ANK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemoglobin metabolic process (GO:0020027)7.93307471
2erythrocyte maturation (GO:0043249)7.49728394
3protoporphyrinogen IX metabolic process (GO:0046501)6.37282119
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.04589047
5sarcomere organization (GO:0045214)5.83254595
6negative regulation of erythrocyte differentiation (GO:0045647)5.81976441
7plasma membrane repair (GO:0001778)5.76662999
8* erythrocyte development (GO:0048821)5.70144439
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.61297275
10actin-myosin filament sliding (GO:0033275)5.53487013
11muscle filament sliding (GO:0030049)5.53487013
12regulation of response to osmotic stress (GO:0047484)5.51987022
13sarcoplasmic reticulum calcium ion transport (GO:0070296)5.50878373
14protoporphyrinogen IX biosynthetic process (GO:0006782)5.50330018
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.47399703
16regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.26661776
17cardiac myofibril assembly (GO:0055003)5.24205413
18myofibril assembly (GO:0030239)5.20242837
19cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.18504709
20negative regulation of potassium ion transmembrane transport (GO:1901380)5.12050691
21cardiac muscle contraction (GO:0060048)5.10163687
22regulation of cell communication by electrical coupling (GO:0010649)5.07844045
23regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.02367795
24regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.91555145
25regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.85771272
26regulation of skeletal muscle contraction (GO:0014819)4.80440344
27* porphyrin-containing compound biosynthetic process (GO:0006779)4.77932808
28iron ion import (GO:0097286)4.61420726
29regulation of actin filament-based movement (GO:1903115)4.59143605
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.56255385
31striated muscle contraction (GO:0006941)4.51712646
32cell communication by electrical coupling (GO:0010644)4.46933327
33* myeloid cell development (GO:0061515)4.45765977
34actin-mediated cell contraction (GO:0070252)4.44174779
35sodium ion export (GO:0071436)4.39042028
36regulation of relaxation of muscle (GO:1901077)4.33913517
37* tetrapyrrole biosynthetic process (GO:0033014)4.32186901
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.29202037
39cell communication involved in cardiac conduction (GO:0086065)4.25336417
40regulation of membrane repolarization (GO:0060306)4.20140835
41positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.15770046
42* tetrapyrrole metabolic process (GO:0033013)4.15593618
43heme biosynthetic process (GO:0006783)4.10217259
44potassium ion import (GO:0010107)4.07407283
45neuronal action potential propagation (GO:0019227)4.05163523
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.03957031
47granulocyte differentiation (GO:0030851)4.00159710
48megakaryocyte development (GO:0035855)3.93710087
49tricarboxylic acid cycle (GO:0006099)3.93362712
50actomyosin structure organization (GO:0031032)3.92571404
51erythrocyte differentiation (GO:0030218)3.92372716
52regulation of calcium ion transmembrane transporter activity (GO:1901019)3.91510897
53regulation of calcium ion transmembrane transport (GO:1903169)3.91510897
54definitive hemopoiesis (GO:0060216)3.88806231
55regulation of striated muscle contraction (GO:0006942)3.79775161
56platelet formation (GO:0030220)3.79769968
57skeletal muscle contraction (GO:0003009)3.79124790
58cardiac muscle cell development (GO:0055013)3.67161842
59cerebellar Purkinje cell differentiation (GO:0021702)3.66848484
60response to lead ion (GO:0010288)3.66768133
61response to methylmercury (GO:0051597)3.66324258
62positive regulation of potassium ion transmembrane transport (GO:1901381)3.65918309
63cellular potassium ion homeostasis (GO:0030007)3.64393848
64membrane depolarization during action potential (GO:0086010)3.62017420
65regulation of erythrocyte differentiation (GO:0045646)3.60245465
66regulation of the force of heart contraction (GO:0002026)3.57793421
67regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.56848576
68ventricular cardiac muscle cell action potential (GO:0086005)3.56633059
69adult heart development (GO:0007512)3.52994633
70response to inactivity (GO:0014854)3.50657541
713-UTR-mediated mRNA stabilization (GO:0070935)3.48707781
72cardiac muscle hypertrophy (GO:0003300)3.47055286
73one-carbon compound transport (GO:0019755)3.46701073
74positive regulation of cation channel activity (GO:2001259)3.45021774
75cerebellar granule cell differentiation (GO:0021707)3.43088926
76carnitine shuttle (GO:0006853)3.42036122
77actin filament-based movement (GO:0030048)3.41666418
78regulation of cardiac muscle cell contraction (GO:0086004)3.41092514
79* porphyrin-containing compound metabolic process (GO:0006778)3.40830220
80response to insecticide (GO:0017085)3.38543958
81cardiac cell development (GO:0055006)3.38219701
82striated muscle hypertrophy (GO:0014897)3.37215420
83regulation of acyl-CoA biosynthetic process (GO:0050812)3.36581197
84response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.30598600
85positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.29452421
86relaxation of cardiac muscle (GO:0055119)3.29434993
87negative regulation of protein localization to cell surface (GO:2000009)3.27356721
88skeletal muscle fiber development (GO:0048741)3.26379457
89embryonic hemopoiesis (GO:0035162)3.25432831
90creatine metabolic process (GO:0006600)3.25242638
91regulation of RNA export from nucleus (GO:0046831)3.23316255
92synaptic vesicle maturation (GO:0016188)3.21389052
93skeletal muscle adaptation (GO:0043501)3.21184071
94regulation of sarcomere organization (GO:0060297)3.17928258
95locomotory exploration behavior (GO:0035641)3.17622565
96cytoskeletal anchoring at plasma membrane (GO:0007016)3.15256855
97regulation of cardiac muscle contraction (GO:0055117)3.15095453
98regulation of cation channel activity (GO:2001257)3.13684096
99cellular response to dexamethasone stimulus (GO:0071549)3.12847466
100glycine transport (GO:0015816)3.12125445
101activation of protein kinase A activity (GO:0034199)3.11481152
102response to muscle activity (GO:0014850)3.07368555
103cardiac muscle tissue morphogenesis (GO:0055008)3.07206783
104response to arsenic-containing substance (GO:0046685)3.06349689
105cardiac muscle cell action potential involved in contraction (GO:0086002)3.05908682
106muscle contraction (GO:0006936)3.04500420
107positive regulation of myotube differentiation (GO:0010831)3.03398915
108negative regulation of potassium ion transport (GO:0043267)3.03069183
109regulation of cofactor metabolic process (GO:0051193)3.02665787
110regulation of coenzyme metabolic process (GO:0051196)3.02665787
111cardiac muscle cell action potential (GO:0086001)3.01988803
112cellular response to thyroid hormone stimulus (GO:0097067)3.01408463
113positive regulation of granulocyte differentiation (GO:0030854)3.00558807
114gas transport (GO:0015669)2.99097247
115bicarbonate transport (GO:0015701)2.98322327
116actin filament capping (GO:0051693)2.97253186
117cardiac conduction (GO:0061337)2.96999766
118regulation of synapse structural plasticity (GO:0051823)2.96458271
119positive regulation of erythrocyte differentiation (GO:0045648)2.94745032
120positive regulation of ion transmembrane transporter activity (GO:0032414)2.94329695
121regulation of platelet aggregation (GO:0090330)2.93784064
122positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.92465886
123myotube cell development (GO:0014904)2.91917397
124muscle system process (GO:0003012)2.91823486
125carnitine transmembrane transport (GO:1902603)2.90825786
126muscle hypertrophy (GO:0014896)2.88801503
127positive regulation of potassium ion transport (GO:0043268)2.88627672
128regulation of potassium ion transmembrane transporter activity (GO:1901016)2.87650553
129regulation of heart rate (GO:0002027)2.86806634
130NADH metabolic process (GO:0006734)2.86303729
131neuromuscular process controlling posture (GO:0050884)2.85385917
132regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84991679
133response to dexamethasone (GO:0071548)2.84168771
134heme metabolic process (GO:0042168)2.83807322
135skeletal muscle tissue regeneration (GO:0043403)2.81247077
136N-terminal protein amino acid acetylation (GO:0006474)2.78642723
137negative regulation of necroptotic process (GO:0060546)2.76475988
138regulation of nucleobase-containing compound transport (GO:0032239)2.76318993
139striated muscle adaptation (GO:0014888)2.76289793
140cellular response to arsenic-containing substance (GO:0071243)2.75214754
141positive regulation of gluconeogenesis (GO:0045722)2.74780703
142pigment biosynthetic process (GO:0046148)2.74419201
143negative regulation of actin filament depolymerization (GO:0030835)2.73687811
144regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.70089679
145negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.66922642
1462-oxoglutarate metabolic process (GO:0006103)2.66593709
147glycogen biosynthetic process (GO:0005978)2.65307001
148glucan biosynthetic process (GO:0009250)2.65307001
149glycogen catabolic process (GO:0005980)2.64075153
150intracellular estrogen receptor signaling pathway (GO:0030520)2.62774648
151negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57132627
152negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.55187465
153negative regulation of calcium ion transmembrane transport (GO:1903170)2.55187465
154glucan catabolic process (GO:0009251)2.54346097
155oxygen transport (GO:0015671)10.5690988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.35881410
2EZH2_22144423_ChIP-Seq_EOC_Human4.29429871
3GATA1_22025678_ChIP-Seq_K562_Human3.85660689
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49438120
5* GATA1_19941826_ChIP-Seq_K562_Human3.30566764
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.22232136
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.92572305
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.89794906
9* GATA1_19941827_ChIP-Seq_MEL_Mouse2.69424973
10DROSHA_22980978_ChIP-Seq_HELA_Human2.54195820
11ZNF263_19887448_ChIP-Seq_K562_Human2.53362726
12NCOR1_26117541_ChIP-Seq_K562_Human2.45551766
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44630912
14* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.39182761
15TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.29605385
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26866956
17MYC_22102868_ChIP-Seq_BL_Human2.26848809
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.25480690
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17084541
20* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.16180415
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08742770
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.05982568
23KDM2B_26808549_Chip-Seq_K562_Human2.03798343
24TBX20_22328084_ChIP-Seq_HEART_Mouse2.01334566
25TBX20_22080862_ChIP-Seq_HEART_Mouse2.01334566
26* EP300_21415370_ChIP-Seq_HL-1_Mouse1.95856992
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.93814366
28* GATA2_19941826_ChIP-Seq_K562_Human1.90561734
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88391191
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.87313022
31* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85929338
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83335730
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83335730
34KDM2B_26808549_Chip-Seq_DND41_Human1.81601588
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.80656671
36VDR_21846776_ChIP-Seq_THP-1_Human1.78963277
37* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78544986
38BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.77203391
39GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67793360
40MAF_26560356_Chip-Seq_TH1_Human1.67306532
41* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67086729
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65337010
43* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62853659
44* EZH2_27294783_Chip-Seq_ESCs_Mouse1.62722281
45* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60563222
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58367374
47* REST_18959480_ChIP-ChIP_MESCs_Mouse1.56813765
48* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56253899
49* REST_21632747_ChIP-Seq_MESCs_Mouse1.54963884
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51246679
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49731279
52* SPI1_23127762_ChIP-Seq_K562_Human1.49158931
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47548173
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46373593
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.42247353
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40884817
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40431659
58LXR_22292898_ChIP-Seq_THP-1_Human1.37771234
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37637408
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37396800
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37098490
62* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36852010
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34243913
64CTCF_21964334_ChIP-Seq_BJAB-B_Human1.31812692
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31675369
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31006387
67CTCF_27219007_Chip-Seq_Bcells_Human1.29987955
68SCL_19346495_ChIP-Seq_HPC-7_Human1.26828362
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26798408
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26622345
71ZNF274_21170338_ChIP-Seq_K562_Hela1.25480680
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24544572
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23556866
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23039424
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22963067
76* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21971645
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21948493
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21326571
79P68_20966046_ChIP-Seq_HELA_Human1.21248325
80UTX_26944678_Chip-Seq_JUKART_Human1.19609438
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19018748
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.18657377
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.18224934
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.18194208
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.17438613
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16343854
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15176618
88VDR_24763502_ChIP-Seq_THP-1_Human1.14851593
89AR_21572438_ChIP-Seq_LNCaP_Human1.14763720
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13352755
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.12722761
92GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.12652258
93* RNF2_27304074_Chip-Seq_ESCs_Mouse1.12571135
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09930030
95ETS1_22383799_ChIP-Seq_G1ME_Mouse1.09565362
96TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09464454
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07281999
98GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07071646
99CTCF_21964334_Chip-Seq_Bcells_Human1.06667661
100CREB1_26743006_Chip-Seq_LNCaP_Human1.06502230
101EGR1_19374776_ChIP-ChIP_THP-1_Human1.06438130
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06075811
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.05932527
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04434481
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04381734
106* AR_19668381_ChIP-Seq_PC3_Human1.03951755
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02546057
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02523158
109OCT4_19829295_ChIP-Seq_ESCs_Human1.01996773
110TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01391327
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01052670
112SOX2_21211035_ChIP-Seq_LN229_Gbm1.00174648
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99318059
114CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99067915
115GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98982329
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98611782
117MAF_26560356_Chip-Seq_TH2_Human0.98531817
118FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97691246
119MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97436247
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96340488
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96282545
122SMC4_20622854_ChIP-Seq_HELA_Human0.94838555
123TCF7_22412390_ChIP-Seq_EML_Mouse0.94430637
124TET1_21490601_ChIP-Seq_MESCs_Mouse0.92471676
125SA1_27219007_Chip-Seq_ERYTHROID_Human0.92408648
126KLF4_19829295_ChIP-Seq_ESCs_Human0.92134378
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91250971
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.90408740
129TP63_22573176_ChIP-Seq_HFKS_Human0.89597388
130CIITA_25753668_ChIP-Seq_RAJI_Human0.88886733
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87926372
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87919078
133* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87434740
134RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87344523
135* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86288470
136NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85805919
137SPI1_20517297_ChIP-Seq_HL60_Human0.85287377
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84407927
139CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84184029
140* BCOR_27268052_Chip-Seq_Bcells_Human0.83797478
141SA1_27219007_Chip-Seq_Bcells_Human0.82721430
142P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82268078
143FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81658287
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81148378
145NANOG_21062744_ChIP-ChIP_HESCs_Human0.80141024
146PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77345756
147* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77036238
148TFEB_21752829_ChIP-Seq_HELA_Human0.75418993
149SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73919218
150ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.73250565
151WT1_19549856_ChIP-ChIP_CCG9911_Human0.72197250
152YY1_22570637_ChIP-Seq_MALME-3M_Human0.70327700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.21795099
2MP0002837_dystrophic_cardiac_calcinosis5.15886795
3MP0000751_myopathy4.69813376
4MP0004145_abnormal_muscle_electrophysio4.23049838
5MP0000749_muscle_degeneration4.07207251
6MP0004215_abnormal_myocardial_fiber3.88264814
7MP0004084_abnormal_cardiac_muscle3.81068583
8MP0005451_abnormal_body_composition3.68924079
9MP0004036_abnormal_muscle_relaxation3.47414429
10* MP0003656_abnormal_erythrocyte_physiolo3.22737597
11MP0004859_abnormal_synaptic_plasticity2.91403131
12MP0004087_abnormal_muscle_fiber2.70573934
13MP0005330_cardiomyopathy2.64333532
14MP0000747_muscle_weakness2.63203680
15MP0001545_abnormal_hematopoietic_system2.61924403
16MP0005397_hematopoietic_system_phenotyp2.61924403
17MP0002106_abnormal_muscle_physiology2.51870346
18MP0008775_abnormal_heart_ventricle2.44612549
19MP0005620_abnormal_muscle_contractility2.40463073
20MP0002972_abnormal_cardiac_muscle2.33460837
21MP0002269_muscular_atrophy2.33446437
22MP0003137_abnormal_impulse_conducting2.32793834
23MP0004130_abnormal_muscle_cell2.32292971
24MP0009046_muscle_twitch2.27807641
25MP0000759_abnormal_skeletal_muscle2.24178982
26MP0004484_altered_response_of2.22082753
27MP0005369_muscle_phenotype2.08005153
28MP0000750_abnormal_muscle_regeneration2.07012221
29MP0008569_lethality_at_weaning1.97257693
30* MP0004147_increased_porphyrin_level1.82299661
31MP0004085_abnormal_heartbeat1.81198886
32MP0004233_abnormal_muscle_weight1.80862871
33MP0003635_abnormal_synaptic_transmissio1.78317619
34MP0005385_cardiovascular_system_phenoty1.73813451
35MP0001544_abnormal_cardiovascular_syste1.73813451
36MP0010630_abnormal_cardiac_muscle1.71102269
37MP0004270_analgesia1.69571471
38MP0008260_abnormal_autophagy1.65322995
39MP0008995_early_reproductive_senescence1.64463573
40MP0002822_catalepsy1.63038379
41MP0009278_abnormal_bone_marrow1.59586331
42MP0004510_myositis1.57321569
43MP0006138_congestive_heart_failure1.54345315
44MP0006036_abnormal_mitochondrial_physio1.53700757
45MP0002332_abnormal_exercise_endurance1.51686391
46MP0002735_abnormal_chemical_nociception1.51614050
47MP0001968_abnormal_touch/_nociception1.49316642
48MP0002272_abnormal_nervous_system1.42958884
49MP0002734_abnormal_mechanical_nocicepti1.40213990
50MP0005464_abnormal_platelet_physiology1.35840662
51MP0002064_seizures1.35662013
52MP0003303_peritoneal_inflammation1.33845387
53MP0009745_abnormal_behavioral_response1.33390981
54MP0002736_abnormal_nociception_after1.32502490
55MP0002067_abnormal_sensory_capabilities1.29523791
56MP0001440_abnormal_grooming_behavior1.21796123
57MP0003221_abnormal_cardiomyocyte_apopto1.18700029
58MP0002909_abnormal_adrenal_gland1.17099367
59MP0001529_abnormal_vocalization1.15051802
60* MP0005636_abnormal_mineral_homeostasis1.12768755
61MP0004808_abnormal_hematopoietic_stem1.10588769
62MP0002063_abnormal_learning/memory/cond1.08996406
63MP0005423_abnormal_somatic_nervous1.06851524
64MP0001661_extended_life_span1.04153541
65MP0004924_abnormal_behavior1.02204236
66MP0005386_behavior/neurological_phenoty1.02204236
67MP0003828_pulmonary_edema1.02155073
68MP0003111_abnormal_nucleus_morphology1.00732747
69MP0006035_abnormal_mitochondrial_morpho0.99003324
70MP0003880_abnormal_central_pattern0.98680501
71MP0003329_amyloid_beta_deposits0.96844269
72MP0004142_abnormal_muscle_tone0.95480236
73MP0002108_abnormal_muscle_morphology0.95350809
74MP0002733_abnormal_thermal_nociception0.95310642
75MP0001970_abnormal_pain_threshold0.94497490
76MP0005666_abnormal_adipose_tissue0.93030726
77MP0004043_abnormal_pH_regulation0.88652018
78MP0002396_abnormal_hematopoietic_system0.83141404
79MP0002572_abnormal_emotion/affect_behav0.83027136
80MP0003633_abnormal_nervous_system0.81188432
81MP0004858_abnormal_nervous_system0.80652018
82* MP0000266_abnormal_heart_morphology0.80583574
83* MP0002066_abnormal_motor_capabilities/c0.79630393
84MP0008961_abnormal_basal_metabolism0.79528099
85MP0004811_abnormal_neuron_physiology0.79328034
86MP0000013_abnormal_adipose_tissue0.78549440
87MP0005375_adipose_tissue_phenotype0.78494411
88MP0002127_abnormal_cardiovascular_syste0.78267434
89MP0002184_abnormal_innervation0.77819657
90* MP0002398_abnormal_bone_marrow0.76898851
91MP0004185_abnormal_adipocyte_glucose0.76368966
92MP0003186_abnormal_redox_activity0.75368303
93MP0000003_abnormal_adipose_tissue0.74992096
94MP0000733_abnormal_muscle_development0.74548452
95MP0003191_abnormal_cellular_cholesterol0.74203009
96MP0001486_abnormal_startle_reflex0.72522903
97MP0000689_abnormal_spleen_morphology0.72114671
98MP0005266_abnormal_metabolism0.69816073
99MP0003631_nervous_system_phenotype0.68727015
100MP0009931_abnormal_skin_appearance0.68594513
101MP0005076_abnormal_cell_differentiation0.68298110
102MP0001299_abnormal_eye_distance/0.68079975
103MP0002971_abnormal_brown_adipose0.67281916
104* MP0002722_abnormal_immune_system0.66612412
105MP0008872_abnormal_physiological_respon0.66431209
106MP0000955_abnormal_spinal_cord0.66429703
107MP0006276_abnormal_autonomic_nervous0.66019539
108MP0003950_abnormal_plasma_membrane0.65800621
109MP0002234_abnormal_pharynx_morphology0.65112872
110MP0001501_abnormal_sleep_pattern0.64792199
111MP0003879_abnormal_hair_cell0.64642894
112MP0009780_abnormal_chondrocyte_physiolo0.64128792
113MP0005623_abnormal_meninges_morphology0.63106746
114MP0002132_abnormal_respiratory_system0.61447086
115MP0005535_abnormal_body_temperature0.61172362
116MP0003172_abnormal_lysosome_physiology0.60927937
117MP0008770_decreased_survivor_rate0.60792266
118MP0002009_preneoplasia0.59820208
119MP0003045_fibrosis0.59214868
120MP0005187_abnormal_penis_morphology0.56873121
121MP0009697_abnormal_copulation0.56198328
122MP0000372_irregular_coat_pigmentation0.56097800
123MP0003705_abnormal_hypodermis_morpholog0.55659877
124MP0002877_abnormal_melanocyte_morpholog0.55479219
125MP0008874_decreased_physiological_sensi0.54829381
126MP0000920_abnormal_myelination0.53346511
127MP0005165_increased_susceptibility_to0.53258085
128MP0000343_altered_response_to0.53085715
129MP0000313_abnormal_cell_death0.50688182
130MP0002078_abnormal_glucose_homeostasis0.50305857
131MP0008057_abnormal_DNA_replication0.49972578
132MP0000609_abnormal_liver_physiology0.43939342
133* MP0002429_abnormal_blood_cell0.43568052
134MP0000015_abnormal_ear_pigmentation0.43084437
135MP0001784_abnormal_fluid_regulation0.42515810
136MP0005452_abnormal_adipose_tissue0.41150501
137* MP0000703_abnormal_thymus_morphology0.40442956
138MP0005645_abnormal_hypothalamus_physiol0.39247607
139MP0005167_abnormal_blood-brain_barrier0.39226931

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.32099021
2Exercise-induced muscle cramps (HP:0003710)6.00053557
3Sudden death (HP:0001699)5.92805190
4Calf muscle hypertrophy (HP:0008981)5.65842618
5Muscle hypertrophy of the lower extremities (HP:0008968)5.62911090
6Muscle fiber splitting (HP:0003555)4.70495083
7Hyporeflexia of lower limbs (HP:0002600)4.53589712
8Abnormality of the calf musculature (HP:0001430)4.46589737
9Difficulty running (HP:0009046)4.34643275
10* Poikilocytosis (HP:0004447)4.32772387
11Myoglobinuria (HP:0002913)4.31794105
12Myotonia (HP:0002486)4.29386293
13Abnormal hemoglobin (HP:0011902)4.27041226
14Bundle branch block (HP:0011710)4.26208084
15Ventricular tachycardia (HP:0004756)4.25478483
16Abnormality of the left ventricular outflow tract (HP:0011103)4.11373123
17Subaortic stenosis (HP:0001682)4.11373123
18Atrial fibrillation (HP:0005110)4.11360031
19Microcytic anemia (HP:0001935)3.96812540
20EMG: myopathic abnormalities (HP:0003458)3.94847247
21Abnormality of the heme biosynthetic pathway (HP:0010472)3.88962644
22Primary atrial arrhythmia (HP:0001692)3.84597620
23Muscle fiber inclusion bodies (HP:0100299)3.78042454
24Centrally nucleated skeletal muscle fibers (HP:0003687)3.73416625
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.69416553
26Supraventricular tachycardia (HP:0004755)3.69075058
27Ventricular fibrillation (HP:0001663)3.65674469
28Supraventricular arrhythmia (HP:0005115)3.59516471
29Dysmetric saccades (HP:0000641)3.52097022
30Increased connective tissue (HP:0009025)3.47199414
31Prolonged QT interval (HP:0001657)3.36519143
32Muscle stiffness (HP:0003552)3.35360931
33Lipoatrophy (HP:0100578)3.29095257
34Diaphragmatic weakness (HP:0009113)3.24892505
35Type 1 muscle fiber predominance (HP:0003803)3.24455167
36Syncope (HP:0001279)3.24376900
37Hypochromic anemia (HP:0001931)3.14143585
38* Abnormality of reticulocytes (HP:0004312)3.12671567
39Heart block (HP:0012722)3.11052990
40Nemaline bodies (HP:0003798)3.07621952
41Asymmetric septal hypertrophy (HP:0001670)3.01824428
42Acanthocytosis (HP:0001927)3.01474670
43Ventricular arrhythmia (HP:0004308)3.00943015
44Action tremor (HP:0002345)2.97840574
45Abnormal atrioventricular conduction (HP:0005150)2.96589298
46Calcaneovalgus deformity (HP:0001848)2.96060602
47Rhabdomyolysis (HP:0003201)2.93352739
48Ileus (HP:0002595)2.92356803
49Visual hallucinations (HP:0002367)2.91790251
50* Cholelithiasis (HP:0001081)2.91187668
51Difficulty climbing stairs (HP:0003551)2.91028852
52* Reticulocytosis (HP:0001923)2.88365865
53Increased variability in muscle fiber diameter (HP:0003557)2.87407823
54Distal arthrogryposis (HP:0005684)2.86635849
55Dilated cardiomyopathy (HP:0001644)2.80641311
56Toxemia of pregnancy (HP:0100603)2.80433676
57Abnormality of skeletal muscle fiber size (HP:0012084)2.72561147
58Right ventricular cardiomyopathy (HP:0011663)2.70355608
59Atrioventricular block (HP:0001678)2.65162917
60Abnormal EKG (HP:0003115)2.63619519
61Palpitations (HP:0001962)2.60068667
62Paralysis (HP:0003470)2.58701184
63Deformed tarsal bones (HP:0008119)2.57444966
64Insomnia (HP:0100785)2.56949643
65Myopathic facies (HP:0002058)2.50840982
66* Abnormal gallbladder morphology (HP:0012437)2.50658931
67Focal motor seizures (HP:0011153)2.50436302
68Focal seizures (HP:0007359)2.48813423
69* Hyperbilirubinemia (HP:0002904)2.47106949
70* Abnormality of the gallbladder (HP:0005264)2.46950690
71Lower limb amyotrophy (HP:0007210)2.44278480
72EMG: neuropathic changes (HP:0003445)2.43104634
73Prolonged bleeding time (HP:0003010)2.40612237
74Areflexia of lower limbs (HP:0002522)2.37482340
75Progressive cerebellar ataxia (HP:0002073)2.35757936
76Malignant hyperthermia (HP:0002047)2.34411274
77Round ear (HP:0100830)2.32711816
78Absent phalangeal crease (HP:0006109)2.31318742
79Depression (HP:0000716)2.29272759
80Neck muscle weakness (HP:0000467)2.28784776
81Limb-girdle muscle atrophy (HP:0003797)2.26827348
82Long clavicles (HP:0000890)2.24995023
83Dysdiadochokinesis (HP:0002075)2.23656346
84Pheochromocytoma (HP:0002666)2.23224739
85Hyperkalemia (HP:0002153)2.23110519
86Foot dorsiflexor weakness (HP:0009027)2.19414283
87Febrile seizures (HP:0002373)2.17037398
88Abnormality of the foot musculature (HP:0001436)2.16768362
89Myokymia (HP:0002411)2.16197911
90Distal lower limb muscle weakness (HP:0009053)2.15961037
91Impaired social interactions (HP:0000735)2.15545438
92Abnormal social behavior (HP:0012433)2.15545438
93Poor eye contact (HP:0000817)2.15545265
94Abnormality of iron homeostasis (HP:0011031)2.14140692
95Left ventricular hypertrophy (HP:0001712)2.13056572
96Distal lower limb amyotrophy (HP:0008944)2.12894357
97Abnormality of the fingertips (HP:0001211)2.12024341
98Abnormality of the calcaneus (HP:0008364)2.11211949
99Generalized tonic-clonic seizures (HP:0002069)2.09169856
100Gaze-evoked nystagmus (HP:0000640)2.04173714
101Generalized muscle weakness (HP:0003324)2.03729654
102Anxiety (HP:0000739)2.01075109
103Fetal akinesia sequence (HP:0001989)2.01004854
104Hypochromic microcytic anemia (HP:0004840)1.95406721
105Polycythemia (HP:0001901)1.93295148
106Postural instability (HP:0002172)1.92555872
107Neuroendocrine neoplasm (HP:0100634)1.92427448
108Cerebral palsy (HP:0100021)1.91449572
109Proximal amyotrophy (HP:0007126)1.89178536
110Mildly elevated creatine phosphokinase (HP:0008180)1.88336924
111Abnormality of transition element cation homeostasis (HP:0011030)1.88152581
112Frequent falls (HP:0002359)1.87039838
113Atonic seizures (HP:0010819)1.85956256
114Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84797546
115Weak cry (HP:0001612)1.84314618
116Ulnar deviation of the wrist (HP:0003049)1.83821011
117Abnormal gallbladder physiology (HP:0012438)1.82993386
118Cholecystitis (HP:0001082)1.82993386
119Abnormal finger flexion creases (HP:0006143)1.82135580
120Progressive muscle weakness (HP:0003323)1.81421968
121Broad-based gait (HP:0002136)1.80672825
122Rimmed vacuoles (HP:0003805)1.80251608
123Facial diplegia (HP:0001349)1.78245428
124Truncal ataxia (HP:0002078)1.78177143
125Muscular dystrophy (HP:0003560)1.76548557
126Gowers sign (HP:0003391)1.76205826
127Rapidly progressive (HP:0003678)1.75587642
128Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75045197
129Slender build (HP:0001533)1.74702823
130Increased serum ferritin (HP:0003281)1.73168698
131Hypertensive crisis (HP:0100735)1.69630090
132Fatigue (HP:0012378)1.69097248
133Bowel incontinence (HP:0002607)1.64017533
134Hyponatremia (HP:0002902)1.63677483
135Bulbar palsy (HP:0001283)1.61906697
136Pallor (HP:0000980)1.58273057
137Osteomalacia (HP:0002749)1.57166792
138Abnormal large intestine physiology (HP:0012700)1.54585989
139Scapular winging (HP:0003691)1.54325879
140Abnormality of sodium homeostasis (HP:0010931)1.50462220
141Childhood onset (HP:0011463)1.48242734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.74886753
2PHKG24.30264968
3PHKG14.30264968
4PRPF4B3.94052753
5OBSCN3.46599126
6LMTK23.06785137
7TAOK22.53618394
8TRIB32.43467180
9PINK12.38779797
10NEK12.18232805
11DMPK2.08820754
12RIPK12.07869373
13WNK12.01087991
14PDK31.91069286
15PDK41.91069286
16PIK3CG1.89535483
17RIPK41.72709646
18NTRK31.68969926
19PKN21.67847344
20MUSK1.62832303
21CAMKK21.57746931
22MAP3K41.56239273
23MAP2K41.53793473
24STK381.47066944
25MYLK1.38498597
26PIK3CA1.35736146
27CDC42BPA1.34460246
28CAMKK11.34276300
29PAK61.31954141
30STK41.30073187
31PIM11.30013209
32PRKAA11.26822383
33MAP3K91.22116681
34MAP3K71.21570476
35MAPK121.20151313
36TAOK11.19864993
37CLK11.16739909
38MAP2K11.16423142
39SGK31.15899473
40MAP3K31.13022525
41MAP3K11.08932843
42MAP2K31.07988455
43MINK11.07962347
44DAPK21.07123812
45CCNB11.04015691
46CDK121.02795627
47MAP3K101.01983178
48EIF2AK10.99361486
49MAPKAPK30.97250500
50SCYL20.96992518
51RET0.87956684
52DYRK30.87305326
53PDK20.87227709
54ZAK0.87127157
55PRKCH0.86627994
56MARK30.85531518
57SYK0.85042650
58KSR20.84979551
59GRK60.84644634
60CAMK40.84208924
61SGK20.84157743
62PRKD10.83826911
63GRK50.83671112
64CAMK2D0.83230901
65HIPK20.82487475
66KSR10.82318053
67STK240.81168086
68BCKDK0.79964901
69SGK10.79533578
70GRK70.79466122
71CAMK10.79383271
72SGK2230.77808374
73SGK4940.77808374
74ROCK10.77319156
75PAK30.76720500
76DYRK1B0.76508530
77RAF10.74387110
78PRKAA20.74324363
79RPS6KA50.73692680
80PDPK10.70881050
81TRPM70.70707921
82STK110.70130454
83RPS6KC10.69797587
84RPS6KL10.69797587
85PDK10.69374526
86NME10.68615500
87ROCK20.68388615
88MARK20.67747217
89CAMK1G0.67346223
90EEF2K0.66359740
91CAMK1D0.65859009
92PKN10.65254671
93MAP3K80.63937846
94PRKD30.63679470
95RPS6KA30.63040544
96ALK0.62646231
97UHMK10.62538641
98CDK50.62419956
99CAMK2G0.61397380
100MAP2K70.59732628
101ICK0.58943801
102MARK10.58438681
103PRKACB0.57978349
104TIE10.56388500
105BRAF0.56224703
106RPS6KA60.55776898
107NTRK10.55386299
108CAMK2A0.54953840
109NTRK20.52738758
110PRKACG0.51878793
111MAPK110.51411338
112MAP3K50.50793382
113PTK2B0.50689457
114BRSK10.49479258
115MAP3K130.49085798
116MAP3K60.48489813
117MAPKAPK50.47804630
118DAPK30.47505424
119CDK190.47052713
120MTOR0.45229649
121AKT20.45166757
122JAK20.44878585
123RPS6KA20.43622868
124PRKACA0.42934907
125PDGFRA0.42233855
126PRKCG0.41736741
127WNK40.41410265
128MAP3K110.40998204
129EPHB10.40371075
130MAPK40.40360944
131SIK20.40016020
132BMX0.39373210
133PRKG10.39244415
134ZAP700.39094318
135MAPK100.37889955
136TNK20.35581628
137AKT10.32764732
138SIK10.32171787
139BTK0.30858046
140MAP2K60.30124945
141DYRK1A0.29850809
142RPS6KB10.28960610
143MAPK30.27004697
144RPS6KA10.26700772
145IKBKE0.26559023
146SMG10.22079806
147RPS6KB20.20844035
148CDC70.20733789

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.04870838
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.53302666
3Cardiac muscle contraction_Homo sapiens_hsa042603.39605136
4Dilated cardiomyopathy_Homo sapiens_hsa054142.96165189
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.78256879
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.47739916
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.33563066
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.16025744
9Malaria_Homo sapiens_hsa051442.04850388
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.97860028
11Nicotine addiction_Homo sapiens_hsa050331.87782344
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82234707
13Long-term potentiation_Homo sapiens_hsa047201.73933995
14Circadian entrainment_Homo sapiens_hsa047131.73923660
15Gastric acid secretion_Homo sapiens_hsa049711.65929720
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64310009
17Oxytocin signaling pathway_Homo sapiens_hsa049211.59447340
18Salivary secretion_Homo sapiens_hsa049701.58325403
19Synaptic vesicle cycle_Homo sapiens_hsa047211.55984506
20Calcium signaling pathway_Homo sapiens_hsa040201.55756335
21Pentose phosphate pathway_Homo sapiens_hsa000301.54195964
22GABAergic synapse_Homo sapiens_hsa047271.52754423
23Glutamatergic synapse_Homo sapiens_hsa047241.52620146
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.52233076
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52204592
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51748602
27Type II diabetes mellitus_Homo sapiens_hsa049301.50240279
28Parkinsons disease_Homo sapiens_hsa050121.47715896
29Chronic myeloid leukemia_Homo sapiens_hsa052201.45837739
30Fructose and mannose metabolism_Homo sapiens_hsa000511.43295546
31Insulin secretion_Homo sapiens_hsa049111.42935810
32Acute myeloid leukemia_Homo sapiens_hsa052211.40810102
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.35379844
34Olfactory transduction_Homo sapiens_hsa047401.33633744
35Propanoate metabolism_Homo sapiens_hsa006401.32340473
36Regulation of autophagy_Homo sapiens_hsa041401.32319706
37Alzheimers disease_Homo sapiens_hsa050101.31624533
38Morphine addiction_Homo sapiens_hsa050321.31618284
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31207830
40FoxO signaling pathway_Homo sapiens_hsa040681.23951007
41Pancreatic cancer_Homo sapiens_hsa052121.23528847
42Taste transduction_Homo sapiens_hsa047421.23384010
43Renal cell carcinoma_Homo sapiens_hsa052111.22331340
44Carbon metabolism_Homo sapiens_hsa012001.22226578
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19606062
46Oxidative phosphorylation_Homo sapiens_hsa001901.18378948
47Long-term depression_Homo sapiens_hsa047301.16195309
48Glucagon signaling pathway_Homo sapiens_hsa049221.13031077
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12955191
50Systemic lupus erythematosus_Homo sapiens_hsa053221.12811887
51Insulin signaling pathway_Homo sapiens_hsa049101.12126255
52Renin secretion_Homo sapiens_hsa049241.08689205
53Cholinergic synapse_Homo sapiens_hsa047251.08651048
54cAMP signaling pathway_Homo sapiens_hsa040241.04204867
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03203107
56Amphetamine addiction_Homo sapiens_hsa050311.02635905
57GnRH signaling pathway_Homo sapiens_hsa049121.02311799
58Dopaminergic synapse_Homo sapiens_hsa047281.01512969
59Adipocytokine signaling pathway_Homo sapiens_hsa049201.00171517
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98236093
61Fatty acid degradation_Homo sapiens_hsa000710.96564052
62Alcoholism_Homo sapiens_hsa050340.96497105
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96456347
64B cell receptor signaling pathway_Homo sapiens_hsa046620.96456116
65Insulin resistance_Homo sapiens_hsa049310.96402704
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96041417
67Endometrial cancer_Homo sapiens_hsa052130.95538395
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.95134754
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94633122
70Dorso-ventral axis formation_Homo sapiens_hsa043200.94049474
71Gap junction_Homo sapiens_hsa045400.93985611
72Pancreatic secretion_Homo sapiens_hsa049720.90259634
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89875719
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88896100
75AMPK signaling pathway_Homo sapiens_hsa041520.88627876
76Huntingtons disease_Homo sapiens_hsa050160.83047585
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.81750795
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81168768
79African trypanosomiasis_Homo sapiens_hsa051430.80196971
80Circadian rhythm_Homo sapiens_hsa047100.79815139
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78913989
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75892460
83Estrogen signaling pathway_Homo sapiens_hsa049150.75648227
84Pyruvate metabolism_Homo sapiens_hsa006200.75286311
85Arginine and proline metabolism_Homo sapiens_hsa003300.74889321
86Fatty acid metabolism_Homo sapiens_hsa012120.74311520
87Thyroid cancer_Homo sapiens_hsa052160.73707931
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70506079
89Cell cycle_Homo sapiens_hsa041100.69929309
90Prolactin signaling pathway_Homo sapiens_hsa049170.68383102
91Nitrogen metabolism_Homo sapiens_hsa009100.68234641
92ErbB signaling pathway_Homo sapiens_hsa040120.67666180
93mTOR signaling pathway_Homo sapiens_hsa041500.67596700
94Glioma_Homo sapiens_hsa052140.67463028
95Viral myocarditis_Homo sapiens_hsa054160.67246417
96Bile secretion_Homo sapiens_hsa049760.67014250
97Bladder cancer_Homo sapiens_hsa052190.66157478
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.63589813
99Viral carcinogenesis_Homo sapiens_hsa052030.61648187
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61631340
101Choline metabolism in cancer_Homo sapiens_hsa052310.58520719
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.58163525
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58114612
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57655593
105Vitamin B6 metabolism_Homo sapiens_hsa007500.56929192
106MAPK signaling pathway_Homo sapiens_hsa040100.56851918
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.56757015
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56172206
109Oocyte meiosis_Homo sapiens_hsa041140.54007453
110Collecting duct acid secretion_Homo sapiens_hsa049660.53937980
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51962395
112Non-small cell lung cancer_Homo sapiens_hsa052230.50826357
113HIF-1 signaling pathway_Homo sapiens_hsa040660.49643631
114Inositol phosphate metabolism_Homo sapiens_hsa005620.49507201
115Arginine biosynthesis_Homo sapiens_hsa002200.49469102
116Biosynthesis of amino acids_Homo sapiens_hsa012300.49095084
117Lysine degradation_Homo sapiens_hsa003100.48905673
118VEGF signaling pathway_Homo sapiens_hsa043700.48612375
119Platelet activation_Homo sapiens_hsa046110.47561970
120Serotonergic synapse_Homo sapiens_hsa047260.47530600
121ABC transporters_Homo sapiens_hsa020100.47061021
122Thyroid hormone synthesis_Homo sapiens_hsa049180.46068265
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45856680
124Apoptosis_Homo sapiens_hsa042100.45123229
125Hepatitis B_Homo sapiens_hsa051610.44284075
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44023778
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43645289
128Prostate cancer_Homo sapiens_hsa052150.43507210
129Focal adhesion_Homo sapiens_hsa045100.43374007
130Butanoate metabolism_Homo sapiens_hsa006500.42976174
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.41599774
132Tight junction_Homo sapiens_hsa045300.41389572
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39780143
134Hematopoietic cell lineage_Homo sapiens_hsa046400.38997151

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