ANKAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.86707404
2cell wall macromolecule metabolic process (GO:0044036)9.86707404
3epithelial cilium movement (GO:0003351)9.78418962
4reproduction (GO:0000003)9.64444262
5male meiosis (GO:0007140)9.57582040
6acrosome reaction (GO:0007340)9.20660696
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.07381130
8cilium movement (GO:0003341)8.82636224
9motile cilium assembly (GO:0044458)8.63753571
10spermatid development (GO:0007286)8.43461239
11synaptonemal complex organization (GO:0070193)8.37106361
12synaptonemal complex assembly (GO:0007130)8.27680794
13single fertilization (GO:0007338)7.74353231
14regulation of cilium movement (GO:0003352)7.21711637
15sperm capacitation (GO:0048240)6.80769183
16DNA methylation involved in gamete generation (GO:0043046)6.76357958
17fertilization (GO:0009566)6.52655199
18chromosome organization involved in meiosis (GO:0070192)5.92273851
19male meiosis I (GO:0007141)5.77992167
20ventricular system development (GO:0021591)5.64391283
21spermatogenesis (GO:0007283)5.53123806
22male gamete generation (GO:0048232)5.51267633
23meiotic nuclear division (GO:0007126)5.29610984
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.19615676
25monoubiquitinated protein deubiquitination (GO:0035520)5.13866608
26gamete generation (GO:0007276)5.07461128
27cell recognition (GO:0008037)4.99584092
28germ cell development (GO:0007281)4.97570578
29tyrosine phosphorylation of STAT protein (GO:0007260)4.90499001
30microtubule depolymerization (GO:0007019)4.88785621
31seminiferous tubule development (GO:0072520)4.85654766
32negative regulation of inclusion body assembly (GO:0090084)4.81126295
33microtubule severing (GO:0051013)4.79476836
34meiosis I (GO:0007127)4.69269521
35protein localization to cilium (GO:0061512)4.62335185
36meiotic cell cycle (GO:0051321)4.46992533
37calcium ion-dependent exocytosis (GO:0017156)4.34031783
38organic cation transport (GO:0015695)4.29141912
39regulation of microtubule-based movement (GO:0060632)4.25628341
40genitalia morphogenesis (GO:0035112)4.20948847
41establishment of protein localization to Golgi (GO:0072600)4.09123677
42gene silencing by RNA (GO:0031047)4.08643093
43intraciliary transport (GO:0042073)4.05131391
44multicellular organismal reproductive process (GO:0048609)3.97135965
45regulation of inclusion body assembly (GO:0090083)3.94741315
46lactate metabolic process (GO:0006089)3.90588296
47protein polyglutamylation (GO:0018095)3.85183031
48negative regulation of organelle assembly (GO:1902116)3.76943388
49synapsis (GO:0007129)3.75569117
50protein targeting to Golgi (GO:0000042)3.69299996
51phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.68573832
52regulation of centriole replication (GO:0046599)3.65071466
53left/right pattern formation (GO:0060972)3.63341613
54regulation of protein polyubiquitination (GO:1902914)3.58978571
55microtubule-based movement (GO:0007018)3.56859968
56chaperone-mediated protein complex assembly (GO:0051131)3.56558703
57protein localization to Golgi apparatus (GO:0034067)3.55278644
58interkinetic nuclear migration (GO:0022027)3.49460482
59positive regulation of developmental pigmentation (GO:0048087)3.47934962
60retrograde transport, vesicle recycling within Golgi (GO:0000301)3.44490984
61indolalkylamine metabolic process (GO:0006586)3.40277586
62alditol metabolic process (GO:0019400)3.39568045
63axoneme assembly (GO:0035082)3.39399436
64meiotic cell cycle process (GO:1903046)3.38938518
65preassembly of GPI anchor in ER membrane (GO:0016254)3.36137595
66GTP biosynthetic process (GO:0006183)3.33025472
67negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.32769042
68spermatid nucleus differentiation (GO:0007289)3.31584607
69multicellular organismal development (GO:0007275)3.25488601
70regulation of pigment cell differentiation (GO:0050932)3.24271197
71negative regulation of DNA repair (GO:0045738)3.21217880
72carnitine transmembrane transport (GO:1902603)3.19973562
73glycerol ether metabolic process (GO:0006662)3.19750304
74nucleoside diphosphate phosphorylation (GO:0006165)3.19718875
75polyol catabolic process (GO:0046174)3.17238643
76mannosylation (GO:0097502)3.17020875
77carnitine transport (GO:0015879)3.15314530
78amino-acid betaine transport (GO:0015838)3.15314530
79protein K11-linked deubiquitination (GO:0035871)3.14888391
80detection of light stimulus involved in visual perception (GO:0050908)3.14048704
81detection of light stimulus involved in sensory perception (GO:0050962)3.14048704
82glycerol metabolic process (GO:0006071)3.12612900
83aggressive behavior (GO:0002118)3.12390572
84adenosine metabolic process (GO:0046085)3.12199696
85activated T cell proliferation (GO:0050798)3.12073187
86cilium organization (GO:0044782)3.11071252
87indole-containing compound catabolic process (GO:0042436)3.10337204
88indolalkylamine catabolic process (GO:0046218)3.10337204
89tryptophan catabolic process (GO:0006569)3.10337204
90nuclear pore complex assembly (GO:0051292)3.08373873
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.08183082
92cellular component assembly involved in morphogenesis (GO:0010927)3.03803046
93cilium morphogenesis (GO:0060271)3.02449605
94positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.01350062
95negative regulation of mast cell activation (GO:0033004)2.99839035
96UTP biosynthetic process (GO:0006228)2.97758685
97cilium assembly (GO:0042384)2.94668157
98ether metabolic process (GO:0018904)2.94526263
99centriole replication (GO:0007099)2.93324843
100histone H3-K9 methylation (GO:0051567)2.92562644
101regulation of protein glycosylation (GO:0060049)2.91573922
102regulation of B cell receptor signaling pathway (GO:0050855)2.89789819
103positive regulation of granulocyte differentiation (GO:0030854)2.87105218
104response to pheromone (GO:0019236)2.86633670
105regulation of meiosis I (GO:0060631)2.86371039
106centriole assembly (GO:0098534)2.83203735
107DNA integration (GO:0015074)2.83065822
108regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.82625740
109photoreceptor cell maintenance (GO:0045494)2.81861735
110regulation of spindle checkpoint (GO:0090231)2.81766490
111positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.80100341
112platelet dense granule organization (GO:0060155)2.78182757
113tryptophan metabolic process (GO:0006568)2.77119748
114microtubule anchoring (GO:0034453)2.74730050
115sequestering of actin monomers (GO:0042989)2.73607465
116mitotic sister chromatid cohesion (GO:0007064)2.73344781
117UTP metabolic process (GO:0046051)2.70932271
118NAD biosynthetic process (GO:0009435)2.70646419
119regulation of non-canonical Wnt signaling pathway (GO:2000050)2.70413107
120replication fork processing (GO:0031297)2.70302020
121regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.69293822
122interferon-gamma production (GO:0032609)2.67217617
123regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.66989155
124behavioral response to ethanol (GO:0048149)2.66080776
125valine metabolic process (GO:0006573)2.62926871
126protein complex biogenesis (GO:0070271)2.61740470
127gene silencing (GO:0016458)2.60994443
128regulation of interleukin-6 biosynthetic process (GO:0045408)2.60647013
129neural tube formation (GO:0001841)2.59281139
130protein targeting to vacuole (GO:0006623)2.58460189
131protein targeting to lysosome (GO:0006622)2.58460189
132establishment of protein localization to vacuole (GO:0072666)2.58460189
133regulation of chromatin binding (GO:0035561)2.57996361
134protein K63-linked deubiquitination (GO:0070536)2.56497158
135signal peptide processing (GO:0006465)2.56068667
136peptidyl-glutamic acid modification (GO:0018200)2.55477154
137glycolytic process (GO:0006096)2.55042542
138pyrimidine dimer repair (GO:0006290)2.54320131
139microtubule polymerization or depolymerization (GO:0031109)2.53594493
140regulation of podosome assembly (GO:0071801)2.51808294
141regulation of skeletal muscle contraction (GO:0014819)2.50129645
142NADH dehydrogenase complex assembly (GO:0010257)2.49035917
143mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49035917
144mitochondrial respiratory chain complex I assembly (GO:0032981)2.49035917
145negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.48382608
146DNA methylation (GO:0006306)2.47445499
147DNA alkylation (GO:0006305)2.47445499
148regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.46566352
149prenylation (GO:0097354)2.46420056
150protein prenylation (GO:0018342)2.46420056
151leukotriene biosynthetic process (GO:0019370)2.45449331
152positive regulation of protein homodimerization activity (GO:0090073)2.43074000
153double-strand break repair via homologous recombination (GO:0000724)2.42675536
154recombinational repair (GO:0000725)2.41687016
155behavioral response to nicotine (GO:0035095)2.40727590
156reflex (GO:0060004)2.40609228
157tachykinin receptor signaling pathway (GO:0007217)2.39864841
158kynurenine metabolic process (GO:0070189)2.39634218
159histone H3-K9 modification (GO:0061647)2.39563469
160dopamine transport (GO:0015872)2.38753346
161DNA double-strand break processing (GO:0000729)2.37384018
162purine-containing compound salvage (GO:0043101)2.36659941
163positive regulation of defense response to virus by host (GO:0002230)2.36489995
164amine catabolic process (GO:0009310)2.36095371
165cellular biogenic amine catabolic process (GO:0042402)2.36095371
166regulation of heat generation (GO:0031650)2.35832942
167RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.35644458
168C-terminal protein lipidation (GO:0006501)2.32468509
169L-fucose catabolic process (GO:0042355)2.31404910
170fucose catabolic process (GO:0019317)2.31404910
171L-fucose metabolic process (GO:0042354)2.31404910
172cilium or flagellum-dependent cell motility (GO:0001539)16.4225841
173fusion of sperm to egg plasma membrane (GO:0007342)14.5353904
174acrosome assembly (GO:0001675)13.4169217
175multicellular organism reproduction (GO:0032504)12.1664955
176sperm-egg recognition (GO:0035036)11.4953247
177sperm motility (GO:0030317)11.3611700
178plasma membrane fusion (GO:0045026)11.0804913
179piRNA metabolic process (GO:0034587)10.8570227
180axonemal dynein complex assembly (GO:0070286)10.8234244
181binding of sperm to zona pellucida (GO:0007339)10.4706948
182cell-cell recognition (GO:0009988)10.2988351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.10086158
2EZH2_22144423_ChIP-Seq_EOC_Human5.44907261
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.04997261
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.74175936
5GBX2_23144817_ChIP-Seq_PC3_Human3.59044961
6POU3F2_20337985_ChIP-ChIP_501MEL_Human3.04229533
7* FLI1_27457419_Chip-Seq_LIVER_Mouse2.55509293
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52331934
9IGF1R_20145208_ChIP-Seq_DFB_Human2.49701027
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47543125
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.46902046
12ZNF274_21170338_ChIP-Seq_K562_Hela2.39380066
13* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.28670642
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26766974
15FUS_26573619_Chip-Seq_HEK293_Human2.18582010
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04050274
17P300_19829295_ChIP-Seq_ESCs_Human2.03519275
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.03433849
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02155429
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01771773
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.0965048
22EWS_26573619_Chip-Seq_HEK293_Human1.98650912
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97862229
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.96592776
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94239111
26RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.91491112
27CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.82641566
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82275456
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.81379553
30* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.78852543
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.76586295
32KAP1_22055183_ChIP-Seq_ESCs_Mouse1.75302526
33SMAD4_21799915_ChIP-Seq_A2780_Human1.74532636
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70008151
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69932270
36* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68134237
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.67679294
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66482363
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63639799
40STAT3_23295773_ChIP-Seq_U87_Human1.62655631
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.60483732
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57111576
43GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.56777464
44* NFE2_27457419_Chip-Seq_LIVER_Mouse1.54990408
45STAT1_17558387_ChIP-Seq_HELA_Human1.53871298
46RNF2_27304074_Chip-Seq_NSC_Mouse1.51931810
47* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51505236
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.51332603
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50947709
50TAL1_26923725_Chip-Seq_HPCs_Mouse1.48631938
51AR_25329375_ChIP-Seq_VCAP_Human1.47497345
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46055932
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44810017
54VDR_22108803_ChIP-Seq_LS180_Human1.43879211
55KDM2B_26808549_Chip-Seq_REH_Human1.43870709
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40546688
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.39324822
58AR_21572438_ChIP-Seq_LNCaP_Human1.37060918
59* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36716558
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36281883
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36115900
62CBP_20019798_ChIP-Seq_JUKART_Human1.36115900
63FLI1_21867929_ChIP-Seq_TH2_Mouse1.35667555
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32596277
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30837782
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.30544412
67NANOG_19829295_ChIP-Seq_ESCs_Human1.29780843
68SOX2_19829295_ChIP-Seq_ESCs_Human1.29780843
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28976763
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.28930142
71* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28599698
72TCF4_22108803_ChIP-Seq_LS180_Human1.27626249
73* NANOG_18555785_Chip-Seq_ESCs_Mouse1.27329435
74FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27188587
75* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27177833
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25554815
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24449257
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24449257
79* CRX_20693478_ChIP-Seq_RETINA_Mouse1.24168139
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23643372
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22573866
82TP53_22573176_ChIP-Seq_HFKS_Human1.22403532
83* OCT4_18555785_Chip-Seq_ESCs_Mouse1.20766604
84CDX2_22108803_ChIP-Seq_LS180_Human1.19763155
85GATA3_21867929_ChIP-Seq_CD8_Mouse1.18851952
86* EZH2_27294783_Chip-Seq_NPCs_Mouse1.18460655
87GATA3_21867929_ChIP-Seq_TH1_Mouse1.18076350
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17418440
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17245110
90TP53_16413492_ChIP-PET_HCT116_Human1.15947421
91LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.14265753
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13822437
93* P53_22387025_ChIP-Seq_ESCs_Mouse1.13627762
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13482351
95* P300_18555785_Chip-Seq_ESCs_Mouse1.13090588
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13056327
97* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12567592
98SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12409918
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12020765
100SOX2_22085726_ChIP-Seq_NPCs_Mouse1.11355026
101* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10920095
102RUNX2_22187159_ChIP-Seq_PCA_Human1.09932088
103* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07986122
104* KLF4_18555785_Chip-Seq_ESCs_Mouse1.07521830
105* REST_21632747_ChIP-Seq_MESCs_Mouse1.05751825
106* CMYC_18555785_Chip-Seq_ESCs_Mouse1.05438903
107* STAT3_18555785_Chip-Seq_ESCs_Mouse1.05253652
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05094205
109CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05058418
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04946361
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04946361
112* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04226934
113* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03977914
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03712280
115* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03530924
116IRF1_19129219_ChIP-ChIP_H3396_Human1.03288261
117GF1_26923725_Chip-Seq_HPCs_Mouse1.03193032
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.02550676
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00911158
120RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00363668
121* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99287458
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.97979064
123BCAT_22108803_ChIP-Seq_LS180_Human0.96492382
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95197341
125TAF15_26573619_Chip-Seq_HEK293_Human0.95162168
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94206610
127P53_21459846_ChIP-Seq_SAOS-2_Human0.94162180
128ER_23166858_ChIP-Seq_MCF-7_Human0.92951059
129SALL1_21062744_ChIP-ChIP_HESCs_Human0.92496105
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92390138
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92018403
132* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91917697
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90165405
134* E2F1_18555785_Chip-Seq_ESCs_Mouse0.89869557
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88901300
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88898992
137ESET_19884257_ChIP-Seq_ESCs_Mouse0.88834315
138* SOX2_18555785_Chip-Seq_ESCs_Mouse0.88772292
139* TCF4_23295773_ChIP-Seq_U87_Human0.88659663
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88555073
141* CTCF_18555785_Chip-Seq_ESCs_Mouse0.88451831
142* ZFX_18555785_Chip-Seq_ESCs_Mouse0.87697114
143* PU1_27457419_Chip-Seq_LIVER_Mouse0.87163086
144GF1B_26923725_Chip-Seq_HPCs_Mouse0.87089128
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86346290
146SOX9_26525672_Chip-Seq_HEART_Mouse0.85763313
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84002983
148FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83740787
149FOXA1_25329375_ChIP-Seq_VCAP_Human0.83740787
150SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83563405
151ERG_20517297_ChIP-Seq_VCAP_Human0.82979028
152* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.82831491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.92621731
2MP0008877_abnormal_DNA_methylation5.74049324
3MP0001929_abnormal_gametogenesis5.55021488
4MP0002210_abnormal_sex_determination3.93061537
5MP0002653_abnormal_ependyma_morphology3.85156554
6MP0001145_abnormal_male_reproductive3.31693449
7MP0002161_abnormal_fertility/fecundity3.17638865
8MP0002837_dystrophic_cardiac_calcinosis3.03852175
9MP0005075_abnormal_melanosome_morpholog2.96627952
10MP0000372_irregular_coat_pigmentation2.92008900
11MP0000653_abnormal_sex_gland2.90038964
12MP0005623_abnormal_meninges_morphology2.87420935
13MP0008057_abnormal_DNA_replication2.85618824
14MP0003195_calcinosis2.32922555
15MP0005645_abnormal_hypothalamus_physiol2.25156514
16MP0002736_abnormal_nociception_after2.10406666
17MP0005410_abnormal_fertilization14.7430175
18MP0001835_abnormal_antigen_presentation1.90192770
19MP0002160_abnormal_reproductive_system1.85087684
20MP0002638_abnormal_pupillary_reflex1.80612436
21MP0001968_abnormal_touch/_nociception1.78723094
22MP0009046_muscle_twitch1.77277964
23MP0005646_abnormal_pituitary_gland1.75083502
24MP0001986_abnormal_taste_sensitivity1.72141850
25MP0003763_abnormal_thymus_physiology1.71442768
26MP0008058_abnormal_DNA_repair1.67420033
27MP0002876_abnormal_thyroid_physiology1.57093515
28MP0002282_abnormal_trachea_morphology1.53282400
29MP0004484_altered_response_of1.52463741
30MP0005647_abnormal_sex_gland1.50318153
31MP0008775_abnormal_heart_ventricle1.46467863
32MP0010094_abnormal_chromosome_stability1.41730249
33MP0003183_abnormal_peptide_metabolism1.36518238
34MP0004215_abnormal_myocardial_fiber1.36497386
35MP0001501_abnormal_sleep_pattern1.33143988
36MP0008872_abnormal_physiological_respon1.32946470
37MP0000465_gastrointestinal_hemorrhage1.29968649
38MP0006292_abnormal_olfactory_placode1.29488889
39MP0002095_abnormal_skin_pigmentation1.29217433
40MP0008007_abnormal_cellular_replicative1.28146651
41MP0005174_abnormal_tail_pigmentation1.23129445
42MP0001486_abnormal_startle_reflex1.20282728
43MP0005671_abnormal_response_to1.19414736
44MP0003787_abnormal_imprinting1.15518914
45MP0005085_abnormal_gallbladder_physiolo1.15247300
46MP0003646_muscle_fatigue1.11847521
47MP0005084_abnormal_gallbladder_morpholo1.11458538
48MP0003786_premature_aging1.11102900
49MP0003011_delayed_dark_adaptation1.10736065
50MP0001800_abnormal_humoral_immune1.04936622
51MP0005310_abnormal_salivary_gland1.04287744
52MP0004147_increased_porphyrin_level1.03873117
53MP0003943_abnormal_hepatobiliary_system1.03798741
54MP0002138_abnormal_hepatobiliary_system1.02765742
55MP0000230_abnormal_systemic_arterial1.02652632
56MP0005670_abnormal_white_adipose1.02557580
57MP0002332_abnormal_exercise_endurance1.02240200
58MP0002272_abnormal_nervous_system1.01659100
59MP0008995_early_reproductive_senescence1.01429150
60MP0000013_abnormal_adipose_tissue1.00887181
61MP0003252_abnormal_bile_duct1.00229515
62MP0004142_abnormal_muscle_tone0.99985442
63MP0000383_abnormal_hair_follicle0.99866628
64MP0005387_immune_system_phenotype0.99621018
65MP0001790_abnormal_immune_system0.99621018
66MP0005389_reproductive_system_phenotype0.98422477
67MP0005367_renal/urinary_system_phenotyp0.98250562
68MP0000516_abnormal_urinary_system0.98250562
69MP0000631_abnormal_neuroendocrine_gland0.96740026
70MP0001765_abnormal_ion_homeostasis0.95339975
71MP0001984_abnormal_olfaction0.94662152
72MP0002735_abnormal_chemical_nociception0.94587677
73MP0009745_abnormal_behavioral_response0.91462726
74MP0002938_white_spotting0.91360822
75MP0004134_abnormal_chest_morphology0.91095340
76MP0003950_abnormal_plasma_membrane0.90342649
77MP0000015_abnormal_ear_pigmentation0.89124522
78MP0003866_abnormal_defecation0.89051004
79MP0005171_absent_coat_pigmentation0.85195488
80MP0002148_abnormal_hypersensitivity_rea0.81400341
81MP0004381_abnormal_hair_follicle0.80400834
82MP0000569_abnormal_digit_pigmentation0.79683591
83MP0002168_other_aberrant_phenotype0.78113126
84MP0005379_endocrine/exocrine_gland_phen0.77209853
85MP0002166_altered_tumor_susceptibility0.76030095
86MP0003724_increased_susceptibility_to0.75803329
87MP0009697_abnormal_copulation0.75456923
88MP0002090_abnormal_vision0.75234553
89MP0010307_abnormal_tumor_latency0.73751514
90MP0004233_abnormal_muscle_weight0.72613965
91MP0002067_abnormal_sensory_capabilities0.72426077
92MP0002723_abnormal_immune_serum0.71222776
93MP0000689_abnormal_spleen_morphology0.70384833
94MP0004808_abnormal_hematopoietic_stem0.69757568
95MP0006276_abnormal_autonomic_nervous0.69377005
96MP0001756_abnormal_urination0.68221287
97MP0010386_abnormal_urinary_bladder0.67903747
98MP0006054_spinal_hemorrhage0.67124540
99MP0005397_hematopoietic_system_phenotyp0.65648684
100MP0001545_abnormal_hematopoietic_system0.65648684
101MP0000358_abnormal_cell_content/0.61503371
102MP0000427_abnormal_hair_cycle0.61385065
103MP0003699_abnormal_female_reproductive0.54357189
104MP0004019_abnormal_vitamin_homeostasis0.53457299
105MP0001119_abnormal_female_reproductive0.51070193
106MP0002928_abnormal_bile_duct0.49993458
107MP0004036_abnormal_muscle_relaxation0.49083121
108MP0003111_abnormal_nucleus_morphology0.46074449
109MP0001730_embryonic_growth_arrest0.45954686
110MP0005636_abnormal_mineral_homeostasis0.44601991
111MP0005551_abnormal_eye_electrophysiolog0.44470471
112MP0005253_abnormal_eye_physiology0.44392257
113MP0002234_abnormal_pharynx_morphology0.38695847
114MP0003077_abnormal_cell_cycle0.38593531
115MP0002139_abnormal_hepatobiliary_system0.38159226
116MP0003329_amyloid_beta_deposits0.37298253
117MP0009278_abnormal_bone_marrow0.35793186
118MP0006072_abnormal_retinal_apoptosis0.35403749
119MP0006138_congestive_heart_failure0.35338447
120MP0001293_anophthalmia0.34788889
121MP0003633_abnormal_nervous_system0.34775464
122MP0005391_vision/eye_phenotype0.34406802
123MP0000647_abnormal_sebaceous_gland0.33812448
124MP0001324_abnormal_eye_pigmentation0.33686110
125MP0005377_hearing/vestibular/ear_phenot0.33221278
126MP0003878_abnormal_ear_physiology0.33221278
127MP0000313_abnormal_cell_death0.32390517
128MP0001727_abnormal_embryo_implantation0.31563480
129MP0003631_nervous_system_phenotype0.27213704
130MP0004084_abnormal_cardiac_muscle0.26686705
131MP0001851_eye_inflammation0.26682563
132MP0003861_abnormal_nervous_system0.25425462
133MP0002152_abnormal_brain_morphology0.24627723
134MP0002971_abnormal_brown_adipose0.24488681
135MP0004133_heterotaxia0.23645148
136MP0003115_abnormal_respiratory_system0.23119265
137MP0002084_abnormal_developmental_patter0.22867311
138MP0006036_abnormal_mitochondrial_physio0.22327208
139MP0002102_abnormal_ear_morphology0.21544431
140MP0000432_abnormal_head_morphology0.21528684
141MP0004811_abnormal_neuron_physiology0.20997669
142MP0005666_abnormal_adipose_tissue0.19920000
143MP0005076_abnormal_cell_differentiation0.19302391
144MP0002269_muscular_atrophy0.19159039
145MP0000604_amyloidosis0.18251028
146MP0002092_abnormal_eye_morphology0.17625370
147MP0005388_respiratory_system_phenotype0.16536434
148MP0002133_abnormal_respiratory_system0.16536434
149MP0008875_abnormal_xenobiotic_pharmacok0.15982531
150MP0001764_abnormal_homeostasis0.15668189
151MP0002229_neurodegeneration0.15637545
152MP0005380_embryogenesis_phenotype0.15403745
153MP0001672_abnormal_embryogenesis/_devel0.15403745
154MP0003045_fibrosis0.15262192
155MP0005365_abnormal_bile_salt0.15221130
156MP0005266_abnormal_metabolism0.14528395
157MP0001697_abnormal_embryo_size0.14502504
158MP0004043_abnormal_pH_regulation0.14389922
159MP0009115_abnormal_fat_cell0.14152973
160MP0000778_abnormal_nervous_system0.14006221
161MP0002405_respiratory_system_inflammati0.13421051
162MP0005195_abnormal_posterior_eye0.13283393
163MP0003984_embryonic_growth_retardation0.12877854
164MP0001919_abnormal_reproductive_system0.11163452
165MP0002169_no_abnormal_phenotype0.11115667
166MP0002873_normal_phenotype0.10982715

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.82299961
2Abnormal respiratory motile cilium morphology (HP:0005938)8.82299961
3Abnormal ciliary motility (HP:0012262)8.53243882
4Rhinitis (HP:0012384)8.17049548
5Chronic bronchitis (HP:0004469)7.62627216
6Nasal polyposis (HP:0100582)6.39744772
7Infertility (HP:0000789)5.94212280
8Abnormality of the nasal mucosa (HP:0000433)5.26137941
9Bronchiectasis (HP:0002110)4.62235446
10Bronchitis (HP:0012387)4.55026484
11Nephronophthisis (HP:0000090)4.22586709
12Recurrent sinusitis (HP:0011108)3.99466080
13Hyperventilation (HP:0002883)3.85564064
14Pancreatic cysts (HP:0001737)3.65908246
15Abnormality of the lower motor neuron (HP:0002366)3.64216534
16Renal cortical cysts (HP:0000803)3.46709713
17Recurrent otitis media (HP:0000403)3.36220214
18Autoimmune hemolytic anemia (HP:0001890)3.36146110
19Abnormality of the renal medulla (HP:0100957)3.24507222
20Chronic hepatic failure (HP:0100626)3.13186841
21Absent speech (HP:0001344)2.89734703
22Focal motor seizures (HP:0011153)2.89532709
23Fibular hypoplasia (HP:0003038)2.89071686
24Male infertility (HP:0003251)2.87702984
25Bile duct proliferation (HP:0001408)2.84522984
26Abnormal biliary tract physiology (HP:0012439)2.84522984
27Attenuation of retinal blood vessels (HP:0007843)2.83220956
28Amyotrophic lateral sclerosis (HP:0007354)2.82213593
29Visual hallucinations (HP:0002367)2.78774003
30Febrile seizures (HP:0002373)2.78588111
31Gonadotropin excess (HP:0000837)2.78164253
32Abnormal spermatogenesis (HP:0008669)2.68832660
33Tubulointerstitial nephritis (HP:0001970)2.68100544
34Abnormality of midbrain morphology (HP:0002418)2.61159355
35Molar tooth sign on MRI (HP:0002419)2.61159355
36Dyschromatopsia (HP:0007641)2.61145252
37Broad-based gait (HP:0002136)2.56703705
38Autoimmune thrombocytopenia (HP:0001973)2.55669093
39Medial flaring of the eyebrow (HP:0010747)2.53952634
40Progressive inability to walk (HP:0002505)2.52617785
41Recurrent bronchitis (HP:0002837)2.49959329
42Type II lissencephaly (HP:0007260)2.39364181
43Fair hair (HP:0002286)2.33693380
44Hypothermia (HP:0002045)2.33464522
45Absent frontal sinuses (HP:0002688)2.33053954
46Congenital stationary night blindness (HP:0007642)2.32385470
47Abnormality of B cell number (HP:0010975)2.29783024
48Abnormal rod and cone electroretinograms (HP:0008323)2.27945477
49Tubulointerstitial abnormality (HP:0001969)2.26139120
50Tubular atrophy (HP:0000092)2.25993989
51Microglossia (HP:0000171)2.25521740
52Enlarged kidneys (HP:0000105)2.23671136
53Inability to walk (HP:0002540)2.21575077
54Abolished electroretinogram (ERG) (HP:0000550)2.20239096
55Bulbous nose (HP:0000414)2.19972810
56Stomach cancer (HP:0012126)2.18952059
57J-shaped sella turcica (HP:0002680)2.18221294
58Type I transferrin isoform profile (HP:0003642)2.17164637
59Congenital sensorineural hearing impairment (HP:0008527)2.15917760
60Upper motor neuron abnormality (HP:0002127)2.15111477
61Thyroiditis (HP:0100646)2.15036060
62Azoospermia (HP:0000027)2.14920506
63Long nose (HP:0003189)2.14370026
64Postaxial foot polydactyly (HP:0001830)2.14289208
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.14181697
66Stomatitis (HP:0010280)2.11172226
67Dialeptic seizures (HP:0011146)2.10125708
68Hypoplastic ischia (HP:0003175)2.08404709
69Impaired proprioception (HP:0010831)2.08033944
7011 pairs of ribs (HP:0000878)2.07395862
71Abnormality of macular pigmentation (HP:0008002)2.06322103
72Central scotoma (HP:0000603)2.05225442
73Abnormality of the prostate (HP:0008775)2.04475128
74Focal seizures (HP:0007359)2.03508958
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02675437
76Abnormal protein N-linked glycosylation (HP:0012347)2.02675437
77Abnormal protein glycosylation (HP:0012346)2.02675437
78Abnormal glycosylation (HP:0012345)2.02675437
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.4210921
80Dynein arm defect of respiratory motile cilia (HP:0012255)12.8085283
81Absent/shortened dynein arms (HP:0200106)12.8085283
82Abnormal respiratory motile cilium physiology (HP:0012261)10.0296045
83Genital tract atresia (HP:0001827)1.99451007
84Progressive cerebellar ataxia (HP:0002073)1.98848372
85Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97571324
86Hyperkalemia (HP:0002153)1.96979365
87Abnormality of the ischium (HP:0003174)1.94723224
88Prostate neoplasm (HP:0100787)1.93991058
89Widely spaced teeth (HP:0000687)1.90735717
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90658719
91Decreased central vision (HP:0007663)1.90490038
92Atonic seizures (HP:0010819)1.90297972
93Abnormality of the anterior horn cell (HP:0006802)1.90292164
94Degeneration of anterior horn cells (HP:0002398)1.90292164
95Congenital hepatic fibrosis (HP:0002612)1.89012496
96Panhypogammaglobulinemia (HP:0003139)1.87894756
97Cerebellar dysplasia (HP:0007033)1.87367538
98Stage 5 chronic kidney disease (HP:0003774)1.86389854
99Abnormality of the dental root (HP:0006486)1.85460062
100Taurodontia (HP:0000679)1.85460062
101Abnormality of permanent molar morphology (HP:0011071)1.85460062
102Aplasia/Hypoplasia of the fibula (HP:0006492)1.85117442
103Genetic anticipation (HP:0003743)1.83034916
104Vaginal atresia (HP:0000148)1.82325980
105Abnormality of the renal cortex (HP:0011035)1.82004374
106Aplasia/Hypoplasia of the tibia (HP:0005772)1.80671827
107Tented upper lip vermilion (HP:0010804)1.80237173
108Abnormal delayed hypersensitivity skin test (HP:0002963)1.80172293
109Cupped ear (HP:0000378)1.80148660
110B lymphocytopenia (HP:0010976)1.79832016
111Tubulointerstitial fibrosis (HP:0005576)1.79129574
112Reduced antithrombin III activity (HP:0001976)1.79013556
113Short ribs (HP:0000773)1.78669450
114Acute hepatic failure (HP:0006554)1.78188323
115Chronic sinusitis (HP:0011109)1.77809463
116Abnormality of molar morphology (HP:0011070)1.74059775
117Abnormality of molar (HP:0011077)1.74059775
118Facial diplegia (HP:0001349)1.72906795
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.72884505
120Polyuria (HP:0000103)1.71338001
121Breast carcinoma (HP:0003002)1.70790999
122Facial cleft (HP:0002006)1.70764354
123Pancreatic fibrosis (HP:0100732)1.69828689
124Renal dysplasia (HP:0000110)1.68877991
125Supernumerary spleens (HP:0009799)1.68781096
126Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68778767
127Impulsivity (HP:0100710)1.68723128
128Oculomotor apraxia (HP:0000657)1.68463497
129Abnormality of dentin (HP:0010299)1.68142775
130Abnormality of the dental pulp (HP:0006479)1.67626413
131Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66964187
132Absence seizures (HP:0002121)1.66855809
133Selective tooth agenesis (HP:0001592)1.66790321
134Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66669219
135Abnormality of T cell physiology (HP:0011840)1.65844269
136Abnormality of T cell number (HP:0011839)1.65542011
137Large eyes (HP:0001090)1.59216807
138Median cleft lip (HP:0000161)1.58927088
139Polydipsia (HP:0001959)1.58295714
140Abnormal drinking behavior (HP:0030082)1.58295714
141Postaxial hand polydactyly (HP:0001162)1.57175547
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.55395274
143Absent epiphyses (HP:0010577)1.55395274
144Cystic liver disease (HP:0006706)1.50740312
145Gait imbalance (HP:0002141)1.50304078
146Congenital primary aphakia (HP:0007707)1.49626630
147Abnormality of renal excretion (HP:0011036)1.48138682
148Deformed sella turcica (HP:0002681)1.44564868
149Conjunctival telangiectasia (HP:0000524)1.39974819
150Spastic tetraparesis (HP:0001285)1.36703463
151Short thorax (HP:0010306)1.36525268
152Hypoplasia of dental enamel (HP:0006297)1.33960250
153Vascular calcification (HP:0004934)1.31829952
154Abnormality of ocular smooth pursuit (HP:0000617)1.28137835
155Nephroblastoma (Wilms tumor) (HP:0002667)1.27975194
156True hermaphroditism (HP:0010459)1.27485167
157Nephrogenic diabetes insipidus (HP:0009806)1.26448217
158Abnormality of the frontal sinuses (HP:0002687)1.25525744
159Pachygyria (HP:0001302)1.25335871
160Nephropathy (HP:0000112)1.23469340
161Broad distal phalanx of finger (HP:0009836)1.23370379
162Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.21843426
163Gaze-evoked nystagmus (HP:0000640)1.20138136
164Cardiovascular calcification (HP:0011915)1.18552953
165Heterotopia (HP:0002282)1.18550738
166Embryonal renal neoplasm (HP:0011794)1.18150074
167Bell-shaped thorax (HP:0001591)1.17601335
168Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.16593584
169Decreased motor nerve conduction velocity (HP:0003431)1.16537221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.60221041
2PDK39.60221041
3PDK26.23740907
4FRK5.69331310
5TAOK33.45474288
6TESK13.00210920
7WNK42.75733741
8STK392.73800618
9PTK2B2.52206706
10PRKD32.48873218
11PNCK2.43023490
12TXK2.42945380
13NUAK12.33257925
14MAP4K22.07564826
15TEC1.98114529
16NLK1.97675136
17ICK1.97568176
18LATS11.97354225
19BCR1.93717069
20INSRR1.90674804
21AKT31.87135615
22NEK21.80329670
23ADRBK21.78421244
24BMPR21.78030382
25PIK3CG1.76294394
26ZAK1.61763228
27ERBB31.58964978
28MST41.52793299
29EIF2AK31.51300543
30MAPK131.46166169
31OBSCN1.32771276
32TNK21.27968225
33TGFBR21.24986050
34WNK11.22940901
35GRK11.18257958
36TRIM281.13532988
37SGK21.13116601
38IKBKE1.12753151
39STK381.10564245
40TRPM71.09052611
41CCNB11.04840259
42FER1.02508959
43STK31.02373766
44WEE11.01093084
45IKBKB1.00534489
46CDC70.99661179
47MAP3K120.99648292
48CASK0.99585820
49TYRO30.98902409
50MAPK150.95353300
51TLK10.93838238
52BTK0.92622099
53PASK0.92427748
54KIT0.92178026
55PDK10.90094089
56ADRBK10.85023882
57SYK0.84906013
58VRK10.83349075
59ITK0.83116399
60FLT30.80462246
61CAMKK20.79573658
62TGFBR10.78839086
63TTK0.76966730
64PIK3CA0.75487480
65PRKCE0.72760182
66HCK0.71439843
67DYRK30.69747737
68GRK50.68457114
69NTRK30.67700699
70TIE10.65301351
71BMPR1B0.65097508
72LCK0.64530715
73LMTK20.63421117
74FES0.61954517
75ATR0.59941493
76FGFR20.59252221
77CHEK10.57044904
78TNIK0.57035991
79MAP3K60.56644929
80LYN0.56581529
81STK160.55581729
82STK38L0.55405017
83DAPK20.55076389
84PINK10.53446088
85IRAK10.53246027
86EPHA30.53233835
87CLK10.52619185
88CHEK20.52462974
89CSNK1G10.52170158
90SGK30.51733748
91DYRK1B0.51122000
92BRSK20.48969881
93PAK30.48496421
94GRK60.48001580
95JAK10.45931202
96MYLK0.44459427
97ABL10.43331494
98DYRK1A0.43233035
99SGK4940.43021375
100SGK2230.43021375
101GRK70.42332326
102TESK20.40699190
103MELK0.40155188
104ATM0.40074958
105CAMK2D0.38441880
106CAMK1G0.38106300
107MAP3K50.37966994
108BLK0.36235243
109MAP2K70.35811672
110JAK30.35445931
111PLK40.34892689
112PLK10.34699120
113PLK20.34553287
114MAP3K40.34374966
115PHKG20.34159466
116PDPK10.26396875
117CAMKK10.25879693
118MAP2K60.25582099
119NTRK20.22486178
120MAPKAPK50.20949982
121PAK10.20535624
122NEK60.20298863
123RPS6KB10.20053989
124CDK120.19172811
125MTOR0.18652471
126PRKCG0.18600093
127PRKAA10.18109989
128BRSK10.15753632
129MARK30.15654149
130MUSK0.14920386
131BRAF0.13917045
132PAK20.12056340
133EEF2K0.11928548
134PRKG10.11427122
135PDGFRB0.11171747
136ZAP700.10928132
137PRKACG0.10259006
138CSNK1D0.10203161
139CDK10.10019502
140STK100.08907414
141CDK30.06942672
142CDK150.06942227
143PRKDC0.06936478
144PRKCQ0.06603950
145MAPK80.06551525
146CSNK2A10.06278584
147CDK20.05803325
148MARK20.05738562
149PRKACB0.05605832
150WNK30.05474221
151PAK60.05112104
152IRAK20.04882490
153CDK180.04542158
154RIPK40.03882843
155CDK11A0.03566196
156CSNK2A20.02924891
157MAPK100.02865178
158GSK3B0.02703152
159ACVR1B0.02157006
160CDK140.01782883
161CSF1R0.01247377
162STK110.00864504
163OXSR10.00731688
164PKN10.00725681
165EGFR0.00534555
166MAP2K4-0.0323102
167MINK1-0.0299558
168MAPK1-0.0250963
169PRKACA-0.0227927
170INSR-0.0205334
171AURKA-0.0184640
172PRKCB-0.0169226
173PRKCZ-0.0105413
174CAMK2A-0.0080882
175RPS6KA3-0.0023643

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.39950268
2Pyruvate metabolism_Homo sapiens_hsa006204.73587017
3Propanoate metabolism_Homo sapiens_hsa006404.07715455
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.91780922
5Pentose phosphate pathway_Homo sapiens_hsa000303.63760991
6Glucagon signaling pathway_Homo sapiens_hsa049223.02375826
7Basal transcription factors_Homo sapiens_hsa030222.91241679
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.82959938
9Fanconi anemia pathway_Homo sapiens_hsa034602.61296948
10Fatty acid biosynthesis_Homo sapiens_hsa000612.45748961
11Selenocompound metabolism_Homo sapiens_hsa004502.35661702
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.29721875
13Dorso-ventral axis formation_Homo sapiens_hsa043202.28501693
14Nitrogen metabolism_Homo sapiens_hsa009102.12704702
15Phototransduction_Homo sapiens_hsa047442.10546368
16Oocyte meiosis_Homo sapiens_hsa041142.09386425
17Glycosaminoglycan degradation_Homo sapiens_hsa005312.07567701
18Huntingtons disease_Homo sapiens_hsa050162.06486514
19Cysteine and methionine metabolism_Homo sapiens_hsa002702.04680105
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.91645488
21Linoleic acid metabolism_Homo sapiens_hsa005911.84409862
22Asthma_Homo sapiens_hsa053101.80359753
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79772413
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78103850
25Glycerolipid metabolism_Homo sapiens_hsa005611.77305395
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.70458048
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.69792292
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68080812
29Amphetamine addiction_Homo sapiens_hsa050311.63869874
30Carbon metabolism_Homo sapiens_hsa012001.56906804
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.56593291
32PPAR signaling pathway_Homo sapiens_hsa033201.55739791
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55584007
34Renin secretion_Homo sapiens_hsa049241.51971548
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51934697
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51592488
37Nicotine addiction_Homo sapiens_hsa050331.51349267
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43471570
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38403000
40Biosynthesis of amino acids_Homo sapiens_hsa012301.36672113
41Allograft rejection_Homo sapiens_hsa053301.35754495
42Graft-versus-host disease_Homo sapiens_hsa053321.35606679
43Butanoate metabolism_Homo sapiens_hsa006501.35582549
44Regulation of autophagy_Homo sapiens_hsa041401.34490290
45Type I diabetes mellitus_Homo sapiens_hsa049401.28342983
46Platelet activation_Homo sapiens_hsa046111.27829837
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26722914
48Tryptophan metabolism_Homo sapiens_hsa003801.26068846
49Autoimmune thyroid disease_Homo sapiens_hsa053201.24818258
50Circadian rhythm_Homo sapiens_hsa047101.24663754
51Primary immunodeficiency_Homo sapiens_hsa053401.24442136
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16796114
53RNA transport_Homo sapiens_hsa030131.14774627
54Morphine addiction_Homo sapiens_hsa050321.14548115
55mRNA surveillance pathway_Homo sapiens_hsa030151.14398147
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11062532
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10849903
58Cardiac muscle contraction_Homo sapiens_hsa042601.10168198
59Peroxisome_Homo sapiens_hsa041461.01647925
60Caffeine metabolism_Homo sapiens_hsa002321.01480471
61Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01051211
62Jak-STAT signaling pathway_Homo sapiens_hsa046301.00011189
63Fructose and mannose metabolism_Homo sapiens_hsa000510.99484234
64Long-term potentiation_Homo sapiens_hsa047200.99387634
65Ovarian steroidogenesis_Homo sapiens_hsa049130.98062870
66Salivary secretion_Homo sapiens_hsa049700.97264104
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.97127018
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96858475
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91995906
70Purine metabolism_Homo sapiens_hsa002300.91808046
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91076207
72Serotonergic synapse_Homo sapiens_hsa047260.90344529
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88253813
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.87846479
75Ether lipid metabolism_Homo sapiens_hsa005650.81795030
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81551135
77RNA polymerase_Homo sapiens_hsa030200.80910470
78ABC transporters_Homo sapiens_hsa020100.79374777
79Long-term depression_Homo sapiens_hsa047300.79117516
80Fatty acid metabolism_Homo sapiens_hsa012120.78981331
81Fat digestion and absorption_Homo sapiens_hsa049750.78723290
82Sphingolipid metabolism_Homo sapiens_hsa006000.77881903
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76728593
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76104573
85GABAergic synapse_Homo sapiens_hsa047270.74414032
86Fatty acid degradation_Homo sapiens_hsa000710.73995758
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72615259
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71102136
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69075909
90Renin-angiotensin system_Homo sapiens_hsa046140.68854677
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66412888
92Antigen processing and presentation_Homo sapiens_hsa046120.64371734
93Calcium signaling pathway_Homo sapiens_hsa040200.60599146
94VEGF signaling pathway_Homo sapiens_hsa043700.59987446
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59915235
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59856084
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58978458
98Mineral absorption_Homo sapiens_hsa049780.58459014
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58178502
100Chemical carcinogenesis_Homo sapiens_hsa052040.58007011
101Homologous recombination_Homo sapiens_hsa034400.56764546
102Non-homologous end-joining_Homo sapiens_hsa034500.56629282
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55737553
104Glutathione metabolism_Homo sapiens_hsa004800.53883569
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50298659
106Collecting duct acid secretion_Homo sapiens_hsa049660.49950636
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.49483057
108Estrogen signaling pathway_Homo sapiens_hsa049150.48910094
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48101211
110Cholinergic synapse_Homo sapiens_hsa047250.45839783
111N-Glycan biosynthesis_Homo sapiens_hsa005100.44928837
112Measles_Homo sapiens_hsa051620.44909499
113Cell cycle_Homo sapiens_hsa041100.44506408
114Hematopoietic cell lineage_Homo sapiens_hsa046400.43743508
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.43527723
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43390353
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41909199
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41788978
119RNA degradation_Homo sapiens_hsa030180.41605373
120Protein export_Homo sapiens_hsa030600.40644186
121AMPK signaling pathway_Homo sapiens_hsa041520.40281416
122Pancreatic secretion_Homo sapiens_hsa049720.39501185
123Type II diabetes mellitus_Homo sapiens_hsa049300.38430424
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37395430
125FoxO signaling pathway_Homo sapiens_hsa040680.37256453
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.36704167
127Metabolic pathways_Homo sapiens_hsa011000.35856012
128B cell receptor signaling pathway_Homo sapiens_hsa046620.35115502
129Inositol phosphate metabolism_Homo sapiens_hsa005620.31924587
130Endocytosis_Homo sapiens_hsa041440.29192448
131Insulin secretion_Homo sapiens_hsa049110.28079629
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.27189520
133Olfactory transduction_Homo sapiens_hsa047400.25739494
134Arachidonic acid metabolism_Homo sapiens_hsa005900.25529106
135Lysine degradation_Homo sapiens_hsa003100.25257147
136Taste transduction_Homo sapiens_hsa047420.24341917
137Retinol metabolism_Homo sapiens_hsa008300.24340199
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24008501
139Glutamatergic synapse_Homo sapiens_hsa047240.23723908
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23446993
141Viral carcinogenesis_Homo sapiens_hsa052030.22350156
142Thyroid hormone synthesis_Homo sapiens_hsa049180.22205797
143Synaptic vesicle cycle_Homo sapiens_hsa047210.22166496
144Circadian entrainment_Homo sapiens_hsa047130.21288093
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19685458
146Systemic lupus erythematosus_Homo sapiens_hsa053220.19377703
147Bile secretion_Homo sapiens_hsa049760.19260669
148Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.18016623
149Wnt signaling pathway_Homo sapiens_hsa043100.17589033
150Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16244689
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.14740442
152Sulfur metabolism_Homo sapiens_hsa009200.13490331
153HTLV-I infection_Homo sapiens_hsa051660.12158848
154cAMP signaling pathway_Homo sapiens_hsa040240.11648505
155T cell receptor signaling pathway_Homo sapiens_hsa046600.11350592
156Salmonella infection_Homo sapiens_hsa051320.09991902
157Oxytocin signaling pathway_Homo sapiens_hsa049210.09983939
158Dopaminergic synapse_Homo sapiens_hsa047280.09951461

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