508
23	Hyperglycinuria (HP:0003108)	4.11851534
24	Hypoglycemic coma (HP:0001325)	4.10004960
25	Abnormality of glycine metabolism (HP:0010895)	4.07711270
26	Abnormality of serine family amino acid metabolism (HP:0010894)	4.07711270
27	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.07483874
28	Abnormality of the intrinsic pathway (HP:0010989)	3.89663638
29	Abnormality of complement system (HP:0005339)	3.74421122
30	Abnormality of pyrimidine metabolism (HP:0004353)	3.69853039
31	Hypercholesterolemia (HP:0003124)	3.61286776
32	Conjugated hyperbilirubinemia (HP:0002908)	3.54284709
33	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.43341313
34	Abnormality of fatty-acid metabolism (HP:0004359)	3.40966845
35	Hyperbilirubinemia (HP:0002904)	3.28160786
36	Steatorrhea (HP:0002570)	3.20748429
37	Ketoacidosis (HP:0001993)	3.18407448
38	Purpura (HP:0000979)	3.16598604
39	Abnormality of serum amino acid levels (HP:0003112)	3.10975657
40	Delayed CNS myelination (HP:0002188)	3.08137248
41	Abnormality of nucleobase metabolism (HP:0010932)	3.01118680
42	Myocardial infarction (HP:0001658)	2.99055254
43	Nephritis (HP:0000123)	2.97017711
44	Spontaneous abortion (HP:0005268)	2.91787438
45	Hepatocellular carcinoma (HP:0001402)	2.90536730
46	Hypochromic microcytic anemia (HP:0004840)	2.86211339
47	Metabolic acidosis (HP:0001942)	2.80084781
48	Skin nodule (HP:0200036)	2.76028461
49	Dicarboxylic aciduria (HP:0003215)	2.70451929
50	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.70451929
51	Hypoglycemic seizures (HP:0002173)	2.67764890
52	Abnormality of purine metabolism (HP:0004352)	2.66751500
53	Lethargy (HP:0001254)	2.65245297
54	Systemic lupus erythematosus (HP:0002725)	2.63174282
55	Acanthocytosis (HP:0001927)	2.55225988
56	Vascular calcification (HP:0004934)	2.54314322
57	Gout (HP:0001997)	2.51335468
58	Cerebral edema (HP:0002181)	2.50637009
59	Facial shape deformation (HP:0011334)	2.47508771
60	Potter facies (HP:0002009)	2.47508771
61	Reduced antithrombin III activity (HP:0001976)	2.47471299
62	Spastic diplegia (HP:0001264)	2.43263912
63	Abnormal gallbladder morphology (HP:0012437)	2.40547357
64	Glomerulonephritis (HP:0000099)	2.38989425
65	Mitral stenosis (HP:0001718)	2.35486273
66	Abnormality of carpal bone ossification (HP:0006257)	2.34180988
67	Cholelithiasis (HP:0001081)	2.33835298
68	Neonatal onset (HP:0003623)	2.30572616
69	Amyloidosis (HP:0011034)	2.30367956
70	Irritability (HP:0000737)	2.29139319
71	Cardiovascular calcification (HP:0011915)	2.25921068
72	Pancreatitis (HP:0001733)	2.25900279
73	Hypertriglyceridemia (HP:0002155)	2.22726715
74	Osteomalacia (HP:0002749)	2.22166594
75	Malnutrition (HP:0004395)	2.21543455
76	Late onset (HP:0003584)	2.21537463
77	Esophageal varix (HP:0002040)	2.20849575
78	Abnormality of the Achilles tendon (HP:0005109)	2.20736678
79	Pulmonary embolism (HP:0002204)	2.19744690
80	Abnormal gallbladder physiology (HP:0012438)	2.19697261
81	Cholecystitis (HP:0001082)	2.19697261
82	Asymmetry of the thorax (HP:0001555)	2.18737211
83	Recurrent gram-negative bacterial infections (HP:0005420)	2.18015880
84	Menorrhagia (HP:0000132)	2.17255851
85	Hyperinsulinemic hypoglycemia (HP:0000825)	2.16697828
86	Brushfield spots (HP:0001088)	2.15529122
87	Increased serum pyruvate (HP:0003542)	2.14635333
88	Gingival bleeding (HP:0000225)	2.14301830
89	Vomiting (HP:0002013)	2.11634753
90	Sensorimotor neuropathy (HP:0007141)	2.07513838
91	Generalized aminoaciduria (HP:0002909)	2.07161316
92	Thrombophlebitis (HP:0004418)	2.06086790
93	Enlarged kidneys (HP:0000105)	2.05987837
94	Arthropathy (HP:0003040)	2.04168308
95	Opisthotonus (HP:0002179)	2.03840736
96	Hemorrhage of the eye (HP:0011885)	2.00635681
97	Poikilocytosis (HP:0004447)	1.99437373
98	Hydroxyprolinuria (HP:0003080)	1.96394464
99	Abnormality of proline metabolism (HP:0010907)	1.96394464
100	Abnormality of the gallbladder (HP:0005264)	1.94700357
101	Abnormal cartilage morphology (HP:0002763)	1.93130346
102	Abnormality of iron homeostasis (HP:0011031)	1.92972613
103	Abnormality of transition element cation homeostasis (HP:0011030)	1.92874930
104	Protrusio acetabuli (HP:0003179)	1.92138091
105	Abnormality of glycolysis (HP:0004366)	1.87328287
106	Rickets (HP:0002748)	1.85046359
107	Polycythemia (HP:0001901)	1.84948358
108	Renal cortical cysts (HP:0000803)	1.84589430
109	Growth hormone excess (HP:0000845)	1.84347459
110	Retinal atrophy (HP:0001105)	1.82558269
111	Bifid scrotum (HP:0000048)	1.82542060
112	Hyperglycemia (HP:0003074)	1.80537282
113	Hypophosphatemic rickets (HP:0004912)	1.79518615
114	Elevated hepatic transaminases (HP:0002910)	1.79142372
115	Pancreatic islet-cell hyperplasia (HP:0004510)	1.78010595
116	Alkalosis (HP:0001948)	1.76077594
117	Acute hepatic failure (HP:0006554)	1.74500779
118	Abnormality of vitamin metabolism (HP:0100508)	1.74054815
119	Abnormal enzyme/coenzyme activity (HP:0012379)	1.73877004
120	Widely patent fontanelles and sutures (HP:0004492)	1.73322853
121	Symptomatic seizures (HP:0011145)	1.73038552
122	Increased serum ferritin (HP:0003281)	1.68910245
123	Vertebral compression fractures (HP:0002953)	1.67359498
124	Abnormal hand bone ossification (HP:0010660)	1.66837015
125	Abnormal tarsal ossification (HP:0008369)	1.66581862
126	Abnormal ossification of hand bones (HP:0005921)	1.66467827
127	Acanthosis nigricans (HP:0000956)	1.65939280
128	Proximal tubulopathy (HP:0000114)	1.64876342
129	Gangrene (HP:0100758)	1.61759382
130	Paraparesis (HP:0002385)	1.60618669
131	Epistaxis (HP:0000421)	1.60284352
132	Back pain (HP:0003418)	1.59696824
133	Abnormality of pain sensation (HP:0010832)	1.57431098
134	Impaired pain sensation (HP:0007328)	1.57431098
135	Menstrual irregularities (HP:0000858)	1.57144169
136	Flat acetabular roof (HP:0003180)	1.55607796
137	Urinary glycosaminoglycan excretion (HP:0003541)	1.52964114
138	Mucopolysacchariduria (HP:0008155)	1.52964114

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	7.76778408
2	SIK1	5.04053299
3	ERN1	4.56826455
4	FGFR4	4.37100593
5	TESK2	4.05354641
6	INSRR	2.84402307
7	TAOK3	2.80686912
8	ERBB4	2.62123846
9	PKN2	2.47432450
10	MST1R	2.10117658
11	TRIB3	2.09874664
12	WNK4	2.08039362
13	MAP2K4	2.04996007
14	PDGFRA	1.97107365
15	FLT3	1.95288513
16	PIK3CG	1.83219849
17	MAPK11	1.77783812
18	DDR2	1.73250545
19	MAPKAPK3	1.66096476
20	TYK2	1.58047422
21	DAPK2	1.55858189
22	PTK6	1.49476740
23	TYRO3	1.48943021
24	LATS1	1.44419049
25	FRK	1.36421251
26	ABL2	1.35850892
27	KDR	1.31462221
28	FGFR1	1.30783200
29	NEK9	1.29474796
30	FGFR2	1.25915550
31	JAK2	1.17073364
32	PRKAA2	1.11996622
33	MAP3K7	1.11426547
34	PINK1	1.09988816
35	GRK6	1.07655405
36	MAP2K3	1.05008923
37	TBK1	0.99956072
38	MAPK15	0.97803978
39	CAMK1D	0.96138229
40	MAP3K10	0.94402799
41	JAK1	0.92523424
42	MAP3K3	0.91553818
43	CDK12	0.90395609
44	MAPK4	0.89288948
45	ARAF	0.87706340
46	PRKCZ	0.87432612
47	MET	0.86642920
48	NTRK3	0.86106942
49	ERBB2	0.85007735
50	MAP3K14	0.84468240
51	TIE1	0.80746657
52	CDK6	0.79906778
53	EEF2K	0.79036319
54	MAP3K11	0.78915694
55	MAPK12	0.77882465
56	SIK2	0.77521671
57	EPHB1	0.75051080
58	RIPK1	0.75029076
59	PRKACG	0.72861109
60	DYRK1B	0.72422171
61	MAP2K6	0.71290747
62	EIF2AK1	0.70122450
63	STK38L	0.69640779
64	IRAK3	0.66487260
65	GSK3A	0.66273492
66	PRKAA1	0.66254462
67	CSK	0.64301488
68	CAMK2G	0.63410323
69	EPHA3	0.62385561
70	WNK1	0.62212048
71	SGK1	0.61701020
72	STK16	0.60583000
73	TGFBR2	0.59758019
74	LATS2	0.59071767
75	PTK2	0.55020281
76	PRKG1	0.54947679
77	CDK7	0.52869548
78	PDPK1	0.52506366
79	MAP2K1	0.51941176
80	CAMKK2	0.51843492
81	TAOK2	0.50585429
82	FGFR3	0.49503460
83	IKBKE	0.47286761
84	PRKCQ	0.47268928
85	CAMKK1	0.47267708
86	MAPK7	0.46821056
87	MARK2	0.46741800
88	CSF1R	0.46633856
89	MAP2K2	0.46627669
90	PRKACA	0.46623388
91	SGK3	0.44793515
92	CSNK1G1	0.43812738
93	CDC42BPA	0.43224534
94	MAP3K2	0.43008783
95	CDK4	0.42635199
96	IGF1R	0.41167710
97	MTOR	0.40559102
98	RET	0.40154153
99	EPHA4	0.39563812
100	CSNK1E	0.39396752
101	SRC	0.39075436
102	MYLK	0.38797442
103	CAMK1G	0.38742250
104	GRK1	0.38517230
105	CSNK1D	0.37821817
106	KSR2	0.37383387
107	RPS6KA3	0.36826106
108	AKT3	0.36092328
109	PDK4	0.34784090
110	PDK3	0.34784090
111	ICK	0.34399790
112	MAP3K13	0.34291515
113	MAP3K5	0.34148506
114	CSNK2A2	0.33238469
115	PDK1	0.32367730
116	PRKCG	0.31902373
117	PIK3CA	0.31483891
118	SMG1	0.31195582
119	PIM2	0.30194954
120	PKN1	0.30122777
121	CSNK2A1	0.29995956
122	CAMK4	0.28862763
123	EGFR	0.28685883
124	MUSK	0.28168499
125	MAP3K6	0.27595395
126	PRPF4B	0.27516758
127	SGK2	0.26864869
128	NTRK1	0.26674331
129	CSNK1G2	0.26648080
130	GRK5	0.26274969
131	PDGFRB	0.26172267
132	PRKACB	0.26045837
133	CSNK1G3	0.24626428
134	MAP3K1	0.23442433
135	BMX	0.23128024
136	PRKCA	0.22771288
137	ZAP70	0.21929025
138	SGK494	0.21867299
139	SGK223	0.21867299
140	PBK	0.20914246
141	MAPK3	0.20298844
142	ABL1	0.19341527

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.39097973
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.58186015
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.30713247
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.27132384
5	Arginine biosynthesis_Homo sapiens_hsa00220	3.05373926
6	Complement and coagulation cascades_Homo sapiens_hsa04610	2.70962514
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.67623025
8	Tryptophan metabolism_Homo sapiens_hsa00380	2.64415340
9	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.62066292
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.61002939
11	Fatty acid degradation_Homo sapiens_hsa00071	2.50189697
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.47241267
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.19667491
14	Butanoate metabolism_Homo sapiens_hsa00650	2.15530602
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.09986860
16	Peroxisome_Homo sapiens_hsa04146	2.06276127
17	Propanoate metabolism_Homo sapiens_hsa00640	2.03258555
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.93399453
19	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.90732717
20	Histidine metabolism_Homo sapiens_hsa00340	1.87899190
21	PPAR signaling pathway_Homo sapiens_hsa03320	1.87564066
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.86659756
23	Fatty acid metabolism_Homo sapiens_hsa01212	1.83511533
24	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.73142730
25	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.72455857
26	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.72415211
27	beta-Alanine metabolism_Homo sapiens_hsa00410	1.70465394
28	Caffeine metabolism_Homo sapiens_hsa00232	1.69162220
29	Retinol metabolism_Homo sapiens_hsa00830	1.64604207
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.62054602
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.61223104
32	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.60035572
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.58987960
34	Phenylalanine metabolism_Homo sapiens_hsa00360	1.53609871
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.51425950
36	Bile secretion_Homo sapiens_hsa04976	1.45753203
37	Tyrosine metabolism_Homo sapiens_hsa00350	1.41814285
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.39965242
39	Sulfur metabolism_Homo sapiens_hsa00920	1.39618503
40	Fat digestion and absorption_Homo sapiens_hsa04975	1.38387447
41	Folate biosynthesis_Homo sapiens_hsa00790	1.31939311
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31484876
43	Fatty acid elongation_Homo sapiens_hsa00062	1.31387248
44	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.29295998
45	Steroid biosynthesis_Homo sapiens_hsa00100	1.25007070
46	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.23586583
47	Carbon metabolism_Homo sapiens_hsa01200	1.17310310
48	ABC transporters_Homo sapiens_hsa02010	1.13902931
49	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.10109814
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.08336966
51	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.03926362
52	Arginine and proline metabolism_Homo sapiens_hsa00330	1.00877780
53	Sulfur relay system_Homo sapiens_hsa04122	0.99430592
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.97310225
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.91922094
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.89219539
57	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.85401177
58	Other glycan degradation_Homo sapiens_hsa00511	0.82494729
59	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.81591047
60	Lysine degradation_Homo sapiens_hsa00310	0.79717931
61	One carbon pool by folate_Homo sapiens_hsa00670	0.78464057
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77900658
63	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.70865293
64	Glutathione metabolism_Homo sapiens_hsa00480	0.67783613
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.59504252
66	Pentose phosphate pathway_Homo sapiens_hsa00030	0.58671273
67	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.57862786
68	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.57666325
69	Metabolic pathways_Homo sapiens_hsa01100	0.47240678
70	Pertussis_Homo sapiens_hsa05133	0.38998313
71	Prion diseases_Homo sapiens_hsa05020	0.32273596
72	Galactose metabolism_Homo sapiens_hsa00052	0.31322924
73	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.28620829
74	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.27010634
75	Linoleic acid metabolism_Homo sapiens_hsa00591	0.24871934
76	Insulin resistance_Homo sapiens_hsa04931	0.24237047
77	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.21759736
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.19719925
79	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.18631031
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.16481666
81	Sphingolipid metabolism_Homo sapiens_hsa00600	0.15143200
82	Glucagon signaling pathway_Homo sapiens_hsa04922	0.09814965
83	Mineral absorption_Homo sapiens_hsa04978	0.05994373
84	AMPK signaling pathway_Homo sapiens_hsa04152	0.03317285
85	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.01223061
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.00838210
87	Bladder cancer_Homo sapiens_hsa05219	-0.2386665
88	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	-0.2357747
89	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	-0.2348457
90	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.2127695
91	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.1885801
92	Hepatitis C_Homo sapiens_hsa05160	-0.1870631
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.1786224
94	Regulation of autophagy_Homo sapiens_hsa04140	-0.1675665
95	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.1660958
96	African trypanosomiasis_Homo sapiens_hsa05143	-0.1619293
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.1547970
98	Protein digestion and absorption_Homo sapiens_hsa04974	-0.1477172
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.1430011
100	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.1283737
101	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1234919
102	Renin-angiotensin system_Homo sapiens_hsa04614	-0.1138371
103	Ether lipid metabolism_Homo sapiens_hsa00565	-0.1074871
104	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.1043592
105	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0804784
106	Insulin signaling pathway_Homo sapiens_hsa04910	-0.0754644
107	Amoebiasis_Homo sapiens_hsa05146	-0.0747289
108	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0138202
109	ECM-receptor interaction_Homo sapiens_hsa04512	-0.0055515

ANGPTL8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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